ZNF418

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)4.40960260
2presynaptic membrane assembly (GO:0097105)4.38416894
3DNA double-strand break processing (GO:0000729)4.26342883
4pyrimidine nucleobase catabolic process (GO:0006208)4.06643975
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.89515982
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.89515982
7regulation of translation, ncRNA-mediated (GO:0045974)3.89515982
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44132231
9replication fork processing (GO:0031297)3.43021008
10postsynaptic membrane organization (GO:0001941)3.32244335
11neural tube formation (GO:0001841)3.18329660
12neuron cell-cell adhesion (GO:0007158)3.16269894
13L-fucose catabolic process (GO:0042355)3.16048736
14fucose catabolic process (GO:0019317)3.16048736
15L-fucose metabolic process (GO:0042354)3.16048736
16resolution of meiotic recombination intermediates (GO:0000712)3.13217727
17DNA integration (GO:0015074)3.12597196
18limb bud formation (GO:0060174)3.03872957
19nucleobase catabolic process (GO:0046113)3.02069874
20centriole replication (GO:0007099)3.00939090
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98524332
22kidney morphogenesis (GO:0060993)2.95713447
23negative regulation of DNA-dependent DNA replication (GO:2000104)2.94922736
24nonmotile primary cilium assembly (GO:0035058)2.89177956
25cilium morphogenesis (GO:0060271)2.86717414
26intraciliary transport (GO:0042073)2.85520845
27histone H2A acetylation (GO:0043968)2.85043500
28epithelial cilium movement (GO:0003351)2.83883027
29regulation of cilium movement (GO:0003352)2.83441514
30regulation of telomere maintenance (GO:0032204)2.81265869
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80556057
32somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80396693
33somatic hypermutation of immunoglobulin genes (GO:0016446)2.80396693
34vocalization behavior (GO:0071625)2.79288697
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.76890030
36calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74462548
37chromatin remodeling at centromere (GO:0031055)2.73045313
38protein polyglutamylation (GO:0018095)2.72358294
39preassembly of GPI anchor in ER membrane (GO:0016254)2.71229114
40somite rostral/caudal axis specification (GO:0032525)2.68535830
41regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.67844111
42GPI anchor metabolic process (GO:0006505)2.66776275
43striatum development (GO:0021756)2.66052097
44microtubule anchoring (GO:0034453)2.65405400
45histone H3-K9 methylation (GO:0051567)2.63507128
46regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61561561
47tongue development (GO:0043586)2.61454442
48DNA catabolic process, exonucleolytic (GO:0000738)2.61280805
49mechanosensory behavior (GO:0007638)2.60981880
50photoreceptor cell maintenance (GO:0045494)2.57378427
51cilium organization (GO:0044782)2.56811467
52regulation of telomere maintenance via telomerase (GO:0032210)2.56684169
53head development (GO:0060322)2.56166484
54regulation of gene silencing by RNA (GO:0060966)2.55719705
55regulation of posttranscriptional gene silencing (GO:0060147)2.55719705
56regulation of gene silencing by miRNA (GO:0060964)2.55719705
57cilium assembly (GO:0042384)2.55601879
58response to pheromone (GO:0019236)2.55249041
59postreplication repair (GO:0006301)2.54297984
60behavioral response to nicotine (GO:0035095)2.53591073
61protein K11-linked deubiquitination (GO:0035871)2.52811895
62negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51708310
63histone exchange (GO:0043486)2.51112438
64somite development (GO:0061053)2.50959303
65regulation of development, heterochronic (GO:0040034)2.50446026
66platelet dense granule organization (GO:0060155)2.49987235
67mRNA splice site selection (GO:0006376)2.46699942
68negative regulation of telomere maintenance (GO:0032205)2.46478159
69synapse assembly (GO:0007416)2.45328774
70regulation of nuclear cell cycle DNA replication (GO:0033262)2.44171904
71CENP-A containing nucleosome assembly (GO:0034080)2.43556542
