ZNF444

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activation of MAPKKK activity (GO:0000185)4.97964074
2cell-cell junction maintenance (GO:0045217)4.36576662
3regulation of synapse maturation (GO:0090128)4.10807756
4positive regulation of histone deacetylation (GO:0031065)4.07248353
5motile cilium assembly (GO:0044458)4.06287718
6peptidyl-glutamic acid carboxylation (GO:0017187)3.96527241
7protein carboxylation (GO:0018214)3.96527241
8lung epithelium development (GO:0060428)3.95433693
9positive regulation of synapse maturation (GO:0090129)3.88309329
10cell migration in hindbrain (GO:0021535)3.68151968
11intracellular estrogen receptor signaling pathway (GO:0030520)3.58022966
12response to misfolded protein (GO:0051788)3.47847358
13regulation of hydrogen peroxide metabolic process (GO:0010310)3.47032778
14cell junction maintenance (GO:0034331)3.44572304
15negative regulation of cell size (GO:0045792)3.31918178
16proline metabolic process (GO:0006560)3.29978634
17histone H4 deacetylation (GO:0070933)3.19864580
18positive regulation of CREB transcription factor activity (GO:0032793)3.16744791
19protein insertion into membrane (GO:0051205)3.11669331
20regulation of cholesterol biosynthetic process (GO:0045540)3.11374602
21positive regulation of protein kinase C signaling (GO:0090037)3.10571256
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.10404846
23histone H3 deacetylation (GO:0070932)3.09049676
24axonemal dynein complex assembly (GO:0070286)3.06184061
25regulation of ARF GTPase activity (GO:0032312)3.05447204
26ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.99329336
27negative regulation of sterol transport (GO:0032372)2.98602332
28negative regulation of cholesterol transport (GO:0032375)2.98602332
29regulation of cholesterol metabolic process (GO:0090181)2.98122637
30semaphorin-plexin signaling pathway (GO:0071526)2.97948155
31cilium or flagellum-dependent cell motility (GO:0001539)2.95440360
32planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91557698
33positive regulation of protein deacetylation (GO:0090312)2.86375435
34regulation of histone deacetylation (GO:0031063)2.81423893
35rRNA transcription (GO:0009303)2.81261639
36regulation of fatty acid beta-oxidation (GO:0031998)2.80233608
37phosphatidylethanolamine biosynthetic process (GO:0006646)2.79833161
38protein retention in ER lumen (GO:0006621)2.79724759
39regulation of glycogen (starch) synthase activity (GO:2000465)2.78465886
40positive regulation of triglyceride lipase activity (GO:0061365)2.78188409
41positive regulation of lipoprotein lipase activity (GO:0051006)2.78188409
42apoptotic process involved in morphogenesis (GO:0060561)2.77025620
43neuronal ion channel clustering (GO:0045161)2.75052251
44regulation of cholesterol homeostasis (GO:2000188)2.73171375
45mannose metabolic process (GO:0006013)2.70595985
46L-phenylalanine metabolic process (GO:0006558)2.67624543
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.67624543
48diacylglycerol metabolic process (GO:0046339)2.66938944
49negative regulation of DNA-templated transcription, elongation (GO:0032785)2.65944504
50L-phenylalanine catabolic process (GO:0006559)2.65673646
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65673646
52proline biosynthetic process (GO:0006561)2.65125799
53cellular response to pH (GO:0071467)2.61339954
54high-density lipoprotein particle remodeling (GO:0034375)2.59657252
55sperm capacitation (GO:0048240)2.59194973
56positive regulation of fatty acid beta-oxidation (GO:0032000)2.59150611
57peptidyl-arginine omega-N-methylation (GO:0035247)2.58176337
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55154735
59synaptic vesicle docking involved in exocytosis (GO:0016081)2.55127605
604-hydroxyproline metabolic process (GO:0019471)2.54633192
61establishment of apical/basal cell polarity (GO:0035089)2.52811267
62opioid receptor signaling pathway (GO:0038003)2.52587298
63negative regulation of viral release from host cell (GO:1902187)2.52494213
64establishment of mitochondrion localization (GO:0051654)2.52197230
65mitochondrion transport along microtubule (GO:0047497)2.52073913
66establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52073913
