ZNF442

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.83696739
2protein K11-linked deubiquitination (GO:0035871)3.94286662
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86676881
4fucose catabolic process (GO:0019317)3.77630299
5L-fucose metabolic process (GO:0042354)3.77630299
6L-fucose catabolic process (GO:0042355)3.77630299
7detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.72379686
8indolalkylamine metabolic process (GO:0006586)3.71935433
9platelet dense granule organization (GO:0060155)3.67268171
10indole-containing compound catabolic process (GO:0042436)3.60145971
11indolalkylamine catabolic process (GO:0046218)3.60145971
12tryptophan catabolic process (GO:0006569)3.60145971
13cellular ketone body metabolic process (GO:0046950)3.58868525
14epithelial cilium movement (GO:0003351)3.46559462
15neural tube formation (GO:0001841)3.46099119
16ketone body metabolic process (GO:1902224)3.45103087
17response to pheromone (GO:0019236)3.41708329
18water-soluble vitamin biosynthetic process (GO:0042364)3.40280899
19DNA deamination (GO:0045006)3.38063387
20kynurenine metabolic process (GO:0070189)3.30286253
21preassembly of GPI anchor in ER membrane (GO:0016254)3.28065209
22cilium morphogenesis (GO:0060271)3.24440296
23tryptophan metabolic process (GO:0006568)3.20754702
24detection of light stimulus involved in visual perception (GO:0050908)3.17795872
25detection of light stimulus involved in sensory perception (GO:0050962)3.17795872
26piRNA metabolic process (GO:0034587)3.16927023
27axoneme assembly (GO:0035082)3.13636643
28dopamine transport (GO:0015872)3.00953673
29respiratory chain complex IV assembly (GO:0008535)3.00667472
30regulation of cilium movement (GO:0003352)2.97055348
31somite development (GO:0061053)2.94350791
32cilium movement (GO:0003341)2.90726696
33NADH dehydrogenase complex assembly (GO:0010257)2.90692049
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90692049
35mitochondrial respiratory chain complex I assembly (GO:0032981)2.90692049
36protein complex biogenesis (GO:0070271)2.89062904
37establishment of protein localization to Golgi (GO:0072600)2.88824906
38regulation of meiosis I (GO:0060631)2.88562813
39negative regulation of mast cell activation (GO:0033004)2.84546219
40regulation of hexokinase activity (GO:1903299)2.82000634
41regulation of glucokinase activity (GO:0033131)2.82000634
42prenylation (GO:0097354)2.81739131
43protein prenylation (GO:0018342)2.81739131
44negative regulation of translation, ncRNA-mediated (GO:0040033)2.80859144
45regulation of translation, ncRNA-mediated (GO:0045974)2.80859144
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80859144
47cellular biogenic amine catabolic process (GO:0042402)2.80156119
48amine catabolic process (GO:0009310)2.80156119
49protein polyglutamylation (GO:0018095)2.76835220
50photoreceptor cell maintenance (GO:0045494)2.74902799
51cilium organization (GO:0044782)2.70181989
52protein localization to cilium (GO:0061512)2.68956273
53pyrimidine nucleobase catabolic process (GO:0006208)2.68928701
54protein-cofactor linkage (GO:0018065)2.68682664
55reflex (GO:0060004)2.68331709
56regulation of neurotransmitter uptake (GO:0051580)2.67670634
57indole-containing compound metabolic process (GO:0042430)2.66790186
58negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64898212
59mannosylation (GO:0097502)2.64433297
60cilium assembly (GO:0042384)2.62534007
61behavioral response to ethanol (GO:0048149)2.62359130
62intraciliary transport (GO:0042073)2.61803991
63DNA methylation involved in gamete generation (GO:0043046)2.60890204
64anterograde synaptic vesicle transport (GO:0048490)2.59622455
65mitochondrial respiratory chain complex assembly (GO:0033108)2.58585972
66cytochrome complex assembly (GO:0017004)2.57901456
67photoreceptor cell development (GO:0042461)2.57372831
68regulation of action potential (GO:0098900)2.56939004
69cilium or flagellum-dependent cell motility (GO:0001539)2.56825874
70S-adenosylmethionine metabolic process (GO:0046500)2.55034108
71GPI anchor metabolic process (GO:0006505)2.51964985
72gamma-aminobutyric acid transport (GO:0015812)2.50801426
73nonmotile primary cilium assembly (GO:0035058)2.50751046
74multicellular organism reproduction (GO:0032504)2.49055230
75kidney morphogenesis (GO:0060993)2.47240764
76adaptation of signaling pathway (GO:0023058)2.46607097
77regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.44580768
78rRNA catabolic process (GO:0016075)2.44497062
79sulfation (GO:0051923)2.43755731
80protein targeting to Golgi (GO:0000042)2.43736937
81retinal cone cell development (GO:0046549)2.43643438
82protein K63-linked deubiquitination (GO:0070536)2.43512322
83reciprocal DNA recombination (GO:0035825)2.43266302
84reciprocal meiotic recombination (GO:0007131)2.43266302
85recombinational repair (GO:0000725)2.43080969
86replication fork processing (GO:0031297)2.42605310
87double-strand break repair via homologous recombination (GO:0000724)2.41707790
88oxidative demethylation (GO:0070989)2.41297537
89drug catabolic process (GO:0042737)2.41287517
90cornea development in camera-type eye (GO:0061303)2.41186652
91embryonic epithelial tube formation (GO:0001838)2.40057530
92protein localization to Golgi apparatus (GO:0034067)2.38747430
93nucleobase catabolic process (GO:0046113)2.35614240
94regulation of hippo signaling (GO:0035330)2.35405410
95signal peptide processing (GO:0006465)2.35117351
96heme transport (GO:0015886)2.33916280
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33879269
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.33769012
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.33769012
100exogenous drug catabolic process (GO:0042738)2.32562068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.41591804
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24056049
3VDR_22108803_ChIP-Seq_LS180_Human3.05277953
4GBX2_23144817_ChIP-Seq_PC3_Human3.02214112
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75057234
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67773417
7IGF1R_20145208_ChIP-Seq_DFB_Human2.49995583
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41890928
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.38937470
10FUS_26573619_Chip-Seq_HEK293_Human2.28044090
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.22600482
12P300_19829295_ChIP-Seq_ESCs_Human2.20732555
13TAF15_26573619_Chip-Seq_HEK293_Human2.14626605
14EWS_26573619_Chip-Seq_HEK293_Human2.11444902
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07065845
16ER_23166858_ChIP-Seq_MCF-7_Human2.06633684
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06266835
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01744823
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94619205
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87234524
21EZH2_22144423_ChIP-Seq_EOC_Human1.83870309
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79595640
23CBP_20019798_ChIP-Seq_JUKART_Human1.73576137
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73576137
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72030381
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.71564843
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69663401
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68146919
29SMAD4_21799915_ChIP-Seq_A2780_Human1.67914444
30* STAT3_23295773_ChIP-Seq_U87_Human1.63648074
31BCAT_22108803_ChIP-Seq_LS180_Human1.57698014
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57045233
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55606352
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55049245
35AR_25329375_ChIP-Seq_VCAP_Human1.51104998
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50366183
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.49717705
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48788411
39TCF4_23295773_ChIP-Seq_U87_Human1.48758833
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48367255
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48118105
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46957547
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46567038
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44056862
