ZNF423

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.93115650
2presynaptic membrane assembly (GO:0097105)4.46234803
3postsynaptic membrane organization (GO:0001941)4.31941408
4presynaptic membrane organization (GO:0097090)4.26547176
5paraxial mesoderm development (GO:0048339)4.03880078
6lateral sprouting from an epithelium (GO:0060601)3.81335255
7axon extension involved in axon guidance (GO:0048846)3.74264412
8neuron projection extension involved in neuron projection guidance (GO:1902284)3.74264412
9nucleobase catabolic process (GO:0046113)3.64224450
10vocalization behavior (GO:0071625)3.57141907
11neuron cell-cell adhesion (GO:0007158)3.50440344
12neuron recognition (GO:0008038)3.47805461
13spinal cord development (GO:0021510)3.41058224
14axonal fasciculation (GO:0007413)3.40097026
15cell migration in hindbrain (GO:0021535)3.15120517
16convergent extension (GO:0060026)3.14320881
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13696336
18outer ear morphogenesis (GO:0042473)3.06054039
19retinal ganglion cell axon guidance (GO:0031290)2.99737732
20regulation of gene silencing by RNA (GO:0060966)2.96611075
21regulation of posttranscriptional gene silencing (GO:0060147)2.96611075
22regulation of gene silencing by miRNA (GO:0060964)2.96611075
23lung-associated mesenchyme development (GO:0060484)2.92857604
24limb bud formation (GO:0060174)2.92626822
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90156996
26somite development (GO:0061053)2.88673227
27generation of neurons (GO:0048699)2.86796526
28G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.85311740
29establishment of mitochondrion localization (GO:0051654)2.83519821
30otic vesicle formation (GO:0030916)2.82366287
31central nervous system projection neuron axonogenesis (GO:0021952)2.78757098
32establishment of nucleus localization (GO:0040023)2.77012332
33protein localization to synapse (GO:0035418)2.76871482
34dendritic spine morphogenesis (GO:0060997)2.74856654
35auditory behavior (GO:0031223)2.72108675
36axon extension (GO:0048675)2.71328201
37pre-miRNA processing (GO:0031054)2.68390197
38notochord development (GO:0030903)2.64665546
39thalamus development (GO:0021794)2.63460094
40midbrain development (GO:0030901)2.61124718
41apical protein localization (GO:0045176)2.60772201
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60589483
43negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60225538
44negative regulation of translation, ncRNA-mediated (GO:0040033)2.60225538
45regulation of translation, ncRNA-mediated (GO:0045974)2.60225538
46neuronal stem cell maintenance (GO:0097150)2.59232592
47camera-type eye morphogenesis (GO:0048593)2.58105490
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57748989
49negative regulation of axon guidance (GO:1902668)2.56605052
50cerebral cortex radially oriented cell migration (GO:0021799)2.55871125
51regulation of axon guidance (GO:1902667)2.52261656
52transmission of nerve impulse (GO:0019226)2.50641205
53mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.50164757
54regulation of non-canonical Wnt signaling pathway (GO:2000050)2.49841491
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.49441334
56positive regulation of synapse assembly (GO:0051965)2.47288530
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43689506
58mitochondrion transport along microtubule (GO:0047497)2.43689506
59myelination in peripheral nervous system (GO:0022011)2.42547803
60peripheral nervous system axon ensheathment (GO:0032292)2.42547803
61forebrain neuron differentiation (GO:0021879)2.42546674
62neurotransmitter-gated ion channel clustering (GO:0072578)2.42355062
63regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.41562511
64mesenchymal to epithelial transition (GO:0060231)2.39524362
65dendrite morphogenesis (GO:0048813)2.36712669
66kidney morphogenesis (GO:0060993)2.36531755
67calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.36365409
68cell proliferation in forebrain (GO:0021846)2.36197033
69neuronal ion channel clustering (GO:0045161)2.36183653
70regulation of cell fate specification (GO:0042659)2.36073862
