ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.40966033
2	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.37619293
3	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.37619293
4	regulation of translation, ncRNA-mediated (GO:0045974)	4.37619293
5	interkinetic nuclear migration (GO:0022027)	4.11503067
6	regulation of gene silencing by RNA (GO:0060966)	3.90408849
7	regulation of posttranscriptional gene silencing (GO:0060147)	3.90408849
8	regulation of gene silencing by miRNA (GO:0060964)	3.90408849
9	indole-containing compound catabolic process (GO:0042436)	3.77654670
10	indolalkylamine catabolic process (GO:0046218)	3.77654670
11	tryptophan catabolic process (GO:0006569)	3.77654670
12	kynurenine metabolic process (GO:0070189)	3.76333372
13	regulation of hippo signaling (GO:0035330)	3.64593328
14	fucose catabolic process (GO:0019317)	3.62239616
15	L-fucose metabolic process (GO:0042354)	3.62239616
16	L-fucose catabolic process (GO:0042355)	3.62239616
17	indolalkylamine metabolic process (GO:0006586)	3.51541799
18	monoubiquitinated protein deubiquitination (GO:0035520)	3.42509591
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.39425272
20	gamma-aminobutyric acid transport (GO:0015812)	3.29958260
21	neural tube formation (GO:0001841)	3.27898329
22	tryptophan metabolic process (GO:0006568)	3.16769222
23	reflex (GO:0060004)	3.12576374
24	cilium or flagellum-dependent cell motility (GO:0001539)	3.11345940
25	protein K48-linked deubiquitination (GO:0071108)	3.11017560
26	positive regulation of CREB transcription factor activity (GO:0032793)	3.09512918
27	regulation of pigment cell differentiation (GO:0050932)	3.05908866
28	positive regulation of developmental pigmentation (GO:0048087)	3.05751225
29	cytoplasmic mRNA processing body assembly (GO:0033962)	3.03335287
30	cardiovascular system development (GO:0072358)	3.02461297
31	peristalsis (GO:0030432)	3.00574886
32	histone H3-K9 methylation (GO:0051567)	2.99527291
33	nephron tubule morphogenesis (GO:0072078)	2.98618989
34	nephron epithelium morphogenesis (GO:0072088)	2.98618989
35	neuronal action potential (GO:0019228)	2.97836605
36	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.96202035
37	primary amino compound metabolic process (GO:1901160)	2.94856208
38	serotonin metabolic process (GO:0042428)	2.94205901
39	postsynaptic membrane organization (GO:0001941)	2.91369460
40	snRNA transcription (GO:0009301)	2.91184779
41	kidney morphogenesis (GO:0060993)	2.91070595
42	spinal cord motor neuron differentiation (GO:0021522)	2.89467093
43	indole-containing compound metabolic process (GO:0042430)	2.88970540
44	detection of light stimulus involved in sensory perception (GO:0050962)	2.86955317
45	detection of light stimulus involved in visual perception (GO:0050908)	2.86955317
46	sulfation (GO:0051923)	2.80809977
47	negative regulation of sodium ion transport (GO:0010766)	2.80482121
48	cellular response to sterol (GO:0036315)	2.79172269
49	membrane depolarization during action potential (GO:0086010)	2.75665897
50	neuronal stem cell maintenance (GO:0097150)	2.75307901
51	cAMP catabolic process (GO:0006198)	2.74263173
52	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.73462718
53	behavioral response to ethanol (GO:0048149)	2.70333864
54	protein localization to synapse (GO:0035418)	2.68656725
55	nucleus localization (GO:0051647)	2.65435926
56	pyrimidine nucleobase catabolic process (GO:0006208)	2.65322876
57	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.62875362
58	cellular ketone body metabolic process (GO:0046950)	2.60657490
59	multicellular organismal movement (GO:0050879)	2.60588258
60	musculoskeletal movement (GO:0050881)	2.60588258
61	NAD biosynthetic process (GO:0009435)	2.58734180
62	regulation of establishment of cell polarity (GO:2000114)	2.58373240
63	rRNA catabolic process (GO:0016075)	2.57731084
64	transmission of nerve impulse (GO:0019226)	2.57357266
65	cellular response to cholesterol (GO:0071397)	2.55688834
66	presynaptic membrane assembly (GO:0097105)	2.55052178
67	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.53901761
68	urinary tract smooth muscle contraction (GO:0014848)	2.49185367
69	histone-serine phosphorylation (GO:0035404)	2.48634248
70	cornea development in camera-type eye (GO:0061303)	2.47883487
71	reciprocal DNA recombination (GO:0035825)	2.47592071
