ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	4.43123947
2	establishment of protein localization to Golgi (GO:0072600)	4.07754338
3	detection of light stimulus involved in visual perception (GO:0050908)	3.72635493
4	detection of light stimulus involved in sensory perception (GO:0050962)	3.72635493
5	protein targeting to Golgi (GO:0000042)	3.63113489
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.57253254
7	L-fucose catabolic process (GO:0042355)	3.55275057
8	fucose catabolic process (GO:0019317)	3.55275057
9	L-fucose metabolic process (GO:0042354)	3.55275057
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.53770167
11	response to pheromone (GO:0019236)	3.46567884
12	indolalkylamine metabolic process (GO:0006586)	3.44093361
13	piRNA metabolic process (GO:0034587)	3.35935569
14	epithelial cilium movement (GO:0003351)	3.35101582
15	protein K11-linked deubiquitination (GO:0035871)	3.27184093
16	tryptophan catabolic process (GO:0006569)	3.23129898
17	indole-containing compound catabolic process (GO:0042436)	3.23129898
18	indolalkylamine catabolic process (GO:0046218)	3.23129898
19	cellular ketone body metabolic process (GO:0046950)	3.22990375
20	behavioral response to nicotine (GO:0035095)	3.22555326
21	protein localization to Golgi apparatus (GO:0034067)	3.22553815
22	ketone body metabolic process (GO:1902224)	3.20382510
23	preassembly of GPI anchor in ER membrane (GO:0016254)	3.18206706
24	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.15153511
25	protein polyglutamylation (GO:0018095)	3.04608680
26	cilium movement (GO:0003341)	3.04345927
27	cilium morphogenesis (GO:0060271)	3.02375926
28	cilium or flagellum-dependent cell motility (GO:0001539)	3.00945192
29	signal peptide processing (GO:0006465)	2.99759069
30	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.98047160
31	regulation of translation, ncRNA-mediated (GO:0045974)	2.98047160
32	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.98047160
33	axoneme assembly (GO:0035082)	2.97407353
34	platelet dense granule organization (GO:0060155)	2.96853471
35	protein localization to cilium (GO:0061512)	2.90425586
36	regulation of memory T cell differentiation (GO:0043380)	2.89156811
37	DNA deamination (GO:0045006)	2.87169231
38	tryptophan metabolic process (GO:0006568)	2.87075907
39	cilium organization (GO:0044782)	2.86088993
40	regulation of cilium movement (GO:0003352)	2.84033244
41	cornea development in camera-type eye (GO:0061303)	2.81263086
42	cilium assembly (GO:0042384)	2.78703275
43	regulation of meiosis I (GO:0060631)	2.76412779
44	mannosylation (GO:0097502)	2.73556004
45	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.72188637
46	intraciliary transport (GO:0042073)	2.70645205
47	monoubiquitinated protein deubiquitination (GO:0035520)	2.70598699
48	kynurenine metabolic process (GO:0070189)	2.68835190
49	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.66711825
50	multicellular organism reproduction (GO:0032504)	2.66092944
51	prenylation (GO:0097354)	2.65561800
52	protein prenylation (GO:0018342)	2.65561800
53	histone H3-K9 methylation (GO:0051567)	2.64987269
54	retinal cone cell development (GO:0046549)	2.64410213
55	tachykinin receptor signaling pathway (GO:0007217)	2.63453470
56	oxidative demethylation (GO:0070989)	2.63251241
57	presynaptic membrane assembly (GO:0097105)	2.62251863
58	centriole replication (GO:0007099)	2.61877457
59	negative regulation of mast cell activation (GO:0033004)	2.61714457
60	reflex (GO:0060004)	2.60601660
61	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.53823424
62	DNA methylation involved in gamete generation (GO:0043046)	2.53049948
63	embryonic epithelial tube formation (GO:0001838)	2.52642272
64	regulation of B cell receptor signaling pathway (GO:0050855)	2.51333755
65	histone H3-K4 trimethylation (GO:0080182)	2.50912549
66	behavioral response to ethanol (GO:0048149)	2.50745106
67	regulation of action potential (GO:0098900)	2.49193061
68	photoreceptor cell maintenance (GO:0045494)	2.49108224
69	sperm motility (GO:0030317)	2.47773900
70	indole-containing compound metabolic process (GO:0042430)	2.47735393
71	DNA demethylation (GO:0080111)	2.45808018
72	cell wall macromolecule metabolic process (GO:0044036)	2.45733204
73	cAMP catabolic process (GO:0006198)	2.43835849
74	rRNA catabolic process (GO:0016075)	2.42973416
