ZNF43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.29783704
2neural tube formation (GO:0001841)3.77482929
3replication fork processing (GO:0031297)3.77292466
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53854128
5chromatin remodeling at centromere (GO:0031055)3.53252886
6presynaptic membrane assembly (GO:0097105)3.52915804
7negative regulation of DNA-dependent DNA replication (GO:2000104)3.51442397
8pyrimidine nucleobase catabolic process (GO:0006208)3.44913651
9resolution of meiotic recombination intermediates (GO:0000712)3.44509589
10centriole replication (GO:0007099)3.29828450
11intraciliary transport (GO:0042073)3.27803510
12negative regulation of translation, ncRNA-mediated (GO:0040033)3.26448978
13regulation of translation, ncRNA-mediated (GO:0045974)3.26448978
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.26448978
15regulation of telomere maintenance (GO:0032204)3.26294480
16CENP-A containing nucleosome assembly (GO:0034080)3.24114967
17behavioral response to nicotine (GO:0035095)3.21352061
18epithelial cilium movement (GO:0003351)3.14266463
19somite development (GO:0061053)3.11487748
20nonmotile primary cilium assembly (GO:0035058)3.08316508
21histone exchange (GO:0043486)3.07091798
22limb bud formation (GO:0060174)3.04052311
23somite rostral/caudal axis specification (GO:0032525)3.03155085
24presynaptic membrane organization (GO:0097090)3.01936654
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.01469788
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01469788
27response to pheromone (GO:0019236)3.00498232
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00091156
29histone H2A acetylation (GO:0043968)2.98978747
30recombinational repair (GO:0000725)2.98072589
31kidney morphogenesis (GO:0060993)2.97584816
32double-strand break repair via homologous recombination (GO:0000724)2.96035097
33regulation of nuclear cell cycle DNA replication (GO:0033262)2.93980552
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93337494
35regulation of mitotic spindle checkpoint (GO:1903504)2.93337494
36cilium morphogenesis (GO:0060271)2.92062482
37protein prenylation (GO:0018342)2.89551127
38prenylation (GO:0097354)2.89551127
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88741053
40reciprocal DNA recombination (GO:0035825)2.87520840
41reciprocal meiotic recombination (GO:0007131)2.87520840
42otic vesicle formation (GO:0030916)2.86808457
43DNA replication-dependent nucleosome organization (GO:0034723)2.80273571
44DNA replication-dependent nucleosome assembly (GO:0006335)2.80273571
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79551673
46tachykinin receptor signaling pathway (GO:0007217)2.78104646
47negative regulation of telomere maintenance (GO:0032205)2.76214170
48microtubule depolymerization (GO:0007019)2.74824567
49microtubule anchoring (GO:0034453)2.73800148
50negative regulation of DNA recombination (GO:0045910)2.72690060
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72494108
52nucleobase catabolic process (GO:0046113)2.72075195
53photoreceptor cell maintenance (GO:0045494)2.71980759
54kinetochore organization (GO:0051383)2.71876331
55seminiferous tubule development (GO:0072520)2.71626153
56cilium organization (GO:0044782)2.70887134
57ncRNA catabolic process (GO:0034661)2.69506274
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69422254
59kinetochore assembly (GO:0051382)2.67505684
60regulation of centriole replication (GO:0046599)2.66591095
61cilium assembly (GO:0042384)2.66058695
62synapsis (GO:0007129)2.65062790
63meiotic chromosome segregation (GO:0045132)2.64922539
64regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61885885
65DNA replication-independent nucleosome organization (GO:0034724)2.61631911
66DNA replication-independent nucleosome assembly (GO:0006336)2.61631911
67regulation of telomere maintenance via telomerase (GO:0032210)2.60897046
68olfactory bulb development (GO:0021772)2.59406911
69cilium movement (GO:0003341)2.59235016
70spermatid nucleus differentiation (GO:0007289)2.58871053
71cilium or flagellum-dependent cell motility (GO:0001539)2.58847148
