ZNF446

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)9.33352670
2negative regulation of cell aging (GO:0090344)9.30523400
3GDP-mannose metabolic process (GO:0019673)8.93781050
4regulation of skeletal muscle contraction (GO:0014819)8.79825117
5DNA strand renaturation (GO:0000733)8.77909362
6regulation of synapse structural plasticity (GO:0051823)8.17833096
7adenosine receptor signaling pathway (GO:0001973)7.88963022
8protein carboxylation (GO:0018214)7.29645001
9peptidyl-glutamic acid carboxylation (GO:0017187)7.29645001
10meiotic chromosome segregation (GO:0045132)7.12203504
11mitotic cell cycle arrest (GO:0071850)6.99079341
12lens fiber cell differentiation (GO:0070306)6.93782557
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.84285383
14purinergic nucleotide receptor signaling pathway (GO:0035590)6.47390033
15negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.39463943
16regulation of cytokine production involved in inflammatory response (GO:1900015)6.14527593
17positive regulation of protein kinase C signaling (GO:0090037)5.99551963
18transepithelial transport (GO:0070633)5.49463432
19adenine nucleotide transport (GO:0051503)5.47186879
20rRNA methylation (GO:0031167)5.40591014
21purine ribonucleotide transport (GO:0015868)5.26919917
22detection of light stimulus involved in visual perception (GO:0050908)5.24763882
23detection of light stimulus involved in sensory perception (GO:0050962)5.24763882
24sensory perception of taste (GO:0050909)5.23974071
25urinary tract smooth muscle contraction (GO:0014848)5.11837353
26response to ATP (GO:0033198)5.11294590
27purinergic receptor signaling pathway (GO:0035587)4.83563772
28behavioral response to nicotine (GO:0035095)4.63003305
29UV protection (GO:0009650)4.62781940
30phosphatidylglycerol biosynthetic process (GO:0006655)4.62339827
31estrogen biosynthetic process (GO:0006703)4.62231614
32positive regulation of heat generation (GO:0031652)4.61452748
33rRNA modification (GO:0000154)4.59646504
34nucleotide transmembrane transport (GO:1901679)4.50713838
35granulocyte differentiation (GO:0030851)4.38319343
36melanin biosynthetic process (GO:0042438)4.36536543
37nucleoside transmembrane transport (GO:1901642)4.33833781
38cilium or flagellum-dependent cell motility (GO:0001539)4.32201131
39G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.24710235
40regulation of cell aging (GO:0090342)4.20173265
41regulation of protein kinase A signaling (GO:0010738)4.20151288
42purine nucleotide transport (GO:0015865)4.15979197
43sulfur amino acid catabolic process (GO:0000098)4.05382165
44sex determination (GO:0007530)4.03132866
45semaphorin-plexin signaling pathway (GO:0071526)4.00831520
46sphingomyelin metabolic process (GO:0006684)3.98249451
47mannose metabolic process (GO:0006013)3.97916583
48melanin metabolic process (GO:0006582)3.96710252
49peristalsis (GO:0030432)3.91278934
50cell migration in hindbrain (GO:0021535)3.89096489
51negative regulation of interleukin-8 production (GO:0032717)3.89030166
52protein insertion into membrane (GO:0051205)3.87982860
53regulation of phospholipid biosynthetic process (GO:0071071)3.82728138
54sialylation (GO:0097503)3.75513785
55nucleotide-sugar biosynthetic process (GO:0009226)3.67469067
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.62412020
57neuromuscular synaptic transmission (GO:0007274)3.57878812
58base-excision repair, AP site formation (GO:0006285)3.55398355
59grooming behavior (GO:0007625)3.51770241
60cellular anion homeostasis (GO:0030002)3.48486784
61type B pancreatic cell proliferation (GO:0044342)3.46737546
62secondary metabolite biosynthetic process (GO:0044550)3.45721156
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.45515751
64peptidyl-glutamic acid modification (GO:0018200)3.43464762
65cardiolipin metabolic process (GO:0032048)3.39496519
66ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.36223375
67nucleoside bisphosphate biosynthetic process (GO:0033866)3.36223375
68purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.36223375
69purine deoxyribonucleotide catabolic process (GO:0009155)3.35876104
