ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.39879060
2	response to pheromone (GO:0019236)	3.91612473
3	nonmotile primary cilium assembly (GO:0035058)	3.63536160
4	epithelial cilium movement (GO:0003351)	3.61861167
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.57342942
6	gamma-aminobutyric acid transport (GO:0015812)	3.50941926
7	water-soluble vitamin biosynthetic process (GO:0042364)	3.47481429
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.38490221
9	L-fucose catabolic process (GO:0042355)	3.33538105
10	fucose catabolic process (GO:0019317)	3.33538105
11	L-fucose metabolic process (GO:0042354)	3.33538105
12	piRNA metabolic process (GO:0034587)	3.24214585
13	indolalkylamine metabolic process (GO:0006586)	3.22400088
14	somite development (GO:0061053)	3.12998183
15	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.07460441
16	pyrimidine nucleobase catabolic process (GO:0006208)	3.05665693
17	tryptophan catabolic process (GO:0006569)	3.05479943
18	indole-containing compound catabolic process (GO:0042436)	3.05479943
19	indolalkylamine catabolic process (GO:0046218)	3.05479943
20	kynurenine metabolic process (GO:0070189)	3.02913240
21	cilium movement (GO:0003341)	3.02352022
22	protein localization to cilium (GO:0061512)	3.02195036
23	DNA deamination (GO:0045006)	3.01523441
24	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.90634768
25	kidney morphogenesis (GO:0060993)	2.89293439
26	transmission of nerve impulse (GO:0019226)	2.88512039
27	intraciliary transport (GO:0042073)	2.87450152
28	protein complex biogenesis (GO:0070271)	2.86512124
29	cilium morphogenesis (GO:0060271)	2.86489282
30	presynaptic membrane assembly (GO:0097105)	2.84457952
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.82497468
32	NADH dehydrogenase complex assembly (GO:0010257)	2.82497468
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.82497468
34	negative regulation of telomere maintenance (GO:0032205)	2.81358216
35	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.80278153
36	cell proliferation in forebrain (GO:0021846)	2.78036472
37	dendritic spine morphogenesis (GO:0060997)	2.77060063
38	axoneme assembly (GO:0035082)	2.75333846
39	retinal ganglion cell axon guidance (GO:0031290)	2.75262975
40	nephron tubule morphogenesis (GO:0072078)	2.74581502
41	nephron epithelium morphogenesis (GO:0072088)	2.74581502
42	neuron fate determination (GO:0048664)	2.74363175
43	detection of light stimulus involved in visual perception (GO:0050908)	2.73189005
44	detection of light stimulus involved in sensory perception (GO:0050962)	2.73189005
45	synaptic transmission, cholinergic (GO:0007271)	2.73124934
46	preassembly of GPI anchor in ER membrane (GO:0016254)	2.72557537
47	neural tube formation (GO:0001841)	2.71908546
48	protein polyglutamylation (GO:0018095)	2.69180043
49	regulation of telomere maintenance (GO:0032204)	2.68980301
50	cilium organization (GO:0044782)	2.67299143
51	reflex (GO:0060004)	2.67267640
52	retinal cone cell development (GO:0046549)	2.65989831
53	regulation of action potential (GO:0098900)	2.65143520
54	spinal cord motor neuron differentiation (GO:0021522)	2.64421839
55	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.63792274
56	mitochondrial respiratory chain complex assembly (GO:0033108)	2.63580404
57	postsynaptic membrane organization (GO:0001941)	2.63347408
58	presynaptic membrane organization (GO:0097090)	2.63103230
59	respiratory chain complex IV assembly (GO:0008535)	2.62991031
60	tachykinin receptor signaling pathway (GO:0007217)	2.62826428
61	DNA methylation involved in gamete generation (GO:0043046)	2.62719094
62	nucleobase catabolic process (GO:0046113)	2.61761329
63	cellular ketone body metabolic process (GO:0046950)	2.61730150
64	neuronal action potential (GO:0019228)	2.60239025
65	multicellular organism reproduction (GO:0032504)	2.60187184
66	regulation of gene silencing by RNA (GO:0060966)	2.59257393
67	regulation of posttranscriptional gene silencing (GO:0060147)	2.59257393
68	regulation of gene silencing by miRNA (GO:0060964)	2.59257393
69	cilium assembly (GO:0042384)	2.58695824
70	sulfation (GO:0051923)	2.57927585
71	glycerophospholipid catabolic process (GO:0046475)	2.57654332
72	photoreceptor cell development (GO:0042461)	2.56584912
73	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.55805552