71olfactory bulb development (GO:0021772)2.34982682
72post-anal tail morphogenesis (GO:0036342)2.34106578
73establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.33983336
74nonmotile primary cilium assembly (GO:0035058)2.33300354
75non-canonical Wnt signaling pathway (GO:0035567)2.32880991
76mechanosensory behavior (GO:0007638)2.32687172
77cell surface receptor signaling pathway involved in heart development (GO:0061311)2.32484175
78Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32146219
79appendage development (GO:0048736)2.31755528
80limb development (GO:0060173)2.31755528
81hindbrain development (GO:0030902)2.31683800
82regulation of development, heterochronic (GO:0040034)2.31640673
83cranial nerve development (GO:0021545)2.31396183
84ionotropic glutamate receptor signaling pathway (GO:0035235)2.30827985
85synapse assembly (GO:0007416)2.30055234
86dorsal/ventral axis specification (GO:0009950)2.28829205
87regulation of axon extension involved in axon guidance (GO:0048841)2.28398193
88innervation (GO:0060384)2.24358695
89negative chemotaxis (GO:0050919)2.23356863
90sarcoplasmic reticulum calcium ion transport (GO:0070296)2.21963067
91neuron migration (GO:0001764)2.21699259
92heterochromatin organization (GO:0070828)2.21544206
93regulation of establishment of planar polarity (GO:0090175)2.21363583
94exploration behavior (GO:0035640)2.21350152
95neuronal action potential propagation (GO:0019227)2.20726593
96short-term memory (GO:0007614)2.20419752
97neuron projection extension (GO:1990138)2.19177531
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.17797813
99regulation of timing of cell differentiation (GO:0048505)2.17778568
100protein-DNA complex disassembly (GO:0032986)2.17150830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59127451
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.69675546
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.24019898
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.00011995
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53711859
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.52541972
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44550089
8POU5F1_16153702_ChIP-ChIP_HESCs_Human2.26183321
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.20381897
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17384930
11GBX2_23144817_ChIP-Seq_PC3_Human2.12121646
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.10942202
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08286541
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03492201
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03492201
16RNF2_27304074_Chip-Seq_ESCs_Mouse1.93970920
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90434520
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.84448034
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83067034
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81895178
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76456695
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76081168
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74480093
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74469653
25SOX2_16153702_ChIP-ChIP_HESCs_Human1.73532582
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71218182
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71218182
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71218182
29RNF2_27304074_Chip-Seq_NSC_Mouse1.69595220
30REST_21632747_ChIP-Seq_MESCs_Mouse1.66512723
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.64003095
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.63351817
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62382798
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57735364
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57735364
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57417937
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55232826
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53435661
39IGF1R_20145208_ChIP-Seq_DFB_Human1.53306719
40TAF15_26573619_Chip-Seq_HEK293_Human1.52645465
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51680026
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51492263
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51067663
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.50570555
45FUS_26573619_Chip-Seq_HEK293_Human1.48126852
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46802139
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.45779817
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44334667
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.42669613
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.40823625
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38447226
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.37546906
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37394499
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36382049
55POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.34166710
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34098556
57* P300_19829295_ChIP-Seq_ESCs_Human1.31465627
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29312813
59* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28942639
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28610285
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.25637984
62OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25589913
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.25337112
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25263007
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24483780
66TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24245245
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23122420
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22692476
69DROSHA_22980978_ChIP-Seq_HELA_Human1.20531506
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.19850586
71TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18696514
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18541018
73VDR_22108803_ChIP-Seq_LS180_Human1.18059038
74TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18006715
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.17439045
76SOX9_26525672_Chip-Seq_HEART_Mouse1.17416923
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17385531
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16699413
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16643733
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15547244
81AR_21572438_ChIP-Seq_LNCaP_Human1.14070200
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13768386
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12660424
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12638659
85* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12632599
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12210525
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08622610
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07888364
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05906960
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04720066
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03679765
92EWS_26573619_Chip-Seq_HEK293_Human1.03295516
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03195876
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03114728
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02412017
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.01352991
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00951758
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00493652
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99964042
100ZNF274_21170338_ChIP-Seq_K562_Hela0.99671948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology2.93718428
2MP0000778_abnormal_nervous_system2.63246587
3MP0003122_maternal_imprinting2.44687023
4MP0004859_abnormal_synaptic_plasticity2.40460165
5MP0000566_synostosis2.40404620
6MP0003880_abnormal_central_pattern2.33253371
7MP0006292_abnormal_olfactory_placode2.30735265
8MP0004270_analgesia2.03794598
9MP0005423_abnormal_somatic_nervous1.94836310
10MP0003136_yellow_coat_color1.93506985
11MP0000049_abnormal_middle_ear1.89342629
12MP0001293_anophthalmia1.82352824
13MP0002653_abnormal_ependyma_morphology1.81793224
14MP0003890_abnormal_embryonic-extraembry1.71935583
15MP0003121_genomic_imprinting1.71267237
16MP0001299_abnormal_eye_distance/1.66648524
17MP0003937_abnormal_limbs/digits/tail_de1.65916850
18MP0003119_abnormal_digestive_system1.65575095
19MP0001529_abnormal_vocalization1.62271773
20MP0002822_catalepsy1.61569255
21MP0004133_heterotaxia1.61065850
22MP0000751_myopathy1.59490944
23MP0001984_abnormal_olfaction1.59395363
24MP0002938_white_spotting1.56821654
25MP0003938_abnormal_ear_development1.54052328
26MP0000631_abnormal_neuroendocrine_gland1.51512525
27MP0002697_abnormal_eye_size1.50979119
28MP0003635_abnormal_synaptic_transmissio1.50718001
29MP0000955_abnormal_spinal_cord1.49931634
30MP0003861_abnormal_nervous_system1.49716431
31MP0000537_abnormal_urethra_morphology1.49678558
32MP0004885_abnormal_endolymph1.48979208
33MP0006276_abnormal_autonomic_nervous1.46339460
34MP0002233_abnormal_nose_morphology1.44080338
35MP0002734_abnormal_mechanical_nocicepti1.41845464
36MP0008789_abnormal_olfactory_epithelium1.41514212
37MP0003787_abnormal_imprinting1.41052942
38MP0005394_taste/olfaction_phenotype1.40241445
39MP0005499_abnormal_olfactory_system1.40241445
40MP0004145_abnormal_muscle_electrophysio1.39309572
41MP0005248_abnormal_Harderian_gland1.37778270
42MP0003942_abnormal_urinary_system1.36054521
43MP0002184_abnormal_innervation1.34798261
44MP0001188_hyperpigmentation1.32285611
45MP0003567_abnormal_fetal_cardiomyocyte1.29340764
46MP0003385_abnormal_body_wall1.28423123
47MP0002063_abnormal_learning/memory/cond1.27466730
48MP0003755_abnormal_palate_morphology1.27326034
49MP0003878_abnormal_ear_physiology1.26954417
50MP0005377_hearing/vestibular/ear_phenot1.26954417
51MP0001486_abnormal_startle_reflex1.25520527
52MP0009672_abnormal_birth_weight1.24593423
53MP0002152_abnormal_brain_morphology1.23678396
54MP0001286_abnormal_eye_development1.22317538
55MP0000534_abnormal_ureter_morphology1.19513284
56MP0005187_abnormal_penis_morphology1.17936009
57MP0002249_abnormal_larynx_morphology1.17634611
58MP0002751_abnormal_autonomic_nervous1.17097769
59MP0003123_paternal_imprinting1.14061305
60MP0003283_abnormal_digestive_organ1.13627116
61MP0000428_abnormal_craniofacial_morphol1.11410289
62MP0001485_abnormal_pinna_reflex1.10995137
63MP0002116_abnormal_craniofacial_bone1.10861097
64MP0002882_abnormal_neuron_morphology1.10801154
65MP0003646_muscle_fatigue1.10315753
66MP0002736_abnormal_nociception_after1.10217240
67MP0002557_abnormal_social/conspecific_i1.09128807
68MP0009250_abnormal_appendicular_skeleto1.08638980
69MP0000026_abnormal_inner_ear1.08313663
70MP0002572_abnormal_emotion/affect_behav1.07633596
71MP0002102_abnormal_ear_morphology1.06988241
72MP0004811_abnormal_neuron_physiology1.05581156
73MP0002638_abnormal_pupillary_reflex1.05383311
74MP0002752_abnormal_somatic_nervous1.05267305
75MP0001346_abnormal_lacrimal_gland1.03918815
76MP0009745_abnormal_behavioral_response1.02116820
77MP0002081_perinatal_lethality1.01444215
78MP0003935_abnormal_craniofacial_develop1.01182980
79MP0002272_abnormal_nervous_system0.99608798
80MP0000579_abnormal_nail_morphology0.99488809
81MP0002092_abnormal_eye_morphology0.99423907
82MP0001177_atelectasis0.99287215
83MP0008877_abnormal_DNA_methylation0.98559701
84MP0004858_abnormal_nervous_system0.97464713
85MP0002111_abnormal_tail_morphology0.95734460
86MP0009053_abnormal_anal_canal0.93896712
87MP0002064_seizures0.93835713
88MP0009703_decreased_birth_body0.92999829
89MP0002085_abnormal_embryonic_tissue0.91396099
90MP0002735_abnormal_chemical_nociception0.88907618
91MP0002067_abnormal_sensory_capabilities0.88088051
92MP0001968_abnormal_touch/_nociception0.87514064
93MP0005391_vision/eye_phenotype0.85780224
94MP0000432_abnormal_head_morphology0.85712515
95MP0002084_abnormal_developmental_patter0.84474544
96MP0003315_abnormal_perineum_morphology0.80863474
97MP0002932_abnormal_joint_morphology0.80795210
98MP0001963_abnormal_hearing_physiology0.80258576
99MP0003941_abnormal_skin_development0.78279405
100MP0001502_abnormal_circadian_rhythm0.76722839

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.55285355
2Hepatoblastoma (HP:0002884)2.97951434
3Abnormality of the labia minora (HP:0012880)2.79676627
4Short 4th metacarpal (HP:0010044)2.71966235
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71966235
6Cortical dysplasia (HP:0002539)2.66797295
7Calcaneovalgus deformity (HP:0001848)2.58474826
8Myokymia (HP:0002411)2.55536115
9Cutaneous finger syndactyly (HP:0010554)2.55073228
10Anophthalmia (HP:0000528)2.53321095
11High anterior hairline (HP:0009890)2.47793425
12Cutaneous syndactyly (HP:0012725)2.46539519
13Optic nerve hypoplasia (HP:0000609)2.41035231
14Trigonocephaly (HP:0000243)2.38119009
15Turricephaly (HP:0000262)2.36967533
16Absent septum pellucidum (HP:0001331)2.36710604
17Exercise-induced muscle cramps (HP:0003710)2.32249233
18Deformed tarsal bones (HP:0008119)2.32108020
19Abnormality of the 4th metacarpal (HP:0010012)2.26597265
20Muscle fiber inclusion bodies (HP:0100299)2.23439952
21Focal motor seizures (HP:0011153)2.22608307
22Maternal diabetes (HP:0009800)2.21926209
23Coronal craniosynostosis (HP:0004440)2.20594337
24Rib fusion (HP:0000902)2.18791896
25Nemaline bodies (HP:0003798)2.18776876
26Choanal stenosis (HP:0000452)2.17060114
27Colon cancer (HP:0003003)2.16968352
28Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14151069
29Shallow orbits (HP:0000586)2.13860442
30Midline defect of the nose (HP:0004122)2.13132436
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.13067372
32Renal hypoplasia (HP:0000089)2.12749527
33Abnormality of the septum pellucidum (HP:0007375)2.12679892
34Partial duplication of the phalanx of hand (HP:0009999)2.08736837
35Partial duplication of thumb phalanx (HP:0009944)2.08193641
36Vitreoretinal degeneration (HP:0000655)2.07783656
37Aplasia/Hypoplasia of the sternum (HP:0006714)1.99922130
38Type 1 muscle fiber predominance (HP:0003803)1.96601438
39Morphological abnormality of the middle ear (HP:0008609)1.94259806
40Distal arthrogryposis (HP:0005684)1.92644899
41Bilateral microphthalmos (HP:0007633)1.91575154
42Broad thumb (HP:0011304)1.91486850
43Abnormality of the calcaneus (HP:0008364)1.90293556
44Bifid tongue (HP:0010297)1.89344308
45Abnormal number of incisors (HP:0011064)1.88413189
46Rimmed vacuoles (HP:0003805)1.86732958
47Preaxial foot polydactyly (HP:0001841)1.85763011
48Drooling (HP:0002307)1.84916640
49Intestinal atresia (HP:0011100)1.84278698
50Aplasia of the phalanges of the hand (HP:0009802)1.84249793
51Aplasia involving bones of the extremities (HP:0009825)1.84249793
52Aplasia involving bones of the upper limbs (HP:0009823)1.84249793
53Broad metatarsal (HP:0001783)1.81742820
54Limb dystonia (HP:0002451)1.81117549
55Aqueductal stenosis (HP:0002410)1.78921338
56Focal seizures (HP:0007359)1.78652106
57Bronchomalacia (HP:0002780)1.78603334
58Abdominal situs inversus (HP:0003363)1.78025587
59Abnormality of abdominal situs (HP:0011620)1.78025587
60Vaginal atresia (HP:0000148)1.76882307
61Omphalocele (HP:0001539)1.75891657
62Broad finger (HP:0001500)1.75143461
63Hemivertebrae (HP:0002937)1.74917166
64Esophageal atresia (HP:0002032)1.73549362
65Sleep apnea (HP:0010535)1.73142021
66Broad phalanges of the hand (HP:0009768)1.72853059
67Myelomeningocele (HP:0002475)1.72326195
68Split foot (HP:0001839)1.71827168
69Abnormality of the aortic arch (HP:0012303)1.69530742
70Genital tract atresia (HP:0001827)1.68726199
71Abnormality of the ischium (HP:0003174)1.68403559
72Broad long bones (HP:0005622)1.68180119
73Oligodactyly (HP:0012165)1.67335685
74Supernumerary spleens (HP:0009799)1.67270917
75Abnormal lung lobation (HP:0002101)1.65660464
76Abnormality of the diencephalon (HP:0010662)1.64806039
77Shawl scrotum (HP:0000049)1.63866163
78Broad phalanx (HP:0006009)1.62947820
79Broad-based gait (HP:0002136)1.61720871
80Oligodactyly (hands) (HP:0001180)1.58654921
81Abnormal hair whorl (HP:0010721)1.58404667
82Gait imbalance (HP:0002141)1.58320950
83Anencephaly (HP:0002323)1.57938823
84Excessive salivation (HP:0003781)1.57860774
85Difficulty running (HP:0009046)1.57224091
