ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.08953929
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.06985948
3	response to pheromone (GO:0019236)	4.04148112
4	neural tube formation (GO:0001841)	4.00591826
5	piRNA metabolic process (GO:0034587)	3.97729622
6	nonmotile primary cilium assembly (GO:0035058)	3.66077430
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.55724808
8	platelet dense granule organization (GO:0060155)	3.46157512
9	centriole replication (GO:0007099)	3.35921499
10	nucleobase catabolic process (GO:0046113)	3.34803505
11	axoneme assembly (GO:0035082)	3.34602772
12	epithelial cilium movement (GO:0003351)	3.33780455
13	fucose catabolic process (GO:0019317)	3.31538250
14	L-fucose metabolic process (GO:0042354)	3.31538250
15	L-fucose catabolic process (GO:0042355)	3.31538250
16	somite rostral/caudal axis specification (GO:0032525)	3.29455551
17	synapsis (GO:0007129)	3.27870565
18	regulation of cilium movement (GO:0003352)	3.25075297
19	reciprocal DNA recombination (GO:0035825)	3.21430478
20	reciprocal meiotic recombination (GO:0007131)	3.21430478
21	protein K6-linked ubiquitination (GO:0085020)	3.16120184
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13844379
23	NADH dehydrogenase complex assembly (GO:0010257)	3.13844379
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13844379
25	regulation of meiosis I (GO:0060631)	3.11854301
26	cornea development in camera-type eye (GO:0061303)	3.10102091
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.08379992
28	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.07171829
29	protein K11-linked deubiquitination (GO:0035871)	3.07099271
30	DNA deamination (GO:0045006)	3.05839699
31	ketone body metabolic process (GO:1902224)	3.03885391
32	intraciliary transport (GO:0042073)	3.03309197
33	DNA methylation involved in gamete generation (GO:0043046)	3.02741618
34	limb bud formation (GO:0060174)	3.01208332
35	cilium movement (GO:0003341)	2.99899169
36	respiratory chain complex IV assembly (GO:0008535)	2.99034148
37	DNA double-strand break processing (GO:0000729)	2.98114015
38	negative regulation of telomere maintenance (GO:0032205)	2.96035878
39	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.91887234
40	replication fork processing (GO:0031297)	2.86619725
41	indolalkylamine metabolic process (GO:0006586)	2.86379034
42	protein complex biogenesis (GO:0070271)	2.84783690
43	cellular ketone body metabolic process (GO:0046950)	2.84240688
44	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.83741064
45	cilium morphogenesis (GO:0060271)	2.82936944
46	inositol phosphate catabolic process (GO:0071545)	2.82795020
47	regulation of hexokinase activity (GO:1903299)	2.81301642
48	regulation of glucokinase activity (GO:0033131)	2.81301642
49	gamma-aminobutyric acid transport (GO:0015812)	2.81190006
50	spinal cord association neuron differentiation (GO:0021527)	2.77634861
51	protein localization to cilium (GO:0061512)	2.74477152
52	protein-cofactor linkage (GO:0018065)	2.74377800
53	behavioral response to ethanol (GO:0048149)	2.73652166
54	synaptic transmission, cholinergic (GO:0007271)	2.72788951
55	postsynaptic membrane organization (GO:0001941)	2.72328088
56	presynaptic membrane assembly (GO:0097105)	2.71997048
57	left/right axis specification (GO:0070986)	2.70960757
58	protein neddylation (GO:0045116)	2.69125555
59	photoreceptor cell development (GO:0042461)	2.68664446
60	microtubule anchoring (GO:0034453)	2.65600238
61	detection of light stimulus involved in visual perception (GO:0050908)	2.65325281
62	detection of light stimulus involved in sensory perception (GO:0050962)	2.65325281
63	male meiosis (GO:0007140)	2.64907483
64	regulation of timing of cell differentiation (GO:0048505)	2.63915920
65	cilium or flagellum-dependent cell motility (GO:0001539)	2.63071635
66	forebrain neuron differentiation (GO:0021879)	2.61904521
67	mitochondrial respiratory chain complex assembly (GO:0033108)	2.61683250
68	cell differentiation in spinal cord (GO:0021515)	2.60571892
69	sympathetic nervous system development (GO:0048485)	2.60349647
70	anterograde synaptic vesicle transport (GO:0048490)	2.59373910
71	transmission of nerve impulse (GO:0019226)	2.58819968
72	resolution of meiotic recombination intermediates (GO:0000712)	2.58544491
73	recombinational repair (GO:0000725)	2.55860620