72C4-dicarboxylate transport (GO:0015740)2.42325237
73DNA replication-dependent nucleosome organization (GO:0034723)2.42150076
74DNA replication-dependent nucleosome assembly (GO:0006335)2.42150076
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.40951719
76regulation of meiosis I (GO:0060631)2.40052184
77translesion synthesis (GO:0019985)2.39563625
78negative regulation of synaptic transmission, GABAergic (GO:0032229)2.39511832
79lung-associated mesenchyme development (GO:0060484)2.39440348
80behavioral response to ethanol (GO:0048149)2.38941855
81cellular response to sterol (GO:0036315)2.37690420
82ubiquinone metabolic process (GO:0006743)2.37166869
83aggressive behavior (GO:0002118)2.36724340
84serotonin metabolic process (GO:0042428)2.33776917
85fatty acid elongation (GO:0030497)2.31900930
86central nervous system projection neuron axonogenesis (GO:0021952)2.31820229
87neurotransmitter-gated ion channel clustering (GO:0072578)2.31343847
88regulation of mitotic spindle checkpoint (GO:1903504)2.31102523
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31102523
90regulation of sarcomere organization (GO:0060297)2.30908905
91recombinational repair (GO:0000725)2.29987031
92DNA demethylation (GO:0080111)2.29310937
93intra-S DNA damage checkpoint (GO:0031573)2.28809683
94retinal ganglion cell axon guidance (GO:0031290)2.28582748
95hindbrain development (GO:0030902)2.28396040
96forebrain neuron differentiation (GO:0021879)2.28221811
97cilium movement (GO:0003341)2.27957606
98neuronal stem cell maintenance (GO:0097150)2.27742759
99reflex (GO:0060004)2.27387362
100regulation of centriole replication (GO:0046599)2.26556169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.66520878
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.28361458
3IGF1R_20145208_ChIP-Seq_DFB_Human3.19783694
4GBX2_23144817_ChIP-Seq_PC3_Human3.06529683
5VDR_22108803_ChIP-Seq_LS180_Human2.83382663
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78822888
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.77866739
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70984273
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67071235
10TAF15_26573619_Chip-Seq_HEK293_Human2.65234753
11EZH2_22144423_ChIP-Seq_EOC_Human2.63432635
12FUS_26573619_Chip-Seq_HEK293_Human2.54221633
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35961703
14P300_19829295_ChIP-Seq_ESCs_Human2.35339848
15EWS_26573619_Chip-Seq_HEK293_Human2.30602749
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21442595
17IRF1_19129219_ChIP-ChIP_H3396_Human2.06771443
18* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00969531
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95530899
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95026684
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.91305057
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88531414
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85057789
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83614872
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83358541
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.80332179
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77702107
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.77307390
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75753691
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72269328
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67140383
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.66194679
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.64733170
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63420062
35SMAD4_21799915_ChIP-Seq_A2780_Human1.60475402
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54431895
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51751668
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.50659722
39ER_23166858_ChIP-Seq_MCF-7_Human1.49729654
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49385260
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.46710544
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46520285