75	positive regulation of developmental pigmentation (GO:0048087)	2.42270686
76	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.41566735
77	pyrimidine nucleobase catabolic process (GO:0006208)	2.38280885
78	regulation of sarcomere organization (GO:0060297)	2.37722487
79	gamma-aminobutyric acid transport (GO:0015812)	2.37544600
80	dopamine transport (GO:0015872)	2.37534193
81	intra-Golgi vesicle-mediated transport (GO:0006891)	2.37488312
82	recombinational repair (GO:0000725)	2.36719649
83	histone mRNA catabolic process (GO:0071044)	2.35851485
84	double-strand break repair via homologous recombination (GO:0000724)	2.35310157
85	protein K63-linked deubiquitination (GO:0070536)	2.34779885
86	limb bud formation (GO:0060174)	2.34453620
87	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.32657385
88	cell wall macromolecule catabolic process (GO:0016998)	2.32379791
89	respiratory chain complex IV assembly (GO:0008535)	2.31996893
90	interferon-gamma production (GO:0032609)	2.31882839
91	neuronal action potential (GO:0019228)	2.30828140
92	kidney morphogenesis (GO:0060993)	2.29456708
93	negative regulation of systemic arterial blood pressure (GO:0003085)	2.28652691
94	histone H3-K9 modification (GO:0061647)	2.27877247
95	photoreceptor cell development (GO:0042461)	2.26800421
96	cellular component assembly involved in morphogenesis (GO:0010927)	2.26503593
97	regulation of telomere maintenance (GO:0032204)	2.26256864
98	nonmotile primary cilium assembly (GO:0035058)	2.25909284
99	epithelial tube formation (GO:0072175)	2.25464898
100	seminiferous tubule development (GO:0072520)	2.25448690

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.44767993
2	VDR_22108803_ChIP-Seq_LS180_Human	3.05567026
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.93299022
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.85503098
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.73884770
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.62406987
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.38913367
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.34216005
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.33722782
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.30489505
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.24695480
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.16072139
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09330561
14	P300_19829295_ChIP-Seq_ESCs_Human	2.06402399
15	FUS_26573619_Chip-Seq_HEK293_Human	2.00564218
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94280683
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.92124848
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.90807927
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.88315594
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86941759
21	EWS_26573619_Chip-Seq_HEK293_Human	1.83574699
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.79819784
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.75964653
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.74634627
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.73831717
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.71524937
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68266280
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.66749955
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.66749955
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64991890
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64887032
32	STAT3_23295773_ChIP-Seq_U87_Human	1.64165457
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.59735159
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.58755824
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58589547
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55523621
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53489000
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50990746
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49670710
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49570131
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48909427
42	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.48554559
43	TCF4_23295773_ChIP-Seq_U87_Human	1.46054294
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.44947220