74	cornea development in camera-type eye (GO:0061303)	2.55265792
75	negative regulation of systemic arterial blood pressure (GO:0003085)	2.53657979
76	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52904398
77	appendage development (GO:0048736)	2.50550270
78	limb development (GO:0060173)	2.50550270
79	behavioral response to ethanol (GO:0048149)	2.50020241
80	startle response (GO:0001964)	2.49854776
81	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.48602343
82	indole-containing compound metabolic process (GO:0042430)	2.48540750
83	cAMP catabolic process (GO:0006198)	2.47810484
84	amine catabolic process (GO:0009310)	2.47775101
85	cellular biogenic amine catabolic process (GO:0042402)	2.47775101
86	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.47656460
87	rhodopsin mediated signaling pathway (GO:0016056)	2.46720638
88	tryptophan metabolic process (GO:0006568)	2.46648915
89	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.46387040
90	negative regulation of mast cell activation (GO:0033004)	2.45563310
91	male meiosis I (GO:0007141)	2.45025197
92	regulation of cilium movement (GO:0003352)	2.44394078
93	regulation of meiosis I (GO:0060631)	2.42802990
94	primary amino compound metabolic process (GO:1901160)	2.41846546
95	reciprocal DNA recombination (GO:0035825)	2.40029568
96	reciprocal meiotic recombination (GO:0007131)	2.40029568
97	photoreceptor cell maintenance (GO:0045494)	2.39819750
98	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.39613114
99	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.39613114
100	regulation of translation, ncRNA-mediated (GO:0045974)	2.39613114

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.87810352
2	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.68892665
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.93170927
4	VDR_22108803_ChIP-Seq_LS180_Human	2.89470820
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.82184823
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.66295182
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47046839
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27394092
9	FUS_26573619_Chip-Seq_HEK293_Human	2.14876639
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12421318
11	EWS_26573619_Chip-Seq_HEK293_Human	2.12120338
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09302966
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02837020
14	IGF1R_20145208_ChIP-Seq_DFB_Human	1.98498045
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.97577051
16	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97445765
17	P300_19829295_ChIP-Seq_ESCs_Human	1.93872771
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.93270417
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.89028052
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88740540
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.88033304
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.77651607
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.76861590
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71065043
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.66534845
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.63023617
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62951478
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60139805
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56588174
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55193392
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53877097
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53845467
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53538443
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53538443
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53064005
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52482655
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51765584
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.51680317
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51640913
40	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.50893608
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49311451
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48950349
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.48219889
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48219889
