ZNF420

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.22912269
2single strand break repair (GO:0000012)3.69657154
3neuron cell-cell adhesion (GO:0007158)3.61295489
4presynaptic membrane assembly (GO:0097105)3.52860397
5pyrimidine nucleobase catabolic process (GO:0006208)3.49445816
6neural tube formation (GO:0001841)3.45677365
7centriole replication (GO:0007099)3.41286017
8somatic hypermutation of immunoglobulin genes (GO:0016446)3.35497063
9somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35497063
10cullin deneddylation (GO:0010388)3.23198767
11histone H2A acetylation (GO:0043968)3.19691397
12intraciliary transport (GO:0042073)3.18375573
13DNA double-strand break processing (GO:0000729)3.15243239
14DNA damage response, detection of DNA damage (GO:0042769)3.08330393
15limb bud formation (GO:0060174)3.03249364
16retinal ganglion cell axon guidance (GO:0031290)3.03215397
17protein polyglutamylation (GO:0018095)3.02956979
18piRNA metabolic process (GO:0034587)2.99147929
19microtubule depolymerization (GO:0007019)2.95146084
20presynaptic membrane organization (GO:0097090)2.94506779
21protein deneddylation (GO:0000338)2.87425602
22replication fork processing (GO:0031297)2.86445716
23negative regulation of translation, ncRNA-mediated (GO:0040033)2.85447883
24regulation of translation, ncRNA-mediated (GO:0045974)2.85447883
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.85447883
26histone mRNA catabolic process (GO:0071044)2.84535843
27histone mRNA metabolic process (GO:0008334)2.83558098
28nonmotile primary cilium assembly (GO:0035058)2.83161434
29lactate metabolic process (GO:0006089)2.81759498
30regulation of timing of cell differentiation (GO:0048505)2.79365615
31inositol phosphate catabolic process (GO:0071545)2.79105675
32resolution of meiotic recombination intermediates (GO:0000712)2.78532564
33microtubule polymerization or depolymerization (GO:0031109)2.77753194
34regulation of DNA endoreduplication (GO:0032875)2.74974357
35regulation of development, heterochronic (GO:0040034)2.74611812
36water-soluble vitamin biosynthetic process (GO:0042364)2.73673467
37negative regulation of DNA recombination (GO:0045910)2.73589281
38microtubule anchoring (GO:0034453)2.73046515
39DNA integration (GO:0015074)2.72880635
40epithelial cilium movement (GO:0003351)2.71295948
41protein-cofactor linkage (GO:0018065)2.70087782
42regulation of telomere maintenance (GO:0032204)2.68490838
43otic vesicle formation (GO:0030916)2.68350651
44negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.68183122
45axoneme assembly (GO:0035082)2.67656159
46cilium organization (GO:0044782)2.67294494
47nucleobase catabolic process (GO:0046113)2.67196878
48behavioral response to nicotine (GO:0035095)2.67143889
49organelle disassembly (GO:1903008)2.66750222
50ncRNA catabolic process (GO:0034661)2.66720362
51acrosome reaction (GO:0007340)2.66348218
52cilium assembly (GO:0042384)2.66087159
53negative regulation of DNA-dependent DNA replication (GO:2000104)2.63111516
54regulation of helicase activity (GO:0051095)2.57169686
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56227806
56regulation of sarcomere organization (GO:0060297)2.55944279
57regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.55788340
58aldehyde catabolic process (GO:0046185)2.53763370
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52451554
60double-strand break repair via nonhomologous end joining (GO:0006303)2.52343732
61non-recombinational repair (GO:0000726)2.52343732
62protein K11-linked deubiquitination (GO:0035871)2.51955820
63regulation of meiosis I (GO:0060631)2.51508893
64negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.48865025
65behavioral response to ethanol (GO:0048149)2.48421696
66chromatin remodeling at centromere (GO:0031055)2.47700683
67negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47599052
68protein localization to cilium (GO:0061512)2.47222558
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46775073
70regulation of hexokinase activity (GO:1903299)2.46210944
71regulation of glucokinase activity (GO:0033131)2.46210944