67regulation of cholesterol esterification (GO:0010872)2.52054088
68regulation of ARF protein signal transduction (GO:0032012)2.51547877
69entrainment of circadian clock by photoperiod (GO:0043153)2.51318664
70glyoxylate metabolic process (GO:0046487)2.51195796
71positive regulation of triglyceride metabolic process (GO:0090208)2.50634196
72tooth mineralization (GO:0034505)2.49750098
73complement activation, alternative pathway (GO:0006957)2.48364502
74regulation of autophagic vacuole assembly (GO:2000785)2.48234412
75peptidyl-glutamic acid modification (GO:0018200)2.46479320
76reverse cholesterol transport (GO:0043691)2.46435381
77regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45618374
78phosphatidylglycerol biosynthetic process (GO:0006655)2.44197370
79phosphatidylethanolamine metabolic process (GO:0046337)2.44126682
80phospholipid efflux (GO:0033700)2.43843387
81positive regulation of triglyceride biosynthetic process (GO:0010867)2.42036192
82regulation of fibrinolysis (GO:0051917)2.41294567
83regulation of chromatin binding (GO:0035561)2.40741997
84protein-lipid complex remodeling (GO:0034368)2.39616492
85macromolecular complex remodeling (GO:0034367)2.39616492
86plasma lipoprotein particle remodeling (GO:0034369)2.39616492
87endothelial cell chemotaxis (GO:0035767)2.39282627
88GDP-mannose metabolic process (GO:0019673)2.38804740
89dorsal/ventral neural tube patterning (GO:0021904)2.38506464
90synaptic vesicle exocytosis (GO:0016079)2.37802628
91negative regulation of fibrinolysis (GO:0051918)2.36815268
92positive regulation of gene expression, epigenetic (GO:0045815)2.36271757
93glutathione biosynthetic process (GO:0006750)2.36028666
94regulation of interleukin-13 production (GO:0032656)2.35511093
95negative regulation of cAMP-mediated signaling (GO:0043951)2.35349043
96positive regulation of lipid catabolic process (GO:0050996)2.34953123
97regulation of protein activation cascade (GO:2000257)2.34290045
98ethanol metabolic process (GO:0006067)2.33901286
99regulation of apoptotic process involved in morphogenesis (GO:1902337)2.32213107
100serine family amino acid catabolic process (GO:0009071)2.31362697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.01201783
2LXR_22292898_ChIP-Seq_THP-1_Human3.29593481
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.29129738
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.90100635
5P68_20966046_ChIP-Seq_HELA_Human2.58422165
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.39256302
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.35743833
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30917258
9VDR_21846776_ChIP-Seq_THP-1_Human2.25693562
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.15931071
11MYC_22102868_ChIP-Seq_BL_Human2.11598017
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.10338671
13SMC4_20622854_ChIP-Seq_HELA_Human2.10191241
14* RACK7_27058665_Chip-Seq_MCF-7_Human2.07931762
15CTCF_27219007_Chip-Seq_Bcells_Human2.05601422
16TET1_21451524_ChIP-Seq_MESCs_Mouse2.03216813
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03125960
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02212161
19KDM2B_26808549_Chip-Seq_DND41_Human1.99723748
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99088187
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98150093
22DROSHA_22980978_ChIP-Seq_HELA_Human1.96737091
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.96660162
24* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.95605839
25DNAJC2_21179169_ChIP-ChIP_NT2_Human1.93222556
26BCL6_27268052_Chip-Seq_Bcells_Human1.82173336
27* SA1_27219007_Chip-Seq_ERYTHROID_Human1.81785981
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.81667992
29SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.80843547
30KDM2B_26808549_Chip-Seq_K562_Human1.79852756
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78355777
32* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77730636
33CREB1_26743006_Chip-Seq_LNCaP_Human1.75820858
34TCF7_22412390_ChIP-Seq_EML_Mouse1.74456555
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.73204217
36BCOR_27268052_Chip-Seq_Bcells_Human1.72774891
37E2F1_20622854_ChIP-Seq_HELA_Human1.69295734
38SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69200492
39PHF8_20622854_ChIP-Seq_HELA_Human1.64866028
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57468862
41* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52510658
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.49621978
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46811815
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46797729
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46067565
46SA1_27219007_Chip-Seq_Bcells_Human1.45200253
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44944972
48* CTCF_20526341_ChIP-Seq_ESCs_Human1.42366312
49MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.42141455
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41991601
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.41717861
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40038705
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.39828015
54RARB_24833708_ChIP-Seq_LIVER_Mouse1.39498588
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39011072
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37690372
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36619542
58TP63_22573176_ChIP-Seq_HFKS_Human1.36044609
59OCT4_19829295_ChIP-Seq_ESCs_Human1.36010957
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.34959997
61TP53_22127205_ChIP-Seq_IMR90_Human1.31455720
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.31104157
63MAF_26560356_Chip-Seq_TH2_Human1.30994655
64RARA_24833708_ChIP-Seq_LIVER_Mouse1.30114948
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.28092903
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25501685
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.25325663
68* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22477004
69* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22214424
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19999996
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19695475
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.19556214
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18380626
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18335530
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16801336
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15802546
77* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13677480
78SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12435610
79CTCF_26484167_Chip-Seq_Bcells_Mouse1.12071926
80ERA_21632823_ChIP-Seq_H3396_Human1.10763078
81CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10405879
82ETS1_21867929_ChIP-Seq_TH2_Mouse1.10404410
83CTCF_21964334_Chip-Seq_Bcells_Human1.09872237
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08966488
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08367185
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07804263
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.07166220
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06389931
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06155437
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05136792
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02956380
92UTX_26944678_Chip-Seq_JUKART_Human1.02854630
93MAF_26560356_Chip-Seq_TH1_Human1.01111590
94P300_27268052_Chip-Seq_Bcells_Human1.00804186
95SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00499639
96* RAC3_21632823_ChIP-Seq_H3396_Human0.99218128
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98793172
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.98620876
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98009785
100TP53_20018659_ChIP-ChIP_R1E_Mouse0.97725797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002249_abnormal_larynx_morphology3.62739582
2MP0002653_abnormal_ependyma_morphology3.12942399
3MP0005623_abnormal_meninges_morphology2.82498627
4MP0005451_abnormal_body_composition2.75388548
5MP0004859_abnormal_synaptic_plasticity2.67417635
6MP0005360_urolithiasis2.61428696
7MP0000678_abnormal_parathyroid_gland2.61369152
8MP0003172_abnormal_lysosome_physiology2.53695581
9MP0000566_synostosis2.50713725
10MP0003878_abnormal_ear_physiology2.49686780
11MP0005377_hearing/vestibular/ear_phenot2.49686780