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47653434
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.46934929
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46005006
48	STAT3_23295773_ChIP-Seq_U87_Human	1.42186537
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.40600730
50	AR_25329375_ChIP-Seq_VCAP_Human	1.40141200
51	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.40084220
52	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.39072497
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37931619
54	TCF4_23295773_ChIP-Seq_U87_Human	1.37283308
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.35664793
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34889531
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32996961
58	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.31762958
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29295373
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29008214
61	AR_21572438_ChIP-Seq_LNCaP_Human	1.28152780
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27982169
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26657181
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.25131910
65	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23328813
66	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.21516277
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21364244
68	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.20789038
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16795961
70	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.16109768
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15985364
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.15420230
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14641374
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13322458
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13322458
76	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10962346
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.10492443
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10305824
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09618629
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09618348
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07974291
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07830437
83	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07716987
84	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.06558772
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06495110
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06495110
87	NCOR_22424771_ChIP-Seq_293T_Human	1.06340412
88	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05799215
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05093135
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04242403
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02948476
92	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02589332
93	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02367707
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.00761430
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00750275
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00359704
97	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.99074725
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97811556
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96864948
100	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.96717676

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.03200338
2	MP0008877_abnormal_DNA_methylation	2.93556655
3	MP0003136_yellow_coat_color	2.64417290
4	MP0002102_abnormal_ear_morphology	2.59230810
5	MP0002653_abnormal_ependyma_morphology	2.36882179
6	MP0005551_abnormal_eye_electrophysiolog	2.31698424
7	MP0003787_abnormal_imprinting	2.30586830
8	MP0004142_abnormal_muscle_tone	2.14684344
9	MP0003195_calcinosis	2.11974567
10	MP0001968_abnormal_touch/_nociception	2.06764754
11	MP0003646_muscle_fatigue	2.06062533
12	MP0003880_abnormal_central_pattern	1.98069149
13	MP0006072_abnormal_retinal_apoptosis	1.97234541
14	MP0002638_abnormal_pupillary_reflex	1.95575292
15	MP0005645_abnormal_hypothalamus_physiol	1.94518518
16	MP0006276_abnormal_autonomic_nervous	1.92187290
17	MP0005646_abnormal_pituitary_gland	1.90550004
18	MP0000569_abnormal_digit_pigmentation	1.86351958
