ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.41996279
2	behavioral response to nicotine (GO:0035095)	4.52820712
3	epithelial cilium movement (GO:0003351)	4.51525127
4	piRNA metabolic process (GO:0034587)	4.21505747
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.13560436
6	response to pheromone (GO:0019236)	3.91328800
7	neural tube formation (GO:0001841)	3.84550763
8	nonmotile primary cilium assembly (GO:0035058)	3.81786768
9	regulation of cilium movement (GO:0003352)	3.72412494
10	pyrimidine nucleobase catabolic process (GO:0006208)	3.71371037
11	cilium movement (GO:0003341)	3.65306381
12	centriole replication (GO:0007099)	3.58466210
13	reflex (GO:0060004)	3.54352360
14	cornea development in camera-type eye (GO:0061303)	3.54078857
15	somite development (GO:0061053)	3.49914978
16	presynaptic membrane assembly (GO:0097105)	3.43709266
17	L-fucose catabolic process (GO:0042355)	3.40781328
18	fucose catabolic process (GO:0019317)	3.40781328
19	L-fucose metabolic process (GO:0042354)	3.40781328
20	cilium morphogenesis (GO:0060271)	3.40200844
21	postsynaptic membrane organization (GO:0001941)	3.37552928
22	axoneme assembly (GO:0035082)	3.32850275
23	regulation of telomere maintenance (GO:0032204)	3.30328346
24	righting reflex (GO:0060013)	3.28772844
25	cilium organization (GO:0044782)	3.25048332
26	establishment of protein localization to Golgi (GO:0072600)	3.17069213
27	cilium assembly (GO:0042384)	3.15180062
28	DNA methylation involved in gamete generation (GO:0043046)	3.12123425
29	regulation of collateral sprouting (GO:0048670)	3.11977650
30	behavioral response to ethanol (GO:0048149)	3.10911163
31	protein localization to Golgi apparatus (GO:0034067)	3.09533509
32	limb bud formation (GO:0060174)	3.08972529
33	protein polyglutamylation (GO:0018095)	3.08661389
34	single strand break repair (GO:0000012)	3.07750544
35	inner ear receptor stereocilium organization (GO:0060122)	3.07360848
36	startle response (GO:0001964)	3.07066497
37	olfactory bulb development (GO:0021772)	3.05153858
38	protein-cofactor linkage (GO:0018065)	3.04198882
39	auditory receptor cell stereocilium organization (GO:0060088)	3.01161665
40	cilium or flagellum-dependent cell motility (GO:0001539)	3.00947448
41	detection of light stimulus involved in visual perception (GO:0050908)	3.00664073
42	detection of light stimulus involved in sensory perception (GO:0050962)	3.00664073
43	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.97839253
44	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.97839253
45	regulation of translation, ncRNA-mediated (GO:0045974)	2.97839253
46	protein K11-linked deubiquitination (GO:0035871)	2.97238988
47	presynaptic membrane organization (GO:0097090)	2.96343889
48	photoreceptor cell maintenance (GO:0045494)	2.94105064
49	regulation of hippo signaling (GO:0035330)	2.93627853
50	nucleobase catabolic process (GO:0046113)	2.89761122
51	neuronal action potential (GO:0019228)	2.88613794
52	protein targeting to Golgi (GO:0000042)	2.81398455
53	axonemal dynein complex assembly (GO:0070286)	2.80313544
54	indolalkylamine metabolic process (GO:0006586)	2.77356128
55	intraciliary transport (GO:0042073)	2.76509581
56	kidney morphogenesis (GO:0060993)	2.76337434
57	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.76012823
58	glycosphingolipid biosynthetic process (GO:0006688)	2.72626801
59	platelet dense granule organization (GO:0060155)	2.70581149
60	cellular ketone body metabolic process (GO:0046950)	2.68601350
61	protein import into peroxisome matrix (GO:0016558)	2.67155628
62	regulation of microtubule-based movement (GO:0060632)	2.66911788
63	regulation of meiosis I (GO:0060631)	2.64888098
64	peristalsis (GO:0030432)	2.64548395
65	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.63185637
66	regulation of action potential (GO:0098900)	2.59960924
67	positive regulation of mitochondrial fission (GO:0090141)	2.59853516
68	photoreceptor cell development (GO:0042461)	2.58265826
69	nephron epithelium morphogenesis (GO:0072088)	2.57561416
70	nephron tubule morphogenesis (GO:0072078)	2.57561416
71	negative regulation of telomere maintenance (GO:0032205)	2.56573015
72	preassembly of GPI anchor in ER membrane (GO:0016254)	2.56275741
73	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.55557261
74	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.55299683
75	embryonic epithelial tube formation (GO:0001838)	2.53655916
76	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.53536196
77	male meiosis (GO:0007140)	2.52281517
78	sperm motility (GO:0030317)	2.50876682
79	acrosome reaction (GO:0007340)	2.50657964
80	C4-dicarboxylate transport (GO:0015740)	2.49767747
81	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.48572170
82	replication fork processing (GO:0031297)	2.47589642
83	multicellular organism reproduction (GO:0032504)	2.47044268
84	rRNA catabolic process (GO:0016075)	2.47032155
85	anterograde axon cargo transport (GO:0008089)	2.46814611
86	brain morphogenesis (GO:0048854)	2.45325925
87	spinal cord motor neuron differentiation (GO:0021522)	2.44772583
88	retinal cone cell development (GO:0046549)	2.44218340
89	synapsis (GO:0007129)	2.44000769
90	positive regulation of action potential (GO:0045760)	2.43828544
91	peptidyl-lysine trimethylation (GO:0018023)	2.43272451
92	cellular component assembly involved in morphogenesis (GO:0010927)	2.42726956
93	renal tubule morphogenesis (GO:0061333)	2.41372243
94	cAMP catabolic process (GO:0006198)	2.41259125
95	histone H3-K9 methylation (GO:0051567)	2.40807170
96	positive regulation of meiosis (GO:0045836)	2.40436113
97	protein localization to cilium (GO:0061512)	2.40323009
98	tryptophan catabolic process (GO:0006569)	2.40229200
99	indole-containing compound catabolic process (GO:0042436)	2.40229200
100	indolalkylamine catabolic process (GO:0046218)	2.40229200

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78210248
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.04340786
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.84124172
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.82123755
5	VDR_22108803_ChIP-Seq_LS180_Human	2.74236705
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.73242536
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.65732806
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.57256717
9	FUS_26573619_Chip-Seq_HEK293_Human	2.53739140
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37115321
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.36713908
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32486156
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.31943278
14	EWS_26573619_Chip-Seq_HEK293_Human	2.25104151
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.24371270
16	P300_19829295_ChIP-Seq_ESCs_Human	2.20048018
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17583734
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.03021326
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.02928040
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.02345886
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.97981252
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.93216171
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81668937
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.81643915
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.76966522
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.69439013
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67526096
28	STAT3_23295773_ChIP-Seq_U87_Human	1.66655746
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66342651
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63903093
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63101667
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63101667
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.62101481
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62097321
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58074781
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.56658839
37	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.56423448
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56283406
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55480860
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55315979
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.54329553
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53670507
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.53670507
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.53614836
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.52864747
46	AR_25329375_ChIP-Seq_VCAP_Human	1.52149237
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48621634
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47564660
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46893608
50	TCF4_23295773_ChIP-Seq_U87_Human	1.46297577
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.46242689
52	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45422156
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44775822
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.43579400
55	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.42570256
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40611492
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39106097
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38351038
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38250029
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35427395
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.29640292
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29048137
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.28785534
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28022221
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26871818
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26258410
67	AR_21572438_ChIP-Seq_LNCaP_Human	1.21466899
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20046106
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19397560
70	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.18987466
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17787430
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17765434
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17672738
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12566836
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11625605
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11039806
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10994629
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10731524
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10731524
80	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.10132602
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09714987
82	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09644175
83	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08627456
84	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07825601
85	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07398312
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05637801
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05126362
88	CDX2_22108803_ChIP-Seq_LS180_Human	1.04763922
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04675534
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04382249
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.02177282
92	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.02005800
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00958846
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00958846
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00138897
96	MYC_18940864_ChIP-ChIP_HL60_Human	1.00096011
97	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99164302
98	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98963301
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.98217957
100	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97071626

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.05151601
2	MP0008877_abnormal_DNA_methylation	3.12920687
3	MP0003787_abnormal_imprinting	2.63803810
4	MP0001984_abnormal_olfaction	2.50905303
5	MP0006292_abnormal_olfactory_placode	2.43435668
6	MP0003195_calcinosis	2.41911632
7	MP0002102_abnormal_ear_morphology	2.34731658
8	MP0002638_abnormal_pupillary_reflex	2.13696190
9	MP0000427_abnormal_hair_cycle	2.06252296
10	MP0003011_delayed_dark_adaptation	2.05579948
11	MP0002736_abnormal_nociception_after	2.04615074
12	MP0003122_maternal_imprinting	2.04592968
13	MP0001968_abnormal_touch/_nociception	2.04001356
14	MP0004885_abnormal_endolymph	1.96997604
15	MP0005551_abnormal_eye_electrophysiolog	1.95686176
16	MP0003121_genomic_imprinting	1.88375642
17	MP0001501_abnormal_sleep_pattern	1.83776918
18	MP0008057_abnormal_DNA_replication	1.75351518
19	MP0001986_abnormal_taste_sensitivity	1.75313855
20	MP0001485_abnormal_pinna_reflex	1.75166889
21	MP0000778_abnormal_nervous_system	1.73590425
22	MP0003880_abnormal_central_pattern	1.72850434
23	MP0001486_abnormal_startle_reflex	1.72195432
24	MP0000383_abnormal_hair_follicle	1.70656980
25	MP0006072_abnormal_retinal_apoptosis	1.67587389
26	MP0003136_yellow_coat_color	1.66321571
27	MP0002938_white_spotting	1.66004408
28	MP0006276_abnormal_autonomic_nervous	1.63718142
29	MP0009046_muscle_twitch	1.62832724
30	MP0004742_abnormal_vestibular_system	1.59008829
31	MP0003890_abnormal_embryonic-extraembry	1.56164470
32	MP0005253_abnormal_eye_physiology	1.55212367
33	MP0003646_muscle_fatigue	1.54598143
34	MP0002735_abnormal_chemical_nociception	1.51811518
35	MP0004142_abnormal_muscle_tone	1.50607219
36	MP0002928_abnormal_bile_duct	1.49000037
37	MP0001529_abnormal_vocalization	1.48694699
38	MP0008789_abnormal_olfactory_epithelium	1.44305520
39	MP0002272_abnormal_nervous_system	1.41764859
40	MP0002837_dystrophic_cardiac_calcinosis	1.41075167
41	MP0009745_abnormal_behavioral_response	1.39739456
42	MP0000372_irregular_coat_pigmentation	1.34448931
43	MP0004133_heterotaxia	1.34058566
44	MP0002876_abnormal_thyroid_physiology	1.32841925
45	MP0002557_abnormal_social/conspecific_i	1.32215883
46	MP0000631_abnormal_neuroendocrine_gland	1.30536299
47	MP0005645_abnormal_hypothalamus_physiol	1.28550912
48	MP0003252_abnormal_bile_duct	1.27601555
49	MP0005174_abnormal_tail_pigmentation	1.25235992
50	MP0005423_abnormal_somatic_nervous	1.25119262
51	MP0000647_abnormal_sebaceous_gland	1.24858824
52	MP0002653_abnormal_ependyma_morphology	1.23954833
53	MP0004043_abnormal_pH_regulation	1.22701026
54	MP0008995_early_reproductive_senescence	1.21377029
55	MP0003878_abnormal_ear_physiology	1.17985518
56	MP0005377_hearing/vestibular/ear_phenot	1.17985518
57	MP0005084_abnormal_gallbladder_morpholo	1.17838511
58	MP0002234_abnormal_pharynx_morphology	1.16360731
59	MP0003937_abnormal_limbs/digits/tail_de	1.15709239
60	MP0004924_abnormal_behavior	1.13688635
61	MP0005386_behavior/neurological_phenoty	1.13688635
62	MP0005646_abnormal_pituitary_gland	1.12893833
63	MP0004145_abnormal_muscle_electrophysio	1.12688977
64	MP0001502_abnormal_circadian_rhythm	1.12325882
65	MP0002572_abnormal_emotion/affect_behav	1.11342943
66	MP0002751_abnormal_autonomic_nervous	1.06950269
67	MP0002067_abnormal_sensory_capabilities	1.06494972
68	MP0002734_abnormal_mechanical_nocicepti	1.06016683
69	MP0005195_abnormal_posterior_eye	1.03508614
70	MP0010678_abnormal_skin_adnexa	1.02674077
71	MP0008058_abnormal_DNA_repair	1.01052703
72	MP0005499_abnormal_olfactory_system	0.99891212
73	MP0005394_taste/olfaction_phenotype	0.99891212
74	MP0008875_abnormal_xenobiotic_pharmacok	0.98901792
75	MP0000026_abnormal_inner_ear	0.98798917
76	MP0002752_abnormal_somatic_nervous	0.97552738
77	MP0010386_abnormal_urinary_bladder	0.95259533
78	MP0003635_abnormal_synaptic_transmissio	0.94996177
79	MP0005389_reproductive_system_phenotype	0.93732832
80	MP0002210_abnormal_sex_determination	0.92019054
81	MP0002138_abnormal_hepatobiliary_system	0.91993056
82	MP0003698_abnormal_male_reproductive	0.90416704
83	MP0001929_abnormal_gametogenesis	0.89109345
84	MP0001970_abnormal_pain_threshold	0.88757342
85	MP0002063_abnormal_learning/memory/cond	0.88053268
86	MP0002160_abnormal_reproductive_system	0.87920226
87	MP0004134_abnormal_chest_morphology	0.87266311
88	MP0002064_seizures	0.86973350
89	MP0002184_abnormal_innervation	0.85486713
90	MP0002095_abnormal_skin_pigmentation	0.85264421
91	MP0002733_abnormal_thermal_nociception	0.83328952
92	MP0004215_abnormal_myocardial_fiber	0.82885487
93	MP0002163_abnormal_gland_morphology	0.82859832
94	MP0000613_abnormal_salivary_gland	0.82684238
95	MP0001919_abnormal_reproductive_system	0.81111481
96	MP0003718_maternal_effect	0.81071354
97	MP0003938_abnormal_ear_development	0.80715627
98	MP0005391_vision/eye_phenotype	0.80537995
99	MP0000049_abnormal_middle_ear	0.80195265
100	MP0001440_abnormal_grooming_behavior	0.80023156

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.66783545
2	Abnormality of midbrain morphology (HP:0002418)	4.43840836
3	Molar tooth sign on MRI (HP:0002419)	4.43840836
4	True hermaphroditism (HP:0010459)	4.33547063
5	Pancreatic fibrosis (HP:0100732)	4.14015245
6	Nephronophthisis (HP:0000090)	4.04182026
7	Medial flaring of the eyebrow (HP:0010747)	3.82052858
8	Abnormality of the renal medulla (HP:0100957)	3.49257980
9	Hyperventilation (HP:0002883)	3.24863065
10	Chronic hepatic failure (HP:0100626)	3.10482878
11	Abnormality of the renal cortex (HP:0011035)	3.05924142
12	Abnormality of the labia minora (HP:0012880)	3.05077983
13	Tubular atrophy (HP:0000092)	3.05045710
14	Cystic liver disease (HP:0006706)	2.91570992
15	Gait imbalance (HP:0002141)	2.90917496
16	Congenital primary aphakia (HP:0007707)	2.84405739
17	Attenuation of retinal blood vessels (HP:0007843)	2.80992088
18	Gaze-evoked nystagmus (HP:0000640)	2.80873552
19	Type II lissencephaly (HP:0007260)	2.60107707
20	Abnormal drinking behavior (HP:0030082)	2.58136546
21	Polydipsia (HP:0001959)	2.58136546
22	Genital tract atresia (HP:0001827)	2.49454740
23	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.48422109
24	Nephrogenic diabetes insipidus (HP:0009806)	2.47194513
25	Vaginal atresia (HP:0000148)	2.46925435
26	Sclerocornea (HP:0000647)	2.37905978
27	Progressive inability to walk (HP:0002505)	2.37680887
28	Febrile seizures (HP:0002373)	2.36378536
29	Bile duct proliferation (HP:0001408)	2.35980421
30	Abnormal biliary tract physiology (HP:0012439)	2.35980421
31	Congenital stationary night blindness (HP:0007642)	2.34986278
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31883017
33	Inability to walk (HP:0002540)	2.31212950
34	Postaxial hand polydactyly (HP:0001162)	2.30757883
35	Absent/shortened dynein arms (HP:0200106)	2.30755825
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30755825
37	Drooling (HP:0002307)	2.30167708
38	Anencephaly (HP:0002323)	2.28856338
39	Stomach cancer (HP:0012126)	2.26027738
40	Progressive cerebellar ataxia (HP:0002073)	2.22250357
41	Pendular nystagmus (HP:0012043)	2.22191653
42	Genetic anticipation (HP:0003743)	2.21946467
43	Volvulus (HP:0002580)	2.19697833
44	Poor coordination (HP:0002370)	2.19409180
45	Congenital hepatic fibrosis (HP:0002612)	2.18398233
46	Concave nail (HP:0001598)	2.17805935
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.17417597
48	Abnormal respiratory motile cilium morphology (HP:0005938)	2.17417597
49	Furrowed tongue (HP:0000221)	2.16747604
50	Male pseudohermaphroditism (HP:0000037)	2.15087734
51	Postaxial foot polydactyly (HP:0001830)	2.14129645
52	Abnormality of alanine metabolism (HP:0010916)	2.13335194
53	Hyperalaninemia (HP:0003348)	2.13335194
54	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13335194
55	Narrow forehead (HP:0000341)	2.10564282
56	Optic nerve hypoplasia (HP:0000609)	2.08335492
57	Abnormal ciliary motility (HP:0012262)	2.06622414
58	Excessive salivation (HP:0003781)	2.05677588
59	Abolished electroretinogram (ERG) (HP:0000550)	2.00345626
60	Chorioretinal atrophy (HP:0000533)	1.98756415
61	Broad-based gait (HP:0002136)	1.98419110
62	Short foot (HP:0001773)	1.95411702
63	Oculomotor apraxia (HP:0000657)	1.93649802
64	Short tibia (HP:0005736)	1.93622837
65	Occipital encephalocele (HP:0002085)	1.93574485
66	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93055324
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92766848
68	Intestinal atresia (HP:0011100)	1.90994454
69	Hypoplastic labia majora (HP:0000059)	1.89753384
70	Polyuria (HP:0000103)	1.89371680
71	Widely spaced teeth (HP:0000687)	1.89127307
72	Protruding tongue (HP:0010808)	1.88734324
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.88442251
74	Renal cortical cysts (HP:0000803)	1.87824692
75	Increased corneal curvature (HP:0100692)	1.87326225
76	Keratoconus (HP:0000563)	1.87326225
77	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87259608
78	Prominent nasal bridge (HP:0000426)	1.86248323
79	Disproportionate short-trunk short stature (HP:0003521)	1.85073974
80	Supernumerary spleens (HP:0009799)	1.81667985
81	Absent speech (HP:0001344)	1.81617383
82	Bony spicule pigmentary retinopathy (HP:0007737)	1.81228209
83	Cerebellar dysplasia (HP:0007033)	1.80430970
84	Abnormality of the labia majora (HP:0012881)	1.80273419
85	Congenital sensorineural hearing impairment (HP:0008527)	1.78757242
86	Rhinitis (HP:0012384)	1.76556418
87	Astigmatism (HP:0000483)	1.75643119
88	Lissencephaly (HP:0001339)	1.75141543
89	Dandy-Walker malformation (HP:0001305)	1.75000542
90	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.74783238
91	Large for gestational age (HP:0001520)	1.74541390
92	Pachygyria (HP:0001302)	1.72943695
93	Preaxial hand polydactyly (HP:0001177)	1.72123480
94	Tubulointerstitial nephritis (HP:0001970)	1.71302001
95	Labial hypoplasia (HP:0000066)	1.71202173
96	Aplasia/Hypoplasia of the lens (HP:0008063)	1.70680489
97	Polyphagia (HP:0002591)	1.69825449
98	Multicystic kidney dysplasia (HP:0000003)	1.68115722
99	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.68017041
100	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.68017041

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.88795591
2	CASK	3.31918686
3	MAP4K2	2.74766529
4	ACVR1B	2.59536344
5	WNK3	2.56467605
6	BMPR1B	2.42661263
7	BCR	2.23258425
8	ADRBK2	2.20796892
9	MAPK13	2.05532600
10	MAP3K4	2.00443136
11	PINK1	1.87468607
12	ZAK	1.86245966
13	TAOK3	1.75651343
14	MKNK2	1.73651028
15	TNIK	1.72575141
16	TAF1	1.70784801
17	NUAK1	1.53392091
18	TRIM28	1.52683641
19	AKT3	1.51754458
20	ERBB3	1.47900314
21	STK38L	1.47611901
22	MARK1	1.45926072
23	WNK4	1.42412728
24	GRK1	1.36895812
25	PAK3	1.35737323
26	BCKDK	1.30845513
27	OXSR1	1.30737647
28	FGFR2	1.29048554
29	MAP3K9	1.26942850
30	SIK2	1.26556022
31	PLK2	1.25683037
32	TSSK6	1.23242637
33	TXK	1.19706524
34	INSRR	1.17836405
35	DYRK3	1.13693653
36	STK39	1.10115730
37	MKNK1	1.08674905
38	TLK1	1.05524580
39	PNCK	1.05409400
40	SGK2	0.99477219
41	CDK3	0.98347993
42	DYRK2	0.97470084
43	PTK2B	0.95211565
44	PRKCE	0.95126671
45	EPHA4	0.91454091
46	MAPK15	0.88883485
47	EPHA3	0.88092808
48	MST4	0.87186815
49	CSNK1A1L	0.86862140
50	NTRK3	0.85523694
51	NEK2	0.83098173
52	SRPK1	0.81597514
53	CSNK1G1	0.81169137
54	PLK4	0.80584721
55	CSNK1G2	0.77994398
56	BRSK2	0.77020626
57	NEK1	0.73800730
58	MUSK	0.73374862
59	CAMKK2	0.72576936
60	EIF2AK3	0.71715332
61	NTRK2	0.68367771
62	ADRBK1	0.66480807
63	SGK223	0.66353477
64	SGK494	0.66353477
65	TEC	0.65021063
66	DAPK2	0.64840934
67	PRKCG	0.63704986
68	FLT3	0.62784820
69	CSNK1G3	0.62443657
70	PKN1	0.61731269
71	RPS6KA4	0.57920889
72	WEE1	0.57332149
73	MINK1	0.56939668
74	SIK3	0.56662191
75	IRAK1	0.53605445
76	NLK	0.53244689
77	MAP2K7	0.50294964
78	PLK3	0.49484590
79	TGFBR1	0.48450049
80	CAMK1D	0.47646135
81	DYRK1A	0.47497440
82	CAMK2A	0.47231111
83	CHUK	0.46005997
84	IKBKB	0.45352148
85	CAMK1G	0.43535047
86	EPHB2	0.41464935
87	RPS6KA5	0.41324876
88	CDK19	0.40600519
89	CSNK1D	0.39742092
90	PRKACA	0.38785747
91	PHKG1	0.36446965
92	PHKG2	0.36446965
93	CAMK1	0.36106423
94	CSNK1A1	0.35564919
95	CSNK1E	0.35163346
96	CAMK4	0.34570337
97	OBSCN	0.33709410
98	SGK1	0.33183996
99	BRD4	0.32995746
100	FER	0.32338702

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.24548026
2	Phototransduction_Homo sapiens_hsa04744	3.03229747
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.82263273
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.48808926
5	Butanoate metabolism_Homo sapiens_hsa00650	2.48459557
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.47798640
7	Protein export_Homo sapiens_hsa03060	2.45951769
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.45665227
9	Basal transcription factors_Homo sapiens_hsa03022	2.26409609
10	Nicotine addiction_Homo sapiens_hsa05033	2.25834733
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12536546
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.02275792
13	Propanoate metabolism_Homo sapiens_hsa00640	2.00191263
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.97304368
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.96825421
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.91297484
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.89217241
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.86964322
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66352905
20	RNA degradation_Homo sapiens_hsa03018	1.65003886
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.60949316
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.59302582
23	Taste transduction_Homo sapiens_hsa04742	1.47416550
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46038339
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40208460
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36252857
27	Circadian rhythm_Homo sapiens_hsa04710	1.32700368
28	ABC transporters_Homo sapiens_hsa02010	1.26545102
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.25194644
30	Peroxisome_Homo sapiens_hsa04146	1.23048533
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22417256
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.19366413
33	Parkinsons disease_Homo sapiens_hsa05012	1.16766428
34	Olfactory transduction_Homo sapiens_hsa04740	1.13410513
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12698469
36	Caffeine metabolism_Homo sapiens_hsa00232	1.11605409
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11126693
38	Retinol metabolism_Homo sapiens_hsa00830	1.08780329
39	Morphine addiction_Homo sapiens_hsa05032	1.08324289
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.07302413
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.06778809
42	RNA polymerase_Homo sapiens_hsa03020	1.04785253
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.02576097
44	Regulation of autophagy_Homo sapiens_hsa04140	1.01347747
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00670935
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.99852959
47	Homologous recombination_Homo sapiens_hsa03440	0.99455651
48	Cocaine addiction_Homo sapiens_hsa05030	0.97717813
49	Huntingtons disease_Homo sapiens_hsa05016	0.94972360
50	Insulin secretion_Homo sapiens_hsa04911	0.94210586
51	Circadian entrainment_Homo sapiens_hsa04713	0.92444521
52	Serotonergic synapse_Homo sapiens_hsa04726	0.90207400
53	GABAergic synapse_Homo sapiens_hsa04727	0.88563599
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81283965
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.80925959
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80805052
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79754165
58	Salivary secretion_Homo sapiens_hsa04970	0.79402820
59	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.78242723
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77334583
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76981470
62	Lysine degradation_Homo sapiens_hsa00310	0.76585907
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75350657
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.74261881
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71191010
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67976505
67	Alzheimers disease_Homo sapiens_hsa05010	0.60491536
68	Axon guidance_Homo sapiens_hsa04360	0.59659247
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59646885
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59248232
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.59051765
72	Long-term depression_Homo sapiens_hsa04730	0.59035186
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.58528884
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58034951
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53601970
76	Purine metabolism_Homo sapiens_hsa00230	0.53308486
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53265859
78	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52744170
79	Amphetamine addiction_Homo sapiens_hsa05031	0.52124746
80	Sulfur metabolism_Homo sapiens_hsa00920	0.51315762
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48968829
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48114609
83	Metabolic pathways_Homo sapiens_hsa01100	0.46588853
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46436545
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.46366686
86	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.41243567
87	Cholinergic synapse_Homo sapiens_hsa04725	0.41031368
88	RNA transport_Homo sapiens_hsa03013	0.40942628
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.40363308
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38737128
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.37630778
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35037171
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33951926
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33599245
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33471712
96	p53 signaling pathway_Homo sapiens_hsa04115	0.33359721
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33073701
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.30774699
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.30382887
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.29515529

ZNF432

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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