72regulation of DNA endoreduplication (GO:0032875)2.54002775
73regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53007084
74regulation of cilium movement (GO:0003352)2.52666306
75protein K6-linked ubiquitination (GO:0085020)2.51150865
76negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50634069
77forebrain neuron differentiation (GO:0021879)2.49621449
78establishment of protein localization to Golgi (GO:0072600)2.48123866
79regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.46294609
80protein localization to cilium (GO:0061512)2.46290958
81hindbrain development (GO:0030902)2.45900769
82retinal ganglion cell axon guidance (GO:0031290)2.45880687
83microtubule polymerization or depolymerization (GO:0031109)2.45702700
84regulation of helicase activity (GO:0051095)2.44642119
85fucose catabolic process (GO:0019317)2.43986194
86L-fucose metabolic process (GO:0042354)2.43986194
87L-fucose catabolic process (GO:0042355)2.43986194
88regulation of mesoderm development (GO:2000380)2.42441407
89behavioral response to ethanol (GO:0048149)2.42397380
90axoneme assembly (GO:0035082)2.41973580
91postreplication repair (GO:0006301)2.41609712
92centrosome organization (GO:0051297)2.39869407
93microtubule organizing center organization (GO:0031023)2.38922181
94attachment of spindle microtubules to kinetochore (GO:0008608)2.37591659
95DNA ligation (GO:0006266)2.36452589
96DNA topological change (GO:0006265)2.36085686
97acrosome assembly (GO:0001675)2.33800960
98DNA catabolic process, exonucleolytic (GO:0000738)2.33428822
99platelet dense granule organization (GO:0060155)2.32707420
100regulation of gene silencing by miRNA (GO:0060964)2.31901494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.54237830
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.14980335
3IGF1R_20145208_ChIP-Seq_DFB_Human2.92271664
4GBX2_23144817_ChIP-Seq_PC3_Human2.76144695
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74264399
6VDR_22108803_ChIP-Seq_LS180_Human2.68980351
7FUS_26573619_Chip-Seq_HEK293_Human2.63372790
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57152496
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56543474
10EWS_26573619_Chip-Seq_HEK293_Human2.48801875
11TAF15_26573619_Chip-Seq_HEK293_Human2.44297624
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41047621
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32534539
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26052782
15P300_19829295_ChIP-Seq_ESCs_Human2.20806784
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19135954
17EZH2_22144423_ChIP-Seq_EOC_Human2.15244367
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07844870
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.07160772
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99831641
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93997341
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87924304
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85870973
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84292730
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76351905
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75106980
27IRF1_19129219_ChIP-ChIP_H3396_Human1.70626246
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.69875311
29ELK1_19687146_ChIP-ChIP_HELA_Human1.69298968
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66978306
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.66230048
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63469862
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61051605
34ER_23166858_ChIP-Seq_MCF-7_Human1.60317724
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55797021
36* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54846105
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.54615819
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53342958
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53342958
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49889912
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.48447585
42* CBP_20019798_ChIP-Seq_JUKART_Human1.47352406
43* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47352406
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.46585299
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.46287765
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45780151
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45146642
48MYC_18940864_ChIP-ChIP_HL60_Human1.45047048
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44569008
50STAT3_23295773_ChIP-Seq_U87_Human1.39377300
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38925513
52AR_25329375_ChIP-Seq_VCAP_Human1.38357092
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37463929
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36998277
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34552199
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.34206724
57BCAT_22108803_ChIP-Seq_LS180_Human1.32982573
58RNF2_27304074_Chip-Seq_NSC_Mouse1.32648266
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28452355
60TCF4_23295773_ChIP-Seq_U87_Human1.27080474
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25269550
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24543688
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24481932
64* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24298970
65TCF4_22108803_ChIP-Seq_LS180_Human1.24256128
66RUNX2_22187159_ChIP-Seq_PCA_Human1.23271314
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.22213521
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.22006632
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.21997428
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20821063
71SOX2_19829295_ChIP-Seq_ESCs_Human1.20356623
72NANOG_19829295_ChIP-Seq_ESCs_Human1.20356623
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.18134124
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18088598
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.17984173
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16396129
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16332393
78* VDR_23849224_ChIP-Seq_CD4+_Human1.15128445
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13820253
80TP53_22573176_ChIP-Seq_HFKS_Human1.13571221
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.10897710
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09792805
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06899669
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06737547
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06670186
86P53_22387025_ChIP-Seq_ESCs_Mouse1.06580838
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.04677743
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.03945368
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03204509
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02848775
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00459627
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00268672
93E2F7_22180533_ChIP-Seq_HELA_Human1.00136720
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.99509335
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98271374
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98020546
97P300_18555785_Chip-Seq_ESCs_Mouse0.97902848
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96001212
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94942421
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94860751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.44653824
2MP0006292_abnormal_olfactory_placode2.92653936
3MP0003890_abnormal_embryonic-extraembry2.76370274
4MP0003787_abnormal_imprinting2.63180675
5MP0003880_abnormal_central_pattern2.58928679
6MP0003136_yellow_coat_color2.54999067
7MP0008058_abnormal_DNA_repair2.48122510
8MP0002102_abnormal_ear_morphology2.43488902
9MP0004133_heterotaxia2.31381023
10MP0003121_genomic_imprinting2.22113613
11MP0002938_white_spotting2.20711274
12MP0008057_abnormal_DNA_replication2.12942971
13MP0008789_abnormal_olfactory_epithelium2.07283589
14MP0001529_abnormal_vocalization2.02608991
15MP0006072_abnormal_retinal_apoptosis2.01147159
16MP0010094_abnormal_chromosome_stability1.97269369
17MP0000569_abnormal_digit_pigmentation1.80368853
18MP0005394_taste/olfaction_phenotype1.78810513
19MP0005499_abnormal_olfactory_system1.78810513
20MP0006276_abnormal_autonomic_nervous1.77388172
21MP0005551_abnormal_eye_electrophysiolog1.77138494
22MP0001984_abnormal_olfaction1.76420528
23MP0001293_anophthalmia1.74704585
24MP0000778_abnormal_nervous_system1.73489564
25MP0003122_maternal_imprinting1.72011293
26MP0003195_calcinosis1.69444104
27MP0000631_abnormal_neuroendocrine_gland1.63073187
28MP0002751_abnormal_autonomic_nervous1.61384709
29MP0005253_abnormal_eye_physiology1.61176143
30MP0003119_abnormal_digestive_system1.60266822
31MP0002638_abnormal_pupillary_reflex1.56786408
32MP0003937_abnormal_limbs/digits/tail_de1.54642844
33MP0002653_abnormal_ependyma_morphology1.49537269
34MP0001486_abnormal_startle_reflex1.48724755
35MP0001485_abnormal_pinna_reflex1.46712290
36MP0003567_abnormal_fetal_cardiomyocyte1.40777990
37MP0000427_abnormal_hair_cycle1.37914599
38MP0001968_abnormal_touch/_nociception1.37896736
39MP0002736_abnormal_nociception_after1.37307140
40MP0002234_abnormal_pharynx_morphology1.35685331
41MP0005646_abnormal_pituitary_gland1.32608690
42MP0010386_abnormal_urinary_bladder1.30419492
43MP0001188_hyperpigmentation1.24530611
44MP0002233_abnormal_nose_morphology1.19670166
45MP0000383_abnormal_hair_follicle1.17954218
46MP0003693_abnormal_embryo_hatching1.14705183
47MP0000049_abnormal_middle_ear1.12686961
48MP0008995_early_reproductive_senescence1.11378811
49MP0004142_abnormal_muscle_tone1.10849669
50MP0000566_synostosis1.10313633
51MP0002837_dystrophic_cardiac_calcinosis1.08893915
52MP0001286_abnormal_eye_development1.08886944
53MP0009745_abnormal_behavioral_response1.08731064
54MP0004147_increased_porphyrin_level1.08555442
55MP0002272_abnormal_nervous_system1.08536737
56MP0004885_abnormal_endolymph1.07499362
57MP0003718_maternal_effect1.07410124
58MP0000647_abnormal_sebaceous_gland1.06324515
59MP0000372_irregular_coat_pigmentation1.05642631
60MP0005645_abnormal_hypothalamus_physiol1.05448147
61MP0005195_abnormal_posterior_eye1.04415135
62MP0001929_abnormal_gametogenesis1.04206866
63MP0002735_abnormal_chemical_nociception1.04102582
64MP0002210_abnormal_sex_determination1.03266102
65MP0005391_vision/eye_phenotype1.00507203
66MP0005084_abnormal_gallbladder_morpholo0.99787323
67MP0002184_abnormal_innervation0.98555278
68MP0008872_abnormal_physiological_respon0.97754799
69MP0005367_renal/urinary_system_phenotyp0.97677968
70MP0000516_abnormal_urinary_system0.97677968
71MP0003698_abnormal_male_reproductive0.97563306
72MP0002752_abnormal_somatic_nervous0.97358396
73MP0002557_abnormal_social/conspecific_i0.97231164
74MP0009046_muscle_twitch0.96691017
75MP0003011_delayed_dark_adaptation0.95212230
76MP0001986_abnormal_taste_sensitivity0.94460139
77MP0005187_abnormal_penis_morphology0.94315682
78MP0000653_abnormal_sex_gland0.93179930
79MP0003861_abnormal_nervous_system0.92783097
80MP0001145_abnormal_male_reproductive0.92034056
81MP0002160_abnormal_reproductive_system0.91677010
82MP0003646_muscle_fatigue0.90806121
83MP0002572_abnormal_emotion/affect_behav0.86132305
84MP0002254_reproductive_system_inflammat0.84217583
85MP0000955_abnormal_spinal_cord0.83749766
86MP0009697_abnormal_copulation0.81326444
87MP0004924_abnormal_behavior0.80992672
88MP0005386_behavior/neurological_phenoty0.80992672
89MP0003755_abnormal_palate_morphology0.80487044
90MP0005389_reproductive_system_phenotype0.79166101
91MP0004742_abnormal_vestibular_system0.79027281
92MP0004215_abnormal_myocardial_fiber0.78776488
93MP0002095_abnormal_skin_pigmentation0.78311612
94MP0003111_abnormal_nucleus_morphology0.77879715
95MP0003077_abnormal_cell_cycle0.77392209
96MP0002152_abnormal_brain_morphology0.76869400
97MP0000026_abnormal_inner_ear0.75604682
98MP0004043_abnormal_pH_regulation0.75520872
99MP0002928_abnormal_bile_duct0.75330533
100MP0003786_premature_aging0.75274045

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.77772821
2True hermaphroditism (HP:0010459)3.67520395
3Pancreatic fibrosis (HP:0100732)3.59368079