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44600829
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44600829
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43793890
48	AR_25329375_ChIP-Seq_VCAP_Human	1.37663000
49	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.36928204
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36458290
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35986292
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35197209
53	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.34758890
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33791849
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33791849
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.32659347
57	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.31560491
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31366519
59	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30803948
60	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30763732
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29183363
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28959242
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27564132
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.27107181
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25865779
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.24816342
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.23433433
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22771709
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21932298
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21932298
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21834193
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21425217
73	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.21233820
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20725317
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19749715
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19187899
77	CDX2_22108803_ChIP-Seq_LS180_Human	1.18020568
78	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17264018
79	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16845741
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16556137
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15906754
82	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.15804441
83	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.14971492
84	* GATA3_26560356_Chip-Seq_TH2_Human	1.13945800
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13056948
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11349626
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.07128096
88	AR_20517297_ChIP-Seq_VCAP_Human	1.07048155
89	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06969862
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05852161
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05171468
92	P300_18555785_Chip-Seq_ESCs_Mouse	1.04872332
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03726533
94	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.03441331
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02800655
96	NCOR_22424771_ChIP-Seq_293T_Human	1.02418472
97	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.00967973
98	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00172750
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99954849
100	RUNX_20019798_ChIP-Seq_JUKART_Human	0.99877986

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.36025419
2	MP0003195_calcinosis	3.31957934
3	MP0000372_irregular_coat_pigmentation	2.62718163
4	MP0001986_abnormal_taste_sensitivity	2.62114630
5	MP0003646_muscle_fatigue	2.55354088
6	MP0008877_abnormal_DNA_methylation	2.55095570
7	MP0003787_abnormal_imprinting	2.47476137
8	MP0002102_abnormal_ear_morphology	2.39804372
9	MP0005551_abnormal_eye_electrophysiolog	2.31797948
10	MP0005075_abnormal_melanosome_morpholog	2.31153020
11	MP0003136_yellow_coat_color	2.29421483
12	MP0002876_abnormal_thyroid_physiology	2.25671822
13	MP0001501_abnormal_sleep_pattern	2.01037855
14	MP0005253_abnormal_eye_physiology	1.85510384
15	MP0008872_abnormal_physiological_respon	1.84503941
16	MP0001968_abnormal_touch/_nociception	1.73769224
17	MP0005671_abnormal_response_to	1.71382843
18	MP0001984_abnormal_olfaction	1.65695846
