ZNF44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.43123947
2establishment of protein localization to Golgi (GO:0072600)4.07754338
3detection of light stimulus involved in visual perception (GO:0050908)3.72635493
4detection of light stimulus involved in sensory perception (GO:0050962)3.72635493
5protein targeting to Golgi (GO:0000042)3.63113489
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.57253254
7L-fucose catabolic process (GO:0042355)3.55275057
8fucose catabolic process (GO:0019317)3.55275057
9L-fucose metabolic process (GO:0042354)3.55275057
10detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53770167
11response to pheromone (GO:0019236)3.46567884
12indolalkylamine metabolic process (GO:0006586)3.44093361
13piRNA metabolic process (GO:0034587)3.35935569
14epithelial cilium movement (GO:0003351)3.35101582
15protein K11-linked deubiquitination (GO:0035871)3.27184093
16indole-containing compound catabolic process (GO:0042436)3.23129898
17indolalkylamine catabolic process (GO:0046218)3.23129898
18tryptophan catabolic process (GO:0006569)3.23129898
19cellular ketone body metabolic process (GO:0046950)3.22990375
20behavioral response to nicotine (GO:0035095)3.22555326
21protein localization to Golgi apparatus (GO:0034067)3.22553815
22ketone body metabolic process (GO:1902224)3.20382510
23preassembly of GPI anchor in ER membrane (GO:0016254)3.18206706
24retrograde transport, vesicle recycling within Golgi (GO:0000301)3.15153511
25protein polyglutamylation (GO:0018095)3.04608680
26cilium movement (GO:0003341)3.04345927
27cilium morphogenesis (GO:0060271)3.02375926
28cilium or flagellum-dependent cell motility (GO:0001539)3.00945192
29signal peptide processing (GO:0006465)2.99759069
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.98047160
31negative regulation of translation, ncRNA-mediated (GO:0040033)2.98047160
32regulation of translation, ncRNA-mediated (GO:0045974)2.98047160
33axoneme assembly (GO:0035082)2.97407353
34platelet dense granule organization (GO:0060155)2.96853471
35protein localization to cilium (GO:0061512)2.90425586
36regulation of memory T cell differentiation (GO:0043380)2.89156811
37DNA deamination (GO:0045006)2.87169231
38tryptophan metabolic process (GO:0006568)2.87075907
39cilium organization (GO:0044782)2.86088993
40regulation of cilium movement (GO:0003352)2.84033244
41cornea development in camera-type eye (GO:0061303)2.81263086
42cilium assembly (GO:0042384)2.78703275
43regulation of meiosis I (GO:0060631)2.76412779
44mannosylation (GO:0097502)2.73556004
45phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72188637
46intraciliary transport (GO:0042073)2.70645205
47monoubiquitinated protein deubiquitination (GO:0035520)2.70598699
48kynurenine metabolic process (GO:0070189)2.68835190
49positive regulation of oligodendrocyte differentiation (GO:0048714)2.66711825
50multicellular organism reproduction (GO:0032504)2.66092944
51prenylation (GO:0097354)2.65561800
52protein prenylation (GO:0018342)2.65561800
53histone H3-K9 methylation (GO:0051567)2.64987269
54retinal cone cell development (GO:0046549)2.64410213
55tachykinin receptor signaling pathway (GO:0007217)2.63453470
56oxidative demethylation (GO:0070989)2.63251241
57presynaptic membrane assembly (GO:0097105)2.62251863
58centriole replication (GO:0007099)2.61877457
59negative regulation of mast cell activation (GO:0033004)2.61714457
60reflex (GO:0060004)2.60601660
61negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53823424
62DNA methylation involved in gamete generation (GO:0043046)2.53049948
63embryonic epithelial tube formation (GO:0001838)2.52642272
64regulation of B cell receptor signaling pathway (GO:0050855)2.51333755
65histone H3-K4 trimethylation (GO:0080182)2.50912549
66behavioral response to ethanol (GO:0048149)2.50745106
67regulation of action potential (GO:0098900)2.49193061
68photoreceptor cell maintenance (GO:0045494)2.49108224
69sperm motility (GO:0030317)2.47773900
70indole-containing compound metabolic process (GO:0042430)2.47735393
71DNA demethylation (GO:0080111)2.45808018
72cell wall macromolecule metabolic process (GO:0044036)2.45733204
73cAMP catabolic process (GO:0006198)2.43835849
74rRNA catabolic process (GO:0016075)2.42973416
75positive regulation of developmental pigmentation (GO:0048087)2.42270686
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41566735
77pyrimidine nucleobase catabolic process (GO:0006208)2.38280885
78regulation of sarcomere organization (GO:0060297)2.37722487
79gamma-aminobutyric acid transport (GO:0015812)2.37544600
80dopamine transport (GO:0015872)2.37534193
81intra-Golgi vesicle-mediated transport (GO:0006891)2.37488312
82recombinational repair (GO:0000725)2.36719649
83histone mRNA catabolic process (GO:0071044)2.35851485
84double-strand break repair via homologous recombination (GO:0000724)2.35310157
85protein K63-linked deubiquitination (GO:0070536)2.34779885
86limb bud formation (GO:0060174)2.34453620
87purinergic nucleotide receptor signaling pathway (GO:0035590)2.32657385
88cell wall macromolecule catabolic process (GO:0016998)2.32379791
89respiratory chain complex IV assembly (GO:0008535)2.31996893
90interferon-gamma production (GO:0032609)2.31882839
91neuronal action potential (GO:0019228)2.30828140
92kidney morphogenesis (GO:0060993)2.29456708
93negative regulation of systemic arterial blood pressure (GO:0003085)2.28652691
94histone H3-K9 modification (GO:0061647)2.27877247
95photoreceptor cell development (GO:0042461)2.26800421
96cellular component assembly involved in morphogenesis (GO:0010927)2.26503593
97regulation of telomere maintenance (GO:0032204)2.26256864
98nonmotile primary cilium assembly (GO:0035058)2.25909284
99epithelial tube formation (GO:0072175)2.25464898
100seminiferous tubule development (GO:0072520)2.25448690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.44767993
2VDR_22108803_ChIP-Seq_LS180_Human3.05567026
3GBX2_23144817_ChIP-Seq_PC3_Human2.93299022
4IGF1R_20145208_ChIP-Seq_DFB_Human2.85503098
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73884770
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62406987
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.38913367
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34216005
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33722782
10TAF15_26573619_Chip-Seq_HEK293_Human2.30489505
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24695480
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.16072139
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09330561
14P300_19829295_ChIP-Seq_ESCs_Human2.06402399
15FUS_26573619_Chip-Seq_HEK293_Human2.00564218
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94280683
17ER_23166858_ChIP-Seq_MCF-7_Human1.92124848
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90807927
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.88315594
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86941759
21EWS_26573619_Chip-Seq_HEK293_Human1.83574699
22BCAT_22108803_ChIP-Seq_LS180_Human1.79819784
23EZH2_22144423_ChIP-Seq_EOC_Human1.75964653
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74634627
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73831717
26AR_21572438_ChIP-Seq_LNCaP_Human1.71524937
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68266280
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66749955
29CBP_20019798_ChIP-Seq_JUKART_Human1.66749955
30SMAD4_21799915_ChIP-Seq_A2780_Human1.64991890
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.64887032
32STAT3_23295773_ChIP-Seq_U87_Human1.64165457
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59735159
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58755824
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58589547
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55523621
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.53489000
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.50990746
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49670710
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49570131
41IRF1_19129219_ChIP-ChIP_H3396_Human1.48909427
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.48554559
43TCF4_23295773_ChIP-Seq_U87_Human1.46054294
44TCF4_22108803_ChIP-Seq_LS180_Human1.44947220
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44600829
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44600829
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43793890
48AR_25329375_ChIP-Seq_VCAP_Human1.37663000
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36928204
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36458290
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35986292
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.35197209
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34758890
54SOX2_19829295_ChIP-Seq_ESCs_Human1.33791849
55NANOG_19829295_ChIP-Seq_ESCs_Human1.33791849
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.32659347
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31560491
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31366519
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30803948
60* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30763732
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29183363
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28959242
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27564132
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.27107181
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25865779
66TP53_22573176_ChIP-Seq_HFKS_Human1.24816342
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23433433
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22771709
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.21932298
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21932298
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.21834193
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.21425217
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.21233820
74RUNX2_22187159_ChIP-Seq_PCA_Human1.20725317
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.19749715
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19187899
77CDX2_22108803_ChIP-Seq_LS180_Human1.18020568
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17264018
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16845741
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16556137
81P53_22387025_ChIP-Seq_ESCs_Mouse1.15906754
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15804441
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14971492
84* GATA3_26560356_Chip-Seq_TH2_Human1.13945800
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.13056948
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11349626
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07128096
88AR_20517297_ChIP-Seq_VCAP_Human1.07048155
89* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06969862
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.05852161
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05171468
92P300_18555785_Chip-Seq_ESCs_Mouse1.04872332
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.03726533
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.03441331
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02800655
96NCOR_22424771_ChIP-Seq_293T_Human1.02418472
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00967973
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.00172750
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99954849
100RUNX_20019798_ChIP-Seq_JUKART_Human0.99877986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.36025419
2MP0003195_calcinosis3.31957934
3MP0000372_irregular_coat_pigmentation2.62718163
4MP0001986_abnormal_taste_sensitivity2.62114630
5MP0003646_muscle_fatigue2.55354088
6MP0008877_abnormal_DNA_methylation2.55095570
7MP0003787_abnormal_imprinting2.47476137
8MP0002102_abnormal_ear_morphology2.39804372
9MP0005551_abnormal_eye_electrophysiolog2.31797948
10MP0005075_abnormal_melanosome_morpholog2.31153020
11MP0003136_yellow_coat_color2.29421483
12MP0002876_abnormal_thyroid_physiology2.25671822
13MP0001501_abnormal_sleep_pattern2.01037855
14MP0005253_abnormal_eye_physiology1.85510384
15MP0008872_abnormal_physiological_respon1.84503941
16MP0001968_abnormal_touch/_nociception1.73769224
17MP0005671_abnormal_response_to1.71382843
18MP0001984_abnormal_olfaction1.65695846
19MP0003880_abnormal_central_pattern1.61249354
20MP0002837_dystrophic_cardiac_calcinosis1.60733974
21MP0002638_abnormal_pupillary_reflex1.60592390
22MP0003724_increased_susceptibility_to1.58308070
23MP0004043_abnormal_pH_regulation1.53606260
24MP0005174_abnormal_tail_pigmentation1.52858130
25MP0004142_abnormal_muscle_tone1.51155205
26MP0002009_preneoplasia1.50117469
27MP0000427_abnormal_hair_cycle1.49034773
28MP0002277_abnormal_respiratory_mucosa1.46883240
29MP0006072_abnormal_retinal_apoptosis1.42779787
30MP0002928_abnormal_bile_duct1.40806220
31MP0005645_abnormal_hypothalamus_physiol1.40418451
32MP0002938_white_spotting1.39342291
33MP0002736_abnormal_nociception_after1.36285042
34MP0005646_abnormal_pituitary_gland1.35646325
35MP0008995_early_reproductive_senescence1.34826654
36MP0009745_abnormal_behavioral_response1.31674214
37MP0001486_abnormal_startle_reflex1.31312277
38MP0008057_abnormal_DNA_replication1.31086718
39MP0006292_abnormal_olfactory_placode1.30037675
40MP0009046_muscle_twitch1.28270745
41MP0010386_abnormal_urinary_bladder1.24298748
42MP0004924_abnormal_behavior1.22728993
43MP0005386_behavior/neurological_phenoty1.22728993
44MP0002735_abnormal_chemical_nociception1.20133466
45MP0005171_absent_coat_pigmentation1.18826696
46MP0009764_decreased_sensitivity_to1.18270340
47MP0006276_abnormal_autonomic_nervous1.18187065
48MP0005084_abnormal_gallbladder_morpholo1.13624147
49MP0005410_abnormal_fertilization1.10781032
50MP0004381_abnormal_hair_follicle1.08684663
51MP0004147_increased_porphyrin_level1.08661702
52MP0002095_abnormal_skin_pigmentation1.07822290
53MP0002272_abnormal_nervous_system1.06151144
54MP0001764_abnormal_homeostasis1.05088765
55MP0002166_altered_tumor_susceptibility1.04708130
56MP0008875_abnormal_xenobiotic_pharmacok1.03938855
57MP0005310_abnormal_salivary_gland1.03484752
58MP0003252_abnormal_bile_duct1.03242107
59MP0008058_abnormal_DNA_repair1.03031907
60MP0000631_abnormal_neuroendocrine_gland1.01426265
61MP0002254_reproductive_system_inflammat1.01189711
62MP0001800_abnormal_humoral_immune0.98858884
63MP0003718_maternal_effect0.98359208
64MP0003121_genomic_imprinting0.94689661
65MP0000015_abnormal_ear_pigmentation0.94592891
66MP0004484_altered_response_of0.94457291
67MP0002067_abnormal_sensory_capabilities0.92936667
68MP0008961_abnormal_basal_metabolism0.92833787
69MP0002557_abnormal_social/conspecific_i0.87905555
70MP0005379_endocrine/exocrine_gland_phen0.87882367
71MP0009785_altered_susceptibility_to0.86674974
72MP0003698_abnormal_male_reproductive0.85585319
73MP0005167_abnormal_blood-brain_barrier0.85023518
74MP0004742_abnormal_vestibular_system0.84571597
75MP0008775_abnormal_heart_ventricle0.84448187
76MP0000230_abnormal_systemic_arterial0.84025476
77MP0000383_abnormal_hair_follicle0.83676071
78MP0001929_abnormal_gametogenesis0.83347787
79MP0002090_abnormal_vision0.82952006
80MP0002572_abnormal_emotion/affect_behav0.81991937
81MP0002229_neurodegeneration0.81302807
82MP0002653_abnormal_ependyma_morphology0.80601054
83MP0005647_abnormal_sex_gland0.80130479
84MP0004885_abnormal_endolymph0.79623166
85MP0001485_abnormal_pinna_reflex0.79602847
86MP0005266_abnormal_metabolism0.79431939
87MP0010329_abnormal_lipoprotein_level0.79026269
88MP0000371_diluted_coat_color0.78503054
89MP0005085_abnormal_gallbladder_physiolo0.77552774
90MP0005365_abnormal_bile_salt0.77023292
91MP0004215_abnormal_myocardial_fiber0.76794613
92MP0001324_abnormal_eye_pigmentation0.75086842
93MP0001970_abnormal_pain_threshold0.73457805
94MP0001873_stomach_inflammation0.71278114
95MP0003763_abnormal_thymus_physiology0.70475770
96MP0005389_reproductive_system_phenotype0.70001402
97MP0002006_tumorigenesis0.69662634
98MP0001905_abnormal_dopamine_level0.68836115
99MP0002723_abnormal_immune_serum0.68674109
100MP0001756_abnormal_urination0.68230237

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.17861122
2Pancreatic cysts (HP:0001737)4.13872786
3Hyperventilation (HP:0002883)3.79850414
4True hermaphroditism (HP:0010459)3.61358716
5Pancreatic fibrosis (HP:0100732)3.57266914
6Type II lissencephaly (HP:0007260)3.39152499
7Molar tooth sign on MRI (HP:0002419)3.30568842
8Abnormality of midbrain morphology (HP:0002418)3.30568842
9Medial flaring of the eyebrow (HP:0010747)3.25702863
10Stomach cancer (HP:0012126)3.24012410
11Nephronophthisis (HP:0000090)3.16649899
12Abnormality of the renal cortex (HP:0011035)3.11610053
13Gaze-evoked nystagmus (HP:0000640)3.04132779
14Attenuation of retinal blood vessels (HP:0007843)2.86603768
15Abnormality of the renal medulla (HP:0100957)2.86418957
16Decreased central vision (HP:0007663)2.71313396
17Chronic hepatic failure (HP:0100626)2.70462202
18Cerebellar dysplasia (HP:0007033)2.70381570
19Renal cortical cysts (HP:0000803)2.61051362
20Thyroiditis (HP:0100646)2.60960176
21Congenital primary aphakia (HP:0007707)2.54879443
22Gait imbalance (HP:0002141)2.53990430
23Abolished electroretinogram (ERG) (HP:0000550)2.49419811
24Stomatitis (HP:0010280)2.45558083
25Absent speech (HP:0001344)2.43894525
26Hypoplasia of the fovea (HP:0007750)2.39739858
27Aplasia/Hypoplasia of the fovea (HP:0008060)2.39739858
28Absent/shortened dynein arms (HP:0200106)2.39600506
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.39600506
30Febrile seizures (HP:0002373)2.34731493
31Nephrogenic diabetes insipidus (HP:0009806)2.33893800
32Hypothermia (HP:0002045)2.32933665
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.30655944
34Abnormal ciliary motility (HP:0012262)2.29800779
35Abnormal rod and cone electroretinograms (HP:0008323)2.27713755
36Large for gestational age (HP:0001520)2.26039489
37Lissencephaly (HP:0001339)2.25472731
38Genital tract atresia (HP:0001827)2.25175579
39Bile duct proliferation (HP:0001408)2.23400920
40Abnormal biliary tract physiology (HP:0012439)2.23400920
41Progressive cerebellar ataxia (HP:0002073)2.22422546
42Cystic liver disease (HP:0006706)2.21172353
43Intestinal atresia (HP:0011100)2.18298930
44Abnormality of the fovea (HP:0000493)2.12352450
45Tubular atrophy (HP:0000092)2.11520850
46Inability to walk (HP:0002540)2.11224723
47IgG deficiency (HP:0004315)2.10383389
48Vaginal atresia (HP:0000148)2.09729533
49Abnormality of macular pigmentation (HP:0008002)2.09464578
50Genetic anticipation (HP:0003743)2.08950266
51Abnormal drinking behavior (HP:0030082)2.06932116
52Polydipsia (HP:0001959)2.06932116
53Abnormal respiratory motile cilium physiology (HP:0012261)2.06208204
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01235001
55Abnormality of B cell number (HP:0010975)2.00634974
56Volvulus (HP:0002580)1.98662144
57Abnormal respiratory epithelium morphology (HP:0012253)1.97793049
58Abnormal respiratory motile cilium morphology (HP:0005938)1.97793049
59Hemiparesis (HP:0001269)1.96986290
60Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96702114
61Widely spaced teeth (HP:0000687)1.94103330
62Male pseudohermaphroditism (HP:0000037)1.93882014
63Hypoproteinemia (HP:0003075)1.93464261
64Progressive inability to walk (HP:0002505)1.92531517
65Pendular nystagmus (HP:0012043)1.92104583
66Constricted visual fields (HP:0001133)1.90867409
67Congenital sensorineural hearing impairment (HP:0008527)1.87054983
68Optic nerve hypoplasia (HP:0000609)1.85676237
69Severe combined immunodeficiency (HP:0004430)1.84435692
70Recurrent cutaneous fungal infections (HP:0011370)1.83326718
71Chronic mucocutaneous candidiasis (HP:0002728)1.83326718
72Poor coordination (HP:0002370)1.82691313
73Broad-based gait (HP:0002136)1.82460191
74Hypoplastic iliac wings (HP:0002866)1.82070101
75Pachygyria (HP:0001302)1.81117693
76Fair hair (HP:0002286)1.80304121
77Prostate neoplasm (HP:0100787)1.79616257
78Congenital hepatic fibrosis (HP:0002612)1.78470067
79Protruding tongue (HP:0010808)1.77116651
80Postaxial foot polydactyly (HP:0001830)1.77072177
81Abnormality of T cell number (HP:0011839)1.76943418
82Rhinitis (HP:0012384)1.75755946
83Increased corneal curvature (HP:0100692)1.75125582
84Keratoconus (HP:0000563)1.75125582
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.74745456
86Abnormality of eosinophils (HP:0001879)1.74482217
87Abnormality of the prostate (HP:0008775)1.73451631
88Albinism (HP:0001022)1.72356749
89Retinal dysplasia (HP:0007973)1.71992186
90Bony spicule pigmentary retinopathy (HP:0007737)1.71121434
91Sclerocornea (HP:0000647)1.70377555
92Polyuria (HP:0000103)1.69986696
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69838973
94Generalized hypopigmentation of hair (HP:0011358)1.68964173
95Methylmalonic acidemia (HP:0002912)1.68820004
96Aplasia/Hypoplasia of the macula (HP:0008059)1.68405597
97T lymphocytopenia (HP:0005403)1.67338238
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66135505
99Optic neuritis (HP:0100653)1.64688002
100Retrobulbar optic neuritis (HP:0100654)1.64688002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.17846183
2ACVR1B3.33859918
3TAOK32.97250498
4ZAK2.76024033
5NUAK12.63007690
6WNK32.56889800
7BMPR1B2.44339596
8ADRBK22.27309741
9TXK2.24046705
10TRIM282.05703024
11STK38L1.88783362
12MAPK131.80418714
13CASK1.79002223
14PINK11.76948941
15INSRR1.68867549
16GRK11.68050171
17MAP3K41.66707962
18MAP4K21.58702886
19ERBB31.47680729
20WNK41.33180577
21STK391.20471041
22OXSR11.20084747
23MST41.19873086
24TNK21.18302434
25PAK31.17233657
26LATS11.11535797
27PTK2B1.11346894
28TEC1.02507220
29EIF2AK31.00341985
30TLK10.98956988
31PNCK0.94229063
32DAPK20.94056296
33MARK30.91537708
34PIK3CG0.90985001
35TNIK0.90411182
36MARK10.88750548
37ADRBK10.86220617
38BRSK20.81395311
39MKNK20.80497743
40BRD40.78855971
41FGFR20.78674994
42CSNK1G20.77766507
43IKBKB0.76922745
44SIK30.76463289
45PRKCE0.75622093
46PLK20.72894678
47GRK60.72347317
48AKT30.72104376
49WEE10.71353126
50CAMKK20.70241658
51OBSCN0.69922251
52BCR0.69359837
53TGFBR10.68811473
54ITK0.68583577
55IKBKE0.64732259
56MAPK150.64519211
57CSNK1G10.63509479
58KIT0.62221946
59NLK0.61311773
60SYK0.60338300
61STK30.59885070
62CSNK1G30.59666189
63STK380.58515102
64PRKCQ0.58343389
65PIK3CA0.58223024
66DYRK30.57961123
67MAP3K70.57295554
68PDK20.56821228
69LYN0.56114144
70PRKAA20.55782314
71PRKCG0.55499410
72SGK20.55281758
73MUSK0.55158393
74CSNK1A1L0.54227761
75MAP3K140.52873324
76MAP2K70.51732454
77CHUK0.51578474
78NTRK30.51206526
79IRAK10.50853264
80VRK10.48827197
81PLK30.48686379
82FES0.45574089
83BTK0.44824486
84MAPKAPK50.44457340
85PKN10.43504311
86MAP4K10.42174471
87DYRK1A0.40919879
88BMPR20.40287964
89CSNK1D0.40110928
90PRKACA0.39284463
91EPHA30.39157404
92CAMK2A0.38916426
93PLK40.38536777
94PRKAA10.34997053
95MAP2K20.34542165
96SIK20.34359910
97LCK0.34226541
98TRPM70.33071534
99IRAK40.32816238
100WNK10.32513502

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.72619835
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54645957
3Butanoate metabolism_Homo sapiens_hsa006502.51001206
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47130228
5Linoleic acid metabolism_Homo sapiens_hsa005912.38145097
6Nitrogen metabolism_Homo sapiens_hsa009102.28372787
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26136578
8Caffeine metabolism_Homo sapiens_hsa002322.24287776
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10666505
10Protein export_Homo sapiens_hsa030602.00976287
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.95885079
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94316665
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.85115125
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84794158
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.79203297
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77257034
17Homologous recombination_Homo sapiens_hsa034401.72177408
18Primary immunodeficiency_Homo sapiens_hsa053401.70283537
19Ether lipid metabolism_Homo sapiens_hsa005651.68277153
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66369699
21Tryptophan metabolism_Homo sapiens_hsa003801.61566523
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60053708
23Propanoate metabolism_Homo sapiens_hsa006401.55504106
24Regulation of autophagy_Homo sapiens_hsa041401.54238768
25Basal transcription factors_Homo sapiens_hsa030221.54197023
26Circadian rhythm_Homo sapiens_hsa047101.53138882
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.51998022
28Fanconi anemia pathway_Homo sapiens_hsa034601.49615898
29Nicotine addiction_Homo sapiens_hsa050331.48003585
30Olfactory transduction_Homo sapiens_hsa047401.41096635
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38901410
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38825763
33Peroxisome_Homo sapiens_hsa041461.37590493
34Graft-versus-host disease_Homo sapiens_hsa053321.37589234
35ABC transporters_Homo sapiens_hsa020101.33765317
36Taste transduction_Homo sapiens_hsa047421.27065283
37Chemical carcinogenesis_Homo sapiens_hsa052041.26215397
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25215645
39Allograft rejection_Homo sapiens_hsa053301.24890731
40Asthma_Homo sapiens_hsa053101.21524835
41Type I diabetes mellitus_Homo sapiens_hsa049401.20220211
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18416044
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.17008817
44Autoimmune thyroid disease_Homo sapiens_hsa053201.16385351
45Arachidonic acid metabolism_Homo sapiens_hsa005901.16215856
46Retinol metabolism_Homo sapiens_hsa008301.02970677
47Morphine addiction_Homo sapiens_hsa050321.02390172
48Non-homologous end-joining_Homo sapiens_hsa034501.02055177
49RNA degradation_Homo sapiens_hsa030180.97398883
50Oxidative phosphorylation_Homo sapiens_hsa001900.97075114
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87591023
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85671658
53beta-Alanine metabolism_Homo sapiens_hsa004100.84830667
54Dorso-ventral axis formation_Homo sapiens_hsa043200.84792298
55Circadian entrainment_Homo sapiens_hsa047130.83062120
56Selenocompound metabolism_Homo sapiens_hsa004500.82288019
57Glycerolipid metabolism_Homo sapiens_hsa005610.82023019
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81681660
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80512785
60Fatty acid degradation_Homo sapiens_hsa000710.76163436
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72424093
62GABAergic synapse_Homo sapiens_hsa047270.71188559
63RNA polymerase_Homo sapiens_hsa030200.71085856
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69678279
65Serotonergic synapse_Homo sapiens_hsa047260.68956204
66Parkinsons disease_Homo sapiens_hsa050120.65739539
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61937121
68Calcium signaling pathway_Homo sapiens_hsa040200.61808288
69Salivary secretion_Homo sapiens_hsa049700.60965997
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58904702
71Insulin secretion_Homo sapiens_hsa049110.58436463
72Collecting duct acid secretion_Homo sapiens_hsa049660.58324776
73Ovarian steroidogenesis_Homo sapiens_hsa049130.57232158
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.56452422
75Glutamatergic synapse_Homo sapiens_hsa047240.55970236
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55885111
77Fat digestion and absorption_Homo sapiens_hsa049750.54351464
78Histidine metabolism_Homo sapiens_hsa003400.54291894
79Vitamin digestion and absorption_Homo sapiens_hsa049770.53968425
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53766776
81Huntingtons disease_Homo sapiens_hsa050160.53222156
82Sphingolipid metabolism_Homo sapiens_hsa006000.51730054
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51682435
84Rheumatoid arthritis_Homo sapiens_hsa053230.50207538
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.49808783
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48009041
87Lysine degradation_Homo sapiens_hsa003100.47065469
88Hematopoietic cell lineage_Homo sapiens_hsa046400.44874192
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44576596
90cAMP signaling pathway_Homo sapiens_hsa040240.39858080
91Antigen processing and presentation_Homo sapiens_hsa046120.38595046
92Amphetamine addiction_Homo sapiens_hsa050310.38208254
93Staphylococcus aureus infection_Homo sapiens_hsa051500.38025377
94Fatty acid metabolism_Homo sapiens_hsa012120.36104386
95Metabolic pathways_Homo sapiens_hsa011000.35902727
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.32314511
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30754920
98Dopaminergic synapse_Homo sapiens_hsa047280.30637509
99Renin secretion_Homo sapiens_hsa049240.30151470
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29973495

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