ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.16397351
2	replication fork processing (GO:0031297)	4.15296943
3	neural tube formation (GO:0001841)	4.01685466
4	prenylation (GO:0097354)	3.91028547
5	protein prenylation (GO:0018342)	3.91028547
6	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.88178496
7	protein K11-linked deubiquitination (GO:0035871)	3.82419249
8	regulation of centriole replication (GO:0046599)	3.57790110
9	mitotic sister chromatid cohesion (GO:0007064)	3.52878056
10	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.45407073
11	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.41286681
12	regulation of translation, ncRNA-mediated (GO:0045974)	3.41286681
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.41286681
14	regulation of DNA endoreduplication (GO:0032875)	3.34025531
15	resolution of meiotic recombination intermediates (GO:0000712)	3.33057771
16	nuclear pore complex assembly (GO:0051292)	3.27202548
17	monoubiquitinated protein deubiquitination (GO:0035520)	3.26945481
18	response to pheromone (GO:0019236)	3.24202038
19	microtubule anchoring (GO:0034453)	3.22403552
20	pyrimidine nucleobase catabolic process (GO:0006208)	3.22134979
21	synapsis (GO:0007129)	3.15319338
22	nuclear pore organization (GO:0006999)	3.13346964
23	regulation of centrosome duplication (GO:0010824)	3.11812271
24	centriole replication (GO:0007099)	3.08297689
25	establishment of protein localization to Golgi (GO:0072600)	3.07344976
26	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.04426335
27	regulation of mitotic spindle checkpoint (GO:1903504)	3.04426335
28	presynaptic membrane organization (GO:0097090)	3.01673887
29	presynaptic membrane assembly (GO:0097105)	2.96205178
30	recombinational repair (GO:0000725)	2.95530671
31	double-strand break repair via homologous recombination (GO:0000724)	2.95204045
32	attachment of spindle microtubules to kinetochore (GO:0008608)	2.92251391
33	regulation of glucokinase activity (GO:0033131)	2.91730436
34	regulation of hexokinase activity (GO:1903299)	2.91730436
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.88089412
36	histone mRNA catabolic process (GO:0071044)	2.87351730
37	reciprocal DNA recombination (GO:0035825)	2.85607298
38	reciprocal meiotic recombination (GO:0007131)	2.85607298
39	negative regulation of DNA recombination (GO:0045910)	2.82941451
40	histone H2A acetylation (GO:0043968)	2.82775169
41	positive regulation of developmental pigmentation (GO:0048087)	2.80700040
42	atrial cardiac muscle cell action potential (GO:0086014)	2.76997343
43	intraciliary transport (GO:0042073)	2.76701583
44	nucleobase catabolic process (GO:0046113)	2.75410348
45	protein targeting to Golgi (GO:0000042)	2.75127073
46	postreplication repair (GO:0006301)	2.73992113
47	sister chromatid cohesion (GO:0007062)	2.68960623
48	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.68136241
49	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.68136241
50	meiotic chromosome segregation (GO:0045132)	2.68067301
51	regulation of telomere maintenance (GO:0032204)	2.67973104
52	regulation of centrosome cycle (GO:0046605)	2.67955836
53	pore complex assembly (GO:0046931)	2.67631853
54	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.66514154
55	positive regulation of mRNA processing (GO:0050685)	2.64202033
56	rRNA catabolic process (GO:0016075)	2.63316419
57	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.63167978
58	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.62447535
59	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.62169388
60	kinetochore organization (GO:0051383)	2.60800684
61	L-fucose catabolic process (GO:0042355)	2.60740359
62	fucose catabolic process (GO:0019317)	2.60740359
63	L-fucose metabolic process (GO:0042354)	2.60740359
64	photoreceptor cell maintenance (GO:0045494)	2.60369713
65	pyrimidine dimer repair (GO:0006290)	2.56422505
66	peptidyl-lysine trimethylation (GO:0018023)	2.55535231
67	intra-S DNA damage checkpoint (GO:0031573)	2.54369400
68	single strand break repair (GO:0000012)	2.54094572
69	non-recombinational repair (GO:0000726)	2.53855505
70	double-strand break repair via nonhomologous end joining (GO:0006303)	2.53855505
71	behavioral response to nicotine (GO:0035095)	2.52817649
