Rank | Gene Set | Z-score |
---|---|---|
1 | activation of MAPKKK activity (GO:0000185) | 4.97964074 |
2 | cell-cell junction maintenance (GO:0045217) | 4.36576662 |
3 | regulation of synapse maturation (GO:0090128) | 4.10807756 |
4 | positive regulation of histone deacetylation (GO:0031065) | 4.07248353 |
5 | motile cilium assembly (GO:0044458) | 4.06287718 |
6 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.96527241 |
7 | protein carboxylation (GO:0018214) | 3.96527241 |
8 | lung epithelium development (GO:0060428) | 3.95433693 |
9 | positive regulation of synapse maturation (GO:0090129) | 3.88309329 |
10 | cell migration in hindbrain (GO:0021535) | 3.68151968 |
11 | intracellular estrogen receptor signaling pathway (GO:0030520) | 3.58022966 |
12 | response to misfolded protein (GO:0051788) | 3.47847358 |
13 | regulation of hydrogen peroxide metabolic process (GO:0010310) | 3.47032778 |
14 | cell junction maintenance (GO:0034331) | 3.44572304 |
15 | negative regulation of cell size (GO:0045792) | 3.31918178 |
16 | proline metabolic process (GO:0006560) | 3.29978634 |
17 | histone H4 deacetylation (GO:0070933) | 3.19864580 |
18 | positive regulation of CREB transcription factor activity (GO:0032793) | 3.16744791 |
19 | protein insertion into membrane (GO:0051205) | 3.11669331 |
20 | regulation of cholesterol biosynthetic process (GO:0045540) | 3.11374602 |
21 | positive regulation of protein kinase C signaling (GO:0090037) | 3.10571256 |
22 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.10404846 |
23 | histone H3 deacetylation (GO:0070932) | 3.09049676 |
24 | axonemal dynein complex assembly (GO:0070286) | 3.06184061 |
25 | regulation of ARF GTPase activity (GO:0032312) | 3.05447204 |
26 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316 | 2.99329336 |
27 | negative regulation of sterol transport (GO:0032372) | 2.98602332 |
28 | negative regulation of cholesterol transport (GO:0032375) | 2.98602332 |
29 | regulation of cholesterol metabolic process (GO:0090181) | 2.98122637 |
30 | semaphorin-plexin signaling pathway (GO:0071526) | 2.97948155 |
31 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.95440360 |
32 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.91557698 |
33 | positive regulation of protein deacetylation (GO:0090312) | 2.86375435 |
34 | regulation of histone deacetylation (GO:0031063) | 2.81423893 |
35 | rRNA transcription (GO:0009303) | 2.81261639 |
36 | regulation of fatty acid beta-oxidation (GO:0031998) | 2.80233608 |
37 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 2.79833161 |
38 | protein retention in ER lumen (GO:0006621) | 2.79724759 |
39 | regulation of glycogen (starch) synthase activity (GO:2000465) | 2.78465886 |
40 | positive regulation of triglyceride lipase activity (GO:0061365) | 2.78188409 |
41 | positive regulation of lipoprotein lipase activity (GO:0051006) | 2.78188409 |
42 | apoptotic process involved in morphogenesis (GO:0060561) | 2.77025620 |
43 | neuronal ion channel clustering (GO:0045161) | 2.75052251 |
44 | regulation of cholesterol homeostasis (GO:2000188) | 2.73171375 |
45 | mannose metabolic process (GO:0006013) | 2.70595985 |
46 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.67624543 |
47 | L-phenylalanine metabolic process (GO:0006558) | 2.67624543 |
48 | diacylglycerol metabolic process (GO:0046339) | 2.66938944 |
49 | negative regulation of DNA-templated transcription, elongation (GO:0032785) | 2.65944504 |
50 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 2.65673646 |
51 | L-phenylalanine catabolic process (GO:0006559) | 2.65673646 |
52 | proline biosynthetic process (GO:0006561) | 2.65125799 |
53 | cellular response to pH (GO:0071467) | 2.61339954 |
54 | high-density lipoprotein particle remodeling (GO:0034375) | 2.59657252 |
55 | sperm capacitation (GO:0048240) | 2.59194973 |
56 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 2.59150611 |
57 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.58176337 |
58 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.55154735 |
59 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.55127605 |
60 | 4-hydroxyproline metabolic process (GO:0019471) | 2.54633192 |
61 | establishment of apical/basal cell polarity (GO:0035089) | 2.52811267 |
62 | opioid receptor signaling pathway (GO:0038003) | 2.52587298 |
63 | negative regulation of viral release from host cell (GO:1902187) | 2.52494213 |
64 | establishment of mitochondrion localization (GO:0051654) | 2.52197230 |
65 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.52073913 |
66 | mitochondrion transport along microtubule (GO:0047497) | 2.52073913 |
67 | regulation of cholesterol esterification (GO:0010872) | 2.52054088 |
68 | regulation of ARF protein signal transduction (GO:0032012) | 2.51547877 |
69 | entrainment of circadian clock by photoperiod (GO:0043153) | 2.51318664 |
70 | glyoxylate metabolic process (GO:0046487) | 2.51195796 |
71 | positive regulation of triglyceride metabolic process (GO:0090208) | 2.50634196 |
72 | tooth mineralization (GO:0034505) | 2.49750098 |
73 | complement activation, alternative pathway (GO:0006957) | 2.48364502 |
74 | regulation of autophagic vacuole assembly (GO:2000785) | 2.48234412 |
75 | peptidyl-glutamic acid modification (GO:0018200) | 2.46479320 |
76 | reverse cholesterol transport (GO:0043691) | 2.46435381 |
77 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.45618374 |
78 | phosphatidylglycerol biosynthetic process (GO:0006655) | 2.44197370 |
79 | phosphatidylethanolamine metabolic process (GO:0046337) | 2.44126682 |
80 | phospholipid efflux (GO:0033700) | 2.43843387 |
81 | positive regulation of triglyceride biosynthetic process (GO:0010867) | 2.42036192 |
82 | regulation of fibrinolysis (GO:0051917) | 2.41294567 |
83 | regulation of chromatin binding (GO:0035561) | 2.40741997 |
84 | protein-lipid complex remodeling (GO:0034368) | 2.39616492 |
85 | macromolecular complex remodeling (GO:0034367) | 2.39616492 |
86 | plasma lipoprotein particle remodeling (GO:0034369) | 2.39616492 |
87 | endothelial cell chemotaxis (GO:0035767) | 2.39282627 |
88 | GDP-mannose metabolic process (GO:0019673) | 2.38804740 |
89 | dorsal/ventral neural tube patterning (GO:0021904) | 2.38506464 |
90 | synaptic vesicle exocytosis (GO:0016079) | 2.37802628 |
91 | negative regulation of fibrinolysis (GO:0051918) | 2.36815268 |
92 | positive regulation of gene expression, epigenetic (GO:0045815) | 2.36271757 |
93 | glutathione biosynthetic process (GO:0006750) | 2.36028666 |
94 | regulation of interleukin-13 production (GO:0032656) | 2.35511093 |
95 | negative regulation of cAMP-mediated signaling (GO:0043951) | 2.35349043 |
96 | positive regulation of lipid catabolic process (GO:0050996) | 2.34953123 |
97 | regulation of protein activation cascade (GO:2000257) | 2.34290045 |
98 | ethanol metabolic process (GO:0006067) | 2.33901286 |
99 | regulation of apoptotic process involved in morphogenesis (GO:1902337) | 2.32213107 |
100 | serine family amino acid catabolic process (GO:0009071) | 2.31362697 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 4.01201783 |
2 | LXR_22292898_ChIP-Seq_THP-1_Human | 3.29593481 |
3 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 3.29129738 |
4 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.90100635 |
5 | P68_20966046_ChIP-Seq_HELA_Human | 2.58422165 |
6 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.39256302 |
7 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 2.35743833 |
8 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.30917258 |
9 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.25693562 |
10 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 2.15931071 |
11 | MYC_22102868_ChIP-Seq_BL_Human | 2.11598017 |
12 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.10338671 |
13 | SMC4_20622854_ChIP-Seq_HELA_Human | 2.10191241 |
14 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 2.07931762 |
15 | CTCF_27219007_Chip-Seq_Bcells_Human | 2.05601422 |
16 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 2.03216813 |
17 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.03125960 |
18 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.02212161 |
19 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.99723748 |
20 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.99088187 |
21 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.98150093 |
22 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.96737091 |
23 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.96660162 |
