ZNF441

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)4.23116453
2neural tube formation (GO:0001841)4.05316049
3pyrimidine nucleobase catabolic process (GO:0006208)4.00966929
4cellular ketone body metabolic process (GO:0046950)3.82429363
5regulation of pigment cell differentiation (GO:0050932)3.80231887
6neurotransmitter-gated ion channel clustering (GO:0072578)3.75256071
7developmental pigmentation (GO:0048066)3.68999577
8negative regulation of cytosolic calcium ion concentration (GO:0051481)3.66544062
9nonmotile primary cilium assembly (GO:0035058)3.65915852
10nucleobase catabolic process (GO:0046113)3.58578485
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51746866
12ubiquinone metabolic process (GO:0006743)3.51649625
13ketone body metabolic process (GO:1902224)3.44268878
14protein localization to cilium (GO:0061512)3.39896365
15positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.38614851
16mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.38614851
17startle response (GO:0001964)3.36209528
18glycosphingolipid biosynthetic process (GO:0006688)3.34539103
19presynaptic membrane assembly (GO:0097105)3.33577098
20kidney morphogenesis (GO:0060993)3.29314210
21regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.27532203
22indolalkylamine metabolic process (GO:0006586)3.19440808
23regulation of glucokinase activity (GO:0033131)3.14596365
24regulation of hexokinase activity (GO:1903299)3.14596365
25photoreceptor cell maintenance (GO:0045494)3.13055642
26indole-containing compound catabolic process (GO:0042436)3.06283860
27indolalkylamine catabolic process (GO:0046218)3.06283860
28tryptophan catabolic process (GO:0006569)3.06283860
29behavioral response to ethanol (GO:0048149)3.05288588
30spinal cord motor neuron differentiation (GO:0021522)3.04058002
31DNA double-strand break processing (GO:0000729)3.03494764
32presynaptic membrane organization (GO:0097090)3.02976769
33cilium organization (GO:0044782)3.01559144
34cilium assembly (GO:0042384)3.00774558
35regulation of memory T cell differentiation (GO:0043380)2.97149898
36parental behavior (GO:0060746)2.95751696
37nephron tubule morphogenesis (GO:0072078)2.95399428
38nephron epithelium morphogenesis (GO:0072088)2.95399428
39glutamate receptor signaling pathway (GO:0007215)2.95102795
40brain morphogenesis (GO:0048854)2.89607202
41forebrain neuron differentiation (GO:0021879)2.86641394
42cilium morphogenesis (GO:0060271)2.85803383
43neuron remodeling (GO:0016322)2.82556270
44maternal behavior (GO:0042711)2.79512762
45establishment of protein localization to Golgi (GO:0072600)2.78700382
46inner ear receptor stereocilium organization (GO:0060122)2.78507048
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78254054
48peptidyl-histidine modification (GO:0018202)2.77920390
49regulation of action potential (GO:0098900)2.76148217
50detection of light stimulus involved in visual perception (GO:0050908)2.75636743
51detection of light stimulus involved in sensory perception (GO:0050962)2.75636743
52intraciliary transport (GO:0042073)2.71534548
53central nervous system neuron axonogenesis (GO:0021955)2.71028862
54neuron cell-cell adhesion (GO:0007158)2.70008312
55gamma-aminobutyric acid transport (GO:0015812)2.68491971
56platelet dense granule organization (GO:0060155)2.68452481
57tryptophan metabolic process (GO:0006568)2.65691980
58protein K11-linked deubiquitination (GO:0035871)2.64387041
59neuronal action potential (GO:0019228)2.63276940
60central nervous system projection neuron axonogenesis (GO:0021952)2.62160420
61proline transport (GO:0015824)2.60674863
62kynurenine metabolic process (GO:0070189)2.59191324
63neuron maturation (GO:0042551)2.58352625
64tachykinin receptor signaling pathway (GO:0007217)2.58244862
65positive regulation of oligodendrocyte differentiation (GO:0048714)2.58188794
66renal tubule morphogenesis (GO:0061333)2.57915626
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57710685
68cilium or flagellum-dependent cell motility (GO:0001539)2.56823078
69positive regulation of macroautophagy (GO:0016239)2.56314056
70neuron fate determination (GO:0048664)2.55468060