19	MP0003880_abnormal_central_pattern	1.61249354
20	MP0002837_dystrophic_cardiac_calcinosis	1.60733974
21	MP0002638_abnormal_pupillary_reflex	1.60592390
22	MP0003724_increased_susceptibility_to	1.58308070
23	MP0004043_abnormal_pH_regulation	1.53606260
24	MP0005174_abnormal_tail_pigmentation	1.52858130
25	MP0004142_abnormal_muscle_tone	1.51155205
26	MP0002009_preneoplasia	1.50117469
27	MP0000427_abnormal_hair_cycle	1.49034773
28	MP0002277_abnormal_respiratory_mucosa	1.46883240
29	MP0006072_abnormal_retinal_apoptosis	1.42779787
30	MP0002928_abnormal_bile_duct	1.40806220
31	MP0005645_abnormal_hypothalamus_physiol	1.40418451
32	MP0002938_white_spotting	1.39342291
33	MP0002736_abnormal_nociception_after	1.36285042
34	MP0005646_abnormal_pituitary_gland	1.35646325
35	MP0008995_early_reproductive_senescence	1.34826654
36	MP0009745_abnormal_behavioral_response	1.31674214
37	MP0001486_abnormal_startle_reflex	1.31312277
38	MP0008057_abnormal_DNA_replication	1.31086718
39	MP0006292_abnormal_olfactory_placode	1.30037675
40	MP0009046_muscle_twitch	1.28270745
41	MP0010386_abnormal_urinary_bladder	1.24298748
42	MP0005386_behavior/neurological_phenoty	1.22728993
43	MP0004924_abnormal_behavior	1.22728993
44	MP0002735_abnormal_chemical_nociception	1.20133466
45	MP0005171_absent_coat_pigmentation	1.18826696
46	MP0009764_decreased_sensitivity_to	1.18270340
47	MP0006276_abnormal_autonomic_nervous	1.18187065
48	MP0005084_abnormal_gallbladder_morpholo	1.13624147
49	MP0005410_abnormal_fertilization	1.10781032
50	MP0004381_abnormal_hair_follicle	1.08684663
51	MP0004147_increased_porphyrin_level	1.08661702
52	MP0002095_abnormal_skin_pigmentation	1.07822290
53	MP0002272_abnormal_nervous_system	1.06151144
54	MP0001764_abnormal_homeostasis	1.05088765
55	MP0002166_altered_tumor_susceptibility	1.04708130
56	MP0008875_abnormal_xenobiotic_pharmacok	1.03938855
57	MP0005310_abnormal_salivary_gland	1.03484752
58	MP0003252_abnormal_bile_duct	1.03242107
59	MP0008058_abnormal_DNA_repair	1.03031907
60	MP0000631_abnormal_neuroendocrine_gland	1.01426265
61	MP0002254_reproductive_system_inflammat	1.01189711
62	MP0001800_abnormal_humoral_immune	0.98858884
63	MP0003718_maternal_effect	0.98359208
64	MP0003121_genomic_imprinting	0.94689661
65	MP0000015_abnormal_ear_pigmentation	0.94592891
66	MP0004484_altered_response_of	0.94457291
67	MP0002067_abnormal_sensory_capabilities	0.92936667
68	MP0008961_abnormal_basal_metabolism	0.92833787
69	MP0002557_abnormal_social/conspecific_i	0.87905555
70	MP0005379_endocrine/exocrine_gland_phen	0.87882367
71	MP0009785_altered_susceptibility_to	0.86674974
72	MP0003698_abnormal_male_reproductive	0.85585319
73	MP0005167_abnormal_blood-brain_barrier	0.85023518
74	MP0004742_abnormal_vestibular_system	0.84571597
75	MP0008775_abnormal_heart_ventricle	0.84448187
76	MP0000230_abnormal_systemic_arterial	0.84025476
77	MP0000383_abnormal_hair_follicle	0.83676071
78	MP0001929_abnormal_gametogenesis	0.83347787
79	MP0002090_abnormal_vision	0.82952006
80	MP0002572_abnormal_emotion/affect_behav	0.81991937
81	MP0002229_neurodegeneration	0.81302807
82	MP0002653_abnormal_ependyma_morphology	0.80601054
83	MP0005647_abnormal_sex_gland	0.80130479
84	MP0004885_abnormal_endolymph	0.79623166
85	MP0001485_abnormal_pinna_reflex	0.79602847
86	MP0005266_abnormal_metabolism	0.79431939
87	MP0010329_abnormal_lipoprotein_level	0.79026269
88	MP0000371_diluted_coat_color	0.78503054
89	MP0005085_abnormal_gallbladder_physiolo	0.77552774
90	MP0005365_abnormal_bile_salt	0.77023292
91	MP0004215_abnormal_myocardial_fiber	0.76794613
92	MP0001324_abnormal_eye_pigmentation	0.75086842
93	MP0001970_abnormal_pain_threshold	0.73457805
94	MP0001873_stomach_inflammation	0.71278114
95	MP0003763_abnormal_thymus_physiology	0.70475770
96	MP0005389_reproductive_system_phenotype	0.70001402
97	MP0002006_tumorigenesis	0.69662634
98	MP0001905_abnormal_dopamine_level	0.68836115
99	MP0002723_abnormal_immune_serum	0.68674109
100	MP0001756_abnormal_urination	0.68230237

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.17861122
2	Pancreatic cysts (HP:0001737)	4.13872786
3	Hyperventilation (HP:0002883)	3.79850414
4	True hermaphroditism (HP:0010459)	3.61358716
5	Pancreatic fibrosis (HP:0100732)	3.57266914
6	Type II lissencephaly (HP:0007260)	3.39152499
7	Abnormality of midbrain morphology (HP:0002418)	3.30568842