24 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.95605839 |
25 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.93222556 |
26 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.82173336 |
27 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.81785981 |
28 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.81667992 |
29 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.80843547 |
30 | KDM2B_26808549_Chip-Seq_K562_Human | 1.79852756 |
31 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.78355777 |
32 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.77730636 |
33 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.75820858 |
34 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.74456555 |
35 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.73204217 |
36 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.72774891 |
37 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.69295734 |
38 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.69200492 |
39 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.64866028 |
40 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.57468862 |
41 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.52510658 |
42 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.49621978 |
43 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.46811815 |
44 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.46797729 |
45 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.46067565 |
46 | SA1_27219007_Chip-Seq_Bcells_Human | 1.45200253 |
47 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.44944972 |
48 | * CTCF_20526341_ChIP-Seq_ESCs_Human | 1.42366312 |
49 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.42141455 |
50 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.41991601 |
51 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.41717861 |
52 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.40038705 |
53 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.39828015 |
54 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 1.39498588 |
55 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.39011072 |
56 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.37690372 |
57 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.36619542 |
58 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.36044609 |
59 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.36010957 |
60 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.34959997 |
61 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.31455720 |
62 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.31104157 |
63 | MAF_26560356_Chip-Seq_TH2_Human | 1.30994655 |
64 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.30114948 |
65 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.28092903 |
66 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.25501685 |
67 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.25325663 |
68 | * EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.22477004 |
69 | * TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 1.22214424 |
70 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.19999996 |
71 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.19695475 |
72 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.19556214 |
73 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.18380626 |
74 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.18335530 |
75 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.16801336 |
76 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.15802546 |
77 | * RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.13677480 |
78 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.12435610 |
79 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.12071926 |
80 | ERA_21632823_ChIP-Seq_H3396_Human | 1.10763078 |
81 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.10405879 |
82 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 1.10404410 |
83 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.09872237 |
84 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.08966488 |
85 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.08367185 |
86 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07804263 |
87 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.07166220 |
88 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 1.06389931 |
89 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.06155437 |
90 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.05136792 |
91 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.02956380 |
92 | UTX_26944678_Chip-Seq_JUKART_Human | 1.02854630 |
93 | MAF_26560356_Chip-Seq_TH1_Human | 1.01111590 |
94 | P300_27268052_Chip-Seq_Bcells_Human | 1.00804186 |
95 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.00499639 |
96 | * RAC3_21632823_ChIP-Seq_H3396_Human | 0.99218128 |
97 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.98793172 |
98 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.98620876 |
99 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.98009785 |
100 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.97725797 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002249_abnormal_larynx_morphology | 3.62739582 |
2 | MP0002653_abnormal_ependyma_morphology | 3.12942399 |
3 | MP0005623_abnormal_meninges_morphology | 2.82498627 |
4 | MP0005451_abnormal_body_composition | 2.75388548 |
5 | MP0004859_abnormal_synaptic_plasticity | 2.67417635 |
6 | MP0005360_urolithiasis | 2.61428696 |
7 | MP0000678_abnormal_parathyroid_gland | 2.61369152 |
8 | MP0003172_abnormal_lysosome_physiology | 2.53695581 |
9 | MP0000566_synostosis | 2.50713725 |
10 | MP0005377_hearing/vestibular/ear_phenot | 2.49686780 |
11 | MP0003878_abnormal_ear_physiology | 2.49686780 |
12 | MP0001348_abnormal_lacrimal_gland | 2.48731539 |
13 | MP0002139_abnormal_hepatobiliary_system | 2.44680661 |
14 | MP0005670_abnormal_white_adipose | 2.27590559 |
15 | MP0009384_cardiac_valve_regurgitation | 2.24853477 |
16 | MP0008875_abnormal_xenobiotic_pharmacok | 2.17297788 |
17 | MP0005365_abnormal_bile_salt | 2.13102597 |
18 | MP0004858_abnormal_nervous_system | 2.09125011 |
19 | MP0000003_abnormal_adipose_tissue | 1.96061645 |
20 | MP0000013_abnormal_adipose_tissue | 1.90847675 |
21 | MP0003122_maternal_imprinting | 1.90267348 |
22 | MP0003123_paternal_imprinting | 1.89480891 |
23 | MP0003879_abnormal_hair_cell | 1.88591936 |
24 | MP0002089_abnormal_postnatal_growth/wei | 1.77390010 |
25 | MP0005058_abnormal_lysosome_morphology | 1.76901737 |
26 | MP0001502_abnormal_circadian_rhythm | 1.70221254 |
27 | MP0001849_ear_inflammation | 1.58601408 |
28 | MP0009840_abnormal_foam_cell | 1.52783519 |
29 | MP0004133_heterotaxia | 1.49008532 |
30 | MP0009278_abnormal_bone_marrow | 1.47587220 |
31 | MP0003329_amyloid_beta_deposits | 1.46644102 |
32 | MP0005423_abnormal_somatic_nervous | 1.45327479 |
33 | MP0010329_abnormal_lipoprotein_level | 1.42388301 |
34 | MP0005076_abnormal_cell_differentiation | 1.39062209 |
35 | MP0005083_abnormal_biliary_tract | 1.35964140 |
36 | MP0000750_abnormal_muscle_regeneration | 1.24090714 |
37 | MP0005410_abnormal_fertilization | 1.22565881 |
38 | MP0005375_adipose_tissue_phenotype | 1.21615392 |
39 | MP0003787_abnormal_imprinting | 1.20999714 |
40 | MP0002063_abnormal_learning/memory/cond | 1.19321716 |
41 | MP0003705_abnormal_hypodermis_morpholog | 1.19233856 |
42 | MP0000681_abnormal_thyroid_gland | 1.19138126 |
43 | MP0002138_abnormal_hepatobiliary_system | 1.18830985 |
44 | MP0001270_distended_abdomen | 1.16356649 |
45 | MP0003942_abnormal_urinary_system | 1.14750642 |
46 | MP0001346_abnormal_lacrimal_gland | 1.14365951 |
47 | MP0003635_abnormal_synaptic_transmissio | 1.12154111 |
48 | MP0002132_abnormal_respiratory_system | 1.11232706 |
49 | MP0001873_stomach_inflammation | 1.09029330 |
50 | MP0000049_abnormal_middle_ear | 1.08517222 |
51 | MP0002572_abnormal_emotion/affect_behav | 1.05601477 |
52 | MP0002064_seizures | 1.05172751 |
53 | MP0003115_abnormal_respiratory_system | 1.01817944 |
54 | MP0002557_abnormal_social/conspecific_i | 0.99234607 |
55 | MP0000026_abnormal_inner_ear | 0.97666578 |
56 | MP0002254_reproductive_system_inflammat | 0.94310940 |
57 | MP0005394_taste/olfaction_phenotype | 0.88962967 |
58 | MP0005499_abnormal_olfactory_system | 0.88962967 |
59 | MP0000955_abnormal_spinal_cord | 0.87128792 |
60 | MP0001968_abnormal_touch/_nociception | 0.86696555 |
61 | MP0003938_abnormal_ear_development | 0.86555139 |
62 | MP0003698_abnormal_male_reproductive | 0.86535798 |
63 | MP0002733_abnormal_thermal_nociception | 0.85649086 |
64 | MP0002118_abnormal_lipid_homeostasis | 0.85097422 |
65 | MP0010030_abnormal_orbit_morphology | 0.84574410 |
66 | MP0001486_abnormal_startle_reflex | 0.83317489 |
67 | MP0002876_abnormal_thyroid_physiology | 0.81774945 |
68 | MP0001944_abnormal_pancreas_morphology | 0.81419857 |
69 | MP0002932_abnormal_joint_morphology | 0.80840641 |
70 | MP0004130_abnormal_muscle_cell | 0.80610831 |
71 | MP0002116_abnormal_craniofacial_bone | 0.80338853 |
72 | MP0009745_abnormal_behavioral_response | 0.79038964 |
73 | MP0002933_joint_inflammation | 0.77491322 |
74 | MP0003861_abnormal_nervous_system | 0.76431894 |
75 | MP0005666_abnormal_adipose_tissue | 0.76105619 |
76 | MP0000609_abnormal_liver_physiology | 0.75042190 |
77 | MP0002152_abnormal_brain_morphology | 0.74656556 |
78 | MP0008260_abnormal_autophagy | 0.74284273 |
79 | MP0002882_abnormal_neuron_morphology | 0.73555737 |
80 | MP0001963_abnormal_hearing_physiology | 0.72340899 |
81 | MP0003195_calcinosis | 0.71460619 |
82 | MP0005085_abnormal_gallbladder_physiolo | 0.70820156 |
83 | MP0000534_abnormal_ureter_morphology | 0.69810433 |
84 | MP0001970_abnormal_pain_threshold | 0.69758108 |
85 | MP0004043_abnormal_pH_regulation | 0.67391983 |
86 | MP0002161_abnormal_fertility/fecundity | 0.67244888 |
87 | MP0002970_abnormal_white_adipose | 0.62570404 |
88 | MP0003183_abnormal_peptide_metabolism | 0.62287273 |
89 | MP0005220_abnormal_exocrine_pancreas | 0.61956962 |
90 | MP0001765_abnormal_ion_homeostasis | 0.61419188 |
91 | MP0002928_abnormal_bile_duct | 0.60456674 |
92 | MP0000778_abnormal_nervous_system | 0.59980960 |
93 | MP0005167_abnormal_blood-brain_barrier | 0.59942470 |
94 | MP0008872_abnormal_physiological_respon | 0.59818251 |
95 | MP0005379_endocrine/exocrine_gland_phen | 0.59573490 |
96 | MP0002735_abnormal_chemical_nociception | 0.58952671 |
97 | MP0005332_abnormal_amino_acid | 0.58834654 |
98 | MP0002229_neurodegeneration | 0.58748157 |
99 | MP0002752_abnormal_somatic_nervous | 0.58553768 |
100 | MP0004264_abnormal_extraembryonic_tissu | 0.58032038 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Retinal atrophy (HP:0001105) | 4.51531869 |
2 | Deep venous thrombosis (HP:0002625) | 4.09451921 |
3 | Obstructive sleep apnea (HP:0002870) | 3.68078644 |
4 | Stridor (HP:0010307) | 3.65487018 |
5 | Retinal dysplasia (HP:0007973) | 3.59906157 |
6 | Abnormality of the aortic arch (HP:0012303) | 3.53194638 |
7 | Cerebellar dysplasia (HP:0007033) | 3.49398945 |
8 | Hemorrhage of the eye (HP:0011885) | 3.46673826 |
9 | Nasal polyposis (HP:0100582) | 3.28984223 |
10 | J-shaped sella turcica (HP:0002680) | 3.28701636 |
11 | Type II lissencephaly (HP:0007260) | 3.19042826 |
12 | Hyperacusis (HP:0010780) | 3.00119886 |
13 | Lymphangioma (HP:0100764) | 2.97124968 |
14 | Abnormality of the nasal mucosa (HP:0000433) | 2.84527333 |
15 | Distal upper limb amyotrophy (HP:0007149) | 2.83008181 |
16 | Upper limb amyotrophy (HP:0009129) | 2.83008181 |
17 | Rectal prolapse (HP:0002035) | 2.81584719 |
18 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.78810235 |
19 | Bronchomalacia (HP:0002780) | 2.73251940 |
20 | Atelectasis (HP:0100750) | 2.70092212 |
21 | Hyperthyroidism (HP:0000836) | 2.70041968 |
22 | Absent/shortened dynein arms (HP:0200106) | 2.56269567 |
23 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.56269567 |
24 | Hand muscle atrophy (HP:0009130) | 2.52907771 |
25 | Difficulty climbing stairs (HP:0003551) | 2.48427831 |
26 | Truncus arteriosus (HP:0001660) | 2.41962761 |
27 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.41239692 |
28 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.41239692 |
29 | Supranuclear gaze palsy (HP:0000605) | 2.40944934 |
30 | Mesangial abnormality (HP:0001966) | 2.38131349 |
31 | Broad distal phalanx of finger (HP:0009836) | 2.35846984 |
32 | Buphthalmos (HP:0000557) | 2.35759019 |
33 | Complement deficiency (HP:0004431) | 2.34260192 |
34 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.31548954 |
35 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.29337229 |
36 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.29337229 |
37 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.29337229 |
38 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.27340745 |
39 | Absent epiphyses (HP:0010577) | 2.27340745 |
40 | Xanthomatosis (HP:0000991) | 2.20413415 |
41 | Severe muscular hypotonia (HP:0006829) | 2.18138050 |
42 | Ankle clonus (HP:0011448) | 2.16140883 |
43 | Joint hemorrhage (HP:0005261) | 2.14295327 |
44 | Recurrent otitis media (HP:0000403) | 2.12795088 |
45 | Mucopolysacchariduria (HP:0008155) | 2.12761717 |
46 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.12761717 |
47 | Prolonged partial thromboplastin time (HP:0003645) | 2.11809670 |
48 | Annular pancreas (HP:0001734) | 2.08580326 |
49 | Ulnar bowing (HP:0003031) | 2.04046269 |
50 | Renal dysplasia (HP:0000110) | 2.03034056 |
51 | Hypoplasia of the pons (HP:0012110) | 2.02436946 |
52 | Renovascular hypertension (HP:0100817) | 2.00448567 |
53 | Broad face (HP:0000283) | 2.00159200 |
54 | Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108) | 1.98776778 |
55 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.98648822 |
56 | Flattened epiphyses (HP:0003071) | 1.98532926 |
57 | Abnormality of the thoracic spine (HP:0100711) | 1.97766407 |
58 | Abnormality of complement system (HP:0005339) | 1.97762429 |
59 | Megalocornea (HP:0000485) | 1.97231408 |
60 | Abnormality of the vitreous humor (HP:0004327) | 1.95338682 |
61 | Vitreoretinal degeneration (HP:0000655) | 1.93607262 |
62 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.93271316 |
63 | Occipital encephalocele (HP:0002085) | 1.92648217 |
64 | Turricephaly (HP:0000262) | 1.92428217 |
65 | Increased cerebral lipofuscin (HP:0011813) | 1.91655853 |
66 | Cerebral aneurysm (HP:0004944) | 1.88155833 |
67 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.88100518 |
68 | Abnormality of the intervertebral disk (HP:0005108) | 1.85592970 |
69 | Short femoral neck (HP:0100864) | 1.82707368 |
70 | Congenital glaucoma (HP:0001087) | 1.80450155 |
71 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.79675430 |
72 | Deep palmar crease (HP:0006191) | 1.79643084 |
73 | Clumsiness (HP:0002312) | 1.79516465 |
74 | Cerebral palsy (HP:0100021) | 1.78960476 |
75 | Genetic anticipation (HP:0003743) | 1.74924219 |
76 | Reticulocytosis (HP:0001923) | 1.74778296 |
77 | Pointed chin (HP:0000307) | 1.70108056 |
78 | Systemic lupus erythematosus (HP:0002725) | 1.70067912 |
79 | Optic nerve coloboma (HP:0000588) | 1.67261404 |
80 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.65966161 |
81 | Hypercortisolism (HP:0001578) | 1.65774526 |
82 | Flat acetabular roof (HP:0003180) | 1.65731001 |
83 | Thoracic kyphosis (HP:0002942) | 1.65303410 |
84 | Abnormality of the lower motor neuron (HP:0002366) | 1.64865260 |
85 | Emphysema (HP:0002097) | 1.64200181 |
86 | Visual hallucinations (HP:0002367) | 1.64008997 |
87 | Metaphyseal cupping (HP:0003021) | 1.63786465 |
88 | Late onset (HP:0003584) | 1.63524405 |
89 | Easy fatigability (HP:0003388) | 1.61420955 |
90 | Long palpebral fissure (HP:0000637) | 1.61166445 |
91 | Elfin facies (HP:0004428) | 1.60408635 |
92 | Abnormal ciliary motility (HP:0012262) | 1.59968777 |
93 | Sleep apnea (HP:0010535) | 1.59960101 |
94 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.59438435 |
95 | Hypoplasia of the brainstem (HP:0002365) | 1.59438435 |
96 | Cystic liver disease (HP:0006706) | 1.59366360 |
97 | Myokymia (HP:0002411) | 1.59011835 |
98 | Abnormality of the parathyroid morphology (HP:0011766) | 1.58537044 |
99 | Precocious puberty (HP:0000826) | 1.58416828 |
100 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.55823270 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TRIB3 | 5.38968508 |
2 | SIK1 | 3.44645579 |
3 | SMG1 | 3.04079918 |
4 | ICK | 2.99761639 |
5 | ERN1 | 2.84080053 |
6 | FGFR4 | 2.44677203 |
7 | EEF2K | 2.42404389 |
8 | SIK2 | 2.35631436 |
9 | PRKD3 | 2.32112690 |
10 | EPHA2 | 2.12066921 |
11 | MAP3K11 | 1.94699378 |
12 | CDK12 | 1.91687040 |
13 | MAP4K1 | 1.84592673 |
14 | MAPK15 | 1.83589777 |
15 | MARK2 | 1.83173839 |
16 | TNK2 | 1.64941919 |
17 | MAP3K13 | 1.50981884 |
18 | LMTK2 | 1.40111638 |
19 | TESK1 | 1.38082959 |
20 | RIPK1 | 1.37488053 |
21 | TYRO3 | 1.36216718 |
22 | PKN2 | 1.35277968 |
23 | IRAK3 | 1.31064457 |
24 | CAMKK1 | 1.27413820 |
25 | MAP2K2 | 1.24897851 |
26 | HIPK2 | 1.23277304 |
27 | CDC42BPA | 1.20982431 |
28 | MARK3 | 1.17832658 |
29 | MAPKAPK3 | 1.15716495 |
30 | MAP3K7 | 1.13291301 |
31 | RPS6KA2 | 1.13104855 |
32 | PRKD2 | 1.12998395 |
33 | MAPK11 | 1.11569171 |
34 | STK38 | 1.04492529 |
35 | DYRK1B | 1.03352334 |
36 | ARAF | 1.02930581 |
37 | PDPK1 | 1.02703040 |
38 | PRPF4B | 0.98915726 |
39 | MTOR | 0.98675969 |
40 | MAP3K10 | 0.95965981 |
41 | STK11 | 0.93224292 |
42 | PTK6 | 0.89306281 |
43 | RPS6KC1 | 0.84779347 |
44 | RPS6KL1 | 0.84779347 |
45 | DAPK2 | 0.80906812 |
46 | NTRK3 | 0.79065239 |
47 | RPS6KA6 | 0.76817498 |
48 | WNK4 | 0.76761090 |
49 | TAOK1 | 0.75235345 |
50 | EPHA4 | 0.73472816 |
51 | EPHB1 | 0.72173596 |
52 | MAP3K9 | 0.71766954 |
53 | CAMK1D | 0.71473343 |
54 | NME1 | 0.71230481 |
55 | CHUK | 0.68858111 |
56 | GRK6 | 0.68792794 |
57 | FGFR2 | 0.67834872 |
58 | PRKCI | 0.66724867 |
59 | PRKAA1 | 0.66245634 |
60 | PIM2 | 0.65561753 |
61 | PDK1 | 0.65560601 |
62 | PRKCH | 0.64933748 |
63 | TLK1 | 0.63763776 |
64 | BCKDK | 0.63524050 |
65 | PRKCZ | 0.63127684 |
66 | MAP2K6 | 0.61826368 |
67 | DDR2 | 0.60393461 |
68 | UHMK1 | 0.57551900 |
69 | NTRK2 | 0.57260212 |
70 | BRAF | 0.55260593 |
71 | BMX | 0.54898993 |
72 | CDK7 | 0.52420309 |
73 | FGFR3 | 0.52258354 |
74 | CDK4 | 0.51372661 |
75 | MAPK8 | 0.50615164 |
76 | KDR | 0.50318479 |
77 | NME2 | 0.49915609 |
78 | PTK2B | 0.45856897 |
79 | MAP3K1 | 0.45541011 |
80 | SIK3 | 0.45038059 |
81 | DAPK1 | 0.44620395 |
82 | CAMK1 | 0.44604922 |
83 | PHKG1 | 0.43841077 |
84 | PHKG2 | 0.43841077 |
85 | PRKAA2 | 0.43178249 |
86 | MARK1 | 0.43018060 |
87 | TBK1 | 0.42109771 |
88 | RPS6KA1 | 0.39979720 |
89 | TAOK2 | 0.38264206 |
90 | PKN1 | 0.35780893 |
91 | CAMK4 | 0.34143737 |
92 | ERBB2 | 0.33539175 |
93 | GSK3B | 0.33288910 |
94 | ILK | 0.32852271 |
95 | CDK9 | 0.32786481 |
96 | CAMK1G | 0.32387279 |
97 | MAPK12 | 0.32315452 |
98 | RET | 0.31088246 |
99 | PRKG2 | 0.30697364 |
100 | IKBKB | 0.29914752 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 3.49420478 |
2 | Sulfur relay system_Homo sapiens_hsa04122 | 3.00095280 |
3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.94151275 |
4 | Notch signaling pathway_Homo sapiens_hsa04330 | 2.48464112 |
5 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 2.47355745 |
6 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 2.32999342 |
7 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.27290243 |
8 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.10408645 |
9 | Other glycan degradation_Homo sapiens_hsa00511 | 1.74577440 |
10 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.71206832 |
11 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.70285664 |
12 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.61943728 |
13 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.58770717 |
14 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.54594753 |
15 | ABC transporters_Homo sapiens_hsa02010 | 1.52763521 |
16 | Bile secretion_Homo sapiens_hsa04976 | 1.46115555 |
17 | Lysine degradation_Homo sapiens_hsa00310 | 1.39330702 |
18 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.39020713 |
19 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.34174480 |
20 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.34108618 |
21 | Prion diseases_Homo sapiens_hsa05020 | 1.33865789 |
22 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.30425504 |
23 | Histidine metabolism_Homo sapiens_hsa00340 | 1.25894682 |
24 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.23664719 |
25 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.23467446 |
26 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.18643329 |
27 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.17799844 |
28 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.13518972 |
29 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.13390837 |
30 | Insulin resistance_Homo sapiens_hsa04931 | 1.13272682 |
31 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.12632996 |
32 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.11731860 |
33 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.08914571 |
34 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.07621169 |
35 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.07017743 |
36 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.01188199 |
37 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.01169795 |
38 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.00865493 |
39 | Insulin secretion_Homo sapiens_hsa04911 | 1.00495249 |
40 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.98341782 |
41 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.98249819 |
42 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.95695221 |
43 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.91432106 |
44 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.84852318 |
45 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.84427175 |
46 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.83870687 |
47 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.83858483 |
48 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.83506303 |
49 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.79314088 |
50 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.78874622 |
51 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.74053165 |
52 | Cocaine addiction_Homo sapiens_hsa05030 | 0.73341429 |
53 | Axon guidance_Homo sapiens_hsa04360 | 0.73318072 |
54 | Bladder cancer_Homo sapiens_hsa05219 | 0.71979825 |
55 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.70803185 |
56 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.69615259 |
57 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.69596424 |
58 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.69328767 |
59 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.69003912 |
60 | Retinol metabolism_Homo sapiens_hsa00830 | 0.67643387 |
61 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.67026122 |
62 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.65700485 |
63 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.63410508 |
64 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.63285399 |
65 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.62379012 |
66 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.61058718 |
67 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.60829326 |
68 | Lysosome_Homo sapiens_hsa04142 | 0.59076751 |
69 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.58234888 |
70 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.57619344 |
71 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.57362482 |
72 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.57242782 |
73 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.57107160 |
74 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.57033222 |
75 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.56857659 |
76 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.55717139 |
77 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.54154082 |
78 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.53430246 |
79 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.53340227 |
80 | Endocytosis_Homo sapiens_hsa04144 | 0.52281990 |
81 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.51471887 |
82 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.51389132 |
83 | Glioma_Homo sapiens_hsa05214 | 0.50860935 |
84 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.50075137 |
85 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.49738232 |
86 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.49086493 |
87 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.47774997 |
88 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.47551781 |
89 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.44934119 |
90 | Hepatitis C_Homo sapiens_hsa05160 | 0.44127876 |
91 | Melanogenesis_Homo sapiens_hsa04916 | 0.43913616 |
92 | Endometrial cancer_Homo sapiens_hsa05213 | 0.42799214 |
93 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.41900931 |
94 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.41109824 |
95 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.40640751 |
96 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.40604297 |
97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.38903205 |
98 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.38305099 |
99 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.36603537 |
100 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.33456077 |