ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	4.46029618
2	L-fucose metabolic process (GO:0042354)	4.46029618
3	L-fucose catabolic process (GO:0042355)	4.46029618
4	neural tube formation (GO:0001841)	4.07817590
5	negative regulation of mast cell activation (GO:0033004)	3.99227133
6	detection of light stimulus involved in sensory perception (GO:0050962)	3.64961609
7	detection of light stimulus involved in visual perception (GO:0050908)	3.64961609
8	behavioral response to nicotine (GO:0035095)	3.53143101
9	protein polyglutamylation (GO:0018095)	3.46799815
10	DNA deamination (GO:0045006)	3.33901114
11	protein K11-linked deubiquitination (GO:0035871)	3.32473088
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30627479
13	sulfation (GO:0051923)	3.21437413
14	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.09995998
15	regulation of translation, ncRNA-mediated (GO:0045974)	3.09995998
16	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.09995998
17	indolalkylamine metabolic process (GO:0006586)	3.09760421
18	neuronal action potential (GO:0019228)	3.06067156
19	response to pheromone (GO:0019236)	2.99051173
20	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.95623515
21	axoneme assembly (GO:0035082)	2.94821357
22	piRNA metabolic process (GO:0034587)	2.94536470
23	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.92861876
24	tryptophan catabolic process (GO:0006569)	2.86389105
25	indole-containing compound catabolic process (GO:0042436)	2.86389105
26	indolalkylamine catabolic process (GO:0046218)	2.86389105
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.86191269
28	nonmotile primary cilium assembly (GO:0035058)	2.86109889
29	photoreceptor cell maintenance (GO:0045494)	2.83582313
30	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82552344
31	epithelial cilium movement (GO:0003351)	2.81704338
32	regulation of cilium movement (GO:0003352)	2.80324961
33	rRNA catabolic process (GO:0016075)	2.75988292
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.73515635
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.73515635
36	NADH dehydrogenase complex assembly (GO:0010257)	2.73515635
37	regulation of glucokinase activity (GO:0033131)	2.72748297
38	regulation of hexokinase activity (GO:1903299)	2.72748297
39	interkinetic nuclear migration (GO:0022027)	2.71246142
40	tryptophan metabolic process (GO:0006568)	2.68164166
41	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.67989353
42	DNA demethylation (GO:0080111)	2.66884332
43	cAMP catabolic process (GO:0006198)	2.60068976
44	cilium or flagellum-dependent cell motility (GO:0001539)	2.59836633
45	adenosine metabolic process (GO:0046085)	2.58216778
46	dentate gyrus development (GO:0021542)	2.55204188
47	regulation of telomere maintenance (GO:0032204)	2.52913466
48	pyrimidine nucleobase catabolic process (GO:0006208)	2.52101295
49	positive regulation of granulocyte differentiation (GO:0030854)	2.51781665
50	hematopoietic stem cell proliferation (GO:0071425)	2.50965375
51	presynaptic membrane assembly (GO:0097105)	2.50311794
52	gamma-aminobutyric acid transport (GO:0015812)	2.46947369
53	activated T cell proliferation (GO:0050798)	2.46937103
54	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.46789341
55	cyclic nucleotide catabolic process (GO:0009214)	2.46329718
56	cilium morphogenesis (GO:0060271)	2.46267371
57	histone H3-K4 trimethylation (GO:0080182)	2.42611227
58	reciprocal meiotic recombination (GO:0007131)	2.40584376
59	reciprocal DNA recombination (GO:0035825)	2.40584376
60	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.40540064
61	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.40540064
62	presynaptic membrane organization (GO:0097090)	2.40369099
63	seminiferous tubule development (GO:0072520)	2.40005961
64	cellular ketone body metabolic process (GO:0046950)	2.39574264
65	positive regulation of defense response to virus by host (GO:0002230)	2.39459263
66	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.39095575
67	regulation of DNA endoreduplication (GO:0032875)	2.38901658
68	cilium organization (GO:0044782)	2.38645295
69	fucosylation (GO:0036065)	2.38186066
70	protein complex biogenesis (GO:0070271)	2.38172374
71	establishment of protein localization to Golgi (GO:0072600)	2.37054221
72	behavioral response to ethanol (GO:0048149)	2.36992563