72platelet dense granule organization (GO:0060155)2.44141051
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43509449
74cilium morphogenesis (GO:0060271)2.42188204
75anterograde synaptic vesicle transport (GO:0048490)2.40980896
76positive regulation of oligodendrocyte differentiation (GO:0048714)2.39990526
77somite development (GO:0061053)2.39221900
78olfactory bulb development (GO:0021772)2.37503066
79synapsis (GO:0007129)2.36096486
80protein localization to synapse (GO:0035418)2.35589824
81positive regulation of mitochondrial fission (GO:0090141)2.33051296
82postreplication repair (GO:0006301)2.33013093
83protein neddylation (GO:0045116)2.31202245
84sympathetic nervous system development (GO:0048485)2.29295949
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.29180910
86isotype switching (GO:0045190)2.29180910
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.29180910
88mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.28557968
89positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.28557968
90establishment of protein localization to mitochondrial membrane (GO:0090151)2.28153287
91DNA methylation involved in gamete generation (GO:0043046)2.27865642
92keratinocyte development (GO:0003334)2.26497930
93atrial cardiac muscle cell action potential (GO:0086014)2.26049445
94photoreceptor cell maintenance (GO:0045494)2.25530048
95polyol catabolic process (GO:0046174)2.25504315
96cilium movement (GO:0003341)2.24102941
97translesion synthesis (GO:0019985)2.24032688
98regulation of collateral sprouting (GO:0048670)2.23515644
99centriole assembly (GO:0098534)2.23442709
100cardiac right ventricle morphogenesis (GO:0003215)2.23017381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.49586884
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.49341935
3IGF1R_20145208_ChIP-Seq_DFB_Human3.23621029
4GBX2_23144817_ChIP-Seq_PC3_Human2.90581934
5FUS_26573619_Chip-Seq_HEK293_Human2.80445765
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75556946
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69822394
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55320182
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50136208
10EWS_26573619_Chip-Seq_HEK293_Human2.40376385
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31195954
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29823041
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27234958
14TAF15_26573619_Chip-Seq_HEK293_Human2.25984876
15EZH2_22144423_ChIP-Seq_EOC_Human2.25592575
16* EST1_17652178_ChIP-ChIP_JURKAT_Human2.23425297
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21774166
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.19111039
19P300_19829295_ChIP-Seq_ESCs_Human2.11515414
20VDR_22108803_ChIP-Seq_LS180_Human2.10047102
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01409282
22* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99510297
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87258830
24ELK1_19687146_ChIP-ChIP_HELA_Human1.81511464
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.78288048
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74989962
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71545635
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69806382
29* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65896000
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63785699
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61899223
32SMAD4_21799915_ChIP-Seq_A2780_Human1.58778035
33ER_23166858_ChIP-Seq_MCF-7_Human1.55958412
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53644082
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.52633782
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52141399
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.51830304
38RNF2_27304074_Chip-Seq_NSC_Mouse1.49734936
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47724471
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47087700
41IRF1_19129219_ChIP-ChIP_H3396_Human1.47014403
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46654331
