ZNF462

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to C2H2-type zinc finger family of proteins. It contains multiple C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.07430990
2pyrimidine nucleobase catabolic process (GO:0006208)3.92163468
3limb bud formation (GO:0060174)3.76303247
4somite development (GO:0061053)3.64699368
5presynaptic membrane organization (GO:0097090)3.64364410
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.50265971
7regulation of translation, ncRNA-mediated (GO:0045974)3.50265971
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.50265971
9regulation of gene silencing by RNA (GO:0060966)3.49237065
10regulation of posttranscriptional gene silencing (GO:0060147)3.49237065
11regulation of gene silencing by miRNA (GO:0060964)3.49237065
12lateral sprouting from an epithelium (GO:0060601)3.23317193
13behavioral response to nicotine (GO:0035095)3.18950966
14artery development (GO:0060840)3.18789344
15cell proliferation in forebrain (GO:0021846)3.17992645
16axonal fasciculation (GO:0007413)3.11062103
17retinal ganglion cell axon guidance (GO:0031290)3.07098733
18otic vesicle formation (GO:0030916)3.05530362
19nucleobase catabolic process (GO:0046113)3.05489130
20spinal cord development (GO:0021510)3.03563166
21neuron cell-cell adhesion (GO:0007158)2.98567448
22neuron recognition (GO:0008038)2.92363218
23postsynaptic membrane organization (GO:0001941)2.86416796
24neuronal stem cell maintenance (GO:0097150)2.85529355
25kidney morphogenesis (GO:0060993)2.83183587
26hindbrain development (GO:0030902)2.81253628
27pre-miRNA processing (GO:0031054)2.76848168
28forebrain neuron differentiation (GO:0021879)2.74219375
29paraxial mesoderm development (GO:0048339)2.74165230
30central nervous system projection neuron axonogenesis (GO:0021952)2.69200792
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68964026
32dorsal/ventral axis specification (GO:0009950)2.67429619
33dendritic spine morphogenesis (GO:0060997)2.66049784
34vocalization behavior (GO:0071625)2.64803704
35nonmotile primary cilium assembly (GO:0035058)2.60979915
36limb development (GO:0060173)2.58542686
37appendage development (GO:0048736)2.58542686
38thalamus development (GO:0021794)2.58277168
39regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57563050
40protein localization to synapse (GO:0035418)2.55752496
41regulation of non-canonical Wnt signaling pathway (GO:2000050)2.55643350
42regulation of telomere maintenance (GO:0032204)2.55505905
43cerebral cortex radially oriented cell migration (GO:0021799)2.51648472
44pituitary gland development (GO:0021983)2.50870838
45transmission of nerve impulse (GO:0019226)2.50332992
46calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.45685065
47DNA damage response, detection of DNA damage (GO:0042769)2.40809896
48lung-associated mesenchyme development (GO:0060484)2.40261258
49regulation of development, heterochronic (GO:0040034)2.39913358
50synapse assembly (GO:0007416)2.39010829
51cell migration in hindbrain (GO:0021535)2.38976249
52protein polyglutamylation (GO:0018095)2.38388949
53olfactory bulb development (GO:0021772)2.36701857
54spinal cord motor neuron differentiation (GO:0021522)2.33831769
55regulation of timing of cell differentiation (GO:0048505)2.32331674
56intraciliary transport (GO:0042073)2.30932253
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30743795
58negative regulation of glial cell differentiation (GO:0045686)2.29696704
59cellular response to cholesterol (GO:0071397)2.27396513
60sympathetic nervous system development (GO:0048485)2.27170208
61regulation of hippo signaling (GO:0035330)2.26413245
62regulation of mesoderm development (GO:2000380)2.26370237
63negative regulation of astrocyte differentiation (GO:0048712)2.26294337
64prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.25722493
65positive regulation of synapse assembly (GO:0051965)2.25145453
66neuron fate determination (GO:0048664)2.24876873
67epithelial cilium movement (GO:0003351)2.24393039
68head development (GO:0060322)2.24237935
69negative regulation of transcription regulatory region DNA binding (GO:2000678)2.24130740