19	MP0009745_abnormal_behavioral_response	1.83222486
20	MP0000631_abnormal_neuroendocrine_gland	1.79631430
21	MP0002837_dystrophic_cardiac_calcinosis	1.79078042
22	MP0002938_white_spotting	1.75243274
23	MP0004885_abnormal_endolymph	1.72009675
24	MP0002272_abnormal_nervous_system	1.70328264
25	MP0002736_abnormal_nociception_after	1.70204528
26	MP0005253_abnormal_eye_physiology	1.67719431
27	MP0003011_delayed_dark_adaptation	1.66795329
28	MP0009046_muscle_twitch	1.66149919
29	MP0001984_abnormal_olfaction	1.61253905
30	MP0004133_heterotaxia	1.60791687
31	MP0000778_abnormal_nervous_system	1.58812872
32	MP0001986_abnormal_taste_sensitivity	1.51424232
33	MP0003121_genomic_imprinting	1.50015455
34	MP0000372_irregular_coat_pigmentation	1.44214212
35	MP0003890_abnormal_embryonic-extraembry	1.43310208
36	MP0003122_maternal_imprinting	1.42438681
37	MP0002822_catalepsy	1.41648942
38	MP0002557_abnormal_social/conspecific_i	1.41101464
39	MP0002572_abnormal_emotion/affect_behav	1.39436131
40	MP0001485_abnormal_pinna_reflex	1.39252151
41	MP0008789_abnormal_olfactory_epithelium	1.36988845
42	MP0001486_abnormal_startle_reflex	1.36788474
43	MP0008872_abnormal_physiological_respon	1.35304377
44	MP0004043_abnormal_pH_regulation	1.33866024
45	MP0001188_hyperpigmentation	1.33346674
46	MP0000427_abnormal_hair_cycle	1.32941778
47	MP0002064_seizures	1.32279012
48	MP0003635_abnormal_synaptic_transmissio	1.31066832
49	MP0002234_abnormal_pharynx_morphology	1.31051849
50	MP0002735_abnormal_chemical_nociception	1.28661133
51	MP0002063_abnormal_learning/memory/cond	1.28243412
52	MP0008995_early_reproductive_senescence	1.25028052
53	MP0002160_abnormal_reproductive_system	1.24364511
54	MP0001529_abnormal_vocalization	1.23466745
55	MP0001501_abnormal_sleep_pattern	1.22717744
56	MP0003718_maternal_effect	1.22454904
57	MP0002163_abnormal_gland_morphology	1.22342343
58	MP0004147_increased_porphyrin_level	1.20194107
59	MP0002876_abnormal_thyroid_physiology	1.18398712
60	MP0002067_abnormal_sensory_capabilities	1.18015184
61	MP0005084_abnormal_gallbladder_morpholo	1.16651968
62	MP0002734_abnormal_mechanical_nocicepti	1.16246234
63	MP0004742_abnormal_vestibular_system	1.15829242
64	MP0002928_abnormal_bile_duct	1.15001990
65	MP0005195_abnormal_posterior_eye	1.14961789
66	MP0001970_abnormal_pain_threshold	1.14601107
67	MP0002277_abnormal_respiratory_mucosa	1.14182592
68	MP0000026_abnormal_inner_ear	1.14003647
69	MP0002751_abnormal_autonomic_nervous	1.13391136
70	MP0005423_abnormal_somatic_nervous	1.12831642
71	MP0002184_abnormal_innervation	1.10457413
72	MP0002752_abnormal_somatic_nervous	1.09676771
73	MP0000049_abnormal_middle_ear	1.08900282
74	MP0001293_anophthalmia	1.08782272
75	MP0008875_abnormal_xenobiotic_pharmacok	1.08389312
76	MP0005389_reproductive_system_phenotype	1.08121208
77	MP0004145_abnormal_muscle_electrophysio	1.07265682
78	MP0002733_abnormal_thermal_nociception	1.06778079
79	MP0003283_abnormal_digestive_organ	1.06514906
80	MP0001502_abnormal_circadian_rhythm	1.04153252
81	MP0005174_abnormal_tail_pigmentation	1.04044843
82	MP0005394_taste/olfaction_phenotype	1.02551264
83	MP0005499_abnormal_olfactory_system	1.02551264
84	MP0003937_abnormal_limbs/digits/tail_de	1.01762776
85	MP0005386_behavior/neurological_phenoty	1.00095661
86	MP0004924_abnormal_behavior	1.00095661
87	MP0001905_abnormal_dopamine_level	0.99977881
88	MP0002095_abnormal_skin_pigmentation	0.99421638
89	MP0004130_abnormal_muscle_cell	0.94890881
90	MP0003119_abnormal_digestive_system	0.94233647
91	MP0001963_abnormal_hearing_physiology	0.91089476
92	MP0010386_abnormal_urinary_bladder	0.90557971
93	MP0002138_abnormal_hepatobiliary_system	0.90042188
94	MP0000955_abnormal_spinal_cord	0.89993295
95	MP0005379_endocrine/exocrine_gland_phen	0.89717831
96	MP0002882_abnormal_neuron_morphology	0.87136815
97	MP0003938_abnormal_ear_development	0.84388348
98	MP0002210_abnormal_sex_determination	0.84366958
99	MP0001440_abnormal_grooming_behavior	0.81509787
100	MP0001324_abnormal_eye_pigmentation	0.79974686

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.46153899
2	Pancreatic fibrosis (HP:0100732)	4.20942042
3	Molar tooth sign on MRI (HP:0002419)	4.10180848
4	Abnormality of midbrain morphology (HP:0002418)	4.10180848
5	True hermaphroditism (HP:0010459)	3.88421718
