ZNF460

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.42857196
2nuclear pore organization (GO:0006999)5.00602284
3cytoplasmic mRNA processing body assembly (GO:0033962)4.10281531
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.01542293
5pore complex assembly (GO:0046931)3.98284130
6establishment of protein localization to Golgi (GO:0072600)3.97276808
7monoubiquitinated protein deubiquitination (GO:0035520)3.85594796
8mitotic sister chromatid cohesion (GO:0007064)3.83734655
9microtubule anchoring (GO:0034453)3.68355903
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.67712841
11regulation of translation, ncRNA-mediated (GO:0045974)3.67712841
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.67712841
13protein K11-linked deubiquitination (GO:0035871)3.60068248
14histone mRNA catabolic process (GO:0071044)3.58470878
15protein targeting to Golgi (GO:0000042)3.51734179
16retrograde transport, vesicle recycling within Golgi (GO:0000301)3.46979729
17prenylation (GO:0097354)3.35660547
18protein prenylation (GO:0018342)3.35660547
19positive regulation of developmental pigmentation (GO:0048087)3.29719371
20interkinetic nuclear migration (GO:0022027)3.28203357
21pyrimidine dimer repair (GO:0006290)3.26027374
22snRNA transcription (GO:0009301)3.25338807
23pre-miRNA processing (GO:0031054)3.24595866
24DNA double-strand break processing (GO:0000729)3.21220982
25nucleus localization (GO:0051647)3.19349898
26histone H3-K4 trimethylation (GO:0080182)3.19328954
27DNA integration (GO:0015074)3.17943436
28neural tube formation (GO:0001841)3.16489322
29gastrulation with mouth forming second (GO:0001702)3.15252437
30fibroblast migration (GO:0010761)3.14231205
31peptidyl-lysine trimethylation (GO:0018023)3.13492121
32presynaptic membrane assembly (GO:0097105)3.06460202
33regulation of pigment cell differentiation (GO:0050932)3.05948824
34establishment of nucleus localization (GO:0040023)3.05644178
35interleukin-6-mediated signaling pathway (GO:0070102)2.96989731
36protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.93642599
37dosage compensation (GO:0007549)2.93626254
38regulation of centriole replication (GO:0046599)2.89189758
39regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.88794498
40Golgi to endosome transport (GO:0006895)2.88793545
41atrial cardiac muscle cell action potential (GO:0086014)2.87444341
42cellular response to ethanol (GO:0071361)2.82640286
43negative regulation of DNA repair (GO:0045738)2.81186472
44protein K48-linked deubiquitination (GO:0071108)2.77982325
45non-recombinational repair (GO:0000726)2.68333422
46double-strand break repair via nonhomologous end joining (GO:0006303)2.68333422
47negative regulation of DNA recombination (GO:0045910)2.67881413
48peptidyl-lysine methylation (GO:0018022)2.67355983
49pyrimidine nucleobase catabolic process (GO:0006208)2.66386153
50central nervous system neuron axonogenesis (GO:0021955)2.66369204
51dorsal/ventral axis specification (GO:0009950)2.66277170
52translesion synthesis (GO:0019985)2.64747530
53olfactory bulb development (GO:0021772)2.64386625
54regulation of hippo signaling (GO:0035330)2.63996434
55protein localization to Golgi apparatus (GO:0034067)2.62906622
56negative regulation of neurotransmitter transport (GO:0051589)2.62206829
57negative regulation of neurotransmitter secretion (GO:0046929)2.60908202
58appendage development (GO:0048736)2.59044984
59limb development (GO:0060173)2.59044984
60negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58346909
61regulation of transforming growth factor beta2 production (GO:0032909)2.57459065
62response to pheromone (GO:0019236)2.56507655
63keratinocyte development (GO:0003334)2.55380345
64regulation of sarcomere organization (GO:0060297)2.53046571
65negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.49337744
66acrosome assembly (GO:0001675)2.48350530
67genitalia morphogenesis (GO:0035112)2.48127112
68intra-Golgi vesicle-mediated transport (GO:0006891)2.47499026
69postreplication repair (GO:0006301)2.46595020
70presynaptic membrane organization (GO:0097090)2.46433628
71regulation of protein polyubiquitination (GO:1902914)2.46305250
72central nervous system projection neuron axonogenesis (GO:0021952)2.43511264
73positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.42312261
74microtubule nucleation (GO:0007020)2.41151614
75regulation of centrosome duplication (GO:0010824)2.40661149
76regulation of helicase activity (GO:0051095)2.40351090
77RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39054587
78replicative senescence (GO:0090399)2.36563652
79lipid translocation (GO:0034204)2.33966832
80phospholipid translocation (GO:0045332)2.33966832
81histone H3-K36 demethylation (GO:0070544)2.31837736
82inositol metabolic process (GO:0006020)2.31566910
83UDP-N-acetylglucosamine metabolic process (GO:0006047)2.30346201
84oocyte development (GO:0048599)2.30188872
85cellular response to sterol (GO:0036315)2.26997034
86regulation of NFAT protein import into nucleus (GO:0051532)2.25932475
87sister chromatid cohesion (GO:0007062)2.25929765
88early endosome to late endosome transport (GO:0045022)2.25367986
89regulation of RNA export from nucleus (GO:0046831)2.25201678
90androgen receptor signaling pathway (GO:0030521)2.22758965
91regulation of establishment of cell polarity (GO:2000114)2.22645013
92morphogenesis of an epithelial sheet (GO:0002011)2.21922637
93mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.20342705
94positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.20342705
95regulation of acyl-CoA biosynthetic process (GO:0050812)2.18971042
96COPII vesicle coating (GO:0048208)2.18917761
97regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.18751562
98histone lysine methylation (GO:0034968)2.18413606
99cerebellar Purkinje cell differentiation (GO:0021702)2.17569260
100regulation of chemokine-mediated signaling pathway (GO:0070099)2.16298647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.97253468
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.84718579
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.45862483
4GBX2_23144817_ChIP-Seq_PC3_Human3.43263869
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.30513009
6IGF1R_20145208_ChIP-Seq_DFB_Human3.03479242
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95354336
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55154198
9TAF15_26573619_Chip-Seq_HEK293_Human2.50283060
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39396627
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.30220641
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.29856570
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.27928188
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18711207
15FUS_26573619_Chip-Seq_HEK293_Human2.17446194
16* ZNF274_21170338_ChIP-Seq_K562_Hela2.06454227
17EWS_26573619_Chip-Seq_HEK293_Human2.04781966
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03206534
19P300_19829295_ChIP-Seq_ESCs_Human2.03139519
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.97929915
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.93042027
22* SMAD4_21799915_ChIP-Seq_A2780_Human1.90588380
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84930074
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.82002824
25STAT3_23295773_ChIP-Seq_U87_Human1.80749411
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79153589
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77953086
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77102267
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76345221
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76284945
31TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.70122634
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65209165
33AR_21572438_ChIP-Seq_LNCaP_Human1.60927227
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53305408
35TP53_16413492_ChIP-PET_HCT116_Human1.52829556
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52348028
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52323596
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51941334
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48800894