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45365049
44CBP_20019798_ChIP-Seq_JUKART_Human1.45365049
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.44262477
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43320763
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43168880
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42966946
49STAT3_23295773_ChIP-Seq_U87_Human1.40260825
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38745040
51MYC_18940864_ChIP-ChIP_HL60_Human1.38255021
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.37493921
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35278643
54VDR_23849224_ChIP-Seq_CD4+_Human1.33975961
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33503992
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.32734145
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31213930
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29259599
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27739963
60* ETS1_20019798_ChIP-Seq_JURKAT_Human1.26755347
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.26602965
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26445041
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26142760
64AR_25329375_ChIP-Seq_VCAP_Human1.25473141
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20080597
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20080597
67TCF4_23295773_ChIP-Seq_U87_Human1.20065536
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.17390622
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17062596
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15052142
71* RUNX2_22187159_ChIP-Seq_PCA_Human1.13299884
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12663096
73TP53_22573176_ChIP-Seq_HFKS_Human1.12071858
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10924899
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10645170
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.10285212
77SOX2_19829295_ChIP-Seq_ESCs_Human1.10185428
78NANOG_19829295_ChIP-Seq_ESCs_Human1.10185428
79FOXP3_21729870_ChIP-Seq_TREG_Human1.09927916
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09785333
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.09433729
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08759052
83BCAT_22108803_ChIP-Seq_LS180_Human1.08322065
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08140772
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07951820
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.07606035
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.07228450
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06543365
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05675275
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03413859
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02563472
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01581667
93TCF4_22108803_ChIP-Seq_LS180_Human1.01241998
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00967184
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99817737
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99255912
97HTT_18923047_ChIP-ChIP_STHdh_Human0.98262415
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98098508
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97783033
100P53_22387025_ChIP-Seq_ESCs_Mouse0.97108000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.35747954
2MP0003880_abnormal_central_pattern3.32302090
3MP0002102_abnormal_ear_morphology3.18115116
4MP0008877_abnormal_DNA_methylation2.91825490
5MP0006072_abnormal_retinal_apoptosis2.46223821
6MP0008058_abnormal_DNA_repair2.40768220
7MP0003787_abnormal_imprinting2.36976579
8MP0003890_abnormal_embryonic-extraembry2.26585062
9MP0006292_abnormal_olfactory_placode2.14591064
10MP0002736_abnormal_nociception_after2.00788746
11MP0003121_genomic_imprinting1.93322490
12MP0003567_abnormal_fetal_cardiomyocyte1.88089190
13MP0002234_abnormal_pharynx_morphology1.86575868
14MP0000516_abnormal_urinary_system1.80391845
15MP0005367_renal/urinary_system_phenotyp1.80391845
16MP0001529_abnormal_vocalization1.78457753