6	Congenital stationary night blindness (HP:0007642)	3.62140430
7	Nephronophthisis (HP:0000090)	3.57941615
8	Medial flaring of the eyebrow (HP:0010747)	3.43815059
9	Abnormality of the renal medulla (HP:0100957)	3.08480555
10	Chronic hepatic failure (HP:0100626)	3.03756762
11	Gait imbalance (HP:0002141)	3.01059236
12	Type II lissencephaly (HP:0007260)	2.99999968
13	Congenital primary aphakia (HP:0007707)	2.86295425
14	Cystic liver disease (HP:0006706)	2.79797388
15	Abnormality of the renal cortex (HP:0011035)	2.75503313
16	Nephrogenic diabetes insipidus (HP:0009806)	2.71483647
17	Progressive cerebellar ataxia (HP:0002073)	2.70743520
18	Pendular nystagmus (HP:0012043)	2.66384780
19	Hyperventilation (HP:0002883)	2.50467513
20	Abolished electroretinogram (ERG) (HP:0000550)	2.49798763
21	Anencephaly (HP:0002323)	2.49359737
22	Septo-optic dysplasia (HP:0100842)	2.44576145
23	Genital tract atresia (HP:0001827)	2.43085765
24	Oligodactyly (hands) (HP:0001180)	2.41678125
25	Abnormality of the pons (HP:0007361)	2.41598875
26	Hypoplasia of the pons (HP:0012110)	2.41425673
27	Attenuation of retinal blood vessels (HP:0007843)	2.39332914
28	Vaginal atresia (HP:0000148)	2.38781076
29	Sclerocornea (HP:0000647)	2.37220032
30	Genetic anticipation (HP:0003743)	2.35821371
31	Inability to walk (HP:0002540)	2.32808424
32	Tubular atrophy (HP:0000092)	2.32422868
33	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.32171680
34	Large for gestational age (HP:0001520)	2.31873715
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.30594010
36	Optic nerve hypoplasia (HP:0000609)	2.29812844
37	Lissencephaly (HP:0001339)	2.26233135
38	Abnormality of the labia minora (HP:0012880)	2.25826613
39	Poor coordination (HP:0002370)	2.24636820
40	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.23196891
41	Cerebellar dysplasia (HP:0007033)	2.20755292
42	Methylmalonic acidemia (HP:0002912)	2.18163162
43	Broad-based gait (HP:0002136)	2.17190118
44	Progressive inability to walk (HP:0002505)	2.15314773
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.13495676
46	3-Methylglutaconic aciduria (HP:0003535)	2.12585930
47	Concave nail (HP:0001598)	2.10262618
48	Hemiparesis (HP:0001269)	2.09524592
49	Postaxial foot polydactyly (HP:0001830)	2.07902532
50	Agitation (HP:0000713)	2.07030644
51	Abnormal drinking behavior (HP:0030082)	2.05627567
52	Polydipsia (HP:0001959)	2.05627567
53	Postaxial hand polydactyly (HP:0001162)	2.04955972
54	Congenital hepatic fibrosis (HP:0002612)	2.03371032
55	Febrile seizures (HP:0002373)	2.03260210
56	Decreased central vision (HP:0007663)	2.02867710
57	Gaze-evoked nystagmus (HP:0000640)	2.01644443
58	Renal cortical cysts (HP:0000803)	2.01489816
59	Patellar aplasia (HP:0006443)	2.00927557
60	Furrowed tongue (HP:0000221)	2.00632938
61	Supernumerary spleens (HP:0009799)	1.99794369
62	Aplasia/Hypoplasia of the patella (HP:0006498)	1.99328897
63	Male pseudohermaphroditism (HP:0000037)	1.98451980
64	Abnormality of alanine metabolism (HP:0010916)	1.96370668
65	Hyperalaninemia (HP:0003348)	1.96370668
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96370668
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92213797
68	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.91270877
69	Absent/shortened dynein arms (HP:0200106)	1.91270877
70	Short tibia (HP:0005736)	1.90354830
71	Bile duct proliferation (HP:0001408)	1.89996238
72	Abnormal biliary tract physiology (HP:0012439)	1.89996238
73	Hypothermia (HP:0002045)	1.87895288
74	Mitochondrial inheritance (HP:0001427)	1.87526646
75	Limb dystonia (HP:0002451)	1.87521147
76	Abnormal ciliary motility (HP:0012262)	1.87299985
77	Retinal dysplasia (HP:0007973)	1.85441372
78	Acute necrotizing encephalopathy (HP:0006965)	1.85053836
79	Pachygyria (HP:0001302)	1.84757368
80	Intestinal atresia (HP:0011100)	1.83871240
81	Increased corneal curvature (HP:0100692)	1.83162275
82	Keratoconus (HP:0000563)	1.83162275
83	Congenital, generalized hypertrichosis (HP:0004540)	1.82951348
84	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81542409
85	Abnormality of abdominal situs (HP:0011620)	1.79520454
86	Abdominal situs inversus (HP:0003363)	1.79520454
87	Preaxial hand polydactyly (HP:0001177)	1.78730920
88	Anophthalmia (HP:0000528)	1.78692042
89	Specific learning disability (HP:0001328)	1.77062948
90	Methylmalonic aciduria (HP:0012120)	1.76395049