43CBP_20019798_ChIP-Seq_JUKART_Human1.46012453
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46012453
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44624704
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43755036
47ELK1_19687146_ChIP-ChIP_HELA_Human1.42962250
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42330209
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42330209
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41124553
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38393876
52STAT3_23295773_ChIP-Seq_U87_Human1.38075157
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37636709
54AR_25329375_ChIP-Seq_VCAP_Human1.36231992
55TCF4_23295773_ChIP-Seq_U87_Human1.35899037
56RUNX2_22187159_ChIP-Seq_PCA_Human1.33560750
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29003141
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.28184020
59BCAT_22108803_ChIP-Seq_LS180_Human1.27807901
60* MYC_18940864_ChIP-ChIP_HL60_Human1.26516489
61RNF2_27304074_Chip-Seq_NSC_Mouse1.26379561
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19999154
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17988085
64TCF4_22108803_ChIP-Seq_LS180_Human1.17482222
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17419714
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16251209
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.16233693
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16189198
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.15648032
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.14374455
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13555102
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11373611
73NANOG_19829295_ChIP-Seq_ESCs_Human1.09447790
74SOX2_19829295_ChIP-Seq_ESCs_Human1.09447790
75REST_21632747_ChIP-Seq_MESCs_Mouse1.09425601
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08992133
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08548560
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.08160424
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07729136
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.06992483
81TP53_22573176_ChIP-Seq_HFKS_Human1.06857065
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04555565
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.03918235
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03606377
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03039092
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02893323
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02152917
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01877630
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.00055193
90TAL1_26923725_Chip-Seq_HPCs_Mouse0.99264494
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97375331
92SOX9_26525672_Chip-Seq_HEART_Mouse0.96936883
93VDR_23849224_ChIP-Seq_CD4+_Human0.95900583
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.95743373
95P53_22387025_ChIP-Seq_ESCs_Mouse0.95646796
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.95484867
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.93518801
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92777594
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.91995193
100AR_21572438_ChIP-Seq_LNCaP_Human0.91868680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.22721296
2MP0008877_abnormal_DNA_methylation3.16018572
3MP0003880_abnormal_central_pattern2.97686862
4MP0006292_abnormal_olfactory_placode2.96630612
5MP0003787_abnormal_imprinting2.69528782
6MP0001529_abnormal_vocalization2.34308044
7MP0003136_yellow_coat_color2.25999220
8MP0003890_abnormal_embryonic-extraembry2.19692811
9MP0002653_abnormal_ependyma_morphology2.14480711
10MP0001486_abnormal_startle_reflex2.12351351
11MP0003121_genomic_imprinting2.07432269
12MP0008789_abnormal_olfactory_epithelium2.04730200
13MP0006072_abnormal_retinal_apoptosis1.97900302
14MP0001984_abnormal_olfaction1.95782315
15MP0005423_abnormal_somatic_nervous1.94003714
16MP0001968_abnormal_touch/_nociception1.92617129