72	regulation of pigment cell differentiation (GO:0050932)	2.52504351
73	microtubule organizing center organization (GO:0031023)	2.51809001
74	cytoplasmic mRNA processing body assembly (GO:0033962)	2.51444785
75	microtubule depolymerization (GO:0007019)	2.49688361
76	keratinocyte development (GO:0003334)	2.48688532
77	negative regulation of neurotransmitter transport (GO:0051589)	2.48550125
78	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.47665757
79	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.47665757
80	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.47665757
81	cilium morphogenesis (GO:0060271)	2.47585616
82	signal peptide processing (GO:0006465)	2.47563187
83	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.46987453
84	positive regulation of mRNA metabolic process (GO:1903313)	2.46114616
85	inositol phosphate catabolic process (GO:0071545)	2.45151283
86	centrosome organization (GO:0051297)	2.43648432
87	regulation of sarcomere organization (GO:0060297)	2.43370255
88	histone H3-K9 methylation (GO:0051567)	2.41053270
89	pancreas development (GO:0031016)	2.39681566
90	DNA replication checkpoint (GO:0000076)	2.39627175
91	piRNA metabolic process (GO:0034587)	2.39268573
92	olfactory bulb development (GO:0021772)	2.39063823
93	histone H3-K4 trimethylation (GO:0080182)	2.38939660
94	cilium organization (GO:0044782)	2.38825308
95	chromatin remodeling at centromere (GO:0031055)	2.37252783
96	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.36292861
97	regulation of Rac protein signal transduction (GO:0035020)	2.35366152
98	histone exchange (GO:0043486)	2.35010511
99	cilium assembly (GO:0042384)	2.34972730
100	protein K6-linked ubiquitination (GO:0085020)	2.34399892

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.72926423
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.24760564
3	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.14297005
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.88133096
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.86883854
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86132886
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.75316263
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71535294
9	FUS_26573619_Chip-Seq_HEK293_Human	2.58556544
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.55838017
11	* EWS_26573619_Chip-Seq_HEK293_Human	2.50037803
12	VDR_22108803_ChIP-Seq_LS180_Human	2.31966010
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.31903275
14	P300_19829295_ChIP-Seq_ESCs_Human	2.17439244
15	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.15518116
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09444321
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.08449698
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.05317698
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.03110939
20	E2F7_22180533_ChIP-Seq_HELA_Human	1.99949832
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.93537965
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89317316
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82577785
24	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.75649876
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.73782209
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.72205424
27	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.70684399
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69920615
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.67790264
30	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.67690462
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64749405
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64363600
33	STAT3_23295773_ChIP-Seq_U87_Human	1.63511733
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61004489
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60521627
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58808384
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55924976
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.55481739
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.54416332
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54416332
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49427834
42	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.48608039
