ZNF426

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.55638996
2behavioral response to nicotine (GO:0035095)4.57121560
3DNA double-strand break processing (GO:0000729)3.73272395
4protein polyglutamylation (GO:0018095)3.53238488
5L-fucose catabolic process (GO:0042355)3.47619560
6fucose catabolic process (GO:0019317)3.47619560
7L-fucose metabolic process (GO:0042354)3.47619560
8nonmotile primary cilium assembly (GO:0035058)3.43271082
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30804995
10indolalkylamine metabolic process (GO:0006586)3.29525087
11neural tube formation (GO:0001841)3.29367220
12epithelial cilium movement (GO:0003351)3.27632309
13DNA deamination (GO:0045006)3.26820533
14centriole replication (GO:0007099)3.25824021
15water-soluble vitamin biosynthetic process (GO:0042364)3.21530363
16kynurenine metabolic process (GO:0070189)3.19967240
17protein-cofactor linkage (GO:0018065)3.19200380
18regulation of cilium movement (GO:0003352)3.12128851
19tryptophan catabolic process (GO:0006569)3.10970692
20indole-containing compound catabolic process (GO:0042436)3.10970692
21indolalkylamine catabolic process (GO:0046218)3.10970692
22replication fork processing (GO:0031297)3.10334481
23sulfation (GO:0051923)3.07025661
24sperm motility (GO:0030317)3.06397002
25photoreceptor cell maintenance (GO:0045494)3.06257533
26gamma-aminobutyric acid transport (GO:0015812)3.03253398
27negative regulation of transcription regulatory region DNA binding (GO:2000678)2.96925845
28negative regulation of DNA-dependent DNA replication (GO:2000104)2.96702765
29negative regulation of telomere maintenance (GO:0032205)2.96227287
30multicellular organism reproduction (GO:0032504)2.88939136
31cellular ketone body metabolic process (GO:0046950)2.88673835
32regulation of nuclear cell cycle DNA replication (GO:0033262)2.87640229
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87500454
34RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87058478
35recombinational repair (GO:0000725)2.86927366
36double-strand break repair via homologous recombination (GO:0000724)2.86600321
37cilium morphogenesis (GO:0060271)2.85289133
38acrosome reaction (GO:0007340)2.83835512
39cilium organization (GO:0044782)2.81552031
40regulation of telomere maintenance (GO:0032204)2.81469481
41pyrimidine nucleobase catabolic process (GO:0006208)2.79983667
42axoneme assembly (GO:0035082)2.79467242
43regulation of gene silencing by RNA (GO:0060966)2.78845890
44regulation of posttranscriptional gene silencing (GO:0060147)2.78845890
45regulation of gene silencing by miRNA (GO:0060964)2.78845890
46regulation of hippo signaling (GO:0035330)2.78173503
47kidney morphogenesis (GO:0060993)2.77261462
48tryptophan metabolic process (GO:0006568)2.76952826
49cilium assembly (GO:0042384)2.74829912
50detection of light stimulus involved in sensory perception (GO:0050962)2.74654867
51detection of light stimulus involved in visual perception (GO:0050908)2.74654867
52cilium movement (GO:0003341)2.72099270
53negative regulation of translation, ncRNA-mediated (GO:0040033)2.71686302
54regulation of translation, ncRNA-mediated (GO:0045974)2.71686302
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71686302
56behavioral response to ethanol (GO:0048149)2.68546386
57protein K11-linked deubiquitination (GO:0035871)2.67951763
58single strand break repair (GO:0000012)2.65162811
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64206243
60regulation of centriole replication (GO:0046599)2.64124141
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.62003916
62NADH dehydrogenase complex assembly (GO:0010257)2.62003916
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62003916
64ketone body metabolic process (GO:1902224)2.61948230
65establishment of protein localization to Golgi (GO:0072600)2.61292084
66intraciliary transport (GO:0042073)2.60758016
67reciprocal DNA recombination (GO:0035825)2.60713585
68reciprocal meiotic recombination (GO:0007131)2.60713585
69pseudouridine synthesis (GO:0001522)2.60637277
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59904871
71regulation of mesoderm development (GO:2000380)2.57909430
72protein localization to cilium (GO:0061512)2.57131645
73protein complex biogenesis (GO:0070271)2.54324792
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52063964
75preassembly of GPI anchor in ER membrane (GO:0016254)2.50452774
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.50255869
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50255869
78piRNA metabolic process (GO:0034587)2.50188656
79mitochondrial respiratory chain complex assembly (GO:0033108)2.47378105
80regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45370705
81negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45272939
82retinal cone cell development (GO:0046549)2.44357624
83somite development (GO:0061053)2.44354358
84photoreceptor cell development (GO:0042461)2.43960871
85synapsis (GO:0007129)2.40859952
86respiratory chain complex IV assembly (GO:0008535)2.40388154
87indole-containing compound metabolic process (GO:0042430)2.40336979
88appendage development (GO:0048736)2.39834766
89limb development (GO:0060173)2.39834766
90protein K6-linked ubiquitination (GO:0085020)2.39604437
91regulation of meiosis I (GO:0060631)2.39339586
92negative regulation of systemic arterial blood pressure (GO:0003085)2.38887536
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38736631
94rhodopsin mediated signaling pathway (GO:0016056)2.38040977
95male meiosis I (GO:0007141)2.37920710
96regulation of collateral sprouting (GO:0048670)2.37313297
97spinal cord motor neuron differentiation (GO:0021522)2.35467311
98postreplication repair (GO:0006301)2.35152702
99regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.34904325
100regulation of mitotic spindle checkpoint (GO:1903504)2.34904325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.19364222
2GBX2_23144817_ChIP-Seq_PC3_Human3.08054278
3VDR_22108803_ChIP-Seq_LS180_Human2.87843027
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.77651769
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75712289
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53769888
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48378547
8FUS_26573619_Chip-Seq_HEK293_Human2.41321709
9EZH2_22144423_ChIP-Seq_EOC_Human2.38588513
10IGF1R_20145208_ChIP-Seq_DFB_Human2.32960295
11EWS_26573619_Chip-Seq_HEK293_Human2.29310580
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28558468
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27357886
14TAF15_26573619_Chip-Seq_HEK293_Human2.25465096
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.23555774
16P300_19829295_ChIP-Seq_ESCs_Human2.22513124
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11493004
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10690149
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05852996
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05415157
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.86380497
22* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79686647
23IRF1_19129219_ChIP-ChIP_H3396_Human1.77650677
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77542130
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71710527
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68227458
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.68193924
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66385437
29CBP_20019798_ChIP-Seq_JUKART_Human1.64901876
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64901876
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64394944
32ER_23166858_ChIP-Seq_MCF-7_Human1.63542869
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61739464
34SMAD4_21799915_ChIP-Seq_A2780_Human1.56550942
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.55465881
36STAT3_23295773_ChIP-Seq_U87_Human1.51805107
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51489280
38* NOTCH1_21737748_ChIP-Seq_TLL_Human1.50556667
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49419180
40MYC_18940864_ChIP-ChIP_HL60_Human1.48390949
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48156093
42ELK1_19687146_ChIP-ChIP_HELA_Human1.46018861
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45594853
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45505747
45AR_25329375_ChIP-Seq_VCAP_Human1.45467069
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45172087
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43306295
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43306295
49TCF4_23295773_ChIP-Seq_U87_Human1.40947356
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.39302690
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38015040
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35195779
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33920783
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32938821
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32350698
56NANOG_19829295_ChIP-Seq_ESCs_Human1.31940160
57SOX2_19829295_ChIP-Seq_ESCs_Human1.31940160
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31787599
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.30727450
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.28449670
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28341983
62TP53_22573176_ChIP-Seq_HFKS_Human1.28270565
63BCAT_22108803_ChIP-Seq_LS180_Human1.25858433
64TCF4_22108803_ChIP-Seq_LS180_Human1.25740943
65RUNX2_22187159_ChIP-Seq_PCA_Human1.25739973
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24762107
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22104702
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.22032731
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21023390
70* TP63_19390658_ChIP-ChIP_HaCaT_Human1.19340625
71* VDR_23849224_ChIP-Seq_CD4+_Human1.19089660
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.18097912
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18097912
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18071048
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.16528676
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15560383
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15242314
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14307973
79RNF2_27304074_Chip-Seq_NSC_Mouse1.12336058
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10395867
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.09136733
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.07786329
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07716630
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.06478264
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.06050995
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06014894
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05521248
88NCOR_22424771_ChIP-Seq_293T_Human1.05199646
89CDX2_22108803_ChIP-Seq_LS180_Human1.04638632
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03681659
91AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03448731
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02761299
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.02266988
94P53_22387025_ChIP-Seq_ESCs_Mouse1.01761530
95AR_21572438_ChIP-Seq_LNCaP_Human1.00124269
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99590481
97AR_20517297_ChIP-Seq_VCAP_Human0.99473837
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.98037865
99JUN_21703547_ChIP-Seq_K562_Human0.97479794
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.97378567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.24706396
2MP0008877_abnormal_DNA_methylation3.24180360
3MP0002102_abnormal_ear_morphology2.99937307
4MP0003195_calcinosis2.38074726
5MP0000569_abnormal_digit_pigmentation2.32643279
6MP0005551_abnormal_eye_electrophysiolog2.27835056
7MP0001968_abnormal_touch/_nociception2.21588016
8MP0003646_muscle_fatigue2.20912512
9MP0006072_abnormal_retinal_apoptosis2.14369116
10MP0002736_abnormal_nociception_after2.10303043
11MP0002837_dystrophic_cardiac_calcinosis1.96794256
12MP0005646_abnormal_pituitary_gland1.90781298
13MP0003787_abnormal_imprinting1.88155541
14MP0005410_abnormal_fertilization1.86172544
15MP0005253_abnormal_eye_physiology1.84475789
16MP0002938_white_spotting1.74459506
17MP0008058_abnormal_DNA_repair1.73841322
18MP0004133_heterotaxia1.72802238
19MP0003136_yellow_coat_color1.70340252
20MP0008789_abnormal_olfactory_epithelium1.68055705
21MP0006276_abnormal_autonomic_nervous1.65828643
22MP0000631_abnormal_neuroendocrine_gland1.63903615
23MP0002638_abnormal_pupillary_reflex1.63416253
24MP0003880_abnormal_central_pattern1.60511083
25MP0009046_muscle_twitch1.58332647
26MP0008872_abnormal_physiological_respon1.55707798
27MP0004142_abnormal_muscle_tone1.55700623
28MP0001485_abnormal_pinna_reflex1.52876001
29MP0003718_maternal_effect1.49392250
30MP0005084_abnormal_gallbladder_morpholo1.49112892
31MP0000372_irregular_coat_pigmentation1.48168548
32MP0000427_abnormal_hair_cycle1.45618028
33MP0001529_abnormal_vocalization1.45569289
34MP0004043_abnormal_pH_regulation1.45201570
35MP0002160_abnormal_reproductive_system1.43341687
36MP0002272_abnormal_nervous_system1.43177232
37MP0001984_abnormal_olfaction1.42473856
38MP0001293_anophthalmia1.42429216
39MP0003890_abnormal_embryonic-extraembry1.41024197
40MP0009745_abnormal_behavioral_response1.38977240
41MP0002234_abnormal_pharynx_morphology1.36050028
42MP0001188_hyperpigmentation1.34799761
43MP0003121_genomic_imprinting1.34737937
44MP0003119_abnormal_digestive_system1.29778962
45MP0001986_abnormal_taste_sensitivity1.29156723
46MP0003567_abnormal_fetal_cardiomyocyte1.29098979
47MP0003937_abnormal_limbs/digits/tail_de1.27254523
48MP0001486_abnormal_startle_reflex1.27101061
49MP0002163_abnormal_gland_morphology1.26509439
50MP0008057_abnormal_DNA_replication1.26057676
51MP0003698_abnormal_male_reproductive1.24946317
52MP0000049_abnormal_middle_ear1.24548199
53MP0005394_taste/olfaction_phenotype1.24414467
54MP0005499_abnormal_olfactory_system1.24414467
55MP0004885_abnormal_endolymph1.21184601
56MP0005645_abnormal_hypothalamus_physiol1.20902788
57MP0002876_abnormal_thyroid_physiology1.19566019
58MP0002653_abnormal_ependyma_morphology1.19527552
59MP0001929_abnormal_gametogenesis1.15372686
60MP0004145_abnormal_muscle_electrophysio1.13934490
61MP0005389_reproductive_system_phenotype1.12709561
62MP0002928_abnormal_bile_duct1.10592317
63MP0003011_delayed_dark_adaptation1.09891202
64MP0000778_abnormal_nervous_system1.08857162
65MP0004215_abnormal_myocardial_fiber1.07427703
66MP0005195_abnormal_posterior_eye1.07136008
67MP0002557_abnormal_social/conspecific_i1.06625452
68MP0004147_increased_porphyrin_level1.05898933
69MP0002095_abnormal_skin_pigmentation1.05563627
70MP0001501_abnormal_sleep_pattern1.04430255
71MP0000647_abnormal_sebaceous_gland1.02970203
72MP0002572_abnormal_emotion/affect_behav1.02105300
73MP0005187_abnormal_penis_morphology1.00937998
74MP0008995_early_reproductive_senescence0.99674894
75MP0008875_abnormal_xenobiotic_pharmacok0.99557183
76MP0005379_endocrine/exocrine_gland_phen0.97593477
77MP0001286_abnormal_eye_development0.96953323
78MP0005367_renal/urinary_system_phenotyp0.95116807
79MP0000516_abnormal_urinary_system0.95116807
80MP0002210_abnormal_sex_determination0.93638974
81MP0002735_abnormal_chemical_nociception0.93155565
82MP0005391_vision/eye_phenotype0.92946260
83MP0002752_abnormal_somatic_nervous0.92896434
84MP0002138_abnormal_hepatobiliary_system0.92836481
85MP0002751_abnormal_autonomic_nervous0.91271602
86MP0002067_abnormal_sensory_capabilities0.90548594
87MP0003137_abnormal_impulse_conducting0.90426483
88MP0005386_behavior/neurological_phenoty0.89739644
89MP0004924_abnormal_behavior0.89739644
90MP0005174_abnormal_tail_pigmentation0.89725757
91MP0002822_catalepsy0.88189038
92MP0000653_abnormal_sex_gland0.86678868
93MP0010094_abnormal_chromosome_stability0.86604071
94MP0000026_abnormal_inner_ear0.85505707
95MP0009697_abnormal_copulation0.84427734
96MP0003635_abnormal_synaptic_transmissio0.84397648
97MP0003122_maternal_imprinting0.81764681
98MP0001145_abnormal_male_reproductive0.80208314
99MP0005395_other_phenotype0.79501426
100MP0004742_abnormal_vestibular_system0.78276292

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.25476099
2Pancreatic fibrosis (HP:0100732)4.01608370
3True hermaphroditism (HP:0010459)3.65708364
4Abnormality of midbrain morphology (HP:0002418)3.64751103
5Molar tooth sign on MRI (HP:0002419)3.64751103
6Nephronophthisis (HP:0000090)3.45653196
7Abnormality of the renal medulla (HP:0100957)3.19127876
8Decreased circulating renin level (HP:0003351)3.13813967
9Medial flaring of the eyebrow (HP:0010747)3.13565384
10Abnormality of the renal cortex (HP:0011035)3.09451689
11Congenital stationary night blindness (HP:0007642)3.07749870
12Pendular nystagmus (HP:0012043)2.92706184
13Gait imbalance (HP:0002141)2.76711557
14Congenital primary aphakia (HP:0007707)2.74346732
15Attenuation of retinal blood vessels (HP:0007843)2.72726166
16Abolished electroretinogram (ERG) (HP:0000550)2.67324785
17Nephrogenic diabetes insipidus (HP:0009806)2.65602719
18Chronic hepatic failure (HP:0100626)2.58888022
19Genital tract atresia (HP:0001827)2.55121223
20Renal cortical cysts (HP:0000803)2.53081248
21Vaginal atresia (HP:0000148)2.48352921
22Cystic liver disease (HP:0006706)2.46838331
23Tubular atrophy (HP:0000092)2.44754370
24Keratoconus (HP:0000563)2.42197388
25Increased corneal curvature (HP:0100692)2.42197388
26Methylmalonic acidemia (HP:0002912)2.40305011
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.37820826
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.37096721
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35278514
30Abnormality of alanine metabolism (HP:0010916)2.35278514
31Hyperalaninemia (HP:0003348)2.35278514
32Type II lissencephaly (HP:0007260)2.34704104
33Abnormal rod and cone electroretinograms (HP:0008323)2.33988151
34Abnormal drinking behavior (HP:0030082)2.33399241
35Polydipsia (HP:0001959)2.33399241
36Decreased central vision (HP:0007663)2.30791075
37Sclerocornea (HP:0000647)2.29174938
38Progressive inability to walk (HP:0002505)2.28986484
39Bony spicule pigmentary retinopathy (HP:0007737)2.26861707
40Colon cancer (HP:0003003)2.23978646
41Congenital hepatic fibrosis (HP:0002612)2.23218098
42Postaxial foot polydactyly (HP:0001830)2.20432426
43Poor coordination (HP:0002370)2.17156565
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.16991937
45Absent/shortened dynein arms (HP:0200106)2.16991937
46Anencephaly (HP:0002323)2.16493694
47Genetic anticipation (HP:0003743)2.13546370
48Inability to walk (HP:0002540)2.12946118
49Abnormality of the labia minora (HP:0012880)2.12776191
50Small hand (HP:0200055)2.11936621
51Hyperventilation (HP:0002883)2.10135017
52Progressive cerebellar ataxia (HP:0002073)2.08426884
53Gaze-evoked nystagmus (HP:0000640)2.07499984
54Chronic bronchitis (HP:0004469)2.07144004
55Tubulointerstitial nephritis (HP:0001970)2.05025435
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.04266356
57Methylmalonic aciduria (HP:0012120)2.02505354
58Chorioretinal atrophy (HP:0000533)2.00117222
59Broad-based gait (HP:0002136)1.99727708
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98570228
61Abnormality of the ileum (HP:0001549)1.97234615
62Abnormal biliary tract physiology (HP:0012439)1.97002635
63Bile duct proliferation (HP:0001408)1.97002635
64Hypoplasia of the pons (HP:0012110)1.96777821
65Hypothermia (HP:0002045)1.96752134
66Astigmatism (HP:0000483)1.96595262
673-Methylglutaconic aciduria (HP:0003535)1.95534185
68Male pseudohermaphroditism (HP:0000037)1.95300394
69Optic nerve hypoplasia (HP:0000609)1.93747164
70Meckel diverticulum (HP:0002245)1.93380781
71Abnormality of macular pigmentation (HP:0008002)1.92901553
72Abnormality of the pons (HP:0007361)1.92872763
73Hyperglycinemia (HP:0002154)1.90800826
74Intestinal atresia (HP:0011100)1.90738553
75Postaxial hand polydactyly (HP:0001162)1.90674716
76Hypokalemic alkalosis (HP:0001949)1.90640901
77Lissencephaly (HP:0001339)1.90262052
78Protruding tongue (HP:0010808)1.89203042
79Supernumerary spleens (HP:0009799)1.89193052
80Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88814629
81Median cleft lip (HP:0000161)1.83915611
82Short tibia (HP:0005736)1.82639206
83Polyuria (HP:0000103)1.81152291
84Abnormality of chromosome stability (HP:0003220)1.80489441
85Abnormal ciliary motility (HP:0012262)1.79293425
86Preaxial hand polydactyly (HP:0001177)1.79288364
87Furrowed tongue (HP:0000221)1.78323744
88Abnormal respiratory motile cilium morphology (HP:0005938)1.78286108
89Abnormal respiratory epithelium morphology (HP:0012253)1.78286108
90Febrile seizures (HP:0002373)1.76420026
91Abnormality of renin-angiotensin system (HP:0000847)1.75939746
92Oligodactyly (hands) (HP:0001180)1.75509144
93Specific learning disability (HP:0001328)1.75014411
94Neoplasm of the adrenal cortex (HP:0100641)1.74927184
95Volvulus (HP:0002580)1.72591498
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.72518702
97Cerebellar dysplasia (HP:0007033)1.72376876
98Hyperkalemia (HP:0002153)1.70989673
99Stenosis of the external auditory canal (HP:0000402)1.69822457
100Oligohydramnios (HP:0001562)1.69349456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.19952128
2WNK33.26161011
3NUAK13.02611016
4ZAK2.74509029
5BMPR1B2.66864790
6MAP4K22.57548752
7ACVR1B2.55978682
8ADRBK22.30675367
9MAP3K41.90882921
10PLK41.89909851
11TAOK31.89705908
12CASK1.89109357
13GRK11.84464290
14INSRR1.80733627
15MKNK21.78785962
16AKT31.72496581
17TLK11.68646224
18WNK41.66121732
19STK391.53359238
20MAPK131.44647936
21TRIM281.44033046
22OXSR11.39695564
23BCR1.38867853
24BCKDK1.37596796
25PINK11.37019665
26MARK11.34020100
27BRSK21.33842849
28TNIK1.30144547
29STK38L1.26283381
30DYRK21.25949267
31PLK21.25172094
32MAP2K71.21671293
33VRK11.20347986
34PLK31.18937866
35EIF2AK31.13063363
36SRPK11.11355941
37MKNK11.07065659
38CSNK1G11.04404334
39PAK31.00553917
40CSNK1G20.98752004
41PRKCE0.93393004
42CSNK1G30.93276852
43TIE10.88537640
44CSNK1A1L0.85838914
45TGFBR10.84679026
46PRKCG0.80728393
47PNCK0.79536196
48ADRBK10.78007017
49SGK20.77885891
50MUSK0.76875757
51TEC0.76411193
52TXK0.72351025
53PLK10.70884843
54TSSK60.69961678
55WEE10.69919294
56DYRK30.64632448
57NEK20.64124332
58ERBB30.63905447
59STK30.60982670
60EPHA40.60424453
61TAF10.60343031
62NEK10.60023706
63CDC70.60010618
64NLK0.58699919
65PDK20.58477332
66OBSCN0.57647772
67FER0.57433450
68STK160.56282254
69LATS10.55626207
70FGFR20.54421083
71ATR0.54276559
72CHEK20.54121148
73NTRK30.53286669
74MST40.53065356
75TTK0.52906653
76SGK2230.52534765
77SGK4940.52534765
78CAMK2A0.50509674
79BUB10.50129760
80ATM0.48048767
81MAPK150.46831836
82RPS6KA50.46477753
83CAMKK20.46270166
84FLT30.45037741
85PHKG10.42800537
86PHKG20.42800537
87CSNK1A10.41996107
88PKN10.41944590
89PRKACA0.40534621
90PTK2B0.38820484
91CSNK1D0.37572116
92MAPKAPK50.37078103
93EPHA30.35536153
94PRKG10.35215315
95PRKCQ0.34451392
96CDK30.34198644
97DYRK1A0.33036284
98DAPK20.32790759
99VRK20.32680432
100NME10.32310453

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93110717
2Phototransduction_Homo sapiens_hsa047442.77998173
3Homologous recombination_Homo sapiens_hsa034402.40625639
4Fanconi anemia pathway_Homo sapiens_hsa034602.31085164
5Basal transcription factors_Homo sapiens_hsa030222.24771077
6Butanoate metabolism_Homo sapiens_hsa006502.21625832
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13936725
8Nitrogen metabolism_Homo sapiens_hsa009102.12723313
9Linoleic acid metabolism_Homo sapiens_hsa005912.04879272
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04488614
11Protein export_Homo sapiens_hsa030602.00964257
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00751846
13Selenocompound metabolism_Homo sapiens_hsa004501.99835194
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97456122
15Caffeine metabolism_Homo sapiens_hsa002321.95092966
16RNA polymerase_Homo sapiens_hsa030201.92276632
17Propanoate metabolism_Homo sapiens_hsa006401.87504599
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82543760
19Taste transduction_Homo sapiens_hsa047421.81889954
20Nicotine addiction_Homo sapiens_hsa050331.81169695
21Oxidative phosphorylation_Homo sapiens_hsa001901.79058539
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70834417
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69591599
24RNA degradation_Homo sapiens_hsa030181.68892748
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68160338
26Tryptophan metabolism_Homo sapiens_hsa003801.65862585
27Olfactory transduction_Homo sapiens_hsa047401.52552188
28Ether lipid metabolism_Homo sapiens_hsa005651.48418400
29Non-homologous end-joining_Homo sapiens_hsa034501.48361047
30Parkinsons disease_Homo sapiens_hsa050121.45102073
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44580887
32One carbon pool by folate_Homo sapiens_hsa006701.41528135
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34777851
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27050366
35Mismatch repair_Homo sapiens_hsa034301.26790214
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.25783373
37Huntingtons disease_Homo sapiens_hsa050161.15793177
38Morphine addiction_Homo sapiens_hsa050321.12635422
39Regulation of autophagy_Homo sapiens_hsa041401.04443138
40RNA transport_Homo sapiens_hsa030131.01934806
41Steroid biosynthesis_Homo sapiens_hsa001000.98957131
42Proteasome_Homo sapiens_hsa030500.98907224
43Peroxisome_Homo sapiens_hsa041460.97175171
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.95967813
45Purine metabolism_Homo sapiens_hsa002300.95456402
46GABAergic synapse_Homo sapiens_hsa047270.93821001
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.93759511
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.92657236
49Cardiac muscle contraction_Homo sapiens_hsa042600.86251719
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86020661
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84449386
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83261727
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81703154
54Serotonergic synapse_Homo sapiens_hsa047260.81590857
55Chemical carcinogenesis_Homo sapiens_hsa052040.79908388
56Nucleotide excision repair_Homo sapiens_hsa034200.79212452
57Alzheimers disease_Homo sapiens_hsa050100.79019947
58Glycerolipid metabolism_Homo sapiens_hsa005610.78673492
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77989769
60Retinol metabolism_Homo sapiens_hsa008300.77211763
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76602671
62Circadian entrainment_Homo sapiens_hsa047130.76247963
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76225503
64Sulfur relay system_Homo sapiens_hsa041220.75933417
65Insulin secretion_Homo sapiens_hsa049110.75557275
66ABC transporters_Homo sapiens_hsa020100.74375102
67Hedgehog signaling pathway_Homo sapiens_hsa043400.73891674
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73516650
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73367144
70beta-Alanine metabolism_Homo sapiens_hsa004100.72297706
71Pyrimidine metabolism_Homo sapiens_hsa002400.67276542
72Circadian rhythm_Homo sapiens_hsa047100.64940452
73Glutamatergic synapse_Homo sapiens_hsa047240.63700535
74Arachidonic acid metabolism_Homo sapiens_hsa005900.63349164
75Metabolic pathways_Homo sapiens_hsa011000.62451755
76p53 signaling pathway_Homo sapiens_hsa041150.60881560
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59554635
78Base excision repair_Homo sapiens_hsa034100.57725258
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55644741
80Ovarian steroidogenesis_Homo sapiens_hsa049130.55020467
81Salivary secretion_Homo sapiens_hsa049700.52747865
82Basal cell carcinoma_Homo sapiens_hsa052170.52547202
83Dopaminergic synapse_Homo sapiens_hsa047280.49484617
84Fat digestion and absorption_Homo sapiens_hsa049750.49251408
85Calcium signaling pathway_Homo sapiens_hsa040200.46604221
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45119344
87DNA replication_Homo sapiens_hsa030300.42875133
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.42867319
89Collecting duct acid secretion_Homo sapiens_hsa049660.42813995
90Histidine metabolism_Homo sapiens_hsa003400.42208403
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41401125
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39768590
93Lysine degradation_Homo sapiens_hsa003100.39194740
94Dorso-ventral axis formation_Homo sapiens_hsa043200.38614708
95TGF-beta signaling pathway_Homo sapiens_hsa043500.37053340
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35838320
97Fatty acid degradation_Homo sapiens_hsa000710.35552199
98Amphetamine addiction_Homo sapiens_hsa050310.35039846
99Fatty acid elongation_Homo sapiens_hsa000620.35017690
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34429065

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »