ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	5.16991641
2	pyrimidine nucleobase catabolic process (GO:0006208)	5.02726977
3	behavioral response to nicotine (GO:0035095)	4.51725846
4	presynaptic membrane assembly (GO:0097105)	4.42677955
5	nucleobase catabolic process (GO:0046113)	4.16823103
6	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.06808253
7	proline transport (GO:0015824)	3.95174678
8	presynaptic membrane organization (GO:0097090)	3.94274577
9	transmission of nerve impulse (GO:0019226)	3.77209535
10	protein-cofactor linkage (GO:0018065)	3.73965299
11	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.73285441
12	postsynaptic membrane organization (GO:0001941)	3.67128841
13	neuron cell-cell adhesion (GO:0007158)	3.63302978
14	negative regulation of telomere maintenance (GO:0032205)	3.62844280
15	L-fucose catabolic process (GO:0042355)	3.62194861
16	fucose catabolic process (GO:0019317)	3.62194861
17	L-fucose metabolic process (GO:0042354)	3.62194861
18	vocalization behavior (GO:0071625)	3.55735726
19	regulation of action potential (GO:0098900)	3.50016963
20	negative regulation of multicellular organism growth (GO:0040015)	3.45629155
21	nonmotile primary cilium assembly (GO:0035058)	3.45522415
22	protein polyglutamylation (GO:0018095)	3.41236499
23	kynurenine metabolic process (GO:0070189)	3.25520746
24	axoneme assembly (GO:0035082)	3.25150910
25	regulation of memory T cell differentiation (GO:0043380)	3.23330991
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.22354637
27	regulation of collateral sprouting (GO:0048670)	3.21249748
28	synaptic transmission, cholinergic (GO:0007271)	3.17996763
29	regulation of development, heterochronic (GO:0040034)	3.12257870
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.11638607
31	regulation of timing of cell differentiation (GO:0048505)	3.11197081
32	response to pheromone (GO:0019236)	3.08460299
33	establishment of mitochondrion localization (GO:0051654)	3.07263797
34	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.04517959
35	protein localization to synapse (GO:0035418)	3.04292509
36	regulation of telomere maintenance (GO:0032204)	3.03691134
37	startle response (GO:0001964)	3.02302254
38	epithelial cilium movement (GO:0003351)	3.02288471
39	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.02073992
40	indole-containing compound catabolic process (GO:0042436)	2.99971091
41	indolalkylamine catabolic process (GO:0046218)	2.99971091
42	tryptophan catabolic process (GO:0006569)	2.99971091
43	cerebellar Purkinje cell differentiation (GO:0021702)	2.98422440
44	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.93599664
45	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.92915172
46	neuronal action potential propagation (GO:0019227)	2.90443713
47	sex differentiation (GO:0007548)	2.86546679
48	detection of light stimulus involved in sensory perception (GO:0050962)	2.85967121
49	detection of light stimulus involved in visual perception (GO:0050908)	2.85967121
50	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.77977817
51	neurotransmitter-gated ion channel clustering (GO:0072578)	2.76299734
52	glutamate receptor signaling pathway (GO:0007215)	2.75891560
53	synapse assembly (GO:0007416)	2.75848932
54	synaptic vesicle maturation (GO:0016188)	2.74968741
55	protein localization to cilium (GO:0061512)	2.74614380
56	neuronal action potential (GO:0019228)	2.72095836
57	tryptophan metabolic process (GO:0006568)	2.71588275
58	indolalkylamine metabolic process (GO:0006586)	2.71323784
59	synaptic transmission, glutamatergic (GO:0035249)	2.69413083
60	behavioral response to ethanol (GO:0048149)	2.67995990
61	retinal cone cell development (GO:0046549)	2.67636736
62	cellular ketone body metabolic process (GO:0046950)	2.66117064
63	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.65774938
64	adult walking behavior (GO:0007628)	2.64105141
65	inner ear receptor stereocilium organization (GO:0060122)	2.61493627
66	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.61086869
67	olfactory bulb development (GO:0021772)	2.59439897
68	C4-dicarboxylate transport (GO:0015740)	2.59121845
69	cilium movement (GO:0003341)	2.58644406
70	photoreceptor cell maintenance (GO:0045494)	2.54849226
71	intraciliary transport (GO:0042073)	2.54830306
72	ubiquinone metabolic process (GO:0006743)	2.53841237