70auditory behavior (GO:0031223)2.22881132
71central nervous system neuron axonogenesis (GO:0021955)2.21800059
72atrial cardiac muscle cell action potential (GO:0086014)2.20463369
73negative regulation of axon guidance (GO:1902668)2.19860686
74generation of neurons (GO:0048699)2.18552788
75dendrite morphogenesis (GO:0048813)2.18232470
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.17853294
77positive regulation of gastrulation (GO:2000543)2.17365111
78ganglion development (GO:0061548)2.17257440
79mechanosensory behavior (GO:0007638)2.16021989
80chromatin remodeling at centromere (GO:0031055)2.15152887
81midbrain development (GO:0030901)2.14534121
82lymphangiogenesis (GO:0001946)2.14477003
83cell differentiation in spinal cord (GO:0021515)2.14320603
84gastrulation with mouth forming second (GO:0001702)2.14107674
85inner ear receptor cell development (GO:0060119)2.13436158
86gamma-aminobutyric acid transport (GO:0015812)2.12992095
87somite rostral/caudal axis specification (GO:0032525)2.12011688
88homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.10603601
89outer ear morphogenesis (GO:0042473)2.10426930
90hippocampus development (GO:0021766)2.10102025
91cornea development in camera-type eye (GO:0061303)2.10087346
92regulation of axon guidance (GO:1902667)2.09967638
93negative regulation of oligodendrocyte differentiation (GO:0048715)2.09734735
94regulation of collateral sprouting (GO:0048670)2.09183089
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.08997678
96organ growth (GO:0035265)2.08805944
97neuron migration (GO:0001764)2.07494940
98DNA double-strand break processing (GO:0000729)2.07352518
99cranial nerve development (GO:0021545)2.07211958
100hindlimb morphogenesis (GO:0035137)2.07046697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.47269949
2GBX2_23144817_ChIP-Seq_PC3_Human3.09041567
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.97104609
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86935107
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86548227
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58398228
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35670110
8ZNF274_21170338_ChIP-Seq_K562_Hela2.34561273
9FUS_26573619_Chip-Seq_HEK293_Human2.19906019
10TAF15_26573619_Chip-Seq_HEK293_Human2.14813121
11IGF1R_20145208_ChIP-Seq_DFB_Human2.14808072
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.14556860
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10887567
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.07370580
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03732432
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.00577715
17* P300_19829295_ChIP-Seq_ESCs_Human1.99726350
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98696865
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98202634
20EWS_26573619_Chip-Seq_HEK293_Human1.97415629
21VDR_22108803_ChIP-Seq_LS180_Human1.97354404
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95623485
23* PIAS1_25552417_ChIP-Seq_VCAP_Human1.93505607
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87677794
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.84842959
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73523914
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73523914
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.73071699
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71879409
30* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69790348
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68942401
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68510391
33RNF2_27304074_Chip-Seq_NSC_Mouse1.65690054
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65009932
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.57735223
36* SMAD3_21741376_ChIP-Seq_EPCs_Human1.56609178
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53565420
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52174608
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50737526
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50294581
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.47423919
42REST_21632747_ChIP-Seq_MESCs_Mouse1.47021862
43* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46376418
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44714144
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.44580282
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43287692
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41751257
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40191333
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37777387
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33938040
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33759710
52* AR_25329375_ChIP-Seq_VCAP_Human1.31607320
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30703452
54* STAT3_23295773_ChIP-Seq_U87_Human1.27587183
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26617330
56* AR_21572438_ChIP-Seq_LNCaP_Human1.25470279
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.25401196
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24851375
59* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24805035
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23204764
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23204764
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22204626
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20163459
64STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19923416
65TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19523903
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19453055
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19387672
68TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19385386
69TCF4_23295773_ChIP-Seq_U87_Human1.19228001
70* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18148730
71* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18099614
72SOX9_26525672_Chip-Seq_HEART_Mouse1.17805576
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.16362585
74CBP_20019798_ChIP-Seq_JUKART_Human1.15844994
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15844994
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.14781330
77ER_23166858_ChIP-Seq_MCF-7_Human1.13990673
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13557372
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12171399
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12044628
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11493937
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.10469379
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10117640
84BCAT_22108803_ChIP-Seq_LS180_Human1.07533747
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06343117
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05922144
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.05241792
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.04741678
89POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04483525
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.04302541
91* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03954441
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03888026
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03855879
94MYC_18940864_ChIP-ChIP_HL60_Human1.03306202
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.01817251
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00561053
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.00317644
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99296908
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.97199986
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96797754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.08247900
2MP0000778_abnormal_nervous_system2.35332795
3MP0003890_abnormal_embryonic-extraembry2.26833937
4MP0003136_yellow_coat_color2.13747633
5MP0000537_abnormal_urethra_morphology2.12918392
6MP0000566_synostosis1.95286054
7MP0000631_abnormal_neuroendocrine_gland1.90015517
8MP0001293_anophthalmia1.88641499
9MP0004270_analgesia1.85745303
10MP0003880_abnormal_central_pattern1.85276489
11MP0004133_heterotaxia1.84470988
12MP0000049_abnormal_middle_ear1.83199810
13MP0003122_maternal_imprinting1.82625282