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43949502
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.43511476
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41507518
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41365120
49IRF1_19129219_ChIP-ChIP_H3396_Human1.41172892
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40862693
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.40563754
52TCF4_22108803_ChIP-Seq_LS180_Human1.38026092
53NANOG_19829295_ChIP-Seq_ESCs_Human1.37923220
54SOX2_19829295_ChIP-Seq_ESCs_Human1.37923220
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.36659553
56TP53_22573176_ChIP-Seq_HFKS_Human1.35826537
57AR_21572438_ChIP-Seq_LNCaP_Human1.35387264
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35002054
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34049461
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34049461
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32723523
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.31246419
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30616329
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.28679993
65CDX2_22108803_ChIP-Seq_LS180_Human1.28455670
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27734167
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.27428662
68RUNX2_22187159_ChIP-Seq_PCA_Human1.26676008
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26459209
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25715615
71ELK1_19687146_ChIP-ChIP_HELA_Human1.24950638
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21619658
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.21417947
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20728471
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.19610772
76P53_22387025_ChIP-Seq_ESCs_Mouse1.16446810
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.16024493
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15616119
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.12881060
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12881060
81RNF2_27304074_Chip-Seq_NSC_Mouse1.10366568
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.09202581
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08786409
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08298063
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07256852
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06727988
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.06532207
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06408508
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.05832867
90MYC_18940864_ChIP-ChIP_HL60_Human1.05786839
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04297276
92TP53_16413492_ChIP-PET_HCT116_Human1.03822519
93AR_20517297_ChIP-Seq_VCAP_Human1.02783230
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02566678
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02058812
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.01775807
97HOXB7_26014856_ChIP-Seq_BT474_Human1.01621894
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01162331
99ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01133434
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00154387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.88229567
2MP0003195_calcinosis3.43444178
3MP0008877_abnormal_DNA_methylation3.39952132
4MP0000372_irregular_coat_pigmentation2.87665125
5MP0003646_muscle_fatigue2.82867195
6MP0003787_abnormal_imprinting2.60787747
7MP0002102_abnormal_ear_morphology2.59009238
8MP0005551_abnormal_eye_electrophysiolog2.44861725
9MP0003136_yellow_coat_color2.33278650
10MP0002837_dystrophic_cardiac_calcinosis2.12576942
11MP0005646_abnormal_pituitary_gland2.11568156
12MP0000427_abnormal_hair_cycle2.04220212
13MP0005253_abnormal_eye_physiology2.03918498
14MP0001984_abnormal_olfaction1.92651396
15MP0006072_abnormal_retinal_apoptosis1.90437830
16MP0004142_abnormal_muscle_tone1.89403283
17MP0002876_abnormal_thyroid_physiology1.88535950
18MP0005174_abnormal_tail_pigmentation1.85010710
19MP0002638_abnormal_pupillary_reflex1.79784181
20MP0006276_abnormal_autonomic_nervous1.79115004
21MP0003011_delayed_dark_adaptation1.73099748
22MP0006292_abnormal_olfactory_placode1.70336327
23MP0009046_muscle_twitch1.68886328
24MP0008995_early_reproductive_senescence1.65325221
25MP0005084_abnormal_gallbladder_morpholo1.60958126
26MP0005645_abnormal_hypothalamus_physiol1.60371488
27MP0008875_abnormal_xenobiotic_pharmacok1.56288437
28MP0001501_abnormal_sleep_pattern1.54968795
29MP0003880_abnormal_central_pattern1.51910720
30MP0005075_abnormal_melanosome_morpholog1.49519739
31MP0001485_abnormal_pinna_reflex1.48864532
32MP0002928_abnormal_bile_duct1.47486432
33MP0001968_abnormal_touch/_nociception1.47163095
34MP0008872_abnormal_physiological_respon1.44941332
35MP0002938_white_spotting1.43296181
36MP0009745_abnormal_behavioral_response1.42550697
37MP0003121_genomic_imprinting1.41544477
38MP0001486_abnormal_startle_reflex1.40779430
39MP0004043_abnormal_pH_regulation1.38463021
40MP0000383_abnormal_hair_follicle1.36329160
41MP0002138_abnormal_hepatobiliary_system1.36073516
42MP0004133_heterotaxia1.33994819
43MP0000631_abnormal_neuroendocrine_gland1.33849495
44MP0005187_abnormal_penis_morphology1.31508011
45MP0002095_abnormal_skin_pigmentation1.31481481
46MP0001986_abnormal_taste_sensitivity1.31311564
47MP0010386_abnormal_urinary_bladder1.31031376
48MP0002272_abnormal_nervous_system1.29895260
49MP0004885_abnormal_endolymph1.29671043
50MP0003950_abnormal_plasma_membrane1.28031914
51MP0003122_maternal_imprinting1.25710790
52MP0000015_abnormal_ear_pigmentation1.24137436
53MP0002736_abnormal_nociception_after1.22937633
54MP0001324_abnormal_eye_pigmentation1.17818823
55MP0005389_reproductive_system_phenotype1.15321649
56MP0004215_abnormal_myocardial_fiber1.09851368
57MP0008058_abnormal_DNA_repair1.09238055
58MP0000647_abnormal_sebaceous_gland1.08617028
59MP0004147_increased_porphyrin_level1.06393366
60MP0002160_abnormal_reproductive_system1.01817323
61MP0001529_abnormal_vocalization1.01606344
62MP0002557_abnormal_social/conspecific_i0.99741741
63MP0005171_absent_coat_pigmentation0.99356812
64MP0002234_abnormal_pharynx_morphology0.99140102
65MP0004924_abnormal_behavior0.96694754
66MP0005386_behavior/neurological_phenoty0.96694754
67MP0000230_abnormal_systemic_arterial0.96527357
68MP0004484_altered_response_of0.95206998
69MP0001502_abnormal_circadian_rhythm0.95085392
70MP0005195_abnormal_posterior_eye0.93342783
71MP0003252_abnormal_bile_duct0.92260658
72MP0001919_abnormal_reproductive_system0.92132629
73MP0002067_abnormal_sensory_capabilities0.90568522
74MP0004145_abnormal_muscle_electrophysio0.89537681
75MP0005167_abnormal_blood-brain_barrier0.89515491
76MP0002572_abnormal_emotion/affect_behav0.88971722
77MP0001764_abnormal_homeostasis0.87664333
78MP0002751_abnormal_autonomic_nervous0.86344307
79MP0002163_abnormal_gland_morphology0.84628891
80MP0008775_abnormal_heart_ventricle0.83982778
81MP0003890_abnormal_embryonic-extraembry0.81932167
82MP0005410_abnormal_fertilization0.80565522
83MP0005332_abnormal_amino_acid0.80117450
84MP0005391_vision/eye_phenotype0.78645278
85MP0008057_abnormal_DNA_replication0.78150014
86MP0002064_seizures0.78062601
87MP0005408_hypopigmentation0.76045807
88MP0005379_endocrine/exocrine_gland_phen0.76006340
89MP0002653_abnormal_ependyma_morphology0.75718002
90MP0001970_abnormal_pain_threshold0.74805695
91MP0004085_abnormal_heartbeat0.74661400
92MP0003786_premature_aging0.74355664
93MP0003045_fibrosis0.73684099
94MP0000538_abnormal_urinary_bladder0.73209341
95MP0004742_abnormal_vestibular_system0.73208855
96MP0000778_abnormal_nervous_system0.73169884
97MP0002229_neurodegeneration0.73136894
98MP0003698_abnormal_male_reproductive0.72376956
99MP0005266_abnormal_metabolism0.71445879
100MP0003718_maternal_effect0.71016607

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.62432796
2Pancreatic fibrosis (HP:0100732)4.31624227
3True hermaphroditism (HP:0010459)4.29857047
4Abnormality of midbrain morphology (HP:0002418)3.92395642
5Molar tooth sign on MRI (HP:0002419)3.92395642
6Congenital stationary night blindness (HP:0007642)3.87733843
7Nephronophthisis (HP:0000090)3.55147215
8Chronic hepatic failure (HP:0100626)3.49073339
9Abnormality of the renal cortex (HP:0011035)3.27957576
10Type II lissencephaly (HP:0007260)3.23935638
11Abnormality of the renal medulla (HP:0100957)3.19194487
12Medial flaring of the eyebrow (HP:0010747)3.09048071
13Hyperventilation (HP:0002883)2.85217047
14Cystic liver disease (HP:0006706)2.82590814
15Tubular atrophy (HP:0000092)2.70632033
16Gaze-evoked nystagmus (HP:0000640)2.68387013
17Decreased central vision (HP:0007663)2.65206864
18Attenuation of retinal blood vessels (HP:0007843)2.59103481
19Aplasia/Hypoplasia of the tibia (HP:0005772)2.55134669
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.53557888
21Abnormal drinking behavior (HP:0030082)2.52925049
22Polydipsia (HP:0001959)2.52925049
23Abnormal biliary tract physiology (HP:0012439)2.52492394
24Bile duct proliferation (HP:0001408)2.52492394
25Renal cortical cysts (HP:0000803)2.52237225
26Methylmalonic acidemia (HP:0002912)2.44181035
27Abolished electroretinogram (ERG) (HP:0000550)2.43335609
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43301547
29Abnormality of alanine metabolism (HP:0010916)2.43301547
30Hyperalaninemia (HP:0003348)2.43301547
31Gait imbalance (HP:0002141)2.39242686
32Congenital primary aphakia (HP:0007707)2.36673053
33Cerebellar dysplasia (HP:0007033)2.35636964
34Sclerocornea (HP:0000647)2.29872854
35Anencephaly (HP:0002323)2.28420558
36Progressive cerebellar ataxia (HP:0002073)2.24353238
37Hypothermia (HP:0002045)2.22620402
38Lissencephaly (HP:0001339)2.22016351
39Acute necrotizing encephalopathy (HP:0006965)2.19205768
40Male pseudohermaphroditism (HP:0000037)2.18884961
41Large for gestational age (HP:0001520)2.18374767
42Postaxial foot polydactyly (HP:0001830)2.17489593
43Congenital hepatic fibrosis (HP:0002612)2.17441914
44Nephrogenic diabetes insipidus (HP:0009806)2.13736025
45Stomach cancer (HP:0012126)2.13536022
46Progressive macrocephaly (HP:0004481)2.12465121
47Pendular nystagmus (HP:0012043)2.11169105
48Acute encephalopathy (HP:0006846)2.09415226
49Broad-based gait (HP:0002136)2.09378658
50Febrile seizures (HP:0002373)2.08648517
51Furrowed tongue (HP:0000221)2.08475421
52Fair hair (HP:0002286)2.06442193
53Abnormal rod and cone electroretinograms (HP:0008323)2.06270015
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05490761
55Inability to walk (HP:0002540)2.04734085
56Increased CSF lactate (HP:0002490)2.04505325
57Increased corneal curvature (HP:0100692)2.03719033
58Keratoconus (HP:0000563)2.03719033
59Absent speech (HP:0001344)2.02655258
60Methylmalonic aciduria (HP:0012120)2.02071493
61Polyuria (HP:0000103)2.01752628
62Short tibia (HP:0005736)2.01716072
63Abnormality of the pons (HP:0007361)2.00995494
64Absent/shortened dynein arms (HP:0200106)2.00711355
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.00711355
66Genetic anticipation (HP:0003743)1.99399034
67Decreased circulating renin level (HP:0003351)1.98150087
68Mitochondrial inheritance (HP:0001427)1.97347299
69Chorioretinal atrophy (HP:0000533)1.96732059
70Genital tract atresia (HP:0001827)1.94927090
71Optic nerve hypoplasia (HP:0000609)1.94420674
72Pachygyria (HP:0001302)1.91826289
73Progressive inability to walk (HP:0002505)1.89950839
74Tubulointerstitial nephritis (HP:0001970)1.87759692
75Small hand (HP:0200055)1.86104187
76Abnormal respiratory epithelium morphology (HP:0012253)1.84461448
77Abnormal respiratory motile cilium morphology (HP:0005938)1.84461448
78Postaxial hand polydactyly (HP:0001162)1.84334594
79Thyroiditis (HP:0100646)1.84124814
80Hyperglycinemia (HP:0002154)1.83904198
81Abnormality of the labia minora (HP:0012880)1.83897217
82Congenital, generalized hypertrichosis (HP:0004540)1.83387961
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.82538420
84Hypoplasia of the fovea (HP:0007750)1.82538420
85Vaginal atresia (HP:0000148)1.82042099
86Occipital encephalocele (HP:0002085)1.81667144
87Widely spaced teeth (HP:0000687)1.81553376
88Colon cancer (HP:0003003)1.81365164
89Abnormal ciliary motility (HP:0012262)1.80378723
90Abnormality of macular pigmentation (HP:0008002)1.79886315
91Ketosis (HP:0001946)1.77922936
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77688191
93Concave nail (HP:0001598)1.77424521
94Polyphagia (HP:0002591)1.76613305
95Optic disc pallor (HP:0000543)1.76486527
96Congenital sensorineural hearing impairment (HP:0008527)1.76061943
97Oligodactyly (hands) (HP:0001180)1.74053078
98Poor coordination (HP:0002370)1.73250683
99Hypoplasia of the pons (HP:0012110)1.72576948
100Intestinal atresia (HP:0011100)1.72427267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.78864926
2BMPR1B3.55483424
3PINK12.75723008
4NUAK12.64879323
5WNK32.55870694
6ACVR1B2.50653821
7MAP4K22.48970339
8ADRBK22.27767028
9GRK12.19775991
10TAOK31.97986972
11TRIM281.93259509
12INSRR1.87136888
13ZAK1.85623609
14CASK1.76904492
15MAPK131.60683395
16OXSR11.58950426
17PAK31.56573005
18MAP3K41.54498024
19AKT31.41664482
20MKNK21.41080593
21TNIK1.40618250
22STK391.40431266
23BCR1.36714856
24WNK41.35252831
25PLK21.33577296
26BRSK21.32730635
27ERBB31.28336195
28MST41.22664673
29STK38L1.15087427
30EIF2AK31.14408106
31TLK11.06709474
32TGFBR11.05156256
33ADRBK11.02688499
34CSNK1G20.96961094
35TXK0.96500823
36PRKCE0.95878354
37DAPK20.95093349
38PTK2B0.94698725
39NLK0.93186372
40DYRK20.92605283
41WEE10.90824334
42OBSCN0.90525206
43PNCK0.90417443
44IRAK10.90256997
45CSNK1A1L0.88591634
46PIK3CG0.86683726
47TIE10.86400040
48CSNK1G10.83788302
49MAP2K70.83226688
50FER0.79431300
51PDK20.78687498
52CSNK1G30.78337632
53CAMKK20.76423656
54FGFR20.73738763
55MUSK0.73150486
56EPHA30.72517950
57PLK30.70961037
58SGK20.70439584
59PIK3CA0.70397916
60MKNK10.67546730
61PRKCG0.65479777
62MARK30.63355437
63STK30.62799967
64VRK10.61110954
65LATS10.55362280
66TEC0.53026930
67MAPK150.49611938
68RPS6KA50.49192863
69CAMK2A0.49189371
70PHKG20.48393275
71PHKG10.48393275
72GRK70.48065576
73GRK50.47695899
74DYRK1A0.46979741
75IKBKB0.46966420
76NTRK30.46056944
77BMPR20.45344438
78BCKDK0.45270641
79PLK40.45141426
80MARK10.44761321
81PRKAA20.43964513
82TRPM70.43108784
83SGK2230.42889718
84SGK4940.42889718
85MAPKAPK30.41765803
86PRKCQ0.40825630
87CSNK1A10.40441626
88PRKACA0.40106564
89FLT30.39561213
90DYRK30.39147816
91ERBB20.38020223
92CDK80.36449101
93PRKG10.35971858
94TNK20.35859999
95CAMK10.35596762
96PKN10.35095956
97STK110.34301791
98NTRK20.31442174
99CSNK1D0.31288430
100CHUK0.30618498

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04476698
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68520982
3Phototransduction_Homo sapiens_hsa047442.57388114
4Butanoate metabolism_Homo sapiens_hsa006502.56063599
5Linoleic acid metabolism_Homo sapiens_hsa005912.49780760
6Nitrogen metabolism_Homo sapiens_hsa009102.43842580
7Protein export_Homo sapiens_hsa030602.40905385
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38061466
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09819212
10Propanoate metabolism_Homo sapiens_hsa006402.00741638
11Oxidative phosphorylation_Homo sapiens_hsa001901.86481448
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82577909
13Nicotine addiction_Homo sapiens_hsa050331.82016776
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79386658
15Tryptophan metabolism_Homo sapiens_hsa003801.76840677
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76757650
17Selenocompound metabolism_Homo sapiens_hsa004501.75620605
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75491397
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.72384065
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71283600
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.69518170
22Caffeine metabolism_Homo sapiens_hsa002321.65930308
23Fanconi anemia pathway_Homo sapiens_hsa034601.65483096
24Basal transcription factors_Homo sapiens_hsa030221.64262489
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58258482
26Homologous recombination_Homo sapiens_hsa034401.58081020
27Ether lipid metabolism_Homo sapiens_hsa005651.54796470
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48512646
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47864439
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47149269
31Parkinsons disease_Homo sapiens_hsa050121.46553160
32Peroxisome_Homo sapiens_hsa041461.44458639
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.41263073
34RNA polymerase_Homo sapiens_hsa030201.34119740
35Chemical carcinogenesis_Homo sapiens_hsa052041.32191716
36ABC transporters_Homo sapiens_hsa020101.30976089
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29893245
38Taste transduction_Homo sapiens_hsa047421.26432949
39RNA degradation_Homo sapiens_hsa030181.26235931
40Retinol metabolism_Homo sapiens_hsa008301.25983899
41Regulation of autophagy_Homo sapiens_hsa041401.22026497
42Circadian rhythm_Homo sapiens_hsa047101.21715162
43Olfactory transduction_Homo sapiens_hsa047401.17434002
44Morphine addiction_Homo sapiens_hsa050321.13446522
45Arachidonic acid metabolism_Homo sapiens_hsa005901.07226949
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06522768
47Serotonergic synapse_Homo sapiens_hsa047260.99362416
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97525356
49GABAergic synapse_Homo sapiens_hsa047270.97459452
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96080646
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95777332
52Huntingtons disease_Homo sapiens_hsa050160.90839517
53Collecting duct acid secretion_Homo sapiens_hsa049660.87078666
54Steroid biosynthesis_Homo sapiens_hsa001000.84230248
55Alzheimers disease_Homo sapiens_hsa050100.83253366
56Dorso-ventral axis formation_Homo sapiens_hsa043200.81557790
57beta-Alanine metabolism_Homo sapiens_hsa004100.81300720
58Non-homologous end-joining_Homo sapiens_hsa034500.79783529
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77467725
60Circadian entrainment_Homo sapiens_hsa047130.76983020
61Insulin secretion_Homo sapiens_hsa049110.74804929
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72418548
63Sulfur metabolism_Homo sapiens_hsa009200.71577314
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70728558
65Fat digestion and absorption_Homo sapiens_hsa049750.70469340
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69373586
67Mineral absorption_Homo sapiens_hsa049780.69128368
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67962737
69Fatty acid degradation_Homo sapiens_hsa000710.67638117
70One carbon pool by folate_Homo sapiens_hsa006700.67616748
71Ovarian steroidogenesis_Homo sapiens_hsa049130.65491963
72Glycerolipid metabolism_Homo sapiens_hsa005610.64425454
73Glutamatergic synapse_Homo sapiens_hsa047240.63312039
74Metabolic pathways_Homo sapiens_hsa011000.61078948
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.59336497
76Calcium signaling pathway_Homo sapiens_hsa040200.59321988
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57713654
78Cardiac muscle contraction_Homo sapiens_hsa042600.57465763
79Fatty acid biosynthesis_Homo sapiens_hsa000610.57219182
80Purine metabolism_Homo sapiens_hsa002300.53743762
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53189538
82Salivary secretion_Homo sapiens_hsa049700.53178784
83Proteasome_Homo sapiens_hsa030500.51865243
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49259020
85Histidine metabolism_Homo sapiens_hsa003400.46520174
86Dopaminergic synapse_Homo sapiens_hsa047280.42970368
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.42583244
88Hedgehog signaling pathway_Homo sapiens_hsa043400.41490529
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.40941672
90Fatty acid metabolism_Homo sapiens_hsa012120.37846948
91Vitamin digestion and absorption_Homo sapiens_hsa049770.36905224
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36683641
93Cocaine addiction_Homo sapiens_hsa050300.34419630
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31581951
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29622482
96TGF-beta signaling pathway_Homo sapiens_hsa043500.28117321
97Asthma_Homo sapiens_hsa053100.27228188
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27170632
99cAMP signaling pathway_Homo sapiens_hsa040240.26074651
100Oxytocin signaling pathway_Homo sapiens_hsa049210.25743650

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