ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.07736144
2	regulation of cAMP-dependent protein kinase activity (GO:2000479)	4.03565415
3	presynaptic membrane assembly (GO:0097105)	3.72671940
4	axonal fasciculation (GO:0007413)	3.48154137
5	presynaptic membrane organization (GO:0097090)	3.19790352
6	neuron recognition (GO:0008038)	3.16991351
7	postsynaptic membrane organization (GO:0001941)	3.09879521
8	retina vasculature morphogenesis in camera-type eye (GO:0061299)	3.08395937
9	nucleobase catabolic process (GO:0046113)	3.01283694
10	cardiac myofibril assembly (GO:0055003)	2.98043830
11	negative regulation of protein localization to cell surface (GO:2000009)	2.95500409
12	neuron cell-cell adhesion (GO:0007158)	2.93955124
13	regulation of sarcomere organization (GO:0060297)	2.84226190
14	cerebral cortex radially oriented cell migration (GO:0021799)	2.82387831
15	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.81525743
16	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.81036052
17	membrane assembly (GO:0071709)	2.75246513
18	layer formation in cerebral cortex (GO:0021819)	2.71742455
19	dendrite morphogenesis (GO:0048813)	2.70157161
20	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.63414986
21	Notch signaling involved in heart development (GO:0061314)	2.57799518
22	endocardial cushion morphogenesis (GO:0003203)	2.53078019
23	C4-dicarboxylate transport (GO:0015740)	2.51888578
24	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.51582259
25	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.50280410
26	myofibril assembly (GO:0030239)	2.47728872
27	vocalization behavior (GO:0071625)	2.47248709
28	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.44037046
29	positive regulation of muscle hypertrophy (GO:0014742)	2.41907716
30	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.41907716
31	carnitine shuttle (GO:0006853)	2.38090932
32	central nervous system projection neuron axonogenesis (GO:0021952)	2.37612769
33	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.35339774
34	cardiac chamber formation (GO:0003207)	2.32119661
35	synapse assembly (GO:0007416)	2.31685309
36	regulation of axon extension involved in axon guidance (GO:0048841)	2.31014446
37	positive regulation of synapse assembly (GO:0051965)	2.30829765
38	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.30284517
39	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.29723198
40	auditory behavior (GO:0031223)	2.28581141
41	cardiac ventricle formation (GO:0003211)	2.26399146
42	collagen fibril organization (GO:0030199)	2.26106533
43	dermatan sulfate biosynthetic process (GO:0030208)	2.26049635
44	regulation of transforming growth factor beta2 production (GO:0032909)	2.25430582
45	gamma-aminobutyric acid transport (GO:0015812)	2.23970103
46	mesenchyme morphogenesis (GO:0072132)	2.23929093
47	myotube differentiation (GO:0014902)	2.22601379
48	cerebral cortex cell migration (GO:0021795)	2.21758618
49	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.21528575
50	regulation of cardiac muscle hypertrophy (GO:0010611)	2.20577300
51	regulation of synapse assembly (GO:0051963)	2.18804217
52	axon extension (GO:0048675)	2.18264982
53	regulation of muscle hypertrophy (GO:0014743)	2.16243866
54	lens morphogenesis in camera-type eye (GO:0002089)	2.16164583
55	morphogenesis of an epithelial sheet (GO:0002011)	2.15846637
56	regulation of relaxation of muscle (GO:1901077)	2.14882184
57	apical protein localization (GO:0045176)	2.14557996
58	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.14167049
59	head development (GO:0060322)	2.13761292
60	cell communication by electrical coupling (GO:0010644)	2.12905579
61	regulation of axon guidance (GO:1902667)	2.12313136
62	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.11456661
63	limb bud formation (GO:0060174)	2.11339493
64	establishment of nucleus localization (GO:0040023)	2.10226660
65	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.09771955
66	nucleus localization (GO:0051647)	2.09154659
67	regulation of skeletal muscle cell differentiation (GO:2001014)	2.08476198
68	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.08274310
69	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)	2.08161080
70	astrocyte development (GO:0014002)	2.08069937
71	L-serine transport (GO:0015825)	2.07967477