73	photoreceptor cell development (GO:0042461)	2.36601113
74	auditory behavior (GO:0031223)	2.36099090
75	serotonin receptor signaling pathway (GO:0007210)	2.35828222
76	monoubiquitinated protein deubiquitination (GO:0035520)	2.35296035
77	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.35278547
78	cilium assembly (GO:0042384)	2.34248803
79	DNA double-strand break processing (GO:0000729)	2.33631745
80	mechanosensory behavior (GO:0007638)	2.33054380
81	mitochondrial respiratory chain complex assembly (GO:0033108)	2.32975487
82	platelet dense granule organization (GO:0060155)	2.32278399
83	mast cell degranulation (GO:0043303)	2.31916319
84	mast cell activation involved in immune response (GO:0002279)	2.31916319
85	ketone body metabolic process (GO:1902224)	2.31150213
86	histone H2A acetylation (GO:0043968)	2.29375732
87	histone H3-K9 methylation (GO:0051567)	2.28968203
88	cilium movement (GO:0003341)	2.28037275
89	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.26993444
90	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.26993444
91	positive regulation of fatty acid transport (GO:2000193)	2.26939388
92	negative regulation of telomere maintenance (GO:0032205)	2.26475508
93	membrane depolarization during action potential (GO:0086010)	2.25908570
94	regulation of action potential (GO:0098900)	2.25516356
95	positive regulation of prostaglandin secretion (GO:0032308)	2.24910401
96	dendritic spine morphogenesis (GO:0060997)	2.24598698
97	centriole replication (GO:0007099)	2.23976572
98	somite development (GO:0061053)	2.23869260
99	protein-cofactor linkage (GO:0018065)	2.23293959
100	regulation of B cell receptor signaling pathway (GO:0050855)	2.23256315

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.66847132
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.09202283
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.04410251
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.93160264
5	VDR_22108803_ChIP-Seq_LS180_Human	2.78250084
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.77885924
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.59006043
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54279654
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.52470340
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.37230204
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.30982465
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.12374949
13	FUS_26573619_Chip-Seq_HEK293_Human	2.10993825
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10779528
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00237255
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99928801
17	EWS_26573619_Chip-Seq_HEK293_Human	1.98629849
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.95457382
19	P300_19829295_ChIP-Seq_ESCs_Human	1.95223657
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.91321270
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67550172
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.67363201
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.66777463
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62322439
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.60725354
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58760821
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55700377
28	STAT3_23295773_ChIP-Seq_U87_Human	1.54636534
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.49581605
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49581605
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49490130
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49490130
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47942174
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.46426734
35	TCF4_23295773_ChIP-Seq_U87_Human	1.46175426
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.44658103
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44539587
38	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.44284495
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44034959
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42754207
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42193030
42	AR_25329375_ChIP-Seq_VCAP_Human	1.41925912
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41129245
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.40605506
