ZNF45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.46471707
2nuclear pore organization (GO:0006999)5.79086200
3mitotic sister chromatid cohesion (GO:0007064)5.24259931
4pore complex assembly (GO:0046931)5.08614412
5somatic hypermutation of immunoglobulin genes (GO:0016446)4.60961104
6somatic diversification of immune receptors via somatic mutation (GO:0002566)4.60961104
7mitotic sister chromatid segregation (GO:0000070)4.44167837
8sister chromatid segregation (GO:0000819)4.42674637
9mitotic metaphase plate congression (GO:0007080)4.14280974
10DNA replication checkpoint (GO:0000076)4.08704833
11regulation of DNA endoreduplication (GO:0032875)4.05765304
12mitotic chromosome condensation (GO:0007076)4.04020578
13histone H2A acetylation (GO:0043968)4.02215603
14protein localization to kinetochore (GO:0034501)3.94811974
15ribosome assembly (GO:0042255)3.94625577
16negative regulation of chromosome segregation (GO:0051985)3.92412420
17DNA double-strand break processing (GO:0000729)3.90656746
18protein localization to chromosome, centromeric region (GO:0071459)3.88775132
19spindle checkpoint (GO:0031577)3.81390253
20negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.80464392
21negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.80464392
22negative regulation of mitotic sister chromatid segregation (GO:0033048)3.80464392
23negative regulation of mitotic sister chromatid separation (GO:2000816)3.80464392
24negative regulation of sister chromatid segregation (GO:0033046)3.80464392
25mitotic spindle checkpoint (GO:0071174)3.79735158
26DNA strand elongation involved in DNA replication (GO:0006271)3.77978970
27regulation of mitotic metaphase/anaphase transition (GO:0030071)3.76262886
28regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.76262886
29mitotic nuclear envelope disassembly (GO:0007077)3.75282698
30regulation of mitotic sister chromatid separation (GO:0010965)3.71706928
31regulation of mitotic sister chromatid segregation (GO:0033047)3.71706928
32regulation of sister chromatid segregation (GO:0033045)3.71706928
33metaphase plate congression (GO:0051310)3.70722100
34mitotic spindle assembly checkpoint (GO:0007094)3.69461793
35DNA unwinding involved in DNA replication (GO:0006268)3.67264260
36DNA strand elongation (GO:0022616)3.65462825
37non-recombinational repair (GO:0000726)3.63951095
38double-strand break repair via nonhomologous end joining (GO:0006303)3.63951095
39positive regulation of chromosome segregation (GO:0051984)3.63444998
40spindle assembly checkpoint (GO:0071173)3.62434084
41regulation of sister chromatid cohesion (GO:0007063)3.62246034
42regulation of chromosome segregation (GO:0051983)3.60007626
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58361004
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58361004
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.58361004
46DNA topological change (GO:0006265)3.57869977
47nuclear envelope disassembly (GO:0051081)3.54811638
48membrane disassembly (GO:0030397)3.54811638
49establishment of chromosome localization (GO:0051303)3.54217278
50regulation of centriole replication (GO:0046599)3.52884341
51attachment of spindle microtubules to kinetochore (GO:0008608)3.51698126
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.45734528
53sister chromatid cohesion (GO:0007062)3.43970848
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40893352
55regulation of helicase activity (GO:0051095)3.40195351
56establishment of integrated proviral latency (GO:0075713)3.33706766
57synapsis (GO:0007129)3.33638042
58replication fork processing (GO:0031297)3.31672632
59DNA geometric change (GO:0032392)3.31659008
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31353284
61DNA duplex unwinding (GO:0032508)3.30209249
62telomere maintenance via semi-conservative replication (GO:0032201)3.26920141
63DNA replication-dependent nucleosome organization (GO:0034723)3.25719199
64DNA replication-dependent nucleosome assembly (GO:0006335)3.25719199
65DNA replication initiation (GO:0006270)3.24485065
66DNA strand renaturation (GO:0000733)3.23271257
67spliceosomal tri-snRNP complex assembly (GO:0000244)3.20973211
68DNA ligation (GO:0006266)3.18230082
69kinetochore organization (GO:0051383)3.15174675
70chromatin remodeling at centromere (GO:0031055)3.11851039
71meiotic chromosome segregation (GO:0045132)3.11451271
72CENP-A containing nucleosome assembly (GO:0034080)3.09139055
73mitotic recombination (GO:0006312)3.05983867
74telomere maintenance via recombination (GO:0000722)3.05765064
75protein localization to chromosome (GO:0034502)3.05440267
76somatic cell DNA recombination (GO:0016444)2.99861032
77somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.99861032
78somatic diversification of immune receptors (GO:0002200)2.98008600
79regulation of histone H3-K9 methylation (GO:0051570)2.97680154
80regulation of centrosome cycle (GO:0046605)2.96650922
81regulation of centrosome duplication (GO:0010824)2.94367869
82nuclear envelope organization (GO:0006998)2.94119550
83negative regulation of mitosis (GO:0045839)2.92605439
84nucleotide-excision repair, DNA gap filling (GO:0006297)2.92368579
85negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.90972121
86DNA synthesis involved in DNA repair (GO:0000731)2.90650464
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89644077
88somatic recombination of immunoglobulin gene segments (GO:0016447)2.89571999
89somatic diversification of immunoglobulins (GO:0016445)2.88194289
90postreplication repair (GO:0006301)2.87735706
91DNA conformation change (GO:0071103)2.87060510
92V(D)J recombination (GO:0033151)2.86584791
93chromosome segregation (GO:0007059)2.85302548
94negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83855369
95negative regulation of DNA recombination (GO:0045910)2.82873785
96negative regulation of mRNA processing (GO:0050686)2.81688084
97DNA replication-independent nucleosome assembly (GO:0006336)2.81652705
98DNA replication-independent nucleosome organization (GO:0034724)2.81652705
99negative regulation of cell cycle G2/M phase transition (GO:1902750)2.81486884
100regulation of RNA export from nucleus (GO:0046831)2.78397362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25928746
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.75149028
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.26572798
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16047305
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07330156
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80772387
7* NOTCH1_21737748_ChIP-Seq_TLL_Human2.80585477
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.78816596
9* ELK1_19687146_ChIP-ChIP_HELA_Human2.54270449
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53073438
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.51656118
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.51127276
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.50987041
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47468495
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46658939
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.35372876
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.32329071
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17201216
19VDR_23849224_ChIP-Seq_CD4+_Human2.07398398
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97251751
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97005617
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95494394
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95479878
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.92284554
25EWS_26573619_Chip-Seq_HEK293_Human1.92051147
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88871827
27FUS_26573619_Chip-Seq_HEK293_Human1.86931126
28AR_21909140_ChIP-Seq_LNCAP_Human1.81236616
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78443321
30FOXP3_21729870_ChIP-Seq_TREG_Human1.75772675
31* ETS1_20019798_ChIP-Seq_JURKAT_Human1.75035084
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73182848
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73106896
34DCP1A_22483619_ChIP-Seq_HELA_Human1.67244294
35CIITA_25753668_ChIP-Seq_RAJI_Human1.67161004
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65884912
37ZNF274_21170338_ChIP-Seq_K562_Hela1.65033829
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62440051
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61100405
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57804053
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56431690
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52671286
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51277197
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48561896
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44553644
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41359151
47TTF2_22483619_ChIP-Seq_HELA_Human1.38622082
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36882327
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35385788
50IGF1R_20145208_ChIP-Seq_DFB_Human1.33949220
51E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33774438
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33536936
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33524767
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.32628283
55KDM5A_27292631_Chip-Seq_BREAST_Human1.29249965
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29156695
57* GABP_19822575_ChIP-Seq_HepG2_Human1.29136849
58MYC_18940864_ChIP-ChIP_HL60_Human1.25328865
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25097169
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24848066
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21191108
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16774980
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15598750
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.12400828
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.11036456
66IRF1_19129219_ChIP-ChIP_H3396_Human1.10326162
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.10322089
68FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09708666
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07916058
70XRN2_22483619_ChIP-Seq_HELA_Human1.06023021
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03102434
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99978321
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98359166
74ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98002069
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97295777
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97231128
77SOX2_16153702_ChIP-ChIP_HESCs_Human0.97215493
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93240510
79PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92287035
80P300_19829295_ChIP-Seq_ESCs_Human0.92253739
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92204429
82PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91860484
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91636615
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90933473
85NANOG_16153702_ChIP-ChIP_HESCs_Human0.89374688
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85916766
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85054837
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.84748815
89VDR_22108803_ChIP-Seq_LS180_Human0.82579310
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81554433
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81235050
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79062704
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79021916
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78474260
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77035914
96SRF_21415370_ChIP-Seq_HL-1_Mouse0.76764926
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.74451568
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73805143
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.73542570
100STAT3_23295773_ChIP-Seq_U87_Human0.72574815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.51777985
2MP0010094_abnormal_chromosome_stability5.03872779
3MP0003111_abnormal_nucleus_morphology3.75347328
4MP0008058_abnormal_DNA_repair3.64232214
5MP0003693_abnormal_embryo_hatching3.60131819
6MP0003077_abnormal_cell_cycle3.52008120
7MP0004957_abnormal_blastocyst_morpholog3.31710631
8MP0010307_abnormal_tumor_latency2.77012306
9MP0009697_abnormal_copulation2.73703577
10MP0008007_abnormal_cellular_replicative2.52215871
11MP0008932_abnormal_embryonic_tissue2.52080108
12MP0002009_preneoplasia2.43105725
13MP0008877_abnormal_DNA_methylation2.13352702
14MP0002102_abnormal_ear_morphology1.80604842
15MP0000372_irregular_coat_pigmentation1.71812613
16MP0000350_abnormal_cell_proliferation1.70955542
17MP0003786_premature_aging1.68252890
18MP0010352_gastrointestinal_tract_polyps1.60901638
19MP0005380_embryogenesis_phenotype1.60621535
20MP0001672_abnormal_embryogenesis/_devel1.60621535
21MP0001730_embryonic_growth_arrest1.60228780
22MP0004808_abnormal_hematopoietic_stem1.58057656
23MP0003984_embryonic_growth_retardation1.53049329
24MP0001697_abnormal_embryo_size1.52394640
25MP0000516_abnormal_urinary_system1.51644150
26MP0005367_renal/urinary_system_phenotyp1.51644150
27MP0003937_abnormal_limbs/digits/tail_de1.51320793
28MP0002084_abnormal_developmental_patter1.51137236
29MP0005171_absent_coat_pigmentation1.50915758
30MP0002396_abnormal_hematopoietic_system1.49963302
31MP0002088_abnormal_embryonic_growth/wei1.49459925
32MP0003567_abnormal_fetal_cardiomyocyte1.46395639
33MP0000537_abnormal_urethra_morphology1.45417410
34MP0002085_abnormal_embryonic_tissue1.37468108
35MP0000313_abnormal_cell_death1.31850182
36MP0003943_abnormal_hepatobiliary_system1.24578508
37MP0003718_maternal_effect1.22923907
38MP0009672_abnormal_birth_weight1.20357820
39MP0003221_abnormal_cardiomyocyte_apopto1.19056808
40MP0002086_abnormal_extraembryonic_tissu1.17512863
41MP0002080_prenatal_lethality1.16876344
42MP0004197_abnormal_fetal_growth/weight/1.12617994
43MP0009703_decreased_birth_body1.10412311
44MP0008260_abnormal_autophagy1.10006660
45MP0001929_abnormal_gametogenesis1.07901680
46MP0008961_abnormal_basal_metabolism1.07291245
47MP0009053_abnormal_anal_canal1.06094212
48MP0000490_abnormal_crypts_of1.04019462
49MP0001293_anophthalmia1.04014682
50MP0000383_abnormal_hair_follicle1.03630478
51MP0002210_abnormal_sex_determination0.99896488
52MP0000647_abnormal_sebaceous_gland0.99383575
53MP0001286_abnormal_eye_development0.99114364
54MP0006292_abnormal_olfactory_placode0.99097358
55MP0003755_abnormal_palate_morphology0.98882696
56MP0000427_abnormal_hair_cycle0.98119147
57MP0003935_abnormal_craniofacial_develop0.97016040
58MP0000613_abnormal_salivary_gland0.95961195
59MP0000428_abnormal_craniofacial_morphol0.95001651
60MP0000049_abnormal_middle_ear0.94197099
61MP0006035_abnormal_mitochondrial_morpho0.92218166
62MP0002019_abnormal_tumor_incidence0.91598875
63MP0001145_abnormal_male_reproductive0.89619605
64MP0002697_abnormal_eye_size0.88017009
65MP0005187_abnormal_penis_morphology0.87087676
66MP0000358_abnormal_cell_content/0.87071682
67MP0001299_abnormal_eye_distance/0.86355896
68MP0001529_abnormal_vocalization0.84976061
69MP0002006_tumorigenesis0.84771246
70MP0003656_abnormal_erythrocyte_physiolo0.84746734
71MP0002233_abnormal_nose_morphology0.81949245
72MP0005623_abnormal_meninges_morphology0.81774659
73MP0000653_abnormal_sex_gland0.81543089
74MP0002166_altered_tumor_susceptibility0.79441974
75MP0010368_abnormal_lymphatic_system0.79418892
76MP0003646_muscle_fatigue0.78303385
77MP0001661_extended_life_span0.78194385
78MP0001346_abnormal_lacrimal_gland0.76796710
79MP0000703_abnormal_thymus_morphology0.75218522
80MP0003950_abnormal_plasma_membrane0.74759747
81MP0002282_abnormal_trachea_morphology0.74523406
82MP0003890_abnormal_embryonic-extraembry0.73859164
83MP0001119_abnormal_female_reproductive0.73059524
84MP0003861_abnormal_nervous_system0.72344211
85MP0000432_abnormal_head_morphology0.72007262
86MP0009278_abnormal_bone_marrow0.71973941
87MP0010678_abnormal_skin_adnexa0.69191014
88MP0002160_abnormal_reproductive_system0.68849026
89MP0002877_abnormal_melanocyte_morpholog0.67628396
90MP0003315_abnormal_perineum_morphology0.67556508
91MP0003385_abnormal_body_wall0.66960026
92MP0005384_cellular_phenotype0.66244096
93MP0001873_stomach_inflammation0.64842127
94MP0001849_ear_inflammation0.64182074
95MP0001984_abnormal_olfaction0.63538059
96MP0003941_abnormal_skin_development0.62604351
97MP0010030_abnormal_orbit_morphology0.62436579
98MP0002108_abnormal_muscle_morphology0.62359470
99MP0003698_abnormal_male_reproductive0.61582417
100MP0005621_abnormal_cell_physiology0.60932255

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.38470162
2Volvulus (HP:0002580)4.30913611
3Chromsome breakage (HP:0040012)3.98383736
4Abnormality of chromosome stability (HP:0003220)3.61051148
5Medulloblastoma (HP:0002885)3.25156956
6Bifid tongue (HP:0010297)3.18610828
7Short 4th metacarpal (HP:0010044)3.18409593
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.18409593
9Cortical dysplasia (HP:0002539)3.16034986
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.10165013
11Stenosis of the external auditory canal (HP:0000402)3.00456932
12Abnormality of the 4th metacarpal (HP:0010012)2.90291228
13Colon cancer (HP:0003003)2.89916795
14Abnormality of the preputium (HP:0100587)2.85677876
15Meckel diverticulum (HP:0002245)2.83381508
16Abnormality of the carotid arteries (HP:0005344)2.78608259
17Nephroblastoma (Wilms tumor) (HP:0002667)2.78008552
18Abnormality of the ileum (HP:0001549)2.76127366
19Abnormal lung lobation (HP:0002101)2.73345006
20Sloping forehead (HP:0000340)2.71537724
21Embryonal renal neoplasm (HP:0011794)2.63469725
22Ectopic kidney (HP:0000086)2.57878480
23Duodenal stenosis (HP:0100867)2.52101278
24Small intestinal stenosis (HP:0012848)2.52101278
25Glioma (HP:0009733)2.47922230
26Ependymoma (HP:0002888)2.46185143
27Long clavicles (HP:0000890)2.40477635
28Abnormality of the duodenum (HP:0002246)2.26492137
29Spinal muscular atrophy (HP:0007269)2.25863224
30Increased nuchal translucency (HP:0010880)2.24331945
31Astrocytoma (HP:0009592)2.21069051
32Abnormality of the astrocytes (HP:0100707)2.21069051
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16891891
34Deep philtrum (HP:0002002)2.16089127
35Capillary hemangiomas (HP:0005306)2.15706302
36Birth length less than 3rd percentile (HP:0003561)2.15550670
37Rhabdomyosarcoma (HP:0002859)2.12673939
38Clubbing of toes (HP:0100760)2.10022707
39Abnormality of DNA repair (HP:0003254)2.05467721
40Urethral obstruction (HP:0000796)2.04788349
41Gonadotropin excess (HP:0000837)2.02021604
42Basal cell carcinoma (HP:0002671)2.00814598
43Neoplasm of the oral cavity (HP:0100649)1.99331261
44Myelodysplasia (HP:0002863)1.96060325
45Overlapping toe (HP:0001845)1.93991265
46Preaxial hand polydactyly (HP:0001177)1.93195751
47Tubulointerstitial nephritis (HP:0001970)1.89896248
48Agnosia (HP:0010524)1.88988423
49Abnormal number of incisors (HP:0011064)1.88804713
50Acute lymphatic leukemia (HP:0006721)1.88692663
51Astigmatism (HP:0000483)1.86400546
52Cafe-au-lait spot (HP:0000957)1.86132284
53Abnormality of the labia minora (HP:0012880)1.80753714
54Impaired proprioception (HP:0010831)1.80432837
55Intestinal atresia (HP:0011100)1.80015422
56Arterial tortuosity (HP:0005116)1.78616639
57High anterior hairline (HP:0009890)1.77374719
58Bladder carcinoma (HP:0002862)1.76687513
59Bladder neoplasm (HP:0009725)1.76687513
60Absent radius (HP:0003974)1.76529147
61Abnormal foot bone ossification (HP:0010675)1.75555964
62Limb hypertonia (HP:0002509)1.75414909
63Neoplasm of striated muscle (HP:0009728)1.75217696
64Spastic diplegia (HP:0001264)1.74988948
65Arteriovenous malformation (HP:0100026)1.74931352
66Neoplasm of the adrenal cortex (HP:0100641)1.74068583
67Facial hemangioma (HP:0000329)1.72977341
68Abnormality of midbrain morphology (HP:0002418)1.72962056
69Molar tooth sign on MRI (HP:0002419)1.72962056
70Duplication of thumb phalanx (HP:0009942)1.70226807
71Prominent nose (HP:0000448)1.68944258
72Triphalangeal thumb (HP:0001199)1.68903673
73Abnormality of chromosome segregation (HP:0002916)1.67119745
74Abnormality of the metopic suture (HP:0005556)1.65748339
75True hermaphroditism (HP:0010459)1.64661858
76Absent forearm bone (HP:0003953)1.60929912
77Aplasia involving forearm bones (HP:0009822)1.60929912
78Choanal atresia (HP:0000453)1.60570011
79Embryonal neoplasm (HP:0002898)1.60247670
80Hypoplastic pelvis (HP:0008839)1.59842849
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.59599127
82Hypoplastic labia majora (HP:0000059)1.57756605
83Gastrointestinal atresia (HP:0002589)1.57659899
84Increased number of teeth (HP:0011069)1.57380178
85Skull defect (HP:0001362)1.57226080
86Shoulder girdle muscle weakness (HP:0003547)1.57207850
87Abnormality of methionine metabolism (HP:0010901)1.56659722
88Abnormality of the incisor (HP:0000676)1.56301009
89Homocystinuria (HP:0002156)1.56203209
90Abnormality of homocysteine metabolism (HP:0010919)1.56203209
91Pendular nystagmus (HP:0012043)1.53637993
92Dyschromatopsia (HP:0007641)1.53439725
93Fibular hypoplasia (HP:0003038)1.53148927
94Short thumb (HP:0009778)1.52977538
95Limited elbow extension (HP:0001377)1.52940881
96Hyperventilation (HP:0002883)1.52606057
97Median cleft lip (HP:0000161)1.52566891
98Poikiloderma (HP:0001029)1.52441848
99Abnormality of the labia majora (HP:0012881)1.51968061
100Abnormality of the anterior horn cell (HP:0006802)1.51889043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.61142332
2BUB13.26444118
3CDC73.13054943
4SRPK12.79316395
5CDK82.66150382
6BRSK22.35959085
7BRD42.35718020
8TTK2.32794474
9MKNK22.30101896
10ZAK2.21747820
11NEK12.21694752
12WEE12.16170725
13TAF12.07556911
14PLK32.01704326
15MKNK11.98186171
16PLK41.93116691
17ERBB31.86844660
18CAMK1G1.86519172
19NUAK11.86305932
20CAMK1D1.83473116
21ATR1.77521514
22VRK11.71786256
23BCKDK1.71501621
24PNCK1.71113514
25CHEK21.63430560
26PLK11.62849154
27STK38L1.61233972
28TSSK61.55896035
29BMPR1B1.53644121
30BRSK11.53342438
31WNK31.48171705
32TXK1.38115534
33ACVR1B1.36859884
34TRIM281.35476558
35MAP4K21.35248294
36MAP3K41.34617378
37RPS6KA41.31313751
38CDK121.30258350
39CHEK11.28517797
40MELK1.26250386
41ATM1.21805689
42EIF2AK21.21724533
43DYRK31.18218199
44CDK71.14135760
45EIF2AK11.13310541
46CCNB11.12342727
47SCYL21.07014250
48CDK61.05483564
49AURKB1.04228812
50NEK91.02190420
51VRK20.99029571
52PIM20.97312099
53TGFBR10.92729793
54LATS10.90870009
55NEK20.90651152
56RAF10.87323859
57PASK0.85961985
58MAP3K100.85635931
59STK100.84587222
60PBK0.82334100
61FRK0.81955765
62AURKA0.79035741
63CDK40.78842732
64MAP2K70.77179245
65CDK90.75777752
66CASK0.72055184
67CSNK1G10.68433192
68MAP3K50.65002347
69PIM10.64688856
70YES10.64598460
71NLK0.63712980
72BCR0.63230818
73ERBB40.63023931
74CDK20.62869230
75CDK10.62632458
76STK30.62606354
77CDK30.61286039
78SMG10.61077573
79IRAK30.58604028
80RPS6KA50.55442403
81CSNK1A1L0.53184632
82CSNK1G30.49842565
83TEC0.48847895
84CSNK1G20.46751689
85CLK10.46148558
86PRKDC0.44871313
87TNIK0.39685516
88CDK190.38942026
89CSNK2A10.32054519
90STK40.31809359
91PLK20.31484929
92DMPK0.27507119
93CAMK40.26059775
94CSNK2A20.24862057
95MST40.22620593
96GSK3B0.22202781
97MAPK140.21976855
98EPHA30.21969711
99DYRK1B0.21083297
100CAMKK20.19669462

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.49120553
2DNA replication_Homo sapiens_hsa030304.02070346
3Mismatch repair_Homo sapiens_hsa034303.73951930
4Cell cycle_Homo sapiens_hsa041103.41054172
5Fanconi anemia pathway_Homo sapiens_hsa034603.33579425
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08273014
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.97731471
8Basal transcription factors_Homo sapiens_hsa030222.77396848
9RNA transport_Homo sapiens_hsa030132.76446057
10Homologous recombination_Homo sapiens_hsa034402.68435361
11Base excision repair_Homo sapiens_hsa034102.66651267
12Nucleotide excision repair_Homo sapiens_hsa034202.60378596
13Spliceosome_Homo sapiens_hsa030402.52453465
14RNA degradation_Homo sapiens_hsa030182.13088209
15Proteasome_Homo sapiens_hsa030502.09225798
16One carbon pool by folate_Homo sapiens_hsa006701.99405343
17mRNA surveillance pathway_Homo sapiens_hsa030151.84956756
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.72169382
19Selenocompound metabolism_Homo sapiens_hsa004501.70008030
20RNA polymerase_Homo sapiens_hsa030201.60897062
21p53 signaling pathway_Homo sapiens_hsa041151.52966087
22Pyrimidine metabolism_Homo sapiens_hsa002401.47332283
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38381935
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.33141120
25Oocyte meiosis_Homo sapiens_hsa041141.25330815
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22016417
27Propanoate metabolism_Homo sapiens_hsa006401.18635218
28TGF-beta signaling pathway_Homo sapiens_hsa043501.16510357
29Colorectal cancer_Homo sapiens_hsa052101.12767714
30MicroRNAs in cancer_Homo sapiens_hsa052061.12480129
31Viral carcinogenesis_Homo sapiens_hsa052031.07828993
32Regulation of autophagy_Homo sapiens_hsa041401.04985800
33Lysine degradation_Homo sapiens_hsa003101.04416299
34Systemic lupus erythematosus_Homo sapiens_hsa053221.04241506
35Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99514107
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92969316
37Dorso-ventral axis formation_Homo sapiens_hsa043200.91218770
38Purine metabolism_Homo sapiens_hsa002300.88838011
39Chronic myeloid leukemia_Homo sapiens_hsa052200.85731933
40Herpes simplex infection_Homo sapiens_hsa051680.85696830
41Epstein-Barr virus infection_Homo sapiens_hsa051690.84744249
42Pancreatic cancer_Homo sapiens_hsa052120.81217883
43Prostate cancer_Homo sapiens_hsa052150.81026598
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79832294
45Steroid biosynthesis_Homo sapiens_hsa001000.79827515
46Primary immunodeficiency_Homo sapiens_hsa053400.77687769
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77349199
48Hepatitis B_Homo sapiens_hsa051610.76456509
49Small cell lung cancer_Homo sapiens_hsa052220.75792538
50Basal cell carcinoma_Homo sapiens_hsa052170.75771080
51Alcoholism_Homo sapiens_hsa050340.74874646
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74192437
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74191792
54HTLV-I infection_Homo sapiens_hsa051660.73275344
55Hippo signaling pathway_Homo sapiens_hsa043900.69194909
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67609601
57Hedgehog signaling pathway_Homo sapiens_hsa043400.63285929
58FoxO signaling pathway_Homo sapiens_hsa040680.62335248
59Thyroid cancer_Homo sapiens_hsa052160.61269283
60Adherens junction_Homo sapiens_hsa045200.61018433
61Measles_Homo sapiens_hsa051620.60925928
62Circadian rhythm_Homo sapiens_hsa047100.59969435
63Biosynthesis of amino acids_Homo sapiens_hsa012300.53134319
64Wnt signaling pathway_Homo sapiens_hsa043100.52466935
65Melanoma_Homo sapiens_hsa052180.47061396
66Legionellosis_Homo sapiens_hsa051340.44871879
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.44475370
68Protein export_Homo sapiens_hsa030600.44216611
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43542301
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.43011571
71Apoptosis_Homo sapiens_hsa042100.42488074
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40201869
73Non-small cell lung cancer_Homo sapiens_hsa052230.38722370
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38564729
75N-Glycan biosynthesis_Homo sapiens_hsa005100.37931752
76Pathways in cancer_Homo sapiens_hsa052000.35476215
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34945901
78Sulfur relay system_Homo sapiens_hsa041220.34482083
79Influenza A_Homo sapiens_hsa051640.33862003
80Bladder cancer_Homo sapiens_hsa052190.32562599
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29968246
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29637412
83Carbon metabolism_Homo sapiens_hsa012000.29220459
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26548185
85Renal cell carcinoma_Homo sapiens_hsa052110.24754286
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24737116
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23816265
88T cell receptor signaling pathway_Homo sapiens_hsa046600.22328079
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22004824
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21849044
91Proteoglycans in cancer_Homo sapiens_hsa052050.17274650
92Fatty acid elongation_Homo sapiens_hsa000620.15845505
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15429261
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15276449
95Endometrial cancer_Homo sapiens_hsa052130.13907373
96Peroxisome_Homo sapiens_hsa041460.12774341
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12488739
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12038389
99Notch signaling pathway_Homo sapiens_hsa043300.11858224
100mTOR signaling pathway_Homo sapiens_hsa041500.09601090

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