17MP0000778_abnormal_nervous_system1.90574791
18MP0008058_abnormal_DNA_repair1.88601909
19MP0002736_abnormal_nociception_after1.84733699
20MP0005394_taste/olfaction_phenotype1.84233524
21MP0005499_abnormal_olfactory_system1.84233524
22MP0001293_anophthalmia1.84227888
23MP0001188_hyperpigmentation1.82359245
24MP0004133_heterotaxia1.76718613
25MP0006276_abnormal_autonomic_nervous1.74749273
26MP0002735_abnormal_chemical_nociception1.65544698
27MP0002751_abnormal_autonomic_nervous1.63818752
28MP0003119_abnormal_digestive_system1.61554388
29MP0000566_synostosis1.61472889
30MP0005253_abnormal_eye_physiology1.59333385
31MP0002837_dystrophic_cardiac_calcinosis1.57310452
32MP0001986_abnormal_taste_sensitivity1.55354047
33MP0005551_abnormal_eye_electrophysiolog1.53162718
34MP0002234_abnormal_pharynx_morphology1.49109853
35MP0000631_abnormal_neuroendocrine_gland1.48868428
36MP0003122_maternal_imprinting1.48437156
37MP0002938_white_spotting1.41758278
38MP0002233_abnormal_nose_morphology1.41646286
39MP0005646_abnormal_pituitary_gland1.36849574
40MP0004215_abnormal_myocardial_fiber1.35945391
41MP0000049_abnormal_middle_ear1.35514029
42MP0003937_abnormal_limbs/digits/tail_de1.35133473
43MP0009745_abnormal_behavioral_response1.33001589
44MP0002572_abnormal_emotion/affect_behav1.30692757
45MP0001177_atelectasis1.30059990
46MP0000569_abnormal_digit_pigmentation1.28704131
47MP0001299_abnormal_eye_distance/1.25816818
48MP0003635_abnormal_synaptic_transmissio1.24511670
49MP0004859_abnormal_synaptic_plasticity1.24019802
50MP0003646_muscle_fatigue1.22106315
51MP0000427_abnormal_hair_cycle1.19788619
52MP0000383_abnormal_hair_follicle1.18664286
53MP0002063_abnormal_learning/memory/cond1.17165387
54MP0002734_abnormal_mechanical_nocicepti1.14815177
55MP0010094_abnormal_chromosome_stability1.12979469
56MP0002272_abnormal_nervous_system1.12659851
57MP0003718_maternal_effect1.11478900
58MP0008057_abnormal_DNA_replication1.11381672
59MP0005645_abnormal_hypothalamus_physiol1.09610946
60MP0002557_abnormal_social/conspecific_i1.08921864
61MP0009046_muscle_twitch1.06053444
62MP0001485_abnormal_pinna_reflex1.05649948
63MP0002067_abnormal_sensory_capabilities1.04218442
64MP0002184_abnormal_innervation1.03523452
65MP0003137_abnormal_impulse_conducting1.03498665
66MP0005391_vision/eye_phenotype1.03279363
67MP0002127_abnormal_cardiovascular_syste0.98552082
68MP0003011_delayed_dark_adaptation0.98332252
69MP0003755_abnormal_palate_morphology0.94993202
70MP0003567_abnormal_fetal_cardiomyocyte0.94884802
71MP0010030_abnormal_orbit_morphology0.94220140
72MP0002064_seizures0.94130193
73MP0002638_abnormal_pupillary_reflex0.93936790
74MP0003861_abnormal_nervous_system0.93231918
75MP0000955_abnormal_spinal_cord0.92249329
76MP0001286_abnormal_eye_development0.91755788
77MP0006054_spinal_hemorrhage0.90437816
78MP0002752_abnormal_somatic_nervous0.89810716
79MP0000647_abnormal_sebaceous_gland0.89254447
80MP0002822_catalepsy0.89192958
81MP0005248_abnormal_Harderian_gland0.88191122
82MP0005386_behavior/neurological_phenoty0.85889246
83MP0004924_abnormal_behavior0.85889246
84MP0003693_abnormal_embryo_hatching0.85854653
85MP0003698_abnormal_male_reproductive0.83080096
86MP0004085_abnormal_heartbeat0.82817317
87MP0002282_abnormal_trachea_morphology0.82335539
88MP0004270_analgesia0.80926750
89MP0002152_abnormal_brain_morphology0.80727677
90MP0001929_abnormal_gametogenesis0.80435213
91MP0004885_abnormal_endolymph0.77352534
92MP0005084_abnormal_gallbladder_morpholo0.76992746
93MP0009703_decreased_birth_body0.75948032
94MP0004142_abnormal_muscle_tone0.75000702
95MP0000026_abnormal_inner_ear0.74855620
96MP0003938_abnormal_ear_development0.74591498
97MP0002697_abnormal_eye_size0.74297178
98MP0002882_abnormal_neuron_morphology0.73209172
99MP0001963_abnormal_hearing_physiology0.72666893
100MP0005195_abnormal_posterior_eye0.72081671

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.65201172
2True hermaphroditism (HP:0010459)3.45980443
3Abnormality of the labia minora (HP:0012880)3.34411353
4Pancreatic fibrosis (HP:0100732)3.29518982
5Methylmalonic acidemia (HP:0002912)3.06020804
6Medial flaring of the eyebrow (HP:0010747)3.03254216
7Nephronophthisis (HP:0000090)2.84607953
8Colon cancer (HP:0003003)2.80121872
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.78978532
10Chronic hepatic failure (HP:0100626)2.76339905
11Meckel diverticulum (HP:0002245)2.64799347
12Hyperventilation (HP:0002883)2.64405281
13Hyperglycinuria (HP:0003108)2.63121304
14Abnormality of midbrain morphology (HP:0002418)2.60851907
15Molar tooth sign on MRI (HP:0002419)2.60851907
16Abnormal biliary tract physiology (HP:0012439)2.56275680
17Bile duct proliferation (HP:0001408)2.56275680
18Abnormality of the ileum (HP:0001549)2.54071827
19Gait imbalance (HP:0002141)2.52757436
20Renal cortical cysts (HP:0000803)2.51863258
21Tubulointerstitial nephritis (HP:0001970)2.50481950
22Abnormality of the renal medulla (HP:0100957)2.44746984
23Broad-based gait (HP:0002136)2.43571027
24Hyperglycinemia (HP:0002154)2.42702466
25Congenital primary aphakia (HP:0007707)2.41714750
26Abnormality of the renal cortex (HP:0011035)2.40033189
27Abnormality of chromosome stability (HP:0003220)2.40030225
28Intestinal atresia (HP:0011100)2.36406931
29Gonadotropin excess (HP:0000837)2.33916172
30High anterior hairline (HP:0009890)2.32748103
31Abnormality of glycine metabolism (HP:0010895)2.32120903
32Abnormality of serine family amino acid metabolism (HP:0010894)2.32120903
33Cystic liver disease (HP:0006706)2.31702780
34Genital tract atresia (HP:0001827)2.27057358
35Vaginal atresia (HP:0000148)2.23973447
36Cortical dysplasia (HP:0002539)2.22414840
37Congenital stationary night blindness (HP:0007642)2.22337837
38Septo-optic dysplasia (HP:0100842)2.19852191
39Sclerocornea (HP:0000647)2.19286461
40Focal motor seizures (HP:0011153)2.17743274
41Thyroid-stimulating hormone excess (HP:0002925)2.13774722
42Nephrogenic diabetes insipidus (HP:0009806)2.13744937
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.13467540
44Protruding tongue (HP:0010808)2.12677358
45Hemiparesis (HP:0001269)2.12477890
46Methylmalonic aciduria (HP:0012120)2.10951256
47Inability to walk (HP:0002540)2.09435613
48Progressive inability to walk (HP:0002505)2.09100007
49Anencephaly (HP:0002323)2.05584304
50Chromsome breakage (HP:0040012)2.03542601
51Limb dystonia (HP:0002451)2.02339540
52Broad foot (HP:0001769)2.00933460
53Postaxial hand polydactyly (HP:0001162)2.00675127
54Atonic seizures (HP:0010819)1.99961663
55Clubbing of toes (HP:0100760)1.98070970
56Dandy-Walker malformation (HP:0001305)1.96608142
57Drooling (HP:0002307)1.95223893
58Postaxial foot polydactyly (HP:0001830)1.93995506
59Polyphagia (HP:0002591)1.93807511
60Lissencephaly (HP:0001339)1.93561848
61Small intestinal stenosis (HP:0012848)1.93013219
62Duodenal stenosis (HP:0100867)1.93013219
633-Methylglutaconic aciduria (HP:0003535)1.91486919
64Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90630990
65Stomach cancer (HP:0012126)1.90251767
66Abnormality of the vitamin B12 metabolism (HP:0004341)1.85119361
67Hepatoblastoma (HP:0002884)1.85012089
68Abnormality of the duodenum (HP:0002246)1.84316886
69Astigmatism (HP:0000483)1.84204512
70Preaxial hand polydactyly (HP:0001177)1.83319307
71Abolished electroretinogram (ERG) (HP:0000550)1.82914096
72Progressive cerebellar ataxia (HP:0002073)1.82637299
73Abnormality of vitamin B metabolism (HP:0004340)1.81079748
74Specific learning disability (HP:0001328)1.80923591
75Absent speech (HP:0001344)1.80018006
76Abnormality of the preputium (HP:0100587)1.78317851
77Growth hormone deficiency (HP:0000824)1.76885835
78Aplasia/Hypoplasia of the tibia (HP:0005772)1.76424481
79Rib fusion (HP:0000902)1.76325639
80Febrile seizures (HP:0002373)1.76071619
81Gastroesophageal reflux (HP:0002020)1.75968206
82Abnormality of alanine metabolism (HP:0010916)1.75897344
83Hyperalaninemia (HP:0003348)1.75897344
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75897344
85Congenital hepatic fibrosis (HP:0002612)1.74592430
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74386784
87Optic nerve hypoplasia (HP:0000609)1.74236189