74	sperm motility (GO:0030317)	2.55525335
75	regulation of telomere maintenance (GO:0032204)	2.54113642
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.52956804
77	double-strand break repair via homologous recombination (GO:0000724)	2.52719569
78	cilium organization (GO:0044782)	2.52458696
79	cytochrome complex assembly (GO:0017004)	2.52267760
80	male meiosis I (GO:0007141)	2.52127067
81	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.51791468
82	regulation of translation, ncRNA-mediated (GO:0045974)	2.51791468
83	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.51791468
84	protein polyglutamylation (GO:0018095)	2.50646257
85	reflex (GO:0060004)	2.50000565
86	meiotic cell cycle (GO:0051321)	2.49899223
87	embryonic epithelial tube formation (GO:0001838)	2.49876374
88	eye photoreceptor cell development (GO:0042462)	2.47078721
89	kidney morphogenesis (GO:0060993)	2.46967979
90	retinal cone cell development (GO:0046549)	2.46500075
91	photoreceptor cell maintenance (GO:0045494)	2.46168683
92	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.45715246
93	multicellular organism reproduction (GO:0032504)	2.45378309
94	regulation of development, heterochronic (GO:0040034)	2.45249309
95	cilium assembly (GO:0042384)	2.44776779
96	meiotic chromosome segregation (GO:0045132)	2.43737893
97	adaptation of signaling pathway (GO:0023058)	2.43182757
98	retinal rod cell development (GO:0046548)	2.42429090
99	inositol phosphate dephosphorylation (GO:0046855)	2.42413854
100	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.42413854

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.13396341
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.00677597
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.93494326
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.71982359
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.68673542
6	VDR_22108803_ChIP-Seq_LS180_Human	2.63518546
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51001379
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50936641
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33065678
10	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.31479667
11	FUS_26573619_Chip-Seq_HEK293_Human	2.27185430
12	EWS_26573619_Chip-Seq_HEK293_Human	2.24947549
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23730938
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.15192202
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.12686132
16	P300_19829295_ChIP-Seq_ESCs_Human	2.08787933
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.01248655
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99657022
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92569338
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.91392581
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.88082384
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86503179
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.83787700
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82189957
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.75793399
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71738976
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.70018926
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.70018926
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65696001
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65337171
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64379098
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.63129509
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62907269
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59729107
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55661693
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54672623
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.54057688
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52990342
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50144192
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49615751
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45865609
42	STAT3_23295773_ChIP-Seq_U87_Human	1.44439988
43	AR_25329375_ChIP-Seq_VCAP_Human	1.44195459
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44105149
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44105149