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.47521438
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.46543233
42TCF4_23295773_ChIP-Seq_U87_Human1.45965635
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45380861
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45358357
45ER_23166858_ChIP-Seq_MCF-7_Human1.40900405
46CBP_20019798_ChIP-Seq_JUKART_Human1.40149604
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40149604
48VDR_22108803_ChIP-Seq_LS180_Human1.39324501
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.39312097
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.37784877
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36104286
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35220405
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35220405
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35073198
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34585496
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33904792
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32831832
58AR_25329375_ChIP-Seq_VCAP_Human1.30448901
59AHR_22903824_ChIP-Seq_MCF-7_Human1.30029595
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29396014
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29396014
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28984488
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28481198
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28004561
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24261025
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.23008682
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.22782060
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21333328
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20824229
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18300875
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.17464689
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.15963536
73BCAT_22108803_ChIP-Seq_LS180_Human1.14947685
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.14845419
75* ELK1_19687146_ChIP-ChIP_HELA_Human1.14177892
76P53_22387025_ChIP-Seq_ESCs_Mouse1.10869229
77RUNX2_22187159_ChIP-Seq_PCA_Human1.10812822
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10747667
79TP53_18474530_ChIP-ChIP_U2OS_Human1.10409707
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09420933
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09318833
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.08536175
83SOX9_26525672_Chip-Seq_HEART_Mouse1.07311372
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.07063790
85GATA1_22025678_ChIP-Seq_K562_Human1.06218208
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05657047
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03438263
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03383547
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01787242
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01601017
91TCF4_22108803_ChIP-Seq_LS180_Human1.01520946
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01169099
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00864111
94BRD4_25478319_ChIP-Seq_HGPS_Human1.00799389
95CDX2_22108803_ChIP-Seq_LS180_Human1.00503267
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.00056386
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99526655
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99462680
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97717528
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95879054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.81653399
2MP0000569_abnormal_digit_pigmentation4.87605961
3MP0002009_preneoplasia3.46789588
4MP0010352_gastrointestinal_tract_polyps2.92792167
5MP0003890_abnormal_embryonic-extraembry2.88706103
6MP0003221_abnormal_cardiomyocyte_apopto2.00674932
7MP0001984_abnormal_olfaction1.89114238
8MP0000383_abnormal_hair_follicle1.86949976
9MP0010678_abnormal_skin_adnexa1.82665831
10MP0001661_extended_life_span1.74297255
11MP0008877_abnormal_DNA_methylation1.72368859
12MP0009697_abnormal_copulation1.70603125
13MP0005187_abnormal_penis_morphology1.68327190
14MP0003937_abnormal_limbs/digits/tail_de1.65105650
15MP0002102_abnormal_ear_morphology1.63624769
16MP0002638_abnormal_pupillary_reflex1.59598882
17MP0010094_abnormal_chromosome_stability1.54214168
18MP0008058_abnormal_DNA_repair1.53163040
19MP0000427_abnormal_hair_cycle1.51192108
20MP0003941_abnormal_skin_development1.49904411
21MP0000778_abnormal_nervous_system1.49842820
22MP0005645_abnormal_hypothalamus_physiol1.46614060
23MP0000537_abnormal_urethra_morphology1.42515492
24MP0005248_abnormal_Harderian_gland1.38810898
25MP0002332_abnormal_exercise_endurance1.35439604
26MP0003077_abnormal_cell_cycle1.32153775
27MP0009046_muscle_twitch1.29735998
28MP0010234_abnormal_vibrissa_follicle1.27863894
29MP0008007_abnormal_cellular_replicative1.26588922
30MP0000516_abnormal_urinary_system1.25563932
31MP0005367_renal/urinary_system_phenotyp1.25563932
32MP0010307_abnormal_tumor_latency1.24764888
33MP0005253_abnormal_eye_physiology1.24063843
34MP0003787_abnormal_imprinting1.23088878
35MP0005275_abnormal_skin_tensile1.17809152
36MP0003646_muscle_fatigue1.17668133
37MP0003880_abnormal_central_pattern1.17097312
38MP0002822_catalepsy1.16719302
39MP0000647_abnormal_sebaceous_gland1.16133835
40MP0002751_abnormal_autonomic_nervous1.15619513
41MP0001299_abnormal_eye_distance/1.14977679
42MP0009703_decreased_birth_body1.14165161
43MP0004270_analgesia1.13864300
44MP0005386_behavior/neurological_phenoty1.11626989
45MP0004924_abnormal_behavior1.11626989
46MP0003121_genomic_imprinting1.10531509
47MP0006276_abnormal_autonomic_nervous1.10493484
48MP0004197_abnormal_fetal_growth/weight/1.07227742
49MP0002233_abnormal_nose_morphology1.06211326
50MP0001177_atelectasis1.05169952
51MP0004145_abnormal_muscle_electrophysio1.03028753
52MP0002084_abnormal_developmental_patter1.01166778
53MP0003935_abnormal_craniofacial_develop0.98885774
54MP0002088_abnormal_embryonic_growth/wei0.97302485
55MP0006072_abnormal_retinal_apoptosis0.95960580
56MP0000015_abnormal_ear_pigmentation0.95367573
57MP0003984_embryonic_growth_retardation0.94559527
58MP0003868_abnormal_feces_composition0.92839992
59MP0000749_muscle_degeneration0.92331187
60MP0003385_abnormal_body_wall0.92071723
61MP0001915_intracranial_hemorrhage0.91656306
62MP0005266_abnormal_metabolism0.91555208
63MP0004233_abnormal_muscle_weight0.89960266
64MP0000631_abnormal_neuroendocrine_gland0.89082852
65MP0001529_abnormal_vocalization0.87569094
66MP0001293_anophthalmia0.87279830
67MP0004084_abnormal_cardiac_muscle0.86321073
68MP0004036_abnormal_muscle_relaxation0.84006484
69MP0000371_diluted_coat_color0.83929261
70MP0000013_abnormal_adipose_tissue0.83007776
71MP0004808_abnormal_hematopoietic_stem0.82943242
72MP0005391_vision/eye_phenotype0.82870844
73MP0001672_abnormal_embryogenesis/_devel0.82819097
74MP0005380_embryogenesis_phenotype0.82819097
75MP0003111_abnormal_nucleus_morphology0.82237837
76MP0002086_abnormal_extraembryonic_tissu0.82134740
77MP0002095_abnormal_skin_pigmentation0.81866589
78MP0002166_altered_tumor_susceptibility0.81280529
79MP0000428_abnormal_craniofacial_morphol0.80560266
80MP0001879_abnormal_lymphatic_vessel0.80075475
81MP0004134_abnormal_chest_morphology0.78161546
82MP0003786_premature_aging0.77356422
83MP0005171_absent_coat_pigmentation0.76663548
84MP0003950_abnormal_plasma_membrane0.75777229
85MP0003718_maternal_effect0.74437393
86MP0002697_abnormal_eye_size0.73901978
87MP0001286_abnormal_eye_development0.73472891
88MP0003755_abnormal_palate_morphology0.73420387
89MP0004484_altered_response_of0.73140074
90MP0004811_abnormal_neuron_physiology0.73111046
91MP0000432_abnormal_head_morphology0.71330503
92MP0004215_abnormal_myocardial_fiber0.71088824
93MP0001486_abnormal_startle_reflex0.71021335
94MP0005647_abnormal_sex_gland0.70223201
95MP0003861_abnormal_nervous_system0.69529429
96MP0002168_other_aberrant_phenotype0.68653530
97MP0005395_other_phenotype0.66578452
98MP0003119_abnormal_digestive_system0.65762371
99MP0005551_abnormal_eye_electrophysiolog0.65740673
100MP0008770_decreased_survivor_rate0.65438572