88Abnormality of the carotid arteries (HP:0005344)1.73704649
89Dialeptic seizures (HP:0011146)1.73333089
90Genetic anticipation (HP:0003743)1.72057950
91Poor coordination (HP:0002370)1.71831769
92Excessive salivation (HP:0003781)1.71734491
93Focal seizures (HP:0007359)1.71472987
94Narrow forehead (HP:0000341)1.70840792
95Pachygyria (HP:0001302)1.69531781
96Carpal bone hypoplasia (HP:0001498)1.69340369
97Triphalangeal thumb (HP:0001199)1.68332771
98Anophthalmia (HP:0000528)1.67745126
99Tented upper lip vermilion (HP:0010804)1.67441103
100Sloping forehead (HP:0000340)1.66749128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.39889193
2CASK2.91960453
3MAP3K42.84252998
4FRK2.45670911
5MAP4K22.41453644
6MKNK22.37770304
7MARK12.28347195
8NUAK12.28319769
9SRPK12.27194151
10BMPR1B2.18401169
11MAP2K72.00457767
12MKNK12.00248637
13TRIM281.96863483
14TNIK1.88147853
15GRK11.84427472
16ACVR1B1.82027309
17MAPK131.78564650
18ERBB31.74090444
19DYRK21.62230222
20RPS6KA41.54909980
21VRK11.48059263
22EPHA41.45415885
23DYRK31.44694938
24BRD41.42552601
25BRSK21.41952890
26VRK21.38203290
27BCR1.37612327
28PLK41.36481783
29ZAK1.28155838
30CSNK1G21.20393559
31PRKCE1.19306230
32PLK31.18793264
33PINK11.17822946
34LATS11.17174635
35TGFBR11.16899276
36PLK21.14280928
37NTRK21.12581268
38CDK191.11107051
39DAPK21.10856240
40CDC71.07993776
41TTK1.07903903
42PNCK1.07003446
43TSSK61.06769348
44ERBB41.06623319
45ADRBK21.04905584
46STK38L1.04000405
47TIE11.03878588
48INSRR1.01876909
49CSNK1G11.01558895
50BCKDK0.98525824
51TESK20.92009841
52FGFR20.90640738
53PAK30.87721101
54MAP2K40.86596233
55AKT30.86419741
56DYRK1A0.85646372
57CAMKK20.84529575
58UHMK10.82278857
59IRAK10.82228760
60STK390.81476460
61CSNK1G30.80218884
62EIF2AK30.79660357
63OBSCN0.77415385
64OXSR10.75978947
65PRKCG0.75260707
66CSNK1A1L0.72881121
67PLK10.72718500
68PKN10.72520733
69SGK20.70647433
70SGK2230.69014555
71SGK4940.69014555
72ATR0.63780783
73ATM0.63356133
74TAF10.61307666
75WNK40.60608160
76FER0.59717308
77CAMK1G0.57033686
78CDK30.56592201
79CAMK2A0.56567926
80CCNB10.55556596
81STK160.54911785
82NLK0.51277311
83PBK0.51101659
84BUB10.46261682
85CSNK1D0.44953131
86STK30.44619972
87MAPK150.42730303
88EPHA30.41126571
89CAMK2B0.40836953
90RPS6KA50.39812156
91CAMK1D0.38717469
92MST40.37785751
93CDK50.36915503
94PRKACA0.35572936
95PRKG10.34139173
96PRKACB0.33684830
97PRKDC0.32956917
98BRSK10.32558375
99MINK10.32169836
100PIK3CA0.31028488

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.07115344
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.88531010
3Nicotine addiction_Homo sapiens_hsa050332.73857255
4Propanoate metabolism_Homo sapiens_hsa006402.71777856
5Phototransduction_Homo sapiens_hsa047442.70833491
6Fanconi anemia pathway_Homo sapiens_hsa034602.61443893
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37621541
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19153855
9Butanoate metabolism_Homo sapiens_hsa006502.00138917
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99206620
11Homologous recombination_Homo sapiens_hsa034401.88185774
12RNA polymerase_Homo sapiens_hsa030201.80361032
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77685557
14Protein export_Homo sapiens_hsa030601.76513224
15Taste transduction_Homo sapiens_hsa047421.73262357
16RNA degradation_Homo sapiens_hsa030181.69939034
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66570551
18Selenocompound metabolism_Homo sapiens_hsa004501.59349629
19Steroid biosynthesis_Homo sapiens_hsa001001.53236729
20Base excision repair_Homo sapiens_hsa034101.50976207
21Basal transcription factors_Homo sapiens_hsa030221.50925218
22GABAergic synapse_Homo sapiens_hsa047271.48657088
23Linoleic acid metabolism_Homo sapiens_hsa005911.47958901
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46312577
25Nitrogen metabolism_Homo sapiens_hsa009101.45647493
26Fatty acid elongation_Homo sapiens_hsa000621.44206695
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.42086080
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38800283
29Mismatch repair_Homo sapiens_hsa034301.37892970