17MP0006276_abnormal_autonomic_nervous1.78396698
18MP0008057_abnormal_DNA_replication1.78265798
19MP0002751_abnormal_autonomic_nervous1.73349367
20MP0001984_abnormal_olfaction1.68972749
21MP0002938_white_spotting1.68056082
22MP0005551_abnormal_eye_electrophysiolog1.66461660
23MP0003718_maternal_effect1.64047052
24MP0001485_abnormal_pinna_reflex1.58367703
25MP0000778_abnormal_nervous_system1.57916040
26MP0000631_abnormal_neuroendocrine_gland1.57348778
27MP0009046_muscle_twitch1.55551655
28MP0001486_abnormal_startle_reflex1.55153483
29MP0010094_abnormal_chromosome_stability1.54666785
30MP0005423_abnormal_somatic_nervous1.54219706
31MP0003122_maternal_imprinting1.54030873
32MP0002638_abnormal_pupillary_reflex1.53236265
33MP0005253_abnormal_eye_physiology1.51906783
34MP0001293_anophthalmia1.47160802
35MP0001968_abnormal_touch/_nociception1.47061217
36MP0008789_abnormal_olfactory_epithelium1.45833604
37MP0002822_catalepsy1.43807118
38MP0004133_heterotaxia1.42769008
39MP0002272_abnormal_nervous_system1.37790758
40MP0002735_abnormal_chemical_nociception1.32582834
41MP0008872_abnormal_physiological_respon1.30541939
42MP0008995_early_reproductive_senescence1.29790192
43MP0005386_behavior/neurological_phenoty1.29762506
44MP0004924_abnormal_behavior1.29762506
45MP0004142_abnormal_muscle_tone1.27520442
46MP0002233_abnormal_nose_morphology1.25795015
47MP0005499_abnormal_olfactory_system1.25345107
48MP0005394_taste/olfaction_phenotype1.25345107
49MP0003136_yellow_coat_color1.20817018
50MP0005187_abnormal_penis_morphology1.20353658
51MP0009745_abnormal_behavioral_response1.19361405
52MP0005075_abnormal_melanosome_morpholog1.15965151
53MP0002282_abnormal_trachea_morphology1.13759472
54MP0005084_abnormal_gallbladder_morpholo1.13454131
55MP0004742_abnormal_vestibular_system1.12502365
56MP0002557_abnormal_social/conspecific_i1.09731804
57MP0001188_hyperpigmentation1.09580868
58MP0005645_abnormal_hypothalamus_physiol1.09200511
59MP0001986_abnormal_taste_sensitivity1.08931861
60MP0003693_abnormal_embryo_hatching1.08113007
61MP0004885_abnormal_endolymph1.07892039
62MP0000427_abnormal_hair_cycle1.07464669
63MP0004859_abnormal_synaptic_plasticity1.06103640
64MP0002067_abnormal_sensory_capabilities1.04642566
65MP0004215_abnormal_myocardial_fiber1.03457623
66MP0003635_abnormal_synaptic_transmissio1.03286318
67MP0005391_vision/eye_phenotype1.03205562
68MP0003937_abnormal_limbs/digits/tail_de1.02934293
69MP0000647_abnormal_sebaceous_gland1.02297700
70MP0002572_abnormal_emotion/affect_behav1.01003134
71MP0002734_abnormal_mechanical_nocicepti1.00418709
72MP0002210_abnormal_sex_determination0.99140997
73MP0001929_abnormal_gametogenesis0.98274921
74MP0003221_abnormal_cardiomyocyte_apopto0.98176567
75MP0000955_abnormal_spinal_cord0.97744283
76MP0005646_abnormal_pituitary_gland0.97704768
77MP0000372_irregular_coat_pigmentation0.97700959
78MP0002160_abnormal_reproductive_system0.96386023
79MP0001286_abnormal_eye_development0.96231515
80MP0002090_abnormal_vision0.95642018
81MP0002095_abnormal_skin_pigmentation0.95480793
82MP0002752_abnormal_somatic_nervous0.95229275
83MP0001324_abnormal_eye_pigmentation0.93943686
84MP0002184_abnormal_innervation0.93877492
85MP0000653_abnormal_sex_gland0.93183321
86MP0004270_analgesia0.92937512
87MP0003119_abnormal_digestive_system0.92882804
88MP0003861_abnormal_nervous_system0.92626113
89MP0003698_abnormal_male_reproductive0.92505884
90MP0004811_abnormal_neuron_physiology0.91608414
91MP0004145_abnormal_muscle_electrophysio0.91413558
92MP0002882_abnormal_neuron_morphology0.89096347
93MP0001145_abnormal_male_reproductive0.88653349
94MP0002063_abnormal_learning/memory/cond0.88604599
95MP0002837_dystrophic_cardiac_calcinosis0.86859985
96MP0005195_abnormal_posterior_eye0.86346013
97MP0003315_abnormal_perineum_morphology0.84959363
98MP0008932_abnormal_embryonic_tissue0.83665526
99MP0000049_abnormal_middle_ear0.83478699
100MP0003786_premature_aging0.82191536

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.72022753
2Pancreatic cysts (HP:0001737)3.42821834
3Nephrogenic diabetes insipidus (HP:0009806)3.39992440