71calcium ion-dependent exocytosis (GO:0017156)2.54991722
72negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53992873
73negative regulation of translation, ncRNA-mediated (GO:0040033)2.53992873
74regulation of translation, ncRNA-mediated (GO:0045974)2.53992873
75righting reflex (GO:0060013)2.51590281
76histone H3-K4 trimethylation (GO:0080182)2.51074953
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.50491107
78myelin assembly (GO:0032288)2.50345804
79cellular component assembly involved in morphogenesis (GO:0010927)2.50147684
80dendritic spine morphogenesis (GO:0060997)2.49696507
81reflex (GO:0060004)2.49578742
82interkinetic nuclear migration (GO:0022027)2.48814929
83axoneme assembly (GO:0035082)2.48178607
84negative regulation of cAMP-mediated signaling (GO:0043951)2.47351398
85keratinocyte development (GO:0003334)2.45097485
86positive regulation of neurological system process (GO:0031646)2.45044774
87inositol phosphate catabolic process (GO:0071545)2.44810628
88retinal ganglion cell axon guidance (GO:0031290)2.44595607
89behavioral response to nicotine (GO:0035095)2.42768373
90positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42608265
91detection of calcium ion (GO:0005513)2.41255739
92cholesterol biosynthetic process (GO:0006695)2.40885270
93regulation of Rac GTPase activity (GO:0032314)2.40842328
94positive regulation of skeletal muscle tissue development (GO:0048643)2.40130855
95positive regulation of mitotic sister chromatid separation (GO:1901970)2.39555806
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.39555806
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.39555806
98protein-cofactor linkage (GO:0018065)2.39193025
99auditory receptor cell stereocilium organization (GO:0060088)2.37544306
100epithelial cilium movement (GO:0003351)2.37197985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.27798101
2ZNF274_21170338_ChIP-Seq_K562_Hela3.12598704
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.04157653
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.93491474
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88890131
6VDR_22108803_ChIP-Seq_LS180_Human2.66042671
7EZH2_22144423_ChIP-Seq_EOC_Human2.48913551
8TAF15_26573619_Chip-Seq_HEK293_Human2.44576680
9IGF1R_20145208_ChIP-Seq_DFB_Human2.42382784
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35802296
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35543982
12FUS_26573619_Chip-Seq_HEK293_Human2.22446985
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.17218021
14P300_19829295_ChIP-Seq_ESCs_Human2.11590761
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10643372
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.09707853
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09067093
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02773709
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97977279
20EWS_26573619_Chip-Seq_HEK293_Human1.93234347
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93189973
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88916426
23ER_23166858_ChIP-Seq_MCF-7_Human1.86282461
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83361793
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.82404485
26SMAD4_21799915_ChIP-Seq_A2780_Human1.78991867
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76179386
28STAT3_23295773_ChIP-Seq_U87_Human1.75095739
29BCAT_22108803_ChIP-Seq_LS180_Human1.71952771
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70670616
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70311698
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67935862
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67541116
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64218659
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63947705
36CBP_20019798_ChIP-Seq_JUKART_Human1.63947705
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61894440
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57470758
39AR_25329375_ChIP-Seq_VCAP_Human1.54751592
40TCF4_23295773_ChIP-Seq_U87_Human1.54010089
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52302585