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34484995
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32422495
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29702213
33Ether lipid metabolism_Homo sapiens_hsa005651.28041837
34RNA transport_Homo sapiens_hsa030131.27620906
35Circadian entrainment_Homo sapiens_hsa047131.20692456
36Morphine addiction_Homo sapiens_hsa050321.18437150
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17943506
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14536003
39Glutamatergic synapse_Homo sapiens_hsa047241.13567554
40mRNA surveillance pathway_Homo sapiens_hsa030151.09516461
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.06691688
42Serotonergic synapse_Homo sapiens_hsa047261.06267363
43Spliceosome_Homo sapiens_hsa030401.05723867
44Dopaminergic synapse_Homo sapiens_hsa047281.02822864
45DNA replication_Homo sapiens_hsa030301.01386729
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00551260
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97618206
48Lysine degradation_Homo sapiens_hsa003100.97590555
49Oxidative phosphorylation_Homo sapiens_hsa001900.95349502
50Amphetamine addiction_Homo sapiens_hsa050310.93888576
51Olfactory transduction_Homo sapiens_hsa047400.92843662
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89975775
53beta-Alanine metabolism_Homo sapiens_hsa004100.89089489
54Hedgehog signaling pathway_Homo sapiens_hsa043400.89067044
55Purine metabolism_Homo sapiens_hsa002300.88761591
56Regulation of autophagy_Homo sapiens_hsa041400.88389830
57Tryptophan metabolism_Homo sapiens_hsa003800.88193494
58Peroxisome_Homo sapiens_hsa041460.85111693
59One carbon pool by folate_Homo sapiens_hsa006700.84831586
60Long-term depression_Homo sapiens_hsa047300.84724297
61Parkinsons disease_Homo sapiens_hsa050120.81484532
62Cocaine addiction_Homo sapiens_hsa050300.80935530
63Circadian rhythm_Homo sapiens_hsa047100.80912528
64Fatty acid metabolism_Homo sapiens_hsa012120.78715977
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77803862
66Pyrimidine metabolism_Homo sapiens_hsa002400.76114389
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75098416
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72642762
69Nucleotide excision repair_Homo sapiens_hsa034200.68847399
70Oocyte meiosis_Homo sapiens_hsa041140.68572310
71Dorso-ventral axis formation_Homo sapiens_hsa043200.68481080
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65982219
73Insulin secretion_Homo sapiens_hsa049110.65498014
74Fatty acid degradation_Homo sapiens_hsa000710.63756528
75Huntingtons disease_Homo sapiens_hsa050160.63596203
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63563478
77Pyruvate metabolism_Homo sapiens_hsa006200.63211478
78Basal cell carcinoma_Homo sapiens_hsa052170.62451833
79TGF-beta signaling pathway_Homo sapiens_hsa043500.62000521
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60500630
81Hippo signaling pathway_Homo sapiens_hsa043900.58308344
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56108416
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54828017
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52904332
85Metabolic pathways_Homo sapiens_hsa011000.52216549
86Wnt signaling pathway_Homo sapiens_hsa043100.50419880
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49916644
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49615631
89Retinol metabolism_Homo sapiens_hsa008300.48585498
90Alcoholism_Homo sapiens_hsa050340.48404306
91Calcium signaling pathway_Homo sapiens_hsa040200.47238508
92Salivary secretion_Homo sapiens_hsa049700.46675416
93Caffeine metabolism_Homo sapiens_hsa002320.45358136
94Histidine metabolism_Homo sapiens_hsa003400.43956011
95Cardiac muscle contraction_Homo sapiens_hsa042600.42809760
96Axon guidance_Homo sapiens_hsa043600.39904148
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39584272
98Chemical carcinogenesis_Homo sapiens_hsa052040.39377830
99Cell cycle_Homo sapiens_hsa041100.38698915
100Glycerolipid metabolism_Homo sapiens_hsa005610.38290223

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