91	Focal motor seizures (HP:0011153)	1.74903617
92	Colon cancer (HP:0003003)	1.74871174
93	Decreased circulating renin level (HP:0003351)	1.74741886
94	Dandy-Walker malformation (HP:0001305)	1.74157425
95	Focal seizures (HP:0007359)	1.73336244
96	Dialeptic seizures (HP:0011146)	1.73123244
97	Bony spicule pigmentary retinopathy (HP:0007737)	1.71592839
98	Thyroid-stimulating hormone excess (HP:0002925)	1.71528702
99	Narrow forehead (HP:0000341)	1.70912409
100	Increased CSF lactate (HP:0002490)	1.70674001

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.94382905
2	TAOK3	2.83931202
3	ADRBK2	2.82840785
4	MAP4K2	2.66258983
5	BMPR1B	2.65244934
6	WNK4	2.57402950
7	CASK	2.53032083
8	GRK1	2.36034305
9	MAP3K4	2.35839611
10	WNK3	2.23844732
11	AKT3	2.15445797
12	ZAK	2.04170294
13	TNIK	2.03429960
14	MAPK13	2.01568952
15	TLK1	1.94879646
16	PINK1	1.93548495
17	STK16	1.92890436
18	NUAK1	1.76106812
19	MAP2K7	1.70343199
20	MARK1	1.70256270
21	ACVR1B	1.65278867
22	DYRK2	1.48593178
23	INSRR	1.38839749
24	PNCK	1.36594817
25	MKNK2	1.31196352
26	PAK3	1.30662401
27	STK39	1.29194415
28	NTRK2	1.21546287
29	CAMKK2	1.06858008
30	EPHA4	1.05539361
31	PRKCG	1.04752338
32	OXSR1	1.03275054
33	NTRK3	1.02588728
34	FGFR2	1.00724747
35	DAPK2	0.99491003
36	ADRBK1	0.95669263
37	TXK	0.91068005
38	TRIM28	0.88453254
39	PRKCE	0.87096758
40	CSNK1G2	0.85643135
41	TGFBR1	0.82533657
42	PLK2	0.78893913
43	CAMK1G	0.78816861
44	VRK1	0.78614364
45	PKN1	0.75956713
46	TIE1	0.75677292
47	CSNK1A1L	0.74917978
48	CAMK1D	0.74838381
49	BCKDK	0.74280580
50	EPHA3	0.73028851
51	CSNK1G1	0.72950594
52	PHKG2	0.72746103
53	PHKG1	0.72746103
54	CSNK1G3	0.71703393
55	NLK	0.71204401
56	MAP2K4	0.66640489
57	SGK2	0.64959199
58	PIK3CA	0.62719351
59	GRK7	0.61596957
60	STK11	0.61312514
61	DYRK3	0.60557746
62	CAMK1	0.59607901
63	BRSK2	0.58568662
64	RPS6KA5	0.58320162
65	CAMK2A	0.56464922
66	MARK3	0.55949199
67	WNK1	0.54250519
68	SIK2	0.54013129
69	MKNK1	0.53633188
70	SGK223	0.53494918
71	SGK494	0.53494918
72	PRKACA	0.53084285
73	MAPKAPK5	0.50398699
74	STK38L	0.50033738
75	IKBKB	0.49887007
76	CHUK	0.48775369
77	CDK19	0.48750735
78	PRKCQ	0.48569679
79	EPHB2	0.48068641
80	DYRK1A	0.45658153
81	PRKCZ	0.44953530
82	PTK2B	0.44748318
83	PRKAA1	0.44548217
84	CSNK1A1	0.44235616
85	PRKCH	0.43993669
86	MAP3K9	0.43436077
87	CDK3	0.42712259
88	TEC	0.42615602
89	MAPK15	0.42386009
90	NME1	0.41725491
91	IRAK1	0.41161930
92	PLK3	0.41034279
93	MAP2K6	0.40866244
94	BRAF	0.40471047
95	PRKCI	0.40335769
96	TNK2	0.39866738
97	ERBB2	0.38878943
98	OBSCN	0.35709790
99	PRKG1	0.35618691
100	TYRO3	0.35403800

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.98513324
2	Phototransduction_Homo sapiens_hsa04744	2.90286795
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.46947967
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.39396209
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.26182588
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.21228413
7	Basal transcription factors_Homo sapiens_hsa03022	2.20813250
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.18276818
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.10115634
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.06903624
11	Protein export_Homo sapiens_hsa03060	1.98351642
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.94488281
13	Homologous recombination_Homo sapiens_hsa03440	1.94004116
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91310705
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90355072
16	Butanoate metabolism_Homo sapiens_hsa00650	1.86471961
17	Parkinsons disease_Homo sapiens_hsa05012	1.84877174
18	RNA polymerase_Homo sapiens_hsa03020	1.78804243
19	Morphine addiction_Homo sapiens_hsa05032	1.73949769
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68189864
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.64267374
22	Taste transduction_Homo sapiens_hsa04742	1.60204409
23	Caffeine metabolism_Homo sapiens_hsa00232	1.57879755
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56405902
25	RNA degradation_Homo sapiens_hsa03018	1.53743058
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51534308
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.50556672
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.44970855
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.43355571