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.52177315
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52131195
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.51803882
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51719932
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.51704536
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51468813
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49503908
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49503908
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.46572424
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.44977328
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43638476
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.42938125
54P53_22387025_ChIP-Seq_ESCs_Mouse1.35570308
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.35270177
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31997726
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31449457
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.30607927
59TCF4_22108803_ChIP-Seq_LS180_Human1.30594329
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30455040
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30436284
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28870491
63REST_21632747_ChIP-Seq_MESCs_Mouse1.27802137
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.25844713
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25461441
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24587617
67RUNX2_22187159_ChIP-Seq_PCA_Human1.23729306
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.23185565
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23158387
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22142958
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.21516994
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21336858
73* TP53_22573176_ChIP-Seq_HFKS_Human1.20344266
74RNF2_27304074_Chip-Seq_NSC_Mouse1.20339871
75TP53_16413492_ChIP-PET_HCT116_Human1.17621917
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17156932
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17153528
78CDX2_22108803_ChIP-Seq_LS180_Human1.16573766
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15017369
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14167112
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14089598
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.13986021
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.13879810
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12785587
85AR_21572438_ChIP-Seq_LNCaP_Human1.12451893
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10339369
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10180056
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10180056
89P300_18555785_Chip-Seq_ESCs_Mouse1.09946011
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07432464
91TP53_18474530_ChIP-ChIP_U2OS_Human1.07080769
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07059109
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.06940792
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06725409
95KDM2B_26808549_Chip-Seq_REH_Human1.04967619
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.04558730
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.04517808
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03845587
99JUN_21703547_ChIP-Seq_K562_Human0.99753938
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99010405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.30538942
2MP0000569_abnormal_digit_pigmentation3.16882931
3MP0004270_analgesia2.74336017
4MP0001529_abnormal_vocalization2.74203220
5MP0000015_abnormal_ear_pigmentation2.68683782
6MP0002837_dystrophic_cardiac_calcinosis2.64842343
7MP0005174_abnormal_tail_pigmentation2.57620733
8MP0001968_abnormal_touch/_nociception2.31953531
9MP0003195_calcinosis2.24049716
10MP0005187_abnormal_penis_morphology2.17278127
11MP0002638_abnormal_pupillary_reflex2.15148026
12MP0001188_hyperpigmentation2.12085398
13MP0003880_abnormal_central_pattern2.11895507
14MP0009046_muscle_twitch2.09536208
15MP0010386_abnormal_urinary_bladder2.07823314
16MP0003122_maternal_imprinting2.07676496
17MP0003787_abnormal_imprinting2.06463280
18MP0005551_abnormal_eye_electrophysiolog2.03234955
19MP0001984_abnormal_olfaction2.01304987
20MP0009745_abnormal_behavioral_response1.94450155
21MP0002102_abnormal_ear_morphology1.92498448
22MP0005646_abnormal_pituitary_gland1.76256597
23MP0005386_behavior/neurological_phenoty1.71960255
24MP0004924_abnormal_behavior1.71960255
25MP0002272_abnormal_nervous_system1.70311993
26MP0003121_genomic_imprinting1.69042480
27MP0000372_irregular_coat_pigmentation1.66884880
28MP0000778_abnormal_nervous_system1.66110833
29MP0001486_abnormal_startle_reflex1.65287738
30MP0006276_abnormal_autonomic_nervous1.62736193
31MP0002736_abnormal_nociception_after1.59435714
32MP0002064_seizures1.57719638
33MP0004885_abnormal_endolymph1.56892925
34MP0005409_darkened_coat_color1.56847525
35MP0000647_abnormal_sebaceous_gland1.56594272
36MP0001501_abnormal_sleep_pattern1.55112355
37MP0006072_abnormal_retinal_apoptosis1.52931783
38MP0005253_abnormal_eye_physiology1.52629388
39MP0002095_abnormal_skin_pigmentation1.52276772
40MP0002735_abnormal_chemical_nociception1.51993206
41MP0003635_abnormal_synaptic_transmissio1.50186928
42MP0005248_abnormal_Harderian_gland1.46016328
43MP0008877_abnormal_DNA_methylation1.44738742
44MP0003136_yellow_coat_color1.44022485
45MP0004133_heterotaxia1.43287059
46MP0002876_abnormal_thyroid_physiology1.43233132
47MP0005645_abnormal_hypothalamus_physiol1.39442277
48MP0000631_abnormal_neuroendocrine_gland1.31446577
49MP0005075_abnormal_melanosome_morpholog1.30692940
50MP0002067_abnormal_sensory_capabilities1.29656609
51MP0002938_white_spotting1.27357486
52MP0002734_abnormal_mechanical_nocicepti1.26724066
53MP0002928_abnormal_bile_duct1.25747932
54MP0002909_abnormal_adrenal_gland1.24843645
55MP0002572_abnormal_emotion/affect_behav1.23946073
56MP0002557_abnormal_social/conspecific_i1.23324755
57MP0004859_abnormal_synaptic_plasticity1.23165208
58MP0005379_endocrine/exocrine_gland_phen1.20940395
59MP0005085_abnormal_gallbladder_physiolo1.20680416
60MP0002063_abnormal_learning/memory/cond1.19348452
61MP0001485_abnormal_pinna_reflex1.15551853
62MP0004742_abnormal_vestibular_system1.15367805
63MP0009379_abnormal_foot_pigmentation1.13834706
64MP0005084_abnormal_gallbladder_morpholo1.13155995
65MP0001986_abnormal_taste_sensitivity1.12962608
66MP0004142_abnormal_muscle_tone1.10153444
67MP0002184_abnormal_innervation1.08890239
68MP0004147_increased_porphyrin_level1.07422811
69MP0001970_abnormal_pain_threshold1.06529775
70MP0000427_abnormal_hair_cycle1.05490105
71MP0002733_abnormal_thermal_nociception1.03488968
72MP0002229_neurodegeneration1.02267201
73MP0002234_abnormal_pharynx_morphology1.02039770
74MP0004043_abnormal_pH_regulation1.00054016
75MP0004215_abnormal_myocardial_fiber0.95766449
76MP0002751_abnormal_autonomic_nervous0.95474449
77MP0002882_abnormal_neuron_morphology0.93049607
78MP0005310_abnormal_salivary_gland0.91894204
79MP0000383_abnormal_hair_follicle0.91419507
80MP0005367_renal/urinary_system_phenotyp0.91083503
81MP0000516_abnormal_urinary_system0.91083503
82MP0000955_abnormal_spinal_cord0.89678533
83MP0009697_abnormal_copulation0.88752466
84MP0005410_abnormal_fertilization0.87018381
85MP0000538_abnormal_urinary_bladder0.86497233
86MP0002139_abnormal_hepatobiliary_system0.85574992
87MP0005195_abnormal_posterior_eye0.84675021
88MP0005266_abnormal_metabolism0.84227974
89MP0002693_abnormal_pancreas_physiology0.84011576
90MP0003633_abnormal_nervous_system0.83761890
91MP0005423_abnormal_somatic_nervous0.83115214
92MP0001944_abnormal_pancreas_morphology0.82268287
93MP0000371_diluted_coat_color0.81478907
94MP0004085_abnormal_heartbeat0.81434429
95MP0008872_abnormal_physiological_respon0.80911765
96MP0009780_abnormal_chondrocyte_physiolo0.79897481
97MP0002752_abnormal_somatic_nervous0.78663357
98MP0002127_abnormal_cardiovascular_syste0.78075803
99MP0001324_abnormal_eye_pigmentation0.77362885
100MP0010329_abnormal_lipoprotein_level0.77336776

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.46855688
2Pancreatic fibrosis (HP:0100732)4.10721518
3True hermaphroditism (HP:0010459)3.98638695
4Chronic hepatic failure (HP:0100626)3.97156076
5Febrile seizures (HP:0002373)3.88124544
6Hypothermia (HP:0002045)3.83413567
7Nephronophthisis (HP:0000090)3.53690940
8Pheochromocytoma (HP:0002666)3.52295814
9Neuroendocrine neoplasm (HP:0100634)3.39609779
10Papillary thyroid carcinoma (HP:0002895)3.36149447
11Volvulus (HP:0002580)3.23598549
12Hyperventilation (HP:0002883)3.23160978
13Medial flaring of the eyebrow (HP:0010747)3.21773990
14Molar tooth sign on MRI (HP:0002419)3.19981074
15Abnormality of midbrain morphology (HP:0002418)3.19981074
16Abnormality of the renal medulla (HP:0100957)3.17293156
17Gaze-evoked nystagmus (HP:0000640)3.14337233
18Renal cortical cysts (HP:0000803)3.10294460
19Abnormality of the renal cortex (HP:0011035)2.92793438
20Focal seizures (HP:0007359)2.86265699
21Dialeptic seizures (HP:0011146)2.65737682
22Atonic seizures (HP:0010819)2.64745636
23Intestinal atresia (HP:0011100)2.62113625
24Gait imbalance (HP:0002141)2.62054685
25Hemiparesis (HP:0001269)2.60696774
26Cystic liver disease (HP:0006706)2.59217878
27Tachypnea (HP:0002789)2.57538242
28Abnormal biliary tract physiology (HP:0012439)2.51320004
29Bile duct proliferation (HP:0001408)2.51320004
30Congenital primary aphakia (HP:0007707)2.48987840
31Buphthalmos (HP:0000557)2.45718910
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.44467867
33Absent speech (HP:0001344)2.44054554
34Thyroid carcinoma (HP:0002890)2.43469198
35Absence seizures (HP:0002121)2.40438376
36Focal motor seizures (HP:0011153)2.39366135
37Drooling (HP:0002307)2.39014427
38Furrowed tongue (HP:0000221)2.39005585
39Congenital hepatic fibrosis (HP:0002612)2.31956297
40Fair hair (HP:0002286)2.28062435
41Progressive cerebellar ataxia (HP:0002073)2.26295763
42Neoplasm of the oral cavity (HP:0100649)2.25122564
43Exotropia (HP:0000577)2.23907786
44Male pseudohermaphroditism (HP:0000037)2.22401981
45Epidermoid cyst (HP:0200040)2.20393150
46Excessive salivation (HP:0003781)2.19399221
47Large for gestational age (HP:0001520)2.17850839
48Congenital stationary night blindness (HP:0007642)2.16778486
49Broad-based gait (HP:0002136)2.15441486
50Nephrogenic diabetes insipidus (HP:0009806)2.13006614
51Genital tract atresia (HP:0001827)2.12786166
52Widely spaced teeth (HP:0000687)2.11949498
53Sclerocornea (HP:0000647)2.11449060
54Metaphyseal dysplasia (HP:0100255)2.07780134
55Attenuation of retinal blood vessels (HP:0007843)2.07397377
56Postaxial hand polydactyly (HP:0001162)2.06713493
57Proximal tubulopathy (HP:0000114)2.06636763
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.05886078
59Facial hemangioma (HP:0000329)2.05000091
60Narrow forehead (HP:0000341)2.01543407
61Limb dystonia (HP:0002451)2.01439856
62Specific learning disability (HP:0001328)2.01404615
63Congenital sensorineural hearing impairment (HP:0008527)2.01096524
64Anencephaly (HP:0002323)2.00696963
65Hamartoma of the eye (HP:0010568)2.00657151
66Progressive inability to walk (HP:0002505)2.00152740
67Type II lissencephaly (HP:0007260)1.99771314
68Megalencephaly (HP:0001355)1.98522630
69Vaginal atresia (HP:0000148)1.96054303
70Tubulointerstitial nephritis (HP:0001970)1.93199955
71Inability to walk (HP:0002540)1.92861102
72Postaxial foot polydactyly (HP:0001830)1.92344682
73Thyroid-stimulating hormone excess (HP:0002925)1.90489712
74Pachygyria (HP:0001302)1.89701720
75Neoplasm of the peripheral nervous system (HP:0100007)1.88121333
76Choroideremia (HP:0001139)1.88028409
77Amyotrophic lateral sclerosis (HP:0007354)1.86191986
78Generalized tonic-clonic seizures (HP:0002069)1.84343222
79Poor coordination (HP:0002370)1.82118673
80Abnormality of macular pigmentation (HP:0008002)1.80214887
81Abnormality of the labia minora (HP:0012880)1.77752201
82Neonatal respiratory distress (HP:0002643)1.77518887
83Lissencephaly (HP:0001339)1.76781988
84Hyperkalemia (HP:0002153)1.76279684
85Stomach cancer (HP:0012126)1.75357528
86Methylmalonic acidemia (HP:0002912)1.72901716
87Abolished electroretinogram (ERG) (HP:0000550)1.72446094
88Polyphagia (HP:0002591)1.71941499
89Aplasia/Hypoplasia of the lens (HP:0008063)1.71834909
90Abnormal drinking behavior (HP:0030082)1.71316462
91Polydipsia (HP:0001959)1.71316462
92Limb hypertonia (HP:0002509)1.69752898
93Highly arched eyebrow (HP:0002553)1.69570460
94Palpitations (HP:0001962)1.69551954
95Astrocytoma (HP:0009592)1.69400872
96Abnormality of the astrocytes (HP:0100707)1.69400872
97Aqueductal stenosis (HP:0002410)1.68906359
98Zonular cataract (HP:0010920)1.68734077
99Abnormality of the ischium (HP:0003174)1.68101797
100Ketoacidosis (HP:0001993)1.66283534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.45580988
2EEF2K3.34269934
3MAPK133.06624243
4WNK32.94504309
5CASK2.93117029
6MAP3K42.84560169
7PINK12.78684978
8MAPKAPK32.64100067
9NTRK32.56385836
10TRIM282.55513826
11ERBB32.32239670
12TRPM72.25921790
13MARK12.17979364
14ADRBK22.04991030
15MAP2K71.90630258
16MAP4K21.85497746
17NUAK11.81366868
18ACVR1B1.64913960
19TNIK1.61380756
20PAK31.61070120
21BCR1.56918216
22BMPR1B1.56584535
23STK391.54357488
24EIF2AK31.43684466
25MAPKAPK51.39423421
26LATS11.36156113
27WNK41.30256800
28PNCK1.28538627
29OXSR11.26423159
30FGFR21.25910242
31MKNK21.19739113
32GRK11.11405947
33AKT31.10738478
34CAMKK21.04238622
35INSRR1.04026855
36MAP2K41.03785325
37CSNK1G20.98781050
38NTRK20.98499033
39PRKCE0.97392305
40SIK30.97160036
41STK30.97029745
42CCNB10.89965038
43FGFR30.82052473
44MKNK10.79251292
45YES10.77715493
46TAF10.74753509
47PRKCG0.74096760
48PLK20.73523057
49KSR10.72289274
50SIK20.70866956
51PRKAA10.69302405
52CSNK1G30.66760285
53BMPR20.66667999
54VRK10.66036639
55EPHA30.66035242
56STK110.65565506
57PTK2B0.65490126
58CSNK1G10.64567977
59DYRK1A0.64377242
60CSNK1A1L0.62584232
61RPS6KB20.61611062
62MAPK110.61189899
63BRSK20.59717511
64TNK20.56559263
65FER0.55826140
66ADRBK10.55809045
67MINK10.54168523
68TAOK10.50815594
69PRKAA20.50600110
70PHKG10.50281766
71PHKG20.50281766
72DAPK20.50028183
73MAP3K20.49943319
74PKN10.49926280
75MAP3K70.49567384
76STK38L0.49162541
77NLK0.47789715
78DYRK20.46377026
79TAOK30.46117206
80PIK3CG0.45166608
81CAMK2A0.44132107
82PRKG10.42979461
83NEK10.42755004
84PRKACB0.42314950
85OBSCN0.39568310
86MARK30.39540639
87TEC0.39399428
88CDC70.38559036
89CDK50.36435016
90RPS6KB10.35449335
91PRKACA0.34576298
92CSNK1D0.34097527
93MUSK0.34038563
94PAK60.33729270
95PRKCZ0.32878443
96EPHA40.32441696
97SGK20.30797683
98MAPK120.29494322
99CSNK1A10.29290456
100DYRK30.27433715

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.40940305
2Nicotine addiction_Homo sapiens_hsa050332.80860609
3Butanoate metabolism_Homo sapiens_hsa006502.69595199
4Protein export_Homo sapiens_hsa030602.50693076
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.36983272
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.34737485
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18076984
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17014884
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.09896840
10Taste transduction_Homo sapiens_hsa047422.04926319
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87587984
12GABAergic synapse_Homo sapiens_hsa047271.85783716
13Circadian entrainment_Homo sapiens_hsa047131.80076996
14Phototransduction_Homo sapiens_hsa047441.75139979
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74665321
16Morphine addiction_Homo sapiens_hsa050321.66026951
17Insulin secretion_Homo sapiens_hsa049111.63859002
18Circadian rhythm_Homo sapiens_hsa047101.63718907
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63080692
20Collecting duct acid secretion_Homo sapiens_hsa049661.60267254
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59853457
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57112423
23Dopaminergic synapse_Homo sapiens_hsa047281.53277546
24Caffeine metabolism_Homo sapiens_hsa002321.47717593
25Nitrogen metabolism_Homo sapiens_hsa009101.47268682
26ABC transporters_Homo sapiens_hsa020101.46502144
27Tryptophan metabolism_Homo sapiens_hsa003801.45070305
28Glutamatergic synapse_Homo sapiens_hsa047241.44818086
29Regulation of autophagy_Homo sapiens_hsa041401.40869840
30Serotonergic synapse_Homo sapiens_hsa047261.39325041
31Peroxisome_Homo sapiens_hsa041461.38663242
32Basal transcription factors_Homo sapiens_hsa030221.37720446
33Propanoate metabolism_Homo sapiens_hsa006401.36624999
34Olfactory transduction_Homo sapiens_hsa047401.24038801
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21312161
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21310532
37Salivary secretion_Homo sapiens_hsa049701.20984757
38Ether lipid metabolism_Homo sapiens_hsa005651.18833151
39Cholinergic synapse_Homo sapiens_hsa047251.15508080
40Steroid biosynthesis_Homo sapiens_hsa001001.12858543
41Linoleic acid metabolism_Homo sapiens_hsa005911.06972856
42Renin secretion_Homo sapiens_hsa049241.06178226
43Selenocompound metabolism_Homo sapiens_hsa004501.05905816
44Cocaine addiction_Homo sapiens_hsa050301.00791572
45Synaptic vesicle cycle_Homo sapiens_hsa047210.99699012
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98415519
47Amphetamine addiction_Homo sapiens_hsa050310.97680894
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96144893
49Long-term depression_Homo sapiens_hsa047300.95742797
50Calcium signaling pathway_Homo sapiens_hsa040200.95236565
51beta-Alanine metabolism_Homo sapiens_hsa004100.92677963
52Sphingolipid metabolism_Homo sapiens_hsa006000.91915453
53Vitamin B6 metabolism_Homo sapiens_hsa007500.88206096
54Retinol metabolism_Homo sapiens_hsa008300.88183053
55Fanconi anemia pathway_Homo sapiens_hsa034600.86325663
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86321362
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.82736601
58Fatty acid degradation_Homo sapiens_hsa000710.81613309
59Oxytocin signaling pathway_Homo sapiens_hsa049210.78989363
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78937417
61cAMP signaling pathway_Homo sapiens_hsa040240.77198158
62Lysine degradation_Homo sapiens_hsa003100.75986617
63Gastric acid secretion_Homo sapiens_hsa049710.74861933
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74750520
65Inositol phosphate metabolism_Homo sapiens_hsa005620.69583821
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69489305
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60235762
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.59344919
69Fatty acid elongation_Homo sapiens_hsa000620.58770979
70Histidine metabolism_Homo sapiens_hsa003400.57442380
71Oxidative phosphorylation_Homo sapiens_hsa001900.57231489
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57001226
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56144021
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55823456
75Chemical carcinogenesis_Homo sapiens_hsa052040.55024688
76Axon guidance_Homo sapiens_hsa043600.54929444
77Glycerolipid metabolism_Homo sapiens_hsa005610.53579796
78Dorso-ventral axis formation_Homo sapiens_hsa043200.52656434
79Estrogen signaling pathway_Homo sapiens_hsa049150.52650960
80Type II diabetes mellitus_Homo sapiens_hsa049300.49800104
81Alcoholism_Homo sapiens_hsa050340.49728662
82Non-homologous end-joining_Homo sapiens_hsa034500.48176137
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48079741
84Vibrio cholerae infection_Homo sapiens_hsa051100.45192308
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.44116456
86Long-term potentiation_Homo sapiens_hsa047200.43464967
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43330023
88Fatty acid metabolism_Homo sapiens_hsa012120.42284675
89Ovarian steroidogenesis_Homo sapiens_hsa049130.40823488
90Glucagon signaling pathway_Homo sapiens_hsa049220.40716317
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39530282
92AMPK signaling pathway_Homo sapiens_hsa041520.38378232
93Pancreatic secretion_Homo sapiens_hsa049720.37673413
94Fat digestion and absorption_Homo sapiens_hsa049750.36557832
95Bile secretion_Homo sapiens_hsa049760.30654556
96Prolactin signaling pathway_Homo sapiens_hsa049170.29753054
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28635546
98Oocyte meiosis_Homo sapiens_hsa041140.27899715
99Hedgehog signaling pathway_Homo sapiens_hsa043400.27469033
100Sulfur metabolism_Homo sapiens_hsa009200.26295304

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »