ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.83696739
2	protein K11-linked deubiquitination (GO:0035871)	3.94286662
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.86676881
4	fucose catabolic process (GO:0019317)	3.77630299
5	L-fucose metabolic process (GO:0042354)	3.77630299
6	L-fucose catabolic process (GO:0042355)	3.77630299
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.72379686
8	indolalkylamine metabolic process (GO:0006586)	3.71935433
9	platelet dense granule organization (GO:0060155)	3.67268171
10	indole-containing compound catabolic process (GO:0042436)	3.60145971
11	indolalkylamine catabolic process (GO:0046218)	3.60145971
12	tryptophan catabolic process (GO:0006569)	3.60145971
13	cellular ketone body metabolic process (GO:0046950)	3.58868525
14	epithelial cilium movement (GO:0003351)	3.46559462
15	neural tube formation (GO:0001841)	3.46099119
16	ketone body metabolic process (GO:1902224)	3.45103087
17	response to pheromone (GO:0019236)	3.41708329
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.40280899
19	DNA deamination (GO:0045006)	3.38063387
20	kynurenine metabolic process (GO:0070189)	3.30286253
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.28065209
22	cilium morphogenesis (GO:0060271)	3.24440296
23	tryptophan metabolic process (GO:0006568)	3.20754702
24	detection of light stimulus involved in visual perception (GO:0050908)	3.17795872
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.17795872
26	piRNA metabolic process (GO:0034587)	3.16927023
27	axoneme assembly (GO:0035082)	3.13636643
28	dopamine transport (GO:0015872)	3.00953673
29	respiratory chain complex IV assembly (GO:0008535)	3.00667472
30	regulation of cilium movement (GO:0003352)	2.97055348
31	somite development (GO:0061053)	2.94350791
32	cilium movement (GO:0003341)	2.90726696
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90692049
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90692049
35	NADH dehydrogenase complex assembly (GO:0010257)	2.90692049
36	protein complex biogenesis (GO:0070271)	2.89062904
37	establishment of protein localization to Golgi (GO:0072600)	2.88824906
38	regulation of meiosis I (GO:0060631)	2.88562813
39	negative regulation of mast cell activation (GO:0033004)	2.84546219
40	regulation of hexokinase activity (GO:1903299)	2.82000634
41	regulation of glucokinase activity (GO:0033131)	2.82000634
42	prenylation (GO:0097354)	2.81739131
43	protein prenylation (GO:0018342)	2.81739131
44	regulation of translation, ncRNA-mediated (GO:0045974)	2.80859144
45	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.80859144
46	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.80859144
47	amine catabolic process (GO:0009310)	2.80156119
48	cellular biogenic amine catabolic process (GO:0042402)	2.80156119
49	protein polyglutamylation (GO:0018095)	2.76835220
50	photoreceptor cell maintenance (GO:0045494)	2.74902799
51	cilium organization (GO:0044782)	2.70181989
52	protein localization to cilium (GO:0061512)	2.68956273
53	pyrimidine nucleobase catabolic process (GO:0006208)	2.68928701
54	protein-cofactor linkage (GO:0018065)	2.68682664
55	reflex (GO:0060004)	2.68331709
56	regulation of neurotransmitter uptake (GO:0051580)	2.67670634
57	indole-containing compound metabolic process (GO:0042430)	2.66790186
58	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.64898212
59	mannosylation (GO:0097502)	2.64433297
60	cilium assembly (GO:0042384)	2.62534007
61	behavioral response to ethanol (GO:0048149)	2.62359130
62	intraciliary transport (GO:0042073)	2.61803991
63	DNA methylation involved in gamete generation (GO:0043046)	2.60890204
64	anterograde synaptic vesicle transport (GO:0048490)	2.59622455
65	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58585972
66	cytochrome complex assembly (GO:0017004)	2.57901456
67	photoreceptor cell development (GO:0042461)	2.57372831
68	regulation of action potential (GO:0098900)	2.56939004
69	cilium or flagellum-dependent cell motility (GO:0001539)	2.56825874
70	S-adenosylmethionine metabolic process (GO:0046500)	2.55034108
71	GPI anchor metabolic process (GO:0006505)	2.51964985
72	gamma-aminobutyric acid transport (GO:0015812)	2.50801426
73	nonmotile primary cilium assembly (GO:0035058)	2.50751046
74	multicellular organism reproduction (GO:0032504)	2.49055230
75	kidney morphogenesis (GO:0060993)	2.47240764
76	adaptation of signaling pathway (GO:0023058)	2.46607097
77	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.44580768
78	rRNA catabolic process (GO:0016075)	2.44497062
79	sulfation (GO:0051923)	2.43755731
80	protein targeting to Golgi (GO:0000042)	2.43736937
81	retinal cone cell development (GO:0046549)	2.43643438
82	protein K63-linked deubiquitination (GO:0070536)	2.43512322
83	reciprocal DNA recombination (GO:0035825)	2.43266302
84	reciprocal meiotic recombination (GO:0007131)	2.43266302
85	recombinational repair (GO:0000725)	2.43080969
86	replication fork processing (GO:0031297)	2.42605310
87	double-strand break repair via homologous recombination (GO:0000724)	2.41707790
88	oxidative demethylation (GO:0070989)	2.41297537
89	drug catabolic process (GO:0042737)	2.41287517
90	cornea development in camera-type eye (GO:0061303)	2.41186652
91	embryonic epithelial tube formation (GO:0001838)	2.40057530
92	protein localization to Golgi apparatus (GO:0034067)	2.38747430
93	nucleobase catabolic process (GO:0046113)	2.35614240
94	regulation of hippo signaling (GO:0035330)	2.35405410
95	signal peptide processing (GO:0006465)	2.35117351
96	heme transport (GO:0015886)	2.33916280
97	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.33879269
98	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.33769012
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.33769012
100	exogenous drug catabolic process (GO:0042738)	2.32562068

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.41591804
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.24056049
3	VDR_22108803_ChIP-Seq_LS180_Human	3.05277953
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.02214112
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75057234
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67773417
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.49995583
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.41890928
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.38937470
10	FUS_26573619_Chip-Seq_HEK293_Human	2.28044090
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22600482
12	P300_19829295_ChIP-Seq_ESCs_Human	2.20732555
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.14626605
14	EWS_26573619_Chip-Seq_HEK293_Human	2.11444902
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.07065845
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.06633684
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06266835
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.01744823
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.94619205
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87234524
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.83870309
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79595640
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.73576137
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.73576137
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72030381
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.71564843
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.69663401
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68146919
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67914444
30	* STAT3_23295773_ChIP-Seq_U87_Human	1.63648074
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.57698014
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.57045233
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.55606352
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55049245
35	AR_25329375_ChIP-Seq_VCAP_Human	1.51104998
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50366183
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49717705
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48788411
39	TCF4_23295773_ChIP-Seq_U87_Human	1.48758833
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48367255
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48118105
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46957547
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46567038
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44056862
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43949502
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43511476
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41507518
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41365120
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41172892
50	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40862693
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40563754
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.38026092
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37923220
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37923220
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36659553
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.35826537
57	AR_21572438_ChIP-Seq_LNCaP_Human	1.35387264
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35002054
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34049461
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34049461
61	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.32723523
62	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.31246419
63	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30616329
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28679993
65	CDX2_22108803_ChIP-Seq_LS180_Human	1.28455670
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27734167
67	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27428662
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26676008
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26459209
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25715615
71	ELK1_19687146_ChIP-ChIP_HELA_Human	1.24950638
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21619658
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21417947
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20728471
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19610772
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16446810
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16024493
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15616119
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12881060
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12881060
81	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10366568
82	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09202581
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08786409
84	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.08298063
85	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07256852
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06727988
87	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.06532207
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06408508
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05832867
90	MYC_18940864_ChIP-ChIP_HL60_Human	1.05786839
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04297276
92	TP53_16413492_ChIP-PET_HCT116_Human	1.03822519
93	AR_20517297_ChIP-Seq_VCAP_Human	1.02783230
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02566678
95	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.02058812
96	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.01775807
97	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01621894
98	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01162331
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01133434
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00154387

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.88229567
2	MP0003195_calcinosis	3.43444178
3	MP0008877_abnormal_DNA_methylation	3.39952132
4	MP0000372_irregular_coat_pigmentation	2.87665125
5	MP0003646_muscle_fatigue	2.82867195
6	MP0003787_abnormal_imprinting	2.60787747
7	MP0002102_abnormal_ear_morphology	2.59009238
8	MP0005551_abnormal_eye_electrophysiolog	2.44861725
9	MP0003136_yellow_coat_color	2.33278650
10	MP0002837_dystrophic_cardiac_calcinosis	2.12576942
11	MP0005646_abnormal_pituitary_gland	2.11568156
12	MP0000427_abnormal_hair_cycle	2.04220212
13	MP0005253_abnormal_eye_physiology	2.03918498
14	MP0001984_abnormal_olfaction	1.92651396
15	MP0006072_abnormal_retinal_apoptosis	1.90437830
16	MP0004142_abnormal_muscle_tone	1.89403283
17	MP0002876_abnormal_thyroid_physiology	1.88535950
18	MP0005174_abnormal_tail_pigmentation	1.85010710
19	MP0002638_abnormal_pupillary_reflex	1.79784181
20	MP0006276_abnormal_autonomic_nervous	1.79115004
21	MP0003011_delayed_dark_adaptation	1.73099748
22	MP0006292_abnormal_olfactory_placode	1.70336327
23	MP0009046_muscle_twitch	1.68886328
24	MP0008995_early_reproductive_senescence	1.65325221
25	MP0005084_abnormal_gallbladder_morpholo	1.60958126
26	MP0005645_abnormal_hypothalamus_physiol	1.60371488
27	MP0008875_abnormal_xenobiotic_pharmacok	1.56288437
28	MP0001501_abnormal_sleep_pattern	1.54968795
29	MP0003880_abnormal_central_pattern	1.51910720
30	MP0005075_abnormal_melanosome_morpholog	1.49519739
31	MP0001485_abnormal_pinna_reflex	1.48864532
32	MP0002928_abnormal_bile_duct	1.47486432
33	MP0001968_abnormal_touch/_nociception	1.47163095
34	MP0008872_abnormal_physiological_respon	1.44941332
35	MP0002938_white_spotting	1.43296181
36	MP0009745_abnormal_behavioral_response	1.42550697
37	MP0003121_genomic_imprinting	1.41544477
38	MP0001486_abnormal_startle_reflex	1.40779430
39	MP0004043_abnormal_pH_regulation	1.38463021
40	MP0000383_abnormal_hair_follicle	1.36329160
41	MP0002138_abnormal_hepatobiliary_system	1.36073516
42	MP0004133_heterotaxia	1.33994819
43	MP0000631_abnormal_neuroendocrine_gland	1.33849495
44	MP0005187_abnormal_penis_morphology	1.31508011
45	MP0002095_abnormal_skin_pigmentation	1.31481481
46	MP0001986_abnormal_taste_sensitivity	1.31311564
47	MP0010386_abnormal_urinary_bladder	1.31031376
48	MP0002272_abnormal_nervous_system	1.29895260
49	MP0004885_abnormal_endolymph	1.29671043
50	MP0003950_abnormal_plasma_membrane	1.28031914
51	MP0003122_maternal_imprinting	1.25710790
52	MP0000015_abnormal_ear_pigmentation	1.24137436
53	MP0002736_abnormal_nociception_after	1.22937633
54	MP0001324_abnormal_eye_pigmentation	1.17818823
55	MP0005389_reproductive_system_phenotype	1.15321649
56	MP0004215_abnormal_myocardial_fiber	1.09851368
57	MP0008058_abnormal_DNA_repair	1.09238055
58	MP0000647_abnormal_sebaceous_gland	1.08617028
59	MP0004147_increased_porphyrin_level	1.06393366
60	MP0002160_abnormal_reproductive_system	1.01817323
61	MP0001529_abnormal_vocalization	1.01606344
62	MP0002557_abnormal_social/conspecific_i	0.99741741
63	MP0005171_absent_coat_pigmentation	0.99356812
64	MP0002234_abnormal_pharynx_morphology	0.99140102
65	MP0005386_behavior/neurological_phenoty	0.96694754
66	MP0004924_abnormal_behavior	0.96694754
67	MP0000230_abnormal_systemic_arterial	0.96527357
68	MP0004484_altered_response_of	0.95206998
69	MP0001502_abnormal_circadian_rhythm	0.95085392
70	MP0005195_abnormal_posterior_eye	0.93342783
71	MP0003252_abnormal_bile_duct	0.92260658
72	MP0001919_abnormal_reproductive_system	0.92132629
73	MP0002067_abnormal_sensory_capabilities	0.90568522
74	MP0004145_abnormal_muscle_electrophysio	0.89537681
75	MP0005167_abnormal_blood-brain_barrier	0.89515491
76	MP0002572_abnormal_emotion/affect_behav	0.88971722
77	MP0001764_abnormal_homeostasis	0.87664333
78	MP0002751_abnormal_autonomic_nervous	0.86344307
79	MP0002163_abnormal_gland_morphology	0.84628891
80	MP0008775_abnormal_heart_ventricle	0.83982778
81	MP0003890_abnormal_embryonic-extraembry	0.81932167
82	MP0005410_abnormal_fertilization	0.80565522
83	MP0005332_abnormal_amino_acid	0.80117450
84	MP0005391_vision/eye_phenotype	0.78645278
85	MP0008057_abnormal_DNA_replication	0.78150014
86	MP0002064_seizures	0.78062601
87	MP0005408_hypopigmentation	0.76045807
88	MP0005379_endocrine/exocrine_gland_phen	0.76006340
89	MP0002653_abnormal_ependyma_morphology	0.75718002
90	MP0001970_abnormal_pain_threshold	0.74805695
91	MP0004085_abnormal_heartbeat	0.74661400
92	MP0003786_premature_aging	0.74355664
93	MP0003045_fibrosis	0.73684099
94	MP0000538_abnormal_urinary_bladder	0.73209341
95	MP0004742_abnormal_vestibular_system	0.73208855
96	MP0000778_abnormal_nervous_system	0.73169884
97	MP0002229_neurodegeneration	0.73136894
98	MP0003698_abnormal_male_reproductive	0.72376956
99	MP0005266_abnormal_metabolism	0.71445879
100	MP0003718_maternal_effect	0.71016607

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.62432796
2	Pancreatic fibrosis (HP:0100732)	4.31624227
3	True hermaphroditism (HP:0010459)	4.29857047
4	Molar tooth sign on MRI (HP:0002419)	3.92395642
5	Abnormality of midbrain morphology (HP:0002418)	3.92395642
6	Congenital stationary night blindness (HP:0007642)	3.87733843
7	Nephronophthisis (HP:0000090)	3.55147215
8	Chronic hepatic failure (HP:0100626)	3.49073339
9	Abnormality of the renal cortex (HP:0011035)	3.27957576
10	Type II lissencephaly (HP:0007260)	3.23935638
11	Abnormality of the renal medulla (HP:0100957)	3.19194487
12	Medial flaring of the eyebrow (HP:0010747)	3.09048071
13	Hyperventilation (HP:0002883)	2.85217047
14	Cystic liver disease (HP:0006706)	2.82590814
15	Tubular atrophy (HP:0000092)	2.70632033
16	Gaze-evoked nystagmus (HP:0000640)	2.68387013
17	Decreased central vision (HP:0007663)	2.65206864
18	Attenuation of retinal blood vessels (HP:0007843)	2.59103481
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.55134669
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.53557888
21	Polydipsia (HP:0001959)	2.52925049
22	Abnormal drinking behavior (HP:0030082)	2.52925049
23	Bile duct proliferation (HP:0001408)	2.52492394
24	Abnormal biliary tract physiology (HP:0012439)	2.52492394
25	Renal cortical cysts (HP:0000803)	2.52237225
26	Methylmalonic acidemia (HP:0002912)	2.44181035
27	Abolished electroretinogram (ERG) (HP:0000550)	2.43335609
28	Hyperalaninemia (HP:0003348)	2.43301547
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.43301547
30	Abnormality of alanine metabolism (HP:0010916)	2.43301547
31	Gait imbalance (HP:0002141)	2.39242686
32	Congenital primary aphakia (HP:0007707)	2.36673053
33	Cerebellar dysplasia (HP:0007033)	2.35636964
34	Sclerocornea (HP:0000647)	2.29872854
35	Anencephaly (HP:0002323)	2.28420558
36	Progressive cerebellar ataxia (HP:0002073)	2.24353238
37	Hypothermia (HP:0002045)	2.22620402
38	Lissencephaly (HP:0001339)	2.22016351
39	Acute necrotizing encephalopathy (HP:0006965)	2.19205768
40	Male pseudohermaphroditism (HP:0000037)	2.18884961
41	Large for gestational age (HP:0001520)	2.18374767
42	Postaxial foot polydactyly (HP:0001830)	2.17489593
43	Congenital hepatic fibrosis (HP:0002612)	2.17441914
44	Nephrogenic diabetes insipidus (HP:0009806)	2.13736025
45	Stomach cancer (HP:0012126)	2.13536022
46	Progressive macrocephaly (HP:0004481)	2.12465121
47	Pendular nystagmus (HP:0012043)	2.11169105
48	Acute encephalopathy (HP:0006846)	2.09415226
49	Broad-based gait (HP:0002136)	2.09378658
50	Febrile seizures (HP:0002373)	2.08648517
51	Furrowed tongue (HP:0000221)	2.08475421
52	Fair hair (HP:0002286)	2.06442193
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.06270015
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.05490761
55	Inability to walk (HP:0002540)	2.04734085
56	Increased CSF lactate (HP:0002490)	2.04505325
57	Keratoconus (HP:0000563)	2.03719033
58	Increased corneal curvature (HP:0100692)	2.03719033
59	Absent speech (HP:0001344)	2.02655258
60	Methylmalonic aciduria (HP:0012120)	2.02071493
61	Polyuria (HP:0000103)	2.01752628
62	Short tibia (HP:0005736)	2.01716072
63	Abnormality of the pons (HP:0007361)	2.00995494
64	Absent/shortened dynein arms (HP:0200106)	2.00711355
65	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00711355
66	Genetic anticipation (HP:0003743)	1.99399034
67	Decreased circulating renin level (HP:0003351)	1.98150087
68	Mitochondrial inheritance (HP:0001427)	1.97347299
69	Chorioretinal atrophy (HP:0000533)	1.96732059
70	Genital tract atresia (HP:0001827)	1.94927090
71	Optic nerve hypoplasia (HP:0000609)	1.94420674
72	Pachygyria (HP:0001302)	1.91826289
73	Progressive inability to walk (HP:0002505)	1.89950839
74	Tubulointerstitial nephritis (HP:0001970)	1.87759692
75	Small hand (HP:0200055)	1.86104187
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.84461448
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84461448
78	Postaxial hand polydactyly (HP:0001162)	1.84334594
79	Thyroiditis (HP:0100646)	1.84124814
80	Hyperglycinemia (HP:0002154)	1.83904198
81	Abnormality of the labia minora (HP:0012880)	1.83897217
82	Congenital, generalized hypertrichosis (HP:0004540)	1.83387961
83	Hypoplasia of the fovea (HP:0007750)	1.82538420
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82538420
85	Vaginal atresia (HP:0000148)	1.82042099
86	Occipital encephalocele (HP:0002085)	1.81667144
87	Widely spaced teeth (HP:0000687)	1.81553376
88	Colon cancer (HP:0003003)	1.81365164
89	Abnormal ciliary motility (HP:0012262)	1.80378723
90	Abnormality of macular pigmentation (HP:0008002)	1.79886315
91	Ketosis (HP:0001946)	1.77922936
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77688191
93	Concave nail (HP:0001598)	1.77424521
94	Polyphagia (HP:0002591)	1.76613305
95	Optic disc pallor (HP:0000543)	1.76486527
96	Congenital sensorineural hearing impairment (HP:0008527)	1.76061943
97	Oligodactyly (hands) (HP:0001180)	1.74053078
98	Poor coordination (HP:0002370)	1.73250683
99	Hypoplasia of the pons (HP:0012110)	1.72576948
100	Intestinal atresia (HP:0011100)	1.72427267

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.78864926
2	BMPR1B	3.55483424
3	PINK1	2.75723008
4	NUAK1	2.64879323
5	WNK3	2.55870694
6	ACVR1B	2.50653821
7	MAP4K2	2.48970339
8	ADRBK2	2.27767028
9	GRK1	2.19775991
10	TAOK3	1.97986972
11	TRIM28	1.93259509
12	INSRR	1.87136888
13	ZAK	1.85623609
14	CASK	1.76904492
15	MAPK13	1.60683395
16	OXSR1	1.58950426
17	PAK3	1.56573005
18	MAP3K4	1.54498024
19	AKT3	1.41664482
20	MKNK2	1.41080593
21	TNIK	1.40618250
22	STK39	1.40431266
23	BCR	1.36714856
24	WNK4	1.35252831
25	PLK2	1.33577296
26	BRSK2	1.32730635
27	ERBB3	1.28336195
28	MST4	1.22664673
29	STK38L	1.15087427
30	EIF2AK3	1.14408106
31	TLK1	1.06709474
32	TGFBR1	1.05156256
33	ADRBK1	1.02688499
34	CSNK1G2	0.96961094
35	TXK	0.96500823
36	PRKCE	0.95878354
37	DAPK2	0.95093349
38	PTK2B	0.94698725
39	NLK	0.93186372
40	DYRK2	0.92605283
41	WEE1	0.90824334
42	OBSCN	0.90525206
43	PNCK	0.90417443
44	IRAK1	0.90256997
45	CSNK1A1L	0.88591634
46	PIK3CG	0.86683726
47	TIE1	0.86400040
48	CSNK1G1	0.83788302
49	MAP2K7	0.83226688
50	FER	0.79431300
51	PDK2	0.78687498
52	CSNK1G3	0.78337632
53	CAMKK2	0.76423656
54	FGFR2	0.73738763
55	MUSK	0.73150486
56	EPHA3	0.72517950
57	PLK3	0.70961037
58	SGK2	0.70439584
59	PIK3CA	0.70397916
60	MKNK1	0.67546730
61	PRKCG	0.65479777
62	MARK3	0.63355437
63	STK3	0.62799967
64	VRK1	0.61110954
65	LATS1	0.55362280
66	TEC	0.53026930
67	MAPK15	0.49611938
68	RPS6KA5	0.49192863
69	CAMK2A	0.49189371
70	PHKG1	0.48393275
71	PHKG2	0.48393275
72	GRK7	0.48065576
73	GRK5	0.47695899
74	DYRK1A	0.46979741
75	IKBKB	0.46966420
76	NTRK3	0.46056944
77	BMPR2	0.45344438
78	BCKDK	0.45270641
79	PLK4	0.45141426
80	MARK1	0.44761321
81	PRKAA2	0.43964513
82	TRPM7	0.43108784
83	SGK223	0.42889718
84	SGK494	0.42889718
85	MAPKAPK3	0.41765803
86	PRKCQ	0.40825630
87	CSNK1A1	0.40441626
88	PRKACA	0.40106564
89	FLT3	0.39561213
90	DYRK3	0.39147816
91	ERBB2	0.38020223
92	CDK8	0.36449101
93	PRKG1	0.35971858
94	TNK2	0.35859999
95	CAMK1	0.35596762
96	PKN1	0.35095956
97	STK11	0.34301791
98	NTRK2	0.31442174
99	CSNK1D	0.31288430
100	CHUK	0.30618498

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.04476698
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.68520982
3	Phototransduction_Homo sapiens_hsa04744	2.57388114
4	Butanoate metabolism_Homo sapiens_hsa00650	2.56063599
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.49780760
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.43842580
7	Protein export_Homo sapiens_hsa03060	2.40905385
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38061466
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.09819212
10	Propanoate metabolism_Homo sapiens_hsa00640	2.00741638
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.86481448
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.82577909
13	Nicotine addiction_Homo sapiens_hsa05033	1.82016776
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79386658
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.76840677
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.76757650
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.75620605
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75491397
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72384065
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.71283600
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.69518170
22	Caffeine metabolism_Homo sapiens_hsa00232	1.65930308
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65483096
24	Basal transcription factors_Homo sapiens_hsa03022	1.64262489
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.58258482
26	Homologous recombination_Homo sapiens_hsa03440	1.58081020
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.54796470
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.48512646
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.47864439
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.47149269
31	Parkinsons disease_Homo sapiens_hsa05012	1.46553160
32	Peroxisome_Homo sapiens_hsa04146	1.44458639
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.41263073
34	RNA polymerase_Homo sapiens_hsa03020	1.34119740
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.32191716
36	ABC transporters_Homo sapiens_hsa02010	1.30976089
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.29893245
38	Taste transduction_Homo sapiens_hsa04742	1.26432949
39	RNA degradation_Homo sapiens_hsa03018	1.26235931
40	Retinol metabolism_Homo sapiens_hsa00830	1.25983899
41	Regulation of autophagy_Homo sapiens_hsa04140	1.22026497
42	Circadian rhythm_Homo sapiens_hsa04710	1.21715162
43	Olfactory transduction_Homo sapiens_hsa04740	1.17434002
44	Morphine addiction_Homo sapiens_hsa05032	1.13446522
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07226949
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06522768
47	Serotonergic synapse_Homo sapiens_hsa04726	0.99362416
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97525356
49	GABAergic synapse_Homo sapiens_hsa04727	0.97459452
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.96080646
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95777332
52	Huntingtons disease_Homo sapiens_hsa05016	0.90839517
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87078666
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.84230248
55	Alzheimers disease_Homo sapiens_hsa05010	0.83253366
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81557790
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81300720
58	Non-homologous end-joining_Homo sapiens_hsa03450	0.79783529
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.77467725
60	Circadian entrainment_Homo sapiens_hsa04713	0.76983020
61	Insulin secretion_Homo sapiens_hsa04911	0.74804929
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.72418548
63	Sulfur metabolism_Homo sapiens_hsa00920	0.71577314
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70728558
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.70469340
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69373586
67	Mineral absorption_Homo sapiens_hsa04978	0.69128368
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.67962737
69	Fatty acid degradation_Homo sapiens_hsa00071	0.67638117
70	One carbon pool by folate_Homo sapiens_hsa00670	0.67616748
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65491963
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64425454
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.63312039
74	Metabolic pathways_Homo sapiens_hsa01100	0.61078948
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.59336497
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.59321988
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57713654
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57465763
79	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57219182
80	Purine metabolism_Homo sapiens_hsa00230	0.53743762
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.53189538
82	Salivary secretion_Homo sapiens_hsa04970	0.53178784
83	Proteasome_Homo sapiens_hsa03050	0.51865243
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49259020
85	Histidine metabolism_Homo sapiens_hsa00340	0.46520174
86	Dopaminergic synapse_Homo sapiens_hsa04728	0.42970368
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42583244
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41490529
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40941672
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.37846948
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36905224
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36683641
93	Cocaine addiction_Homo sapiens_hsa05030	0.34419630
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31581951
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29622482
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.28117321
97	Asthma_Homo sapiens_hsa05310	0.27228188
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27170632
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.26074651
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.25743650

ZNF442

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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