30	GABAergic synapse_Homo sapiens_hsa04727	1.43241442
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38450357
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.37838158
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.37637661
34	Huntingtons disease_Homo sapiens_hsa05016	1.34063905
35	Insulin secretion_Homo sapiens_hsa04911	1.30243081
36	Olfactory transduction_Homo sapiens_hsa04740	1.26195134
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.25443630
38	Serotonergic synapse_Homo sapiens_hsa04726	1.22283727
39	Circadian entrainment_Homo sapiens_hsa04713	1.20479050
40	Alzheimers disease_Homo sapiens_hsa05010	1.17594253
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12340820
42	Propanoate metabolism_Homo sapiens_hsa00640	1.10087132
43	Ribosome_Homo sapiens_hsa03010	1.08079483
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.07383764
45	Cocaine addiction_Homo sapiens_hsa05030	1.07299493
46	Regulation of autophagy_Homo sapiens_hsa04140	1.06094153
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00462223
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.99576689
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98539594
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97821017
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.95729940
52	Peroxisome_Homo sapiens_hsa04146	0.92128333
53	Circadian rhythm_Homo sapiens_hsa04710	0.91569540
54	One carbon pool by folate_Homo sapiens_hsa00670	0.90877818
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.89760135
56	ABC transporters_Homo sapiens_hsa02010	0.88630369
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87353017
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83654376
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.80545678
60	Cholinergic synapse_Homo sapiens_hsa04725	0.75951399
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75632184
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74365731
63	Basal cell carcinoma_Homo sapiens_hsa05217	0.73321968
64	Retinol metabolism_Homo sapiens_hsa00830	0.71387190
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69648353
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.67511506
67	Sulfur metabolism_Homo sapiens_hsa00920	0.67385459
68	Purine metabolism_Homo sapiens_hsa00230	0.66382411
69	Amphetamine addiction_Homo sapiens_hsa05031	0.63989567
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.63118558
71	Long-term depression_Homo sapiens_hsa04730	0.62658337
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59397087
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.59095947
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58637386
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58091202
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.57967456
77	Salivary secretion_Homo sapiens_hsa04970	0.54626807
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51705407
79	Metabolic pathways_Homo sapiens_hsa01100	0.47340609
80	Axon guidance_Homo sapiens_hsa04360	0.46728843
81	Sulfur relay system_Homo sapiens_hsa04122	0.45648845
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45201262
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44732296
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43949151
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43103195
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.42862254
87	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42654293
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42158102
89	Mineral absorption_Homo sapiens_hsa04978	0.38945452
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38360144
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38223132
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.38213319
93	Alcoholism_Homo sapiens_hsa05034	0.37148638
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36157981
95	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.34700962
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.32687532
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.32131445
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30513833
99	Primary immunodeficiency_Homo sapiens_hsa05340	0.29657200
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28337417

ZNF419

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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