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.40544336
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37026751
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35555502
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35080087
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34558978
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34463072
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33705543
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31245054
53	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.31189895
54	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28766282
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28056948
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26085974
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25279229
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23874823
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21974812
60	SCL_19346495_ChIP-Seq_HPC-7_Human	1.21222315
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20318397
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18532907
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18286878
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18286878
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17645426
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17258868
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16678089
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16274445
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16151317
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15811394
71	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14449077
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12746271
73	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.12725674
74	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.11181542
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11152568
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.10982266
77	RUNX_20019798_ChIP-Seq_JUKART_Human	1.10953613
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10548904
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08705786
80	GATA3_26560356_Chip-Seq_TH2_Human	1.08150178
81	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.08148303
82	DROSHA_22980978_ChIP-Seq_HELA_Human	1.07291121
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06672154
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06672154
85	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06590134
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.05773363
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04367090
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04345884
89	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04059558
90	AR_20517297_ChIP-Seq_VCAP_Human	1.00942535
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00910037
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99759532
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99489140
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98070760
95	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96955577
96	MYC_18940864_ChIP-ChIP_HL60_Human	0.96032743
97	NCOR_22424771_ChIP-Seq_293T_Human	0.95065374
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.94394111
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93778682
100	VDR_23849224_ChIP-Seq_CD4+_Human	0.93249436

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.66660978
2	MP0006292_abnormal_olfactory_placode	3.00191732
3	MP0003880_abnormal_central_pattern	2.53805442
4	MP0008877_abnormal_DNA_methylation	2.43985869
5	MP0005174_abnormal_tail_pigmentation	2.34328151
6	MP0005551_abnormal_eye_electrophysiolog	2.14000037
7	MP0003195_calcinosis	2.09168336
8	MP0004043_abnormal_pH_regulation	2.01249306
9	MP0003787_abnormal_imprinting	1.98016884
10	MP0002396_abnormal_hematopoietic_system	1.95371419
11	MP0002138_abnormal_hepatobiliary_system	1.95083986
12	MP0001501_abnormal_sleep_pattern	1.91274353
13	MP0001968_abnormal_touch/_nociception	1.85102722
14	MP0001986_abnormal_taste_sensitivity	1.84959953
15	MP0006072_abnormal_retinal_apoptosis	1.84343827
16	MP0004142_abnormal_muscle_tone	1.79912506
17	MP0000372_irregular_coat_pigmentation	1.78940849
18	MP0003136_yellow_coat_color	1.75558657
19	MP0000015_abnormal_ear_pigmentation	1.71352595