70folic acid metabolic process (GO:0046655)3.35622090
71regulation of heat generation (GO:0031650)3.33186673
72sphingosine metabolic process (GO:0006670)3.27889689
73gonadal mesoderm development (GO:0007506)3.25486382
74trivalent inorganic anion homeostasis (GO:0072506)3.25310144
75phosphate ion homeostasis (GO:0055062)3.25310144
76endocytic recycling (GO:0032456)3.22273803
77DNA replication checkpoint (GO:0000076)3.21584423
78phosphatidylethanolamine biosynthetic process (GO:0006646)3.18905922
793-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.18414422
80purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.18414422
81diol metabolic process (GO:0034311)3.16706796
82histone phosphorylation (GO:0016572)3.10903408
83nucleoside transport (GO:0015858)3.09352375
84mitochondrion distribution (GO:0048311)3.07733747
85folic acid transport (GO:0015884)3.06645628
86tRNA modification (GO:0006400)3.06138367
87protein import into peroxisome matrix (GO:0016558)3.02079437
88activation of adenylate cyclase activity (GO:0007190)3.01461110
89dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.96052061
90proline biosynthetic process (GO:0006561)2.91083469
91phosphatidylethanolamine metabolic process (GO:0046337)2.89421831
92negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.88549161
93DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.84074207
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.79702792
95phosphate ion transmembrane transport (GO:0035435)2.78990123
96iron coordination entity transport (GO:1901678)2.75775851
97regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.70215663
98muscle fiber development (GO:0048747)2.68483665
99response to gravity (GO:0009629)2.65868186
100regulation of hydrogen peroxide metabolic process (GO:0010310)2.65033092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.40378811
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.67572049
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.28274436
4P68_20966046_ChIP-Seq_HELA_Human3.10965635
5LXR_22292898_ChIP-Seq_THP-1_Human3.08988282
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.83535514
7XRN2_22483619_ChIP-Seq_HELA_Human2.63989375
8MAF_26560356_Chip-Seq_TH2_Human2.56418143
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40261955
10BCL6_27268052_Chip-Seq_Bcells_Human2.34934014
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.32810105
12E2F1_20622854_ChIP-Seq_HELA_Human2.32564969
13BCOR_27268052_Chip-Seq_Bcells_Human2.32540416
14CTCF_27219007_Chip-Seq_Bcells_Human2.29694539
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28518279
16RACK7_27058665_Chip-Seq_MCF-7_Human2.24591350
17MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.19907483
18* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.17163692
19PHF8_20622854_ChIP-Seq_HELA_Human2.13474373
20CTCF_27219007_Chip-Seq_ERYTHROID_Human2.13433262
21TET1_21451524_ChIP-Seq_MESCs_Mouse2.13423960
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07314214
23VDR_24763502_ChIP-Seq_THP-1_Human2.04917886
24MAF_26560356_Chip-Seq_TH1_Human2.03442503
25RARB_24833708_ChIP-Seq_LIVER_Mouse1.99909159
26SMC4_20622854_ChIP-Seq_HELA_Human1.93332092
27SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.92356408
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91828957
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89456101
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88184675
31RARA_24833708_ChIP-Seq_LIVER_Mouse1.86995603
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.85879389
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.84489291
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.82886170
35FOXP1_21924763_ChIP-Seq_HESCs_Human1.82500957
36SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.82275456
37* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.81425921
38MYC_22102868_ChIP-Seq_BL_Human1.78887177
39KDM2B_26808549_Chip-Seq_DND41_Human1.78756767
40RXRA_24833708_ChIP-Seq_LIVER_Mouse1.77599809
41SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.75127957
42CTCF_21964334_Chip-Seq_Bcells_Human1.74652691