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43243774
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41676659
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40696498
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38334780
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37021162
51	TCF4_23295773_ChIP-Seq_U87_Human	1.36857466
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.35915553
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34524640
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33383062
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33157437
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32212337
57	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.31646553
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28874766
59	* VDR_23849224_ChIP-Seq_CD4+_Human	1.28669121
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27716384
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27716384
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.27617739
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26226441
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25281336
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24782302
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23225869
67	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23206602
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20028620
69	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18288250
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17461004
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16252453
72	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.16206006
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15951716
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15393808
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12194989
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.10913454
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10755969
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10442404
79	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09326375
80	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.08872139
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07649354
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06016525
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05157332
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04960284
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04960284
86	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.04677331
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02640772
88	NCOR_22424771_ChIP-Seq_293T_Human	1.02569536
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02072679
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01958904
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00417929
92	AR_20517297_ChIP-Seq_VCAP_Human	0.99502783
93	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.99371839
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98817064
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98600066
96	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97692962
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97070724
98	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96013967
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95287560
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95143102

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.51130098
2	MP0000569_abnormal_digit_pigmentation	3.05396696
3	MP0003787_abnormal_imprinting	2.75836766
4	MP0002102_abnormal_ear_morphology	2.73014345
5	MP0006292_abnormal_olfactory_placode	2.56560056
6	MP0000372_irregular_coat_pigmentation	2.38061771
7	MP0005645_abnormal_hypothalamus_physiol	2.26094308
8	MP0006072_abnormal_retinal_apoptosis	2.19871343
9	MP0003646_muscle_fatigue	2.18183755
10	MP0005551_abnormal_eye_electrophysiolog	2.15723374
11	MP0003136_yellow_coat_color	2.12762822
12	MP0008995_early_reproductive_senescence	2.00374461
13	MP0004142_abnormal_muscle_tone	1.96647785
14	MP0004043_abnormal_pH_regulation	1.92526143
15	MP0000631_abnormal_neuroendocrine_gland	1.92415319
16	MP0002163_abnormal_gland_morphology	1.87721906
17	MP0003195_calcinosis	1.85897336
18	MP0005253_abnormal_eye_physiology	1.84914312
19	MP0001529_abnormal_vocalization	1.81776991
20	MP0005171_absent_coat_pigmentation	1.79670156
21	MP0001984_abnormal_olfaction	1.78141132
22	MP0008789_abnormal_olfactory_epithelium	1.78053550
23	MP0005646_abnormal_pituitary_gland	1.77617647
24	MP0002638_abnormal_pupillary_reflex	1.76628335
25	MP0004133_heterotaxia	1.73448131
26	MP0002234_abnormal_pharynx_morphology	1.73087101
27	MP0003121_genomic_imprinting	1.71161371
28	MP0002653_abnormal_ependyma_morphology	1.67875337
29	MP0009745_abnormal_behavioral_response	1.61859302
30	MP0008058_abnormal_DNA_repair	1.60873665
31	MP0009046_muscle_twitch	1.60125444
32	MP0002837_dystrophic_cardiac_calcinosis	1.57764309
33	MP0003880_abnormal_central_pattern	1.57744713
34	MP0005394_taste/olfaction_phenotype	1.55564560
35	MP0005499_abnormal_olfactory_system	1.55564560
36	MP0006276_abnormal_autonomic_nervous	1.54292954
37	MP0008872_abnormal_physiological_respon	1.52848075
38	MP0001968_abnormal_touch/_nociception	1.51001478
39	MP0002272_abnormal_nervous_system	1.48659280
40	MP0005379_endocrine/exocrine_gland_phen	1.45927911
41	MP0002095_abnormal_skin_pigmentation	1.44991266
42	MP0005174_abnormal_tail_pigmentation	1.44643308
43	MP0002938_white_spotting	1.43519240
44	MP0003718_maternal_effect	1.40524769
45	MP0000778_abnormal_nervous_system	1.34217375
46	MP0001986_abnormal_taste_sensitivity	1.32509639
47	MP0004885_abnormal_endolymph	1.31498587
48	MP0002876_abnormal_thyroid_physiology	1.30859954
49	MP0003122_maternal_imprinting	1.29184722
50	MP0001486_abnormal_startle_reflex	1.27397477
51	MP0000427_abnormal_hair_cycle	1.27374982
52	MP0002822_catalepsy	1.26891156
53	MP0002735_abnormal_chemical_nociception	1.25251842
54	MP0005075_abnormal_melanosome_morpholog	1.24968810
55	MP0005386_behavior/neurological_phenoty	1.21457732
56	MP0004924_abnormal_behavior	1.21457732
57	MP0008875_abnormal_xenobiotic_pharmacok	1.19795655
58	MP0004742_abnormal_vestibular_system	1.19693309
59	MP0001293_anophthalmia	1.18312484
60	MP0002160_abnormal_reproductive_system	1.17449679
61	MP0003890_abnormal_embryonic-extraembry	1.16179789
62	MP0002736_abnormal_nociception_after	1.15683522
63	MP0001324_abnormal_eye_pigmentation	1.15616646
64	MP0002928_abnormal_bile_duct	1.15083510
65	MP0002572_abnormal_emotion/affect_behav	1.14059379
66	MP0005389_reproductive_system_phenotype	1.13826656
67	MP0003786_premature_aging	1.12688236
68	MP0002751_abnormal_autonomic_nervous	1.12636873
69	MP0001485_abnormal_pinna_reflex	1.11140940
70	MP0002064_seizures	1.09716807
71	MP0002210_abnormal_sex_determination	1.07433027
72	MP0005195_abnormal_posterior_eye	1.05987953
73	MP0001919_abnormal_reproductive_system	1.03872172
74	MP0003635_abnormal_synaptic_transmissio	1.03640578
75	MP0002557_abnormal_social/conspecific_i	1.02735019
76	MP0002067_abnormal_sensory_capabilities	1.02086589
77	MP0008961_abnormal_basal_metabolism	1.01255999
78	MP0003698_abnormal_male_reproductive	0.99817342
79	MP0001929_abnormal_gametogenesis	0.99596780
80	MP0001502_abnormal_circadian_rhythm	0.96660452
81	MP0000015_abnormal_ear_pigmentation	0.95100084
82	MP0002752_abnormal_somatic_nervous	0.92764852
83	MP0002063_abnormal_learning/memory/cond	0.92607433
84	MP0005084_abnormal_gallbladder_morpholo	0.91297426
85	MP0000026_abnormal_inner_ear	0.88913070
86	MP0000653_abnormal_sex_gland	0.88770957
87	MP0001501_abnormal_sleep_pattern	0.88660289
88	MP0003252_abnormal_bile_duct	0.86215338
89	MP0002277_abnormal_respiratory_mucosa	0.86070855
90	MP0001970_abnormal_pain_threshold	0.85483734
91	MP0005391_vision/eye_phenotype	0.84610295
92	MP0003119_abnormal_digestive_system	0.83700277
93	MP0005647_abnormal_sex_gland	0.83128808
94	MP0001145_abnormal_male_reproductive	0.82711860
95	MP0004147_increased_porphyrin_level	0.82038002
96	MP0001905_abnormal_dopamine_level	0.80733379
97	MP0002733_abnormal_thermal_nociception	0.78864862
98	MP0003011_delayed_dark_adaptation	0.78610270
99	MP0004145_abnormal_muscle_electrophysio	0.78341424
100	MP0004859_abnormal_synaptic_plasticity	0.75527014

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	3.76091372
2	Congenital stationary night blindness (HP:0007642)	3.69897128
3	Pancreatic cysts (HP:0001737)	3.66454783
4	Abnormality of midbrain morphology (HP:0002418)	3.56012300
5	Molar tooth sign on MRI (HP:0002419)	3.56012300
6	Pancreatic fibrosis (HP:0100732)	3.42380826
7	True hermaphroditism (HP:0010459)	3.35906727
8	Nephronophthisis (HP:0000090)	3.30333201
9	Medial flaring of the eyebrow (HP:0010747)	2.99088598
10	Thyroid-stimulating hormone excess (HP:0002925)	2.97493079
11	Hyperventilation (HP:0002883)	2.92514889
12	Abnormality of the renal medulla (HP:0100957)	2.90851410
13	Cerebellar dysplasia (HP:0007033)	2.86907167
14	Abnormality of the renal cortex (HP:0011035)	2.79984139
15	Pendular nystagmus (HP:0012043)	2.76366097
16	Abnormality of the labia minora (HP:0012880)	2.57315682
17	Lissencephaly (HP:0001339)	2.53571888
18	Chronic hepatic failure (HP:0100626)	2.50655841
19	Septo-optic dysplasia (HP:0100842)	2.47624346
20	Optic nerve hypoplasia (HP:0000609)	2.46881586
21	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.45916447
22	Hypoplasia of the fovea (HP:0007750)	2.45916447
23	Abolished electroretinogram (ERG) (HP:0000550)	2.42733295
24	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.39893443
25	Gait imbalance (HP:0002141)	2.38425687
26	Acute necrotizing encephalopathy (HP:0006965)	2.35303928
27	Renal cortical cysts (HP:0000803)	2.33537999
28	Polyuria (HP:0000103)	2.31559857
29	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.30699883
30	Nephrogenic diabetes insipidus (HP:0009806)	2.29866101
31	Attenuation of retinal blood vessels (HP:0007843)	2.28738926
32	Congenital primary aphakia (HP:0007707)	2.27953441
33	Mitochondrial inheritance (HP:0001427)	2.23700186
34	Intestinal atresia (HP:0011100)	2.22972287
35	Abnormality of the fovea (HP:0000493)	2.21736880
36	Increased CSF lactate (HP:0002490)	2.20455868
37	Inability to walk (HP:0002540)	2.17959208
38	Broad-based gait (HP:0002136)	2.17862457
39	Methylmalonic acidemia (HP:0002912)	2.14988366
40	Abnormality of alanine metabolism (HP:0010916)	2.13183117
41	Hyperalaninemia (HP:0003348)	2.13183117
42	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13183117
43	Gaze-evoked nystagmus (HP:0000640)	2.12737862
44	Focal motor seizures (HP:0011153)	2.12615387
45	Progressive macrocephaly (HP:0004481)	2.12021892
46	Febrile seizures (HP:0002373)	2.11990780
47	Metabolic alkalosis (HP:0200114)	2.11300289
48	Genital tract atresia (HP:0001827)	2.08978017
49	Acute encephalopathy (HP:0006846)	2.08354433
50	Neonatal respiratory distress (HP:0002643)	2.06834150
51	Progressive inability to walk (HP:0002505)	2.06821724
52	Cystic liver disease (HP:0006706)	2.02824322
53	Hypoplasia of the pons (HP:0012110)	2.02733112
54	Vaginal atresia (HP:0000148)	2.02676554
55	Abnormality of the pons (HP:0007361)	2.01550511
56	Bile duct proliferation (HP:0001408)	1.99368707
57	Abnormal biliary tract physiology (HP:0012439)	1.99368707
58	Abnormality of the ileum (HP:0001549)	1.99280857
59	Lipid accumulation in hepatocytes (HP:0006561)	1.97414627
60	Anterior segment dysgenesis (HP:0007700)	1.96690524
61	Meckel diverticulum (HP:0002245)	1.95926585
62	Abnormal rod and cone electroretinograms (HP:0008323)	1.94999992
63	Pachygyria (HP:0001302)	1.94689213
64	Anencephaly (HP:0002323)	1.94650462
65	Progressive cerebellar ataxia (HP:0002073)	1.93370360
66	Hepatocellular necrosis (HP:0001404)	1.91463139
67	Decreased central vision (HP:0007663)	1.91216015
68	Oligodactyly (hands) (HP:0001180)	1.90022133
69	Methylmalonic aciduria (HP:0012120)	1.89661519
70	Astigmatism (HP:0000483)	1.89284241
71	Retinal dysplasia (HP:0007973)	1.88525797
72	3-Methylglutaconic aciduria (HP:0003535)	1.88419115
73	Abnormal ciliary motility (HP:0012262)	1.88206768
74	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.87930902
75	Hepatic necrosis (HP:0002605)	1.86125675
76	Postaxial hand polydactyly (HP:0001162)	1.85344035
77	Tubular atrophy (HP:0000092)	1.84962770
78	Hypothermia (HP:0002045)	1.84923675
79	Large for gestational age (HP:0001520)	1.84497357
80	Fair hair (HP:0002286)	1.84264115
81	Increased hepatocellular lipid droplets (HP:0006565)	1.83191959
82	Abnormality of chromosome stability (HP:0003220)	1.82901849
83	Postaxial foot polydactyly (HP:0001830)	1.82486769
84	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82371725
85	Abnormal drinking behavior (HP:0030082)	1.81948867
86	Polydipsia (HP:0001959)	1.81948867
87	Sclerocornea (HP:0000647)	1.81088936
88	Congenital hepatic fibrosis (HP:0002612)	1.80744894
89	Supernumerary spleens (HP:0009799)	1.80410417
90	Hypokalemic alkalosis (HP:0001949)	1.79910874
91	Abnormal mitochondria in muscle tissue (HP:0008316)	1.79149006
92	Abnormal urine output (HP:0012590)	1.76970076
93	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.75528074
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.75380980
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.75380980
96	Dandy-Walker malformation (HP:0001305)	1.75172771
97	Increased circulating renin level (HP:0000848)	1.74641120
98	Optic disc pallor (HP:0000543)	1.72885774
99	Sloping forehead (HP:0000340)	1.71236757
100	Bony spicule pigmentary retinopathy (HP:0007737)	1.70103789

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.00430640
2	NUAK1	3.51041716
3	WNK3	2.99298650
4	BMPR1B	2.64297443
5	TLK1	2.44120851
6	TRIM28	2.27028025
7	LATS1	2.21328157
8	MAP3K4	2.19174084
9	ADRBK2	2.13417001
10	PINK1	2.07764654
11	CAMKK2	1.85758158
12	CASK	1.85325952
13	ZAK	1.76366842
14	WNK4	1.73963661
15	MAP4K2	1.73368048
16	GRK1	1.71255655
17	MARK1	1.66016944
18	TNIK	1.61608002
19	MAPK13	1.57789794
20	TAOK3	1.54766238
21	CDK19	1.45628670
22	NEK1	1.40588058
23	BCR	1.37936801
24	PNCK	1.36666231
25	DYRK2	1.36238976
26	PAK3	1.33461558
27	PIK3CA	1.30315644
28	OXSR1	1.27728243
29	NEK2	1.25145107
30	PLK4	1.24814999
31	TXK	1.24444100
32	MAP2K7	1.19920883
33	ERBB3	1.19692912
34	MKNK2	1.18689052
35	CAMK1D	1.16542208
36	INSRR	1.12997104
37	STK3	1.12576572
38	PLK2	1.12552720
39	CAMK1G	1.05711503
40	PRKCG	1.00472972
41	EIF2AK3	0.98839998
42	VRK1	0.98776612
43	BRSK2	0.97625828
44	CSNK1G2	0.95924978
45	NTRK2	0.95647676
46	MKNK1	0.88479068
47	CDK3	0.88328636
48	CSNK1G1	0.88070140
49	CSNK1G3	0.86879238
50	WEE1	0.82035744
51	SIK2	0.80565183
52	PDK2	0.78492035
53	CAMK1	0.76081418
54	STK38L	0.75673363
55	ADRBK1	0.74868722
56	MARK3	0.74535084
57	IRAK1	0.73712998
58	FGFR2	0.73576323
59	STK39	0.73562095
60	STK11	0.72463470
61	ACVR1B	0.71722442
62	PLK3	0.71689458
63	SRPK1	0.70712957
64	DAPK2	0.70688944
65	NTRK3	0.69768682
66	MAPK15	0.69648557
67	DYRK1A	0.68450935
68	AKT3	0.67385277
69	CSNK1A1L	0.66908340
70	TAF1	0.65569752
71	PKN1	0.64586484
72	PRKCE	0.63614238
73	PRKCI	0.63432681
74	SIK3	0.61045136
75	BRD4	0.60731935
76	BCKDK	0.60584485
77	EPHA4	0.56976665
78	PASK	0.56627551
79	CAMK2A	0.56157046
80	GRK7	0.55693207
81	CSNK1D	0.54359904
82	ATM	0.50033339
83	MUSK	0.49489132
84	RPS6KA5	0.48875322
85	PLK1	0.47996525
86	CCNB1	0.47434205
87	MST4	0.47389924
88	MAP2K6	0.46575748
89	MAPKAPK5	0.46574227
90	CSNK1A1	0.43420125
91	MINK1	0.42616647
92	PRKG1	0.42553398
93	PRKACA	0.42447134
94	TGFBR1	0.42096612
95	TIE1	0.40111884
96	VRK2	0.39033540
97	IKBKB	0.38916662
98	ATR	0.38661718
99	DYRK3	0.38535321
100	PRKAA1	0.38371873

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.84306676
2	Basal transcription factors_Homo sapiens_hsa03022	2.82777524
3	Protein export_Homo sapiens_hsa03060	2.71751284
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.65454342
5	Phototransduction_Homo sapiens_hsa04744	2.59796926
6	Nicotine addiction_Homo sapiens_hsa05033	2.31248144
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29546460
8	Caffeine metabolism_Homo sapiens_hsa00232	2.29271951
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.27342104
10	Parkinsons disease_Homo sapiens_hsa05012	2.18005838
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.17916847
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16017196
13	Butanoate metabolism_Homo sapiens_hsa00650	1.98446828
14	Homologous recombination_Homo sapiens_hsa03440	1.96221608
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.91542467
16	RNA polymerase_Homo sapiens_hsa03020	1.86882985
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.86435653
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.81610030
19	Propanoate metabolism_Homo sapiens_hsa00640	1.79697812
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.74345650
21	RNA degradation_Homo sapiens_hsa03018	1.73577436
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.73461098
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.69740399
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56709176
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53539478
26	Huntingtons disease_Homo sapiens_hsa05016	1.48093499
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47012179
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.42374295
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.41091763
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35528884
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.32148965
32	Taste transduction_Homo sapiens_hsa04742	1.28915335
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23737310
34	Morphine addiction_Homo sapiens_hsa05032	1.23538124
35	Alzheimers disease_Homo sapiens_hsa05010	1.22213333
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.22203363
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20692922
38	Olfactory transduction_Homo sapiens_hsa04740	1.18024944
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.17729672
40	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15027689
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14822481
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.05585785
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.04443567
44	Peroxisome_Homo sapiens_hsa04146	1.04186766
45	GABAergic synapse_Homo sapiens_hsa04727	1.01126427
46	Asthma_Homo sapiens_hsa05310	0.94540123
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.90255569
48	One carbon pool by folate_Homo sapiens_hsa00670	0.89330444
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.85718756
50	Proteasome_Homo sapiens_hsa03050	0.84301209
51	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.84072076
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.81676202
53	Insulin secretion_Homo sapiens_hsa04911	0.81428792
54	Regulation of autophagy_Homo sapiens_hsa04140	0.81320699
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78490646
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78435200
57	Serotonergic synapse_Homo sapiens_hsa04726	0.78078794
58	RNA transport_Homo sapiens_hsa03013	0.77774553
59	Circadian entrainment_Homo sapiens_hsa04713	0.77362668
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75989451
61	Ribosome_Homo sapiens_hsa03010	0.74728243
62	ABC transporters_Homo sapiens_hsa02010	0.72236687
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71140890
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71065851
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71001204
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63877388
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.60713738
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60086237
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.58698355
70	Mismatch repair_Homo sapiens_hsa03430	0.57927856
71	Purine metabolism_Homo sapiens_hsa00230	0.57651661
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56085262
73	Metabolic pathways_Homo sapiens_hsa01100	0.56018306
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.53352672
75	Allograft rejection_Homo sapiens_hsa05330	0.52606703
76	Retinol metabolism_Homo sapiens_hsa00830	0.51957623
77	Circadian rhythm_Homo sapiens_hsa04710	0.51855928
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51471729
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49838905
80	Fatty acid elongation_Homo sapiens_hsa00062	0.49213938
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48824733
82	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47943509
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47502378
84	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.47128628
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46726880
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45842784
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45239520
88	p53 signaling pathway_Homo sapiens_hsa04115	0.44481519
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.43726079
90	Salivary secretion_Homo sapiens_hsa04970	0.41222191
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40677433
92	Cocaine addiction_Homo sapiens_hsa05030	0.39981511
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39561985
94	Cholinergic synapse_Homo sapiens_hsa04725	0.37280421
95	Fatty acid degradation_Homo sapiens_hsa00071	0.36892210
96	Lysine degradation_Homo sapiens_hsa00310	0.36422265
97	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34029843
98	Base excision repair_Homo sapiens_hsa03410	0.32432558
99	Sulfur metabolism_Homo sapiens_hsa00920	0.31958817
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31754548

ZNF461

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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