73	cilium morphogenesis (GO:0060271)	2.52159015
74	reflex (GO:0060004)	2.51928630
75	cellular biogenic amine catabolic process (GO:0042402)	2.50834293
76	amine catabolic process (GO:0009310)	2.50834293
77	central nervous system projection neuron axonogenesis (GO:0021952)	2.50577797
78	seminiferous tubule development (GO:0072520)	2.50533855
79	regulation of cilium movement (GO:0003352)	2.49812171
80	cell proliferation in forebrain (GO:0021846)	2.47379968
81	regulation of sarcomere organization (GO:0060297)	2.46756632
82	glycosphingolipid biosynthetic process (GO:0006688)	2.46669440
83	neural tube formation (GO:0001841)	2.45809416
84	regulation of translation, ncRNA-mediated (GO:0045974)	2.44743455
85	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.44743455
86	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.44743455
87	positive regulation of action potential (GO:0045760)	2.44573069
88	auditory receptor cell stereocilium organization (GO:0060088)	2.44558934
89	tachykinin receptor signaling pathway (GO:0007217)	2.44428504
90	positive regulation of synapse assembly (GO:0051965)	2.44106990
91	photoreceptor cell development (GO:0042461)	2.43043467
92	head development (GO:0060322)	2.41367183
93	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.41004443
94	substrate-independent telencephalic tangential migration (GO:0021826)	2.41004443
95	alanine transport (GO:0032328)	2.40851865
96	cilium organization (GO:0044782)	2.40811358
97	negative regulation of mast cell activation (GO:0033004)	2.39025350
98	limb bud formation (GO:0060174)	2.36870860
99	cilium assembly (GO:0042384)	2.36758591
100	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.35819898

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.74237657
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.61190865
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.27951310
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.15024194
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.14596901
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.88965260
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.85142963
8	VDR_22108803_ChIP-Seq_LS180_Human	2.83651486
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54503792
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.47909627
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.41749041
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.34608996
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30678971
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.29753196
15	FUS_26573619_Chip-Seq_HEK293_Human	2.26684203
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.24898877
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01490214
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93638868
19	P300_19829295_ChIP-Seq_ESCs_Human	1.93063189
20	EWS_26573619_Chip-Seq_HEK293_Human	1.89739928
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.77044278
22	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.75929013
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.74747809
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73319280
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.70940486
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68433753
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67048316
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58501013
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.58294315
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.57511305
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57304051
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56049068
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55418359
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53768563
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53544009
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53399002
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52001759
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51974333
39	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.51963651
40	AR_25329375_ChIP-Seq_VCAP_Human	1.46576601
41	STAT3_23295773_ChIP-Seq_U87_Human	1.45555476
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44483690
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.41889784
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41889784
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41504739
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41195133
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40892477
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37686345
49	TCF4_23295773_ChIP-Seq_U87_Human	1.36016020
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35630731
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35576912
52	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.35093967
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.32271953
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31973190
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30968889
56	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30257401
57	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29880733
58	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.26220891
59	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.25783038
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23108185
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.20975659
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20634837
63	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.20225300
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17742294
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17536738
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17536738
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15766133
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13945122
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12251905
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11850501
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11588710
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11519541
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10716715
74	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08834034
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08038660
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07841922
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07841922
78	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.07407130
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.07397136
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07090577
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06277482
82	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.06158261
83	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03678774
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02713141
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00971836
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98982493
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98982493
88	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98233651
89	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98173624
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96550044
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96061514
92	JUN_21703547_ChIP-Seq_K562_Human	0.96048863
93	KDM2B_26808549_Chip-Seq_REH_Human	0.95661414
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94614581
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94562021
96	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.94436568
97	NCOR_22424771_ChIP-Seq_293T_Human	0.93663143
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92889671
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.92557524
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.91979996

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.14627981
2	MP0001968_abnormal_touch/_nociception	3.09703338
3	MP0001529_abnormal_vocalization	2.95572020
4	MP0008877_abnormal_DNA_methylation	2.82344748
5	MP0003011_delayed_dark_adaptation	2.62025016
6	MP0001986_abnormal_taste_sensitivity	2.50138341
7	MP0002638_abnormal_pupillary_reflex	2.46783595
8	MP0001188_hyperpigmentation	2.31744664
9	MP0003880_abnormal_central_pattern	2.30672664
10	MP0009046_muscle_twitch	2.18039023
11	MP0009745_abnormal_behavioral_response	2.16730297
12	MP0005551_abnormal_eye_electrophysiolog	2.11984285
13	MP0002102_abnormal_ear_morphology	2.08696042
14	MP0005253_abnormal_eye_physiology	2.08312098
15	MP0006276_abnormal_autonomic_nervous	2.07847571
16	MP0004859_abnormal_synaptic_plasticity	2.07498126