4Pancreatic fibrosis (HP:0100732)3.33863374
5Medial flaring of the eyebrow (HP:0010747)3.21922947
6Abnormality of the labia minora (HP:0012880)3.19311398
7Gait imbalance (HP:0002141)3.14866652
8Congenital primary aphakia (HP:0007707)3.06363623
9Septo-optic dysplasia (HP:0100842)3.01831346
10Abnormality of midbrain morphology (HP:0002418)2.96327113
11Molar tooth sign on MRI (HP:0002419)2.96327113
12Hyperventilation (HP:0002883)2.87580199
13Focal motor seizures (HP:0011153)2.80593217
14Genital tract atresia (HP:0001827)2.78108011
15Vaginal atresia (HP:0000148)2.77962383
16Nephronophthisis (HP:0000090)2.76993633
17Hip dysplasia (HP:0001385)2.75560839
18Volvulus (HP:0002580)2.74953299
19Colon cancer (HP:0003003)2.73982285
20Ependymoma (HP:0002888)2.73161194
21Intestinal atresia (HP:0011100)2.67814414
22Lissencephaly (HP:0001339)2.55401810
23Optic nerve hypoplasia (HP:0000609)2.55004019
24Astrocytoma (HP:0009592)2.43776977
25Abnormality of the astrocytes (HP:0100707)2.43776977
26Renal cortical cysts (HP:0000803)2.43574339
27Abnormality of the renal medulla (HP:0100957)2.41847589
28Methylmalonic acidemia (HP:0002912)2.35507701
29Chronic hepatic failure (HP:0100626)2.33994500
30Limb dystonia (HP:0002451)2.32836828
31Increased hepatocellular lipid droplets (HP:0006565)2.32461088
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29464188
33Hyperglycinemia (HP:0002154)2.29212229
34Poor coordination (HP:0002370)2.25133332
35Abnormality of the renal cortex (HP:0011035)2.22878076
36Glioma (HP:0009733)2.19997583
37Sclerocornea (HP:0000647)2.17938471
38Broad-based gait (HP:0002136)2.14789643
39Small hand (HP:0200055)2.12130523
40Anencephaly (HP:0002323)2.10567025
41Drooling (HP:0002307)2.10318687
42Lipid accumulation in hepatocytes (HP:0006561)2.09897542
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.09885289
44Hepatoblastoma (HP:0002884)2.09370143
45Cystic liver disease (HP:0006706)2.06267530
46Tubulointerstitial nephritis (HP:0001970)2.05968364
47Carpal bone hypoplasia (HP:0001498)1.96653756
48Absent septum pellucidum (HP:0001331)1.94742835
49Methylmalonic aciduria (HP:0012120)1.94373557
50Abnormality of the septum pellucidum (HP:0007375)1.94050542
51Male pseudohermaphroditism (HP:0000037)1.93125995
52Abolished electroretinogram (ERG) (HP:0000550)1.92065543
53Postaxial hand polydactyly (HP:0001162)1.91610982
54Bifid tongue (HP:0010297)1.91137474
55Broad foot (HP:0001769)1.91047692
56Narrow forehead (HP:0000341)1.89318146
57Decreased testicular size (HP:0008734)1.88203047
58Specific learning disability (HP:0001328)1.87187580
59Excessive salivation (HP:0003781)1.86012919
60Sloping forehead (HP:0000340)1.85262201
61Inability to walk (HP:0002540)1.85192738
62Preaxial hand polydactyly (HP:0001177)1.84376610
63Aplasia/Hypoplasia of the sternum (HP:0006714)1.83191814
64Progressive inability to walk (HP:0002505)1.82596486
65Long clavicles (HP:0000890)1.81877974
66Growth hormone deficiency (HP:0000824)1.81583571
67Postaxial foot polydactyly (HP:0001830)1.80090850
68Thyroid-stimulating hormone excess (HP:0002925)1.80090018
69Occipital encephalocele (HP:0002085)1.79179484
70Supernumerary spleens (HP:0009799)1.78904882
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.78429106
72Gonadotropin excess (HP:0000837)1.76782951
73Short foot (HP:0001773)1.76696536
74Abnormality of the middle phalanges of the toes (HP:0010183)1.76222952
75Abnormality of chromosome stability (HP:0003220)1.76044180
76Fetal akinesia sequence (HP:0001989)1.75079483
77Abnormal lung lobation (HP:0002101)1.74858861
78Pendular nystagmus (HP:0012043)1.74294900
79Micropenis (HP:0000054)1.73625818
80Abnormality of glycine metabolism (HP:0010895)1.69857633
81Abnormality of serine family amino acid metabolism (HP:0010894)1.69857633
82Short tibia (HP:0005736)1.68663441
83Oligodactyly (hands) (HP:0001180)1.68062543
84Dandy-Walker malformation (HP:0001305)1.67521967
85Gastrointestinal atresia (HP:0002589)1.67240246
86Pachygyria (HP:0001302)1.67218637
87Aqueductal stenosis (HP:0002410)1.67073824
88Disproportionate short-trunk short stature (HP:0003521)1.66158717
89Focal seizures (HP:0007359)1.63686676
90Type II lissencephaly (HP:0007260)1.63655495
91Congenital hepatic fibrosis (HP:0002612)1.61882273
92Astigmatism (HP:0000483)1.61610923
93Abnormality of macular pigmentation (HP:0008002)1.61214303
94Gaze-evoked nystagmus (HP:0000640)1.60951868
95Abnormal biliary tract physiology (HP:0012439)1.60100705
96Bile duct proliferation (HP:0001408)1.60100705
97Cerebellar dysplasia (HP:0007033)1.59402366
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.59220915
99Multicystic kidney dysplasia (HP:0000003)1.59195387
100Oculomotor apraxia (HP:0000657)1.58274498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.03019997
2MARK13.03992175
3WNK32.97248213
4CASK2.95264498
5PNCK2.68455738
6FRK2.60830484
7SRPK12.31843013
8BMPR1B2.05654804
9MAPK132.03049146
10TNIK2.02013157
11TRIM281.99796412
12NUAK11.96957981
13BCR1.85453290
14MAP3K41.81410791
15CAMKK21.64539685
16EIF2AK31.58842885
17BRD41.58639246
18ACVR1B1.53446645
19STK38L1.50026327
20INSRR1.49199847
21OXSR11.44667051
22PLK31.41079731
23BRSK21.40965018
24ZAK1.36088028
25EPHA41.28624687
26DYRK31.28591432
27CSNK1G11.28398031
28TSSK61.23349773
29PINK11.21816910
30VRK11.21168631
31MKNK21.20924301
32CSNK1G21.19751695
33PLK41.17923629
34PLK21.09728436
35MINK11.09027060
36CDK191.08205092
37MKNK11.07160911
38MAP2K71.04978831
39CDC71.03072117
40STK161.02772589
41CSNK1G31.00857434
42ADRBK21.00793423
43GRK10.97339434
44TAOK30.97284015
45CDK30.97216057
46ERBB30.96396769
47FLT30.94159142
48WEE10.92300328
49NLK0.89329102
50RPS6KA40.88947653
51DYRK20.88671655
52STK390.87216520
53PAK30.87092975
54TGFBR10.86559828
55NTRK30.83528208
56PBK0.81992367
57BCKDK0.80032633
58NEK10.79305347
59CSNK1A1L0.78256008
60TTK0.76866449
61FGFR20.76392231
62PRKCE0.74023067
63EIF2AK20.68313557
64BUB10.66475941
65* ATM0.66290239
66PLK10.65573619
67MAP2K40.62738629
68UHMK10.58282458
69ATR0.58209011
70STK30.58180203
71ERBB40.56547014
72OBSCN0.55058740
73MAP2K60.54909902
74GRK70.54204922
75STK240.53724663
76PRKCG0.53372390
77DYRK1A0.52451682
78PKN20.52090718
79CAMK1G0.51158734
80CAMK40.47514021
81NTRK20.47025911
82CAMK2A0.45964340
83PKN10.44520008
84CSNK1E0.42989871
85WNK40.41521193
86YES10.39301143
87FGFR10.38864386
88LATS10.38640313
89RPS6KA50.38512034
90CHEK20.38124196
91CSNK1A10.37787688
92PRKACB0.37773345
93PIK3CA0.35436669
94CAMK2B0.34814946
95ADRBK10.34724533
96CSNK1D0.33477485
97PASK0.32078476
98PRKDC0.31872734
99CDK50.31683398
100CAMK10.31309249

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.12738628
2Protein export_Homo sapiens_hsa030602.80144049
3Basal transcription factors_Homo sapiens_hsa030222.61491884
4Nicotine addiction_Homo sapiens_hsa050332.44900982
5RNA degradation_Homo sapiens_hsa030182.36756949
6Fanconi anemia pathway_Homo sapiens_hsa034602.32073864
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31585689
8Propanoate metabolism_Homo sapiens_hsa006402.25707977
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25320008
10Phototransduction_Homo sapiens_hsa047442.22354415
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18981478
12Mismatch repair_Homo sapiens_hsa034302.09442845
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09298844
14Homologous recombination_Homo sapiens_hsa034402.03278258
15RNA polymerase_Homo sapiens_hsa030202.02359885
16Butanoate metabolism_Homo sapiens_hsa006501.94248963
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93275349
18Parkinsons disease_Homo sapiens_hsa050121.81606433
19Oxidative phosphorylation_Homo sapiens_hsa001901.71008298
20RNA transport_Homo sapiens_hsa030131.70221484
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61097283
22Spliceosome_Homo sapiens_hsa030401.55013124
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53050603
24Circadian rhythm_Homo sapiens_hsa047101.52938345
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.48435498
26Nucleotide excision repair_Homo sapiens_hsa034201.42891454
27Base excision repair_Homo sapiens_hsa034101.42348186
28Regulation of autophagy_Homo sapiens_hsa041401.41228272
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38129466