12MP0001348_abnormal_lacrimal_gland2.48731539
13MP0002139_abnormal_hepatobiliary_system2.44680661
14MP0005670_abnormal_white_adipose2.27590559
15MP0009384_cardiac_valve_regurgitation2.24853477
16MP0008875_abnormal_xenobiotic_pharmacok2.17297788
17MP0005365_abnormal_bile_salt2.13102597
18MP0004858_abnormal_nervous_system2.09125011
19MP0000003_abnormal_adipose_tissue1.96061645
20MP0000013_abnormal_adipose_tissue1.90847675
21MP0003122_maternal_imprinting1.90267348
22MP0003123_paternal_imprinting1.89480891
23MP0003879_abnormal_hair_cell1.88591936
24MP0002089_abnormal_postnatal_growth/wei1.77390010
25MP0005058_abnormal_lysosome_morphology1.76901737
26MP0001502_abnormal_circadian_rhythm1.70221254
27MP0001849_ear_inflammation1.58601408
28MP0009840_abnormal_foam_cell1.52783519
29MP0004133_heterotaxia1.49008532
30MP0009278_abnormal_bone_marrow1.47587220
31MP0003329_amyloid_beta_deposits1.46644102
32MP0005423_abnormal_somatic_nervous1.45327479
33MP0010329_abnormal_lipoprotein_level1.42388301
34MP0005076_abnormal_cell_differentiation1.39062209
35MP0005083_abnormal_biliary_tract1.35964140
36MP0000750_abnormal_muscle_regeneration1.24090714
37MP0005410_abnormal_fertilization1.22565881
38MP0005375_adipose_tissue_phenotype1.21615392
39MP0003787_abnormal_imprinting1.20999714
40MP0002063_abnormal_learning/memory/cond1.19321716
41MP0003705_abnormal_hypodermis_morpholog1.19233856
42MP0000681_abnormal_thyroid_gland1.19138126
43MP0002138_abnormal_hepatobiliary_system1.18830985
44MP0001270_distended_abdomen1.16356649
45MP0003942_abnormal_urinary_system1.14750642
46MP0001346_abnormal_lacrimal_gland1.14365951
47MP0003635_abnormal_synaptic_transmissio1.12154111
48MP0002132_abnormal_respiratory_system1.11232706
49MP0001873_stomach_inflammation1.09029330
50MP0000049_abnormal_middle_ear1.08517222
51MP0002572_abnormal_emotion/affect_behav1.05601477
52MP0002064_seizures1.05172751
53MP0003115_abnormal_respiratory_system1.01817944
54MP0002557_abnormal_social/conspecific_i0.99234607
55MP0000026_abnormal_inner_ear0.97666578
56MP0002254_reproductive_system_inflammat0.94310940
57MP0005499_abnormal_olfactory_system0.88962967
58MP0005394_taste/olfaction_phenotype0.88962967
59MP0000955_abnormal_spinal_cord0.87128792
60MP0001968_abnormal_touch/_nociception0.86696555
61MP0003938_abnormal_ear_development0.86555139
62MP0003698_abnormal_male_reproductive0.86535798
63MP0002733_abnormal_thermal_nociception0.85649086
64MP0002118_abnormal_lipid_homeostasis0.85097422
65MP0010030_abnormal_orbit_morphology0.84574410
66MP0001486_abnormal_startle_reflex0.83317489
67MP0002876_abnormal_thyroid_physiology0.81774945
68MP0001944_abnormal_pancreas_morphology0.81419857
69MP0002932_abnormal_joint_morphology0.80840641
70MP0004130_abnormal_muscle_cell0.80610831
71MP0002116_abnormal_craniofacial_bone0.80338853
72MP0009745_abnormal_behavioral_response0.79038964
73MP0002933_joint_inflammation0.77491322
74MP0003861_abnormal_nervous_system0.76431894
75MP0005666_abnormal_adipose_tissue0.76105619
76MP0000609_abnormal_liver_physiology0.75042190
77MP0002152_abnormal_brain_morphology0.74656556
78MP0008260_abnormal_autophagy0.74284273
79MP0002882_abnormal_neuron_morphology0.73555737
80MP0001963_abnormal_hearing_physiology0.72340899
81MP0003195_calcinosis0.71460619
82MP0005085_abnormal_gallbladder_physiolo0.70820156
83MP0000534_abnormal_ureter_morphology0.69810433
84MP0001970_abnormal_pain_threshold0.69758108
85MP0004043_abnormal_pH_regulation0.67391983
86MP0002161_abnormal_fertility/fecundity0.67244888
87MP0002970_abnormal_white_adipose0.62570404
88MP0003183_abnormal_peptide_metabolism0.62287273
89MP0005220_abnormal_exocrine_pancreas0.61956962
90MP0001765_abnormal_ion_homeostasis0.61419188
91MP0002928_abnormal_bile_duct0.60456674
92MP0000778_abnormal_nervous_system0.59980960
93MP0005167_abnormal_blood-brain_barrier0.59942470
94MP0008872_abnormal_physiological_respon0.59818251
95MP0005379_endocrine/exocrine_gland_phen0.59573490
96MP0002735_abnormal_chemical_nociception0.58952671
97MP0005332_abnormal_amino_acid0.58834654
98MP0002229_neurodegeneration0.58748157
99MP0002752_abnormal_somatic_nervous0.58553768
100MP0004264_abnormal_extraembryonic_tissu0.58032038

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)4.51531869