8	Molar tooth sign on MRI (HP:0002419)	3.30568842
9	Medial flaring of the eyebrow (HP:0010747)	3.25702863
10	Stomach cancer (HP:0012126)	3.24012410
11	Nephronophthisis (HP:0000090)	3.16649899
12	Abnormality of the renal cortex (HP:0011035)	3.11610053
13	Gaze-evoked nystagmus (HP:0000640)	3.04132779
14	Attenuation of retinal blood vessels (HP:0007843)	2.86603768
15	Abnormality of the renal medulla (HP:0100957)	2.86418957
16	Decreased central vision (HP:0007663)	2.71313396
17	Chronic hepatic failure (HP:0100626)	2.70462202
18	Cerebellar dysplasia (HP:0007033)	2.70381570
19	Renal cortical cysts (HP:0000803)	2.61051362
20	Thyroiditis (HP:0100646)	2.60960176
21	Congenital primary aphakia (HP:0007707)	2.54879443
22	Gait imbalance (HP:0002141)	2.53990430
23	Abolished electroretinogram (ERG) (HP:0000550)	2.49419811
24	Stomatitis (HP:0010280)	2.45558083
25	Absent speech (HP:0001344)	2.43894525
26	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.39739858
27	Hypoplasia of the fovea (HP:0007750)	2.39739858
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39600506
29	Absent/shortened dynein arms (HP:0200106)	2.39600506
30	Febrile seizures (HP:0002373)	2.34731493
31	Nephrogenic diabetes insipidus (HP:0009806)	2.33893800
32	Hypothermia (HP:0002045)	2.32933665
33	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.30655944
34	Abnormal ciliary motility (HP:0012262)	2.29800779
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.27713755
36	Large for gestational age (HP:0001520)	2.26039489
37	Lissencephaly (HP:0001339)	2.25472731
38	Genital tract atresia (HP:0001827)	2.25175579
39	Abnormal biliary tract physiology (HP:0012439)	2.23400920
40	Bile duct proliferation (HP:0001408)	2.23400920
41	Progressive cerebellar ataxia (HP:0002073)	2.22422546
42	Cystic liver disease (HP:0006706)	2.21172353
43	Intestinal atresia (HP:0011100)	2.18298930
44	Abnormality of the fovea (HP:0000493)	2.12352450
45	Tubular atrophy (HP:0000092)	2.11520850
46	Inability to walk (HP:0002540)	2.11224723
47	IgG deficiency (HP:0004315)	2.10383389
48	Vaginal atresia (HP:0000148)	2.09729533
49	Abnormality of macular pigmentation (HP:0008002)	2.09464578
50	Genetic anticipation (HP:0003743)	2.08950266
51	Polydipsia (HP:0001959)	2.06932116
52	Abnormal drinking behavior (HP:0030082)	2.06932116
53	Abnormal respiratory motile cilium physiology (HP:0012261)	2.06208204
54	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.01235001
55	Abnormality of B cell number (HP:0010975)	2.00634974
56	Volvulus (HP:0002580)	1.98662144
57	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97793049
58	Abnormal respiratory epithelium morphology (HP:0012253)	1.97793049
59	Hemiparesis (HP:0001269)	1.96986290
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.96702114
61	Widely spaced teeth (HP:0000687)	1.94103330
62	Male pseudohermaphroditism (HP:0000037)	1.93882014
63	Hypoproteinemia (HP:0003075)	1.93464261
64	Progressive inability to walk (HP:0002505)	1.92531517
65	Pendular nystagmus (HP:0012043)	1.92104583
66	Constricted visual fields (HP:0001133)	1.90867409
67	Congenital sensorineural hearing impairment (HP:0008527)	1.87054983
68	Optic nerve hypoplasia (HP:0000609)	1.85676237
69	Severe combined immunodeficiency (HP:0004430)	1.84435692
70	Chronic mucocutaneous candidiasis (HP:0002728)	1.83326718
71	Recurrent cutaneous fungal infections (HP:0011370)	1.83326718
72	Poor coordination (HP:0002370)	1.82691313
73	Broad-based gait (HP:0002136)	1.82460191
74	Hypoplastic iliac wings (HP:0002866)	1.82070101
75	Pachygyria (HP:0001302)	1.81117693
76	Fair hair (HP:0002286)	1.80304121
77	Prostate neoplasm (HP:0100787)	1.79616257
78	Congenital hepatic fibrosis (HP:0002612)	1.78470067
79	Protruding tongue (HP:0010808)	1.77116651
80	Postaxial foot polydactyly (HP:0001830)	1.77072177
81	Abnormality of T cell number (HP:0011839)	1.76943418
82	Rhinitis (HP:0012384)	1.75755946
83	Keratoconus (HP:0000563)	1.75125582
84	Increased corneal curvature (HP:0100692)	1.75125582
85	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74745456
86	Abnormality of eosinophils (HP:0001879)	1.74482217
87	Abnormality of the prostate (HP:0008775)	1.73451631
88	Albinism (HP:0001022)	1.72356749
89	Retinal dysplasia (HP:0007973)	1.71992186
90	Bony spicule pigmentary retinopathy (HP:0007737)	1.71121434
91	Sclerocornea (HP:0000647)	1.70377555
92	Polyuria (HP:0000103)	1.69986696
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69838973
94	Generalized hypopigmentation of hair (HP:0011358)	1.68964173
95	Methylmalonic acidemia (HP:0002912)	1.68820004
96	Aplasia/Hypoplasia of the macula (HP:0008059)	1.68405597
97	T lymphocytopenia (HP:0005403)	1.67338238
98	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.66135505
99	Retrobulbar optic neuritis (HP:0100654)	1.64688002
100	Optic neuritis (HP:0100653)	1.64688002

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.17846183
2	ACVR1B	3.33859918
3	TAOK3	2.97250498
4	ZAK	2.76024033
5	NUAK1	2.63007690
6	WNK3	2.56889800
7	BMPR1B	2.44339596
8	ADRBK2	2.27309741
9	TXK	2.24046705
10	TRIM28	2.05703024
11	STK38L	1.88783362
12	MAPK13	1.80418714
13	CASK	1.79002223
14	PINK1	1.76948941
15	INSRR	1.68867549
16	GRK1	1.68050171
17	MAP3K4	1.66707962
18	MAP4K2	1.58702886
19	ERBB3	1.47680729
20	WNK4	1.33180577
21	STK39	1.20471041
22	OXSR1	1.20084747
23	MST4	1.19873086
24	TNK2	1.18302434
25	PAK3	1.17233657
26	LATS1	1.11535797
27	PTK2B	1.11346894
28	TEC	1.02507220
29	EIF2AK3	1.00341985
30	TLK1	0.98956988
31	PNCK	0.94229063
32	DAPK2	0.94056296
33	MARK3	0.91537708
34	PIK3CG	0.90985001
35	TNIK	0.90411182
36	MARK1	0.88750548
37	ADRBK1	0.86220617
38	BRSK2	0.81395311
39	MKNK2	0.80497743
40	BRD4	0.78855971
41	FGFR2	0.78674994
42	CSNK1G2	0.77766507
43	IKBKB	0.76922745
44	SIK3	0.76463289
45	PRKCE	0.75622093
46	PLK2	0.72894678
47	GRK6	0.72347317
48	AKT3	0.72104376
49	WEE1	0.71353126
50	CAMKK2	0.70241658
51	OBSCN	0.69922251
52	BCR	0.69359837
53	TGFBR1	0.68811473
54	ITK	0.68583577
55	IKBKE	0.64732259
56	MAPK15	0.64519211
57	CSNK1G1	0.63509479
58	KIT	0.62221946
59	NLK	0.61311773
60	SYK	0.60338300
61	STK3	0.59885070
62	CSNK1G3	0.59666189
63	STK38	0.58515102
64	PRKCQ	0.58343389
65	PIK3CA	0.58223024
66	DYRK3	0.57961123
67	MAP3K7	0.57295554
68	PDK2	0.56821228
69	LYN	0.56114144
70	PRKAA2	0.55782314
71	PRKCG	0.55499410
72	SGK2	0.55281758
73	MUSK	0.55158393
74	CSNK1A1L	0.54227761
75	MAP3K14	0.52873324
76	MAP2K7	0.51732454
77	CHUK	0.51578474
78	NTRK3	0.51206526
79	IRAK1	0.50853264
80	VRK1	0.48827197
81	PLK3	0.48686379
82	FES	0.45574089
83	BTK	0.44824486
84	MAPKAPK5	0.44457340
85	PKN1	0.43504311
86	MAP4K1	0.42174471
87	DYRK1A	0.40919879
88	BMPR2	0.40287964
89	CSNK1D	0.40110928
90	PRKACA	0.39284463
91	EPHA3	0.39157404
92	CAMK2A	0.38916426
93	PLK4	0.38536777
94	PRKAA1	0.34997053
95	MAP2K2	0.34542165
96	SIK2	0.34359910
97	LCK	0.34226541
98	TRPM7	0.33071534
99	IRAK4	0.32816238
100	WNK1	0.32513502

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.72619835
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.54645957
3	Butanoate metabolism_Homo sapiens_hsa00650	2.51001206
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.47130228
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38145097
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.28372787
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26136578
8	Caffeine metabolism_Homo sapiens_hsa00232	2.24287776
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.10666505
10	Protein export_Homo sapiens_hsa03060	2.00976287
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.95885079
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.94316665
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.85115125
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.84794158
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.79203297
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77257034
17	Homologous recombination_Homo sapiens_hsa03440	1.72177408
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.70283537
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.68277153
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.66369699
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.61566523
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60053708
23	Propanoate metabolism_Homo sapiens_hsa00640	1.55504106
24	Regulation of autophagy_Homo sapiens_hsa04140	1.54238768
25	Basal transcription factors_Homo sapiens_hsa03022	1.54197023
26	Circadian rhythm_Homo sapiens_hsa04710	1.53138882
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.51998022
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49615898
29	Nicotine addiction_Homo sapiens_hsa05033	1.48003585