4Abnormality of the labia minora (HP:0012880)3.49642220
5Molar tooth sign on MRI (HP:0002419)3.32167334
6Abnormality of midbrain morphology (HP:0002418)3.32167334
7Nephronophthisis (HP:0000090)3.22662738
8Colon cancer (HP:0003003)3.08386673
9Intestinal atresia (HP:0011100)3.01323904
10Medial flaring of the eyebrow (HP:0010747)2.98162368
11Volvulus (HP:0002580)2.90272774
12Abnormality of the renal medulla (HP:0100957)2.82663291
13Chronic hepatic failure (HP:0100626)2.63952184
14Abnormality of the ileum (HP:0001549)2.60732437
15Gait imbalance (HP:0002141)2.60057953
16Congenital primary aphakia (HP:0007707)2.58649875
17Meckel diverticulum (HP:0002245)2.54790336
18Genital tract atresia (HP:0001827)2.53194618
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.52959998
20Hyperventilation (HP:0002883)2.50923966
21Vaginal atresia (HP:0000148)2.46164850
22Abnormality of the renal cortex (HP:0011035)2.46004467
23Aplasia/Hypoplasia of the tibia (HP:0005772)2.44351357
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.38833460
25Nephrogenic diabetes insipidus (HP:0009806)2.37094923
26Septo-optic dysplasia (HP:0100842)2.34173109
27Optic nerve hypoplasia (HP:0000609)2.32017435
28Pendular nystagmus (HP:0012043)2.28954217
29Abnormality of chromosome stability (HP:0003220)2.28560574
30Cystic liver disease (HP:0006706)2.25363772
31Congenital stationary night blindness (HP:0007642)2.25257589
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21681683
33Postaxial foot polydactyly (HP:0001830)2.20823163
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20804352
35Broad-based gait (HP:0002136)2.17881935
36Abolished electroretinogram (ERG) (HP:0000550)2.17564183
37Sclerocornea (HP:0000647)2.15227260
38Chromsome breakage (HP:0040012)2.14726039
39Gastrointestinal atresia (HP:0002589)2.08117793
40Short tibia (HP:0005736)2.07529393
41Anencephaly (HP:0002323)2.06756411
42Supernumerary spleens (HP:0009799)2.03496963
43Tubular atrophy (HP:0000092)2.01869701
44Preaxial hand polydactyly (HP:0001177)2.01839687
45Postaxial hand polydactyly (HP:0001162)2.01409700
46Abnormal biliary tract physiology (HP:0012439)1.98470070
47Bile duct proliferation (HP:0001408)1.98470070
48Type II lissencephaly (HP:0007260)1.97804681
49Sloping forehead (HP:0000340)1.97781981
50Patellar aplasia (HP:0006443)1.97673886
51Abnormal lung lobation (HP:0002101)1.96879738
52Lissencephaly (HP:0001339)1.96865368
53Oligodactyly (hands) (HP:0001180)1.95203107
54Poor coordination (HP:0002370)1.93846691
55Renal cortical cysts (HP:0000803)1.92932967
56Hyperglycinemia (HP:0002154)1.91286530
57Abnormality of the duodenum (HP:0002246)1.89676665
58Dandy-Walker malformation (HP:0001305)1.89611707
59Congenital hepatic fibrosis (HP:0002612)1.87301903
60Male pseudohermaphroditism (HP:0000037)1.85055721
61Cerebellar dysplasia (HP:0007033)1.84286562
62Hyperglycinuria (HP:0003108)1.83751682
63Astigmatism (HP:0000483)1.83239388
64Narrow forehead (HP:0000341)1.82865071
65Small intestinal stenosis (HP:0012848)1.82861520
66Duodenal stenosis (HP:0100867)1.82861520
67Progressive inability to walk (HP:0002505)1.82342701
68Triphalangeal thumb (HP:0001199)1.82228170
69Anophthalmia (HP:0000528)1.82040331
70Birth length less than 3rd percentile (HP:0003561)1.81903576
71Aqueductal stenosis (HP:0002410)1.81902234
72Aplasia/Hypoplasia of the patella (HP:0006498)1.81732583
73Thyroiditis (HP:0100646)1.80986573
74Methylmalonic acidemia (HP:0002912)1.80841040
75Tubulointerstitial nephritis (HP:0001970)1.79495736
76Drooling (HP:0002307)1.78713208
77Attenuation of retinal blood vessels (HP:0007843)1.76324283
78Bilateral microphthalmos (HP:0007633)1.75518966
79Ectopic kidney (HP:0000086)1.75417570
80Renal hypoplasia (HP:0000089)1.74497733
81Hypoplasia of the pons (HP:0012110)1.74188332
82Nephroblastoma (Wilms tumor) (HP:0002667)1.74087647
83Abnormality of the preputium (HP:0100587)1.73468595
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.72256459
85Absent radius (HP:0003974)1.72080707
86Broad foot (HP:0001769)1.71936714
87Abnormality of the pons (HP:0007361)1.71499300
88Hip dysplasia (HP:0001385)1.71278063
89Small hand (HP:0200055)1.70972295
90Embryonal renal neoplasm (HP:0011794)1.70806668
91Clubbing of toes (HP:0100760)1.69524239
92Abnormal rod and cone electroretinograms (HP:0008323)1.69094413
93Bifid tongue (HP:0010297)1.68858373
94Rib fusion (HP:0000902)1.68703977
95Inability to walk (HP:0002540)1.68670000
96Absent forearm bone (HP:0003953)1.68594009
97Aplasia involving forearm bones (HP:0009822)1.68594009
98Hepatoblastoma (HP:0002884)1.67969122
99Neoplasm of the adrenal cortex (HP:0100641)1.67429997
100Aganglionic megacolon (HP:0002251)1.65844422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.05396069
2WNK33.35795625
3MAP4K23.21957926
4TRIM282.83111210
5BMPR1B2.65301584
6MKNK22.57259558
7ZAK2.50557578
8NUAK12.36073233
9MAP3K42.23375540
10ACVR1B2.11643305
11PLK42.08962426
12MKNK12.05908557
13CASK1.94868466
14TNIK1.87032691
15PINK11.76937010
16BCR1.72584443
17MAPK131.62545034
18SRPK11.61554038
19CDC71.59688216
20MAP2K71.57291765
21VRK11.51452126
22WEE11.50631436
23BUB11.47357117
24ADRBK21.46649915
25PLK31.46312074
26ERBB31.45716795
27BRSK21.43206128
28EPHA41.40520031
29GRK11.33583116
30DYRK21.33021439
31PNCK1.30467973
32DYRK31.30390293
33STK38L1.25643430
34FGFR21.23628417
35TTK1.19157913
36TGFBR11.14748128
37EIF2AK31.11684590
38NLK1.10275928
39CSNK1G11.09758785
40MARK11.07087845
41INSRR1.03932747
42OXSR11.00741506
43CSNK1G20.99825452
44PLK10.99822660
45PLK20.96576487
46STK390.94946284
47TAF10.92063437
48CSNK1G30.88641284
49WNK40.88037594
50PAK30.87934349
51BRD40.85888568
52TSSK60.85073788
53NEK10.84195920
54PRKCG0.83350251
55ATR0.79225300
56TLK10.77006907
57PBK0.74905821
58VRK20.73783170
59STK30.73088620
60CSNK1A1L0.72026192
61PRKCE0.70681008
62NEK20.68890100
63CDK190.68697463
64FLT30.66194468
65CDK30.65556835
66CHEK20.64468828
67ATM0.63052760
68EIF2AK20.62465939
69LATS10.61760049
70RPS6KA40.60014497
71DYRK1A0.56037612
72MINK10.55065591
73NTRK30.53721570
74NTRK20.53094222
75PIK3CA0.48951336
76CCNB10.46727698
77BCKDK0.46586259
78STK160.45208977
79ADRBK10.45030383
80MAP2K40.42583612
81SGK20.40885611
82TAOK30.38420587
83AURKB0.37671495
84STK110.37526175
85TEC0.37113505
86MAP3K100.35817889
87CSNK1A10.34553134
88TIE10.34192450
89CDK10.32920651
90CSNK1D0.31988218
91PKN10.31963350
92UHMK10.31375218
93MST40.31222152
94CSNK1E0.30595161
95FGFR10.30305761
96PRKACB0.30254220
97SGK2230.30126350
98SGK4940.30126350
99PRKDC0.29714196
100OBSCN0.29482996

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.37540466
2Fanconi anemia pathway_Homo sapiens_hsa034603.15200150
3Homologous recombination_Homo sapiens_hsa034403.00541141
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76479753
5Phototransduction_Homo sapiens_hsa047442.39461593
6Mismatch repair_Homo sapiens_hsa034302.36225744
7Basal transcription factors_Homo sapiens_hsa030222.28415269
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16939024
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07700262
10Protein export_Homo sapiens_hsa030602.06043368
11RNA degradation_Homo sapiens_hsa030182.04812861
12Propanoate metabolism_Homo sapiens_hsa006402.02178167
13Nicotine addiction_Homo sapiens_hsa050332.00944835
14Butanoate metabolism_Homo sapiens_hsa006502.00517252
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94341516
16Linoleic acid metabolism_Homo sapiens_hsa005911.68816739
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67075625
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65463397
19Steroid biosynthesis_Homo sapiens_hsa001001.63441976
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61147178
21Selenocompound metabolism_Homo sapiens_hsa004501.59674568
22DNA replication_Homo sapiens_hsa030301.55836962
23RNA polymerase_Homo sapiens_hsa030201.54307568
24Base excision repair_Homo sapiens_hsa034101.52042059
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46365722
26Nucleotide excision repair_Homo sapiens_hsa034201.45350648
27RNA transport_Homo sapiens_hsa030131.43987591
28Caffeine metabolism_Homo sapiens_hsa002321.43775974
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42461811
30Taste transduction_Homo sapiens_hsa047421.38152515
31Nitrogen metabolism_Homo sapiens_hsa009101.32447214
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29153442
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27299171
34Ether lipid metabolism_Homo sapiens_hsa005651.26437338
35Oxidative phosphorylation_Homo sapiens_hsa001901.24255367
36Cell cycle_Homo sapiens_hsa041101.21129412
37Basal cell carcinoma_Homo sapiens_hsa052171.18874843
38Olfactory transduction_Homo sapiens_hsa047401.17519006
39Spliceosome_Homo sapiens_hsa030401.13250898
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07661863
41Tryptophan metabolism_Homo sapiens_hsa003801.07578113
42Peroxisome_Homo sapiens_hsa041461.07267653
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.06891301
44Regulation of autophagy_Homo sapiens_hsa041401.04821171
45Parkinsons disease_Homo sapiens_hsa050121.02807483
46Hedgehog signaling pathway_Homo sapiens_hsa043401.01572901
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.01385684
48mRNA surveillance pathway_Homo sapiens_hsa030151.00250549
49Huntingtons disease_Homo sapiens_hsa050160.93725168
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93603579
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90845743
52Proteasome_Homo sapiens_hsa030500.90141945
53One carbon pool by folate_Homo sapiens_hsa006700.88362178
54Oocyte meiosis_Homo sapiens_hsa041140.87073120
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.86656144
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86491576
57TGF-beta signaling pathway_Homo sapiens_hsa043500.80907172
58Purine metabolism_Homo sapiens_hsa002300.80650476
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.78858061
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78254717
61Retinol metabolism_Homo sapiens_hsa008300.77756101
62Glutamatergic synapse_Homo sapiens_hsa047240.77372300
63p53 signaling pathway_Homo sapiens_hsa041150.77263258
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76639253
65Hippo signaling pathway_Homo sapiens_hsa043900.76453542
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75408186
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74009162
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71110106
69Chemical carcinogenesis_Homo sapiens_hsa052040.71090166
70Morphine addiction_Homo sapiens_hsa050320.68962629
71Circadian entrainment_Homo sapiens_hsa047130.68515302
72GABAergic synapse_Homo sapiens_hsa047270.66545280
73Lysine degradation_Homo sapiens_hsa003100.63581499
74Pyrimidine metabolism_Homo sapiens_hsa002400.63298029
75Wnt signaling pathway_Homo sapiens_hsa043100.61816697
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59004976
77beta-Alanine metabolism_Homo sapiens_hsa004100.58671710
78Serotonergic synapse_Homo sapiens_hsa047260.57556530
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57399310
80Circadian rhythm_Homo sapiens_hsa047100.55807106
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55426059
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55323664
83Dopaminergic synapse_Homo sapiens_hsa047280.55197674
84Metabolic pathways_Homo sapiens_hsa011000.53410541
85Fatty acid metabolism_Homo sapiens_hsa012120.50658410
86Fatty acid elongation_Homo sapiens_hsa000620.50106718
87ABC transporters_Homo sapiens_hsa020100.49164996
88Arachidonic acid metabolism_Homo sapiens_hsa005900.48355154
89Axon guidance_Homo sapiens_hsa043600.48116446
90Fat digestion and absorption_Homo sapiens_hsa049750.46323064
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46074823
92Alzheimers disease_Homo sapiens_hsa050100.45696194
93Fatty acid degradation_Homo sapiens_hsa000710.45675666
94Cardiac muscle contraction_Homo sapiens_hsa042600.45462150
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43965979
96Long-term depression_Homo sapiens_hsa047300.43384284
97Alcoholism_Homo sapiens_hsa050340.42736132
98Insulin secretion_Homo sapiens_hsa049110.39897280
99Salivary secretion_Homo sapiens_hsa049700.39659313
100Glycerolipid metabolism_Homo sapiens_hsa005610.37124218

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