20	MP0006276_abnormal_autonomic_nervous	1.70713522
21	MP0002876_abnormal_thyroid_physiology	1.64959027
22	MP0002735_abnormal_chemical_nociception	1.61535641
23	MP0002102_abnormal_ear_morphology	1.59304360
24	MP0004147_increased_porphyrin_level	1.59065970
25	MP0008872_abnormal_physiological_respon	1.58704168
26	MP0005084_abnormal_gallbladder_morpholo	1.57943868
27	MP0009745_abnormal_behavioral_response	1.56256767
28	MP0002095_abnormal_skin_pigmentation	1.51999710
29	MP0002928_abnormal_bile_duct	1.46974806
30	MP0005646_abnormal_pituitary_gland	1.45950346
31	MP0005253_abnormal_eye_physiology	1.40759960
32	MP0005075_abnormal_melanosome_morpholog	1.40683990
33	MP0002653_abnormal_ependyma_morphology	1.38485281
34	MP0005645_abnormal_hypothalamus_physiol	1.36398753
35	MP0009046_muscle_twitch	1.32989552
36	MP0004885_abnormal_endolymph	1.32814116
37	MP0001800_abnormal_humoral_immune	1.30789563
38	MP0002837_dystrophic_cardiac_calcinosis	1.28957181
39	MP0003252_abnormal_bile_duct	1.28678870
40	MP0001835_abnormal_antigen_presentation	1.28569562
41	MP0002272_abnormal_nervous_system	1.27878643
42	MP0002733_abnormal_thermal_nociception	1.27324814
43	MP0001970_abnormal_pain_threshold	1.26671757
44	MP0002736_abnormal_nociception_after	1.26609139
45	MP0008007_abnormal_cellular_replicative	1.23096603
46	MP0001486_abnormal_startle_reflex	1.22269900
47	MP0001984_abnormal_olfaction	1.22087875
48	MP0005397_hematopoietic_system_phenotyp	1.16208407
49	MP0001545_abnormal_hematopoietic_system	1.16208407
50	MP0005171_absent_coat_pigmentation	1.15192518
51	MP0000427_abnormal_hair_cycle	1.12679100
52	MP0004742_abnormal_vestibular_system	1.09504903
53	MP0002572_abnormal_emotion/affect_behav	1.07562810
54	MP0010386_abnormal_urinary_bladder	1.04826268
55	MP0002277_abnormal_respiratory_mucosa	1.02120105
56	MP0000631_abnormal_neuroendocrine_gland	1.01543150
57	MP0008995_early_reproductive_senescence	1.00897783
58	MP0005220_abnormal_exocrine_pancreas	1.00894794
59	MP0002064_seizures	1.00509596
60	MP0008058_abnormal_DNA_repair	1.00427951
61	MP0004924_abnormal_behavior	0.99067358
62	MP0005386_behavior/neurological_phenoty	0.99067358
63	MP0003943_abnormal_hepatobiliary_system	0.98041054
64	MP0008875_abnormal_xenobiotic_pharmacok	0.97697525
65	MP0004808_abnormal_hematopoietic_stem	0.97499375
66	MP0004133_heterotaxia	0.96303686
67	MP0002822_catalepsy	0.94878398
68	MP0005423_abnormal_somatic_nervous	0.93830882
69	MP0002067_abnormal_sensory_capabilities	0.92735075
70	MP0003635_abnormal_synaptic_transmissio	0.91898591
71	MP0002163_abnormal_gland_morphology	0.91619622
72	MP0002557_abnormal_social/conspecific_i	0.90864714
73	MP0001485_abnormal_pinna_reflex	0.87441934
74	MP0000383_abnormal_hair_follicle	0.86931564
75	MP0002723_abnormal_immune_serum	0.86373166
76	MP0000230_abnormal_systemic_arterial	0.86173811
77	MP0000465_gastrointestinal_hemorrhage	0.83422639
78	MP0005389_reproductive_system_phenotype	0.82825752
79	MP0002229_neurodegeneration	0.82601402
80	MP0002063_abnormal_learning/memory/cond	0.81239699
81	MP0000685_abnormal_immune_system	0.81075632
82	MP0001764_abnormal_homeostasis	0.81061458
83	MP0002420_abnormal_adaptive_immunity	0.80002507
84	MP0003718_maternal_effect	0.79894446
85	MP0005195_abnormal_posterior_eye	0.79508841
86	MP0003698_abnormal_male_reproductive	0.78925808
87	MP0000689_abnormal_spleen_morphology	0.77972259
88	MP0003724_increased_susceptibility_to	0.77497696
89	MP0005367_renal/urinary_system_phenotyp	0.77436720
90	MP0000516_abnormal_urinary_system	0.77436720
91	MP0008961_abnormal_basal_metabolism	0.77186597
92	MP0001819_abnormal_immune_cell	0.77000118
93	MP0002452_abnormal_antigen_presenting	0.75860183
94	MP0004145_abnormal_muscle_electrophysio	0.74546063
95	MP0003763_abnormal_thymus_physiology	0.74070065
96	MP0005387_immune_system_phenotype	0.73658661
97	MP0001790_abnormal_immune_system	0.73658661
98	MP0005379_endocrine/exocrine_gland_phen	0.72677254
99	MP0003866_abnormal_defecation	0.71713723
100	MP0000538_abnormal_urinary_bladder	0.71399765

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.46607848
2	Molar tooth sign on MRI (HP:0002419)	4.18599645
3	Abnormality of midbrain morphology (HP:0002418)	4.18599645
4	Pancreatic cysts (HP:0001737)	4.10579658
5	True hermaphroditism (HP:0010459)	3.65877381
6	Pancreatic fibrosis (HP:0100732)	3.49743614
7	Nephronophthisis (HP:0000090)	3.31676066
8	Abnormality of the renal cortex (HP:0011035)	3.29703624
9	Abnormality of alanine metabolism (HP:0010916)	3.27586134
10	Hyperalaninemia (HP:0003348)	3.27586134
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.27586134
12	Abolished electroretinogram (ERG) (HP:0000550)	3.23137584
13	Abnormality of the renal medulla (HP:0100957)	3.08183489
14	Medial flaring of the eyebrow (HP:0010747)	3.02184787
15	Acute lymphatic leukemia (HP:0006721)	2.99757363
16	Stomach cancer (HP:0012126)	2.97492643
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.86861143
18	Hyperventilation (HP:0002883)	2.86663960
19	Renal cortical cysts (HP:0000803)	2.77515852
20	Febrile seizures (HP:0002373)	2.74718984
21	Chronic hepatic failure (HP:0100626)	2.60873833
22	Type II lissencephaly (HP:0007260)	2.60244165
23	Cystic liver disease (HP:0006706)	2.54898630
24	Broad-based gait (HP:0002136)	2.54748588
25	Progressive cerebellar ataxia (HP:0002073)	2.54641914
26	Attenuation of retinal blood vessels (HP:0007843)	2.54288000
27	Decreased central vision (HP:0007663)	2.50992828
28	Genetic anticipation (HP:0003743)	2.48498000
29	Hemiparesis (HP:0001269)	2.47152323
30	Thyroiditis (HP:0100646)	2.46035373
31	Abnormal biliary tract physiology (HP:0012439)	2.40188172
32	Bile duct proliferation (HP:0001408)	2.40188172
33	Inability to walk (HP:0002540)	2.39845909
34	Abnormality of macular pigmentation (HP:0008002)	2.37888010
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.36007839
36	Absent/shortened dynein arms (HP:0200106)	2.36007839
37	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.33612422
38	Hypoplasia of the fovea (HP:0007750)	2.33612422
39	Abnormal drinking behavior (HP:0030082)	2.31299614
40	Polydipsia (HP:0001959)	2.31299614
41	Gaze-evoked nystagmus (HP:0000640)	2.30220616
42	Gait imbalance (HP:0002141)	2.27508884
43	Widely spaced teeth (HP:0000687)	2.25627900
44	Congenital primary aphakia (HP:0007707)	2.24343192
45	Panhypogammaglobulinemia (HP:0003139)	2.23650490
46	Large for gestational age (HP:0001520)	2.23089419
47	Abnormality of B cell number (HP:0010975)	2.22957412
48	Stomatitis (HP:0010280)	2.22393274
49	Congenital hepatic fibrosis (HP:0002612)	2.20017598
50	Progressive inability to walk (HP:0002505)	2.17720935
51	Albinism (HP:0001022)	2.16594425
52	Hypothermia (HP:0002045)	2.15119422
53	Neoplasm of the adrenal cortex (HP:0100641)	2.14858967
54	Protruding tongue (HP:0010808)	2.12983380
55	Nephrogenic diabetes insipidus (HP:0009806)	2.12666797
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11502994
57	Fair hair (HP:0002286)	2.10033165
58	Severe combined immunodeficiency (HP:0004430)	2.09763544
59	Tubular atrophy (HP:0000092)	2.07484727
60	Tubulointerstitial nephritis (HP:0001970)	2.04008157
61	Abnormality of the fovea (HP:0000493)	2.03404049
62	Decreased circulating renin level (HP:0003351)	2.00416423
63	Focal motor seizures (HP:0011153)	2.00042539
64	Delayed CNS myelination (HP:0002188)	1.99419214
65	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.98949599
66	Cerebellar dysplasia (HP:0007033)	1.97365603
67	Absent speech (HP:0001344)	1.97022205
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.94616991
69	Severe visual impairment (HP:0001141)	1.92820703
70	Congenital, generalized hypertrichosis (HP:0004540)	1.92440429
71	Adactyly (HP:0009776)	1.92053233
72	Chronic sinusitis (HP:0011109)	1.91546295
73	Furrowed tongue (HP:0000221)	1.89948876
74	Elevated erythrocyte sedimentation rate (HP:0003565)	1.88499739
75	Generalized hypopigmentation of hair (HP:0011358)	1.88443238
76	Recurrent cutaneous fungal infections (HP:0011370)	1.87297803
77	Chronic mucocutaneous candidiasis (HP:0002728)	1.87297803
78	Polyuria (HP:0000103)	1.85064952
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83194883
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82317665
81	Retinal dysplasia (HP:0007973)	1.82127488
82	Anencephaly (HP:0002323)	1.81658000
83	Agammaglobulinemia (HP:0004432)	1.81130324
84	Focal seizures (HP:0007359)	1.80591201
85	Central scotoma (HP:0000603)	1.80172093
86	Bony spicule pigmentary retinopathy (HP:0007737)	1.80119849
87	Abnormal ciliary motility (HP:0012262)	1.78638182
88	Congenital sensorineural hearing impairment (HP:0008527)	1.77026575
89	Sclerocornea (HP:0000647)	1.76968778
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.76876175