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70361501
44UTX_26944678_Chip-Seq_JUKART_Human1.65885037
45CREB1_26743006_Chip-Seq_LNCaP_Human1.63250888
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61974242
47YY1_22570637_ChIP-Seq_MALME-3M_Human1.58925677
48* CTCF_20526341_ChIP-Seq_ESCs_Human1.58538812
49SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55976645
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54569271
51CTCF_21964334_ChIP-Seq_BJAB-B_Human1.54477792
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53205619
53TP53_22127205_ChIP-Seq_IMR90_Human1.53040342
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48701352
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.47597699
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46232623
57TCF7_22412390_ChIP-Seq_EML_Mouse1.46214426
58CIITA_25753668_ChIP-Seq_RAJI_Human1.44941587
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44718395
60SA1_27219007_Chip-Seq_Bcells_Human1.44331223
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43591881
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41200692
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40647579
64ETS1_21867929_ChIP-Seq_TH2_Mouse1.37964904
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35451214
66ERA_21632823_ChIP-Seq_H3396_Human1.34133800
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32581267
68FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30833995
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30372154
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29059894
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28199588
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22136140
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.19399335
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.16978014
75JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.16679393
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15128395
77GABP_19822575_ChIP-Seq_HepG2_Human1.13584746
78KDM2B_26808549_Chip-Seq_K562_Human1.12948234
79TP63_22573176_ChIP-Seq_HFKS_Human1.12629522
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.10269587
81NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.07725381
82SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06987605
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06879227
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06745188
85* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06219427
86* ATF3_27146783_Chip-Seq_COLON_Human1.06073840
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04967847
88DCP1A_22483619_ChIP-Seq_HELA_Human1.04509639
89* P300_27268052_Chip-Seq_Bcells_Human1.04071150
90SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02509272
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01023564
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99692545
93* OCT4_19829295_ChIP-Seq_ESCs_Human0.98677128
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98361396
95ESR2_21235772_ChIP-Seq_MCF-7_Human0.98100044
96* RUNX1_27514584_Chip-Seq_MCF-7_Human0.97585266
97OCT4_20526341_ChIP-Seq_ESCs_Human0.97199083
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.96756221
99P53_21459846_ChIP-Seq_SAOS-2_Human0.95744726
100* NCOR1_26117541_ChIP-Seq_K562_Human0.95675241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.64378035
2MP0001986_abnormal_taste_sensitivity6.38860748
3MP0005423_abnormal_somatic_nervous6.16151109
4MP0005174_abnormal_tail_pigmentation5.78811794
5MP0003136_yellow_coat_color5.29998009
6MP0001188_hyperpigmentation3.51079070
7MP0005409_darkened_coat_color3.41654673
8MP0001968_abnormal_touch/_nociception3.07276906
9MP0005083_abnormal_biliary_tract2.92449588
10MP0008875_abnormal_xenobiotic_pharmacok2.90989854
11MP0000751_myopathy2.89926845
12MP0001502_abnormal_circadian_rhythm2.45246409
13MP0002736_abnormal_nociception_after2.31321101
14MP0001756_abnormal_urination2.28971840
15MP0004381_abnormal_hair_follicle2.25354022
16MP0002638_abnormal_pupillary_reflex2.23604416
17MP0001661_extended_life_span2.08882457
18MP0000750_abnormal_muscle_regeneration1.99385400
19MP0000015_abnormal_ear_pigmentation1.99008716
20MP0002735_abnormal_chemical_nociception1.78137243
21MP0003453_abnormal_keratinocyte_physiol1.73874971
22MP0000538_abnormal_urinary_bladder1.66037946
23MP0002160_abnormal_reproductive_system1.65893258
24MP0005330_cardiomyopathy1.61704325
25MP0000013_abnormal_adipose_tissue1.58829426
26MP0004130_abnormal_muscle_cell1.55467403
27MP0005332_abnormal_amino_acid1.24460587
28MP0003111_abnormal_nucleus_morphology1.19404848
29MP0005501_abnormal_skin_physiology1.16936496
30MP0005551_abnormal_eye_electrophysiolog1.13733684
31MP0005410_abnormal_fertilization1.13633764
32MP0005365_abnormal_bile_salt1.13082757
33MP0003705_abnormal_hypodermis_morpholog1.09414923
34MP0001765_abnormal_ion_homeostasis1.06507851
35MP0000747_muscle_weakness1.05870961
36MP0005076_abnormal_cell_differentiation1.05313212
37MP0004043_abnormal_pH_regulation1.04573495
38MP0005058_abnormal_lysosome_morphology1.03838274
39MP0003878_abnormal_ear_physiology1.03815352
40MP0005377_hearing/vestibular/ear_phenot1.03815352
41MP0000003_abnormal_adipose_tissue1.01077752
42MP0001919_abnormal_reproductive_system0.95959512
43MP0001958_emphysema0.90933625
44MP0001664_abnormal_digestion0.90057885
45MP0005584_abnormal_enzyme/coenzyme_acti0.89221165
46MP0002909_abnormal_adrenal_gland0.88343140
47MP0003137_abnormal_impulse_conducting0.88160898
48MP0009278_abnormal_bone_marrow0.84582043
49MP0001905_abnormal_dopamine_level0.83710167
50MP0005084_abnormal_gallbladder_morpholo0.82935916
51MP0001970_abnormal_pain_threshold0.81940954
52MP0000470_abnormal_stomach_morphology0.79930417
53MP0004019_abnormal_vitamin_homeostasis0.77875475
54MP0010386_abnormal_urinary_bladder0.75785080
55MP0001348_abnormal_lacrimal_gland0.74893698
56MP0000367_abnormal_coat/_hair0.71749808
57MP0000358_abnormal_cell_content/0.71559369
58MP0001346_abnormal_lacrimal_gland0.71486003
59MP0001324_abnormal_eye_pigmentation0.70078184
60MP0003806_abnormal_nucleotide_metabolis0.69205798
61MP0009840_abnormal_foam_cell0.65964296
62MP0003077_abnormal_cell_cycle0.65757475
63MP0005257_abnormal_intraocular_pressure0.65530831
64MP0002928_abnormal_bile_duct0.65332704
65MP0002254_reproductive_system_inflammat0.64413990
66MP0009643_abnormal_urine_homeostasis0.63427329
67MP0003303_peritoneal_inflammation0.61349494
68MP0003448_altered_tumor_morphology0.59794605
69MP0009931_abnormal_skin_appearance0.59592236
70MP0010771_integument_phenotype0.59087606
71MP0005389_reproductive_system_phenotype0.58533619
72MP0003091_abnormal_cell_migration0.58387728
73MP0005253_abnormal_eye_physiology0.56992885
74MP0004197_abnormal_fetal_growth/weight/0.53410438
75MP0002210_abnormal_sex_determination0.52356751
76MP0002249_abnormal_larynx_morphology0.51743533
77MP0002019_abnormal_tumor_incidence0.50001068
78MP0002075_abnormal_coat/hair_pigmentati0.49922686
79MP0002933_joint_inflammation0.49539887
80MP0001873_stomach_inflammation0.49527075
81MP0003635_abnormal_synaptic_transmissio0.47449304
82MP0005220_abnormal_exocrine_pancreas0.46966347
83MP0003329_amyloid_beta_deposits0.43803094
84MP0002136_abnormal_kidney_physiology0.42859347
85MP0004215_abnormal_myocardial_fiber0.41351424
86MP0003693_abnormal_embryo_hatching0.41346480
87MP0008874_decreased_physiological_sensi0.40450729
88MP0003172_abnormal_lysosome_physiology0.39651318
89MP0000778_abnormal_nervous_system0.39494089
90MP0000026_abnormal_inner_ear0.39125884
91MP0002118_abnormal_lipid_homeostasis0.37127056
92MP0003698_abnormal_male_reproductive0.36947675
93MP0002063_abnormal_learning/memory/cond0.36876467
94MP0005375_adipose_tissue_phenotype0.36847258
95MP0008770_decreased_survivor_rate0.36756234
96MP0001270_distended_abdomen0.36218072
97MP0000678_abnormal_parathyroid_gland0.35518217
98MP0003632_abnormal_nervous_system0.35381277
99MP0001191_abnormal_skin_condition0.33427191
100MP0004185_abnormal_adipocyte_glucose0.33322711

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)6.78786335
2Testicular atrophy (HP:0000029)6.75698659
3Attenuation of retinal blood vessels (HP:0007843)5.29247309
4Rectal fistula (HP:0100590)5.22648506
5Rectovaginal fistula (HP:0000143)5.22648506
6Thin bony cortex (HP:0002753)5.16683366
