ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	9.79839896
2	cilium movement (GO:0003341)	9.67398016
3	epithelial cilium movement (GO:0003351)	8.68504117
4	motile cilium assembly (GO:0044458)	7.64674450
5	axoneme assembly (GO:0035082)	7.46175197
6	regulation of cilium movement (GO:0003352)	6.84085215
7	pyrimidine nucleobase catabolic process (GO:0006208)	5.45975565
8	cilium organization (GO:0044782)	5.03145977
9	left/right axis specification (GO:0070986)	4.85957258
10	cilium assembly (GO:0042384)	4.84314219
11	left/right pattern formation (GO:0060972)	4.72022797
12	intraciliary transport (GO:0042073)	4.63265563
13	nucleobase catabolic process (GO:0046113)	4.52169064
14	cilium morphogenesis (GO:0060271)	4.38322491
15	microtubule bundle formation (GO:0001578)	4.30438938
16	protein localization to cilium (GO:0061512)	4.17521151
17	regulation of microtubule-based movement (GO:0060632)	4.04329546
18	ventricular system development (GO:0021591)	4.00983221
19	behavioral response to nicotine (GO:0035095)	3.95417824
20	cellular component assembly involved in morphogenesis (GO:0010927)	3.95103990
21	centriole replication (GO:0007099)	3.89129685
22	nonmotile primary cilium assembly (GO:0035058)	3.84723577
23	rRNA catabolic process (GO:0016075)	3.82802445
24	centriole assembly (GO:0098534)	3.72945027
25	neural tube formation (GO:0001841)	3.67800572
26	vitamin transmembrane transport (GO:0035461)	3.67788797
27	L-fucose catabolic process (GO:0042355)	3.54248308
28	fucose catabolic process (GO:0019317)	3.54248308
29	L-fucose metabolic process (GO:0042354)	3.54248308
30	photoreceptor cell maintenance (GO:0045494)	3.50107263
31	sperm motility (GO:0030317)	3.42664751
32	response to pheromone (GO:0019236)	3.32970302
33	microtubule depolymerization (GO:0007019)	3.30967515
34	protein polyglutamylation (GO:0018095)	3.26831465
35	cell projection assembly (GO:0030031)	3.25368465
36	retinal cone cell development (GO:0046549)	3.23427903
37	negative regulation of T cell differentiation in thymus (GO:0033085)	3.12515906
38	multicellular organism reproduction (GO:0032504)	3.08593555
39	smoothened signaling pathway (GO:0007224)	3.07470834
40	exogenous drug catabolic process (GO:0042738)	3.05450901
41	response to xenobiotic stimulus (GO:0009410)	3.05263159
42	microtubule-based movement (GO:0007018)	3.02717464
43	determination of left/right symmetry (GO:0007368)	3.01845259
44	microtubule polymerization or depolymerization (GO:0031109)	2.98773736
45	brain morphogenesis (GO:0048854)	2.93676321
46	drug catabolic process (GO:0042737)	2.92957110
47	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.92675569
48	indolalkylamine metabolic process (GO:0006586)	2.85510273
49	determination of bilateral symmetry (GO:0009855)	2.84943537
50	retinal rod cell development (GO:0046548)	2.82183652
51	regulation of collateral sprouting (GO:0048670)	2.81440031
52	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.80382947
53	lateral ventricle development (GO:0021670)	2.78981891
54	diterpenoid biosynthetic process (GO:0016102)	2.78116528
55	specification of symmetry (GO:0009799)	2.77235350
56	cornea development in camera-type eye (GO:0061303)	2.75473690
57	establishment of protein localization to Golgi (GO:0072600)	2.70549094
58	retinoic acid metabolic process (GO:0042573)	2.69427630
59	photoreceptor cell development (GO:0042461)	2.68181831
60	primary alcohol catabolic process (GO:0034310)	2.67111654
61	cellular ketone body metabolic process (GO:0046950)	2.65730988
62	one-carbon compound transport (GO:0019755)	2.64874763
63	regulation of feeding behavior (GO:0060259)	2.64175615
64	spinal cord motor neuron differentiation (GO:0021522)	2.61360464
65	kidney morphogenesis (GO:0060993)	2.61033232
66	behavioral response to ethanol (GO:0048149)	2.57821154
67	regulation of glucokinase activity (GO:0033131)	2.57419639
68	regulation of hexokinase activity (GO:1903299)	2.57419639
69	detection of light stimulus involved in visual perception (GO:0050908)	2.53752422
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.53752422
71	tachykinin receptor signaling pathway (GO:0007217)	2.52757774
72	magnesium ion transport (GO:0015693)	2.49428722
73	sperm capacitation (GO:0048240)	2.48734786
74	ketone body metabolic process (GO:1902224)	2.47568311