72	reciprocal meiotic recombination (GO:0007131)	2.47592071
73	startle response (GO:0001964)	2.47182174
74	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.46621590
75	protein import into peroxisome matrix (GO:0016558)	2.46259110
76	head development (GO:0060322)	2.46241241
77	appendage development (GO:0048736)	2.45035503
78	limb development (GO:0060173)	2.45035503
79	cyclic nucleotide catabolic process (GO:0009214)	2.44885214
80	inner ear receptor stereocilium organization (GO:0060122)	2.44364878
81	protein K11-linked deubiquitination (GO:0035871)	2.44306634
82	regulation of action potential (GO:0098900)	2.44072195
83	histone H3-K9 modification (GO:0061647)	2.42500310
84	histone H3-K4 trimethylation (GO:0080182)	2.39669760
85	cerebellar Purkinje cell differentiation (GO:0021702)	2.39064294
86	cell differentiation in spinal cord (GO:0021515)	2.38604988
87	neuron cell-cell adhesion (GO:0007158)	2.38473778
88	renal tubule morphogenesis (GO:0061333)	2.38458350
89	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.35788604
90	nonmotile primary cilium assembly (GO:0035058)	2.35780301
91	central nervous system neuron axonogenesis (GO:0021955)	2.34110639
92	regulation of telomere maintenance (GO:0032204)	2.32685143
93	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.32559324
94	neuron maturation (GO:0042551)	2.32434900
95	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.31516333
96	pericardium development (GO:0060039)	2.30971666
97	somite development (GO:0061053)	2.30947127
98	hindbrain development (GO:0030902)	2.30378861
99	regulation of sarcomere organization (GO:0060297)	2.29966113
100	amine catabolic process (GO:0009310)	2.28383416

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.52512138
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.29801970
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.12026033
4	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.10296113
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.07429365
6	VDR_22108803_ChIP-Seq_LS180_Human	2.80776929
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36888174
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21913890
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.18314708
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.17800411
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.16619426
12	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.15531852
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.08972790
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.05781244
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.03656268
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02595265
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92695216
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.92064170
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90388925
20	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.88927951
21	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88927951
22	EWS_26573619_Chip-Seq_HEK293_Human	1.87866269
23	* STAT3_23295773_ChIP-Seq_U87_Human	1.83119599
24	FUS_26573619_Chip-Seq_HEK293_Human	1.82614968
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80882252
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.79880410
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.77724327
28	P300_19829295_ChIP-Seq_ESCs_Human	1.77063023
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75174914
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.68683477
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.68002042
32	TCF4_23295773_ChIP-Seq_U87_Human	1.63882992
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60491141
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56000707
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.53198665
36	TP53_16413492_ChIP-PET_HCT116_Human	1.52432471
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49505211
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49076028
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45179984
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43731381
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.42447074
42	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.41905732
43	AR_25329375_ChIP-Seq_VCAP_Human	1.41138007
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.40203683
45	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.39835841
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.38934152
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.37447579
48	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.36988782
49	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.35489603
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33602211
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33133704
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.32830401
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.28872791
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28872791
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27971174
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26760831
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24896002
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23716752
59	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.21969807
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21687839
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21040586
62	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21002417
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20438299
64	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.19846932
65	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19627740
66	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.18970094
67	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18184023
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18099506
69	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.17848497
70	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.17101146
71	RXR_22108803_ChIP-Seq_LS180_Human	1.16053652
72	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.14969957
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14698564
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14641881
75	AHR_22903824_ChIP-Seq_MCF-7_Human	1.13525223
76	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13443696
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13419587
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.12164791
79	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11810636
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10534259
81	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.09521203
82	AR_19668381_ChIP-Seq_PC3_Human	1.08300550
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07256524
84	KDM2B_26808549_Chip-Seq_REH_Human	1.07039735
85	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.05842873
86	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.04169215
87	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03667418
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03637277
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00783002
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00343010
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99666855
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.99469438
93	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99269283
94	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.97822704
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97760998
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97551249
97	TP53_22573176_ChIP-Seq_HFKS_Human	0.97423662
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97235101
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96983310
100	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.96852506

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.37438074
2	MP0003136_yellow_coat_color	3.07432006
3	MP0008057_abnormal_DNA_replication	2.62817858
4	MP0003195_calcinosis	2.55114233
5	MP0003646_muscle_fatigue	2.39580311
6	MP0009046_muscle_twitch	2.36908675
7	MP0008877_abnormal_DNA_methylation	2.26161935
8	MP0003890_abnormal_embryonic-extraembry	2.16239509
9	MP0009745_abnormal_behavioral_response	2.01801304
10	MP0005551_abnormal_eye_electrophysiolog	2.01364620
11	MP0004043_abnormal_pH_regulation	1.87288675
12	MP0001486_abnormal_startle_reflex	1.86065542
13	MP0000778_abnormal_nervous_system	1.84047719
14	MP0001968_abnormal_touch/_nociception	1.83620414
15	MP0004142_abnormal_muscle_tone	1.82001862
16	MP0004145_abnormal_muscle_electrophysio	1.79525754
17	MP0002735_abnormal_chemical_nociception	1.78788967
18	MP0002638_abnormal_pupillary_reflex	1.76614735
19	MP0005174_abnormal_tail_pigmentation	1.75235646
20	MP0001485_abnormal_pinna_reflex	1.75179928
21	MP0000631_abnormal_neuroendocrine_gland	1.72212943
22	MP0001501_abnormal_sleep_pattern	1.71704108
23	MP0002938_white_spotting	1.70222049
24	MP0004885_abnormal_endolymph	1.66809522
25	MP0004130_abnormal_muscle_cell	1.66735639
26	MP0002102_abnormal_ear_morphology	1.63997426
27	MP0004133_heterotaxia	1.63084441
28	MP0005377_hearing/vestibular/ear_phenot	1.60507045
29	MP0003878_abnormal_ear_physiology	1.60507045
30	MP0004742_abnormal_vestibular_system	1.58331469
31	MP0002064_seizures	1.58274163
32	MP0006276_abnormal_autonomic_nervous	1.58218506
33	MP0003787_abnormal_imprinting	1.57891735
34	MP0003635_abnormal_synaptic_transmissio	1.57653683
35	MP0006292_abnormal_olfactory_placode	1.57116689
36	MP0002063_abnormal_learning/memory/cond	1.54199372
37	MP0002572_abnormal_emotion/affect_behav	1.53603640
38	MP0001986_abnormal_taste_sensitivity	1.52988976
39	MP0002272_abnormal_nervous_system	1.52530859
40	MP0005171_absent_coat_pigmentation	1.48988450
41	MP0002067_abnormal_sensory_capabilities	1.48956061
42	MP0002653_abnormal_ependyma_morphology	1.45701392
43	MP0000427_abnormal_hair_cycle	1.42077366
44	MP0002928_abnormal_bile_duct	1.41415666
45	MP0002557_abnormal_social/conspecific_i	1.39551650
46	MP0005386_behavior/neurological_phenoty	1.38274866
47	MP0004924_abnormal_behavior	1.38274866
48	MP0000383_abnormal_hair_follicle	1.37164547
49	MP0008872_abnormal_physiological_respon	1.37145937
50	MP0005253_abnormal_eye_physiology	1.35994132
51	MP0003937_abnormal_limbs/digits/tail_de	1.35761532
52	MP0005645_abnormal_hypothalamus_physiol	1.35170025
53	MP0002736_abnormal_nociception_after	1.26899950
54	MP0003119_abnormal_digestive_system	1.26226038
55	MP0001970_abnormal_pain_threshold	1.23131628
56	MP0002733_abnormal_thermal_nociception	1.22195205
57	MP0008961_abnormal_basal_metabolism	1.21952450
58	MP0002734_abnormal_mechanical_nocicepti	1.16956848
59	MP0002009_preneoplasia	1.13275844
60	MP0005423_abnormal_somatic_nervous	1.11469508
61	MP0005646_abnormal_pituitary_gland	1.11417569
62	MP0000955_abnormal_spinal_cord	1.10859546
63	MP0000566_synostosis	1.08221968
64	MP0002184_abnormal_innervation	1.07790038
65	MP0006072_abnormal_retinal_apoptosis	1.07721798
66	MP0004147_increased_porphyrin_level	1.07152546
67	MP0000026_abnormal_inner_ear	1.06713959
68	MP0002752_abnormal_somatic_nervous	1.04042085
69	MP0002882_abnormal_neuron_morphology	1.03644389
70	MP0003632_abnormal_nervous_system	1.01499360
71	MP0003880_abnormal_central_pattern	0.97981538
72	MP0005195_abnormal_posterior_eye	0.97122005
73	MP0002152_abnormal_brain_morphology	0.96111054
74	MP0005187_abnormal_penis_morphology	0.93165134
75	MP0003045_fibrosis	0.92583689
76	MP0003121_genomic_imprinting	0.92031173
77	MP0003861_abnormal_nervous_system	0.91845238
78	MP0003137_abnormal_impulse_conducting	0.90215372
79	MP0001440_abnormal_grooming_behavior	0.89245737
80	MP0002837_dystrophic_cardiac_calcinosis	0.87581358
81	MP0003938_abnormal_ear_development	0.85632731
82	MP0002876_abnormal_thyroid_physiology	0.85180388
83	MP0002160_abnormal_reproductive_system	0.84255737
84	MP0002095_abnormal_skin_pigmentation	0.83638375
85	MP0001963_abnormal_hearing_physiology	0.82454845
86	MP0003283_abnormal_digestive_organ	0.81230497
87	MP0001502_abnormal_circadian_rhythm	0.79944318
88	MP0003698_abnormal_male_reproductive	0.79622781
89	MP0001324_abnormal_eye_pigmentation	0.78406431
90	MP0002751_abnormal_autonomic_nervous	0.77668980
91	MP0001293_anophthalmia	0.76926909
92	MP0004215_abnormal_myocardial_fiber	0.75762100
93	MP0005167_abnormal_blood-brain_barrier	0.75360061
94	MP0005391_vision/eye_phenotype	0.74878999
95	MP0002229_neurodegeneration	0.74340433
96	MP0000230_abnormal_systemic_arterial	0.73318986
97	MP0003122_maternal_imprinting	0.71844486
98	MP0003631_nervous_system_phenotype	0.70351873
99	MP0001984_abnormal_olfaction	0.68909022
100	MP0000538_abnormal_urinary_bladder	0.68746235

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.85047081
2	Hyperventilation (HP:0002883)	4.38191412
3	Pancreatic cysts (HP:0001737)	4.17704914
4	Birth length less than 3rd percentile (HP:0003561)	3.84009007
5	Pancreatic fibrosis (HP:0100732)	3.77380956
6	Progressive cerebellar ataxia (HP:0002073)	3.76209068
7	Protruding tongue (HP:0010808)	3.66751538
8	Molar tooth sign on MRI (HP:0002419)	3.52740556
9	Abnormality of midbrain morphology (HP:0002418)	3.52740556
10	True hermaphroditism (HP:0010459)	3.50680163
11	Nephronophthisis (HP:0000090)	3.32957579
12	Congenital stationary night blindness (HP:0007642)	3.24793272
13	Patellar aplasia (HP:0006443)	3.23275774
14	Gaze-evoked nystagmus (HP:0000640)	3.15589436
15	Abnormality of the renal medulla (HP:0100957)	3.06612864
16	Clumsiness (HP:0002312)	3.04894622
17	Aplasia/Hypoplasia of the patella (HP:0006498)	2.94752488
18	Chronic hepatic failure (HP:0100626)	2.87310627
19	Cystic liver disease (HP:0006706)	2.85369611
20	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.83597170
21	Hypoplastic ischia (HP:0003175)	2.82160806
22	Abnormality of the ischium (HP:0003174)	2.70865802
23	Broad-based gait (HP:0002136)	2.70301276
24	Attenuation of retinal blood vessels (HP:0007843)	2.67031714
25	Abnormality of the renal cortex (HP:0011035)	2.66541457
26	Inability to walk (HP:0002540)	2.63678321
27	Large for gestational age (HP:0001520)	2.62858693
28	Type II lissencephaly (HP:0007260)	2.60447360
29	Cerebellar dysplasia (HP:0007033)	2.59012645
30	Febrile seizures (HP:0002373)	2.53512846
31	Fair hair (HP:0002286)	2.52777769
32	Tubular atrophy (HP:0000092)	2.49666953
33	Partial agenesis of the corpus callosum (HP:0001338)	2.43560930
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.39865916
35	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.33707232
36	Absent speech (HP:0001344)	2.23109474
37	Abnormality of alanine metabolism (HP:0010916)	2.18739111
38	Hyperalaninemia (HP:0003348)	2.18739111
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18739111
40	Furrowed tongue (HP:0000221)	2.18380395
41	Abnormality of the pubic bones (HP:0003172)	2.16946651
42	Lissencephaly (HP:0001339)	2.13082618
43	Chorioretinal atrophy (HP:0000533)	2.11047103
44	Progressive inability to walk (HP:0002505)	2.10914344
45	Drooling (HP:0002307)	2.08399515
46	Medial flaring of the eyebrow (HP:0010747)	2.04502835
47	Anencephaly (HP:0002323)	2.03810372
48	Sclerocornea (HP:0000647)	2.03547435
49	Widely spaced teeth (HP:0000687)	2.02816931
50	Hypoplastic labia majora (HP:0000059)	2.02681798
51	Abnormal drinking behavior (HP:0030082)	2.01562181
52	Polydipsia (HP:0001959)	2.01562181
53	Generalized hypopigmentation of hair (HP:0011358)	2.01419522
54	Preaxial foot polydactyly (HP:0001841)	1.99052960
55	Abnormality of the labia majora (HP:0012881)	1.98023806
56	Breast hypoplasia (HP:0003187)	1.97854117
57	Highly arched eyebrow (HP:0002553)	1.97768734
58	Abnormality of the pons (HP:0007361)	1.96813860
59	Focal seizures (HP:0007359)	1.96153742
60	Congenital hepatic fibrosis (HP:0002612)	1.95882276
61	Bony spicule pigmentary retinopathy (HP:0007737)	1.95812781
62	Short 4th metacarpal (HP:0010044)	1.95639579
63	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.95639579
64	Duplicated collecting system (HP:0000081)	1.94890961
65	Tracheomalacia (HP:0002779)	1.92667827
66	Urinary bladder sphincter dysfunction (HP:0002839)	1.92639297
67	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91828732
68	Pendular nystagmus (HP:0012043)	1.90921914
69	Increased corneal curvature (HP:0100692)	1.90896011
70	Keratoconus (HP:0000563)	1.90896011
71	Abnormality of the renal collecting system (HP:0004742)	1.90520286
72	Hypoplasia of the pons (HP:0012110)	1.90050305
73	Small hand (HP:0200055)	1.88937372
74	Decreased circulating renin level (HP:0003351)	1.86320064
75	Excessive salivation (HP:0003781)	1.86206091
76	Focal motor seizures (HP:0011153)	1.86106098
77	Gait imbalance (HP:0002141)	1.85072906
78	Absent/shortened dynein arms (HP:0200106)	1.83201642
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.83201642
80	Concave nail (HP:0001598)	1.80655277
81	Bronchomalacia (HP:0002780)	1.79929346
82	Stomach cancer (HP:0012126)	1.79481495
83	Hypoplastic iliac wings (HP:0002866)	1.77457523
84	Ectopic kidney (HP:0000086)	1.76671595
85	Poor coordination (HP:0002370)	1.76215435
86	Dysmetric saccades (HP:0000641)	1.73236919
87	Bile duct proliferation (HP:0001408)	1.73009626
88	Abnormal biliary tract physiology (HP:0012439)	1.73009626
89	Abolished electroretinogram (ERG) (HP:0000550)	1.72224439
90	Oligodactyly (hands) (HP:0001180)	1.70286869
91	Dialeptic seizures (HP:0011146)	1.69990981
92	Midline defect of the nose (HP:0004122)	1.69743150
93	Short foot (HP:0001773)	1.69694372
94	Hemiparesis (HP:0001269)	1.69574591
95	Acute lymphatic leukemia (HP:0006721)	1.68872787
96	Congenital, generalized hypertrichosis (HP:0004540)	1.68236428
97	Genital tract atresia (HP:0001827)	1.67361121
98	Bilateral microphthalmos (HP:0007633)	1.67062044
99	Diplopia (HP:0000651)	1.66589397
100	Abnormality of binocular vision (HP:0011514)	1.66589397

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.36780192
2	ACVR1B	3.40282489
3	BMPR1B	3.39470134
4	ADRBK2	2.56172670
5	PNCK	2.48052399
6	CASK	2.31468340
7	NTRK3	2.18599808
8	MARK1	1.98430637
9	MKNK2	1.97527190
10	ZAK	1.87790323
11	INSRR	1.83072961
12	MAPK13	1.81368092
13	WNK4	1.76022012
14	WNK3	1.75105441
15	CAMK1D	1.72645063
16	CAMK1G	1.70172370
17	SIK2	1.55570276
18	TLK1	1.55286894
19	TAOK3	1.52500748
20	TNIK	1.51736683
21	GRK1	1.49746533
22	TGFBR1	1.42613050
23	MAPK15	1.38601864
24	MAP3K4	1.34198946
25	AKT3	1.33919088
26	DAPK2	1.32318046
27	LATS1	1.23085839
28	PINK1	1.20451776
29	WNK1	1.18696841
30	CDK12	1.18241780
31	NTRK2	1.16534381
32	TYRO3	1.15268172
33	SGK2	1.12582661
34	NEK2	1.10881419
35	ADRBK1	1.07503946
36	STK38L	1.03149434
37	FGFR2	0.98677768
38	OXSR1	0.96580354
39	NUAK1	0.94728431
40	MKNK1	0.94189179
41	PIK3CA	0.94176777
42	WEE1	0.88487238
43	SGK223	0.87754722
44	SGK494	0.87754722
45	NLK	0.86879851
46	MAP3K7	0.84314206
47	CAMKK2	0.84061535
48	BRD4	0.81722566
49	BRSK2	0.79415549
50	STK39	0.77299330
51	CAMK4	0.72484598
52	EEF2K	0.71906799
53	STK11	0.71524724
54	PAK3	0.71001697
55	DYRK2	0.70986968
56	OBSCN	0.68740160
57	PRKCG	0.68380109
58	MELK	0.68032019
59	MAPKAPK5	0.65447221
60	TRPM7	0.65364637
61	PIK3CG	0.64052175
62	PRKAA2	0.61581649
63	PRKAA1	0.61429613
64	CAMK1	0.61328383
65	CAMKK1	0.61256847
66	PTK2B	0.59272247
67	CHEK2	0.57192730
68	EPHA3	0.56638723
69	RPS6KA6	0.56517004
70	MAP4K2	0.51895834
71	ERBB2	0.51817745
72	SGK1	0.51138403
73	TEC	0.50816293
74	DYRK1A	0.48830815
75	MAP2K1	0.48100627
76	MARK2	0.45698816
77	PKN1	0.44811769
78	CSNK1D	0.43939340
79	PRKCH	0.43177551
80	CHUK	0.41077027
81	STK3	0.41046024
82	MAP2K4	0.40721616
83	CDK3	0.40528196
84	MAPKAPK3	0.40459191
85	PRKCE	0.40408609
86	ATR	0.40392720
87	RET	0.39103978
88	CAMK2A	0.39021895
89	EPHA4	0.37763739
90	SGK3	0.36178098
91	MAP3K2	0.35140074
92	KIT	0.34775111
93	GSK3B	0.34683238
94	RPS6KA5	0.34312900
95	IRAK1	0.33893398
96	MAP2K6	0.33315641
97	TNK2	0.33145046
98	MAP2K7	0.32859899
99	AKT1	0.32851391
100	ATM	0.32711464

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.12173355
2	Phototransduction_Homo sapiens_hsa04744	2.64697392
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.57784549
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.47526954
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.44731735
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.30716010
7	Butanoate metabolism_Homo sapiens_hsa00650	2.18773893
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.13393329
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00889873
10	Morphine addiction_Homo sapiens_hsa05032	1.99268965
11	Taste transduction_Homo sapiens_hsa04742	1.97991515
12	ABC transporters_Homo sapiens_hsa02010	1.95401865
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91033571
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.80156560
15	Circadian entrainment_Homo sapiens_hsa04713	1.74984975
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.73299643
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.62191090
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.59373114
19	Olfactory transduction_Homo sapiens_hsa04740	1.57087317
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.52514952
21	Lysine degradation_Homo sapiens_hsa00310	1.51883607
22	GABAergic synapse_Homo sapiens_hsa04727	1.46831504
23	Serotonergic synapse_Homo sapiens_hsa04726	1.46069872
24	Homologous recombination_Homo sapiens_hsa03440	1.43956687
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.43128740
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.42259369
27	Cholinergic synapse_Homo sapiens_hsa04725	1.41560630
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37919858
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.34022592
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32873003
31	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.31718139
32	Insulin secretion_Homo sapiens_hsa04911	1.24877908
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.24162883
34	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.18264236
35	Long-term depression_Homo sapiens_hsa04730	1.17953001
36	Cocaine addiction_Homo sapiens_hsa05030	1.16847823
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16558712
38	Basal cell carcinoma_Homo sapiens_hsa05217	1.12911882
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08009937
40	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.06283591
41	Dopaminergic synapse_Homo sapiens_hsa04728	1.03745509
42	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.01768613
43	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99867990
44	Gastric acid secretion_Homo sapiens_hsa04971	0.99118550
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.95435202
46	Salivary secretion_Homo sapiens_hsa04970	0.94110851
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.93640987
48	Type II diabetes mellitus_Homo sapiens_hsa04930	0.92813605
49	Basal transcription factors_Homo sapiens_hsa03022	0.88676694
50	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.88247306
51	Histidine metabolism_Homo sapiens_hsa00340	0.86167766
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85356462
53	Axon guidance_Homo sapiens_hsa04360	0.84437053
54	Amphetamine addiction_Homo sapiens_hsa05031	0.82144589
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80958897
56	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.77306656
57	Circadian rhythm_Homo sapiens_hsa04710	0.74778674
58	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.72769365
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.70422222
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70286250
61	One carbon pool by folate_Homo sapiens_hsa00670	0.69831175
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.67999952
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.66583450
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63694765
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63628699
66	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.62167582
67	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.60538777
68	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60437643
69	Estrogen signaling pathway_Homo sapiens_hsa04915	0.56122739
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55996897
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.55550308
72	Ras signaling pathway_Homo sapiens_hsa04014	0.55021752
73	Bile secretion_Homo sapiens_hsa04976	0.55017375
74	Caffeine metabolism_Homo sapiens_hsa00232	0.54245050
75	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.54046852
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54046666
77	Retinol metabolism_Homo sapiens_hsa00830	0.52962534
78	Renin secretion_Homo sapiens_hsa04924	0.51032153
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48973284
80	Melanogenesis_Homo sapiens_hsa04916	0.48715696
81	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.48636019
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48381289
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.48342259
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46603183
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46399696
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.44632192
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.43441243
88	Melanoma_Homo sapiens_hsa05218	0.42634222
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.42505782
90	Cardiac muscle contraction_Homo sapiens_hsa04260	0.41536801
91	Pancreatic secretion_Homo sapiens_hsa04972	0.40151981
92	Platelet activation_Homo sapiens_hsa04611	0.39757909
93	RNA degradation_Homo sapiens_hsa03018	0.39356323
94	Choline metabolism in cancer_Homo sapiens_hsa05231	0.38166159
95	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.37393282
96	Wnt signaling pathway_Homo sapiens_hsa04310	0.36377715
97	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.36213290
98	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.35948963
99	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.35857790
100	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.35242430

ZNF445

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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