30	Olfactory transduction_Homo sapiens_hsa04740	1.41096635
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.38901410
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.38825763
33	Peroxisome_Homo sapiens_hsa04146	1.37590493
34	Graft-versus-host disease_Homo sapiens_hsa05332	1.37589234
35	ABC transporters_Homo sapiens_hsa02010	1.33765317
36	Taste transduction_Homo sapiens_hsa04742	1.27065283
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26215397
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25215645
39	Allograft rejection_Homo sapiens_hsa05330	1.24890731
40	Asthma_Homo sapiens_hsa05310	1.21524835
41	Type I diabetes mellitus_Homo sapiens_hsa04940	1.20220211
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18416044
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.17008817
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.16385351
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.16215856
46	Retinol metabolism_Homo sapiens_hsa00830	1.02970677
47	Morphine addiction_Homo sapiens_hsa05032	1.02390172
48	Non-homologous end-joining_Homo sapiens_hsa03450	1.02055177
49	RNA degradation_Homo sapiens_hsa03018	0.97398883
50	Oxidative phosphorylation_Homo sapiens_hsa00190	0.97075114
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87591023
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85671658
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84830667
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.84792298
55	Circadian entrainment_Homo sapiens_hsa04713	0.83062120
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.82288019
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82023019
58	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.81681660
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80512785
60	Fatty acid degradation_Homo sapiens_hsa00071	0.76163436
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72424093
62	GABAergic synapse_Homo sapiens_hsa04727	0.71188559
63	RNA polymerase_Homo sapiens_hsa03020	0.71085856
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69678279
65	Serotonergic synapse_Homo sapiens_hsa04726	0.68956204
66	Parkinsons disease_Homo sapiens_hsa05012	0.65739539
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61937121
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.61808288
69	Salivary secretion_Homo sapiens_hsa04970	0.60965997
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58904702
71	Insulin secretion_Homo sapiens_hsa04911	0.58436463
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58324776
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57232158
74	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.56452422
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.55970236
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55885111
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.54351464
78	Histidine metabolism_Homo sapiens_hsa00340	0.54291894
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53968425
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53766776
81	Huntingtons disease_Homo sapiens_hsa05016	0.53222156
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.51730054
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.51682435
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50207538
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49808783
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.48009041
87	Lysine degradation_Homo sapiens_hsa00310	0.47065469
88	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.44874192
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44576596
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.39858080
91	Antigen processing and presentation_Homo sapiens_hsa04612	0.38595046
92	Amphetamine addiction_Homo sapiens_hsa05031	0.38208254
93	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.38025377
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.36104386
95	Metabolic pathways_Homo sapiens_hsa01100	0.35902727
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32314511
97	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30754920
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.30637509
99	Renin secretion_Homo sapiens_hsa04924	0.30151470
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.29973495

ZNF44

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »