ZNF467

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.14454961
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.14454961
3modulation by symbiont of host immune response (GO:0052553)6.14454961
4positive regulation by symbiont of host defense response (GO:0052509)6.14454961
5modulation by symbiont of host defense response (GO:0052031)6.14454961
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.14454961
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.93308716
8negative regulation of cell killing (GO:0031342)5.93308716
9neutrophil activation involved in immune response (GO:0002283)5.72073024
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.47373546
11detection of other organism (GO:0098543)5.31425516
12response to peptidoglycan (GO:0032494)5.22954382
13detection of bacterium (GO:0016045)5.17979747
14positive regulation of gamma-delta T cell activation (GO:0046645)5.13496243
15antigen processing and presentation of endogenous antigen (GO:0019883)4.95050962
16macrophage activation involved in immune response (GO:0002281)4.94137886
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.79701590
18leukocyte aggregation (GO:0070486)4.78358156
19leukocyte migration involved in inflammatory response (GO:0002523)4.67397586
20detection of external biotic stimulus (GO:0098581)4.49678413
21neutrophil activation (GO:0042119)4.44872497
22respiratory burst (GO:0045730)4.36268624
23cellular extravasation (GO:0045123)4.31914693
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.25000282
25negative regulation of interleukin-12 production (GO:0032695)4.24901432
26detection of molecule of bacterial origin (GO:0032490)4.23579021
27response to host immune response (GO:0052572)4.21704888
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.21704888
29regulation of interferon-beta biosynthetic process (GO:0045357)4.11776424
30immunoglobulin mediated immune response (GO:0016064)4.08936801
31regulation of B cell receptor signaling pathway (GO:0050855)4.04759661
32negative regulation of lymphocyte mediated immunity (GO:0002707)4.03133684
33detection of biotic stimulus (GO:0009595)4.01715341
34granulocyte activation (GO:0036230)4.00246351
35negative regulation of erythrocyte differentiation (GO:0045647)3.94986748
36regulation of mast cell degranulation (GO:0043304)3.93591737
37regulation of gamma-delta T cell activation (GO:0046643)3.86314702
38response to host (GO:0075136)3.84970519
39response to host defenses (GO:0052200)3.84970519
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.84970519
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.77257591
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75183691
43myeloid cell activation involved in immune response (GO:0002275)3.71142538
44regulation of myeloid leukocyte mediated immunity (GO:0002886)3.70669734
45macrophage activation (GO:0042116)3.69728472
46microglial cell activation (GO:0001774)3.69595875
47neutrophil mediated immunity (GO:0002446)3.69553154
48regulation of mast cell activation involved in immune response (GO:0033006)3.59564670
49negative regulation of leukocyte mediated immunity (GO:0002704)3.58155048
50regulation of leukocyte degranulation (GO:0043300)3.54993596
51positive regulation of mast cell activation (GO:0033005)3.46461194
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43159802
53leukocyte degranulation (GO:0043299)3.42662694
54response to interleukin-15 (GO:0070672)3.33819983
55regulation of mast cell activation (GO:0033003)3.33424968
56regulation of T-helper 2 cell differentiation (GO:0045628)3.33352384
57response to muramyl dipeptide (GO:0032495)3.32609152
58negative regulation of phagocytosis (GO:0050765)3.32562500
59production of molecular mediator involved in inflammatory response (GO:0002532)3.30377286
60regulation of regulated secretory pathway (GO:1903305)3.25878462
61negative regulation of T cell mediated immunity (GO:0002710)3.24235392
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.21434356
63regulation of gamma-delta T cell differentiation (GO:0045586)3.20647433
64antigen processing and presentation via MHC class Ib (GO:0002475)3.19075580
65germinal center formation (GO:0002467)3.16958187
66myeloid leukocyte mediated immunity (GO:0002444)3.16834353
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.15475469
68negative regulation of interleukin-6 production (GO:0032715)3.10169074
69cellular response to type I interferon (GO:0071357)3.09677640
70type I interferon signaling pathway (GO:0060337)3.09677640
71response to type I interferon (GO:0034340)3.08640992
72defense response to protozoan (GO:0042832)3.04989694
73positive regulation of mast cell degranulation (GO:0043306)3.02674327
74positive regulation of mast cell activation involved in immune response (GO:0033008)3.02674327
75negative regulation of cytokine production involved in immune response (GO:0002719)3.02095362
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97086208
77regulation of T cell tolerance induction (GO:0002664)2.97063472
78cellular response to interleukin-15 (GO:0071350)2.96357052
79B cell mediated immunity (GO:0019724)2.95564958
80neutrophil chemotaxis (GO:0030593)2.95100146
81lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95096493
82regulation of tolerance induction (GO:0002643)2.93767641
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93137243
84negative regulation of type 2 immune response (GO:0002829)2.90612408
85B cell receptor signaling pathway (GO:0050853)2.88758512
86positive regulation of regulated secretory pathway (GO:1903307)2.87591825
87neutrophil migration (GO:1990266)2.87481475
88negative regulation of innate immune response (GO:0045824)2.82953906
89tolerance induction (GO:0002507)2.79575674
90interferon-gamma-mediated signaling pathway (GO:0060333)2.77114747
91myeloid leukocyte activation (GO:0002274)2.76978786
92actin filament polymerization (GO:0030041)2.74588526
93positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.74069287
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.73352494
95response to protozoan (GO:0001562)2.71627932
96positive regulation of cellular amide metabolic process (GO:0034250)2.70800205
97negative regulation of glycoprotein biosynthetic process (GO:0010561)2.69996661
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69915336
99positive thymic T cell selection (GO:0045059)2.69861152
100regulation of B cell differentiation (GO:0045577)2.67904532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.06631813
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.54391068
3VDR_21846776_ChIP-Seq_THP-1_Human3.35320494
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01798098
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.90033553
6VDR_24763502_ChIP-Seq_THP-1_Human2.68044516
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.57830366
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53037703
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48166071
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44311252
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42821218
12SPI1_23127762_ChIP-Seq_K562_Human2.38659855
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35083345
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.31698273
15MYC_22102868_ChIP-Seq_BL_Human2.30984715
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.27835656
17LXR_22292898_ChIP-Seq_THP-1_Human2.27384670
18TCF7_22412390_ChIP-Seq_EML_Mouse2.25606231
19SPI1_23547873_ChIP-Seq_NB4_Human2.25533922
20MAF_26560356_Chip-Seq_TH1_Human2.24730208
21* KDM2B_26808549_Chip-Seq_DND41_Human2.22366027
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17270436
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16973161
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.15905389
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15213919
26UTX_26944678_Chip-Seq_JUKART_Human2.06751121
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02297476
28ELK3_25401928_ChIP-Seq_HUVEC_Human2.01589115
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98358395
30SCL_19346495_ChIP-Seq_HPC-7_Human1.92841100
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91854178
32* MAF_26560356_Chip-Seq_TH2_Human1.89504701
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77461954
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77093774
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75831837
36RUNX_20019798_ChIP-Seq_JUKART_Human1.71918951
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67935283
38RACK7_27058665_Chip-Seq_MCF-7_Human1.64849338
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63456313
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62341040
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.58259898
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57879266
43BCL6_27268052_Chip-Seq_Bcells_Human1.56311738
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55787129
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53441836
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.52341160
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51236172
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49738267
49P68_20966046_ChIP-Seq_HELA_Human1.48818863
50BCOR_27268052_Chip-Seq_Bcells_Human1.46599329
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44698505
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41669267
53MYB_26560356_Chip-Seq_TH1_Human1.40638097
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39990913
55* KDM2B_26808549_Chip-Seq_K562_Human1.38793343
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.38581334
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38491031
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38112557
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37314145
60MYB_26560356_Chip-Seq_TH2_Human1.36231881
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35809796
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35354951
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35193402
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34398772
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33956739
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33731900
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32853803
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.30933736
69* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28359076
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.23759500
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23691235
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19927834
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19866907
74SMC4_20622854_ChIP-Seq_HELA_Human1.19844946
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17902970
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17131583
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15231685
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.14899600
79VDR_24787735_ChIP-Seq_THP-1_Human1.14668899
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.13541912
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13180055
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10672747
83E2F1_20622854_ChIP-Seq_HELA_Human1.10404248
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08921764
85GATA1_19941826_ChIP-Seq_K562_Human1.08133094
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08078725
87NCOR1_26117541_ChIP-Seq_K562_Human1.07970411
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.07713368
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07508908
90GATA3_27048872_Chip-Seq_THYMUS_Human1.07451129
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05993098
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05444294
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05324655
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04184104
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01413459
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99793306
97PHF8_20622854_ChIP-Seq_HELA_Human0.99586283
98CREB1_26743006_Chip-Seq_LNCaP_Human0.99301346
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97940583
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97598339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.01624518
2MP0003436_decreased_susceptibility_to4.53838912
3MP0003303_peritoneal_inflammation3.84641971
4MP0002419_abnormal_innate_immunity3.19212613
5MP0001835_abnormal_antigen_presentation3.18780560
6MP0005025_abnormal_response_to2.89049064
7MP0005387_immune_system_phenotype2.61559400
8MP0001790_abnormal_immune_system2.61559400
9MP0005000_abnormal_immune_tolerance2.57909230
10MP0001800_abnormal_humoral_immune2.57351881
11MP0006082_CNS_inflammation2.57276333
12MP0009785_altered_susceptibility_to2.57271604
13MP0000685_abnormal_immune_system2.50264455
14MP0003191_abnormal_cellular_cholesterol2.46973948
15MP0005671_abnormal_response_to2.42970040
16MP0002723_abnormal_immune_serum2.39892842
17MP0002420_abnormal_adaptive_immunity2.35610214
18MP0003172_abnormal_lysosome_physiology2.33816709
19MP0001819_abnormal_immune_cell2.33805870
20MP0009278_abnormal_bone_marrow2.33116804
21MP0008260_abnormal_autophagy2.29515435
22MP0001533_abnormal_skeleton_physiology2.28703618
23MP0002452_abnormal_antigen_presenting2.26221867
24MP0003300_gastrointestinal_ulcer2.15335837
25MP0002132_abnormal_respiratory_system2.10939970
26MP0002148_abnormal_hypersensitivity_rea2.08633581
27MP0003183_abnormal_peptide_metabolism1.99171151
28MP0005058_abnormal_lysosome_morphology1.98488757
29MP0005464_abnormal_platelet_physiology1.95078027
30MP0003828_pulmonary_edema1.88256312
31MP0002405_respiratory_system_inflammati1.85085862
32MP0005451_abnormal_body_composition1.74710614
33MP0010155_abnormal_intestine_physiology1.70762868
34MP0004381_abnormal_hair_follicle1.70105720
35MP0000716_abnormal_immune_system1.69740086
36MP0003866_abnormal_defecation1.68014172
37MP0001845_abnormal_inflammatory_respons1.67582803
38MP0002398_abnormal_bone_marrow1.65670928
39MP0002277_abnormal_respiratory_mucosa1.58958416
40MP0004947_skin_inflammation1.58304317
41MP0004510_myositis1.57162097
42MP0003763_abnormal_thymus_physiology1.48479120
43MP0000465_gastrointestinal_hemorrhage1.46343631
44MP0008469_abnormal_protein_level1.45723423
45MP0009333_abnormal_splenocyte_physiolog1.43134804
46MP0005083_abnormal_biliary_tract1.39071867
47MP0000689_abnormal_spleen_morphology1.38421436
48MP0009764_decreased_sensitivity_to1.37848371
49MP0005397_hematopoietic_system_phenotyp1.33795005
50MP0001545_abnormal_hematopoietic_system1.33795005
51MP0002722_abnormal_immune_system1.33610753
52MP0002429_abnormal_blood_cell1.32692118
53MP0005310_abnormal_salivary_gland1.31951371
54MP0003075_altered_response_to1.28065304
55MP0004858_abnormal_nervous_system1.20707403
56MP0002998_abnormal_bone_remodeling1.20536909
57MP0002396_abnormal_hematopoietic_system1.20457298
58MP0000703_abnormal_thymus_morphology1.18687767
59MP0000858_altered_metastatic_potential1.18241393
60MP0001851_eye_inflammation1.17025116
61MP0004883_abnormal_blood_vessel1.14757865
62MP0001873_stomach_inflammation1.14357280
63MP0003878_abnormal_ear_physiology1.14331546
64MP0005377_hearing/vestibular/ear_phenot1.14331546
65MP0002653_abnormal_ependyma_morphology1.01767788
66MP0005390_skeleton_phenotype1.00965606
67MP0003690_abnormal_glial_cell0.99820237
68MP0001663_abnormal_digestive_system0.97290729
69MP0001986_abnormal_taste_sensitivity0.96844486
70MP0005075_abnormal_melanosome_morpholog0.96833937
71MP0002138_abnormal_hepatobiliary_system0.96103632
72MP0005248_abnormal_Harderian_gland0.93489246
73MP0003806_abnormal_nucleotide_metabolis0.84645729
74MP0000343_altered_response_to0.81944899
75MP0005164_abnormal_response_to0.80060483
76MP0000490_abnormal_crypts_of0.79729671
77MP0005166_decreased_susceptibility_to0.78545857
78MP0008004_abnormal_stomach_pH0.76210912
79MP0002928_abnormal_bile_duct0.75789642
80MP0005076_abnormal_cell_differentiation0.75174118
81MP0004130_abnormal_muscle_cell0.74254754
82MP0000604_amyloidosis0.72660426
83MP0000470_abnormal_stomach_morphology0.69537031
84MP0002933_joint_inflammation0.69383512
85MP0005167_abnormal_blood-brain_barrier0.67601002
86MP0008874_decreased_physiological_sensi0.66773525
87MP0005319_abnormal_enzyme/_coenzyme0.63354637
88MP0003795_abnormal_bone_structure0.63094265
89MP0005381_digestive/alimentary_phenotyp0.61961621
90MP0002166_altered_tumor_susceptibility0.61893365
91MP0009765_abnormal_xenobiotic_induced0.58927281
92MP0003879_abnormal_hair_cell0.58613504
93MP0009763_increased_sensitivity_to0.57723957
94MP0002693_abnormal_pancreas_physiology0.57191307
95MP0000015_abnormal_ear_pigmentation0.56630280
96MP0001853_heart_inflammation0.55877193
97MP0009840_abnormal_foam_cell0.55494940
98MP0003787_abnormal_imprinting0.55118229
99MP0004264_abnormal_extraembryonic_tissu0.53927030
100MP0000678_abnormal_parathyroid_gland0.53247990

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.66613583
2Recurrent abscess formation (HP:0002722)6.15027368
3Recurrent bacterial skin infections (HP:0005406)5.90772244
4Myositis (HP:0100614)5.72369005
5Abnormality of macrophages (HP:0004311)5.63320467
6Orchitis (HP:0100796)5.29104871
7Recurrent gram-negative bacterial infections (HP:0005420)5.06127259
8Elevated erythrocyte sedimentation rate (HP:0003565)4.93124582
9Stomatitis (HP:0010280)4.73056817
10Retrobulbar optic neuritis (HP:0100654)4.69281378
11Optic neuritis (HP:0100653)4.69281378
12Obstructive lung disease (HP:0006536)4.60540521
13Chronic obstructive pulmonary disease (HP:0006510)4.60540521
14Hypochromic microcytic anemia (HP:0004840)4.52066510
15Gastrointestinal infarctions (HP:0005244)4.20321736
16Mediastinal lymphadenopathy (HP:0100721)4.05946175
17Hypochromic anemia (HP:0001931)4.02549552
18Increased IgE level (HP:0003212)4.00013608
19Recurrent fungal infections (HP:0002841)3.91005179
20Recurrent skin infections (HP:0001581)3.74780654
21Meningitis (HP:0001287)3.69702771
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.68872352
23Spontaneous hematomas (HP:0007420)3.63560619
24Urticaria (HP:0001025)3.52261791
25Gingivitis (HP:0000230)3.44410501
26Encephalitis (HP:0002383)3.40679260
27Prolonged bleeding time (HP:0003010)3.36641143
28Episodic fever (HP:0001954)3.28194965
29Keratoconjunctivitis sicca (HP:0001097)3.20012462
30Chronic mucocutaneous candidiasis (HP:0002728)3.16909622
31Recurrent cutaneous fungal infections (HP:0011370)3.16909622
32Chest pain (HP:0100749)3.14572642
33Vasculitis (HP:0002633)3.13028728
34Peritonitis (HP:0002586)3.09035638
35Amyloidosis (HP:0011034)3.02469544
36Cellulitis (HP:0100658)2.99758539
37Keratoconjunctivitis (HP:0001096)2.94530142
38Hemoptysis (HP:0002105)2.85221803
39Petechiae (HP:0000967)2.84349862
40Microcytic anemia (HP:0001935)2.68916013
41Gastrointestinal inflammation (HP:0004386)2.68550564
42Anorexia (HP:0002039)2.67441763
43Inflammation of the large intestine (HP:0002037)2.66269102
44Increased cerebral lipofuscin (HP:0011813)2.65011964
45Pulmonary infiltrates (HP:0002113)2.62252838
46Gingival bleeding (HP:0000225)2.61647995
47Epistaxis (HP:0000421)2.55652784
48Arterial thrombosis (HP:0004420)2.54078858
49Pulmonary embolism (HP:0002204)2.52876728
50Pustule (HP:0200039)2.49221455
51Loss of speech (HP:0002371)2.42258551
52Leukocytosis (HP:0001974)2.40863447
53Purpura (HP:0000979)2.40774812
54Increased serum ferritin (HP:0003281)2.38714585
55Abnormality of liposaccharide metabolism (HP:0010968)2.37692087
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.37692087
57Abnormality of glycolipid metabolism (HP:0010969)2.37692087
58Increased IgM level (HP:0003496)2.37011712
59Metaphyseal cupping (HP:0003021)2.29990861
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.28051012
61Acne (HP:0001061)2.28018782
62Panhypogammaglobulinemia (HP:0003139)2.26447564
63Hypergammaglobulinemia (HP:0010702)2.25364262
64Abnormality of the pleura (HP:0002103)2.23604992
65Sepsis (HP:0100806)2.22828630
66Dysostosis multiplex (HP:0000943)2.21778422
67Colitis (HP:0002583)2.15455193
68Abnormality of iron homeostasis (HP:0011031)2.15170770
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.14645168
70Osteomyelitis (HP:0002754)2.11774464
71Recurrent viral infections (HP:0004429)2.11250779
72Abnormality of the peritoneum (HP:0002585)2.10788319
73Hepatosplenomegaly (HP:0001433)2.07515548
74Granulocytopenia (HP:0001913)2.05472580
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05236350
76Abnormality of polysaccharide metabolism (HP:0011012)2.05236350
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05236350
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04954807
79Abnormality of the endocardium (HP:0004306)2.02206652
80Premature loss of primary teeth (HP:0006323)1.97997584
81Abnormality of the pericardium (HP:0001697)1.97473527
82Gangrene (HP:0100758)1.94617542
83Abnormal hemoglobin (HP:0011902)1.94389408
84Segmental peripheral demyelination/remyelination (HP:0003481)1.93414977
85Vertigo (HP:0002321)1.92724651
86Lymphopenia (HP:0001888)1.91549441
87Polycythemia (HP:0001901)1.91207686
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88667758
89Mucopolysacchariduria (HP:0008155)1.87394773
90Urinary glycosaminoglycan excretion (HP:0003541)1.87394773
91Hypermelanotic macule (HP:0001034)1.86841308
92Nasal polyposis (HP:0100582)1.84763755
93Cheilitis (HP:0100825)1.84649268
94Hypertensive crisis (HP:0100735)1.82194854
95Skin ulcer (HP:0200042)1.81491741
96Abnormality of T cells (HP:0002843)1.79799517
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79231358
98Toxemia of pregnancy (HP:0100603)1.79189255
99Keratitis (HP:0000491)1.78920513
100Abnormality of T cell physiology (HP:0011840)1.76925432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.25863318
2ERN13.40025960
3IRAK43.31387851
4MAP4K13.27419054
5TNK22.98831326
6MAP2K32.88288540
7BLK2.52733496
8EPHB12.49179108
9TRIB32.45174943
10GRK62.37239296
11TYK22.33475706
12CSK2.29809963
13FES2.24222436
14TAOK12.21210828
15MAP3K112.14924234
16PRPF4B2.03703211
17MAP3K31.80450000
18ZAP701.80053679
19SIK11.74914315
20BTK1.64067656
21MARK21.58480662
22SIK31.57422066
23HCK1.51406568
24PRKD21.44909556
25TBK11.35093218
26PTK61.34002392
27JAK31.33872748
28FGR1.29536946
29SMG11.27333403
30MAP3K11.26213405
31SYK1.20856961
32PKN21.20555734
33MAP3K131.18887178
34IKBKE1.18171535
35SIK21.10148178
36JAK21.09479444
37IRAK21.08890587
38TAOK21.05435152
39CSF1R1.05241105
40TXK1.05195386
41MAP3K71.04953278
42LYN1.04361999
43MARK31.01759219
44MAP3K141.00205015
45LRRK20.99223295
46KSR20.99175358
47CDK190.97801152
48LCK0.93051777
49PDPK10.90035538
50MATK0.89990058
51RPS6KC10.87148410
52RPS6KL10.87148410
53PDK10.86385690
54KIT0.84568318
55IRAK10.83799153
56TESK20.83285557
57MAP3K60.80275977
58ITK0.79622396
59RPS6KA60.76193017
60RPS6KA20.76179003
61MAP2K40.73986299
62IKBKB0.73497987
63STK110.72999417
64YES10.70561639
65MAP2K20.70358894
66JAK10.70295118
67HIPK20.69235221
68DYRK1B0.67058978
69CDC42BPA0.65175892
70MAPK70.62939143
71PTK2B0.62633581
72CAMKK10.61538329
73FYN0.61059821
74MAP2K60.60941775
75STK380.59775258
76TEC0.59713957
77MAPK120.58844547
78TAOK30.58776531
79IRAK30.54935786
80PRKG20.53618128
81RET0.51031851
82SGK30.50821195
83ICK0.50451736
84FGFR40.50442533
85DYRK30.47404325
86DAPK20.46127975
87MAPKAPK20.45317240
88PRKCZ0.45218384
89EPHA30.43856575
90PRKD10.38776099
91PRKCH0.37347855
92RPS6KA10.34270910
93MAP3K20.34035224
94CAMK40.32515963
95TGFBR20.31684476
96PRKCQ0.31388074
97MUSK0.31365734
98BMPR20.31112885
99KDR0.30647951
100BMX0.29388376

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.08046021
2Leishmaniasis_Homo sapiens_hsa051402.84288338
3Staphylococcus aureus infection_Homo sapiens_hsa051502.67263439
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.24827409
5B cell receptor signaling pathway_Homo sapiens_hsa046622.15678994
6Tuberculosis_Homo sapiens_hsa051522.09697157
7Acute myeloid leukemia_Homo sapiens_hsa052212.05196653
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01795143
9Other glycan degradation_Homo sapiens_hsa005112.01201824
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01088965
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96202912
12Graft-versus-host disease_Homo sapiens_hsa053321.88538379
13Allograft rejection_Homo sapiens_hsa053301.82505128
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82192481
15Malaria_Homo sapiens_hsa051441.81874425
16Autoimmune thyroid disease_Homo sapiens_hsa053201.72837939
17Chemokine signaling pathway_Homo sapiens_hsa040621.71376741
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60374943
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46120345
20Primary immunodeficiency_Homo sapiens_hsa053401.43592460
21Phagosome_Homo sapiens_hsa041451.42482415
22T cell receptor signaling pathway_Homo sapiens_hsa046601.41916973
23Measles_Homo sapiens_hsa051621.36890141
24Toxoplasmosis_Homo sapiens_hsa051451.36433962
25Hematopoietic cell lineage_Homo sapiens_hsa046401.35235604
26Type I diabetes mellitus_Homo sapiens_hsa049401.33697039
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.32584310
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28793253
29Non-small cell lung cancer_Homo sapiens_hsa052231.28209567
30Legionellosis_Homo sapiens_hsa051341.27864517
31Influenza A_Homo sapiens_hsa051641.27778661
32VEGF signaling pathway_Homo sapiens_hsa043701.26745636
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.26624590
34Notch signaling pathway_Homo sapiens_hsa043301.26456341
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.25116314
36Antigen processing and presentation_Homo sapiens_hsa046121.24754138
37African trypanosomiasis_Homo sapiens_hsa051431.23958540
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18868361
39TNF signaling pathway_Homo sapiens_hsa046681.17406236
40Viral myocarditis_Homo sapiens_hsa054161.16393179
41Hepatitis C_Homo sapiens_hsa051601.10442836
42Lysosome_Homo sapiens_hsa041421.10235138
43Platelet activation_Homo sapiens_hsa046111.09183801
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.09116702
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07823609
46Herpes simplex infection_Homo sapiens_hsa051681.07378567
47Salmonella infection_Homo sapiens_hsa051321.04189627
48Chronic myeloid leukemia_Homo sapiens_hsa052201.01629085
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.01364035
50Prolactin signaling pathway_Homo sapiens_hsa049170.98092022
51Hepatitis B_Homo sapiens_hsa051610.96635400
52Renal cell carcinoma_Homo sapiens_hsa052110.95479452
53Endocytosis_Homo sapiens_hsa041440.94834700
54Pertussis_Homo sapiens_hsa051330.94697874
55Pancreatic cancer_Homo sapiens_hsa052120.93123797
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91264760
57Shigellosis_Homo sapiens_hsa051310.91057551
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.89867728
59Rheumatoid arthritis_Homo sapiens_hsa053230.89841792
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.89565657
61Asthma_Homo sapiens_hsa053100.86593911
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84867984
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84191315
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.82916634
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.81489773
66Endometrial cancer_Homo sapiens_hsa052130.80887747
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75512625
68Choline metabolism in cancer_Homo sapiens_hsa052310.75000605
69GnRH signaling pathway_Homo sapiens_hsa049120.72458399
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.70665174
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70577595
72mTOR signaling pathway_Homo sapiens_hsa041500.70207152
73Apoptosis_Homo sapiens_hsa042100.69184184
74Insulin resistance_Homo sapiens_hsa049310.68348185
75Regulation of autophagy_Homo sapiens_hsa041400.68035034
76Amoebiasis_Homo sapiens_hsa051460.65166441
77Collecting duct acid secretion_Homo sapiens_hsa049660.62081653
78FoxO signaling pathway_Homo sapiens_hsa040680.61709537
79Insulin signaling pathway_Homo sapiens_hsa049100.61234034
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60850567
81Inositol phosphate metabolism_Homo sapiens_hsa005620.60115334
82MAPK signaling pathway_Homo sapiens_hsa040100.59490158
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59415663
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58789520
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57624556
86Rap1 signaling pathway_Homo sapiens_hsa040150.57423151
87Type II diabetes mellitus_Homo sapiens_hsa049300.56985934
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56235124
89Estrogen signaling pathway_Homo sapiens_hsa049150.56235123
90ErbB signaling pathway_Homo sapiens_hsa040120.53410834
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49673936
92Epstein-Barr virus infection_Homo sapiens_hsa051690.49590106
93HIF-1 signaling pathway_Homo sapiens_hsa040660.49092737
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49014628
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48679140
96Colorectal cancer_Homo sapiens_hsa052100.46093186
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45937225
98HTLV-I infection_Homo sapiens_hsa051660.42728693
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39985154
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37961190

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