75	eye photoreceptor cell development (GO:0042462)	2.46277746
76	kynurenine metabolic process (GO:0070189)	2.44248769
77	atrial cardiac muscle cell action potential (GO:0086014)	2.41980996
78	regulation of action potential (GO:0098900)	2.41785401
79	indole-containing compound catabolic process (GO:0042436)	2.41701723
80	indolalkylamine catabolic process (GO:0046218)	2.41701723
81	tryptophan catabolic process (GO:0006569)	2.41701723
82	sialylation (GO:0097503)	2.41357860
83	benzene-containing compound metabolic process (GO:0042537)	2.40299914
84	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.40159033
85	ethanol metabolic process (GO:0006067)	2.38286289
86	negative regulation of mast cell activation (GO:0033004)	2.38142106
87	regulation of hippo signaling (GO:0035330)	2.37721062
88	thyroid hormone metabolic process (GO:0042403)	2.34864091
89	limb development (GO:0060173)	2.33321037
90	appendage development (GO:0048736)	2.33321037
91	organelle assembly (GO:0070925)	2.33132060
92	ncRNA catabolic process (GO:0034661)	2.32954522
93	nucleoside diphosphate phosphorylation (GO:0006165)	2.30601781
94	oxidative demethylation (GO:0070989)	2.28792361
95	sympathetic nervous system development (GO:0048485)	2.28664105
96	intra-S DNA damage checkpoint (GO:0031573)	2.26429381
97	transmission of nerve impulse (GO:0019226)	2.25895157
98	regulation of germinal center formation (GO:0002634)	2.25720509
99	cilium or flagellum-dependent cell motility (GO:0001539)	11.2026384
100	axonemal dynein complex assembly (GO:0070286)	11.1459565

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92593931
2	VDR_22108803_ChIP-Seq_LS180_Human	3.53677251
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.79320642
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57428305
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.55466308
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.35188048
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.34196348
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33531808
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.31454423
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.30651333
11	FUS_26573619_Chip-Seq_HEK293_Human	2.29379756
12	EWS_26573619_Chip-Seq_HEK293_Human	2.28120698
13	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.19115013
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17358169
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09425541
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.09401741
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.03659042
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.99104950
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.99048002
20	P300_19829295_ChIP-Seq_ESCs_Human	1.97820302
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.92341098
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.89055884
23	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.82122923
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.76048195
25	STAT3_23295773_ChIP-Seq_U87_Human	1.75508962
26	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.75131250
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72005224
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70523019
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69591095
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.69589030
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69342265
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63679763
33	DROSHA_22980978_ChIP-Seq_HELA_Human	1.58762047
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.58578749
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.57588909
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57588909
37	* TCF4_23295773_ChIP-Seq_U87_Human	1.56517146
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55823306
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55225581
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55174322
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49349904
42	* TCF4_22108803_ChIP-Seq_LS180_Human	1.44420844
43	AR_25329375_ChIP-Seq_VCAP_Human	1.43772856
44	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.43075668
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.41504585
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40128333
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40128333
48	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.39727361
49	TP53_16413492_ChIP-PET_HCT116_Human	1.38264014
50	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.38171484
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36707140
52	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30734099
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.29565536
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26832377
55	AR_21572438_ChIP-Seq_LNCaP_Human	1.26636533
56	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26052886
57	AHR_22903824_ChIP-Seq_MCF-7_Human	1.25332110
58	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25140588
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24078524
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.23339145
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22979025
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20726194
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20047394
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20047394
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18259354
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18259354
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16985354
68	TP53_18474530_ChIP-ChIP_U2OS_Human	1.16434745
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15483335
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15189606
71	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13939376
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13378636
73	NCOR_22424771_ChIP-Seq_293T_Human	1.12678314
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11917602
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10912821
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.10278165
77	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10220293
78	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09770733
79	TBL1_22424771_ChIP-Seq_293T_Human	1.09112108
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08724790
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08717366
82	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.08181355
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05290773
84	AR_20517297_ChIP-Seq_VCAP_Human	1.04990098
85	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.04600335
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02472691
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02299146
88	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02190453
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01475558
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01351377
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01137027
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00431311
93	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00187946
94	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00127802
95	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.99899694
96	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.99160465
97	SMRT_27268052_Chip-Seq_Bcells_Human	0.98566702
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.98124248
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96587520
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96336748

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	3.75111599
2	MP0002653_abnormal_ependyma_morphology	3.66516203
3	MP0004043_abnormal_pH_regulation	3.22778486
4	MP0001984_abnormal_olfaction	2.82774371
5	MP0004133_heterotaxia	2.43111472
6	MP0003136_yellow_coat_color	2.40266936
7	MP0003195_calcinosis	2.34651599
8	MP0008872_abnormal_physiological_respon	2.22441143
9	MP0005551_abnormal_eye_electrophysiolog	2.19978324
10	MP0000383_abnormal_hair_follicle	2.19895918
11	MP0001485_abnormal_pinna_reflex	2.09973929
12	MP0002876_abnormal_thyroid_physiology	1.99899597
13	MP0002102_abnormal_ear_morphology	1.93460566
14	MP0002277_abnormal_respiratory_mucosa	1.91151764
15	MP0002638_abnormal_pupillary_reflex	1.91110566
16	MP0000427_abnormal_hair_cycle	1.87894625
17	MP0008789_abnormal_olfactory_epithelium	1.78988811
18	MP0003890_abnormal_embryonic-extraembry	1.78133500
19	MP0005253_abnormal_eye_physiology	1.70797320
20	MP0000516_abnormal_urinary_system	1.63146466
21	MP0005367_renal/urinary_system_phenotyp	1.63146466