30Peroxisome_Homo sapiens_hsa041461.37768301
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33011594
32One carbon pool by folate_Homo sapiens_hsa006701.31519864
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.31255791
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30908043
35Proteasome_Homo sapiens_hsa030501.25834637
36Huntingtons disease_Homo sapiens_hsa050161.25045206
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21565876
38Taste transduction_Homo sapiens_hsa047421.21482701
39Selenocompound metabolism_Homo sapiens_hsa004501.20652112
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20527631
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12940182
42Steroid biosynthesis_Homo sapiens_hsa001001.11724276
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11171704
44Cell cycle_Homo sapiens_hsa041101.10355626
45Ether lipid metabolism_Homo sapiens_hsa005651.08440146
46Linoleic acid metabolism_Homo sapiens_hsa005911.06590680
47DNA replication_Homo sapiens_hsa030301.03195046
48Olfactory transduction_Homo sapiens_hsa047400.95656421
49Purine metabolism_Homo sapiens_hsa002300.93741795
50Tryptophan metabolism_Homo sapiens_hsa003800.92946039
51Nitrogen metabolism_Homo sapiens_hsa009100.92591863
52GABAergic synapse_Homo sapiens_hsa047270.90775587
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90536191
54Hedgehog signaling pathway_Homo sapiens_hsa043400.90202427
55Oocyte meiosis_Homo sapiens_hsa041140.86573651
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84138460
57Cocaine addiction_Homo sapiens_hsa050300.82392000
58mRNA surveillance pathway_Homo sapiens_hsa030150.81813899
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81184515
60Amphetamine addiction_Homo sapiens_hsa050310.81086278
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80105544
62Cardiac muscle contraction_Homo sapiens_hsa042600.75111093
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74597139
64Glutamatergic synapse_Homo sapiens_hsa047240.73158416
65Morphine addiction_Homo sapiens_hsa050320.72152486
66Dopaminergic synapse_Homo sapiens_hsa047280.71660872
67Alzheimers disease_Homo sapiens_hsa050100.70053605
68Pyrimidine metabolism_Homo sapiens_hsa002400.69600854
69TGF-beta signaling pathway_Homo sapiens_hsa043500.68585023
70Fatty acid elongation_Homo sapiens_hsa000620.65740989
71Serotonergic synapse_Homo sapiens_hsa047260.64453026
72Folate biosynthesis_Homo sapiens_hsa007900.63914931
73Metabolic pathways_Homo sapiens_hsa011000.62983687
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62317764
75Circadian entrainment_Homo sapiens_hsa047130.61830025
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.61207125
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56507846
78Fatty acid degradation_Homo sapiens_hsa000710.55036943
79Pyruvate metabolism_Homo sapiens_hsa006200.53802177
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.53240277
81Lysine degradation_Homo sapiens_hsa003100.48563279
82Axon guidance_Homo sapiens_hsa043600.47785252
83Long-term depression_Homo sapiens_hsa047300.47250793
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47227052
85Retinol metabolism_Homo sapiens_hsa008300.46125135
86Alcoholism_Homo sapiens_hsa050340.46040916
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45828805
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45555160
89Chemical carcinogenesis_Homo sapiens_hsa052040.45441144
90Dorso-ventral axis formation_Homo sapiens_hsa043200.43152813
91Caffeine metabolism_Homo sapiens_hsa002320.43113094
92beta-Alanine metabolism_Homo sapiens_hsa004100.42506433
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40440435
94Fatty acid metabolism_Homo sapiens_hsa012120.38550663
95Carbon metabolism_Homo sapiens_hsa012000.37419499
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37168391
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36304164
98Insulin secretion_Homo sapiens_hsa049110.35638548
99Collecting duct acid secretion_Homo sapiens_hsa049660.34578457
100p53 signaling pathway_Homo sapiens_hsa041150.32535138

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