2Deep venous thrombosis (HP:0002625)4.09451921
3Obstructive sleep apnea (HP:0002870)3.68078644
4Stridor (HP:0010307)3.65487018
5Retinal dysplasia (HP:0007973)3.59906157
6Abnormality of the aortic arch (HP:0012303)3.53194638
7Cerebellar dysplasia (HP:0007033)3.49398945
8Hemorrhage of the eye (HP:0011885)3.46673826
9Nasal polyposis (HP:0100582)3.28984223
10J-shaped sella turcica (HP:0002680)3.28701636
11Type II lissencephaly (HP:0007260)3.19042826
12Hyperacusis (HP:0010780)3.00119886
13Lymphangioma (HP:0100764)2.97124968
14Abnormality of the nasal mucosa (HP:0000433)2.84527333
15Distal upper limb amyotrophy (HP:0007149)2.83008181
16Upper limb amyotrophy (HP:0009129)2.83008181
17Rectal prolapse (HP:0002035)2.81584719
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.78810235
19Bronchomalacia (HP:0002780)2.73251940
20Atelectasis (HP:0100750)2.70092212
21Hyperthyroidism (HP:0000836)2.70041968
22Absent/shortened dynein arms (HP:0200106)2.56269567
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.56269567
24Hand muscle atrophy (HP:0009130)2.52907771
25Difficulty climbing stairs (HP:0003551)2.48427831
26Truncus arteriosus (HP:0001660)2.41962761
27Abnormal respiratory epithelium morphology (HP:0012253)2.41239692
28Abnormal respiratory motile cilium morphology (HP:0005938)2.41239692
29Supranuclear gaze palsy (HP:0000605)2.40944934
30Mesangial abnormality (HP:0001966)2.38131349
31Broad distal phalanx of finger (HP:0009836)2.35846984
32Buphthalmos (HP:0000557)2.35759019
33Complement deficiency (HP:0004431)2.34260192
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.31548954
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29337229
36Abnormality of polysaccharide metabolism (HP:0011012)2.29337229
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29337229
38Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27340745
39Absent epiphyses (HP:0010577)2.27340745
40Xanthomatosis (HP:0000991)2.20413415
41Severe muscular hypotonia (HP:0006829)2.18138050
42Ankle clonus (HP:0011448)2.16140883
43Joint hemorrhage (HP:0005261)2.14295327
44Recurrent otitis media (HP:0000403)2.12795088
45Mucopolysacchariduria (HP:0008155)2.12761717
46Urinary glycosaminoglycan excretion (HP:0003541)2.12761717
47Prolonged partial thromboplastin time (HP:0003645)2.11809670
48Annular pancreas (HP:0001734)2.08580326
49Ulnar bowing (HP:0003031)2.04046269
50Renal dysplasia (HP:0000110)2.03034056
51Hypoplasia of the pons (HP:0012110)2.02436946
52Renovascular hypertension (HP:0100817)2.00448567
53Broad face (HP:0000283)2.00159200
54Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.98776778
55Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98648822
56Flattened epiphyses (HP:0003071)1.98532926
57Abnormality of the thoracic spine (HP:0100711)1.97766407
58Abnormality of complement system (HP:0005339)1.97762429
59Megalocornea (HP:0000485)1.97231408
60Abnormality of the vitreous humor (HP:0004327)1.95338682
61Vitreoretinal degeneration (HP:0000655)1.93607262
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93271316
63Occipital encephalocele (HP:0002085)1.92648217
64Turricephaly (HP:0000262)1.92428217
65Increased cerebral lipofuscin (HP:0011813)1.91655853
66Cerebral aneurysm (HP:0004944)1.88155833
67Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88100518
68Abnormality of the intervertebral disk (HP:0005108)1.85592970
69Short femoral neck (HP:0100864)1.82707368
70Congenital glaucoma (HP:0001087)1.80450155
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79675430
72Deep palmar crease (HP:0006191)1.79643084
73Clumsiness (HP:0002312)1.79516465
74Cerebral palsy (HP:0100021)1.78960476
75Genetic anticipation (HP:0003743)1.74924219
76Reticulocytosis (HP:0001923)1.74778296
77Pointed chin (HP:0000307)1.70108056
78Systemic lupus erythematosus (HP:0002725)1.70067912
79Optic nerve coloboma (HP:0000588)1.67261404
80Abnormality of aromatic amino acid family metabolism (HP:0004338)1.65966161
81Hypercortisolism (HP:0001578)1.65774526
82Flat acetabular roof (HP:0003180)1.65731001
83Thoracic kyphosis (HP:0002942)1.65303410
84Abnormality of the lower motor neuron (HP:0002366)1.64865260
85Emphysema (HP:0002097)1.64200181
86Visual hallucinations (HP:0002367)1.64008997
87Metaphyseal cupping (HP:0003021)1.63786465
88Late onset (HP:0003584)1.63524405
89Easy fatigability (HP:0003388)1.61420955
90Long palpebral fissure (HP:0000637)1.61166445
91Elfin facies (HP:0004428)1.60408635
92Abnormal ciliary motility (HP:0012262)1.59968777
93Sleep apnea (HP:0010535)1.59960101
94Aplasia/Hypoplasia of the brainstem (HP:0007362)1.59438435
95Hypoplasia of the brainstem (HP:0002365)1.59438435
96Cystic liver disease (HP:0006706)1.59366360
97Myokymia (HP:0002411)1.59011835
98Abnormality of the parathyroid morphology (HP:0011766)1.58537044
99Precocious puberty (HP:0000826)1.58416828
100Abnormal respiratory motile cilium physiology (HP:0012261)1.55823270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.38968508
2SIK13.44645579
3SMG13.04079918
4ICK2.99761639
5ERN12.84080053
6FGFR42.44677203
7EEF2K2.42404389
8SIK22.35631436
9PRKD32.32112690
10EPHA22.12066921
11MAP3K111.94699378
12CDK121.91687040
13MAP4K11.84592673
14MAPK151.83589777
15MARK21.83173839
16TNK21.64941919
17MAP3K131.50981884
18LMTK21.40111638
19TESK11.38082959
20RIPK11.37488053
21TYRO31.36216718
22PKN21.35277968
23IRAK31.31064457
24CAMKK11.27413820
25MAP2K21.24897851
26HIPK21.23277304
27CDC42BPA1.20982431
28MARK31.17832658
29MAPKAPK31.15716495
30MAP3K71.13291301
31RPS6KA21.13104855
32PRKD21.12998395
33MAPK111.11569171
34STK381.04492529
35DYRK1B1.03352334
36ARAF1.02930581
37PDPK11.02703040
38PRPF4B0.98915726
39MTOR0.98675969
40MAP3K100.95965981
41STK110.93224292
42PTK60.89306281
43RPS6KC10.84779347
44RPS6KL10.84779347
45DAPK20.80906812
46NTRK30.79065239
47RPS6KA60.76817498
48WNK40.76761090
49TAOK10.75235345
50EPHA40.73472816
51EPHB10.72173596
52MAP3K90.71766954
53CAMK1D0.71473343
54NME10.71230481
55CHUK0.68858111
56GRK60.68792794
57FGFR20.67834872
58PRKCI0.66724867
59PRKAA10.66245634
60PIM20.65561753
61PDK10.65560601
62PRKCH0.64933748
63TLK10.63763776
64BCKDK0.63524050
65PRKCZ0.63127684
66MAP2K60.61826368
67DDR20.60393461
68UHMK10.57551900
69NTRK20.57260212
70BRAF0.55260593
71BMX0.54898993
72CDK70.52420309
73FGFR30.52258354
74CDK40.51372661
75MAPK80.50615164
76KDR0.50318479
77NME20.49915609
78PTK2B0.45856897
79MAP3K10.45541011
80SIK30.45038059
81DAPK10.44620395
82CAMK10.44604922
83PHKG10.43841077
84PHKG20.43841077
85PRKAA20.43178249
86MARK10.43018060
87TBK10.42109771
88RPS6KA10.39979720
89TAOK20.38264206
90PKN10.35780893
91CAMK40.34143737
92ERBB20.33539175
93GSK3B0.33288910
94ILK0.32852271
95CDK90.32786481
96CAMK1G0.32387279
97MAPK120.32315452
98RET0.31088246
99PRKG20.30697364
100IKBKB0.29914752

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.49420478
2Sulfur relay system_Homo sapiens_hsa041223.00095280
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94151275
4Notch signaling pathway_Homo sapiens_hsa043302.48464112
5Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.47355745
6Phenylalanine metabolism_Homo sapiens_hsa003602.32999342
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.27290243
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10408645
9Other glycan degradation_Homo sapiens_hsa005111.74577440
10Complement and coagulation cascades_Homo sapiens_hsa046101.71206832
11Arginine biosynthesis_Homo sapiens_hsa002201.70285664
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61943728
13AMPK signaling pathway_Homo sapiens_hsa041521.58770717
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54594753
15ABC transporters_Homo sapiens_hsa020101.52763521
16Bile secretion_Homo sapiens_hsa049761.46115555
17Lysine degradation_Homo sapiens_hsa003101.39330702
18Fructose and mannose metabolism_Homo sapiens_hsa000511.39020713
19Synaptic vesicle cycle_Homo sapiens_hsa047211.34174480
20Arginine and proline metabolism_Homo sapiens_hsa003301.34108618
21Prion diseases_Homo sapiens_hsa050201.33865789
22VEGF signaling pathway_Homo sapiens_hsa043701.30425504
23Histidine metabolism_Homo sapiens_hsa003401.25894682
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.23664719
25Vitamin B6 metabolism_Homo sapiens_hsa007501.23467446
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18643329
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17799844
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.13518972
29Biosynthesis of amino acids_Homo sapiens_hsa012301.13390837
30Insulin resistance_Homo sapiens_hsa049311.13272682
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12632996
32Tyrosine metabolism_Homo sapiens_hsa003501.11731860
33mTOR signaling pathway_Homo sapiens_hsa041501.08914571
34Acute myeloid leukemia_Homo sapiens_hsa052211.07621169
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07017743
36Fat digestion and absorption_Homo sapiens_hsa049751.01188199
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01169795
38Insulin signaling pathway_Homo sapiens_hsa049101.00865493
39Insulin secretion_Homo sapiens_hsa049111.00495249
40Maturity onset diabetes of the young_Homo sapiens_hsa049500.98341782
41Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98249819
42Glucagon signaling pathway_Homo sapiens_hsa049220.95695221
43Fatty acid degradation_Homo sapiens_hsa000710.91432106
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84852318
45PPAR signaling pathway_Homo sapiens_hsa033200.84427175
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83870687
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83858483
48Linoleic acid metabolism_Homo sapiens_hsa005910.83506303
49Choline metabolism in cancer_Homo sapiens_hsa052310.79314088
50Fatty acid biosynthesis_Homo sapiens_hsa000610.78874622
51Non-small cell lung cancer_Homo sapiens_hsa052230.74053165
52Cocaine addiction_Homo sapiens_hsa050300.73341429
53Axon guidance_Homo sapiens_hsa043600.73318072
54Bladder cancer_Homo sapiens_hsa052190.71979825
55Type II diabetes mellitus_Homo sapiens_hsa049300.70803185
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69615259
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69596424
58Primary immunodeficiency_Homo sapiens_hsa053400.69328767
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69003912
60Retinol metabolism_Homo sapiens_hsa008300.67643387
61Fatty acid metabolism_Homo sapiens_hsa012120.67026122
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65700485
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63410508
64Chronic myeloid leukemia_Homo sapiens_hsa052200.63285399
65Basal cell carcinoma_Homo sapiens_hsa052170.62379012
66ErbB signaling pathway_Homo sapiens_hsa040120.61058718
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60829326
68Lysosome_Homo sapiens_hsa041420.59076751
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.58234888
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57619344
71Chemical carcinogenesis_Homo sapiens_hsa052040.57362482
72Cholinergic synapse_Homo sapiens_hsa047250.57242782
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.57107160
74Pentose phosphate pathway_Homo sapiens_hsa000300.57033222
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56857659
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55717139
77Estrogen signaling pathway_Homo sapiens_hsa049150.54154082
78Butanoate metabolism_Homo sapiens_hsa006500.53430246
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.53340227
80Endocytosis_Homo sapiens_hsa041440.52281990
81Thyroid hormone synthesis_Homo sapiens_hsa049180.51471887
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.51389132
83Glioma_Homo sapiens_hsa052140.50860935
84Dopaminergic synapse_Homo sapiens_hsa047280.50075137
85Vibrio cholerae infection_Homo sapiens_hsa051100.49738232
86B cell receptor signaling pathway_Homo sapiens_hsa046620.49086493
87MAPK signaling pathway_Homo sapiens_hsa040100.47774997
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47551781
89Inositol phosphate metabolism_Homo sapiens_hsa005620.44934119
90Hepatitis C_Homo sapiens_hsa051600.44127876
91Melanogenesis_Homo sapiens_hsa049160.43913616
92Endometrial cancer_Homo sapiens_hsa052130.42799214
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41900931
94Gastric acid secretion_Homo sapiens_hsa049710.41109824
95Amphetamine addiction_Homo sapiens_hsa050310.40640751
96Glycerolipid metabolism_Homo sapiens_hsa005610.40604297
97Arachidonic acid metabolism_Homo sapiens_hsa005900.38903205
98Caffeine metabolism_Homo sapiens_hsa002320.38305099
99T cell receptor signaling pathway_Homo sapiens_hsa046600.36603537
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33456077

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