7Dyschromatopsia (HP:0007641)5.13926283
8Poikiloderma (HP:0001029)5.04800515
9Annular pancreas (HP:0001734)4.95157245
10Intestinal fistula (HP:0100819)4.91182545
11Vaginal fistula (HP:0004320)4.86990816
12Ulnar bowing (HP:0003031)4.73431306
13Facial hemangioma (HP:0000329)4.72461025
14Mesangial abnormality (HP:0001966)4.68781374
15Turricephaly (HP:0000262)4.58096919
16Akinesia (HP:0002304)4.56040477
17Abnormality of the intrinsic pathway (HP:0010989)4.42408967
18Popliteal pterygium (HP:0009756)4.38219962
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.25627365
20Facial diplegia (HP:0001349)4.16055391
21Hemorrhage of the eye (HP:0011885)4.10621250
22Joint hemorrhage (HP:0005261)4.03805285
23Congenital stationary night blindness (HP:0007642)3.98170091
24Aplasia of the musculature (HP:0100854)3.95659584
25Prolonged partial thromboplastin time (HP:0003645)3.93137966
26Fetal akinesia sequence (HP:0001989)3.92554763
27Coronal craniosynostosis (HP:0004440)3.92272968
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.88256829
29Delayed epiphyseal ossification (HP:0002663)3.68600372
30Renal Fanconi syndrome (HP:0001994)3.63753129
31Choroideremia (HP:0001139)3.57125654
32Bony spicule pigmentary retinopathy (HP:0007737)3.56379697
33Increased hepatocellular lipid droplets (HP:0006565)3.53118042
34Squamous cell carcinoma (HP:0002860)3.51688948
35Lipid accumulation in hepatocytes (HP:0006561)3.46469620
36Anteriorly placed anus (HP:0001545)3.41509998
37Patellar aplasia (HP:0006443)3.23974513
38Abnormality of the costochondral junction (HP:0000919)3.15068365
39Hypoalbuminemia (HP:0003073)3.12667974
40Abnormal albumin level (HP:0012116)3.12667974
41Decreased central vision (HP:0007663)3.11572175
42Decreased electroretinogram (ERG) amplitude (HP:0000654)3.10215922
43Atrioventricular block (HP:0001678)3.09798407
44Chorioretinal atrophy (HP:0000533)3.09383040
45Myotonia (HP:0002486)3.04173338
46Short chin (HP:0000331)3.03358358
47Aplasia/Hypoplasia of the patella (HP:0006498)2.99024794
48Abnormality of placental membranes (HP:0011409)2.94980492
49Amniotic constriction ring (HP:0009775)2.94980492
50Enlarged epiphyses (HP:0010580)2.87501104
51Hypophosphatemic rickets (HP:0004912)2.81340060
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78187100
53Capillary hemangiomas (HP:0005306)2.74385028
54Joint stiffness (HP:0001387)2.73072098
55Increased muscle lipid content (HP:0009058)2.68095305
56Increased intramyocellular lipid droplets (HP:0012240)2.66031350
57Widely patent fontanelles and sutures (HP:0004492)2.63240748
58Zonular cataract (HP:0010920)2.61324756
59Absent thumb (HP:0009777)2.59492649
60Neonatal respiratory distress (HP:0002643)2.56611960
61Bowing of the arm (HP:0006488)2.53718806
62Bowed forearm bones (HP:0003956)2.53718806
63Neonatal onset (HP:0003623)2.48393794
64Abnormal epiphyseal ossification (HP:0010656)2.46916774
65Choanal stenosis (HP:0000452)2.45410889
66Narrow nasal bridge (HP:0000446)2.44347607
67Premature graying of hair (HP:0002216)2.37814032
68Basal cell carcinoma (HP:0002671)2.34101176
69Male infertility (HP:0003251)2.31025097
70Flat occiput (HP:0005469)2.29279351
71Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27595919
72Thin ribs (HP:0000883)2.25443341
73Respiratory difficulties (HP:0002880)2.25236726
74Diminished movement (HP:0002374)2.20249849
75Abnormal urine phosphate concentration (HP:0012599)2.19749418
76Exertional dyspnea (HP:0002875)2.18070660
77Increased number of teeth (HP:0011069)2.15925982
78Short humerus (HP:0005792)2.15101145
79Myopathic facies (HP:0002058)2.13687073
80Epiphyseal stippling (HP:0010655)2.13334902
81Pterygium (HP:0001059)2.08911128
82Abnormality of renal resorption (HP:0011038)2.06724498
83Abnormality of the common coagulation pathway (HP:0010990)2.06279272
84Heart block (HP:0012722)1.98995590
85Polydipsia (HP:0001959)1.98684332
86Abnormal drinking behavior (HP:0030082)1.98684332
87Birth length less than 3rd percentile (HP:0003561)1.96052299
88Cheilitis (HP:0100825)1.93302348
89Aplasia/hypoplasia of the humerus (HP:0006507)1.92913415
90Malignant hyperthermia (HP:0002047)1.92590367
91Cystic hygroma (HP:0000476)1.91261511
92Abnormal atrioventricular conduction (HP:0005150)1.87476134
93Absent radius (HP:0003974)1.86192052
94Abnormality of polysaccharide metabolism (HP:0011012)1.82598021
95Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82598021
96Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82598021
97Long clavicles (HP:0000890)1.77374519
98Aplasia involving forearm bones (HP:0009822)1.75594180
99Absent forearm bone (HP:0003953)1.75594180
100Pendular nystagmus (HP:0012043)1.74544360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.36652702
2MUSK3.88869192
3BLK3.05422185
4SIK22.53432133
5TLK12.42081082
6TRIB32.35874224
7TESK22.31357893
8GRK62.15435193
9SIK12.06214651
10ERN12.02905739
11MAPK1510.4256721
12IRAK21.67557045
13DYRK1B1.64209077
14STK161.43765482
15PRKD21.42465275
16MAP2K31.35015355
17PDPK11.19467183
18WNK11.17870173
19ADRBK11.13882731
20PRKD31.13497908
21CDK41.11530708
22CCNB11.09082866
23CDK151.06577687
24CDK11A1.02408409
25TBK11.01837473
26CDK180.98820426
27CSK0.96948294
28MARK20.95643432
29ZAK0.95552599
30RPS6KA20.95468646
31ZAP700.93917695
32ARAF0.93004826
33EEF2K0.91545065
34ACVR1B0.88319065
35PRKD10.85135479
36SIK30.83680829
37BMX0.82709474
38MAP2K60.79954306
39MAP4K10.79266496
40ICK0.78980674
41RPS6KA60.77447065
42BCKDK0.76954405
43MAPK120.76810782
44CDK140.75801785
45AURKA0.75409908
46MAPK110.74495556
47PIM20.72364164
48RPS6KL10.70805266
49RPS6KC10.70805266
50ADRBK20.69304883
51CDK60.66567279
52STK110.62979177
53PAK10.59471623
54SGK4940.57618750
55SGK2230.57618750
56PKN20.57340908
57TRIM280.53974250
58EPHA20.53128533
59MAP3K110.50156853
60SMG10.48075447
61NEK20.47735225
62MAP2K20.47137972
63TNK20.46738504
64RPS6KA50.46681278
65DAPK20.46504998
66MAPK80.45134181
67CAMKK10.44646648
68KSR20.43851575
69MTOR0.42091099
70HIPK20.40940747
71IKBKE0.40703933
72CSNK1D0.40664070
73STK390.40002820
74MAP2K40.39776263
75DYRK30.38969432
76PRKCH0.37045278
77PRKAA10.36389914
78CDK50.36166926
79IKBKB0.34220685
80MAP3K70.33590614
81TAOK30.33158763
82RAF10.32377094
83MELK0.32083079
84MAPK130.32021916
85ATR0.30321504
86BMPR1B0.29311556
87PDK20.28509864
88AKT20.26921198
89DYRK20.26011305
90CHEK20.25843019
91RPS6KA10.24122806
92TYRO30.24116298
93LYN0.23534246
94PAK60.21896349
95PRPF4B0.21891780
96OXSR10.21038778
97PRKCQ0.18718774
98PTK60.17841967
99PLK10.17776837
100MST1R0.16706130

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.69111537
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001306.80246770
3Sulfur relay system_Homo sapiens_hsa041225.36590158
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.80358519
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.13968618
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.85590647
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.72376707
8Fructose and mannose metabolism_Homo sapiens_hsa000512.68141176
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.55959086
10Sphingolipid metabolism_Homo sapiens_hsa006002.19935982
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91075216
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67897862
13Circadian rhythm_Homo sapiens_hsa047101.66547036
14Hedgehog signaling pathway_Homo sapiens_hsa043401.44046028
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43214756
16Taste transduction_Homo sapiens_hsa047421.42857826
17Fanconi anemia pathway_Homo sapiens_hsa034601.32397468
18Other glycan degradation_Homo sapiens_hsa005111.32067123
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24887440
20Nicotine addiction_Homo sapiens_hsa050331.21930307
21mTOR signaling pathway_Homo sapiens_hsa041500.95598168
22Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92638173
23Vitamin digestion and absorption_Homo sapiens_hsa049770.92262789
24Cocaine addiction_Homo sapiens_hsa050300.88326234
25Lysosome_Homo sapiens_hsa041420.84181859
26Inositol phosphate metabolism_Homo sapiens_hsa005620.80757464
27Ovarian steroidogenesis_Homo sapiens_hsa049130.74982914
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73987044
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69707068
30Melanogenesis_Homo sapiens_hsa049160.68600547
31Base excision repair_Homo sapiens_hsa034100.67882699
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66942475
33VEGF signaling pathway_Homo sapiens_hsa043700.66612016
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64778841
35Lysine degradation_Homo sapiens_hsa003100.62360564
36Basal cell carcinoma_Homo sapiens_hsa052170.61022483
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60534643
38Calcium signaling pathway_Homo sapiens_hsa040200.60414973
39Endocytosis_Homo sapiens_hsa041440.59834939
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59002744
41Notch signaling pathway_Homo sapiens_hsa043300.58303704
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.54149464
43Hippo signaling pathway_Homo sapiens_hsa043900.52528291
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.51048097
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49783215
46Bladder cancer_Homo sapiens_hsa052190.47941770
47Alcoholism_Homo sapiens_hsa050340.45511211
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45103513
49Chemical carcinogenesis_Homo sapiens_hsa052040.43390022
50Insulin resistance_Homo sapiens_hsa049310.42024597
51Phenylalanine metabolism_Homo sapiens_hsa003600.41569409
52Axon guidance_Homo sapiens_hsa043600.41520995
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39394994
54N-Glycan biosynthesis_Homo sapiens_hsa005100.37092097
55RNA polymerase_Homo sapiens_hsa030200.37009518
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36971945
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33371377
58Gap junction_Homo sapiens_hsa045400.32942164
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32423925
60ABC transporters_Homo sapiens_hsa020100.31755927
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30173971
62Hepatitis C_Homo sapiens_hsa051600.29206810
63Phototransduction_Homo sapiens_hsa047440.28782496
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26021722
65Metabolic pathways_Homo sapiens_hsa011000.25511862
66Cholinergic synapse_Homo sapiens_hsa047250.25164924
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24425701
68Morphine addiction_Homo sapiens_hsa050320.23782936
69Pyrimidine metabolism_Homo sapiens_hsa002400.22945369
70Acute myeloid leukemia_Homo sapiens_hsa052210.22694612
71Pyruvate metabolism_Homo sapiens_hsa006200.22117770
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.21404685
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19670515
74MAPK signaling pathway_Homo sapiens_hsa040100.19457376
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18738711
76Endometrial cancer_Homo sapiens_hsa052130.17086603
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17077903
78cAMP signaling pathway_Homo sapiens_hsa040240.16549724
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.16341427
80Amphetamine addiction_Homo sapiens_hsa050310.15499970
81Bile secretion_Homo sapiens_hsa049760.15203345
82AMPK signaling pathway_Homo sapiens_hsa041520.15021570
83Non-small cell lung cancer_Homo sapiens_hsa052230.14746637
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14369476
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.13806626
86Apoptosis_Homo sapiens_hsa042100.13731313
87Glutamatergic synapse_Homo sapiens_hsa047240.12254738
88Fatty acid degradation_Homo sapiens_hsa000710.11433193
89PPAR signaling pathway_Homo sapiens_hsa033200.11355313
90Biosynthesis of amino acids_Homo sapiens_hsa012300.11342357
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10154687
92Dorso-ventral axis formation_Homo sapiens_hsa043200.09715802
93Arginine biosynthesis_Homo sapiens_hsa002200.09625522
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08926533
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.08747221
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.07850166
97Basal transcription factors_Homo sapiens_hsa030220.07819614
98Histidine metabolism_Homo sapiens_hsa003400.06982957
99Tyrosine metabolism_Homo sapiens_hsa003500.05472637
100Insulin signaling pathway_Homo sapiens_hsa049100.04727544

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