72	establishment of mitochondrion localization (GO:0051654)	2.07840379
73	protein localization to synapse (GO:0035418)	2.07652564
74	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.07412448
75	ephrin receptor signaling pathway (GO:0048013)	2.07384833
76	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.07072991
77	negative regulation of neurotransmitter secretion (GO:0046929)	2.06427216
78	synapse organization (GO:0050808)	2.05706205
79	myoblast fusion (GO:0007520)	2.05621423
80	heart valve morphogenesis (GO:0003179)	2.05222526
81	peripheral nervous system axon ensheathment (GO:0032292)	2.04408858
82	myelination in peripheral nervous system (GO:0022011)	2.04408858
83	regulation of cardiac muscle cell differentiation (GO:2000725)	2.04300995
84	dermatan sulfate metabolic process (GO:0030205)	2.04299012
85	extracellular fibril organization (GO:0043206)	2.02710917
86	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.02691442
87	positive regulation of potassium ion transport (GO:0043268)	2.02519344
88	regulation of synaptic vesicle exocytosis (GO:2000300)	2.02247987
89	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.02152517
90	regulation of glycogen (starch) synthase activity (GO:2000465)	2.01448907
91	neurotransmitter-gated ion channel clustering (GO:0072578)	2.00555006
92	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.00412173
93	response to auditory stimulus (GO:0010996)	2.00300382
94	nerve growth factor signaling pathway (GO:0038180)	2.00088518
95	cellular response to catecholamine stimulus (GO:0071870)	1.99978821
96	cellular response to monoamine stimulus (GO:0071868)	1.99978821
97	fatty acid transmembrane transport (GO:1902001)	1.99906651
98	heart valve formation (GO:0003188)	1.98832179
99	fatty acid elongation (GO:0030497)	1.98739455
100	asymmetric protein localization (GO:0008105)	1.98722751

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.80663096
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.19723049
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.77646715
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.69995474
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50653752
6	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.46200725
7	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.39665233
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.30442519
9	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.25523039
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.25014576
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.11790667
12	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.00396861
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91976685
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.89964389
15	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.89715502
16	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.89405932
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.86615701
18	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.85692789
19	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.85113973
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.84151004
21	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.81333651
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.78968713
23	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.77806823
24	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.74191186
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.72620712
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.71643313
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71338229
28	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.71016305
29	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.71016305
30	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.67205047
31	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.67205047
32	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.67001662
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66799935
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66544939
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.64481184
36	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.63858049
37	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.61586352
38	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60944366
39	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.59979100
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59421021
41	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.57997590
42	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.54111179
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.52161255
44	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.49271214
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48531243
46	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.47324627
47	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.44284874
48	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.43650430
49	TP53_16413492_ChIP-PET_HCT116_Human	1.40289263
50	CJUN_26792858_Chip-Seq_BT549_Human	1.38261047
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36335092
52	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35632667
53	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.34529506
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33224735
55	FUS_26573619_Chip-Seq_HEK293_Human	1.33139321
56	TP53_18474530_ChIP-ChIP_U2OS_Human	1.32583157
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31827710
58	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.30647498
59	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.30281331
60	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.30265263
61	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.29907034
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29606840
63	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.27599935
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.27300734
65	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26177545
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25528218
67	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25162783
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25081269
69	STAT3_23295773_ChIP-Seq_U87_Human	1.24798273
70	P300_19829295_ChIP-Seq_ESCs_Human	1.23320662
71	AHR_22903824_ChIP-Seq_MCF-7_Human	1.22770286
72	AR_21572438_ChIP-Seq_LNCaP_Human	1.22306986
73	ZNF274_21170338_ChIP-Seq_K562_Hela	1.21332944
74	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.17842457
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17649294
76	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.16865604
77	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16504034
78	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.15874342
79	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.14650246
80	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.12093959
81	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.12090240
82	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.11292603
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10642202
84	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.10146730
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10117405
86	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09032047
87	EWS_26573619_Chip-Seq_HEK293_Human	1.08359438
88	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.07612472
89	KDM2B_26808549_Chip-Seq_REH_Human	1.06908555
90	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.03926641
91	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.03297349
92	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00673140
93	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99594949
94	AR_25329375_ChIP-Seq_VCAP_Human	0.99463132
95	TCF4_23295773_ChIP-Seq_U87_Human	0.99403771
96	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.98666833
97	* AR_19668381_ChIP-Seq_PC3_Human	0.97917175
98	CBP_20019798_ChIP-Seq_JUKART_Human	0.97904070
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97904070
100	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.97359259

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	3.42103796
2	MP0005275_abnormal_skin_tensile	3.14070385
3	MP0004270_analgesia	2.72667007
4	MP0000751_myopathy	2.56482369
5	MP0004272_abnormal_basement_membrane	2.47212092
6	MP0004859_abnormal_synaptic_plasticity	2.37947297
7	MP0010368_abnormal_lymphatic_system	2.36703584
8	MP0005503_abnormal_tendon_morphology	2.28789343
9	MP0005248_abnormal_Harderian_gland	2.16055589
10	MP0000778_abnormal_nervous_system	2.00535618
11	MP0001879_abnormal_lymphatic_vessel	1.99129635
12	MP0000537_abnormal_urethra_morphology	1.85778908
13	MP0005187_abnormal_penis_morphology	1.78013587
14	MP0010386_abnormal_urinary_bladder	1.74038483
15	MP0004145_abnormal_muscle_electrophysio	1.57926968
16	MP0000462_abnormal_digestive_system	1.57758799
17	MP0005367_renal/urinary_system_phenotyp	1.52981175
18	MP0000516_abnormal_urinary_system	1.52981175
19	MP0003705_abnormal_hypodermis_morpholog	1.48664058
20	MP0002108_abnormal_muscle_morphology	1.47627792
21	MP0002822_catalepsy	1.45810686
22	MP0001984_abnormal_olfaction	1.45712433
23	MP0000749_muscle_degeneration	1.44435465
24	MP0002734_abnormal_mechanical_nocicepti	1.42159334
25	MP0000534_abnormal_ureter_morphology	1.41508161
26	MP0001270_distended_abdomen	1.40728917
27	MP0001958_emphysema	1.39635934
28	MP0004885_abnormal_endolymph	1.36947176
29	MP0004084_abnormal_cardiac_muscle	1.34861845
30	MP0001299_abnormal_eye_distance/	1.34205712
31	MP0002735_abnormal_chemical_nociception	1.32797652
32	MP0002638_abnormal_pupillary_reflex	1.32677274
33	MP0000013_abnormal_adipose_tissue	1.32055463
34	MP0003635_abnormal_synaptic_transmissio	1.28490595
35	MP0002233_abnormal_nose_morphology	1.28271284
36	MP0003385_abnormal_body_wall	1.26856681
37	MP0002234_abnormal_pharynx_morphology	1.23671594
38	MP0003880_abnormal_central_pattern	1.23023332
39	MP0001502_abnormal_circadian_rhythm	1.21847564
40	MP0002896_abnormal_bone_mineralization	1.19173314
41	MP0005623_abnormal_meninges_morphology	1.17864770
42	MP0001177_atelectasis	1.17745507
43	MP0003935_abnormal_craniofacial_develop	1.15890036
44	MP0003279_aneurysm	1.15861776
45	MP0004233_abnormal_muscle_weight	1.14894010
46	MP0009384_cardiac_valve_regurgitation	1.11874984
47	MP0003122_maternal_imprinting	1.11811447
48	MP0004215_abnormal_myocardial_fiber	1.10951366
49	MP0003755_abnormal_palate_morphology	1.10747303
50	MP0003300_gastrointestinal_ulcer	1.10634849
51	MP0000762_abnormal_tongue_morphology	1.10170860
52	MP0003941_abnormal_skin_development	1.10146970
53	MP0000383_abnormal_hair_follicle	1.08839609
54	MP0005595_abnormal_vascular_smooth	1.08715358
55	MP0005620_abnormal_muscle_contractility	1.06078277
56	MP0002063_abnormal_learning/memory/cond	1.05976848
57	MP0002282_abnormal_trachea_morphology	1.05724399
58	MP0003942_abnormal_urinary_system	1.02768964
59	MP0000049_abnormal_middle_ear	1.02581102
60	MP0003329_amyloid_beta_deposits	0.99677964
61	MP0005171_absent_coat_pigmentation	0.98783680
62	MP0000767_abnormal_smooth_muscle	0.95482670
63	MP0006276_abnormal_autonomic_nervous	0.95144492
64	MP0009250_abnormal_appendicular_skeleto	0.94546393
65	MP0003283_abnormal_digestive_organ	0.92911151
66	MP0010678_abnormal_skin_adnexa	0.91829818
67	MP0002928_abnormal_bile_duct	0.88076262
68	MP0002971_abnormal_brown_adipose	0.87392097
69	MP0002697_abnormal_eye_size	0.85641986
70	MP0000733_abnormal_muscle_development	0.84579067
71	MP0004130_abnormal_muscle_cell	0.83845719
72	MP0003121_genomic_imprinting	0.83116483
73	MP0002127_abnormal_cardiovascular_syste	0.81800582
74	MP0008789_abnormal_olfactory_epithelium	0.80365614
75	MP0000747_muscle_weakness	0.79028458
76	MP0004087_abnormal_muscle_fiber	0.79017120
77	MP0005409_darkened_coat_color	0.78797476
78	MP0002249_abnormal_larynx_morphology	0.78592324
79	MP0002972_abnormal_cardiac_muscle	0.77918705
80	MP0006054_spinal_hemorrhage	0.77751750
81	MP0001486_abnormal_startle_reflex	0.77735981
82	MP0004811_abnormal_neuron_physiology	0.77614857
83	MP0003634_abnormal_glial_cell	0.76843036
84	MP0005220_abnormal_exocrine_pancreas	0.75896444
85	MP0000566_synostosis	0.75859361
86	MP0001968_abnormal_touch/_nociception	0.75684890
87	MP0001529_abnormal_vocalization	0.74649622
88	MP0000613_abnormal_salivary_gland	0.74621077
89	MP0005394_taste/olfaction_phenotype	0.74433751
90	MP0005499_abnormal_olfactory_system	0.74433751
91	MP0002882_abnormal_neuron_morphology	0.74156543
92	MP0002272_abnormal_nervous_system	0.73958337
93	MP0005508_abnormal_skeleton_morphology	0.73272912
94	MP0005369_muscle_phenotype	0.73220065
95	MP0008775_abnormal_heart_ventricle	0.72932276
96	MP0005423_abnormal_somatic_nervous	0.72294958
97	MP0003937_abnormal_limbs/digits/tail_de	0.72059073
98	MP0008569_lethality_at_weaning	0.71791724
99	MP0004036_abnormal_muscle_relaxation	0.71500708
100	MP0003091_abnormal_cell_migration	0.71325553

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Vertebral arch anomaly (HP:0008438)	3.92867878
2	Arterial tortuosity (HP:0005116)	3.47501549
3	Vascular tortuosity (HP:0004948)	3.33953018
4	Mitral stenosis (HP:0001718)	3.23419774
5	Papillary thyroid carcinoma (HP:0002895)	2.71983902
6	Aortic dissection (HP:0002647)	2.59427097
7	Protrusio acetabuli (HP:0003179)	2.57177008
8	Pulmonary artery stenosis (HP:0004415)	2.56755870
9	Limited hip movement (HP:0008800)	2.56423293
10	Abnormality of the calf musculature (HP:0001430)	2.49433497
11	Ulnar bowing (HP:0003031)	2.41723033
12	Neonatal short-limb short stature (HP:0008921)	2.41593904
13	Soft skin (HP:0000977)	2.38974801
14	Small epiphyses (HP:0010585)	2.37234760
15	Atrophic scars (HP:0001075)	2.34581581
16	Infantile muscular hypotonia (HP:0008947)	2.34217403
17	Drooling (HP:0002307)	2.29255970
18	Pulmonic stenosis (HP:0001642)	2.24101461
19	Split foot (HP:0001839)	2.20443594
20	Arthropathy (HP:0003040)	2.20051972
21	Hypoplasia of the iris (HP:0007676)	2.18430900
22	Cubitus valgus (HP:0002967)	2.17597106
23	Absent speech (HP:0001344)	2.15987365
24	Action tremor (HP:0002345)	2.14497604
25	Pheochromocytoma (HP:0002666)	2.12203884
26	Cutaneous finger syndactyly (HP:0010554)	2.05090950
27	Aortic aneurysm (HP:0004942)	2.04494733
28	Excessive salivation (HP:0003781)	2.03675489
29	Premature rupture of membranes (HP:0001788)	2.02922139
30	Morphological abnormality of the middle ear (HP:0008609)	2.02807822
31	Bladder diverticulum (HP:0000015)	2.02247481
32	Mitral regurgitation (HP:0001653)	2.01026999
33	Retinal dysplasia (HP:0007973)	2.00229271
34	Overgrowth (HP:0001548)	1.97402788
35	Calf muscle hypertrophy (HP:0008981)	1.97334588
36	Vertebral clefting (HP:0008428)	1.97112164
37	Widely spaced teeth (HP:0000687)	1.93494896
38	Gait imbalance (HP:0002141)	1.91221601
39	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.91198686
40	Turricephaly (HP:0000262)	1.90477067
41	Aortic regurgitation (HP:0001659)	1.90422368
42	Tubulointerstitial nephritis (HP:0001970)	1.90397930
43	Neuroendocrine neoplasm (HP:0100634)	1.89891872
44	Tibial bowing (HP:0002982)	1.88564346
45	Neoplasm of the heart (HP:0100544)	1.87969670
46	Subaortic stenosis (HP:0001682)	1.86440111
47	Abnormality of the left ventricular outflow tract (HP:0011103)	1.86440111
48	Hemiparesis (HP:0001269)	1.82116349
49	Lower limb muscle weakness (HP:0007340)	1.81238019
50	Spinal rigidity (HP:0003306)	1.80481215
51	Cutaneous syndactyly (HP:0012725)	1.80367526
52	Exercise-induced myalgia (HP:0003738)	1.78633868
53	Abnormality of the lower motor neuron (HP:0002366)	1.78482639
54	Genital tract atresia (HP:0001827)	1.78262794
55	Sudden death (HP:0001699)	1.76711750
56	Vaginal atresia (HP:0000148)	1.75198088
57	Striae distensae (HP:0001065)	1.74643496
58	Abnormality of the ischium (HP:0003174)	1.73051743
59	Polyphagia (HP:0002591)	1.72373526
60	Megalencephaly (HP:0001355)	1.71671722
61	Open mouth (HP:0000194)	1.69575053
62	Hyporeflexia of lower limbs (HP:0002600)	1.69399949
63	Amyotrophic lateral sclerosis (HP:0007354)	1.68905240
64	Congenital primary aphakia (HP:0007707)	1.68645210
65	Flattened epiphyses (HP:0003071)	1.68385227
66	Muscle hypertrophy of the lower extremities (HP:0008968)	1.68289618
67	Ankle clonus (HP:0011448)	1.66546538
68	Atonic seizures (HP:0010819)	1.66288718
69	Medial flaring of the eyebrow (HP:0010747)	1.65876986
70	Mitral valve prolapse (HP:0001634)	1.65560914
71	Subacute progressive viral hepatitis (HP:0006572)	1.65241810
72	Aplasia involving bones of the upper limbs (HP:0009823)	1.64077880
73	Aplasia of the phalanges of the hand (HP:0009802)	1.64077880
74	Aplasia involving bones of the extremities (HP:0009825)	1.64077880
75	Follicular hyperkeratosis (HP:0007502)	1.63507012
76	Hypoplastic pelvis (HP:0008839)	1.62566050
77	Steppage gait (HP:0003376)	1.62520923
78	Metatarsus adductus (HP:0001840)	1.62419191
79	Neoplasm of the peripheral nervous system (HP:0100007)	1.62414188
80	Knee flexion contracture (HP:0006380)	1.61102296
81	Aortic valve stenosis (HP:0001650)	1.60173956
82	Absent eyelashes (HP:0000561)	1.59019777
83	Distal arthrogryposis (HP:0005684)	1.58977150
84	Large earlobe (HP:0009748)	1.58528584
85	Wrist flexion contracture (HP:0001239)	1.57842304
86	Male infertility (HP:0003251)	1.57822275
87	Increased variability in muscle fiber diameter (HP:0003557)	1.57563101
88	Decreased lacrimation (HP:0000633)	1.57540573
89	Exercise-induced muscle cramps (HP:0003710)	1.56582494
90	Renal dysplasia (HP:0000110)	1.56407760
91	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.56314962
92	Absent frontal sinuses (HP:0002688)	1.56210253
93	Chronic hepatic failure (HP:0100626)	1.55975222
94	Hyperextensible skin (HP:0000974)	1.54051286
95	Exotropia (HP:0000577)	1.53625414
96	Alopecia of scalp (HP:0002293)	1.52882014
97	Abnormality of the right ventricle (HP:0001707)	1.50225653
98	Round ear (HP:0100830)	1.49116089
99	Lower limb asymmetry (HP:0100559)	1.49045965
100	Hip contracture (HP:0003273)	1.48173837

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LMTK2	5.25710736
2	MARK1	3.97439708
3	CASK	3.78220563
4	BCR	2.55213500
5	EPHB2	2.35443432
6	PDGFRA	2.31396907
7	AKT3	2.30658700
8	MAP3K4	1.89373268
9	EPHA3	1.86231191
10	ERBB3	1.84097468
11	NTRK2	1.72407130
12	EPHA4	1.68839413
13	OBSCN	1.67591096
14	CSNK1G2	1.63529794
15	NTRK1	1.54508520
16	FER	1.50972718
17	MAPK13	1.48628216
18	NTRK3	1.42666299
19	CSNK1A1L	1.40749122
20	LATS1	1.38838529
21	MAP2K7	1.33274803
22	DMPK	1.32460750
23	PDGFRB	1.28453969
24	TNIK	1.26387267
25	CCNB1	1.20135513
26	CSNK1G3	1.16079236
27	CSNK1G1	1.14857993
28	SGK2	1.11854328
29	NEK9	1.10907635
30	MAPKAPK5	1.09496514
31	PIK3CA	1.06013463
32	PHKG2	1.04717064
33	PHKG1	1.04717064
34	MAP3K6	1.03398360
35	RIPK1	1.02060637
36	PKN2	1.01052312
37	PRKCE	0.97149442
38	TRIM28	0.94647844
39	MET	0.94616414
40	PAK6	0.94056413
41	SGK494	0.90179831
42	SGK223	0.90179831
43	DDR2	0.89417646
44	ROCK1	0.89139815
45	MAP4K2	0.87866373
46	CDK5	0.85298488
47	PINK1	0.83920090
48	UHMK1	0.82877392
49	MOS	0.75690413
50	DYRK2	0.74652465
51	SGK3	0.74317898
52	ROCK2	0.73858249
53	PRKAA1	0.73559965
54	LATS2	0.72002500
55	BMPR1B	0.70971902
56	MAP2K4	0.67153794
57	DYRK1B	0.65995922
58	TYRO3	0.65982393
59	CAMK2B	0.65980624
60	MAP3K2	0.63362309
61	PTK2	0.62975502
62	CAMK2A	0.62974282
63	MINK1	0.62531951
64	TIE1	0.62407481
65	MAPK7	0.62371133
66	CAMK2D	0.62273035
67	STK38L	0.61757322
68	RAF1	0.61593875
69	ERBB4	0.57935902
70	BCKDK	0.57021480
71	PNCK	0.56910588
72	LIMK1	0.56380540
73	SIK2	0.55045054
74	WNK3	0.54127306
75	DYRK1A	0.53860879
76	MAPK10	0.52502292
77	KSR1	0.52080179
78	RET	0.51989720
79	MAP3K7	0.50878396
80	PAK2	0.49538323
81	RPS6KA2	0.49238754
82	PRKD1	0.48248615
83	PRKACB	0.47059667
84	PAK3	0.46908566
85	FGFR1	0.46695840
86	YES1	0.45733201
87	PRKCZ	0.45527806
88	RPS6KB1	0.44976005
89	SRPK1	0.44968647
90	NEK6	0.44096689
91	PKN1	0.43483316
92	PRKG1	0.43360441
93	GSK3A	0.42936209
94	CAMK2G	0.42776118
95	PLK2	0.41196697
96	CSNK1D	0.40918925
97	PRKG2	0.40869688
98	PRKAA2	0.40115336
99	DYRK3	0.39766256
100	CAMK1G	0.39440555

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.18440323
2	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.04792779
3	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.00706554
4	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.89799577
5	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.88908245
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.88895158
7	ECM-receptor interaction_Homo sapiens_hsa04512	1.88224843
8	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.84660408
9	Nicotine addiction_Homo sapiens_hsa05033	1.79314438
10	Circadian rhythm_Homo sapiens_hsa04710	1.63808114
11	Axon guidance_Homo sapiens_hsa04360	1.50500553
12	Circadian entrainment_Homo sapiens_hsa04713	1.49302787
13	GABAergic synapse_Homo sapiens_hsa04727	1.46701707
14	Cocaine addiction_Homo sapiens_hsa05030	1.42354229
15	Focal adhesion_Homo sapiens_hsa04510	1.35971349
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.34051956
17	Dopaminergic synapse_Homo sapiens_hsa04728	1.32796974
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.32395457
19	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.31225587
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.28577166
21	AMPK signaling pathway_Homo sapiens_hsa04152	1.26643161
22	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.26117007
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.24925342
24	Gap junction_Homo sapiens_hsa04540	1.24528076
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.18130217
26	Amphetamine addiction_Homo sapiens_hsa05031	1.17992926
27	Phenylalanine metabolism_Homo sapiens_hsa00360	1.16494217
28	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.12325733
29	Long-term depression_Homo sapiens_hsa04730	1.08471933
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06291744
31	Hippo signaling pathway_Homo sapiens_hsa04390	1.05188958
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.04846563
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.04500722
34	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.01351954
35	Renin secretion_Homo sapiens_hsa04924	1.00084752
36	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.98396100
37	Endometrial cancer_Homo sapiens_hsa05213	0.98131954
38	Protein digestion and absorption_Homo sapiens_hsa04974	0.97418619
39	Propanoate metabolism_Homo sapiens_hsa00640	0.96974919
40	Adherens junction_Homo sapiens_hsa04520	0.96329617
41	Morphine addiction_Homo sapiens_hsa05032	0.93708015
42	Glioma_Homo sapiens_hsa05214	0.92247319
43	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.92080911
44	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.91814225
45	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.91364454
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89188336
47	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.88779351
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.88723535
49	Cholinergic synapse_Homo sapiens_hsa04725	0.88438537
50	cAMP signaling pathway_Homo sapiens_hsa04024	0.87515646
51	Gastric acid secretion_Homo sapiens_hsa04971	0.87466902
52	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.85452033
53	Basal cell carcinoma_Homo sapiens_hsa05217	0.85147509
54	Type II diabetes mellitus_Homo sapiens_hsa04930	0.83907521
55	Estrogen signaling pathway_Homo sapiens_hsa04915	0.83670390
56	Melanogenesis_Homo sapiens_hsa04916	0.81875378
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.81606129
58	ErbB signaling pathway_Homo sapiens_hsa04012	0.80373040
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.79951995
60	MicroRNAs in cancer_Homo sapiens_hsa05206	0.79437511
61	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.79363993
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78616358
63	Insulin signaling pathway_Homo sapiens_hsa04910	0.78555092
64	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.76544305
65	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.75634263
66	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.74927202
67	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.74899551
68	Long-term potentiation_Homo sapiens_hsa04720	0.74666523
69	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.74047475
70	Fatty acid elongation_Homo sapiens_hsa00062	0.73063803
71	Proteoglycans in cancer_Homo sapiens_hsa05205	0.71973151
72	Renal cell carcinoma_Homo sapiens_hsa05211	0.71747276
73	Tight junction_Homo sapiens_hsa04530	0.71503916
74	Insulin secretion_Homo sapiens_hsa04911	0.71261495
75	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.70977068
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69557462
77	Vibrio cholerae infection_Homo sapiens_hsa05110	0.68662916
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.68548406
79	Rap1 signaling pathway_Homo sapiens_hsa04015	0.68410891
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.67752313
81	Ras signaling pathway_Homo sapiens_hsa04014	0.67126285
82	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.66435281
83	Salivary secretion_Homo sapiens_hsa04970	0.65534967
84	ABC transporters_Homo sapiens_hsa02010	0.63416538
85	Melanoma_Homo sapiens_hsa05218	0.62302036
86	Amoebiasis_Homo sapiens_hsa05146	0.61842906
87	Colorectal cancer_Homo sapiens_hsa05210	0.60959088
88	mTOR signaling pathway_Homo sapiens_hsa04150	0.60940105
89	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.57740270
90	Butanoate metabolism_Homo sapiens_hsa00650	0.56558354
91	Histidine metabolism_Homo sapiens_hsa00340	0.56050464
92	GnRH signaling pathway_Homo sapiens_hsa04912	0.54674538
93	Prostate cancer_Homo sapiens_hsa05215	0.53593564
94	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.52748870
95	Prolactin signaling pathway_Homo sapiens_hsa04917	0.50544909
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.50049857
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.49747407
98	Bile secretion_Homo sapiens_hsa04976	0.49650603
99	Insulin resistance_Homo sapiens_hsa04931	0.47837143
100	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.45961437

ZNF436

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »