ZNF430

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.60379321
2L-fucose catabolic process (GO:0042355)4.54179499
3fucose catabolic process (GO:0019317)4.54179499
4L-fucose metabolic process (GO:0042354)4.54179499
5behavioral response to nicotine (GO:0035095)4.36462002
6neural tube formation (GO:0001841)4.11089403
7DNA double-strand break processing (GO:0000729)3.65261795
8negative regulation of telomere maintenance (GO:0032205)3.42198868
9negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.39835331
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.39835331
11regulation of translation, ncRNA-mediated (GO:0045974)3.39835331
12response to pheromone (GO:0019236)3.36097792
13replication fork processing (GO:0031297)3.35447808
14indolalkylamine metabolic process (GO:0006586)3.34295211
15axoneme assembly (GO:0035082)3.27559758
16indole-containing compound catabolic process (GO:0042436)3.27396092
17indolalkylamine catabolic process (GO:0046218)3.27396092
18tryptophan catabolic process (GO:0006569)3.27396092
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.23529389
20protein K11-linked deubiquitination (GO:0035871)3.20678487
21piRNA metabolic process (GO:0034587)3.14857158
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.09725058
23tryptophan metabolic process (GO:0006568)3.09284138
24cytochrome complex assembly (GO:0017004)3.06446967
25regulation of telomere maintenance (GO:0032204)3.06143532
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01780953
27protein complex biogenesis (GO:0070271)3.01142737
28respiratory chain complex IV assembly (GO:0008535)3.00884459
29water-soluble vitamin biosynthetic process (GO:0042364)3.00748848
30kynurenine metabolic process (GO:0070189)2.98703886
31preassembly of GPI anchor in ER membrane (GO:0016254)2.98155311
32kidney morphogenesis (GO:0060993)2.94927512
33recombinational repair (GO:0000725)2.92647611
34double-strand break repair via homologous recombination (GO:0000724)2.91002230
35centriole replication (GO:0007099)2.89160726
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86873344
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85819032
38protein-cofactor linkage (GO:0018065)2.81496221
39somite rostral/caudal axis specification (GO:0032525)2.81472114
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80861607
41mitochondrial respiratory chain complex assembly (GO:0033108)2.80737892
42platelet dense granule organization (GO:0060155)2.78731374
43reciprocal meiotic recombination (GO:0007131)2.78540146
44reciprocal DNA recombination (GO:0035825)2.78540146
45epithelial cilium movement (GO:0003351)2.76577471
46DNA demethylation (GO:0080111)2.76454288
47negative regulation of mast cell activation (GO:0033004)2.73560212
48regulation of nuclear cell cycle DNA replication (GO:0033262)2.73150433
49protein polyglutamylation (GO:0018095)2.73067536
50regulation of mesoderm development (GO:2000380)2.69269405
51signal peptide processing (GO:0006465)2.67556270
52NADH dehydrogenase complex assembly (GO:0010257)2.66014213
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66014213
54mitochondrial respiratory chain complex I assembly (GO:0032981)2.66014213
55maturation of 5.8S rRNA (GO:0000460)2.65405524
56sulfation (GO:0051923)2.65318788
57establishment of protein localization to mitochondrial membrane (GO:0090151)2.64811833
58protein localization to cilium (GO:0061512)2.64756394
59adaptation of signaling pathway (GO:0023058)2.60597352
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59190517
61cilium morphogenesis (GO:0060271)2.57597426
62protein K6-linked ubiquitination (GO:0085020)2.51946501
63detection of light stimulus involved in sensory perception (GO:0050962)2.51906927
64detection of light stimulus involved in visual perception (GO:0050908)2.51906927
65pyrimidine nucleobase catabolic process (GO:0006208)2.50985734
66regulation of memory T cell differentiation (GO:0043380)2.50320879
67reflex (GO:0060004)2.49428072
68positive regulation of oligodendrocyte differentiation (GO:0048714)2.49341647
69mannosylation (GO:0097502)2.48675014
70positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.48377691