14MP0003937_abnormal_limbs/digits/tail_de1.81848155
15MP0002938_white_spotting1.80426919
16MP0002822_catalepsy1.74814002
17MP0003121_genomic_imprinting1.71940223
18MP0003787_abnormal_imprinting1.67592604
19MP0008877_abnormal_DNA_methylation1.66720008
20MP0008789_abnormal_olfactory_epithelium1.64546969
21MP0003119_abnormal_digestive_system1.60977173
22MP0010030_abnormal_orbit_morphology1.60892911
23MP0001529_abnormal_vocalization1.60633635
24MP0006072_abnormal_retinal_apoptosis1.59868829
25MP0003283_abnormal_digestive_organ1.56861230
26MP0002653_abnormal_ependyma_morphology1.56812340
27MP0005499_abnormal_olfactory_system1.54234694
28MP0005394_taste/olfaction_phenotype1.54234694
29MP0002102_abnormal_ear_morphology1.52056968
30MP0002234_abnormal_pharynx_morphology1.49163699
31MP0001984_abnormal_olfaction1.47840185
32MP0004145_abnormal_muscle_electrophysio1.47755469
33MP0003938_abnormal_ear_development1.47373482
34MP0005187_abnormal_penis_morphology1.46121331
35MP0001485_abnormal_pinna_reflex1.44485192
36MP0002233_abnormal_nose_morphology1.43196163
37MP0001188_hyperpigmentation1.43086078
38MP0006276_abnormal_autonomic_nervous1.42199826
39MP0002751_abnormal_autonomic_nervous1.40109692
40MP0002735_abnormal_chemical_nociception1.37430722
41MP0002697_abnormal_eye_size1.37012875
42MP0002184_abnormal_innervation1.35863794
43MP0002736_abnormal_nociception_after1.34559147
44MP0001486_abnormal_startle_reflex1.34269260
45MP0003861_abnormal_nervous_system1.32319268
46MP0002734_abnormal_mechanical_nocicepti1.31720036
47MP0002638_abnormal_pupillary_reflex1.30888191
48MP0001286_abnormal_eye_development1.29341664
49MP0004885_abnormal_endolymph1.27672533
50MP0003755_abnormal_palate_morphology1.27299454
51MP0000955_abnormal_spinal_cord1.27049798
52MP0001299_abnormal_eye_distance/1.26549364
53MP0004859_abnormal_synaptic_plasticity1.25648394
54MP0003635_abnormal_synaptic_transmissio1.23535899
55MP0002272_abnormal_nervous_system1.22312401
56MP0002557_abnormal_social/conspecific_i1.21402579
57MP0003315_abnormal_perineum_morphology1.17822027
58MP0005646_abnormal_pituitary_gland1.17757229
59MP0001968_abnormal_touch/_nociception1.17369651
60MP0005551_abnormal_eye_electrophysiolog1.17022862
61MP0009745_abnormal_behavioral_response1.15256621
62MP0005253_abnormal_eye_physiology1.14780120
63MP0003941_abnormal_skin_development1.13123951
64MP0002572_abnormal_emotion/affect_behav1.11129326
65MP0002752_abnormal_somatic_nervous1.10137676
66MP0005423_abnormal_somatic_nervous1.09906539
67MP0002063_abnormal_learning/memory/cond1.09512128
68MP0009046_muscle_twitch1.09276495
69MP0002152_abnormal_brain_morphology1.08289620
70MP0000026_abnormal_inner_ear1.08070095
71MP0003567_abnormal_fetal_cardiomyocyte1.06231756
72MP0003942_abnormal_urinary_system1.03922705
73MP0005645_abnormal_hypothalamus_physiol1.03392554
74MP0000428_abnormal_craniofacial_morphol1.01014994
75MP0002882_abnormal_neuron_morphology0.99982459
76MP0009250_abnormal_appendicular_skeleto0.98749740
77MP0005391_vision/eye_phenotype0.98375512
78MP0009053_abnormal_anal_canal0.96985272
79MP0003935_abnormal_craniofacial_develop0.96719439
80MP0005248_abnormal_Harderian_gland0.95835872
81MP0000647_abnormal_sebaceous_gland0.94245868
82MP0000534_abnormal_ureter_morphology0.93853628
83MP0002064_seizures0.93826821
84MP0002116_abnormal_craniofacial_bone0.92912056
85MP0000569_abnormal_digit_pigmentation0.92737583
86MP0005195_abnormal_posterior_eye0.92390963
87MP0004142_abnormal_muscle_tone0.90592967
88MP0002067_abnormal_sensory_capabilities0.87922141
89MP0000383_abnormal_hair_follicle0.87170057
90MP0003385_abnormal_body_wall0.86464368
91MP0000579_abnormal_nail_morphology0.85995065
92MP0004924_abnormal_behavior0.85963238
93MP0005386_behavior/neurological_phenoty0.85963238
94MP0002111_abnormal_tail_morphology0.85571693
95MP0004742_abnormal_vestibular_system0.84322828
96MP0003011_delayed_dark_adaptation0.84245951
97MP0002084_abnormal_developmental_patter0.83199804
98MP0002081_perinatal_lethality0.82070558
99MP0002160_abnormal_reproductive_system0.80335387
100MP0000432_abnormal_head_morphology0.80029428

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.29185855
2Abnormality of the labia minora (HP:0012880)3.08241369
3Hepatoblastoma (HP:0002884)2.67956885
4Colon cancer (HP:0003003)2.64488958
5Esophageal atresia (HP:0002032)2.60654899
6Optic nerve hypoplasia (HP:0000609)2.60216626
7True hermaphroditism (HP:0010459)2.59908330
8Intestinal atresia (HP:0011100)2.56835710
9Bilateral microphthalmos (HP:0007633)2.55614053
10Anophthalmia (HP:0000528)2.54645897
11Pancreatic fibrosis (HP:0100732)2.54462561
12Nephronophthisis (HP:0000090)2.47005488
13Cutaneous finger syndactyly (HP:0010554)2.46923631
14Pancreatic cysts (HP:0001737)2.46012426
15Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.37758984
16Aplasia/Hypoplasia of the sternum (HP:0006714)2.34436752
17Abnormality of midbrain morphology (HP:0002418)2.29236152
18Molar tooth sign on MRI (HP:0002419)2.29236152
19Gastrointestinal atresia (HP:0002589)2.29017237
20Oligodactyly (hands) (HP:0001180)2.20872462
21Genetic anticipation (HP:0003743)2.19858921
22Cutaneous syndactyly (HP:0012725)2.18466099
23Renal hypoplasia (HP:0000089)2.16084060
24Midline defect of the nose (HP:0004122)2.15240278
25Genital tract atresia (HP:0001827)2.14068166
26Vaginal atresia (HP:0000148)2.14010726
27Hyperventilation (HP:0002883)2.12024743
28Pendular nystagmus (HP:0012043)2.09601769
29Morphological abnormality of the middle ear (HP:0008609)2.07049036
30Broad-based gait (HP:0002136)2.05692885
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04519834
32Short 4th metacarpal (HP:0010044)2.04519834
33Abnormality of the renal medulla (HP:0100957)2.04280425
34Medial flaring of the eyebrow (HP:0010747)2.03394822
35Type II lissencephaly (HP:0007260)2.02533556
36Bifid tongue (HP:0010297)2.00891809
37Drooling (HP:0002307)1.99404782
38Absent septum pellucidum (HP:0001331)1.96026847
39Progressive cerebellar ataxia (HP:0002073)1.94433254
40Gait imbalance (HP:0002141)1.93089278
41Chronic hepatic failure (HP:0100626)1.92109433
42Volvulus (HP:0002580)1.91519009
43Labial hypoplasia (HP:0000066)1.91237862
44High anterior hairline (HP:0009890)1.90688912
45Abnormal number of incisors (HP:0011064)1.90380808
46Lissencephaly (HP:0001339)1.90295622
47Anencephaly (HP:0002323)1.89088804
48Sclerocornea (HP:0000647)1.87992686
49Maternal diabetes (HP:0009800)1.87821685
50Abnormality of the septum pellucidum (HP:0007375)1.87189097
51Aqueductal stenosis (HP:0002410)1.83118811
52Limb dystonia (HP:0002451)1.81421657
53Ectopic kidney (HP:0000086)1.79683928
54Abnormality of the aortic arch (HP:0012303)1.77668877
55Postaxial hand polydactyly (HP:0001162)1.76853447
56Preaxial foot polydactyly (HP:0001841)1.75051057
57Cupped ear (HP:0000378)1.75045099
58Hypoplastic female external genitalia (HP:0012815)1.73558902
59Micropenis (HP:0000054)1.73024827
60Congenital primary aphakia (HP:0007707)1.72541251
61Cystic liver disease (HP:0006706)1.72125396
62Myokymia (HP:0002411)1.72082608
63Abnormality of the pubic bones (HP:0003172)1.71488957
64Patellar aplasia (HP:0006443)1.70497332
65Oligodactyly (HP:0012165)1.70217783
66Preaxial hand polydactyly (HP:0001177)1.70083386
67Vitreoretinal degeneration (HP:0000655)1.69967873
68Excessive salivation (HP:0003781)1.69662631
69Small hand (HP:0200055)1.67567633
70Hemivertebrae (HP:0002937)1.67284005
71Retinal dysplasia (HP:0007973)1.67111686
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.65534669
73Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65235584
74Short hallux (HP:0010109)1.64778818
75Focal motor seizures (HP:0011153)1.64372583
76Scrotal hypoplasia (HP:0000046)1.64006357
77Aplasia/Hypoplasia of the hallux (HP:0008362)1.63012836
78Dandy-Walker malformation (HP:0001305)1.62761655
79Aplasia/Hypoplasia of the patella (HP:0006498)1.61929701
80Rib fusion (HP:0000902)1.61290824
81Specific learning disability (HP:0001328)1.61261952
82Abnormality of the 4th metacarpal (HP:0010012)1.60931877
83Stenosis of the external auditory canal (HP:0000402)1.60795720
84Poor coordination (HP:0002370)1.60172431
85Protruding tongue (HP:0010808)1.60123131
86Nephrogenic diabetes insipidus (HP:0009806)1.60011854
87Growth hormone deficiency (HP:0000824)1.59158420
88Thyroid-stimulating hormone excess (HP:0002925)1.57811654
89Pachygyria (HP:0001302)1.55711562
90Postaxial foot polydactyly (HP:0001830)1.55648452
91Hypoplastic labia majora (HP:0000059)1.55233046
92Abnormality of the proximal phalanges of the hand (HP:0009834)1.54496130
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.53693921
94Abnormality of the middle phalanges of the toes (HP:0010183)1.53076450
95Partial agenesis of the corpus callosum (HP:0001338)1.52944777
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.52608622
97Neoplasm of the adrenal cortex (HP:0100641)1.52578329
98Synostosis of carpal bones (HP:0005048)1.52570896
99Shawl scrotum (HP:0000049)1.52538136
100Gaze-evoked nystagmus (HP:0000640)1.51671799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.65217201
2MARK13.22004376
3TNIK2.88103085
4WNK32.66716307
5PNCK2.53052503
6MAP3K42.27400542
7CAMK1G2.06953606
8MKNK21.99113343
9DYRK21.94319037
10FRK1.91974069
11CAMK1D1.84704206
12BMPR1B1.73622523
13BCR1.72620109
14MAPK131.69633334
15CDC71.68594987
16MAP4K21.61493469
17ZAK1.60953525
18PINK11.58675421
19EPHB21.57115769
20MKNK11.55614875
21MAP2K71.54519039
22EPHA41.52421303
23FGFR21.44416514
24NTRK21.39225678
25DYRK31.39074770
26NUAK11.38772873
27LATS11.33848181
28GRK11.31270618
29STK38L1.30927019
30CSNK1G11.29899050
31SRPK11.28967903
32CSNK1G21.24390898
33TAF11.19354041
34INSRR1.18783426
35ADRBK21.14883127
36VRK11.08855362
37CSNK1A1L1.04031381
38SGK21.01733858
39CSNK1G31.01030208
40TLK11.00574846
41PLK30.98915554
42PRKCG0.95648088
43AKT30.95140618
44SGK2230.94918032
45SGK4940.94918032
46TRIM280.93766043
47OBSCN0.93325089
48PAK30.89489375
49NME10.88314542
50NTRK30.86108931
51ACVR1B0.84737771
52TSSK60.83257711
53VRK20.83000758
54MINK10.82725540
55WEE10.82466255
56PLK40.80719033
57CDK190.79684124
58PRKCE0.76143669
59PLK20.73909147
60BRD40.73461472
61CDK30.73225079
62PHKG10.72203737
63PHKG20.72203737
64OXSR10.71642496
65NEK20.70950709
66PLK10.68019306
67UHMK10.67584093
68BRSK20.66053127
69EPHA30.65243654
70TTK0.64627355
71STK30.64200297
72ATR0.63131552
73DYRK1A0.62994993
74CSNK1E0.60982957
75MAPK150.60749572
76FGFR10.58252495
77ATM0.57029813
78TAOK10.56306572
79LATS20.56093455
80STK390.55601463
81PKN10.55114949
82CSNK1A10.54563520
83CHEK20.53978275
84STK110.53464330
85ERBB30.52961012
86ERBB20.52884734
87NLK0.52231823
88CAMK10.51379450
89CDK50.49744480
90TGFBR10.48227354
91BUB10.47959178
92RPS6KA40.47564853
93MAP2K40.46362430
94CAMK2A0.46041692
95TIE10.44890542
96WNK40.44076200
97PRKAA10.43912250
98CSNK1D0.43720929
99STK160.43037215
100PRKDC0.42955341

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.86547524
2Basal cell carcinoma_Homo sapiens_hsa052172.33203727
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12595320
4Hedgehog signaling pathway_Homo sapiens_hsa043402.09482296
5Phototransduction_Homo sapiens_hsa047441.93556507
6Oxidative phosphorylation_Homo sapiens_hsa001901.75266891
7Basal transcription factors_Homo sapiens_hsa030221.69343364
8Protein export_Homo sapiens_hsa030601.64574488
9Hippo signaling pathway_Homo sapiens_hsa043901.64439314
10RNA polymerase_Homo sapiens_hsa030201.63803143
11Cardiac muscle contraction_Homo sapiens_hsa042601.60981519
12Axon guidance_Homo sapiens_hsa043601.58603152
13Selenocompound metabolism_Homo sapiens_hsa004501.57044131
14Taste transduction_Homo sapiens_hsa047421.53903831
15Glutamatergic synapse_Homo sapiens_hsa047241.50957491
16Parkinsons disease_Homo sapiens_hsa050121.50765628
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.48210745
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45824287
19Fanconi anemia pathway_Homo sapiens_hsa034601.45049716
20Wnt signaling pathway_Homo sapiens_hsa043101.43172803
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42661550
22Circadian entrainment_Homo sapiens_hsa047131.40791913
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39946968
24GABAergic synapse_Homo sapiens_hsa047271.37871447
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37165487
26Huntingtons disease_Homo sapiens_hsa050161.35852383
27Steroid biosynthesis_Homo sapiens_hsa001001.35438981
28RNA degradation_Homo sapiens_hsa030181.34037465
29Non-homologous end-joining_Homo sapiens_hsa034501.32831343
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31585293
31Morphine addiction_Homo sapiens_hsa050321.23548919
32Dopaminergic synapse_Homo sapiens_hsa047281.23518812
33Homologous recombination_Homo sapiens_hsa034401.23018333
34Butanoate metabolism_Homo sapiens_hsa006501.20207682
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20196141
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18084299
37Propanoate metabolism_Homo sapiens_hsa006401.17820429
38Insulin secretion_Homo sapiens_hsa049111.15976113
39Alzheimers disease_Homo sapiens_hsa050101.12821496
40Tight junction_Homo sapiens_hsa045301.11324536
41Serotonergic synapse_Homo sapiens_hsa047261.10231626
42Cocaine addiction_Homo sapiens_hsa050301.10222834
43TGF-beta signaling pathway_Homo sapiens_hsa043501.06885307
44mRNA surveillance pathway_Homo sapiens_hsa030151.05705930
45Long-term depression_Homo sapiens_hsa047301.05229346
46Spliceosome_Homo sapiens_hsa030401.02966369
47Olfactory transduction_Homo sapiens_hsa047401.02224364
48RNA transport_Homo sapiens_hsa030131.00939245
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98347152
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95619213
51Melanogenesis_Homo sapiens_hsa049160.94395572
52Mismatch repair_Homo sapiens_hsa034300.94370704
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92464365
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90768742
55Amphetamine addiction_Homo sapiens_hsa050310.90472772
56Linoleic acid metabolism_Homo sapiens_hsa005910.90212745
57Oocyte meiosis_Homo sapiens_hsa041140.88583628
58Alcoholism_Homo sapiens_hsa050340.87471464
59Ribosome_Homo sapiens_hsa030100.87343503
60Circadian rhythm_Homo sapiens_hsa047100.86686559
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85946956
62Lysine degradation_Homo sapiens_hsa003100.83094768
63Cholinergic synapse_Homo sapiens_hsa047250.81686345
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80920203
65Nitrogen metabolism_Homo sapiens_hsa009100.80222540
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76845518
67Adherens junction_Homo sapiens_hsa045200.75782309
68Tryptophan metabolism_Homo sapiens_hsa003800.74866475
69Fatty acid biosynthesis_Homo sapiens_hsa000610.73639990
70Ether lipid metabolism_Homo sapiens_hsa005650.73633794
71Gap junction_Homo sapiens_hsa045400.73050739
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69563639
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69044204
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68678224
75cAMP signaling pathway_Homo sapiens_hsa040240.68224654
76Vitamin digestion and absorption_Homo sapiens_hsa049770.66730855
77Cell cycle_Homo sapiens_hsa041100.66373743
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65695264
79Dilated cardiomyopathy_Homo sapiens_hsa054140.63036242
80Purine metabolism_Homo sapiens_hsa002300.60024560
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59668430
82Base excision repair_Homo sapiens_hsa034100.58541448
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57730392
84Renin secretion_Homo sapiens_hsa049240.57051702
85Salivary secretion_Homo sapiens_hsa049700.55230817
86Calcium signaling pathway_Homo sapiens_hsa040200.53905814
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.52980517
88Melanoma_Homo sapiens_hsa052180.52677459
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52264086
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.51870244
91Nucleotide excision repair_Homo sapiens_hsa034200.51452303
92Retinol metabolism_Homo sapiens_hsa008300.51393357
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49962817
94Oxytocin signaling pathway_Homo sapiens_hsa049210.49242170
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48897402
96Gastric acid secretion_Homo sapiens_hsa049710.47705682
97beta-Alanine metabolism_Homo sapiens_hsa004100.47473331
98Dorso-ventral axis formation_Homo sapiens_hsa043200.43773777
99Ovarian steroidogenesis_Homo sapiens_hsa049130.43260865
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43078053

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »