ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	preassembly of GPI anchor in ER membrane (GO:0016254)	6.69148033
2	neural tube formation (GO:0001841)	6.12926226
3	behavioral response to ethanol (GO:0048149)	5.78963679
4	mannosylation (GO:0097502)	5.72159956
5	cornea development in camera-type eye (GO:0061303)	5.50085928
6	righting reflex (GO:0060013)	5.30248545
7	GPI anchor metabolic process (GO:0006505)	4.64440001
8	limb bud formation (GO:0060174)	4.62187112
9	C-terminal protein amino acid modification (GO:0018410)	4.50054150
10	GPI anchor biosynthetic process (GO:0006506)	4.49923483
11	somite development (GO:0061053)	4.44186803
12	regulation of protein polyubiquitination (GO:1902914)	4.38573109
13	glial cell proliferation (GO:0014009)	4.34479500
14	C-terminal protein lipidation (GO:0006501)	4.29808309
15	adult feeding behavior (GO:0008343)	4.26650200
16	regulation of hippo signaling (GO:0035330)	4.23925040
17	tryptophan catabolic process (GO:0006569)	4.23232869
18	indole-containing compound catabolic process (GO:0042436)	4.23232869
19	indolalkylamine catabolic process (GO:0046218)	4.23232869
20	reflex (GO:0060004)	4.01233932
21	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.99391323
22	kynurenine metabolic process (GO:0070189)	3.98095584
23	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.97996027
24	L-fucose catabolic process (GO:0042355)	3.97501341
25	fucose catabolic process (GO:0019317)	3.97501341
26	L-fucose metabolic process (GO:0042354)	3.97501341
27	regulation of RIG-I signaling pathway (GO:0039535)	3.88523893
28	behavioral response to nicotine (GO:0035095)	3.87548827
29	indolalkylamine metabolic process (GO:0006586)	3.77588559
30	meiotic chromosome segregation (GO:0045132)	3.72411519
31	tryptophan metabolic process (GO:0006568)	3.69661254
32	estrogen biosynthetic process (GO:0006703)	3.58697946
33	protein localization to cilium (GO:0061512)	3.56352364
34	glycolipid biosynthetic process (GO:0009247)	3.45488200
35	photoreceptor cell maintenance (GO:0045494)	3.40154422
36	pyrimidine nucleobase catabolic process (GO:0006208)	3.39311853
37	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.36791093
38	histone H2A acetylation (GO:0043968)	3.27167895
39	embryonic epithelial tube formation (GO:0001838)	3.26698332
40	sympathetic nervous system development (GO:0048485)	3.23179248
41	respiratory chain complex IV assembly (GO:0008535)	3.20803701
42	detection of light stimulus involved in sensory perception (GO:0050962)	3.13821297
43	detection of light stimulus involved in visual perception (GO:0050908)	3.13821297
44	cellular ketone body metabolic process (GO:0046950)	3.13046176
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12050227
46	cytochrome complex assembly (GO:0017004)	3.11745199
47	water-soluble vitamin biosynthetic process (GO:0042364)	3.09443437
48	response to pheromone (GO:0019236)	3.06308847
49	epithelial tube formation (GO:0072175)	3.04049584
50	amine catabolic process (GO:0009310)	3.03303167
51	cellular biogenic amine catabolic process (GO:0042402)	3.03303167
52	photoreceptor cell development (GO:0042461)	2.99424399
53	nucleobase catabolic process (GO:0046113)	2.97396092
54	protein K11-linked deubiquitination (GO:0035871)	2.97066106
55	retinal cone cell development (GO:0046549)	2.90569540
56	cilium morphogenesis (GO:0060271)	2.89857630
57	necroptotic process (GO:0070266)	2.89771475
58	N-acetylglucosamine metabolic process (GO:0006044)	2.85472234
59	xenobiotic catabolic process (GO:0042178)	2.81923977
60	protein complex biogenesis (GO:0070271)	2.81808344
61	sulfation (GO:0051923)	2.81805411
62	ketone body metabolic process (GO:1902224)	2.80384664
63	cardiac ventricle formation (GO:0003211)	2.78426273
64	neuronal action potential (GO:0019228)	2.74232803
65	indole-containing compound metabolic process (GO:0042430)	2.71212374
66	heme transport (GO:0015886)	2.70450132
67	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.68746082
68	spinal cord development (GO:0021510)	2.66279135
69	gamma-aminobutyric acid transport (GO:0015812)	2.63501647
70	NIK/NF-kappaB signaling (GO:0038061)	2.63320100
71	protein targeting to vacuole (GO:0006623)	2.62576013
72	protein targeting to lysosome (GO:0006622)	2.62576013
73	establishment of protein localization to vacuole (GO:0072666)	2.62576013
