ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	5.95903875
2	behavioral response to nicotine (GO:0035095)	4.47141245
3	glycerophospholipid catabolic process (GO:0046475)	4.21538385
4	response to pheromone (GO:0019236)	3.84954434
5	serotonin receptor signaling pathway (GO:0007210)	3.82884407
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.67659738
7	DNA double-strand break processing (GO:0000729)	3.59590883
8	postsynaptic membrane organization (GO:0001941)	3.45995845
9	protein-cofactor linkage (GO:0018065)	3.43965635
10	detection of light stimulus involved in sensory perception (GO:0050962)	3.41833241
11	detection of light stimulus involved in visual perception (GO:0050908)	3.41833241
12	replication fork processing (GO:0031297)	3.41830284
13	platelet dense granule organization (GO:0060155)	3.39724355
14	retinal cone cell development (GO:0046549)	3.32824654
15	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.32632986
16	startle response (GO:0001964)	3.28252272
17	regulation of glucokinase activity (GO:0033131)	3.24658908
18	regulation of hexokinase activity (GO:1903299)	3.24658908
19	hindbrain development (GO:0030902)	3.20725317
20	sulfation (GO:0051923)	3.14153392
21	regulation of appetite (GO:0032098)	3.14000809
22	presynaptic membrane assembly (GO:0097105)	3.13791634
23	gamma-aminobutyric acid transport (GO:0015812)	3.12967107
24	nonmotile primary cilium assembly (GO:0035058)	3.12957670
25	adaptation of signaling pathway (GO:0023058)	3.11136107
26	neural tube formation (GO:0001841)	3.04220820
27	fucose catabolic process (GO:0019317)	3.03812438
28	L-fucose metabolic process (GO:0042354)	3.03812438
29	L-fucose catabolic process (GO:0042355)	3.03812438
30	photoreceptor cell maintenance (GO:0045494)	3.01020106
31	negative regulation of circadian rhythm (GO:0042754)	2.99797322
32	piRNA metabolic process (GO:0034587)	2.97058087
33	pyrimidine nucleobase catabolic process (GO:0006208)	2.95497145
34	cilium morphogenesis (GO:0060271)	2.94413967
35	negative regulation of mast cell activation (GO:0033004)	2.91470837
36	neuron fate determination (GO:0048664)	2.90224600
37	cilium or flagellum-dependent cell motility (GO:0001539)	2.88592957
38	water-soluble vitamin biosynthetic process (GO:0042364)	2.87696145
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.87210533
40	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.84786639
41	cornea development in camera-type eye (GO:0061303)	2.83103775
42	synapsis (GO:0007129)	2.81963347
43	reflex (GO:0060004)	2.81127677
44	indolalkylamine metabolic process (GO:0006586)	2.77911380
45	protein K6-linked ubiquitination (GO:0085020)	2.76724738
46	indole-containing compound catabolic process (GO:0042436)	2.74620910
47	indolalkylamine catabolic process (GO:0046218)	2.74620910
48	tryptophan catabolic process (GO:0006569)	2.74620910
49	epithelial cilium movement (GO:0003351)	2.73334110
50	neuronal action potential (GO:0019228)	2.73073506
51	proline transport (GO:0015824)	2.71582341
52	presynaptic membrane organization (GO:0097090)	2.70521442
53	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.67706101
54	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.67482330
55	cellular ketone body metabolic process (GO:0046950)	2.66001359
56	protein complex biogenesis (GO:0070271)	2.65710895
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65640602
58	NADH dehydrogenase complex assembly (GO:0010257)	2.65640602
59	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65640602
60	DNA methylation involved in gamete generation (GO:0043046)	2.64742665
61	cilium organization (GO:0044782)	2.64032986
62	intraciliary transport (GO:0042073)	2.63542390
63	cilium assembly (GO:0042384)	2.61180233
64	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.60100566
65	righting reflex (GO:0060013)	2.57918456
66	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.57560886
67	mitochondrial respiratory chain complex assembly (GO:0033108)	2.56840818
68	C4-dicarboxylate transport (GO:0015740)	2.53300839
69	retinal ganglion cell axon guidance (GO:0031290)	2.52810830
70	regulation of cilium movement (GO:0003352)	2.52626470
71	thyroid hormone metabolic process (GO:0042403)	2.52219134
72	positive regulation of mitochondrial fission (GO:0090141)	2.52091957
73	regulation of hippo signaling (GO:0035330)	2.51363788
74	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.49853805
75	protein localization to cilium (GO:0061512)	2.49382611
76	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.49359130
77	neuronal action potential propagation (GO:0019227)	2.48104595
78	protein polyglutamylation (GO:0018095)	2.47963219
79	photoreceptor cell development (GO:0042461)	2.47310095
80	cysteine metabolic process (GO:0006534)	2.46622319
81	behavioral response to ethanol (GO:0048149)	2.46421130
82	male meiosis (GO:0007140)	2.45962021
83	nucleobase catabolic process (GO:0046113)	2.45365507
84	regulation of collateral sprouting (GO:0048670)	2.44582840
85	dopamine transport (GO:0015872)	2.43481886
86	reciprocal meiotic recombination (GO:0007131)	2.42571369
87	reciprocal DNA recombination (GO:0035825)	2.42571369
88	signal peptide processing (GO:0006465)	2.41213333
89	olfactory bulb development (GO:0021772)	2.39784775
90	respiratory chain complex IV assembly (GO:0008535)	2.38661279
91	anterograde synaptic vesicle transport (GO:0048490)	2.37622756
92	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.37308161
93	transmission of nerve impulse (GO:0019226)	2.37108551
94	axoneme assembly (GO:0035082)	2.37093833
95	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.37086269
96	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.37086269
97	maturation of 5.8S rRNA (GO:0000460)	2.35822585
98	seminiferous tubule development (GO:0072520)	2.35339081
99	neuron cell-cell adhesion (GO:0007158)	2.35212000
100	regulation of action potential (GO:0098900)	2.32754771

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.88736415
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.71476584
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.38547047
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.81905252
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.78134964
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.73755856
7	VDR_22108803_ChIP-Seq_LS180_Human	2.64062203
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.47110376
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.29659839
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24448556
11	EWS_26573619_Chip-Seq_HEK293_Human	2.19356102
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15938719
13	FUS_26573619_Chip-Seq_HEK293_Human	2.13730808
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12659263
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12657812
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11810849
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.10962308
18	P300_19829295_ChIP-Seq_ESCs_Human	2.07031445
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.02635870
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.95894696
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.93483989
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.80026958
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.78168435
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77396854
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75801602
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70188091
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68271158
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.67158776
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.63704241
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62550272
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62372368
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62045670
33	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.58678368
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58477042
35	STAT3_23295773_ChIP-Seq_U87_Human	1.55905973
36	* AR_25329375_ChIP-Seq_VCAP_Human	1.53407717
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51931474
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51187140
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.47089128
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46486377
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.43587576
42	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41963325
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41596736
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.41596736
45	TCF4_23295773_ChIP-Seq_U87_Human	1.39924141
46	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.38621226
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38492222
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37028479
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36522604
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34513142
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34309389
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33780679
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33182298
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.26723069
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26714695
56	* MYC_18940864_ChIP-ChIP_HL60_Human	1.26598580
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25781649
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24975967
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24699029
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24637991
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24637991
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24209297
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.22807838
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21734874
65	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21298825
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20669895
67	TP53_16413492_ChIP-PET_HCT116_Human	1.18954632
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18671207
69	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.17110453
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16747362
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16574468
72	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16465885
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16106945
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13812736
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13299222
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11680798
77	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.11635557
78	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07932193
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06929921
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06929921
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05173754
82	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04584584
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04102378
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01591272
85	* JUN_21703547_ChIP-Seq_K562_Human	1.00167998
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.00143642
87	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98974360
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98492211
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97897969
90	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97777356
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96985250
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96206878
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96206878
94	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95760520
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94612444
96	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.93859649
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93510983
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93017844
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.92097937
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.90618201

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.36849811
2	MP0000569_abnormal_digit_pigmentation	2.83974157
3	MP0001968_abnormal_touch/_nociception	2.50143065
4	MP0005551_abnormal_eye_electrophysiolog	2.42638666
5	MP0002234_abnormal_pharynx_morphology	2.42115990
6	MP0006292_abnormal_olfactory_placode	2.22640252
7	MP0006276_abnormal_autonomic_nervous	2.18918075
8	MP0002736_abnormal_nociception_after	2.16853504
9	MP0009046_muscle_twitch	2.08840622
10	MP0001984_abnormal_olfaction	2.00570667
11	MP0003880_abnormal_central_pattern	1.90358648
12	MP0002735_abnormal_chemical_nociception	1.89733058
13	MP0009745_abnormal_behavioral_response	1.89307329
14	MP0001986_abnormal_taste_sensitivity	1.82296097
15	MP0002938_white_spotting	1.82119314
16	MP0003195_calcinosis	1.81004017
17	MP0001486_abnormal_startle_reflex	1.80101149
18	MP0002272_abnormal_nervous_system	1.79356740
19	MP0004133_heterotaxia	1.78345379
20	MP0008875_abnormal_xenobiotic_pharmacok	1.74031575
21	MP0008789_abnormal_olfactory_epithelium	1.66807597
22	MP0002638_abnormal_pupillary_reflex	1.64340171
23	MP0000427_abnormal_hair_cycle	1.63606708
24	MP0002254_reproductive_system_inflammat	1.58904275
25	MP0004142_abnormal_muscle_tone	1.58840918
26	MP0005174_abnormal_tail_pigmentation	1.57724937
27	MP0002572_abnormal_emotion/affect_behav	1.55910695
28	MP0006072_abnormal_retinal_apoptosis	1.55425201
29	MP0005253_abnormal_eye_physiology	1.53893949
30	MP0002064_seizures	1.52269777
31	MP0000778_abnormal_nervous_system	1.49865808
32	MP0005084_abnormal_gallbladder_morpholo	1.49345684
33	MP0003183_abnormal_peptide_metabolism	1.47978565
34	MP0002102_abnormal_ear_morphology	1.47693761
35	MP0003718_maternal_effect	1.46442632
36	MP0000631_abnormal_neuroendocrine_gland	1.45032270
37	MP0001529_abnormal_vocalization	1.43520784
38	MP0002837_dystrophic_cardiac_calcinosis	1.37845675
39	MP0005645_abnormal_hypothalamus_physiol	1.37664442
40	MP0003787_abnormal_imprinting	1.36199231
41	MP0008872_abnormal_physiological_respon	1.35705884
42	MP0002876_abnormal_thyroid_physiology	1.33683733
43	MP0000566_synostosis	1.32031870
44	MP0005394_taste/olfaction_phenotype	1.29380804
45	MP0005499_abnormal_olfactory_system	1.29380804
46	MP0005389_reproductive_system_phenotype	1.29260778
47	MP0003635_abnormal_synaptic_transmissio	1.28766585
48	MP0003119_abnormal_digestive_system	1.27548806
49	MP0002557_abnormal_social/conspecific_i	1.26841282
50	MP0000372_irregular_coat_pigmentation	1.26602924
51	MP0003122_maternal_imprinting	1.25784246
52	MP0003937_abnormal_limbs/digits/tail_de	1.25380727
53	MP0000049_abnormal_middle_ear	1.24847528
54	MP0002928_abnormal_bile_duct	1.23494941
55	MP0001970_abnormal_pain_threshold	1.23451432
56	MP0004147_increased_porphyrin_level	1.23114539
57	MP0002734_abnormal_mechanical_nocicepti	1.22396745
58	MP0004885_abnormal_endolymph	1.22182224
59	MP0005646_abnormal_pituitary_gland	1.22053134
60	MP0001919_abnormal_reproductive_system	1.21519235
61	MP0003121_genomic_imprinting	1.19993686
62	MP0000383_abnormal_hair_follicle	1.18901743
63	MP0001501_abnormal_sleep_pattern	1.18568011
64	MP0002733_abnormal_thermal_nociception	1.18086855
65	MP0002067_abnormal_sensory_capabilities	1.17569733
66	MP0002063_abnormal_learning/memory/cond	1.13395683
67	MP0008058_abnormal_DNA_repair	1.12691823
68	MP0004924_abnormal_behavior	1.11603164
69	MP0005386_behavior/neurological_phenoty	1.11603164
70	MP0002160_abnormal_reproductive_system	1.10181769
71	MP0005195_abnormal_posterior_eye	1.06747794
72	MP0001485_abnormal_pinna_reflex	1.05415350
73	MP0001293_anophthalmia	1.03164953
74	MP0002653_abnormal_ependyma_morphology	1.02883120
75	MP0003011_delayed_dark_adaptation	1.02720195
76	MP0005310_abnormal_salivary_gland	1.02702724
77	MP0003283_abnormal_digestive_organ	1.01652136
78	MP0005423_abnormal_somatic_nervous	1.01543203
79	MP0004043_abnormal_pH_regulation	0.98837639
80	MP0004742_abnormal_vestibular_system	0.95839000
81	MP0002752_abnormal_somatic_nervous	0.95528670
82	MP0002184_abnormal_innervation	0.92984848
83	MP0001324_abnormal_eye_pigmentation	0.91429780
84	MP0003136_yellow_coat_color	0.90628456
85	MP0001905_abnormal_dopamine_level	0.90294647
86	MP0000026_abnormal_inner_ear	0.89967336
87	MP0003890_abnormal_embryonic-extraembry	0.88118260
88	MP0002751_abnormal_autonomic_nervous	0.87875878
89	MP0002233_abnormal_nose_morphology	0.87718585
90	MP0004145_abnormal_muscle_electrophysio	0.86718042
91	MP0002210_abnormal_sex_determination	0.85437532
92	MP0003698_abnormal_male_reproductive	0.84978461
93	MP0001764_abnormal_homeostasis	0.84385938
94	MP0005187_abnormal_penis_morphology	0.83282451
95	MP0001502_abnormal_circadian_rhythm	0.82585146
96	MP0003646_muscle_fatigue	0.81924991
97	MP0005377_hearing/vestibular/ear_phenot	0.80606550
98	MP0003878_abnormal_ear_physiology	0.80606550
99	MP0000647_abnormal_sebaceous_gland	0.80245779
100	MP0000516_abnormal_urinary_system	0.80149933

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.42520316
2	True hermaphroditism (HP:0010459)	4.39174141
3	Pancreatic cysts (HP:0001737)	4.33656016
4	Hyperventilation (HP:0002883)	4.14450219
5	Molar tooth sign on MRI (HP:0002419)	3.78281655
6	Abnormality of midbrain morphology (HP:0002418)	3.78281655
7	Nephronophthisis (HP:0000090)	3.49514147
8	Abolished electroretinogram (ERG) (HP:0000550)	3.35385492
9	Type II lissencephaly (HP:0007260)	3.30991289
10	Attenuation of retinal blood vessels (HP:0007843)	3.28528838
11	Chronic hepatic failure (HP:0100626)	3.26550425
12	Congenital stationary night blindness (HP:0007642)	3.12517442
13	Hyperglycinuria (HP:0003108)	2.96564326
14	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.89145620
15	Absent speech (HP:0001344)	2.83508478
16	Abnormality of the renal medulla (HP:0100957)	2.82681861
17	Medial flaring of the eyebrow (HP:0010747)	2.81561399
18	Abnormality of the labia minora (HP:0012880)	2.63369453
19	Hyperglycinemia (HP:0002154)	2.62640950
20	Bile duct proliferation (HP:0001408)	2.59372175
21	Abnormal biliary tract physiology (HP:0012439)	2.59372175
22	Cystic liver disease (HP:0006706)	2.58408856
23	Sclerocornea (HP:0000647)	2.58161192
24	Retinal dysplasia (HP:0007973)	2.49247818
25	Lissencephaly (HP:0001339)	2.48001965
26	Optic nerve hypoplasia (HP:0000609)	2.47803653
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.47321457
28	Gait imbalance (HP:0002141)	2.46490958
29	Male pseudohermaphroditism (HP:0000037)	2.43635772
30	Pendular nystagmus (HP:0012043)	2.41865957
31	Abnormality of serine family amino acid metabolism (HP:0010894)	2.39258791
32	Abnormality of glycine metabolism (HP:0010895)	2.39258791
33	Congenital primary aphakia (HP:0007707)	2.38454706
34	Focal motor seizures (HP:0011153)	2.34063442
35	Abnormality of the renal cortex (HP:0011035)	2.33061334
36	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.32561650
37	Congenital sensorineural hearing impairment (HP:0008527)	2.32514117
38	Cerebellar dysplasia (HP:0007033)	2.32294515
39	Genital tract atresia (HP:0001827)	2.29963754
40	Intestinal atresia (HP:0011100)	2.29951778
41	Keratoconus (HP:0000563)	2.29024697
42	Increased corneal curvature (HP:0100692)	2.29024697
43	Nephrogenic diabetes insipidus (HP:0009806)	2.28497665
44	Protruding tongue (HP:0010808)	2.26935497
45	Atonic seizures (HP:0010819)	2.26705089
46	Broad-based gait (HP:0002136)	2.26623756
47	Furrowed tongue (HP:0000221)	2.24761798
48	Inability to walk (HP:0002540)	2.24575703
49	Gonadotropin excess (HP:0000837)	2.23930217
50	Large for gestational age (HP:0001520)	2.23715953
51	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.23337235
52	Preaxial hand polydactyly (HP:0001177)	2.21796019
53	Occipital encephalocele (HP:0002085)	2.20183380
54	Anencephaly (HP:0002323)	2.18871360
55	Progressive inability to walk (HP:0002505)	2.16726069
56	Postaxial foot polydactyly (HP:0001830)	2.16347463
57	Abnormal drinking behavior (HP:0030082)	2.09468077
58	Polydipsia (HP:0001959)	2.09468077
59	Febrile seizures (HP:0002373)	2.07300483
60	Vaginal atresia (HP:0000148)	2.06338963
61	Drooling (HP:0002307)	2.06208993
62	Congenital hepatic fibrosis (HP:0002612)	2.05028388
63	Tubular atrophy (HP:0000092)	2.03885424
64	Decreased central vision (HP:0007663)	2.03341509
65	Hemiparesis (HP:0001269)	2.03311313
66	Abnormal respiratory epithelium morphology (HP:0012253)	2.01575632
67	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01575632
68	Fair hair (HP:0002286)	2.01038399
69	Dialeptic seizures (HP:0011146)	2.00971170
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98190638
71	Absent/shortened dynein arms (HP:0200106)	1.98190638
72	Gaze-evoked nystagmus (HP:0000640)	1.96065631
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.95089672
74	Postaxial hand polydactyly (HP:0001162)	1.93565870
75	Focal seizures (HP:0007359)	1.91501766
76	Abnormality of macular pigmentation (HP:0008002)	1.87211171
77	Patellar aplasia (HP:0006443)	1.86045663
78	Progressive cerebellar ataxia (HP:0002073)	1.84270059
79	Colon cancer (HP:0003003)	1.84066383
80	Dandy-Walker malformation (HP:0001305)	1.82765401
81	Clumsiness (HP:0002312)	1.82165663
82	Concave nail (HP:0001598)	1.81323988
83	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79489483
84	Excessive salivation (HP:0003781)	1.78696449
85	Gastrointestinal atresia (HP:0002589)	1.77281709
86	Abnormality of the pons (HP:0007361)	1.77234099
87	Aplasia/Hypoplasia of the patella (HP:0006498)	1.75513832
88	Hypothermia (HP:0002045)	1.74313995
89	Limb dystonia (HP:0002451)	1.73782794
90	Narrow forehead (HP:0000341)	1.73450560
91	Widely spaced teeth (HP:0000687)	1.72765385
92	Pachygyria (HP:0001302)	1.72237532
93	Poor coordination (HP:0002370)	1.71954299
94	Abnormality of alanine metabolism (HP:0010916)	1.71753781
95	Hyperalaninemia (HP:0003348)	1.71753781
96	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.71753781
97	Absence seizures (HP:0002121)	1.70174167
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69916009
99	Retinitis pigmentosa (HP:0000510)	1.69106521
100	Enlarged penis (HP:0000040)	1.68665754

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.41377547
2	WNK3	3.97898143
3	CASK	3.69673813
4	MAP4K2	3.27341793
5	BMPR1B	2.88978224
6	INSRR	2.42278874
7	ADRBK2	2.26862172
8	ZAK	2.22921902
9	PINK1	2.14638413
10	NUAK1	2.08859812
11	MAPK13	2.00595841
12	GRK1	1.92868814
13	MARK1	1.74534384
14	MAP3K4	1.72218303
15	NTRK3	1.69587585
16	TRIM28	1.68087241
17	TNIK	1.65032782
18	STK38L	1.58096625
19	BRSK2	1.52512280
20	PNCK	1.47493276
21	EIF2AK3	1.38634702
22	OXSR1	1.36732940
23	CSNK1G2	1.26741830
24	PLK2	1.26480828
25	MKNK2	1.25131087
26	CSNK1G1	1.21713721
27	PRKD3	1.21591080
28	TAF1	1.20086035
29	ACVR1B	1.20021906
30	BCR	1.16794499
31	PAK3	1.16240913
32	STK39	1.14490710
33	WNK4	1.14019412
34	PRKCE	1.13481405
35	EPHA4	1.12887742
36	DYRK2	1.11549380
37	CSNK1G3	1.09465425
38	ERBB3	1.08138747
39	MAP2K7	1.07042513
40	VRK1	1.05983405
41	TIE1	1.03426722
42	VRK2	1.01123014
43	TLK1	0.93764363
44	PLK4	0.89904482
45	NTRK2	0.88827873
46	CSNK1A1L	0.87768742
47	PLK3	0.86746202
48	PRKCG	0.84304802
49	ADRBK1	0.83199683
50	TXK	0.80703680
51	BCKDK	0.79692583
52	PTK2B	0.78781776
53	MAPKAPK5	0.75768815
54	MKNK1	0.74983244
55	PHKG1	0.74621580
56	PHKG2	0.74621580
57	TGFBR1	0.73540128
58	CHEK2	0.73212261
59	FGFR2	0.71690896
60	PRKCZ	0.71440553
61	WEE1	0.70520677
62	DAPK2	0.70155172
63	TSSK6	0.65868977
64	FER	0.64272848
65	PKN1	0.56100984
66	EPHB2	0.55634518
67	EIF2AK1	0.54772483
68	PIK3CA	0.53238997
69	EIF2AK2	0.52634014
70	GRK5	0.51788145
71	EPHA3	0.51596727
72	PRKCI	0.51349234
73	MINK1	0.50041132
74	CAMK2A	0.49578812
75	CSNK1A1	0.48446615
76	PIM2	0.47771756
77	RPS6KA5	0.47535768
78	CDK3	0.46720118
79	PLK1	0.46422922
80	PRKG1	0.45578588
81	CSNK1D	0.45252784
82	SRPK1	0.42104771
83	TEC	0.41821083
84	DYRK1A	0.39753171
85	CDK8	0.39212957
86	PRKACA	0.39038911
87	MAPKAPK3	0.37618846
88	ATR	0.36385565
89	STK3	0.35646797
90	CAMKK2	0.34810849
91	PRKCQ	0.33420568
92	CDK19	0.31449071
93	ATM	0.31174583
94	MAP2K4	0.31155524
95	DYRK3	0.31002930
96	PRKD2	0.29572178
97	IRAK1	0.28904780
98	PRKAA1	0.28182439
99	RPS6KA4	0.27933019
100	PRKCA	0.27705704

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.08427309
2	Butanoate metabolism_Homo sapiens_hsa00650	2.78974936
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.56397656
4	Nicotine addiction_Homo sapiens_hsa05033	2.53711341
5	Phototransduction_Homo sapiens_hsa04744	2.52721584
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.41479720
7	Protein export_Homo sapiens_hsa03060	2.35988416
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34830710
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24394574
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.20054516
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.11155030
12	Basal transcription factors_Homo sapiens_hsa03022	2.07573794
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01350754
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.96937621
15	RNA polymerase_Homo sapiens_hsa03020	1.91890339
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.83681505
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.82348450
18	Propanoate metabolism_Homo sapiens_hsa00640	1.79276960
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.74643145
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.70234648
21	Homologous recombination_Homo sapiens_hsa03440	1.69345298
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67301690
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.62788179
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.43875392
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.41661587
26	Taste transduction_Homo sapiens_hsa04742	1.39486106
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.39024766
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.36405260
29	Morphine addiction_Homo sapiens_hsa05032	1.27385918
30	Peroxisome_Homo sapiens_hsa04146	1.27188257
31	Parkinsons disease_Homo sapiens_hsa05012	1.26990549
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.22201772
33	Sulfur relay system_Homo sapiens_hsa04122	1.22183875
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19025085
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.17861993
36	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.10126330
37	Olfactory transduction_Homo sapiens_hsa04740	1.09548017
38	Circadian rhythm_Homo sapiens_hsa04710	1.09524241
39	Serotonergic synapse_Homo sapiens_hsa04726	1.07823278
40	GABAergic synapse_Homo sapiens_hsa04727	1.07086529
41	Regulation of autophagy_Homo sapiens_hsa04140	1.06439550
42	RNA degradation_Homo sapiens_hsa03018	1.06204582
43	Huntingtons disease_Homo sapiens_hsa05016	1.03350757
44	Caffeine metabolism_Homo sapiens_hsa00232	1.02957648
45	ABC transporters_Homo sapiens_hsa02010	1.00946801
46	Proteasome_Homo sapiens_hsa03050	0.99535136
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96969914
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.96188307
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.95478640
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94732177
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93574164
52	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.91404766
53	Sulfur metabolism_Homo sapiens_hsa00920	0.90593147
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84007564
55	Base excision repair_Homo sapiens_hsa03410	0.83386457
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82499408
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.80995722
58	Circadian entrainment_Homo sapiens_hsa04713	0.80892118
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80518685
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.79769276
61	Insulin secretion_Homo sapiens_hsa04911	0.78622302
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78388145
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.77460793
64	Mismatch repair_Homo sapiens_hsa03430	0.77078666
65	Salivary secretion_Homo sapiens_hsa04970	0.76463583
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.75974298
67	RNA transport_Homo sapiens_hsa03013	0.75801426
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74187346
69	Alzheimers disease_Homo sapiens_hsa05010	0.70685327
70	Metabolic pathways_Homo sapiens_hsa01100	0.70637519
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.70133522
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.67595964
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.65628136
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.63286619
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62148322
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61876555
77	Retinol metabolism_Homo sapiens_hsa00830	0.61740246
78	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.60883942
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60539523
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57194848
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57150273
82	Purine metabolism_Homo sapiens_hsa00230	0.56928745
83	Histidine metabolism_Homo sapiens_hsa00340	0.55377506
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.54603166
85	One carbon pool by folate_Homo sapiens_hsa00670	0.53978691
86	Fatty acid elongation_Homo sapiens_hsa00062	0.52483958
87	Fatty acid degradation_Homo sapiens_hsa00071	0.49990726
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47972207
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46928498
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.44721450
91	Cocaine addiction_Homo sapiens_hsa05030	0.43579269
92	Amphetamine addiction_Homo sapiens_hsa05031	0.42908895
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41027915
94	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40815228
95	Glutathione metabolism_Homo sapiens_hsa00480	0.40416515
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39900489
97	Long-term depression_Homo sapiens_hsa04730	0.39730517
98	Lysine degradation_Homo sapiens_hsa00310	0.39575040
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.38550590
100	Cholinergic synapse_Homo sapiens_hsa04725	0.38159743

ZNF425

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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