ZNF443

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these proteins, see ZNF91 (MIM 603971). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.63954742
2negative regulation of DNA-dependent DNA replication (GO:2000104)4.18403887
3regulation of mitotic spindle checkpoint (GO:1903504)4.03386384
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.03386384
5replication fork processing (GO:0031297)3.84404221
6negative regulation of DNA recombination (GO:0045910)3.81864227
7regulation of DNA endoreduplication (GO:0032875)3.81151174
8regulation of centriole replication (GO:0046599)3.75447093
9chromatin remodeling at centromere (GO:0031055)3.69317617
10CENP-A containing nucleosome assembly (GO:0034080)3.59859456
11resolution of meiotic recombination intermediates (GO:0000712)3.58278874
12DNA ligation (GO:0006266)3.57334550
13double-strand break repair via nonhomologous end joining (GO:0006303)3.54606682
14non-recombinational repair (GO:0000726)3.54606682
15DNA replication-dependent nucleosome organization (GO:0034723)3.51450896
16DNA replication-dependent nucleosome assembly (GO:0006335)3.51450896
17protein localization to kinetochore (GO:0034501)3.38926190
18synapsis (GO:0007129)3.33406963
19histone exchange (GO:0043486)3.31909704
20histone H2A acetylation (GO:0043968)3.28431616
21regulation of helicase activity (GO:0051095)3.23981853
22protein K6-linked ubiquitination (GO:0085020)3.23721395
23positive regulation of histone H3-K4 methylation (GO:0051571)3.23216481
24DNA integration (GO:0015074)3.14360312
25DNA catabolic process, exonucleolytic (GO:0000738)3.10353680
26centriole replication (GO:0007099)3.07948122
27DNA replication-independent nucleosome organization (GO:0034724)3.07440837
28DNA replication-independent nucleosome assembly (GO:0006336)3.07440837
29maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.06893836
30somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06291956
31somatic hypermutation of immunoglobulin genes (GO:0016446)3.06291956
32metaphase plate congression (GO:0051310)3.06061150
33regulation of sister chromatid cohesion (GO:0007063)3.03222362
34attachment of spindle microtubules to kinetochore (GO:0008608)3.00959658
35recombinational repair (GO:0000725)3.00874202
36nuclear pore organization (GO:0006999)2.99965238
37spindle checkpoint (GO:0031577)2.97630562
38DNA replication checkpoint (GO:0000076)2.96755211
39double-strand break repair via homologous recombination (GO:0000724)2.96436210
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95431838
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95431838
42positive regulation of mitotic sister chromatid separation (GO:1901970)2.95431838
43mitotic spindle checkpoint (GO:0071174)2.92108034
44retinal cone cell development (GO:0046549)2.90466449
45regulation of DNA methylation (GO:0044030)2.89678748
46organelle disassembly (GO:1903008)2.89265462
47intraciliary transport (GO:0042073)2.86731578
48telomere maintenance via semi-conservative replication (GO:0032201)2.84789748
49regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84139178
50regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84139178
51regulation of mitotic sister chromatid separation (GO:0010965)2.79949084
52regulation of mitotic sister chromatid segregation (GO:0033047)2.79949084
53regulation of sister chromatid segregation (GO:0033045)2.79949084
54protein polyglutamylation (GO:0018095)2.79698743
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79170610
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79170610
57negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79170610
58negative regulation of mitotic sister chromatid separation (GO:2000816)2.79170610
59negative regulation of sister chromatid segregation (GO:0033046)2.79170610
60mitotic recombination (GO:0006312)2.78089296
61negative regulation of chromosome segregation (GO:0051985)2.76981865
62response to pheromone (GO:0019236)2.75766587
63response to UV-C (GO:0010225)2.75341910
64negative regulation of axon guidance (GO:1902668)2.74582850
65regulation of double-strand break repair via homologous recombination (GO:0010569)2.73855714
66mitotic metaphase plate congression (GO:0007080)2.73402073
67regulation of meiosis I (GO:0060631)2.71943510
68lactate metabolic process (GO:0006089)2.71681555
69respiratory chain complex IV assembly (GO:0008535)2.70064096
70DNA topological change (GO:0006265)2.69990530
71pyrimidine nucleobase catabolic process (GO:0006208)2.69403356
72mitotic sister chromatid cohesion (GO:0007064)2.69279525
73regulation of chromosome segregation (GO:0051983)2.68748833
74ribonucleoprotein complex disassembly (GO:0032988)2.66621589
75double-strand break repair (GO:0006302)2.65113780
76water-soluble vitamin biosynthetic process (GO:0042364)2.64949592
77DNA strand elongation involved in DNA replication (GO:0006271)2.64741934
78sister chromatid cohesion (GO:0007062)2.63916370
79nuclear pore complex assembly (GO:0051292)2.63834524
80DNA recombination (GO:0006310)2.61166991
81regulation of centrosome cycle (GO:0046605)2.60962356
82telomere maintenance via recombination (GO:0000722)2.60428767
83kinetochore organization (GO:0051383)2.59371486
84binding of sperm to zona pellucida (GO:0007339)2.59282621
85base-excision repair (GO:0006284)2.59238568
86meiotic cell cycle (GO:0051321)2.58833123
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57709872
88isotype switching (GO:0045190)2.57709872
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57709872
90reciprocal meiotic recombination (GO:0007131)2.57691546
91reciprocal DNA recombination (GO:0035825)2.57691546
92mitotic spindle assembly checkpoint (GO:0007094)2.57593338
93positive regulation of chromosome segregation (GO:0051984)2.56712071
94telomere maintenance via telomere lengthening (GO:0010833)2.55597342
95mitochondrial DNA replication (GO:0006264)2.55018437
96response to X-ray (GO:0010165)2.54336586
97cullin deneddylation (GO:0010388)2.54101565
98spindle assembly checkpoint (GO:0071173)2.54027108
99limb bud formation (GO:0060174)2.53450937
100establishment of viral latency (GO:0019043)2.53120976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.11887692
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51170027
3E2F7_22180533_ChIP-Seq_HELA_Human3.43903406
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.23898848
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14524323
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00964171
7ZNF274_21170338_ChIP-Seq_K562_Hela2.64563981
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.52032316
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50064175
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43983628
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.42621350
12TAF15_26573619_Chip-Seq_HEK293_Human2.39029224
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36169759
14FUS_26573619_Chip-Seq_HEK293_Human2.33963323
15EWS_26573619_Chip-Seq_HEK293_Human2.25039923
16ELK1_19687146_ChIP-ChIP_HELA_Human2.19556081
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18392447
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10300318
19IRF1_19129219_ChIP-ChIP_H3396_Human2.07775106
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.06688528
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04046698
22PADI4_21655091_ChIP-ChIP_MCF-7_Human2.02436630
23GBX2_23144817_ChIP-Seq_PC3_Human2.01571739
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97090895
25IGF1R_20145208_ChIP-Seq_DFB_Human1.93534148
26P300_19829295_ChIP-Seq_ESCs_Human1.91469205
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88294483
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.80813276
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79059395
30MYC_18940864_ChIP-ChIP_HL60_Human1.77499402
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73053520
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71780177
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69502442
34VDR_23849224_ChIP-Seq_CD4+_Human1.69418606
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67051238
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.66446727
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64121207
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63816080