86Micropenis (HP:0000054)1.56694235
87Fetal akinesia sequence (HP:0001989)1.56491270
88Myotonia (HP:0002486)1.56089708
89Overriding aorta (HP:0002623)1.55330241
90Abnormality of the pubic bones (HP:0003172)1.54945517
91True hermaphroditism (HP:0010459)1.54847395
92Megalencephaly (HP:0001355)1.54398201
93Abnormality of the antihelix (HP:0009738)1.53811418
94Labial hypoplasia (HP:0000066)1.53691318
95Broad foot (HP:0001769)1.53354991
96Scrotal hypoplasia (HP:0000046)1.52566323
97Growth hormone deficiency (HP:0000824)1.52508206
98Generalized hypotonia (HP:0001290)1.52386936
99Abnormality of the lower motor neuron (HP:0002366)1.51424865
100Tracheomalacia (HP:0002779)1.50854592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.54697724
2MARK14.03996119
3TNIK3.32810354
4DYRK22.57083736
5PNCK2.45988710
6EPHB22.40841901
7NTRK22.10224319
8EPHA42.06510821
9MAP3K102.02623826
10OBSCN1.94465412
11MKNK11.91540483
12MKNK21.91167676
13WNK31.89068591
14MAP3K41.83519710
15TYRO31.75137008
16FGFR21.65377244
17CDK191.65359683
18NTRK11.60893760
19PHKG21.58315816
20PHKG11.58315816
21LATS21.56070451
22CDC71.55334383
23MAP2K71.42913740
24BCR1.35837274
25CAMK1G1.30243329
26UHMK11.26176452
27DYRK31.24732446
28NTRK31.23927849
29MAPK131.18505742
30BRD41.13824558
31STK38L1.10637823
32DYRK1B1.04413514
33DYRK1A1.03275896
34PINK11.01918960
35CSNK1G21.01231171
36SRPK11.00551303
37TSSK60.98896602
38CAMK1D0.94904774
39PRKCG0.93717151
40MINK10.92904895
41DMPK0.91237806
42PLK30.90652066
43PKN10.90306203
44INSRR0.85476633
45SGK4940.83609735
46SGK2230.83609735
47WEE10.82297602
48TTK0.82290556
49CSNK1G10.81719996
50FGFR10.81475065
51LATS10.81300407
52MAPK150.79693471
53TIE10.79586776
54CDK50.74345180
55MAP2K40.73360664
56TAF10.73226965
57CDK11A0.69289553
58CDK150.69216525
59CDK180.68194824
60PRKD30.67685144
61VRK10.66528693
62CSNK1G30.62836894
63CAMK10.62701143
64TTN0.60020833
65SGK20.58884879
66CDK140.58237071
67NME10.57130355
68ERBB20.56960761
69PLK20.54488981
70CSNK1A1L0.53953306
71PDGFRA0.53776365
72PLK40.52848423
73PRKDC0.52833249
74PASK0.52324731
75CSNK1E0.51764707
76ICK0.50728673
77PLK10.50345098
78CHEK20.49115891
79MAP3K90.49021770
80PAK30.47457713
81ROCK20.47180486
82ZAK0.46379327
83KSR10.45777241
84CAMK40.45735610
85CAMK2A0.45460890
86VRK20.45115319
87STK110.43959000
88MARK20.43856564
89CDK10.43629187
90TRIM280.43388063
91NLK0.42299811
92CAMK2B0.41819111
93STK30.41486740
94CDK30.41090582
95GSK3B0.40995901
96BRSK20.40794300
97BUB10.40544135
98EEF2K0.40280952
99NEK20.39210440
100CDK20.39205194

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.05323857
2Hedgehog signaling pathway_Homo sapiens_hsa043402.60778324
3Nicotine addiction_Homo sapiens_hsa050332.55600138
4Axon guidance_Homo sapiens_hsa043602.12331332
5Cardiac muscle contraction_Homo sapiens_hsa042602.08381906
6Hippo signaling pathway_Homo sapiens_hsa043902.02467577
7Wnt signaling pathway_Homo sapiens_hsa043101.86108070
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.76829591
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75545508
10Circadian entrainment_Homo sapiens_hsa047131.66377834
11Glutamatergic synapse_Homo sapiens_hsa047241.58338463
12GABAergic synapse_Homo sapiens_hsa047271.57462385
13Melanogenesis_Homo sapiens_hsa049161.52835804
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49201937
15Dilated cardiomyopathy_Homo sapiens_hsa054141.41956560
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38218766
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37941734
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36985500
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36724921
20Tight junction_Homo sapiens_hsa045301.35902436
21Adherens junction_Homo sapiens_hsa045201.35793643
22Steroid biosynthesis_Homo sapiens_hsa001001.33524715
23Cocaine addiction_Homo sapiens_hsa050301.30963006
24Dopaminergic synapse_Homo sapiens_hsa047281.29837709
25Morphine addiction_Homo sapiens_hsa050321.28512069
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23818934
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20885783
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17792968
29Parkinsons disease_Homo sapiens_hsa050121.16972053
30Gap junction_Homo sapiens_hsa045401.15203400
31Spliceosome_Homo sapiens_hsa030401.15121619
32mRNA surveillance pathway_Homo sapiens_hsa030151.12924802
33Amphetamine addiction_Homo sapiens_hsa050311.06700209
34Notch signaling pathway_Homo sapiens_hsa043301.06229569
35Cholinergic synapse_Homo sapiens_hsa047251.04696369
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01935763
37Taste transduction_Homo sapiens_hsa047421.01551278
38Propanoate metabolism_Homo sapiens_hsa006401.01500597
39Insulin secretion_Homo sapiens_hsa049111.00000261
40Huntingtons disease_Homo sapiens_hsa050160.97492256
41Oocyte meiosis_Homo sapiens_hsa041140.97140685
42Phototransduction_Homo sapiens_hsa047440.96554398
43Oxidative phosphorylation_Homo sapiens_hsa001900.95960404
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94780369
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94656808
46Colorectal cancer_Homo sapiens_hsa052100.94159308
47Lysine degradation_Homo sapiens_hsa003100.92371372
48Oxytocin signaling pathway_Homo sapiens_hsa049210.91947686
49Mismatch repair_Homo sapiens_hsa034300.88371033
50Cell cycle_Homo sapiens_hsa041100.87758910
51Alzheimers disease_Homo sapiens_hsa050100.86697834
52cAMP signaling pathway_Homo sapiens_hsa040240.86536719
53Alcoholism_Homo sapiens_hsa050340.85328177
54Protein digestion and absorption_Homo sapiens_hsa049740.85233744
55TGF-beta signaling pathway_Homo sapiens_hsa043500.84806652
56Basal transcription factors_Homo sapiens_hsa030220.83301611
57Long-term depression_Homo sapiens_hsa047300.82628142
58Serotonergic synapse_Homo sapiens_hsa047260.82363266
59RNA transport_Homo sapiens_hsa030130.79852653
60RNA polymerase_Homo sapiens_hsa030200.79520157
61Gastric acid secretion_Homo sapiens_hsa049710.76630635
62ECM-receptor interaction_Homo sapiens_hsa045120.76422228
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76365107
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75169421
65Long-term potentiation_Homo sapiens_hsa047200.73253665
66Ribosome_Homo sapiens_hsa030100.72492661
67MicroRNAs in cancer_Homo sapiens_hsa052060.72167350
68Circadian rhythm_Homo sapiens_hsa047100.70648888
69Pyruvate metabolism_Homo sapiens_hsa006200.69818177
70Fanconi anemia pathway_Homo sapiens_hsa034600.67940522
71RNA degradation_Homo sapiens_hsa030180.66621726
72DNA replication_Homo sapiens_hsa030300.66185050
73Calcium signaling pathway_Homo sapiens_hsa040200.65096094
74Rap1 signaling pathway_Homo sapiens_hsa040150.64787448
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64533613
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63869201
77Pathways in cancer_Homo sapiens_hsa052000.62851411
78Endometrial cancer_Homo sapiens_hsa052130.61298831
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60403256
80Glucagon signaling pathway_Homo sapiens_hsa049220.59830311
81AMPK signaling pathway_Homo sapiens_hsa041520.58645042
82Biosynthesis of amino acids_Homo sapiens_hsa012300.58117522
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58102281
84Protein export_Homo sapiens_hsa030600.57905968
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57618028
86Ras signaling pathway_Homo sapiens_hsa040140.57538892
87Non-homologous end-joining_Homo sapiens_hsa034500.56372492
88Butanoate metabolism_Homo sapiens_hsa006500.53538933
89Melanoma_Homo sapiens_hsa052180.53470025
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53467122
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53080968
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52295554
93Synaptic vesicle cycle_Homo sapiens_hsa047210.51891234
94Nitrogen metabolism_Homo sapiens_hsa009100.49973685
95Olfactory transduction_Homo sapiens_hsa047400.49446155
96Arginine and proline metabolism_Homo sapiens_hsa003300.49283391
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48618925
98ErbB signaling pathway_Homo sapiens_hsa040120.48514456
99Base excision repair_Homo sapiens_hsa034100.48136549
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.46937960

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