43	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.47871587
44	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.45592924
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44475460
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43806373
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.40805341
48	TCF4_23295773_ChIP-Seq_U87_Human	1.38864859
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37728530
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34595590
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34396415
52	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.33583696
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33161497
54	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.32168897
55	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.30773149
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30427987
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.29972952
58	AR_25329375_ChIP-Seq_VCAP_Human	1.29619933
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28653900
60	P53_22387025_ChIP-Seq_ESCs_Mouse	1.28211996
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27556809
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27439243
63	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.27196736
64	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.26996910
65	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.26815833
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.26672800
67	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.26096155
68	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.24528965
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24485120
70	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.23218664
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21015395
72	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20960655
73	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20960655
74	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.19816631
75	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.18968860
76	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18619016
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15493167
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14217780
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13879400
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.13870269
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13355722
82	* VDR_23849224_ChIP-Seq_CD4+_Human	1.11477208
83	P300_18555785_Chip-Seq_ESCs_Mouse	1.10402039
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10022151
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.09917822
86	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.06243522
87	AR_21572438_ChIP-Seq_LNCaP_Human	1.05307248
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05030310
89	TP53_22573176_ChIP-Seq_HFKS_Human	1.04666037
90	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04339593
91	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.04247301
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03462192
93	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.03405093
94	CDX2_22108803_ChIP-Seq_LS180_Human	1.02679671
95	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01500638
96	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01500638
97	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.01144714
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00300629
99	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.99639257
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97737726

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.10652496
2	MP0000569_abnormal_digit_pigmentation	4.05387511
3	MP0008877_abnormal_DNA_methylation	3.83989959
4	MP0003787_abnormal_imprinting	2.94372329
5	MP0008058_abnormal_DNA_repair	2.36007581
6	MP0004147_increased_porphyrin_level	2.30092147
7	MP0003890_abnormal_embryonic-extraembry	2.15167531
8	MP0010094_abnormal_chromosome_stability	2.02513922
9	MP0003121_genomic_imprinting	1.99521108
10	MP0002102_abnormal_ear_morphology	1.86632562
11	MP0001984_abnormal_olfaction	1.81588109
12	MP0000372_irregular_coat_pigmentation	1.80108599
13	MP0003195_calcinosis	1.74274361
14	MP0006292_abnormal_olfactory_placode	1.74128077
15	MP0006072_abnormal_retinal_apoptosis	1.73403246