17	MP0002272_abnormal_nervous_system	2.06833048
18	MP0000569_abnormal_digit_pigmentation	2.06486662
19	MP0006072_abnormal_retinal_apoptosis	2.02561539
20	MP0003635_abnormal_synaptic_transmissio	2.00755982
21	MP0001486_abnormal_startle_reflex	1.98129178
22	MP0000778_abnormal_nervous_system	1.82761484
23	MP0004885_abnormal_endolymph	1.81173606
24	MP0006292_abnormal_olfactory_placode	1.80751557
25	MP0003787_abnormal_imprinting	1.79915290
26	MP0002653_abnormal_ependyma_morphology	1.78580970
27	MP0002572_abnormal_emotion/affect_behav	1.72848613
28	MP0002734_abnormal_mechanical_nocicepti	1.65212944
29	MP0002063_abnormal_learning/memory/cond	1.63738207
30	MP0002735_abnormal_chemical_nociception	1.60262646
31	MP0008789_abnormal_olfactory_epithelium	1.59611531
32	MP0005084_abnormal_gallbladder_morpholo	1.59023675
33	MP0004043_abnormal_pH_regulation	1.58197339
34	MP0001984_abnormal_olfaction	1.57689826
35	MP0004270_analgesia	1.57268483
36	MP0002733_abnormal_thermal_nociception	1.56350060
37	MP0002064_seizures	1.55045860
38	MP0004924_abnormal_behavior	1.52886434
39	MP0005386_behavior/neurological_phenoty	1.52886434
40	MP0003122_maternal_imprinting	1.50220930
41	MP0005499_abnormal_olfactory_system	1.50001460
42	MP0005394_taste/olfaction_phenotype	1.50001460
43	MP0001970_abnormal_pain_threshold	1.48281747
44	MP0001501_abnormal_sleep_pattern	1.45761809
45	MP0004142_abnormal_muscle_tone	1.41382260
46	MP0000631_abnormal_neuroendocrine_gland	1.39815968
47	MP0002557_abnormal_social/conspecific_i	1.39190324
48	MP0002067_abnormal_sensory_capabilities	1.35789806
49	MP0002938_white_spotting	1.31693118
50	MP0003195_calcinosis	1.26627113
51	MP0003567_abnormal_fetal_cardiomyocyte	1.24816784
52	MP0005367_renal/urinary_system_phenotyp	1.21770736
53	MP0000516_abnormal_urinary_system	1.21770736
54	MP0000049_abnormal_middle_ear	1.19848145
55	MP0004133_heterotaxia	1.18838589
56	MP0000427_abnormal_hair_cycle	1.17989000
57	MP0002837_dystrophic_cardiac_calcinosis	1.17348565
58	MP0004147_increased_porphyrin_level	1.15538587
59	MP0002752_abnormal_somatic_nervous	1.14320322
60	MP0001905_abnormal_dopamine_level	1.13917681
61	MP0003137_abnormal_impulse_conducting	1.10852550
62	MP0003119_abnormal_digestive_system	1.09530413
63	MP0008872_abnormal_physiological_respon	1.08858614
64	MP0003121_genomic_imprinting	1.08700781
65	MP0002184_abnormal_innervation	1.08698033
66	MP0002882_abnormal_neuron_morphology	1.05758286
67	MP0000955_abnormal_spinal_cord	1.04664732
68	MP0004811_abnormal_neuron_physiology	1.04203452
69	MP0002751_abnormal_autonomic_nervous	1.03664577
70	MP0005646_abnormal_pituitary_gland	1.03008961
71	MP0008058_abnormal_DNA_repair	1.01647763
72	MP0001485_abnormal_pinna_reflex	1.01375105
73	MP0000372_irregular_coat_pigmentation	0.99843973
74	MP0005423_abnormal_somatic_nervous	0.99644769
75	MP0005391_vision/eye_phenotype	0.98290985
76	MP0004742_abnormal_vestibular_system	0.97586625
77	MP0005195_abnormal_posterior_eye	0.96270127
78	MP0003718_maternal_effect	0.95189603
79	MP0002277_abnormal_respiratory_mucosa	0.94325898
80	MP0002069_abnormal_eating/drinking_beha	0.91702605
81	MP0002234_abnormal_pharynx_morphology	0.91633515
82	MP0001963_abnormal_hearing_physiology	0.91154566
83	MP0001502_abnormal_circadian_rhythm	0.89952303
84	MP0000026_abnormal_inner_ear	0.89791233
85	MP0010386_abnormal_urinary_bladder	0.88892886
86	MP0001177_atelectasis	0.87691164
87	MP0002066_abnormal_motor_capabilities/c	0.87406837
88	MP0008875_abnormal_xenobiotic_pharmacok	0.87348499
89	MP0003136_yellow_coat_color	0.86971862
90	MP0003252_abnormal_bile_duct	0.86198310
91	MP0002229_neurodegeneration	0.85604241
92	MP0002152_abnormal_brain_morphology	0.84125207
93	MP0002876_abnormal_thyroid_physiology	0.83824927
94	MP0001440_abnormal_grooming_behavior	0.82868135
95	MP0002233_abnormal_nose_morphology	0.81254946
96	MP0003890_abnormal_embryonic-extraembry	0.80328076
97	MP0005645_abnormal_hypothalamus_physiol	0.78762816
98	MP0004085_abnormal_heartbeat	0.78227358
99	MP0003861_abnormal_nervous_system	0.77356101
100	MP0004215_abnormal_myocardial_fiber	0.76218662

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pendular nystagmus (HP:0012043)	3.85978496
2	Pancreatic fibrosis (HP:0100732)	3.68375244
3	Pancreatic cysts (HP:0001737)	3.67751495
4	Hyperventilation (HP:0002883)	3.64903685
5	Genetic anticipation (HP:0003743)	3.41527828
6	Progressive cerebellar ataxia (HP:0002073)	3.37760082
7	True hermaphroditism (HP:0010459)	3.26946713
8	Action tremor (HP:0002345)	3.23600307
9	Medial flaring of the eyebrow (HP:0010747)	3.21906473
10	Abnormality of midbrain morphology (HP:0002418)	3.14088049
11	Molar tooth sign on MRI (HP:0002419)	3.14088049
12	Gait imbalance (HP:0002141)	3.01588476
13	Focal seizures (HP:0007359)	3.00994113
14	Focal motor seizures (HP:0011153)	2.97367176
15	Dialeptic seizures (HP:0011146)	2.89334513
16	Absent speech (HP:0001344)	2.85279462
17	Gaze-evoked nystagmus (HP:0000640)	2.76880855
18	Nephronophthisis (HP:0000090)	2.75792081
19	Hyperglycinemia (HP:0002154)	2.74730489
20	Drooling (HP:0002307)	2.74192542
21	Abnormality of the labia minora (HP:0012880)	2.72132907
22	Lissencephaly (HP:0001339)	2.71123664
23	Congenital primary aphakia (HP:0007707)	2.68741133
24	Hypsarrhythmia (HP:0002521)	2.66097783
25	Abolished electroretinogram (ERG) (HP:0000550)	2.63170473
26	Inability to walk (HP:0002540)	2.56592687
27	Congenital stationary night blindness (HP:0007642)	2.55310389
28	EEG with generalized epileptiform discharges (HP:0011198)	2.53524738
29	Broad-based gait (HP:0002136)	2.52170035
30	Febrile seizures (HP:0002373)	2.51288603
31	Type II lissencephaly (HP:0007260)	2.51128340
32	Absence seizures (HP:0002121)	2.50337314
33	Excessive salivation (HP:0003781)	2.47159569
34	Limb dystonia (HP:0002451)	2.46772316
35	Epileptiform EEG discharges (HP:0011182)	2.43958253
36	Nephrogenic diabetes insipidus (HP:0009806)	2.43929290
37	Tubulointerstitial nephritis (HP:0001970)	2.39250460
38	Abnormality of the renal medulla (HP:0100957)	2.38352068
39	Polyphagia (HP:0002591)	2.37412067
40	Genital tract atresia (HP:0001827)	2.35001943
41	Abnormality of the renal cortex (HP:0011035)	2.33197198
42	Epileptic encephalopathy (HP:0200134)	2.28763016
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.27022947
44	Pachygyria (HP:0001302)	2.25724353
45	Increased corneal curvature (HP:0100692)	2.25290512
46	Keratoconus (HP:0000563)	2.25290512
47	Vaginal atresia (HP:0000148)	2.24936891
48	Cystic liver disease (HP:0006706)	2.22791111
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.22773411
50	Absent/shortened dynein arms (HP:0200106)	2.22773411
51	Hyperglycinuria (HP:0003108)	2.18808143
52	Hemiparesis (HP:0001269)	2.17831124
53	Retinal dysplasia (HP:0007973)	2.17652723
54	Methylmalonic acidemia (HP:0002912)	2.15818252
55	Narrow forehead (HP:0000341)	2.12345939
56	Postaxial foot polydactyly (HP:0001830)	2.10198117
57	Chronic hepatic failure (HP:0100626)	2.08218765
58	Chorioretinal atrophy (HP:0000533)	2.07497717
59	Postaxial hand polydactyly (HP:0001162)	2.06952890
60	Tubular atrophy (HP:0000092)	2.05886760
61	Atonic seizures (HP:0010819)	2.03724213
62	Urinary bladder sphincter dysfunction (HP:0002839)	2.03101922
63	Sclerocornea (HP:0000647)	2.02149378
64	Spastic tetraplegia (HP:0002510)	2.01981615
65	Short tibia (HP:0005736)	2.01878150
66	Protruding tongue (HP:0010808)	2.01690629
67	Progressive inability to walk (HP:0002505)	2.00680559
68	Dysdiadochokinesis (HP:0002075)	2.00191479
69	Cerebellar dysplasia (HP:0007033)	1.99638881
70	Abnormality of glycine metabolism (HP:0010895)	1.98779701
71	Abnormality of serine family amino acid metabolism (HP:0010894)	1.98779701
72	Abnormal drinking behavior (HP:0030082)	1.98681380
73	Polydipsia (HP:0001959)	1.98681380
74	Cortical dysplasia (HP:0002539)	1.98017514
75	Abnormality of macular pigmentation (HP:0008002)	1.96948050
76	Specific learning disability (HP:0001328)	1.95453219
77	Generalized myoclonic seizures (HP:0002123)	1.92721531
78	Congenital hepatic fibrosis (HP:0002612)	1.91938207
79	Anencephaly (HP:0002323)	1.89598056
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88390857
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.88390857
82	Oculomotor apraxia (HP:0000657)	1.87049810
83	Supernumerary spleens (HP:0009799)	1.86274605
84	Male pseudohermaphroditism (HP:0000037)	1.86236953
85	Myokymia (HP:0002411)	1.86056698
86	Optic nerve hypoplasia (HP:0000609)	1.85673681
87	Retinitis pigmentosa (HP:0000510)	1.84704887
88	Attenuation of retinal blood vessels (HP:0007843)	1.84626073
89	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.83824886
90	Polymicrogyria (HP:0002126)	1.82071489
91	Abnormal ciliary motility (HP:0012262)	1.82024574
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81519785
93	Bony spicule pigmentary retinopathy (HP:0007737)	1.80693291
94	Renal cortical cysts (HP:0000803)	1.80668149
95	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78933284
96	Short foot (HP:0001773)	1.78125570
97	Acute encephalopathy (HP:0006846)	1.77869502
98	Poor eye contact (HP:0000817)	1.76487927
99	Muscular hypotonia of the trunk (HP:0008936)	1.75785685
100	Poor coordination (HP:0002370)	1.75754933

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.90713103
2	WNK3	3.80684274
3	MARK1	3.56167332
4	MAPK13	3.24141719
5	CDK19	3.19136323
6	CASK	2.95441201
7	MAP3K4	2.88413251
8	GRK1	2.59429213
9	MAP2K7	2.38975846
10	MAP4K2	2.38268089
11	BMPR1B	2.18841838
12	TRIM28	2.07140490
13	PINK1	2.06681450
14	ADRBK2	2.01631476
15	NUAK1	1.94885453
16	OXSR1	1.94582096
17	TNIK	1.92711611
18	AKT3	1.87392219
19	DYRK2	1.83920613
20	BCR	1.60747394
21	PNCK	1.52523788
22	NTRK2	1.47462298
23	PRKCG	1.35483350
24	CSNK1G2	1.35040331
25	TIE1	1.34995201
26	MKNK2	1.32993659
27	STK16	1.32811174
28	INSRR	1.31159939
29	CSNK1G3	1.29172462
30	CSNK1A1L	1.27506050
31	PRKCE	1.24212912
32	CSNK1G1	1.23732795
33	ZAK	1.16293636
34	PLK2	1.15660749
35	BCKDK	1.15033324
36	PRKD3	1.14928483
37	MAP2K4	1.09589082
38	PKN1	1.09581957
39	PAK3	1.08132525
40	CCNB1	1.06732003
41	DAPK2	1.02817296
42	ERBB3	0.96635075
43	MKNK1	0.84938701
44	SGK223	0.80787353
45	SGK494	0.80787353
46	SGK2	0.80407010
47	DYRK1A	0.78353244
48	EPHA4	0.78136353
49	WNK4	0.77996583
50	PHKG2	0.77422558
51	PHKG1	0.77422558
52	STK38L	0.74046929
53	TLK1	0.72701282
54	DYRK3	0.68107961
55	SRPK1	0.65378225
56	NTRK3	0.64098988
57	CAMK2A	0.61836064
58	TXK	0.58541696
59	VRK1	0.57675295
60	FGFR2	0.57643634
61	PLK3	0.56961428
62	PRKCZ	0.56532379
63	UHMK1	0.54686545
64	PTK2B	0.54446375
65	CDK5	0.50959004
66	PRKACA	0.49956778
67	CSNK1D	0.48299490
68	ADRBK1	0.47524193
69	CSNK1A1	0.47083107
70	FER	0.46807081
71	EPHA3	0.46636021
72	CAMK2B	0.46441811
73	LIMK1	0.46170853
74	TGFBR1	0.45304004
75	TAOK3	0.43261997
76	PRKAA1	0.41429706
77	MAP3K6	0.40059148
78	RPS6KA4	0.39922913
79	TSSK6	0.39873264
80	PRKG1	0.39729722
81	STK38	0.39486566
82	TNK2	0.38063529
83	CAMK2D	0.37085038
84	WEE1	0.36897537
85	MINK1	0.36570291
86	GRK5	0.36569784
87	CAMK4	0.36389083
88	ACVR1B	0.36297150
89	MAP3K9	0.36286293
90	DAPK1	0.36054611
91	CAMKK2	0.34952137
92	CDK9	0.34662174
93	CSNK1E	0.34185531
94	PLK4	0.34085577
95	STK11	0.31415589
96	PAK6	0.29624881
97	TAF1	0.28284248
98	PRKCB	0.27593802
99	PRKCA	0.26711815
100	EPHB2	0.26514002

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.20490198
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.15445666
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95038741
4	Phototransduction_Homo sapiens_hsa04744	2.57771910
5	Butanoate metabolism_Homo sapiens_hsa00650	2.37359994
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.33784763
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.19806921
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.15660613
9	Propanoate metabolism_Homo sapiens_hsa00640	2.15449902
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.11091057
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96415991
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88306432
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.81440400
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.80849676
15	Morphine addiction_Homo sapiens_hsa05032	1.74809630
16	GABAergic synapse_Homo sapiens_hsa04727	1.74734067
17	RNA polymerase_Homo sapiens_hsa03020	1.70481365
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.68739397
19	Taste transduction_Homo sapiens_hsa04742	1.65015716
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.62118850
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.60722302
22	Protein export_Homo sapiens_hsa03060	1.57213574
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.57029976
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.56915838
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.53075820
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.52128073
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.50090148
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.47319806
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.46041630
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.40514731
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.37562946
32	Basal transcription factors_Homo sapiens_hsa03022	1.34996786
33	Olfactory transduction_Homo sapiens_hsa04740	1.32392025
34	Circadian entrainment_Homo sapiens_hsa04713	1.31580886
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20259998
36	Caffeine metabolism_Homo sapiens_hsa00232	1.19407284
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18662257
38	Regulation of autophagy_Homo sapiens_hsa04140	1.16916682
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16281120
40	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.15752121
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.14195730
42	Retinol metabolism_Homo sapiens_hsa00830	1.13021091
43	Homologous recombination_Homo sapiens_hsa03440	1.11404247
44	Parkinsons disease_Homo sapiens_hsa05012	1.10152437
45	Long-term depression_Homo sapiens_hsa04730	1.09115909
46	Dopaminergic synapse_Homo sapiens_hsa04728	1.08573352
47	Serotonergic synapse_Homo sapiens_hsa04726	1.01816883
48	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01132273
49	Insulin secretion_Homo sapiens_hsa04911	0.99698421
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97127223
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96812201
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92550911
53	Peroxisome_Homo sapiens_hsa04146	0.92508460
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86227196
55	RNA degradation_Homo sapiens_hsa03018	0.83449718
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82115942
57	Cocaine addiction_Homo sapiens_hsa05030	0.81840050
58	Axon guidance_Homo sapiens_hsa04360	0.81184050
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78874348
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75944449
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73582047
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73500880
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73311734
64	Fatty acid degradation_Homo sapiens_hsa00071	0.72706968
65	Circadian rhythm_Homo sapiens_hsa04710	0.72480848
66	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71138507
67	Amphetamine addiction_Homo sapiens_hsa05031	0.70844280
68	Huntingtons disease_Homo sapiens_hsa05016	0.68582031
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.67354820
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65378022
71	Histidine metabolism_Homo sapiens_hsa00340	0.64187509
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62857824
73	Purine metabolism_Homo sapiens_hsa00230	0.62590095
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.61351167
75	Salivary secretion_Homo sapiens_hsa04970	0.60558751
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58516037
77	Metabolic pathways_Homo sapiens_hsa01100	0.57965182
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.55803636
79	Alzheimers disease_Homo sapiens_hsa05010	0.54149940
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53625753
81	ABC transporters_Homo sapiens_hsa02010	0.53257426
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.53112783
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52899573
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51509958
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45862860
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45089133
87	Renin-angiotensin system_Homo sapiens_hsa04614	0.44497040
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.43191025
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42478269
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.42389173
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.42172928
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.40493497
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.40201352
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39700548
95	Cholinergic synapse_Homo sapiens_hsa04725	0.39462659
96	Fatty acid elongation_Homo sapiens_hsa00062	0.38922494
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38499462
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34442113
99	Lysine degradation_Homo sapiens_hsa00310	0.34177762
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34072667

ZNF454

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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