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.03862387
2Hyperventilation (HP:0002883)3.59661759
3Volvulus (HP:0002580)3.49164934
4Chronic hepatic failure (HP:0100626)2.99284420
5Astrocytoma (HP:0009592)2.90996010
6Abnormality of the astrocytes (HP:0100707)2.90996010
7Fair hair (HP:0002286)2.85261847
8Aplasia/Hypoplasia of the tibia (HP:0005772)2.73271899
9Drooling (HP:0002307)2.71613987
10Thyroid carcinoma (HP:0002890)2.68089825
11Hepatoblastoma (HP:0002884)2.66844650
12Tubulointerstitial nephritis (HP:0001970)2.65732347
13Medulloblastoma (HP:0002885)2.53742535
14Curly hair (HP:0002212)2.46096290
15Colon cancer (HP:0003003)2.45354112
16Protruding tongue (HP:0010808)2.44503164
17Glioma (HP:0009733)2.42960132
18Excessive salivation (HP:0003781)2.42288746
19Broad-based gait (HP:0002136)2.38153830
20Gaze-evoked nystagmus (HP:0000640)2.37719317
21Long clavicles (HP:0000890)2.34731705
22Truncal obesity (HP:0001956)2.33011029
23Short tibia (HP:0005736)2.31328807
24Abnormality of chromosome stability (HP:0003220)2.24012619
25Widely spaced teeth (HP:0000687)2.20124192
26Tented upper lip vermilion (HP:0010804)2.18424463
27Genital tract atresia (HP:0001827)2.17071263
28Poor coordination (HP:0002370)2.15170692
29Heterotopia (HP:0002282)2.14604378
30Rhabdomyosarcoma (HP:0002859)2.13687590
31Generalized hypopigmentation of hair (HP:0011358)2.08904038
32Hypoplastic labia majora (HP:0000059)2.08587160
33Congenital primary aphakia (HP:0007707)2.08551998
34Absent speech (HP:0001344)2.08327195
35Progressive inability to walk (HP:0002505)2.07184009
36Submucous cleft hard palate (HP:0000176)2.06539290
37Subacute progressive viral hepatitis (HP:0006572)2.05621238
38Gait imbalance (HP:0002141)2.04103667
39Short chin (HP:0000331)2.02069869
40Pancreatic cysts (HP:0001737)2.00272594
41Acute myeloid leukemia (HP:0004808)1.99398272
42Abnormality of the labia majora (HP:0012881)1.99122945
43Vaginal atresia (HP:0000148)1.98664440
44Hypoplastic iliac wings (HP:0002866)1.98150004
45Febrile seizures (HP:0002373)1.98019906
46Ependymoma (HP:0002888)1.97648821
47Sandal gap (HP:0001852)1.97193365
48Medial flaring of the eyebrow (HP:0010747)1.96401955
49Hip dysplasia (HP:0001385)1.95923098
50Blue irides (HP:0000635)1.94609186
51Cystic hygroma (HP:0000476)1.93667772
52Nephrogenic diabetes insipidus (HP:0009806)1.93452958
53Cupped ear (HP:0000378)1.92894793
54Bifid tongue (HP:0010297)1.92452122
55Short 4th metacarpal (HP:0010044)1.91446526
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91446526
57Genetic anticipation (HP:0003743)1.89033493
58Thyroiditis (HP:0100646)1.88781102
59Intestinal atresia (HP:0011100)1.88690686
60Decreased lacrimation (HP:0000633)1.88602505
61Cortical dysplasia (HP:0002539)1.88163897
62Large earlobe (HP:0009748)1.88130219
63Fibular hypoplasia (HP:0003038)1.87715925
64Neoplasm of the oral cavity (HP:0100649)1.85851400
65Prominent nose (HP:0000448)1.84109433
66Narrow palate (HP:0000189)1.82933803
67Abnormality of the epiphyses of the hand (HP:0005924)1.82792564
68Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.82378005
69Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.82332038
70Aplasia/Hypoplasia of the fibula (HP:0006492)1.80675959
71Ectropion (HP:0000656)1.79680811
72Urinary urgency (HP:0000012)1.78971093
73Abnormality of the renal cortex (HP:0011035)1.77674359
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.77346795
75Downturned corners of mouth (HP:0002714)1.75265797
76Chromsome breakage (HP:0040012)1.75089821
77Neoplasm of the adrenal cortex (HP:0100641)1.73729790
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.73391425
79Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71296239
80Neoplasm of striated muscle (HP:0009728)1.70908791
81Scanning speech (HP:0002168)1.70565792
82Cerebellar dysplasia (HP:0007033)1.69482070
83Renal cortical cysts (HP:0000803)1.69320691
84Pancreatic fibrosis (HP:0100732)1.68110053
85Lissencephaly (HP:0001339)1.68041344
86Abnormality of the hip-girdle musculature (HP:0001445)1.65990038
87Abnormality of the musculature of the pelvis (HP:0001469)1.65990038
88Pheochromocytoma (HP:0002666)1.64732846
89Abnormality of the renal medulla (HP:0100957)1.64148714
90Embryonal renal neoplasm (HP:0011794)1.63999476
91Nephroblastoma (Wilms tumor) (HP:0002667)1.63786260
92Cutaneous finger syndactyly (HP:0010554)1.62880645
93Oligodactyly (hands) (HP:0001180)1.62870049
94Exotropia (HP:0000577)1.62561334
95Labial hypoplasia (HP:0000066)1.61373563
96Gastroesophageal reflux (HP:0002020)1.60382175
97Abnormal auditory evoked potentials (HP:0006958)1.60312949
98Broad ribs (HP:0000885)1.60274310
99Abnormal pancreas size (HP:0012094)1.59985321
100Abnormality of the labia minora (HP:0012880)1.59759431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.65857961
2MAP3K43.43319895
3CASK3.38395364
4AKT33.09549234
5ZAK2.36958970
6EIF2AK32.25817932
7BRD42.17908033
8BCR2.13516708
9EPHA32.12499937
10MAP2K72.11784585
11TRIM281.85154207
12SRPK11.84141650
13LATS11.83464080
14BMPR1B1.82597514
15ERBB31.78229718
16WNK31.73337588
17SGK21.70784315
18CAMK1D1.69987592
19ACVR1B1.66749120
20MKNK21.65194154
21CAMK1G1.61089165
22CSNK1A1L1.59660650
23OBSCN1.58547803
24MAP4K21.51878077
25MARK11.50135832
26MAPK131.46345965
27NEK91.42784985
28STK38L1.42141374
29CSNK1G11.33930485
30NUAK11.33178773
31BRSK21.20766575
32NLK1.13396097
33FER1.11450651
34SGK4941.07467357
35SGK2231.07467357
36STK391.06162834
37VRK11.02079633
38CSNK1G21.02048958
39FLT31.01961248
40CSNK1G31.01124104
41SGK31.00022577
42TNIK0.96404773
43NTRK30.95824842
44DYRK30.94731479
45PDK20.90941841
46PKN20.89695267
47CDK60.88610095
48MAP2K40.88591487
49RPS6KA40.86804427
50CCNB10.85599469
51RPS6KA50.81807056
52PAK30.80479760
53CAMKK20.80027364
54ATM0.79461412
55CAMK40.78927266
56NEK60.77039101
57CDK120.73893027
58TSSK60.73409054
59TLK10.72677657
60MKNK10.70999674
61PBK0.67507698
62PINK10.66727761
63STK30.66116426
64ATR0.65773565
65PRKAA10.63674655
66PKN10.63409004
67MAP3K20.62714907
68MET0.62042177
69PRKCE0.61654777
70MELK0.61388168
71TEC0.61234993
72PIK3CA0.59735874
73CDK30.58388776
74FGFR10.55454918
75EPHA40.52112244
76PRKAA20.49636316
77IRAK10.49281375
78CHEK10.49181396
79NTRK20.48570554
80KSR10.47482562
81SCYL20.46670941
82DYRK1A0.46595993
83RAF10.46060897
84PLK40.45530584
85OXSR10.44509276
86WEE10.41359262
87EGFR0.41201989
88WNK10.40114505
89YES10.39307696
90SGK10.39256307
91MST40.39110258
92PDGFRB0.37851935
93ERBB40.37431853
94PLK20.36757216
95PLK30.36755712
96AURKB0.36350066
97PLK10.36089192
98CSNK1D0.35754036
99RPS6KB10.35644360
100PIK3CG0.35186192

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.88311429
2Alcoholism_Homo sapiens_hsa050343.35723414
3Non-homologous end-joining_Homo sapiens_hsa034502.46099626
4Circadian rhythm_Homo sapiens_hsa047102.26977667
5Fanconi anemia pathway_Homo sapiens_hsa034602.16205412
6Lysine degradation_Homo sapiens_hsa003101.89142917
7TGF-beta signaling pathway_Homo sapiens_hsa043501.73296887
8Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.73109146
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69271726
10Steroid biosynthesis_Homo sapiens_hsa001001.68222038
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60805368
12Propanoate metabolism_Homo sapiens_hsa006401.56256206
13Type II diabetes mellitus_Homo sapiens_hsa049301.50725078
14Adherens junction_Homo sapiens_hsa045201.48927589
15Nicotine addiction_Homo sapiens_hsa050331.42577405
16Colorectal cancer_Homo sapiens_hsa052101.41738047
17Taste transduction_Homo sapiens_hsa047421.40071483
18Basal transcription factors_Homo sapiens_hsa030221.39578496
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37805123
20RNA degradation_Homo sapiens_hsa030181.36410960
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34113076
22Viral carcinogenesis_Homo sapiens_hsa052031.33350261
23FoxO signaling pathway_Homo sapiens_hsa040681.31486480
24Dorso-ventral axis formation_Homo sapiens_hsa043201.30494515
25MicroRNAs in cancer_Homo sapiens_hsa052061.28383739
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27654334
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26215033
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24171468
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23134729
30Inositol phosphate metabolism_Homo sapiens_hsa005621.21844571
31p53 signaling pathway_Homo sapiens_hsa041151.12342848
32Selenocompound metabolism_Homo sapiens_hsa004501.08787835
33RNA transport_Homo sapiens_hsa030131.08155019
34Cell cycle_Homo sapiens_hsa041101.07166683
35Vitamin B6 metabolism_Homo sapiens_hsa007501.04204391
36mRNA surveillance pathway_Homo sapiens_hsa030151.03717791
37Prolactin signaling pathway_Homo sapiens_hsa049171.03447669
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00160881
39Hippo signaling pathway_Homo sapiens_hsa043901.00071977
40Butanoate metabolism_Homo sapiens_hsa006500.97315474
41Fatty acid biosynthesis_Homo sapiens_hsa000610.96615661
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95494287
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95420716
44Prostate cancer_Homo sapiens_hsa052150.94580387
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93788981
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92992025
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92639540
48Endometrial cancer_Homo sapiens_hsa052130.89393198
49ABC transporters_Homo sapiens_hsa020100.88515532
50Glioma_Homo sapiens_hsa052140.86268257
51Oocyte meiosis_Homo sapiens_hsa041140.85077899
52ErbB signaling pathway_Homo sapiens_hsa040120.83153367
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82944215
54Long-term depression_Homo sapiens_hsa047300.81956525
55AMPK signaling pathway_Homo sapiens_hsa041520.78630592
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78331222
57mTOR signaling pathway_Homo sapiens_hsa041500.77398825
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74900466
59Dopaminergic synapse_Homo sapiens_hsa047280.73218392
60Axon guidance_Homo sapiens_hsa043600.71227193
61Homologous recombination_Homo sapiens_hsa034400.68162960
62Glutamatergic synapse_Homo sapiens_hsa047240.67647501
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66265326
64Small cell lung cancer_Homo sapiens_hsa052220.66207995
65Regulation of autophagy_Homo sapiens_hsa041400.65985506
66Tight junction_Homo sapiens_hsa045300.65614674
67Melanoma_Homo sapiens_hsa052180.63738742
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.62456679
69GABAergic synapse_Homo sapiens_hsa047270.60956245
70Sulfur metabolism_Homo sapiens_hsa009200.60870441
71Choline metabolism in cancer_Homo sapiens_hsa052310.60492803
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60020327
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59486322
74Wnt signaling pathway_Homo sapiens_hsa043100.58785777
75Insulin resistance_Homo sapiens_hsa049310.57896356
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57511407
77Protein export_Homo sapiens_hsa030600.57034923
78Circadian entrainment_Homo sapiens_hsa047130.56772018
79Ether lipid metabolism_Homo sapiens_hsa005650.53496203
80Renin secretion_Homo sapiens_hsa049240.53226160
81Hedgehog signaling pathway_Homo sapiens_hsa043400.52992400
82Phototransduction_Homo sapiens_hsa047440.51902144
83Glucagon signaling pathway_Homo sapiens_hsa049220.50933165
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50857659
85Insulin signaling pathway_Homo sapiens_hsa049100.48535026
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47152522
87RNA polymerase_Homo sapiens_hsa030200.46935893
88Morphine addiction_Homo sapiens_hsa050320.45150988
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44926647
90cAMP signaling pathway_Homo sapiens_hsa040240.42933087
91Renal cell carcinoma_Homo sapiens_hsa052110.42906384
92Cholinergic synapse_Homo sapiens_hsa047250.42790686
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42233767
94Pancreatic cancer_Homo sapiens_hsa052120.41540184
95Amphetamine addiction_Homo sapiens_hsa050310.39701130
96Focal adhesion_Homo sapiens_hsa045100.39082760
97Sphingolipid metabolism_Homo sapiens_hsa006000.37716001
98Calcium signaling pathway_Homo sapiens_hsa040200.37477687
99Proteoglycans in cancer_Homo sapiens_hsa052050.36840755
100Ovarian steroidogenesis_Homo sapiens_hsa049130.36571989

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