22	MP0001529_abnormal_vocalization	1.61047980
23	MP0000372_irregular_coat_pigmentation	1.60802198
24	MP0002160_abnormal_reproductive_system	1.56626568
25	MP0002132_abnormal_respiratory_system	1.53614649
26	MP0001986_abnormal_taste_sensitivity	1.48685631
27	MP0002928_abnormal_bile_duct	1.47104895
28	MP0000569_abnormal_digit_pigmentation	1.45882748
29	MP0008877_abnormal_DNA_methylation	1.45258794
30	MP0003718_maternal_effect	1.40496774
31	MP0002735_abnormal_chemical_nociception	1.40479084
32	MP0010678_abnormal_skin_adnexa	1.38900558
33	MP0001486_abnormal_startle_reflex	1.36560626
34	MP0003252_abnormal_bile_duct	1.33496166
35	MP0006072_abnormal_retinal_apoptosis	1.32409956
36	MP0000566_synostosis	1.32054355
37	MP0001968_abnormal_touch/_nociception	1.31668305
38	MP0003878_abnormal_ear_physiology	1.29768345
39	MP0005377_hearing/vestibular/ear_phenot	1.29768345
40	MP0003787_abnormal_imprinting	1.28676139
41	MP0003698_abnormal_male_reproductive	1.24832978
42	MP0006292_abnormal_olfactory_placode	1.24285283
43	MP0005389_reproductive_system_phenotype	1.23049789
44	MP0004142_abnormal_muscle_tone	1.22040072
45	MP0004019_abnormal_vitamin_homeostasis	1.20804718
46	MP0005646_abnormal_pituitary_gland	1.19831763
47	MP0001929_abnormal_gametogenesis	1.19432898
48	MP0004885_abnormal_endolymph	1.18367567
49	MP0005499_abnormal_olfactory_system	1.18016172
50	MP0005394_taste/olfaction_phenotype	1.18016172
51	MP0001970_abnormal_pain_threshold	1.17390250
52	MP0005085_abnormal_gallbladder_physiolo	1.17319403
53	MP0009046_muscle_twitch	1.16432421
54	MP0002282_abnormal_trachea_morphology	1.12994558
55	MP0002938_white_spotting	1.12315387
56	MP0003656_abnormal_erythrocyte_physiolo	1.11915590
57	MP0000631_abnormal_neuroendocrine_gland	1.11088766
58	MP0005310_abnormal_salivary_gland	1.10243553
59	MP0001324_abnormal_eye_pigmentation	1.08446415
60	MP0004924_abnormal_behavior	1.06769286
61	MP0005386_behavior/neurological_phenoty	1.06769286
62	MP0005174_abnormal_tail_pigmentation	1.06116039
63	MP0005645_abnormal_hypothalamus_physiol	1.06038842
64	MP0005395_other_phenotype	1.05947971
65	MP0005083_abnormal_biliary_tract	1.05446829
66	MP0003011_delayed_dark_adaptation	1.04829147
67	MP0009745_abnormal_behavioral_response	1.03626804
68	MP0005195_abnormal_posterior_eye	1.02074698
69	MP0002168_other_aberrant_phenotype	1.01818758
70	MP0002736_abnormal_nociception_after	1.01703502
71	MP0006276_abnormal_autonomic_nervous	1.00927881
72	MP0001346_abnormal_lacrimal_gland	0.99857143
73	MP0003937_abnormal_limbs/digits/tail_de	0.98984555
74	MP0000647_abnormal_sebaceous_gland	0.97326532
75	MP0001765_abnormal_ion_homeostasis	0.96649381
76	MP0006054_spinal_hemorrhage	0.96224765
77	MP0003880_abnormal_central_pattern	0.95188975
78	MP0002734_abnormal_mechanical_nocicepti	0.94899011
79	MP0002733_abnormal_thermal_nociception	0.92526080
80	MP0008995_early_reproductive_senescence	0.91198694
81	MP0002751_abnormal_autonomic_nervous	0.90206623
82	MP0005084_abnormal_gallbladder_morpholo	0.89795856
83	MP0002272_abnormal_nervous_system	0.89353761
84	MP0000778_abnormal_nervous_system	0.88757429
85	MP0002557_abnormal_social/conspecific_i	0.88238467
86	MP0002572_abnormal_emotion/affect_behav	0.88158740
87	MP0005636_abnormal_mineral_homeostasis	0.87133679
88	MP0005410_abnormal_fertilization	0.86445992
89	MP0003119_abnormal_digestive_system	0.86113589
90	MP0004147_increased_porphyrin_level	0.85150090
91	MP0002067_abnormal_sensory_capabilities	0.84816797
92	MP0001293_anophthalmia	0.83341428
93	MP0002095_abnormal_skin_pigmentation	0.82268623
94	MP0000026_abnormal_inner_ear	0.82070060
95	MP0002752_abnormal_somatic_nervous	0.81392383
96	MP0010386_abnormal_urinary_bladder	0.81150162
97	MP0005365_abnormal_bile_salt	0.80957149
98	MP0003943_abnormal_hepatobiliary_system	0.79959995
99	MP0005075_abnormal_melanosome_morpholog	0.79129117
100	MP0003950_abnormal_plasma_membrane	0.79057072

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.94401260
2	Absent/shortened dynein arms (HP:0200106)	7.94401260
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	7.85902697
4	Abnormal respiratory motile cilium morphology (HP:0005938)	7.77847694
5	Abnormal respiratory epithelium morphology (HP:0012253)	7.77847694
6	Abnormal ciliary motility (HP:0012262)	7.56940829
7	Abnormal respiratory motile cilium physiology (HP:0012261)	7.33486110
8	Rhinitis (HP:0012384)	6.75487130
9	Bronchiectasis (HP:0002110)	5.02896908
10	Chronic bronchitis (HP:0004469)	4.81236383
11	Pancreatic fibrosis (HP:0100732)	4.67306558
12	Pancreatic cysts (HP:0001737)	4.60283500
13	True hermaphroditism (HP:0010459)	4.40275316
14	Abnormality of midbrain morphology (HP:0002418)	4.35226920
15	Molar tooth sign on MRI (HP:0002419)	4.35226920
16	Nephronophthisis (HP:0000090)	4.02632113
17	Chronic hepatic failure (HP:0100626)	3.87948058
18	Nasal polyposis (HP:0100582)	3.72849043
19	Abnormality of the renal medulla (HP:0100957)	3.44275557
20	Cystic liver disease (HP:0006706)	3.43924233
21	Medial flaring of the eyebrow (HP:0010747)	3.19172841
22	Chronic sinusitis (HP:0011109)	3.07742593
23	Tubulointerstitial nephritis (HP:0001970)	2.95908067
24	Bronchitis (HP:0012387)	2.89167794
25	Tubular atrophy (HP:0000092)	2.84598049
26	Abnormality of the nasal mucosa (HP:0000433)	2.83583814
27	Abnormality of the renal cortex (HP:0011035)	2.80467380
28	Postaxial foot polydactyly (HP:0001830)	2.80385828
29	Occipital encephalocele (HP:0002085)	2.78861420
30	Congenital hepatic fibrosis (HP:0002612)	2.76089478
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.69672292
32	Recurrent sinusitis (HP:0011108)	2.69279032
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.64247262
34	Gait imbalance (HP:0002141)	2.58962445
35	Congenital primary aphakia (HP:0007707)	2.58250383
36	Chronic otitis media (HP:0000389)	2.57552870
37	Infertility (HP:0000789)	2.52795923
38	Polydipsia (HP:0001959)	2.51168834
39	Abnormal drinking behavior (HP:0030082)	2.51168834
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.45454612
41	Decreased circulating renin level (HP:0003351)	2.44123246
42	Anencephaly (HP:0002323)	2.43253526
43	Sclerocornea (HP:0000647)	2.36252914
44	Asplenia (HP:0001746)	2.35398074
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.34601480
46	Nephrogenic diabetes insipidus (HP:0009806)	2.34039424
47	Hyperventilation (HP:0002883)	2.30120170
48	Furrowed tongue (HP:0000221)	2.30090274
49	Genital tract atresia (HP:0001827)	2.26985824
50	Postaxial hand polydactyly (HP:0001162)	2.20607803
51	Male pseudohermaphroditism (HP:0000037)	2.19717300
52	Type II lissencephaly (HP:0007260)	2.17807692
53	Congenital stationary night blindness (HP:0007642)	2.15110784
54	Hyperactive renin-angiotensin system (HP:0000841)	2.13869180
55	Vaginal atresia (HP:0000148)	2.12821298
56	Abolished electroretinogram (ERG) (HP:0000550)	2.01313694
57	Recurrent otitis media (HP:0000403)	2.00860186
58	Gaze-evoked nystagmus (HP:0000640)	2.00618447
59	Decreased central vision (HP:0007663)	1.99248436
60	Tubulointerstitial abnormality (HP:0001969)	1.96334163
61	Broad-based gait (HP:0002136)	1.95859206
62	Preaxial hand polydactyly (HP:0001177)	1.94077535
63	Genetic anticipation (HP:0003743)	1.92831340
64	Poor coordination (HP:0002370)	1.92240886
65	Polyuria (HP:0000103)	1.86595522
66	Attenuation of retinal blood vessels (HP:0007843)	1.85199447
67	Male infertility (HP:0003251)	1.84864399
68	Stomach cancer (HP:0012126)	1.83120095
69	Lissencephaly (HP:0001339)	1.79542488
70	Absent speech (HP:0001344)	1.77884473
71	Oculomotor apraxia (HP:0000657)	1.76714531
72	Disproportionate short-trunk short stature (HP:0003521)	1.74784236
73	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72008852
74	Bile duct proliferation (HP:0001408)	1.71283751
75	Abnormal biliary tract physiology (HP:0012439)	1.71283751
76	Abnormality of renin-angiotensin system (HP:0000847)	1.70265976
77	Protruding tongue (HP:0010808)	1.65590842
78	Stage 5 chronic kidney disease (HP:0003774)	1.60732473
79	Progressive cerebellar ataxia (HP:0002073)	1.60046462
80	Bony spicule pigmentary retinopathy (HP:0007737)	1.59247260
81	Recurrent bronchitis (HP:0002837)	1.57120640
82	Abnormality of macular pigmentation (HP:0008002)	1.56857628
83	Retinitis pigmentosa (HP:0000510)	1.51625538
84	Supernumerary spleens (HP:0009799)	1.50975411
85	Highly arched eyebrow (HP:0002553)	1.50604775
86	Progressive inability to walk (HP:0002505)	1.49413409
87	Median cleft lip (HP:0000161)	1.49341113
88	Inability to walk (HP:0002540)	1.49041880
89	Hyperaldosteronism (HP:0000859)	1.48952686
90	Congenital, generalized hypertrichosis (HP:0004540)	1.48759114
91	Narrow forehead (HP:0000341)	1.48714445
92	Pachygyria (HP:0001302)	1.47331017
93	Aganglionic megacolon (HP:0002251)	1.46728828
94	Abnormality of renal excretion (HP:0011036)	1.45508098
95	Cerebellar dysplasia (HP:0007033)	1.45340582
96	Widely spaced teeth (HP:0000687)	1.45182556
97	Prominent nasal bridge (HP:0000426)	1.44403544
98	Multicystic kidney dysplasia (HP:0000003)	1.43600472
99	Abnormal urine output (HP:0012590)	1.43520645
100	Renal salt wasting (HP:0000127)	1.43434833

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.35674470
2	MAPK15	4.41166135
3	ACVR1B	3.35379751
4	BMPR1B	3.10070671
5	MST4	2.72006311
6	ADRBK2	2.63088830
7	MAP4K2	2.54777956
8	WNK3	2.34979550
9	INSRR	2.28950852
10	GRK1	2.05071170
11	STK39	2.00631232
12	ZAK	1.96722927
13	WNK4	1.88662327
14	NUAK1	1.87636521
15	MAP3K4	1.78699244
16	OXSR1	1.77320778
17	TLK1	1.73600089
18	MAPK13	1.51563449
19	TAOK3	1.44202705
20	MKNK2	1.43205259
21	PAK3	1.41711325
22	BCR	1.30642910
23	ERBB3	1.29983821
24	MARK1	1.27982830
25	ADRBK1	1.27786873
26	CAMKK2	1.25916025
27	EPHA2	1.19798678
28	TGFBR1	1.19092558
29	CASK	1.17167360
30	TNIK	1.14686328
31	PNCK	1.14268176
32	EPHA4	1.11940574
33	PLK4	1.08238953
34	MAPKAPK3	1.04335111
35	BRSK2	1.02979755
36	STK38L	1.02577322
37	STK3	0.99877827
38	MAP3K7	0.96555648
39	PTK2B	0.95504947
40	NEK2	0.92907694
41	TXK	0.91842364
42	TRIM28	0.89229323
43	FER	0.81348459
44	NLK	0.78342567
45	TEC	0.75206963
46	PINK1	0.74266893
47	MAP2K7	0.71542843
48	PRKCE	0.71089284
49	WEE1	0.67375081
50	EPHA3	0.67280782
51	PRKCQ	0.64686980
52	STK11	0.61274268
53	NME1	0.60286482
54	MKNK1	0.55832071
55	AKT3	0.55742349
56	CLK1	0.55311103
57	DYRK2	0.54764963
58	TIE1	0.52760079
59	BRD4	0.52317453
60	STK16	0.51548163
61	IRAK1	0.51322126
62	PRKCI	0.51133565
63	TRPM7	0.51044384
64	MUSK	0.50354598
65	ERBB2	0.49197599
66	PRKAA2	0.48314881
67	EIF2AK3	0.46256842
68	DAPK2	0.45670065
69	LATS1	0.45129258
70	MAP2K1	0.44515289
71	NTRK3	0.43621905
72	SGK2	0.43263607
73	PLK2	0.42429008
74	STK24	0.42036898
75	PRKACA	0.42008630
76	TTK	0.41938468
77	YES1	0.41773361
78	PRKCZ	0.41536840
79	CDK8	0.40260384
80	MAP2K4	0.37992801
81	CHUK	0.37276293
82	PRKCG	0.34249098
83	FGFR2	0.34211687
84	STK10	0.33845756
85	PLK1	0.33829798
86	IKBKB	0.32645795
87	MAPKAPK5	0.31772584
88	CSNK1D	0.30366190
89	CHEK2	0.30354527
90	IGF1R	0.30009570
91	DYRK1A	0.29961592
92	VRK1	0.29726473
93	PKN1	0.29429750
94	CSNK1G2	0.29269581
95	PHKG2	0.28259279
96	PHKG1	0.28259279
97	PRKCA	0.28081000
98	ABL1	0.27447006
99	SGK1	0.26958644
100	ATR	0.26793875

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.34787150
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.94191447
3	Caffeine metabolism_Homo sapiens_hsa00232	2.65806722
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.58739323
5	Chemical carcinogenesis_Homo sapiens_hsa05204	2.51395346
6	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.45988183
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.41608412
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.39292363
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.23626018
10	Phototransduction_Homo sapiens_hsa04744	2.22826326
11	Histidine metabolism_Homo sapiens_hsa00340	2.21766160
12	beta-Alanine metabolism_Homo sapiens_hsa00410	2.17234520
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.06132988
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.02532745
15	Retinol metabolism_Homo sapiens_hsa00830	1.90446032
16	Butanoate metabolism_Homo sapiens_hsa00650	1.84725670
17	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.78426259
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.72359792
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.69460695
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66649818
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.62502749
22	Nicotine addiction_Homo sapiens_hsa05033	1.60895705
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.59650328
24	Basal transcription factors_Homo sapiens_hsa03022	1.56841706
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.55685095
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.55593362
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.55193690
28	ABC transporters_Homo sapiens_hsa02010	1.51472818
29	Huntingtons disease_Homo sapiens_hsa05016	1.48038989
30	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.44001600
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43152766
32	Taste transduction_Homo sapiens_hsa04742	1.40316091
33	Peroxisome_Homo sapiens_hsa04146	1.38789007
34	Homologous recombination_Homo sapiens_hsa03440	1.37957542
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34617089
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29211194
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27202913
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27144665
39	Olfactory transduction_Homo sapiens_hsa04740	1.25456609
40	Propanoate metabolism_Homo sapiens_hsa00640	1.17950009
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05338170
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.03601610
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.03026326
44	Serotonergic synapse_Homo sapiens_hsa04726	1.02131718
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.96975274
46	Salivary secretion_Homo sapiens_hsa04970	0.95941771
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.88952997
48	Fatty acid degradation_Homo sapiens_hsa00071	0.83001737
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.81991792
50	RNA degradation_Homo sapiens_hsa03018	0.80853709
51	RNA polymerase_Homo sapiens_hsa03020	0.80847745
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.80358128
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80061486
54	Sphingolipid metabolism_Homo sapiens_hsa00600	0.79461909
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.76791419
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76665327
57	Circadian rhythm_Homo sapiens_hsa04710	0.75956861
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75717421
59	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.75508969
60	Phenylalanine metabolism_Homo sapiens_hsa00360	0.72208862
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.66217021
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.65812524
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.63817174
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.63222173
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.62349065
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.61895497
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.61630324
68	Oxidative phosphorylation_Homo sapiens_hsa00190	0.59900152
69	Circadian entrainment_Homo sapiens_hsa04713	0.59701085
70	Morphine addiction_Homo sapiens_hsa05032	0.59629921
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55348856
72	Metabolic pathways_Homo sapiens_hsa01100	0.50657727
73	Insulin secretion_Homo sapiens_hsa04911	0.50477962
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50248846
75	Glutathione metabolism_Homo sapiens_hsa00480	0.49085236
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46277123
77	Protein export_Homo sapiens_hsa03060	0.45262532
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45199437
79	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.44356882
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.42642131
81	Cholinergic synapse_Homo sapiens_hsa04725	0.41665942
82	Asthma_Homo sapiens_hsa05310	0.39819709
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.37216413
84	Axon guidance_Homo sapiens_hsa04360	0.36221152
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35722430
86	Pancreatic secretion_Homo sapiens_hsa04972	0.35403880
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35015326
88	Tight junction_Homo sapiens_hsa04530	0.34515550
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.34050468
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33529179
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.33158884
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.32583065
93	Regulation of autophagy_Homo sapiens_hsa04140	0.32360008
94	Purine metabolism_Homo sapiens_hsa00230	0.30682862
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.30413971
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30386474
97	GABAergic synapse_Homo sapiens_hsa04727	0.30271762
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.29715608
99	Mineral absorption_Homo sapiens_hsa04978	0.27659306
100	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.24775595

ZNF440

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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