91	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76876175
92	Asplenia (HP:0001746)	1.76622307
93	Poor coordination (HP:0002370)	1.75591152
94	Genital tract atresia (HP:0001827)	1.75530871
95	Constricted visual fields (HP:0001133)	1.74543257
96	Vaginal atresia (HP:0000148)	1.70872622
97	Abnormal pancreas size (HP:0012094)	1.69064696
98	Macular degeneration (HP:0000608)	1.68545561
99	Neoplasm of the tracheobronchial system (HP:0100552)	1.67472787
100	Supernumerary spleens (HP:0009799)	1.67443174

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.68557897
2	BMPR1B	2.99065276
3	TAOK3	2.79870434
4	ADRBK2	2.70638241
5	ACVR1B	2.31880246
6	PINK1	2.19460423
7	MAPK13	2.08149780
8	WNK3	2.00638255
9	KIT	1.97585690
10	INSRR	1.97057618
11	NUAK1	1.96826753
12	MAP4K2	1.86951153
13	FLT3	1.85826811
14	TXK	1.74209322
15	GRK1	1.71280869
16	ZAK	1.71203421
17	MAP4K1	1.62443578
18	DAPK2	1.58367817
19	PNCK	1.54059292
20	TEC	1.53388105
21	WNK4	1.36626206
22	CASK	1.34196883
23	PLK2	1.25460797
24	SYK	1.23319143
25	PASK	1.15898704
26	ERBB3	1.14278305
27	MARK1	1.10231460
28	ADRBK1	1.07332288
29	TGFBR1	1.06968775
30	MAP3K4	1.05826180
31	FES	1.03596964
32	TLK1	1.03536968
33	MAP3K7	1.01891595
34	CSF1R	1.01883150
35	CAMKK2	1.01678878
36	PTK2B	1.00188761
37	ITK	0.99733963
38	BMPR2	0.97794148
39	TNIK	0.94911456
40	CCNB1	0.91810842
41	IKBKB	0.91603168
42	MAPK15	0.90017178
43	FGFR2	0.88521704
44	PAK3	0.85371901
45	BRD4	0.84345647
46	MKNK2	0.84075622
47	PRKCQ	0.81289283
48	TNK2	0.80398569
49	SIK2	0.78017627
50	NTRK2	0.77773245
51	PKN1	0.77609510
52	BTK	0.75066859
53	DYRK2	0.74786340
54	PRKCE	0.74216289
55	RIPK4	0.71394569
56	CDK3	0.68900964
57	IKBKE	0.68718121
58	LYN	0.67432620
59	CAMKK1	0.66999168
60	CSNK1G2	0.65701097
61	TRPM7	0.64701838
62	STK11	0.64093761
63	LCK	0.63529461
64	VRK1	0.61844972
65	RPS6KA4	0.61701039
66	CSNK1G3	0.60368187
67	TAF1	0.59580433
68	CSNK1G1	0.58361099
69	TIE1	0.58122302
70	PRKG1	0.54584372
71	SGK2	0.53829521
72	MKNK1	0.53474660
73	OXSR1	0.53357842
74	RPS6KA5	0.51876308
75	HCK	0.51411200
76	CSNK1A1L	0.51393894
77	MAP2K6	0.50702239
78	NLK	0.49520284
79	IRAK1	0.48034976
80	GRK6	0.47830142
81	NTRK3	0.47445341
82	CHUK	0.46277750
83	MARK3	0.45487891
84	CAMK1	0.45364906
85	PIK3CA	0.43971874
86	ATR	0.43096188
87	PRKCI	0.43059959
88	BLK	0.41637256
89	RPS6KA6	0.40867038
90	PRKACA	0.40399476
91	HIPK2	0.39459911
92	BCKDK	0.39294895
93	MAP2K2	0.39265156
94	CSNK1A1	0.38780977
95	EPHA4	0.38716173
96	CAMK4	0.38528866
97	ABL1	0.36919200
98	SGK1	0.36616001
99	LATS1	0.36503401
100	JAK3	0.36490079

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.87529612
2	Phototransduction_Homo sapiens_hsa04744	2.38548749
3	Asthma_Homo sapiens_hsa05310	2.32432068
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.26309398
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.21307229
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.05031876
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.04464989
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.03794521
9	Butanoate metabolism_Homo sapiens_hsa00650	1.96595802
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93216626
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.91120722
12	Primary immunodeficiency_Homo sapiens_hsa05340	1.89604679
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.85403386
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.82696398
15	Nicotine addiction_Homo sapiens_hsa05033	1.81998008
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81674634
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.72726130
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.72291801
19	Allograft rejection_Homo sapiens_hsa05330	1.68584886
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.63481994
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.63388732
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.49109646
23	Taste transduction_Homo sapiens_hsa04742	1.48335322
24	Morphine addiction_Homo sapiens_hsa05032	1.41942176
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.40428893
26	Circadian entrainment_Homo sapiens_hsa04713	1.34875173
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.31799708
28	Insulin secretion_Homo sapiens_hsa04911	1.30758825
29	Homologous recombination_Homo sapiens_hsa03440	1.30020460
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.29271865
31	Regulation of autophagy_Homo sapiens_hsa04140	1.28718139
32	Olfactory transduction_Homo sapiens_hsa04740	1.26230404
33	Serotonergic synapse_Homo sapiens_hsa04726	1.22943288
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.18282855
35	Propanoate metabolism_Homo sapiens_hsa00640	1.15405635
36	Caffeine metabolism_Homo sapiens_hsa00232	1.09709417
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.09318905
38	Calcium signaling pathway_Homo sapiens_hsa04020	1.08555693
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.07814762
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07565403
41	Salivary secretion_Homo sapiens_hsa04970	1.06630680
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05011280
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.03333915
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01828052
45	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00616177
46	Peroxisome_Homo sapiens_hsa04146	0.99924191
47	GABAergic synapse_Homo sapiens_hsa04727	0.99100999
48	Renin secretion_Homo sapiens_hsa04924	0.97605382
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96694065
50	RNA degradation_Homo sapiens_hsa03018	0.95774042
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94330101
52	ABC transporters_Homo sapiens_hsa02010	0.93481609
53	Basal transcription factors_Homo sapiens_hsa03022	0.92804027
54	Long-term depression_Homo sapiens_hsa04730	0.92369153
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.89066368
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.85483934
57	Amphetamine addiction_Homo sapiens_hsa05031	0.84443683
58	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.84403902
59	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.83918715
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83511875
61	Dopaminergic synapse_Homo sapiens_hsa04728	0.83120320
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.82313617
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81881456
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.81248110
65	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.77434988
66	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.76167152
67	Cholinergic synapse_Homo sapiens_hsa04725	0.74943768
68	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.74671323
69	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.69400926
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.69389715
71	Protein export_Homo sapiens_hsa03060	0.68485371
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.68452922
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68060071
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66140083
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64349677
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.62356023
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60021623
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57738672
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57493715
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57286226
81	Oxidative phosphorylation_Homo sapiens_hsa00190	0.55733096
82	Leishmaniasis_Homo sapiens_hsa05140	0.54894118
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.53350936
84	Gastric acid secretion_Homo sapiens_hsa04971	0.53306428
85	Cocaine addiction_Homo sapiens_hsa05030	0.52377629
86	Pancreatic secretion_Homo sapiens_hsa04972	0.52338359
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50055889
88	Platelet activation_Homo sapiens_hsa04611	0.49915732
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49217487
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.49148424
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45921375
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44968509
93	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.44667449
94	Purine metabolism_Homo sapiens_hsa00230	0.44604972
95	Retinol metabolism_Homo sapiens_hsa00830	0.42423657
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40330415
97	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.37534093
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.37134257
99	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.36624824
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34972718

ZNF439

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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