74	regulation of hexokinase activity (GO:1903299)	2.59621970
75	regulation of glucokinase activity (GO:0033131)	2.59621970
76	cardiac chamber formation (GO:0003207)	2.59183091
77	epithelial cilium movement (GO:0003351)	2.57811203
78	cilium or flagellum-dependent cell motility (GO:0001539)	2.56744709
79	adaptation of signaling pathway (GO:0023058)	2.54367745
80	C4-dicarboxylate transport (GO:0015740)	2.53886756
81	protein prenylation (GO:0018342)	2.52838686
82	prenylation (GO:0097354)	2.52838686
83	axoneme assembly (GO:0035082)	2.51991540
84	DNA methylation involved in gamete generation (GO:0043046)	2.51922386
85	DNA double-strand break processing (GO:0000729)	2.51460937
86	negative regulation of necroptotic process (GO:0060546)	2.51440265
87	cilium organization (GO:0044782)	2.50861866
88	behavioral fear response (GO:0001662)	2.49007179
89	behavioral defense response (GO:0002209)	2.49007179
90	signal peptide processing (GO:0006465)	2.48997281
91	mitochondrial respiratory chain complex assembly (GO:0033108)	2.48053206
92	benzene-containing compound metabolic process (GO:0042537)	2.47994987
93	platelet dense granule organization (GO:0060155)	2.47569192
94	keratinocyte development (GO:0003334)	2.47174051
95	dopamine transport (GO:0015872)	2.46994828
96	aromatic amino acid family catabolic process (GO:0009074)	2.45484560
97	cilium assembly (GO:0042384)	2.45270301
98	nonmotile primary cilium assembly (GO:0035058)	2.44810393
99	piRNA metabolic process (GO:0034587)	2.43138291
100	mitotic cell cycle arrest (GO:0071850)	2.42886779

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.58928228
2	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.55032226
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.95455622
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.86076023
5	VDR_22108803_ChIP-Seq_LS180_Human	2.75275551
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.74962479
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.73062833
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.58288161
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56973853
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52361496
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.28205089
12	P300_19829295_ChIP-Seq_ESCs_Human	2.22798435
13	EWS_26573619_Chip-Seq_HEK293_Human	2.20705292
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20622715
15	FUS_26573619_Chip-Seq_HEK293_Human	2.19321249
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10765668
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01697345
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.97600251
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.97041987
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.86241325
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.80119675
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79041802
23	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.75665435
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69876460
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.69876460
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.69244150
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.69001394
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.65347539
29	AR_25329375_ChIP-Seq_VCAP_Human	1.63321894
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62815803
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62521888
32	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.61669403
33	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60275081
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.58848293
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57967842
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53072483
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52471118
38	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51582739
39	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47766091
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.47308760
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.45456957
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44246609
43	TCF4_23295773_ChIP-Seq_U87_Human	1.44168936
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43578030
45	STAT3_23295773_ChIP-Seq_U87_Human	1.42563383
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41187353
47	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.41108930
48	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.41108930
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40592041
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40109103
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39233563
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38635200
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38635200
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37561913
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36165519
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34382778
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34214954
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31366787
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.31075492
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29520491
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27764373
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.26779173
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21263278
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21263278
65	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20239985
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.19302137
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18800297
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18755388
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18352903
70	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.17663348
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15289863
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14690744
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13104702
74	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12725549
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12311972
76	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.09739511
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09123546
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.08287398
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08147182
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08024960
81	HTT_18923047_ChIP-ChIP_STHdh_Human	1.07642562
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.07225504
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06821480
84	NCOR_22424771_ChIP-Seq_293T_Human	1.06614696
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06212145
86	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05828229
87	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.05352000
88	AR_20517297_ChIP-Seq_VCAP_Human	1.05210859
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.05158478
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04834564
91	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04249014
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03950243
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02655214
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01804205
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01589445
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01098902
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00947646
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00549506
99	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99974902
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99552511

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.62903868
2	MP0003880_abnormal_central_pattern	3.17233471
3	MP0003195_calcinosis	3.07385378
4	MP0003787_abnormal_imprinting	2.95816027
5	MP0000372_irregular_coat_pigmentation	2.78055241
6	MP0005551_abnormal_eye_electrophysiolog	2.55712026
7	MP0006276_abnormal_autonomic_nervous	2.32568530
8	MP0006292_abnormal_olfactory_placode	2.28152491
9	MP0006072_abnormal_retinal_apoptosis	2.27217574
10	MP0001968_abnormal_touch/_nociception	2.22147483
11	MP0009046_muscle_twitch	2.11191256
12	MP0005253_abnormal_eye_physiology	2.08960930
13	MP0003646_muscle_fatigue	2.08843453
14	MP0002009_preneoplasia	2.05843307
15	MP0002736_abnormal_nociception_after	2.05591961
16	MP0002876_abnormal_thyroid_physiology	2.03419722
17	MP0003191_abnormal_cellular_cholesterol	1.94598529
18	MP0003718_maternal_effect	1.91541660
19	MP0000631_abnormal_neuroendocrine_gland	1.90847688
20	MP0004270_analgesia	1.89473581
21	MP0002102_abnormal_ear_morphology	1.87547798
22	MP0002938_white_spotting	1.87368402
23	MP0001986_abnormal_taste_sensitivity	1.84632749
24	MP0005646_abnormal_pituitary_gland	1.81743707
25	MP0005645_abnormal_hypothalamus_physiol	1.77755357
26	MP0002837_dystrophic_cardiac_calcinosis	1.72018646
27	MP0004142_abnormal_muscle_tone	1.70323461
28	MP0002751_abnormal_autonomic_nervous	1.64046363
29	MP0009745_abnormal_behavioral_response	1.60632224
30	MP0004043_abnormal_pH_regulation	1.59240515
31	MP0003011_delayed_dark_adaptation	1.57855648
32	MP0008872_abnormal_physiological_respon	1.53940645
33	MP0004147_increased_porphyrin_level	1.51562235
34	MP0002272_abnormal_nervous_system	1.50853771
35	MP0004885_abnormal_endolymph	1.46500119
36	MP0001529_abnormal_vocalization	1.46197047
37	MP0001501_abnormal_sleep_pattern	1.45939284
38	MP0003121_genomic_imprinting	1.45271315
39	MP0002735_abnormal_chemical_nociception	1.43377756
40	MP0008995_early_reproductive_senescence	1.36368513
41	MP0001485_abnormal_pinna_reflex	1.34506090
42	MP0001486_abnormal_startle_reflex	1.29845477
43	MP0001984_abnormal_olfaction	1.26797384
44	MP0002909_abnormal_adrenal_gland	1.24135706
45	MP0002064_seizures	1.22170765
46	MP0000383_abnormal_hair_follicle	1.21482430
47	MP0002734_abnormal_mechanical_nocicepti	1.19737737
48	MP0003137_abnormal_impulse_conducting	1.16987067
49	MP0001970_abnormal_pain_threshold	1.15059617
50	MP0002638_abnormal_pupillary_reflex	1.14875036
51	MP0000647_abnormal_sebaceous_gland	1.14170650
52	MP0000569_abnormal_digit_pigmentation	1.13351207
53	MP0003136_yellow_coat_color	1.12957020
54	MP0010386_abnormal_urinary_bladder	1.12367667
55	MP0002572_abnormal_emotion/affect_behav	1.11759877
56	MP0005386_behavior/neurological_phenoty	1.10628213
57	MP0004924_abnormal_behavior	1.10628213
58	MP0000778_abnormal_nervous_system	1.09296397
59	MP0002184_abnormal_innervation	1.04902046
60	MP0000427_abnormal_hair_cycle	1.03995416
61	MP0005647_abnormal_sex_gland	1.03576189
62	MP0003567_abnormal_fetal_cardiomyocyte	1.02873972
63	MP0004134_abnormal_chest_morphology	1.02709039
64	MP0002234_abnormal_pharynx_morphology	1.02441894
65	MP0003122_maternal_imprinting	1.01884580
66	MP0003698_abnormal_male_reproductive	1.00678751
67	MP0002067_abnormal_sensory_capabilities	0.99804378
68	MP0001764_abnormal_homeostasis	0.99431568
69	MP0002557_abnormal_social/conspecific_i	0.99281867
70	MP0005084_abnormal_gallbladder_morpholo	0.98461294
71	MP0003119_abnormal_digestive_system	0.97399198
72	MP0004215_abnormal_myocardial_fiber	0.96615257
73	MP0005195_abnormal_posterior_eye	0.94293937
74	MP0003635_abnormal_synaptic_transmissio	0.90756803
75	MP0002229_neurodegeneration	0.88233987
76	MP0002752_abnormal_somatic_nervous	0.86240533
77	MP0001905_abnormal_dopamine_level	0.85217436
78	MP0004085_abnormal_heartbeat	0.84872084
79	MP0000230_abnormal_systemic_arterial	0.84831167
80	MP0002733_abnormal_thermal_nociception	0.82495404
81	MP0001929_abnormal_gametogenesis	0.81104333
82	MP0005410_abnormal_fertilization	0.80900868
83	MP0002063_abnormal_learning/memory/cond	0.80388102
84	MP0001324_abnormal_eye_pigmentation	0.80370570
85	MP0009697_abnormal_copulation	0.79083928
86	MP0005075_abnormal_melanosome_morpholog	0.78524474
87	MP0000653_abnormal_sex_gland	0.77868865
88	MP0008058_abnormal_DNA_repair	0.77508423
89	MP0006035_abnormal_mitochondrial_morpho	0.76599138
90	MP0008789_abnormal_olfactory_epithelium	0.76305922
91	MP0001963_abnormal_hearing_physiology	0.75553928
92	MP0002653_abnormal_ependyma_morphology	0.73676453
93	MP0003786_premature_aging	0.73119631
94	MP0002882_abnormal_neuron_morphology	0.72626411
95	MP0004742_abnormal_vestibular_system	0.72511705
96	MP0005391_vision/eye_phenotype	0.72470931
97	MP0000955_abnormal_spinal_cord	0.71654793
98	MP0005174_abnormal_tail_pigmentation	0.71626713
99	MP0001145_abnormal_male_reproductive	0.71276443
100	MP0005395_other_phenotype	0.70788208

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.11327106
2	Abnormality of midbrain morphology (HP:0002418)	4.06838735
3	Molar tooth sign on MRI (HP:0002419)	4.06838735
4	Pancreatic fibrosis (HP:0100732)	4.03174322
5	True hermaphroditism (HP:0010459)	3.87882678
6	Nephronophthisis (HP:0000090)	3.74158008
7	Progressive inability to walk (HP:0002505)	3.51125634
8	Congenital stationary night blindness (HP:0007642)	3.48299962
9	Abnormality of the renal cortex (HP:0011035)	3.36237683
10	Abnormality of the renal medulla (HP:0100957)	3.20528508
11	Chronic hepatic failure (HP:0100626)	3.11064235
12	Medial flaring of the eyebrow (HP:0010747)	3.07002083
13	Hypothermia (HP:0002045)	3.03509198
14	Attenuation of retinal blood vessels (HP:0007843)	2.86837456
15	Hyperventilation (HP:0002883)	2.80519870
16	Thyroid-stimulating hormone excess (HP:0002925)	2.66745942
17	Cystic liver disease (HP:0006706)	2.65631010
18	Renal cortical cysts (HP:0000803)	2.65246658
19	Abolished electroretinogram (ERG) (HP:0000550)	2.65079856
20	Inability to walk (HP:0002540)	2.60238401
21	Broad-based gait (HP:0002136)	2.58828751
22	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.58611930
23	Gaze-evoked nystagmus (HP:0000640)	2.57246873
24	Tubular atrophy (HP:0000092)	2.53944184
25	Lissencephaly (HP:0001339)	2.44899220
26	Gait imbalance (HP:0002141)	2.44028744
27	Intestinal atresia (HP:0011100)	2.41764022
28	Pendular nystagmus (HP:0012043)	2.40824571
29	Congenital primary aphakia (HP:0007707)	2.40638550
30	Abnormal drinking behavior (HP:0030082)	2.40176935
31	Polydipsia (HP:0001959)	2.40176935
32	Methylmalonic acidemia (HP:0002912)	2.37833332
33	Type II lissencephaly (HP:0007260)	2.37264374
34	Pachygyria (HP:0001302)	2.35912953
35	Nephrogenic diabetes insipidus (HP:0009806)	2.31580594
36	Decreased central vision (HP:0007663)	2.27684664
37	Acute necrotizing encephalopathy (HP:0006965)	2.24725222
38	Bony spicule pigmentary retinopathy (HP:0007737)	2.23899097
39	Abnormal biliary tract physiology (HP:0012439)	2.22865024
40	Bile duct proliferation (HP:0001408)	2.22865024
41	Progressive macrocephaly (HP:0004481)	2.21340224
42	Patellar aplasia (HP:0006443)	2.21195649
43	Methylmalonic aciduria (HP:0012120)	2.20488606
44	Abnormality of macular pigmentation (HP:0008002)	2.19678560
45	Progressive cerebellar ataxia (HP:0002073)	2.18916199
46	Abnormality of the fovea (HP:0000493)	2.17778020
47	Limb dystonia (HP:0002451)	2.17105158
48	Furrowed tongue (HP:0000221)	2.15037394
49	Hepatocellular necrosis (HP:0001404)	2.13105386
50	Sclerocornea (HP:0000647)	2.13056691
51	Hypoplastic pelvis (HP:0008839)	2.12845886
52	Scotoma (HP:0000575)	2.11649908
53	Genital tract atresia (HP:0001827)	2.11138281
54	Hepatic necrosis (HP:0002605)	2.10523408
55	Hyperglycinemia (HP:0002154)	2.09100987
56	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08454995
57	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08454995
58	Congenital sensorineural hearing impairment (HP:0008527)	2.06634636
59	Male pseudohermaphroditism (HP:0000037)	2.06363218
60	Increased CSF lactate (HP:0002490)	2.05743903
61	Large for gestational age (HP:0001520)	2.04405898
62	Aplasia/Hypoplasia of the patella (HP:0006498)	2.03681796
63	Vaginal atresia (HP:0000148)	2.01989775
64	Postaxial foot polydactyly (HP:0001830)	2.01217490
65	Hypoplasia of the fovea (HP:0007750)	2.01066972
66	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.01066972
67	Congenital hepatic fibrosis (HP:0002612)	2.00960311
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.98330063
69	Acute encephalopathy (HP:0006846)	1.96618764
70	Absent speech (HP:0001344)	1.95473035
71	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94543620
72	Decreased circulating renin level (HP:0003351)	1.92550957
73	Neonatal respiratory distress (HP:0002643)	1.92384799
74	Anencephaly (HP:0002323)	1.90189654
75	Abnormality of the labia minora (HP:0012880)	1.90158275
76	Polyuria (HP:0000103)	1.87708624
77	Generalized myoclonic seizures (HP:0002123)	1.86990048
78	Cerebellar dysplasia (HP:0007033)	1.86691823
79	Mitochondrial inheritance (HP:0001427)	1.84257413
80	Generalized aminoaciduria (HP:0002909)	1.83878767
81	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83620773
82	Postaxial hand polydactyly (HP:0001162)	1.82811747
83	Ketoacidosis (HP:0001993)	1.82210330
84	Hemiparesis (HP:0001269)	1.81932786
85	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81848027
86	Optic nerve hypoplasia (HP:0000609)	1.80562898
87	Febrile seizures (HP:0002373)	1.80207646
88	Facial diplegia (HP:0001349)	1.80092708
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79886364
90	Global brain atrophy (HP:0002283)	1.78929492
91	Hypsarrhythmia (HP:0002521)	1.78799694
92	Adrenal hypoplasia (HP:0000835)	1.73433900
93	Keratoconus (HP:0000563)	1.72017958
94	Increased corneal curvature (HP:0100692)	1.72017958
95	EEG with generalized epileptiform discharges (HP:0011198)	1.71608526
96	Abnormality of vitamin B metabolism (HP:0004340)	1.69771722
97	Status epilepticus (HP:0002133)	1.69549758
98	Dandy-Walker malformation (HP:0001305)	1.68990673
99	Decreased testicular size (HP:0008734)	1.67555301
100	Chorioretinal atrophy (HP:0000533)	1.67102204

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.04730787
2	MAP4K2	3.60918311
3	CASK	3.26740425
4	WNK3	3.20099881
5	TRIM28	3.16128998
6	MAP3K4	2.74332662
7	ADRBK2	2.64916295
8	MAPK13	2.29362737
9	ERBB3	2.25313067
10	GRK1	2.06682015
11	BMPR1B	2.05572138
12	MAP2K7	2.01926731
13	PINK1	1.91122122
14	ZAK	1.77021530
15	NUAK1	1.75342213
16	BCR	1.67993726
17	DAPK2	1.57504480
18	ACVR1B	1.53312215
19	INSRR	1.48550238
20	PLK2	1.43241622
21	TNIK	1.42787719
22	SIK3	1.38670767
23	MARK1	1.28382954
24	OXSR1	1.27731446
25	STK39	1.20246254
26	DYRK2	1.18560035
27	TAOK3	1.15094094
28	TIE1	1.14740480
29	NTRK3	1.12001499
30	UHMK1	1.09121189
31	WNK4	1.08472827
32	PAK3	0.95250159
33	EPHA3	0.92136891
34	PRKCE	0.90313456
35	MKNK2	0.89640064
36	FGFR2	0.87307623
37	STK16	0.87281625
38	STK38L	0.84813664
39	YES1	0.83897676
40	TEC	0.82228488
41	ADRBK1	0.79542380
42	CSNK1G2	0.75945640
43	FER	0.74669069
44	PRKCG	0.73805803
45	CDK3	0.73636778
46	CSNK1G1	0.71137158
47	AKT3	0.70216311
48	TXK	0.69045192
49	EPHA4	0.66190792
50	MAP2K4	0.65214423
51	PLK3	0.65137864
52	CSNK1G3	0.64826031
53	TLK1	0.63005806
54	OBSCN	0.61314343
55	MINK1	0.61153911
56	DYRK1B	0.61037430
57	EIF2AK3	0.60469750
58	BCKDK	0.60218694
59	MST4	0.60156336
60	PTK2B	0.59940913
61	CAMK2A	0.59497327
62	PRKAA1	0.57465801
63	PKN1	0.57026479
64	KIT	0.56722754
65	MKNK1	0.56000484
66	FLT3	0.55043394
67	MAPKAPK3	0.54745751
68	BRSK2	0.53180697
69	CSNK1A1L	0.53023223
70	TGFBR1	0.51743572
71	TNK2	0.50710359
72	PHKG2	0.50544324
73	PHKG1	0.50544324
74	IRAK1	0.48767347
75	VRK1	0.48033682
76	MUSK	0.46736562
77	HIPK2	0.45941153
78	MAP2K6	0.44274952
79	MAP3K6	0.43803294
80	PLK4	0.43748592
81	NTRK2	0.42533679
82	ATR	0.41940629
83	PDK2	0.41914578
84	PRKACA	0.40716128
85	RPS6KA5	0.40522882
86	DYRK3	0.39797562
87	CSNK1A1	0.39667119
88	CAMK2D	0.39014193
89	STK3	0.38860915
90	PNCK	0.38190822
91	CDK6	0.37948286
92	PIK3CG	0.36836012
93	NLK	0.35893368
94	GRK7	0.35573882
95	PRKCA	0.33695257
96	PRKCQ	0.32635786
97	MAPKAPK5	0.32137800
98	ATM	0.31817104
99	MAPK8	0.31473136
100	CSNK2A1	0.28834824

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.92574944
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.48481302
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.08704488
4	Butanoate metabolism_Homo sapiens_hsa00650	2.81252093
5	Basal transcription factors_Homo sapiens_hsa03022	2.74215817
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.66036684
7	Phototransduction_Homo sapiens_hsa04744	2.44635332
8	Protein export_Homo sapiens_hsa03060	2.34380763
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.32821465
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.13189166
11	Tryptophan metabolism_Homo sapiens_hsa00380	1.99664927
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.99112579
13	Nicotine addiction_Homo sapiens_hsa05033	1.99089558
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.95754210
15	Propanoate metabolism_Homo sapiens_hsa00640	1.85214638
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.73959304
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69667233
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.64059971
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.58451129
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.53023778
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.51645680
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.51272078
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51017057
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.44660923
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.42217263
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39802910
27	Caffeine metabolism_Homo sapiens_hsa00232	1.33914792
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32947987
29	Olfactory transduction_Homo sapiens_hsa04740	1.32937183
30	Taste transduction_Homo sapiens_hsa04742	1.32805629
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28294049
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26450979
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.26090234
34	Homologous recombination_Homo sapiens_hsa03440	1.25786052
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.24861038
36	Fatty acid degradation_Homo sapiens_hsa00071	1.16698446
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13625077
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13391365
39	ABC transporters_Homo sapiens_hsa02010	1.09273907
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07484465
41	Peroxisome_Homo sapiens_hsa04146	1.06832230
42	Circadian entrainment_Homo sapiens_hsa04713	1.05945154
43	Retinol metabolism_Homo sapiens_hsa00830	1.04576026
44	RNA degradation_Homo sapiens_hsa03018	1.00964595
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.99406298
46	Parkinsons disease_Homo sapiens_hsa05012	0.98420356
47	Morphine addiction_Homo sapiens_hsa05032	0.94585135
48	Insulin secretion_Homo sapiens_hsa04911	0.90380769
49	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89176515
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87557243
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86137403
52	Histidine metabolism_Homo sapiens_hsa00340	0.82743621
53	GABAergic synapse_Homo sapiens_hsa04727	0.78647998
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.78263125
55	Salivary secretion_Homo sapiens_hsa04970	0.77584450
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76950783
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.72549014
58	RNA polymerase_Homo sapiens_hsa03020	0.71782321
59	Serotonergic synapse_Homo sapiens_hsa04726	0.70206138
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69826768
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.69234185
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.68992008
63	Metabolic pathways_Homo sapiens_hsa01100	0.67431279
64	Huntingtons disease_Homo sapiens_hsa05016	0.62508191
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.60799927
66	Regulation of autophagy_Homo sapiens_hsa04140	0.59540582
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.58878180
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58541880
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.57463809
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56561052
71	Sulfur metabolism_Homo sapiens_hsa00920	0.56240663
72	Alzheimers disease_Homo sapiens_hsa05010	0.54719666
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.54154259
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52386482
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.51016831
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48911378
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48802072
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.48125655
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47996155
80	Circadian rhythm_Homo sapiens_hsa04710	0.46783842
81	Fatty acid elongation_Homo sapiens_hsa00062	0.45720867
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44642141
83	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42508858
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.41071856
85	Amphetamine addiction_Homo sapiens_hsa05031	0.38454667
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38120666
87	Asthma_Homo sapiens_hsa05310	0.37300090
88	PPAR signaling pathway_Homo sapiens_hsa03320	0.37143471
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.36780569
90	Purine metabolism_Homo sapiens_hsa00230	0.35728616
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35385583
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34171956
93	Renin secretion_Homo sapiens_hsa04924	0.33222262
94	Gastric acid secretion_Homo sapiens_hsa04971	0.32106558
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29622220
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.27555367
97	Long-term depression_Homo sapiens_hsa04730	0.27502903
98	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.27085714
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.26609748
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26012894

ZNF429

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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