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56151266
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55564154
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55420059
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47524809
43FOXP3_21729870_ChIP-Seq_TREG_Human1.41894329
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40988267
45EZH2_22144423_ChIP-Seq_EOC_Human1.40498499
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38797903
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36554028
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35358964
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31989262
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31250563
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28598608
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.26987984
53ER_23166858_ChIP-Seq_MCF-7_Human1.26429987
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25499525
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22558734
56SMAD4_21799915_ChIP-Seq_A2780_Human1.21306570
57* CBP_20019798_ChIP-Seq_JUKART_Human1.20607175
58* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20607175
59VDR_22108803_ChIP-Seq_LS180_Human1.18938118
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17806653
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.17539384
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17518369
63TP53_22573176_ChIP-Seq_HFKS_Human1.17046236
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16463035
65AR_25329375_ChIP-Seq_VCAP_Human1.15523564
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15396869
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12970636
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10400618
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.10115291
70STAT3_23295773_ChIP-Seq_U87_Human1.09945920
71AR_21909140_ChIP-Seq_LNCAP_Human1.09640128
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.08642995
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07537403
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06581166
75TCF4_22108803_ChIP-Seq_LS180_Human1.06565956
76TCF4_23295773_ChIP-Seq_U87_Human1.06284792
77GABP_19822575_ChIP-Seq_HepG2_Human1.05483564
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.05034457
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04648974
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03128099
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.02983805
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02355589
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01238713
84* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00786919
85RNF2_27304074_Chip-Seq_NSC_Mouse1.00770193
86BCAT_22108803_ChIP-Seq_LS180_Human1.00575661
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.98955991
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96999983
89NFE2_27457419_Chip-Seq_LIVER_Mouse0.96895026
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96891881
91RUNX2_22187159_ChIP-Seq_PCA_Human0.96154386
92SOX2_19829295_ChIP-Seq_ESCs_Human0.93654125
93NANOG_19829295_ChIP-Seq_ESCs_Human0.93654125
94WT1_19549856_ChIP-ChIP_CCG9911_Human0.92325704
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92166503
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91905772
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91128969
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.91015160
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90699310
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90699310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.83957279
2MP0006292_abnormal_olfactory_placode3.80902093
3MP0008057_abnormal_DNA_replication3.30831024
4MP0001529_abnormal_vocalization3.28212868
5MP0003890_abnormal_embryonic-extraembry3.24284907
6MP0010094_abnormal_chromosome_stability2.92145771
7MP0003718_maternal_effect2.84286900
8MP0008058_abnormal_DNA_repair2.73923116
9MP0003121_genomic_imprinting2.64038645
10MP0003693_abnormal_embryo_hatching2.46601952
11MP0002102_abnormal_ear_morphology2.33993695
12MP0003787_abnormal_imprinting2.16548239
13MP0003122_maternal_imprinting2.12526325
14MP0006072_abnormal_retinal_apoptosis2.08128588
15MP0003880_abnormal_central_pattern2.06165578
16MP0001293_anophthalmia1.97349626
17MP0002751_abnormal_autonomic_nervous1.94785777
18MP0005084_abnormal_gallbladder_morpholo1.91389909
19MP0008789_abnormal_olfactory_epithelium1.82689882
20MP0008932_abnormal_embryonic_tissue1.80524962
21MP0003786_premature_aging1.80506713
22MP0003077_abnormal_cell_cycle1.77201810
23MP0006054_spinal_hemorrhage1.72970935
24MP0003195_calcinosis1.70662171
25MP0003111_abnormal_nucleus_morphology1.68401858
26MP0002234_abnormal_pharynx_morphology1.63361472
27MP0003937_abnormal_limbs/digits/tail_de1.62253625
28MP0008995_early_reproductive_senescence1.59539406
29MP0005394_taste/olfaction_phenotype1.59208329
30MP0005499_abnormal_olfactory_system1.59208329
31MP0003119_abnormal_digestive_system1.53725437
32MP0001984_abnormal_olfaction1.52531901
33MP0002233_abnormal_nose_morphology1.50723054
34MP0005253_abnormal_eye_physiology1.38402914
35MP0001929_abnormal_gametogenesis1.38289359
36MP0004957_abnormal_blastocyst_morpholog1.36413400
37MP0008007_abnormal_cellular_replicative1.35016917
38MP0003283_abnormal_digestive_organ1.31569913
39MP0000383_abnormal_hair_follicle1.31354859
40MP0006276_abnormal_autonomic_nervous1.31243530
41MP0002638_abnormal_pupillary_reflex1.30119061
42MP0002254_reproductive_system_inflammat1.25912585
43MP0002210_abnormal_sex_determination1.25250749
44MP0003941_abnormal_skin_development1.24771976
45MP0005367_renal/urinary_system_phenotyp1.23912365
46MP0000516_abnormal_urinary_system1.23912365
47MP0002822_catalepsy1.23865671
48MP0009697_abnormal_copulation1.15329255
49MP0000653_abnormal_sex_gland1.14372938
50MP0010678_abnormal_skin_adnexa1.11060319
51MP0003938_abnormal_ear_development1.10425079
52MP0002084_abnormal_developmental_patter1.09259006
53MP0005395_other_phenotype1.07027897
54MP0000631_abnormal_neuroendocrine_gland1.06949846
55MP0002938_white_spotting1.06085189
56MP0001145_abnormal_male_reproductive1.05871943
57MP0000427_abnormal_hair_cycle1.04635706
58MP0004133_heterotaxia1.03743229
59MP0005551_abnormal_eye_electrophysiolog1.02602235
60MP0005380_embryogenesis_phenotype1.00385314
61MP0001672_abnormal_embryogenesis/_devel1.00385314
62MP0001119_abnormal_female_reproductive0.99921434
63MP0001286_abnormal_eye_development0.98340263
64MP0003698_abnormal_male_reproductive0.96463911
65MP0002282_abnormal_trachea_morphology0.96414866
66MP0000778_abnormal_nervous_system0.95426848
67MP0001188_hyperpigmentation0.91649647
68MP0005391_vision/eye_phenotype0.90642415
69MP0003567_abnormal_fetal_cardiomyocyte0.89130725
70MP0009672_abnormal_birth_weight0.88407720
71MP0001697_abnormal_embryo_size0.87892496
72MP0006035_abnormal_mitochondrial_morpho0.85598551
73MP0004147_increased_porphyrin_level0.84391254
74MP0003221_abnormal_cardiomyocyte_apopto0.83270798
75MP0010030_abnormal_orbit_morphology0.83114582
76MP0001730_embryonic_growth_arrest0.82706485
77MP0002088_abnormal_embryonic_growth/wei0.82441459
78MP0002557_abnormal_social/conspecific_i0.81302337
79MP0005410_abnormal_fertilization0.80686222
80MP0003984_embryonic_growth_retardation0.79345865
81MP0005386_behavior/neurological_phenoty0.79227865
82MP0004924_abnormal_behavior0.79227865
83MP0002090_abnormal_vision0.79046643
84MP0000358_abnormal_cell_content/0.78370096
85MP0002085_abnormal_embryonic_tissue0.76485763
86MP0003861_abnormal_nervous_system0.76479511
87MP0002161_abnormal_fertility/fecundity0.76182158
88MP0002160_abnormal_reproductive_system0.76002044
89MP0009703_decreased_birth_body0.75346344
90MP0001986_abnormal_taste_sensitivity0.74812743
91MP0005645_abnormal_hypothalamus_physiol0.74417480
92MP0004197_abnormal_fetal_growth/weight/0.74271814
93MP0002736_abnormal_nociception_after0.73896856
94MP0001666_abnormal_nutrient_absorption0.71626319
95MP0010307_abnormal_tumor_latency0.69286929
96MP0002697_abnormal_eye_size0.69082554
97MP0000049_abnormal_middle_ear0.68709430
98MP0003699_abnormal_female_reproductive0.68243564
99MP0001486_abnormal_startle_reflex0.66964643
100MP0002272_abnormal_nervous_system0.66653471

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.82747461
2Methylmalonic acidemia (HP:0002912)3.48977055
3Chromsome breakage (HP:0040012)3.41552188
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35776641
5Volvulus (HP:0002580)3.23411236
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.01801075
7Meckel diverticulum (HP:0002245)2.94153546
8Abnormality of the ileum (HP:0001549)2.89599943
9Abnormality of chromosome stability (HP:0003220)2.82306660
10Medial flaring of the eyebrow (HP:0010747)2.80669950
11Pancreatic islet-cell hyperplasia (HP:0004510)2.80666163
12Intestinal atresia (HP:0011100)2.79531001
13Congenital primary aphakia (HP:0007707)2.75727126
14Gait imbalance (HP:0002141)2.70966240
15Methylmalonic aciduria (HP:0012120)2.70322389
16Abnormality of the preputium (HP:0100587)2.68337752
17Oligodactyly (hands) (HP:0001180)2.67873367
18Genital tract atresia (HP:0001827)2.61939005
19Vaginal atresia (HP:0000148)2.60137362
20Tubulointerstitial nephritis (HP:0001970)2.54364041
21Small intestinal stenosis (HP:0012848)2.54269184
22Duodenal stenosis (HP:0100867)2.54269184
23Abnormal lung lobation (HP:0002101)2.53634845
24Abnormal hair whorl (HP:0010721)2.50838256
25Abnormality of the duodenum (HP:0002246)2.49661849
26Nephrogenic diabetes insipidus (HP:0009806)2.47460933
27Aqueductal stenosis (HP:0002410)2.46144631
28Bifid tongue (HP:0010297)2.41797146
29Septo-optic dysplasia (HP:0100842)2.41156852
30Embryonal renal neoplasm (HP:0011794)2.38088035
31Colon cancer (HP:0003003)2.32948634
32Pancreatic cysts (HP:0001737)2.31751898
33Abnormality of vitamin B metabolism (HP:0004340)2.31016222
34Abnormality of the parathyroid morphology (HP:0011766)2.25402886
35Carpal bone hypoplasia (HP:0001498)2.24717223
36Labial hypoplasia (HP:0000066)2.23101952
37Hypoglycemic seizures (HP:0002173)2.23098884
38Clitoromegaly (HP:0000057)2.21808245
39Hypothermia (HP:0002045)2.21150565
40Abnormality of the vitamin B12 metabolism (HP:0004341)2.20679879
41True hermaphroditism (HP:0010459)2.17884604
42Renal cortical cysts (HP:0000803)2.15814422
43Abnormality of the pancreatic islet cells (HP:0006476)2.13126070
44Abnormality of endocrine pancreas physiology (HP:0012093)2.13126070
45Hyperglycinemia (HP:0002154)2.13085295
46Hypoplastic female external genitalia (HP:0012815)2.13013679
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11020284
48Oligodactyly (HP:0012165)2.09276938
49Disproportionate short-trunk short stature (HP:0003521)2.09178018
50Nephronophthisis (HP:0000090)2.09035248
51Growth hormone deficiency (HP:0000824)2.04909034
52Nephroblastoma (Wilms tumor) (HP:0002667)2.02180432
53Abnormality of the labia (HP:0000058)2.02127176
54Preaxial hand polydactyly (HP:0001177)2.01513285
55Triphalangeal thumb (HP:0001199)1.99971926
56Aplasia/Hypoplasia of the tongue (HP:0010295)1.98544435
57Rhabdomyosarcoma (HP:0002859)1.98028461
58Anophthalmia (HP:0000528)1.97739579
59Abnormality of the clitoris (HP:0000056)1.97484197
60Hyperinsulinemic hypoglycemia (HP:0000825)1.97361445
61Medulloblastoma (HP:0002885)1.97345882
62Specific learning disability (HP:0001328)1.97329337
63Abnormality of the renal cortex (HP:0011035)1.97215756
64Birth length less than 3rd percentile (HP:0003561)1.97023591
65Median cleft lip (HP:0000161)1.96572684
66Abnormality of methionine metabolism (HP:0010901)1.96527342
67Ependymoma (HP:0002888)1.96480362
68Hypoglycemic coma (HP:0001325)1.96067170
69Neoplasm of the adrenal gland (HP:0100631)1.95860518
70Abnormality of abdominal situs (HP:0011620)1.94820112
71Abdominal situs inversus (HP:0003363)1.94820112
72Pancreatic fibrosis (HP:0100732)1.94757166
73Absent radius (HP:0003974)1.93757302
74Adrenal hypoplasia (HP:0000835)1.93670067
75Papillary thyroid carcinoma (HP:0002895)1.93376792
76Cortical dysplasia (HP:0002539)1.91284650
77Ectopic kidney (HP:0000086)1.90381675
78Broad foot (HP:0001769)1.88578472
79Supernumerary spleens (HP:0009799)1.88269549
80Decreased testicular size (HP:0008734)1.88252221
81Sloping forehead (HP:0000340)1.87949034
82Abnormality of the astrocytes (HP:0100707)1.85609766
83Astrocytoma (HP:0009592)1.85609766
84Failure to thrive in infancy (HP:0001531)1.82923712
85Aplasia involving forearm bones (HP:0009822)1.82522864
86Absent forearm bone (HP:0003953)1.82522864
87Bilateral microphthalmos (HP:0007633)1.82020481
88Molar tooth sign on MRI (HP:0002419)1.81198656
89Abnormality of midbrain morphology (HP:0002418)1.81198656
90Abnormality of the renal medulla (HP:0100957)1.80662684
91Poor coordination (HP:0002370)1.80116762
92Glioma (HP:0009733)1.79749748
93Myelomeningocele (HP:0002475)1.78322433
94Broad alveolar ridges (HP:0000187)1.78089915
95Horseshoe kidney (HP:0000085)1.77616556
96Postaxial foot polydactyly (HP:0001830)1.76672503
97Abnormality of the carotid arteries (HP:0005344)1.76003046
98Micropenis (HP:0000054)1.75863270
99Postaxial hand polydactyly (HP:0001162)1.74284891
100Long foot (HP:0001833)1.72287785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.41650001
2MAP4K23.12594178
3TRIM282.99903604
4BMPR1B2.81084685
5SRPK12.76607570
6MAP3K42.52335638
7BRSK22.50209112
8WNK32.45591185
9TTK2.42346092
10ZAK2.35048084
11BUB12.34123123
12ACVR1B2.25654698
13MST42.24933615
14TNIK2.23329516
15EIF2AK32.22179802
16TSSK62.09141102
17ERBB32.04537312
18PLK41.96368907
19WEE11.90692299
20MKNK21.87915671
21PBK1.83663203
22PLK31.80619699
23FRK1.79519440
24BCR1.79362801
25STK161.79216435
26MAPK131.71419826
27CDC71.71289179
28STK38L1.67838360
29GRK11.66266636
30MKNK11.63280694
31STK241.62040679
32MAP2K71.54665771
33NUAK11.52470893
34PLK21.50749963
35PLK11.39097772
36DYRK31.34069671
37PNCK1.33284721
38BCKDK1.32521027
39ADRBK21.15610047
40PAK31.14835977
41CSNK1G11.12690672
42BRSK11.09406055
43CSNK1G21.08132200
44CSNK1G31.05348843
45NEK11.00075947
46TGFBR10.98918102
47RPS6KA40.94288468
48BRAF0.91668981
49MARK10.89657645
50CSNK1A1L0.89511206
51FER0.89439965
52ATR0.81588872
53EPHA40.79997088
54DYRK20.77417362
55STK30.74930233
56VRK10.74199342
57ATM0.73519599
58CHEK20.73313406
59PINK10.73284356
60PRKCI0.72015678
61BRD40.70838618
62CASK0.68228885
63PRKCG0.58548369
64AKT30.58050818
65MET0.57318669
66STK390.55039874
67MINK10.52422084
68KSR10.52165742
69ERBB40.51469238
70CHEK10.50180810
71EIF2AK20.49552465
72FLT30.49461413
73OXSR10.48673876
74PRKCE0.47397739
75TAF10.47162479
76AURKB0.46222278
77SIK30.45805334
78PKN10.43721968
79RAF10.43112469
80FGFR10.37929792
81MAPKAPK50.37349853
82CDK10.32283747
83CSNK1E0.32090608
84CDK70.30882152
85YES10.30802393
86STK40.30786585
87MAP3K90.30057907
88CSNK2A10.28320846
89CDK90.28067424
90LIMK10.27249222
91TNK20.27188227
92PRKACB0.27149620
93AURKA0.26686934
94CSNK1A10.25830521
95CDK30.25314806
96PRKDC0.24802232
97NEK20.24424080
98RPS6KB10.22279545
99CDK20.21813973
100CSNK2A20.21131925

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.48843374
2Homologous recombination_Homo sapiens_hsa034403.08756891
3Fanconi anemia pathway_Homo sapiens_hsa034602.96760926
4Propanoate metabolism_Homo sapiens_hsa006402.91699218
5Protein export_Homo sapiens_hsa030602.81579043
6Mismatch repair_Homo sapiens_hsa034302.67616161
7DNA replication_Homo sapiens_hsa030302.57046893
8Steroid biosynthesis_Homo sapiens_hsa001002.41099288
9Basal transcription factors_Homo sapiens_hsa030222.31370243
10Base excision repair_Homo sapiens_hsa034102.29174002
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22493411
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10073630
13Cell cycle_Homo sapiens_hsa041102.07324434
14RNA degradation_Homo sapiens_hsa030182.05781560
15Proteasome_Homo sapiens_hsa030502.02128266
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86257356
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83647196
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82154052
19RNA transport_Homo sapiens_hsa030131.81361275
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71755567
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.69312931
22Oocyte meiosis_Homo sapiens_hsa041141.63060669
23Nucleotide excision repair_Homo sapiens_hsa034201.56397838
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50509723
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47628897
26RNA polymerase_Homo sapiens_hsa030201.45438173
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43235913
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35379573
29Peroxisome_Homo sapiens_hsa041461.33808723
30Fatty acid elongation_Homo sapiens_hsa000621.32401142
31Vitamin B6 metabolism_Homo sapiens_hsa007501.32338898
32Spliceosome_Homo sapiens_hsa030401.30286365
33Folate biosynthesis_Homo sapiens_hsa007901.29166019
34Circadian rhythm_Homo sapiens_hsa047101.24617043
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22547632
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20273664
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19393063
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18864000
39Phototransduction_Homo sapiens_hsa047441.15470358
40Butanoate metabolism_Homo sapiens_hsa006501.15311671
41mRNA surveillance pathway_Homo sapiens_hsa030151.08483885
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05456322
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05187702
44Caffeine metabolism_Homo sapiens_hsa002321.04882880
45Pyruvate metabolism_Homo sapiens_hsa006201.04645822
46Fatty acid metabolism_Homo sapiens_hsa012120.95784586
47Selenocompound metabolism_Homo sapiens_hsa004500.92478412
48Purine metabolism_Homo sapiens_hsa002300.92167824
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85941436
50Pyrimidine metabolism_Homo sapiens_hsa002400.85826984
51Ether lipid metabolism_Homo sapiens_hsa005650.85368421
52Oxidative phosphorylation_Homo sapiens_hsa001900.83472003
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82407856
54Tryptophan metabolism_Homo sapiens_hsa003800.81622208
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.77240776
56Basal cell carcinoma_Homo sapiens_hsa052170.75483988
57Parkinsons disease_Homo sapiens_hsa050120.72330949
58p53 signaling pathway_Homo sapiens_hsa041150.70831854
59Regulation of autophagy_Homo sapiens_hsa041400.69614258
60Lysine degradation_Homo sapiens_hsa003100.69512354
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69307323
62Hedgehog signaling pathway_Homo sapiens_hsa043400.68947150
63Olfactory transduction_Homo sapiens_hsa047400.68714701
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67679460
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66870655
66Metabolic pathways_Homo sapiens_hsa011000.66686133
67Nicotine addiction_Homo sapiens_hsa050330.64866671
68Sulfur metabolism_Homo sapiens_hsa009200.63400235
69TGF-beta signaling pathway_Homo sapiens_hsa043500.61104502
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60121039
71Fatty acid degradation_Homo sapiens_hsa000710.59780336
72One carbon pool by folate_Homo sapiens_hsa006700.58497506
73Carbon metabolism_Homo sapiens_hsa012000.58120037
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57858928
75Biosynthesis of amino acids_Homo sapiens_hsa012300.56370297
76Huntingtons disease_Homo sapiens_hsa050160.54890913
77Glutathione metabolism_Homo sapiens_hsa004800.54484669
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54448152
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51527655
80Collecting duct acid secretion_Homo sapiens_hsa049660.47884973
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47762346
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47525881
83Hippo signaling pathway_Homo sapiens_hsa043900.46450260
84beta-Alanine metabolism_Homo sapiens_hsa004100.45296274
85Retinol metabolism_Homo sapiens_hsa008300.44700059
86Arginine and proline metabolism_Homo sapiens_hsa003300.44215113
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42988853
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39665145
89Arginine biosynthesis_Homo sapiens_hsa002200.38961000
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38615978
91Taste transduction_Homo sapiens_hsa047420.36674921
92N-Glycan biosynthesis_Homo sapiens_hsa005100.35648547
93Sphingolipid metabolism_Homo sapiens_hsa006000.33292352
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33265698
95Fat digestion and absorption_Homo sapiens_hsa049750.32906386
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32570336
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31010627
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.30514171
99Wnt signaling pathway_Homo sapiens_hsa043100.29435066
100Linoleic acid metabolism_Homo sapiens_hsa005910.28969803

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