16	MP0005174_abnormal_tail_pigmentation	1.70397452
17	MP0000427_abnormal_hair_cycle	1.69515332
18	MP0002009_preneoplasia	1.65956020
19	MP0005253_abnormal_eye_physiology	1.65300568
20	MP0009697_abnormal_copulation	1.63882882
21	MP0005551_abnormal_eye_electrophysiolog	1.62963026
22	MP0001529_abnormal_vocalization	1.62258371
23	MP0000015_abnormal_ear_pigmentation	1.60129566
24	MP0005187_abnormal_penis_morphology	1.58458608
25	MP0000516_abnormal_urinary_system	1.56062016
26	MP0005367_renal/urinary_system_phenotyp	1.56062016
27	MP0002638_abnormal_pupillary_reflex	1.53641595
28	MP0005645_abnormal_hypothalamus_physiol	1.52251806
29	MP0002938_white_spotting	1.51146388
30	MP0003786_premature_aging	1.47872098
31	MP0003880_abnormal_central_pattern	1.45785792
32	MP0008995_early_reproductive_senescence	1.45275561
33	MP0003122_maternal_imprinting	1.43703832
34	MP0000778_abnormal_nervous_system	1.43286086
35	MP0002095_abnormal_skin_pigmentation	1.40389131
36	MP0009046_muscle_twitch	1.37012062
37	MP0006276_abnormal_autonomic_nervous	1.35739232
38	MP0002751_abnormal_autonomic_nervous	1.33940582
39	MP0003937_abnormal_limbs/digits/tail_de	1.32041047
40	MP0002837_dystrophic_cardiac_calcinosis	1.31698247
41	MP0000631_abnormal_neuroendocrine_gland	1.25390507
42	MP0004885_abnormal_endolymph	1.24166707
43	MP0003718_maternal_effect	1.23364698
44	MP0004924_abnormal_behavior	1.20836538
45	MP0005386_behavior/neurological_phenoty	1.20836538
46	MP0001929_abnormal_gametogenesis	1.20656024
47	MP0002234_abnormal_pharynx_morphology	1.13615855
48	MP0000647_abnormal_sebaceous_gland	1.13522485
49	MP0001188_hyperpigmentation	1.13371579
50	MP0006054_spinal_hemorrhage	1.12903884
51	MP0005646_abnormal_pituitary_gland	1.12754188
52	MP0002160_abnormal_reproductive_system	1.10617860
53	MP0001293_anophthalmia	1.09612226
54	MP0008007_abnormal_cellular_replicative	1.09485678
55	MP0001486_abnormal_startle_reflex	1.09102531
56	MP0003077_abnormal_cell_cycle	1.04506758
57	MP0010678_abnormal_skin_adnexa	1.02547450
58	MP0003698_abnormal_male_reproductive	1.02300814
59	MP0003111_abnormal_nucleus_morphology	1.01570836
60	MP0004142_abnormal_muscle_tone	1.01162241
61	MP0003943_abnormal_hepatobiliary_system	1.01142527
62	MP0010352_gastrointestinal_tract_polyps	1.00911822
63	MP0002210_abnormal_sex_determination	1.00027107
64	MP0005075_abnormal_melanosome_morpholog	0.99236139
65	MP0003567_abnormal_fetal_cardiomyocyte	0.97751302
66	MP0003656_abnormal_erythrocyte_physiolo	0.97226171
67	MP0004215_abnormal_myocardial_fiber	0.96920363
68	MP0005391_vision/eye_phenotype	0.95362890
69	MP0002928_abnormal_bile_duct	0.94718579
70	MP0000383_abnormal_hair_follicle	0.94690813
71	MP0010307_abnormal_tumor_latency	0.91107962
72	MP0002272_abnormal_nervous_system	0.89830307
73	MP0000653_abnormal_sex_gland	0.89157341
74	MP0005084_abnormal_gallbladder_morpholo	0.88898532
75	MP0010234_abnormal_vibrissa_follicle	0.88758513
76	MP0003119_abnormal_digestive_system	0.88045181
77	MP0005220_abnormal_exocrine_pancreas	0.87816703
78	MP0002184_abnormal_innervation	0.87294538
79	MP0001324_abnormal_eye_pigmentation	0.86725255
80	MP0001145_abnormal_male_reproductive	0.84547080
81	MP0005195_abnormal_posterior_eye	0.84106870
82	MP0008775_abnormal_heart_ventricle	0.83135346
83	MP0008789_abnormal_olfactory_epithelium	0.82420718
84	MP0009745_abnormal_behavioral_response	0.82121664
85	MP0004133_heterotaxia	0.82004908
86	MP0001485_abnormal_pinna_reflex	0.81827377
87	MP0002557_abnormal_social/conspecific_i	0.81675536
88	MP0005389_reproductive_system_phenotype	0.80965524
89	MP0001286_abnormal_eye_development	0.79448662
90	MP0010386_abnormal_urinary_bladder	0.76242207
91	MP0002090_abnormal_vision	0.76158705
92	MP0002067_abnormal_sensory_capabilities	0.75399460
93	MP0001968_abnormal_touch/_nociception	0.75346696
94	MP0009703_decreased_birth_body	0.74380813
95	MP0002233_abnormal_nose_morphology	0.73775339
96	MP0005395_other_phenotype	0.73710456
97	MP0003693_abnormal_embryo_hatching	0.72981046
98	MP0004270_analgesia	0.72669724
99	MP0004134_abnormal_chest_morphology	0.72658527
100	MP0003935_abnormal_craniofacial_develop	0.71972256

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	3.58847244
2	Chronic hepatic failure (HP:0100626)	3.29663287
3	Pancreatic cysts (HP:0001737)	3.24859043
4	Pancreatic fibrosis (HP:0100732)	3.01414582
5	Molar tooth sign on MRI (HP:0002419)	2.96001788
6	Abnormality of midbrain morphology (HP:0002418)	2.96001788
7	Hyperventilation (HP:0002883)	2.93010774
8	Nephronophthisis (HP:0000090)	2.92665152
9	Abnormality of chromosome stability (HP:0003220)	2.85861693
10	Chromsome breakage (HP:0040012)	2.85455635
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.81579943
12	Medial flaring of the eyebrow (HP:0010747)	2.76525479
13	Abnormality of the renal medulla (HP:0100957)	2.73067451
14	True hermaphroditism (HP:0010459)	2.70960557
15	Abnormality of the renal cortex (HP:0011035)	2.70474589
16	Abnormality of the labia minora (HP:0012880)	2.65470140
17	Drooling (HP:0002307)	2.61086217
18	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.58028874
19	Intestinal atresia (HP:0011100)	2.57738357
20	Fair hair (HP:0002286)	2.55075500
21	Abnormality of the astrocytes (HP:0100707)	2.53795160
22	Astrocytoma (HP:0009592)	2.53795160
23	Gaze-evoked nystagmus (HP:0000640)	2.44464546
24	Neoplasm of the adrenal cortex (HP:0100641)	2.41553631
25	Glioma (HP:0009733)	2.39090073
26	Colon cancer (HP:0003003)	2.37156951
27	Protruding tongue (HP:0010808)	2.35541119
28	Hypothermia (HP:0002045)	2.32217032
29	Papillary thyroid carcinoma (HP:0002895)	2.32045197
30	Abnormality of the ileum (HP:0001549)	2.31357844
31	Excessive salivation (HP:0003781)	2.31252175
32	Broad-based gait (HP:0002136)	2.31106676
33	Aqueductal stenosis (HP:0002410)	2.30734245
34	Tubulointerstitial nephritis (HP:0001970)	2.30534788
35	Meckel diverticulum (HP:0002245)	2.30107498
36	Oligodactyly (hands) (HP:0001180)	2.21444049
37	Gait imbalance (HP:0002141)	2.18989818
38	Febrile seizures (HP:0002373)	2.18779403
39	Renal cortical cysts (HP:0000803)	2.18635267
40	Congenital primary aphakia (HP:0007707)	2.18577016
41	Thyroiditis (HP:0100646)	2.15327307
42	Genital tract atresia (HP:0001827)	2.12327287
43	Thyroid carcinoma (HP:0002890)	2.11688793
44	Sloping forehead (HP:0000340)	2.10715807
45	Submucous cleft hard palate (HP:0000176)	2.08871016
46	Widely spaced teeth (HP:0000687)	2.06942060
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06006010
48	Ependymoma (HP:0002888)	2.05190616
49	Nephrogenic diabetes insipidus (HP:0009806)	2.04106304
50	Clubbing of toes (HP:0100760)	2.02097197
51	Vaginal atresia (HP:0000148)	2.01461793
52	Absent speech (HP:0001344)	1.99074147
53	Poor coordination (HP:0002370)	1.97699583
54	Neoplasm of the oral cavity (HP:0100649)	1.96781805
55	Rhabdomyosarcoma (HP:0002859)	1.95871182
56	Abnormality of the preputium (HP:0100587)	1.95391112
57	Cupped ear (HP:0000378)	1.94852681
58	Abnormal hair whorl (HP:0010721)	1.94467143
59	Progressive inability to walk (HP:0002505)	1.90538052
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.88731611
61	Generalized hypopigmentation of hair (HP:0011358)	1.86197458
62	Hip dysplasia (HP:0001385)	1.85170923
63	Small intestinal stenosis (HP:0012848)	1.83531714
64	Duodenal stenosis (HP:0100867)	1.83531714
65	Hypoplastic iliac wings (HP:0002866)	1.82223514
66	Embryonal renal neoplasm (HP:0011794)	1.81449169
67	Postaxial foot polydactyly (HP:0001830)	1.80839221
68	Astigmatism (HP:0000483)	1.80488275
69	Abnormality of the duodenum (HP:0002246)	1.79980526
70	Ectopic kidney (HP:0000086)	1.77120987
71	Birth length less than 3rd percentile (HP:0003561)	1.76555334
72	Attenuation of retinal blood vessels (HP:0007843)	1.75083939
73	Lissencephaly (HP:0001339)	1.73589387
74	Small hand (HP:0200055)	1.72570263
75	Atonic seizures (HP:0010819)	1.72368359
76	Acute myeloid leukemia (HP:0004808)	1.69823533
77	Type II lissencephaly (HP:0007260)	1.69128006
78	Tubular atrophy (HP:0000092)	1.68829907
79	Methylmalonic acidemia (HP:0002912)	1.68091039
80	Dandy-Walker malformation (HP:0001305)	1.67956271
81	Nephroblastoma (Wilms tumor) (HP:0002667)	1.67146902
82	Genetic anticipation (HP:0003743)	1.65380537
83	Cerebellar dysplasia (HP:0007033)	1.65203389
84	Neoplasm of the small intestine (HP:0100833)	1.64986120
85	Abnormality of the metopic suture (HP:0005556)	1.64240603
86	Hypoplastic labia majora (HP:0000059)	1.63544088
87	Progressive cerebellar ataxia (HP:0002073)	1.63348949
88	Prominent nasal bridge (HP:0000426)	1.63023146
89	Abnormality of the pons (HP:0007361)	1.63019459
90	Thin upper lip vermilion (HP:0000219)	1.62949913
91	Sclerocornea (HP:0000647)	1.62827808
92	Highly arched eyebrow (HP:0002553)	1.62743700
93	Exotropia (HP:0000577)	1.62275563
94	Postaxial hand polydactyly (HP:0001162)	1.62245145
95	Duplicated collecting system (HP:0000081)	1.62179289
96	Preaxial hand polydactyly (HP:0001177)	1.61906498
97	Narrow forehead (HP:0000341)	1.61650324
98	Breast carcinoma (HP:0003002)	1.61162329
99	Abnormality of the carotid arteries (HP:0005344)	1.60622214
100	Cystic liver disease (HP:0006706)	1.60477006

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.47567518
2	WNK3	3.14923679
3	TRIM28	2.91546039
4	MKNK2	2.45200506
5	CASK	2.40807691
6	BMPR1B	2.28488774
7	MAP3K4	2.19764414
8	NUAK1	2.18495022
9	EIF2AK3	2.16019552
10	ACVR1B	2.10662571
11	ERBB3	2.10596567
12	BRSK2	2.09567184
13	BRD4	2.01965842
14	MAP4K2	1.93704020
15	AKT3	1.84761309
16	ZAK	1.80306967
17	BCR	1.77711125
18	PLK4	1.61875842
19	MAPK13	1.60330765
20	TNIK	1.56987775
21	MKNK1	1.54818956
22	PLK2	1.52407401
23	FGFR2	1.45499902
24	MARK1	1.44299918
25	WEE1	1.36166279
26	STK39	1.33760470
27	PLK3	1.25543385
28	STK38L	1.22967836
29	BUB1	1.20611527
30	PNCK	1.10812854
31	CDC7	1.08389903
32	NLK	1.06955259
33	MAP2K7	1.06532798
34	EIF2AK1	1.06380120
35	PINK1	1.06115924
36	PAK3	1.04076789
37	CSNK1G1	1.03458603
38	SRPK1	1.03397492
39	STK3	1.02612921
40	MST4	1.02304151
41	OXSR1	1.01892090
42	CAMKK2	1.01407258
43	NTRK3	0.98220442
44	ADRBK2	0.94461276
45	EPHA4	0.94006082
46	SGK2	0.88277260
47	CSNK1A1L	0.87620069
48	CSNK1G2	0.84747205
49	INSRR	0.81729424
50	GRK1	0.80751717
51	TEC	0.80544539
52	WNK4	0.77187698
53	VRK1	0.76377279
54	ATM	0.75437284
55	CAMK1G	0.75122929
56	PLK1	0.70732692
57	YES1	0.70257919
58	CSNK1G3	0.69998663
59	TSSK6	0.68921404
60	TAF1	0.67536405
61	ATR	0.67431675
62	TLK1	0.67148496
63	LATS1	0.66326208
64	SIK3	0.64656575
65	PRKCE	0.64645020
66	TTK	0.64260842
67	FER	0.63569439
68	TGFBR1	0.63308535
69	CDK3	0.61226414
70	DYRK3	0.60124899
71	TAOK3	0.59321966
72	KSR1	0.58321087
73	CHEK2	0.52827434
74	CAMK1D	0.49870394
75	DYRK1A	0.49724538
76	CCNB1	0.48655546
77	CSNK1D	0.48271883
78	TIE1	0.46840477
79	MUSK	0.46626230
80	SGK223	0.45010667
81	SGK494	0.45010667
82	RPS6KA5	0.44790932
83	NEK1	0.43231380
84	CHEK1	0.43139913
85	EIF2AK2	0.43090957
86	IRAK1	0.41988664
87	DYRK2	0.41506655
88	PRKAA1	0.41449804
89	TRPM7	0.40194636
90	PIK3CG	0.39938666
91	PRKCG	0.38832988
92	RPS6KA4	0.38444043
93	STK11	0.38183257
94	STK24	0.37184836
95	PIK3CA	0.36890259
96	PBK	0.34533068
97	PRKAA2	0.33974913
98	FGFR1	0.32675874
99	SGK3	0.32587807
100	ADRBK1	0.32302309

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.44340856
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.19574419
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.91257884
4	Basal transcription factors_Homo sapiens_hsa03022	2.71490888
5	Protein export_Homo sapiens_hsa03060	2.68646885
6	Homologous recombination_Homo sapiens_hsa03440	2.48483065
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.32024623
8	Nicotine addiction_Homo sapiens_hsa05033	2.12515420
9	Butanoate metabolism_Homo sapiens_hsa00650	2.08500480
10	RNA degradation_Homo sapiens_hsa03018	1.99980342
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.98450756
12	Circadian rhythm_Homo sapiens_hsa04710	1.90418243
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90137343
14	Phototransduction_Homo sapiens_hsa04744	1.84849206
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.77247577
16	Propanoate metabolism_Homo sapiens_hsa00640	1.72974697
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.68865476
18	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.63190471
19	RNA transport_Homo sapiens_hsa03013	1.58276974
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.56539296
21	Mismatch repair_Homo sapiens_hsa03430	1.53747995
22	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.46706754
23	Cell cycle_Homo sapiens_hsa04110	1.46686068
24	Regulation of autophagy_Homo sapiens_hsa04140	1.46632846
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.45381470
26	Taste transduction_Homo sapiens_hsa04742	1.41862647
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.38261655
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.35953781
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.34715897
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33712501
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.32858659
32	Alcoholism_Homo sapiens_hsa05034	1.31050030
33	RNA polymerase_Homo sapiens_hsa03020	1.30753859
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28835337
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.22638869
36	Steroid biosynthesis_Homo sapiens_hsa00100	1.21283840
37	mRNA surveillance pathway_Homo sapiens_hsa03015	1.19588879
38	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.19101343
39	Oocyte meiosis_Homo sapiens_hsa04114	1.15455041
40	One carbon pool by folate_Homo sapiens_hsa00670	1.11638295
41	Lysine degradation_Homo sapiens_hsa00310	1.10342475
42	p53 signaling pathway_Homo sapiens_hsa04115	1.10038580
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.07037097
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95216472
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.91212008
46	GABAergic synapse_Homo sapiens_hsa04727	0.90152437
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87736219
48	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.87520226
49	Circadian entrainment_Homo sapiens_hsa04713	0.87473663
50	ABC transporters_Homo sapiens_hsa02010	0.87369752
51	Olfactory transduction_Homo sapiens_hsa04740	0.87125529
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.86280201
53	Morphine addiction_Homo sapiens_hsa05032	0.84445560
54	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.82034184
55	Serotonergic synapse_Homo sapiens_hsa04726	0.79817131
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.79664236
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78756483
58	Long-term depression_Homo sapiens_hsa04730	0.77898323
59	Spliceosome_Homo sapiens_hsa03040	0.77471039
60	Insulin secretion_Homo sapiens_hsa04911	0.77292996
61	Amphetamine addiction_Homo sapiens_hsa05031	0.74450037
62	FoxO signaling pathway_Homo sapiens_hsa04068	0.71280483
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.70436233
64	Purine metabolism_Homo sapiens_hsa00230	0.70216332
65	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.65803489
66	Peroxisome_Homo sapiens_hsa04146	0.64743002
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64421105
68	DNA replication_Homo sapiens_hsa03030	0.63250526
69	Hippo signaling pathway_Homo sapiens_hsa04390	0.60434158
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58516691
71	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.56167874
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55405323
73	Caffeine metabolism_Homo sapiens_hsa00232	0.53958296
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53755404
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53703901
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51868866
77	MicroRNAs in cancer_Homo sapiens_hsa05206	0.51141189
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.49596047
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49391064
80	Melanoma_Homo sapiens_hsa05218	0.49372821
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48726282
82	Type II diabetes mellitus_Homo sapiens_hsa04930	0.48110638
83	Colorectal cancer_Homo sapiens_hsa05210	0.48042818
84	Sulfur metabolism_Homo sapiens_hsa00920	0.47574622
85	Cocaine addiction_Homo sapiens_hsa05030	0.43132700
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43090102
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.42927378
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.42631480
89	Cholinergic synapse_Homo sapiens_hsa04725	0.42575391
90	Renin secretion_Homo sapiens_hsa04924	0.40363859
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38976387
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38199316
93	mTOR signaling pathway_Homo sapiens_hsa04150	0.37919178
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.37212567
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.36424740
96	Axon guidance_Homo sapiens_hsa04360	0.36291173
97	Prostate cancer_Homo sapiens_hsa05215	0.32956573
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29473365
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.28708822
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.27901035

ZNF451

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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