71retinal cone cell development (GO:0046549)2.47036934
72cellular ketone body metabolic process (GO:0046950)2.45936545
73negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45675002
74GPI anchor metabolic process (GO:0006505)2.45537447
75regulation of glucokinase activity (GO:0033131)2.44276203
76regulation of hexokinase activity (GO:1903299)2.44276203
77embryonic epithelial tube formation (GO:0001838)2.43483579
78behavioral response to ethanol (GO:0048149)2.41987087
79rRNA catabolic process (GO:0016075)2.41907458
80neuronal action potential (GO:0019228)2.41782617
81activated T cell proliferation (GO:0050798)2.41641114
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.41374414
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.41374414
84establishment of protein localization to Golgi (GO:0072600)2.38595300
85positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.36798275
86regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.36798275
87cAMP catabolic process (GO:0006198)2.36642422
88positive regulation of mRNA catabolic process (GO:0061014)2.36581549
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.35489364
90regulation of mitotic spindle checkpoint (GO:1903504)2.35489364
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.34842267
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.34842267
93cilium organization (GO:0044782)2.34189045
94positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.33807394
95regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.33807394
96indole-containing compound metabolic process (GO:0042430)2.33665965
97regulation of hippo signaling (GO:0035330)2.32684629
98gamma-aminobutyric acid transport (GO:0015812)2.31819210
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.31585925
100DNA integration (GO:0015074)2.31299066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.56744784
2VDR_22108803_ChIP-Seq_LS180_Human3.11316946
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74148361
4GBX2_23144817_ChIP-Seq_PC3_Human2.74062215
5IGF1R_20145208_ChIP-Seq_DFB_Human2.66472591
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63076575
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.58678731
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57038079
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.50537918
10FUS_26573619_Chip-Seq_HEK293_Human2.40901548
11EWS_26573619_Chip-Seq_HEK293_Human2.35386840
12TAF15_26573619_Chip-Seq_HEK293_Human2.31563126
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23093276
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21841931
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19368600
16P300_19829295_ChIP-Seq_ESCs_Human2.11998557
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08782667
18* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07927489
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04798072
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.99337919
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99185662
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96990018
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93954406
24ER_23166858_ChIP-Seq_MCF-7_Human1.86914369
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.76723562
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.71833109
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68963349
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66752250
29IRF1_19129219_ChIP-ChIP_H3396_Human1.65877726
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60492145
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58311596
32ELK1_19687146_ChIP-ChIP_HELA_Human1.57562821
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55425250
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53884881
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53018559
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.53007096
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52283166
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52089513
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.50308489
40SMAD4_21799915_ChIP-Seq_A2780_Human1.49186323
41STAT3_23295773_ChIP-Seq_U87_Human1.46129466
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44894867
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44894867
44CBP_20019798_ChIP-Seq_JUKART_Human1.44453653
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44453653
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43252553
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.42775233
48EZH2_22144423_ChIP-Seq_EOC_Human1.42117759
49VDR_23849224_ChIP-Seq_CD4+_Human1.41821811
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40015061
51BCAT_22108803_ChIP-Seq_LS180_Human1.39600345
52* MYC_18940864_ChIP-ChIP_HL60_Human1.33704135
53AR_25329375_ChIP-Seq_VCAP_Human1.33288468
54TCF4_23295773_ChIP-Seq_U87_Human1.33002666
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32217553
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31385620
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30106529
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30050559
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29952681
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.29525112
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29074903
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27993685
63TP53_22573176_ChIP-Seq_HFKS_Human1.26767556
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.25827005
65NANOG_19829295_ChIP-Seq_ESCs_Human1.25598887
66SOX2_19829295_ChIP-Seq_ESCs_Human1.25598887
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25429259
68RNF2_27304074_Chip-Seq_NSC_Mouse1.24243154
69P53_22387025_ChIP-Seq_ESCs_Mouse1.23196491
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23163747
71TCF4_22108803_ChIP-Seq_LS180_Human1.23025323
72* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21900516
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19291166
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18281284
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.18281284
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.18218297
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.17546310
78AR_21572438_ChIP-Seq_LNCaP_Human1.17346740
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.16938841
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.16193414
81RUNX2_22187159_ChIP-Seq_PCA_Human1.16072004
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.14109226
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13703533
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.12417802
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12391341
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10982470
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07530201
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.07198341
89P300_18555785_Chip-Seq_ESCs_Mouse1.06172046
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05579879
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05185180
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.03644012
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.03540606
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02977085
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02695054
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02196653
97CDX2_22108803_ChIP-Seq_LS180_Human1.01930918
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01883127
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98882678
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97996871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.30998553
2MP0000569_abnormal_digit_pigmentation3.03721835
3MP0002102_abnormal_ear_morphology2.70575734
4MP0003195_calcinosis2.67564473
5MP0003787_abnormal_imprinting2.59938475
6MP0003646_muscle_fatigue2.47871737
7MP0000372_irregular_coat_pigmentation2.41014205
8MP0006292_abnormal_olfactory_placode2.30638157
9MP0006072_abnormal_retinal_apoptosis2.17619707
10MP0008057_abnormal_DNA_replication2.16442046
11MP0005253_abnormal_eye_physiology1.94356164
12MP0005551_abnormal_eye_electrophysiolog1.92860702
13MP0001986_abnormal_taste_sensitivity1.91506543
14MP0001968_abnormal_touch/_nociception1.89818243
15MP0004142_abnormal_muscle_tone1.83767182
16MP0002638_abnormal_pupillary_reflex1.81819762
17MP0000427_abnormal_hair_cycle1.81378443
18MP0008058_abnormal_DNA_repair1.80057553
19MP0003880_abnormal_central_pattern1.74490444
20MP0002938_white_spotting1.71466091
21MP0005075_abnormal_melanosome_morpholog1.68841778
22MP0009046_muscle_twitch1.68125601
23MP0002736_abnormal_nociception_after1.67457248
24MP0002837_dystrophic_cardiac_calcinosis1.65887436
25MP0005645_abnormal_hypothalamus_physiol1.63584540
26MP0008872_abnormal_physiological_respon1.58690964
27MP0004043_abnormal_pH_regulation1.57977969
28MP0003136_yellow_coat_color1.54400798
29MP0002234_abnormal_pharynx_morphology1.53630898
30MP0004885_abnormal_endolymph1.48740114
31MP0009745_abnormal_behavioral_response1.48299644
32MP0005084_abnormal_gallbladder_morpholo1.47649273
33MP0004133_heterotaxia1.43079172
34MP0003121_genomic_imprinting1.41762869
35MP0000631_abnormal_neuroendocrine_gland1.41482227
36MP0002653_abnormal_ependyma_morphology1.41343549
37MP0002163_abnormal_gland_morphology1.37287976
38MP0006276_abnormal_autonomic_nervous1.35818398
39MP0008995_early_reproductive_senescence1.35076117
40MP0002277_abnormal_respiratory_mucosa1.31824169
41MP0003890_abnormal_embryonic-extraembry1.31326310
42MP0005646_abnormal_pituitary_gland1.30056864
43MP0002272_abnormal_nervous_system1.29828217
44MP0003011_delayed_dark_adaptation1.21366603
45MP0000383_abnormal_hair_follicle1.21206073
46MP0001486_abnormal_startle_reflex1.20945581
47MP0002735_abnormal_chemical_nociception1.19972607
48MP0005379_endocrine/exocrine_gland_phen1.19710356
49MP0002876_abnormal_thyroid_physiology1.18263301
50MP0005174_abnormal_tail_pigmentation1.17653904
51MP0001529_abnormal_vocalization1.16283368
52MP0002928_abnormal_bile_duct1.14496026
53MP0001501_abnormal_sleep_pattern1.14125899
54MP0008875_abnormal_xenobiotic_pharmacok1.13359324
55MP0005389_reproductive_system_phenotype1.11611954
56MP0002095_abnormal_skin_pigmentation1.11504279
57MP0001984_abnormal_olfaction1.10486827
58MP0004742_abnormal_vestibular_system1.08834305
59MP0002751_abnormal_autonomic_nervous1.07842571
60MP0004147_increased_porphyrin_level1.07738943
61MP0005671_abnormal_response_to1.07008485
62MP0001485_abnormal_pinna_reflex1.04284398
63MP0003786_premature_aging1.02144573
64MP0010094_abnormal_chromosome_stability0.98863157
65MP0005386_behavior/neurological_phenoty0.98792502
66MP0004924_abnormal_behavior0.98792502
67MP0001919_abnormal_reproductive_system0.96595050
68MP0002557_abnormal_social/conspecific_i0.96041774
69MP0004145_abnormal_muscle_electrophysio0.94410383
70MP0002067_abnormal_sensory_capabilities0.92535041
71MP0002572_abnormal_emotion/affect_behav0.92439011
72MP0003567_abnormal_fetal_cardiomyocyte0.91608731
73MP0002160_abnormal_reproductive_system0.90884265
74MP0003718_maternal_effect0.88315008
75MP0001188_hyperpigmentation0.87477059
76MP0001929_abnormal_gametogenesis0.86910449
77MP0000647_abnormal_sebaceous_gland0.86192372
78MP0001970_abnormal_pain_threshold0.84154642
79MP0002210_abnormal_sex_determination0.83022951
80MP0003698_abnormal_male_reproductive0.82879378
81MP0002138_abnormal_hepatobiliary_system0.82742070
82MP0005195_abnormal_posterior_eye0.81517122
83MP0005410_abnormal_fertilization0.80686514
84MP0000653_abnormal_sex_gland0.79045500
85MP0010386_abnormal_urinary_bladder0.78973530
86MP0002693_abnormal_pancreas_physiology0.77637644
87MP0002064_seizures0.76711228
88MP0002733_abnormal_thermal_nociception0.76140126
89MP0003119_abnormal_digestive_system0.75978771
90MP0008961_abnormal_basal_metabolism0.75370308
91MP0009697_abnormal_copulation0.74805663
92MP0001764_abnormal_homeostasis0.74691529
93MP0006035_abnormal_mitochondrial_morpho0.74311111
94MP0001145_abnormal_male_reproductive0.73240497
95MP0005367_renal/urinary_system_phenotyp0.72497493
96MP0000516_abnormal_urinary_system0.72497493
97MP0003122_maternal_imprinting0.72100312
98MP0002752_abnormal_somatic_nervous0.71811533
99MP0005391_vision/eye_phenotype0.71491299
100MP0003137_abnormal_impulse_conducting0.70782903

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.17382944
2Pancreatic fibrosis (HP:0100732)3.75886706
3True hermaphroditism (HP:0010459)3.56185167
4Abnormality of midbrain morphology (HP:0002418)3.47632865
5Molar tooth sign on MRI (HP:0002419)3.47632865
6Hyperventilation (HP:0002883)3.41194129
7Nephronophthisis (HP:0000090)3.19973433
8Abnormality of the renal cortex (HP:0011035)3.18696216
9Congenital stationary night blindness (HP:0007642)3.16617026
10Medial flaring of the eyebrow (HP:0010747)2.91012105
11Abnormality of the renal medulla (HP:0100957)2.89030864
12Abolished electroretinogram (ERG) (HP:0000550)2.80594248
13Chronic hepatic failure (HP:0100626)2.79428131
14Type II lissencephaly (HP:0007260)2.77446816
15Renal cortical cysts (HP:0000803)2.67978202
16Genetic anticipation (HP:0003743)2.49155184
17Attenuation of retinal blood vessels (HP:0007843)2.47858295
18Gaze-evoked nystagmus (HP:0000640)2.46886838
19Pendular nystagmus (HP:0012043)2.35829436
20Hypothermia (HP:0002045)2.34998360
21Abnormality of the labia minora (HP:0012880)2.32164272
22Progressive cerebellar ataxia (HP:0002073)2.31490639
23Stomach cancer (HP:0012126)2.26379611
24Aplasia/Hypoplasia of the tibia (HP:0005772)2.22759203
25Broad-based gait (HP:0002136)2.22425009
26Birth length less than 3rd percentile (HP:0003561)2.22186701
27Cystic liver disease (HP:0006706)2.21811764
28Gait imbalance (HP:0002141)2.18287933
29Congenital primary aphakia (HP:0007707)2.18188876
30Abnormality of alanine metabolism (HP:0010916)2.14166358
31Hyperalaninemia (HP:0003348)2.14166358
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14166358
33Methylmalonic acidemia (HP:0002912)2.10740075
34Lissencephaly (HP:0001339)2.08874147
35Volvulus (HP:0002580)2.07814077
36Congenital, generalized hypertrichosis (HP:0004540)2.07253339
37Thyroiditis (HP:0100646)2.06989125
38Cerebellar dysplasia (HP:0007033)2.06626349
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.04479436
40Large for gestational age (HP:0001520)2.03410674
41Sclerocornea (HP:0000647)2.03165041
42Abnormality of the pons (HP:0007361)2.03070982
43Nephrogenic diabetes insipidus (HP:0009806)2.02210972
44Tubular atrophy (HP:0000092)2.00364999
45Febrile seizures (HP:0002373)2.00055554
46Genital tract atresia (HP:0001827)1.99773906
47Inability to walk (HP:0002540)1.99736617
48Colon cancer (HP:0003003)1.97975673
49Abnormal biliary tract physiology (HP:0012439)1.96807864
50Bile duct proliferation (HP:0001408)1.96807864
51Pachygyria (HP:0001302)1.96240378
52Aplasia/Hypoplasia of the uvula (HP:0010293)1.95940919
53Hypoplasia of the pons (HP:0012110)1.95249659
54Abnormal rod and cone electroretinograms (HP:0008323)1.93307313
55Patellar aplasia (HP:0006443)1.93187459
56Anencephaly (HP:0002323)1.92768017
57Furrowed tongue (HP:0000221)1.90958933
58Fair hair (HP:0002286)1.90882478
59Abnormal drinking behavior (HP:0030082)1.88311592
60Polydipsia (HP:0001959)1.88311592
61Male pseudohermaphroditism (HP:0000037)1.87823195
62Progressive inability to walk (HP:0002505)1.87728459
633-Methylglutaconic aciduria (HP:0003535)1.87155500
64Increased CSF lactate (HP:0002490)1.86444278
65Abnormality of chromosome stability (HP:0003220)1.86257577
66Intestinal atresia (HP:0011100)1.84743223
67Aplasia/Hypoplasia of the patella (HP:0006498)1.84632401
68Protruding tongue (HP:0010808)1.83973401
69Keratoconus (HP:0000563)1.83097551
70Increased corneal curvature (HP:0100692)1.83097551
71Postaxial foot polydactyly (HP:0001830)1.82890304
72Vaginal atresia (HP:0000148)1.82122361
73Aplasia/hypoplasia of the uterus (HP:0008684)1.79761066
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77620132
75Congenital hepatic fibrosis (HP:0002612)1.77414209
76Methylmalonic aciduria (HP:0012120)1.74858318
77Clubbing of toes (HP:0100760)1.73924212
78Abnormality of the ileum (HP:0001549)1.73742467
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73511311
80Optic nerve hypoplasia (HP:0000609)1.73054575
81Stomatitis (HP:0010280)1.72893435
82Acute necrotizing encephalopathy (HP:0006965)1.72521719
83Mitochondrial inheritance (HP:0001427)1.72470903
84Disproportionate short-trunk short stature (HP:0003521)1.71735147
85Progressive macrocephaly (HP:0004481)1.71285328
86Abnormality of T cell number (HP:0011839)1.70892524
87IgG deficiency (HP:0004315)1.70503658
88Decreased central vision (HP:0007663)1.70483822
89Meckel diverticulum (HP:0002245)1.69192629
90Small hand (HP:0200055)1.68102800
91Constricted visual fields (HP:0001133)1.67671838
92Sloping forehead (HP:0000340)1.64975528
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64688820
94Oligodactyly (hands) (HP:0001180)1.64434928
95Widely spaced teeth (HP:0000687)1.63782029
96Absent speech (HP:0001344)1.63376878
97Hypoplasia of the uterus (HP:0000013)1.62561824
98Dandy-Walker malformation (HP:0001305)1.62427689
99Short tibia (HP:0005736)1.61774637
100Postaxial hand polydactyly (HP:0001162)1.60842404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.40683005
2BMPR1B3.38125516
3MAP4K23.20886962
4NUAK12.55754706
5WNK32.30054873
6ADRBK22.29974056
7TRIM282.26553564
8ZAK2.25730027
9TLK12.25454609
10ACVR1B2.12833783
11GRK11.93116728
12MKNK21.91286026
13TAOK31.69747900
14MAP3K41.69608301
15OXSR11.65151606
16PINK11.60738783
17MAPK131.60054597
18TXK1.56059000
19TNIK1.55595105
20CASK1.52725503
21INSRR1.51541419
22TGFBR11.40000024
23MST41.35196255
24PLK41.30397895
25PIK3CA1.28737271
26ERBB31.22292524
27CAMKK21.18723788
28BRSK21.18396076
29TEC1.10959078
30MKNK11.09774975
31NLK1.09120707
32EIF2AK31.09002118
33PRKCG1.07053782
34WNK41.05808265
35BCR1.05049813
36STK391.04148103
37PASK1.02361294
38TAF10.97312937
39PAK30.96715352
40PLK20.92354786
41WEE10.91106132
42VRK10.89697596
43PRKCE0.87816984
44PNCK0.86103087
45STK38L0.85747448
46CDK190.84832548
47ADRBK10.84712366
48DYRK20.83262203
49BMPR20.79998794
50PLK30.79572950
51MAP4K10.77215438
52CSNK1G10.76928185
53MARK10.76622481
54MAP2K70.75567813
55IKBKB0.73290139
56KIT0.73204922
57FGFR20.70095089
58IRAK10.68099336
59DYRK30.64573582
60FLT30.64341461
61PRKCQ0.62449693
62CCNB10.61334296
63CSNK1G20.61041123
64MARK30.59063320
65PRKCI0.59028992
66CDK80.58351348
67SRPK10.57632463
68ITK0.56678725
69SGK20.55388365
70STK160.54737436
71DAPK20.53324197
72AKT30.52769541
73NTRK20.51808991
74CSNK1G30.51396344
75STK30.50963189
76TIE10.48340793
77SYK0.47564313
78BUB10.46109206
79ATR0.44869532
80CDC70.44478119
81NTRK30.44164560
82STK110.42595069
83BCKDK0.41185330
84CSNK1A1L0.40587667
85ATM0.40325937
86RPS6KA50.40236253
87EPHA30.40106767
88PLK10.38305075
89PTK2B0.38043058
90YES10.37499273
91LYN0.37171267
92GRK70.36000807
93CSNK1A10.35704033
94CAMK2A0.35333001
95MAP2K60.34866352
96LCK0.34065251
97DYRK1A0.33813035
98PRKG10.33090823
99PRKACA0.32561981
100CHUK0.30534264

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.49343537
2Protein export_Homo sapiens_hsa030602.46376222
3Homologous recombination_Homo sapiens_hsa034402.45974733
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42165181
5Fanconi anemia pathway_Homo sapiens_hsa034602.30197116
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28492057
7Basal transcription factors_Homo sapiens_hsa030222.15319002
8RNA polymerase_Homo sapiens_hsa030202.11183870
9Nicotine addiction_Homo sapiens_hsa050332.07767963
10Oxidative phosphorylation_Homo sapiens_hsa001902.02723855
11RNA degradation_Homo sapiens_hsa030182.00247542
12Caffeine metabolism_Homo sapiens_hsa002321.94299086
13Linoleic acid metabolism_Homo sapiens_hsa005911.93863491
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.92655453
15Butanoate metabolism_Homo sapiens_hsa006501.90327646
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88949908
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86945114
18Non-homologous end-joining_Homo sapiens_hsa034501.86069634
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84717865
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77644296
21Nitrogen metabolism_Homo sapiens_hsa009101.77273554
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61601792
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61552936
24Parkinsons disease_Homo sapiens_hsa050121.55190022
25Ether lipid metabolism_Homo sapiens_hsa005651.46253282
26Propanoate metabolism_Homo sapiens_hsa006401.45898430
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.44701977
28Taste transduction_Homo sapiens_hsa047421.43926400
29Selenocompound metabolism_Homo sapiens_hsa004501.41164556
30Olfactory transduction_Homo sapiens_hsa047401.39970309
31Primary immunodeficiency_Homo sapiens_hsa053401.38520910
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34383862
33Tryptophan metabolism_Homo sapiens_hsa003801.32604878
34Type I diabetes mellitus_Homo sapiens_hsa049401.24591790
35Graft-versus-host disease_Homo sapiens_hsa053321.24306583
36Regulation of autophagy_Homo sapiens_hsa041401.23275100
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16207002
38Allograft rejection_Homo sapiens_hsa053301.12025778
39Morphine addiction_Homo sapiens_hsa050321.09922172
40Asthma_Homo sapiens_hsa053101.02417101
41Peroxisome_Homo sapiens_hsa041461.02168670
42Autoimmune thyroid disease_Homo sapiens_hsa053201.01874236
43Mismatch repair_Homo sapiens_hsa034300.99031782
44Huntingtons disease_Homo sapiens_hsa050160.99016065
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98557668
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.94291059
47Purine metabolism_Homo sapiens_hsa002300.91742769
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91577037
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91031630
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.85870588
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85277512
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83930297
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83402158
54One carbon pool by folate_Homo sapiens_hsa006700.82182567
55Alzheimers disease_Homo sapiens_hsa050100.79114879
56GABAergic synapse_Homo sapiens_hsa047270.78787455
57ABC transporters_Homo sapiens_hsa020100.77946918
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76610579
59RNA transport_Homo sapiens_hsa030130.75235050
60Proteasome_Homo sapiens_hsa030500.75156434
61Chemical carcinogenesis_Homo sapiens_hsa052040.74528498
62Retinol metabolism_Homo sapiens_hsa008300.72391047
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71379559
64Pyrimidine metabolism_Homo sapiens_hsa002400.71203049
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71177833
66Serotonergic synapse_Homo sapiens_hsa047260.70662853
67Circadian entrainment_Homo sapiens_hsa047130.68791868
68Collecting duct acid secretion_Homo sapiens_hsa049660.68733479
69Nucleotide excision repair_Homo sapiens_hsa034200.67599489
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65443019
71Glutamatergic synapse_Homo sapiens_hsa047240.65236197
72Ribosome_Homo sapiens_hsa030100.63786086
73Insulin secretion_Homo sapiens_hsa049110.62899773
74Steroid biosynthesis_Homo sapiens_hsa001000.62146893
75Dorso-ventral axis formation_Homo sapiens_hsa043200.60595071
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60166848
77p53 signaling pathway_Homo sapiens_hsa041150.60000425
78Salivary secretion_Homo sapiens_hsa049700.56687614
79Circadian rhythm_Homo sapiens_hsa047100.54010460
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52886569
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50598666
82Cardiac muscle contraction_Homo sapiens_hsa042600.50006722
83Arachidonic acid metabolism_Homo sapiens_hsa005900.48114121
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47868269
85Glycerolipid metabolism_Homo sapiens_hsa005610.46297695
86Calcium signaling pathway_Homo sapiens_hsa040200.44184967
87Metabolic pathways_Homo sapiens_hsa011000.44046180
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42004090
89Dopaminergic synapse_Homo sapiens_hsa047280.41329302
90African trypanosomiasis_Homo sapiens_hsa051430.41294635
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40541684
92Base excision repair_Homo sapiens_hsa034100.40335277
93Rheumatoid arthritis_Homo sapiens_hsa053230.40330153
94Spliceosome_Homo sapiens_hsa030400.39749067
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37800516
96Ovarian steroidogenesis_Homo sapiens_hsa049130.35705435
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34771929
98Hematopoietic cell lineage_Homo sapiens_hsa046400.32664873
99Amphetamine addiction_Homo sapiens_hsa050310.32461690
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31258583

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