ZNF431

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.84075339
2negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.43725778
3negative regulation of translation, ncRNA-mediated (GO:0040033)4.43725778
4regulation of translation, ncRNA-mediated (GO:0045974)4.43725778
5neural tube formation (GO:0001841)3.93095716
6L-fucose catabolic process (GO:0042355)3.89825946
7fucose catabolic process (GO:0019317)3.89825946
8L-fucose metabolic process (GO:0042354)3.89825946
9regulation of posttranscriptional gene silencing (GO:0060147)3.81192096
10regulation of gene silencing by miRNA (GO:0060964)3.81192096
11regulation of gene silencing by RNA (GO:0060966)3.81192096
12kynurenine metabolic process (GO:0070189)3.41262255
13indolalkylamine metabolic process (GO:0006586)3.39778375
14response to pheromone (GO:0019236)3.32781224
15tryptophan catabolic process (GO:0006569)3.27825933
16indole-containing compound catabolic process (GO:0042436)3.27825933
17indolalkylamine catabolic process (GO:0046218)3.27825933
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25997947
19pyrimidine nucleobase catabolic process (GO:0006208)3.16731855
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.15303062
21rRNA catabolic process (GO:0016075)3.15294768
22regulation of hippo signaling (GO:0035330)3.13117482
23nonmotile primary cilium assembly (GO:0035058)3.09334155
24reciprocal DNA recombination (GO:0035825)3.05475566
25reciprocal meiotic recombination (GO:0007131)3.05475566
26replication fork processing (GO:0031297)3.03716642
27kidney morphogenesis (GO:0060993)3.03354585
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03245552
29regulation of nuclear cell cycle DNA replication (GO:0033262)3.03063219
30cornea development in camera-type eye (GO:0061303)3.01553694
31meiotic chromosome segregation (GO:0045132)2.97254416
32detection of light stimulus involved in visual perception (GO:0050908)2.97117583
33detection of light stimulus involved in sensory perception (GO:0050962)2.97117583
34negative regulation of transcription regulatory region DNA binding (GO:2000678)2.93335240
35negative regulation of telomere maintenance (GO:0032205)2.87290625
36somite development (GO:0061053)2.85363944
37recombinational repair (GO:0000725)2.83285747
38presynaptic membrane assembly (GO:0097105)2.82847936
39tryptophan metabolic process (GO:0006568)2.82690305
40double-strand break repair via homologous recombination (GO:0000724)2.81700357
41centriole replication (GO:0007099)2.78738098
42sulfation (GO:0051923)2.76268057
43regulation of telomere maintenance (GO:0032204)2.75966064
44interkinetic nuclear migration (GO:0022027)2.75847730
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74267814
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.74267814
47NADH dehydrogenase complex assembly (GO:0010257)2.74267814
48spinal cord motor neuron differentiation (GO:0021522)2.73530233
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73034575
50protein localization to cilium (GO:0061512)2.72766576
51positive regulation of developmental pigmentation (GO:0048087)2.67210006
52DNA deamination (GO:0045006)2.66347605
53hindbrain development (GO:0030902)2.65728491
54neuronal action potential (GO:0019228)2.65553692
55cilium organization (GO:0044782)2.65369499
56DNA demethylation (GO:0080111)2.64964275
57epithelial cilium movement (GO:0003351)2.64264156
58cilium morphogenesis (GO:0060271)2.62774655
59protein K11-linked deubiquitination (GO:0035871)2.62286261
60ncRNA catabolic process (GO:0034661)2.60554805
61retinal cone cell development (GO:0046549)2.60403921
62microtubule anchoring (GO:0034453)2.60361561
63photoreceptor cell maintenance (GO:0045494)2.59855894
64snRNA transcription (GO:0009301)2.59656527
65cilium assembly (GO:0042384)2.58627325
66photoreceptor cell development (GO:0042461)2.56226965
67behavioral response to ethanol (GO:0048149)2.56190412
68nucleobase catabolic process (GO:0046113)2.55097117
69cell proliferation in forebrain (GO:0021846)2.54530210
70presynaptic membrane organization (GO:0097090)2.54451956
71transmission of nerve impulse (GO:0019226)2.54434927
72atrial cardiac muscle cell action potential (GO:0086014)2.54202563
73indole-containing compound metabolic process (GO:0042430)2.53772629
74monoubiquitinated protein deubiquitination (GO:0035520)2.51996890
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51577563
76DNA double-strand break processing (GO:0000729)2.49739000
77histone H3-K9 methylation (GO:0051567)2.47359115
78regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46746355
79regulation of mitotic spindle checkpoint (GO:1903504)2.46746355
80regulation of mesoderm development (GO:2000380)2.45966446
81axoneme assembly (GO:0035082)2.44314421
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43911022
83somite rostral/caudal axis specification (GO:0032525)2.43475356
84cell differentiation in spinal cord (GO:0021515)2.43171042
85protein complex biogenesis (GO:0070271)2.42887152
86synapsis (GO:0007129)2.41931863
87cellular ketone body metabolic process (GO:0046950)2.40890410
88cilium or flagellum-dependent cell motility (GO:0001539)2.40334599
89head development (GO:0060322)2.39604823
90regulation of pigment cell differentiation (GO:0050932)2.39052447
91histone-serine phosphorylation (GO:0035404)2.38557089
92prenylation (GO:0097354)2.38357281
93protein prenylation (GO:0018342)2.38357281
94respiratory chain complex IV assembly (GO:0008535)2.38038586
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37295503
96eye photoreceptor cell development (GO:0042462)2.36444520
97positive regulation of oligodendrocyte differentiation (GO:0048714)2.34814542
98cardiovascular system development (GO:0072358)2.34794986
99embryonic epithelial tube formation (GO:0001838)2.32562384
100preassembly of GPI anchor in ER membrane (GO:0016254)2.29815737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.82872408
2EZH2_22144423_ChIP-Seq_EOC_Human3.45101191
3VDR_22108803_ChIP-Seq_LS180_Human3.13402626
4GBX2_23144817_ChIP-Seq_PC3_Human2.89560487
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.69482522
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56943179
7EWS_26573619_Chip-Seq_HEK293_Human2.56488574
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56090382
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55082435
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54561809
11FUS_26573619_Chip-Seq_HEK293_Human2.51505457
12IGF1R_20145208_ChIP-Seq_DFB_Human2.50172236
13TAF15_26573619_Chip-Seq_HEK293_Human2.43730489
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35572453
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30688001
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20994454
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14591358
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10580024
19P300_19829295_ChIP-Seq_ESCs_Human2.10495523
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.08759437
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88588204
22ER_23166858_ChIP-Seq_MCF-7_Human1.85424664
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81047542
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75493924
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69690164
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69690164
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66860456
28* STAT3_23295773_ChIP-Seq_U87_Human1.63083784
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.62913352
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.62355842
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61883590
32IRF1_19129219_ChIP-ChIP_H3396_Human1.61800262
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60609910
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59189041
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58607107
36SMAD4_21799915_ChIP-Seq_A2780_Human1.58403288
37* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58006906
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56786822
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.54336123
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54115536
41AR_21572438_ChIP-Seq_LNCaP_Human1.51097071
42TCF4_23295773_ChIP-Seq_U87_Human1.48871425
43CBP_20019798_ChIP-Seq_JUKART_Human1.47742223
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47742223
45BCAT_22108803_ChIP-Seq_LS180_Human1.46117899
46AR_25329375_ChIP-Seq_VCAP_Human1.45916538
47MYC_18940864_ChIP-ChIP_HL60_Human1.42485442
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41954892
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40980516
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.38992122
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38207960
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38162622
53TP53_22573176_ChIP-Seq_HFKS_Human1.35717319
54RNF2_27304074_Chip-Seq_NSC_Mouse1.34655189
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34614103
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.34588073
57REST_21632747_ChIP-Seq_MESCs_Mouse1.33305756
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26684964
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26553580
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22609475
61TCF4_22108803_ChIP-Seq_LS180_Human1.22553750
62RUNX2_22187159_ChIP-Seq_PCA_Human1.22487533
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20276165
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20127754
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19185539
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.17489263
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.17350350
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17247728
69NANOG_19829295_ChIP-Seq_ESCs_Human1.15733245
70SOX2_19829295_ChIP-Seq_ESCs_Human1.15733245
71ELK1_19687146_ChIP-ChIP_HELA_Human1.13750841
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13106728
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12725290
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.12381548
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.10658765
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.09871931
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09734225
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.09688256
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09118274
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.07719048
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.06539661
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05820778
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.05820778
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05341350
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03489902
86ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02063701
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01702896
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00709849
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.99107480
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98584860
91P53_22387025_ChIP-Seq_ESCs_Mouse0.97991038
92TP53_16413492_ChIP-PET_HCT116_Human0.97325992
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96918101
94NCOR_22424771_ChIP-Seq_293T_Human0.96372680
95HOXB7_26014856_ChIP-Seq_BT474_Human0.95452295
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.94978943
97JUN_21703547_ChIP-Seq_K562_Human0.94941136
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.94935978
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.93368551
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91527703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.28840366
2MP0003787_abnormal_imprinting2.79204302
3MP0000569_abnormal_digit_pigmentation2.78577791
4MP0006292_abnormal_olfactory_placode2.74985372
5MP0003136_yellow_coat_color2.30360258
6MP0003890_abnormal_embryonic-extraembry2.20650242
7MP0002102_abnormal_ear_morphology2.15794840
8MP0005551_abnormal_eye_electrophysiolog2.12500345
9MP0002638_abnormal_pupillary_reflex2.11132703
10MP0008057_abnormal_DNA_replication2.03414462
11MP0006276_abnormal_autonomic_nervous2.00855672
12MP0001968_abnormal_touch/_nociception2.00552987
13MP0003880_abnormal_central_pattern1.95635184
14MP0003195_calcinosis1.95556769
15MP0002837_dystrophic_cardiac_calcinosis1.93713674
16MP0002938_white_spotting1.85336883
17MP0003646_muscle_fatigue1.83341609
18MP0006072_abnormal_retinal_apoptosis1.81508674
19MP0002736_abnormal_nociception_after1.78629726
20MP0000631_abnormal_neuroendocrine_gland1.75305101
21MP0000427_abnormal_hair_cycle1.74427529
22MP0002653_abnormal_ependyma_morphology1.71869502
23MP0005253_abnormal_eye_physiology1.71800581
24MP0001986_abnormal_taste_sensitivity1.65606656
25MP0004142_abnormal_muscle_tone1.62079147
26MP0004145_abnormal_muscle_electrophysio1.61369781
27MP0004133_heterotaxia1.60602772
28MP0009046_muscle_twitch1.59831229
29MP0002160_abnormal_reproductive_system1.55061284
30MP0005645_abnormal_hypothalamus_physiol1.52599531
31MP0004043_abnormal_pH_regulation1.51217180
32MP0005174_abnormal_tail_pigmentation1.50922674
33MP0008058_abnormal_DNA_repair1.50301946
34MP0000383_abnormal_hair_follicle1.49447523
35MP0008995_early_reproductive_senescence1.47635447
36MP0003121_genomic_imprinting1.47215441
37MP0001485_abnormal_pinna_reflex1.47013334
38MP0000778_abnormal_nervous_system1.45684011
39MP0004885_abnormal_endolymph1.43869312
40MP0001188_hyperpigmentation1.41449728
41MP0009745_abnormal_behavioral_response1.40151141
42MP0008872_abnormal_physiological_respon1.38114874
43MP0003567_abnormal_fetal_cardiomyocyte1.35812748
44MP0005646_abnormal_pituitary_gland1.28396088
45MP0002272_abnormal_nervous_system1.27662491
46MP0004147_increased_porphyrin_level1.27056771
47MP0003937_abnormal_limbs/digits/tail_de1.26534615
48MP0005389_reproductive_system_phenotype1.26081160
49MP0003119_abnormal_digestive_system1.24769386
50MP0003718_maternal_effect1.22901062
51MP0008789_abnormal_olfactory_epithelium1.20796460
52MP0002557_abnormal_social/conspecific_i1.20274524
53MP0004742_abnormal_vestibular_system1.20226786
54MP0010094_abnormal_chromosome_stability1.18556278
55MP0002928_abnormal_bile_duct1.18004811
56MP0001984_abnormal_olfaction1.17847055
57MP0001529_abnormal_vocalization1.17757129
58MP0004924_abnormal_behavior1.16543983
59MP0005386_behavior/neurological_phenoty1.16543983
60MP0002095_abnormal_skin_pigmentation1.15193320
61MP0001486_abnormal_startle_reflex1.15142342
62MP0000647_abnormal_sebaceous_gland1.15097809
63MP0003011_delayed_dark_adaptation1.14714821
64MP0002735_abnormal_chemical_nociception1.13531363
65MP0001293_anophthalmia1.10850441
66MP0001919_abnormal_reproductive_system1.09398506
67MP0002067_abnormal_sensory_capabilities1.08053610
68MP0005499_abnormal_olfactory_system1.07681600
69MP0005394_taste/olfaction_phenotype1.07681600
70MP0002572_abnormal_emotion/affect_behav1.06491397
71MP0005195_abnormal_posterior_eye1.06184000
72MP0002751_abnormal_autonomic_nervous1.03279887
73MP0000372_irregular_coat_pigmentation0.99557680
74MP0005423_abnormal_somatic_nervous0.99048984
75MP0002234_abnormal_pharynx_morphology0.98924356
76MP0008961_abnormal_basal_metabolism0.98820158
77MP0002752_abnormal_somatic_nervous0.98210284
78MP0004215_abnormal_myocardial_fiber0.97483026
79MP0003698_abnormal_male_reproductive0.96343536
80MP0002063_abnormal_learning/memory/cond0.96311152
81MP0002184_abnormal_innervation0.96202875
82MP0002210_abnormal_sex_determination0.95310627
83MP0005187_abnormal_penis_morphology0.93649655
84MP0004130_abnormal_muscle_cell0.93490523
85MP0001501_abnormal_sleep_pattern0.93083554
86MP0003635_abnormal_synaptic_transmissio0.93022476
87MP0001970_abnormal_pain_threshold0.91880284
88MP0000955_abnormal_spinal_cord0.90850714
89MP0002064_seizures0.90599225
90MP0001929_abnormal_gametogenesis0.89171025
91MP0002733_abnormal_thermal_nociception0.89026001
92MP0005391_vision/eye_phenotype0.87819865
93MP0001286_abnormal_eye_development0.87387345
94MP0002163_abnormal_gland_morphology0.86380961
95MP0005084_abnormal_gallbladder_morpholo0.86094970
96MP0001324_abnormal_eye_pigmentation0.84771989
97MP0000653_abnormal_sex_gland0.77924677
98MP0001145_abnormal_male_reproductive0.76994973
99MP0003693_abnormal_embryo_hatching0.76928898
100MP0002882_abnormal_neuron_morphology0.75360360

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.13367445
2Pancreatic fibrosis (HP:0100732)3.84740030
3Abnormality of midbrain morphology (HP:0002418)3.77336987
4Molar tooth sign on MRI (HP:0002419)3.77336987
5True hermaphroditism (HP:0010459)3.48113249
6Congenital stationary night blindness (HP:0007642)3.45066936
7Nephronophthisis (HP:0000090)3.29956388
8Hyperventilation (HP:0002883)3.17329713
9Protruding tongue (HP:0010808)3.07485537
10Chronic hepatic failure (HP:0100626)3.04415751
11Abnormality of the renal cortex (HP:0011035)3.02999068
12Abnormality of the renal medulla (HP:0100957)3.02940031
13Genetic anticipation (HP:0003743)3.01704833
14Attenuation of retinal blood vessels (HP:0007843)2.70191639
15Tubular atrophy (HP:0000092)2.68095789
16Birth length less than 3rd percentile (HP:0003561)2.67017639
17Progressive cerebellar ataxia (HP:0002073)2.66719005
18Medial flaring of the eyebrow (HP:0010747)2.60883347
19Patellar aplasia (HP:0006443)2.57056797
20Cystic liver disease (HP:0006706)2.49673509
21Abnormality of alanine metabolism (HP:0010916)2.49110104
22Hyperalaninemia (HP:0003348)2.49110104
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49110104
24Pendular nystagmus (HP:0012043)2.47338580
25Abolished electroretinogram (ERG) (HP:0000550)2.45686715
26Type II lissencephaly (HP:0007260)2.45324640
27Lissencephaly (HP:0001339)2.43568363
28Aplasia/Hypoplasia of the patella (HP:0006498)2.41371633
29Colon cancer (HP:0003003)2.41288646
30Gaze-evoked nystagmus (HP:0000640)2.38448631
31Broad-based gait (HP:0002136)2.37030652
32Inability to walk (HP:0002540)2.36849859
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.36047743
34Cerebellar dysplasia (HP:0007033)2.29242603
35Progressive inability to walk (HP:0002505)2.26643551
36Chorioretinal atrophy (HP:0000533)2.19725341
37Abnormality of the pons (HP:0007361)2.12221329
38Anencephaly (HP:0002323)2.10867059
39Gait imbalance (HP:0002141)2.10709350
40Hypoplasia of the pons (HP:0012110)2.09046972
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.08603347
42Renal cortical cysts (HP:0000803)2.07778497
43Bony spicule pigmentary retinopathy (HP:0007737)2.07174490
44Abnormal biliary tract physiology (HP:0012439)2.06789500
45Bile duct proliferation (HP:0001408)2.06789500
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06019292
47Polydipsia (HP:0001959)2.05692589
48Abnormal drinking behavior (HP:0030082)2.05692589
49Congenital primary aphakia (HP:0007707)2.04796194
50Abnormality of the labia minora (HP:0012880)2.03974205
51Abnormality of the renal collecting system (HP:0004742)2.02130383
52Optic nerve hypoplasia (HP:0000609)2.00787478
53Furrowed tongue (HP:0000221)2.00491443
54Sclerocornea (HP:0000647)1.98958684
55Congenital hepatic fibrosis (HP:0002612)1.98875619
56Aplasia/Hypoplasia of the tongue (HP:0010295)1.97946794
57Nephrogenic diabetes insipidus (HP:0009806)1.97869428
58Duplicated collecting system (HP:0000081)1.96430887
59Dynein arm defect of respiratory motile cilia (HP:0012255)1.95584300
60Absent/shortened dynein arms (HP:0200106)1.95584300
61Genital tract atresia (HP:0001827)1.95546806
62Rib fusion (HP:0000902)1.95260760
63Clumsiness (HP:0002312)1.95188457
64Bilateral microphthalmos (HP:0007633)1.94025527
65Drooling (HP:0002307)1.92797277
66Small hand (HP:0200055)1.91055622
67Decreased circulating renin level (HP:0003351)1.89878123
68Ectopic kidney (HP:0000086)1.89374985
69Vaginal atresia (HP:0000148)1.88889570
70Partial agenesis of the corpus callosum (HP:0001338)1.88071594
71Male pseudohermaphroditism (HP:0000037)1.87904753
72Stomach cancer (HP:0012126)1.87520524
73Decreased central vision (HP:0007663)1.86848855
74Neoplasm of the adrenal cortex (HP:0100641)1.85334735
75Dandy-Walker malformation (HP:0001305)1.84731226
76Fair hair (HP:0002286)1.82566138
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80226838
78Sloping forehead (HP:0000340)1.79881214
79Pachygyria (HP:0001302)1.79208124
80Congenital, generalized hypertrichosis (HP:0004540)1.78440111
81Keratoconus (HP:0000563)1.78196637
82Increased corneal curvature (HP:0100692)1.78196637
83Poor coordination (HP:0002370)1.77533795
84Postaxial foot polydactyly (HP:0001830)1.77171977
85Abnormality of the ileum (HP:0001549)1.77054639
86Hypoplastic iliac wings (HP:0002866)1.76540747
87Preaxial hand polydactyly (HP:0001177)1.75868884
88Febrile seizures (HP:0002373)1.75091528
89Oligodactyly (hands) (HP:0001180)1.75056276
90Meckel diverticulum (HP:0002245)1.74955522
91Concave nail (HP:0001598)1.74950788
92Abnormality of chromosome stability (HP:0003220)1.72892777
93Intestinal atresia (HP:0011100)1.72430190
94Volvulus (HP:0002580)1.72402960
95Large for gestational age (HP:0001520)1.72184611
96Chromsome breakage (HP:0040012)1.72118444
97Excessive salivation (HP:0003781)1.71264583
98Widely spaced teeth (HP:0000687)1.70954245
99Abnormal number of erythroid precursors (HP:0012131)1.69977202
100Polyuria (HP:0000103)1.68748895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.99955029
2BMPR1B3.33497073
3ACVR1B3.02042763
4ADRBK22.54974571
5ZAK2.44133497
6NUAK12.40661628
7WNK32.37163191
8CASK2.33273872
9MKNK22.18510930
10MAPK131.93844759
11GRK11.91395594
12INSRR1.88718388
13WNK41.81636754
14TLK11.74134484
15MAP4K21.72419590
16MAP3K41.62194780
17MKNK11.44089287
18PINK11.43125032
19TAOK31.41154223
20AKT31.40367284
21BRSK21.37673351
22TNIK1.34605090
23OXSR11.33836053
24CAMKK21.32550268
25TGFBR11.32370023
26MARK11.28329749
27PNCK1.27435752
28PLK41.21920238
29DYRK21.10969906
30TRIM281.08828751
31STK391.08035103
32CDC71.06016443
33WEE11.05157238
34NLK1.00473652
35NEK20.99904863
36ADRBK10.99039650
37VRK10.96609966
38FGFR20.95556911
39STK38L0.95350385
40PAK30.93587316
41SGK20.91256954
42TAF10.90171803
43STK30.86909985
44DAPK20.85971601
45DYRK30.84247551
46MUSK0.83872307
47PIK3CA0.80771266
48TXK0.80766387
49MAPK150.77600737
50MAP2K70.76230414
51TEC0.73350361
52PRKCG0.73323204
53SIK20.73265671
54STK110.72186233
55CAMK1D0.70902887
56CAMK1G0.70104224
57ATR0.70059285
58SGK4940.68411291
59SGK2230.68411291
60LATS10.66044208
61BCR0.65397302
62PRKCE0.64667592
63CHEK20.64544162
64OBSCN0.64151171
65BRD40.61032209
66RPS6KA50.59871250
67PLK30.59183928
68CSNK1G10.59147920
69CSNK1G20.58601135
70CSNK1A1L0.58123630
71FLT30.56678379
72NTRK30.56473393
73MAPKAPK50.54893972
74ERBB30.52389516
75ATM0.51108988
76PLK10.50838074
77CAMK10.47739833
78NTRK20.47217365
79PASK0.46164111
80PLK20.45734638
81MELK0.45042315
82TIE10.43994460
83CAMKK10.43316946
84ERBB20.42994852
85DYRK1A0.42871807
86MAP3K70.42691359
87IRAK10.41046325
88EPHA40.40384343
89CSNK1D0.40084011
90CDK30.39858594
91CAMK40.39614608
92CSNK1G30.38317219
93CAMK2A0.37844327
94CHUK0.35853106
95PRKACA0.34769693
96EPHA30.34332404
97PRKCQ0.33545863
98RPS6KA60.33467279
99PKN10.32799502
100SRPK10.32386725

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.89965097
2Homologous recombination_Homo sapiens_hsa034402.63671264
3Fanconi anemia pathway_Homo sapiens_hsa034602.55090648
4Nitrogen metabolism_Homo sapiens_hsa009102.43578803
5Nicotine addiction_Homo sapiens_hsa050332.41085730
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31593304
7Linoleic acid metabolism_Homo sapiens_hsa005912.30681891
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17098391
9Butanoate metabolism_Homo sapiens_hsa006502.14167449
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12182066
11Basal transcription factors_Homo sapiens_hsa030222.08484644
12Selenocompound metabolism_Homo sapiens_hsa004502.04253151
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94432083
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93860827
15Ether lipid metabolism_Homo sapiens_hsa005651.92757965
16Taste transduction_Homo sapiens_hsa047421.86315454
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83461839
18RNA polymerase_Homo sapiens_hsa030201.78734199
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75246802
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69735444
21RNA degradation_Homo sapiens_hsa030181.65316571
22Olfactory transduction_Homo sapiens_hsa047401.55881133
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.55857255
24Tryptophan metabolism_Homo sapiens_hsa003801.48439396
25Oxidative phosphorylation_Homo sapiens_hsa001901.47162551
26Protein export_Homo sapiens_hsa030601.45738327
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35918665
28Morphine addiction_Homo sapiens_hsa050321.30856475
29Non-homologous end-joining_Homo sapiens_hsa034501.29401799
30Glutamatergic synapse_Homo sapiens_hsa047241.23078298
31One carbon pool by folate_Homo sapiens_hsa006701.21363953
32Parkinsons disease_Homo sapiens_hsa050121.18835163
33ABC transporters_Homo sapiens_hsa020101.13113737
34Circadian entrainment_Homo sapiens_hsa047131.10225887
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09760864
36Serotonergic synapse_Homo sapiens_hsa047261.08244205
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08061046
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07722452
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.06697380
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04471235
41Caffeine metabolism_Homo sapiens_hsa002321.02811927
42Propanoate metabolism_Homo sapiens_hsa006401.00244554
43Regulation of autophagy_Homo sapiens_hsa041401.00229251
44GABAergic synapse_Homo sapiens_hsa047270.99323051
45Huntingtons disease_Homo sapiens_hsa050160.97011206
46Dorso-ventral axis formation_Homo sapiens_hsa043200.96270142
47Cardiac muscle contraction_Homo sapiens_hsa042600.94246141
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91265096
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90260574
50Ovarian steroidogenesis_Homo sapiens_hsa049130.89449404
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88855191
52Basal cell carcinoma_Homo sapiens_hsa052170.82974598
53Lysine degradation_Homo sapiens_hsa003100.82348612
54Calcium signaling pathway_Homo sapiens_hsa040200.82181398
55Long-term depression_Homo sapiens_hsa047300.78314349
56Insulin secretion_Homo sapiens_hsa049110.77725319
57Peroxisome_Homo sapiens_hsa041460.77587298
58Glycerolipid metabolism_Homo sapiens_hsa005610.74172999
59Mismatch repair_Homo sapiens_hsa034300.72646200
60Nucleotide excision repair_Homo sapiens_hsa034200.71848539
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71165641
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.70516121
63Retinol metabolism_Homo sapiens_hsa008300.69508716
64Alzheimers disease_Homo sapiens_hsa050100.69142616
65Hedgehog signaling pathway_Homo sapiens_hsa043400.69038722
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68743037
67Arachidonic acid metabolism_Homo sapiens_hsa005900.68671167
68Cholinergic synapse_Homo sapiens_hsa047250.67378663
69RNA transport_Homo sapiens_hsa030130.67277561
70Dopaminergic synapse_Homo sapiens_hsa047280.66625420
71Purine metabolism_Homo sapiens_hsa002300.64248266
72Circadian rhythm_Homo sapiens_hsa047100.63653912
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63516863
74Chemical carcinogenesis_Homo sapiens_hsa052040.63422672
75Cocaine addiction_Homo sapiens_hsa050300.61412668
76p53 signaling pathway_Homo sapiens_hsa041150.60418971
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60178737
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.59511394
79Vitamin digestion and absorption_Homo sapiens_hsa049770.58116437
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57029772
81Cell cycle_Homo sapiens_hsa041100.55915487
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55387757
83Steroid biosynthesis_Homo sapiens_hsa001000.53414075
84cAMP signaling pathway_Homo sapiens_hsa040240.52413639
85Ribosome_Homo sapiens_hsa030100.52397719
86TGF-beta signaling pathway_Homo sapiens_hsa043500.52147567
87Salivary secretion_Homo sapiens_hsa049700.51135200
88Axon guidance_Homo sapiens_hsa043600.50951534
89Amphetamine addiction_Homo sapiens_hsa050310.50640291
90Oxytocin signaling pathway_Homo sapiens_hsa049210.48269641
91Histidine metabolism_Homo sapiens_hsa003400.46282425
92Hippo signaling pathway_Homo sapiens_hsa043900.44635546
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.44224816
94Primary immunodeficiency_Homo sapiens_hsa053400.44000177
95Alcoholism_Homo sapiens_hsa050340.42465337
96Sulfur relay system_Homo sapiens_hsa041220.41093403
97beta-Alanine metabolism_Homo sapiens_hsa004100.39746805
98Pyrimidine metabolism_Homo sapiens_hsa002400.37508489
99mRNA surveillance pathway_Homo sapiens_hsa030150.37144920
100Metabolic pathways_Homo sapiens_hsa011000.35764378

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