ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.68721876
2	replication fork processing (GO:0031297)	4.18075093
3	DNA catabolic process, exonucleolytic (GO:0000738)	4.14184162
4	cullin deneddylation (GO:0010388)	4.08205582
5	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	4.04772526
6	regulation of meiosis I (GO:0060631)	3.96457777
7	protein deneddylation (GO:0000338)	3.96383302
8	postreplication repair (GO:0006301)	3.92379524
9	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.85388152
10	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.85388152
11	DNA strand renaturation (GO:0000733)	3.82865190
12	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.79276248
13	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.79276248
14	isotype switching (GO:0045190)	3.79276248
15	prenylation (GO:0097354)	3.70916655
16	protein prenylation (GO:0018342)	3.70916655
17	tryptophan metabolic process (GO:0006568)	3.68591831
18	ribosome assembly (GO:0042255)	3.65166432
19	double-strand break repair via homologous recombination (GO:0000724)	3.64576173
20	recombinational repair (GO:0000725)	3.63759414
21	protein K11-linked deubiquitination (GO:0035871)	3.58677349
22	lysine metabolic process (GO:0006553)	3.49875017
23	lysine catabolic process (GO:0006554)	3.49875017
24	DNA deamination (GO:0045006)	3.48445417
25	indolalkylamine metabolic process (GO:0006586)	3.41924439
26	regulation of DNA endoreduplication (GO:0032875)	3.41888340
27	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.35353991
28	chromatin remodeling at centromere (GO:0031055)	3.33632477
29	regulation of helicase activity (GO:0051095)	3.31029683
30	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.23997228
31	adenosine metabolic process (GO:0046085)	3.20863766
32	response to X-ray (GO:0010165)	3.20728562
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.18268828
34	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.17330761
35	regulation of mitotic spindle checkpoint (GO:1903504)	3.17330761
36	aspartate family amino acid catabolic process (GO:0009068)	3.14008367
37	CENP-A containing nucleosome assembly (GO:0034080)	3.12879131
38	tryptophan catabolic process (GO:0006569)	3.12363638
39	indole-containing compound catabolic process (GO:0042436)	3.12363638
40	indolalkylamine catabolic process (GO:0046218)	3.12363638
41	regulation of cilium movement (GO:0003352)	3.10933771
42	piRNA metabolic process (GO:0034587)	3.08992139
43	pseudouridine synthesis (GO:0001522)	3.08899764
44	DNA demethylation (GO:0080111)	3.06372476
45	fucose catabolic process (GO:0019317)	3.06085965
46	L-fucose metabolic process (GO:0042354)	3.06085965
47	L-fucose catabolic process (GO:0042355)	3.06085965
48	kynurenine metabolic process (GO:0070189)	3.03455315
49	respiratory chain complex IV assembly (GO:0008535)	3.03237428
50	branched-chain amino acid catabolic process (GO:0009083)	3.02663851
51	somatic diversification of immunoglobulins (GO:0016445)	2.98910502
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.96941620
53	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.96073822
54	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.96073822
55	regulation of translation, ncRNA-mediated (GO:0045974)	2.96073822
56	negative regulation of DNA recombination (GO:0045910)	2.95171082
57	histone H2A acetylation (GO:0043968)	2.94883503
58	response to pheromone (GO:0019236)	2.88370552
59	acrosome assembly (GO:0001675)	2.87066187
60	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.87007238
61	synapsis (GO:0007129)	2.85664214
62	proteasome assembly (GO:0043248)	2.82003721
63	intestinal epithelial cell development (GO:0060576)	2.81373879
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.80867557
65	tRNA processing (GO:0008033)	2.80757990
66	protein heterotetramerization (GO:0051290)	2.80476133
67	lactate metabolic process (GO:0006089)	2.80343288
68	reciprocal DNA recombination (GO:0035825)	2.80125397
69	reciprocal meiotic recombination (GO:0007131)	2.80125397
70	ether lipid metabolic process (GO:0046485)	2.79185572
71	DNA replication-dependent nucleosome assembly (GO:0006335)	2.79108603
72	DNA replication-dependent nucleosome organization (GO:0034723)	2.79108603
73	translesion synthesis (GO:0019985)	2.75794664
74	photoreceptor cell maintenance (GO:0045494)	2.74936002
75	histone exchange (GO:0043486)	2.74881242
76	resolution of meiotic recombination intermediates (GO:0000712)	2.72470238
77	cytochrome complex assembly (GO:0017004)	2.72196066
78	rRNA methylation (GO:0031167)	2.71857254
79	protein polyglutamylation (GO:0018095)	2.71372476
80	protein K6-linked ubiquitination (GO:0085020)	2.69774317
81	double-strand break repair (GO:0006302)	2.69337836
82	protein-cofactor linkage (GO:0018065)	2.69216752
83	histone mRNA catabolic process (GO:0071044)	2.66703209
84	protein K11-linked ubiquitination (GO:0070979)	2.66243612
85	purine nucleobase biosynthetic process (GO:0009113)	2.64783168
86	ncRNA catabolic process (GO:0034661)	2.62621437
87	RNA phosphodiester bond hydrolysis (GO:0090501)	2.61449514
88	platelet dense granule organization (GO:0060155)	2.60797884
89	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.59707971
90	magnesium ion transport (GO:0015693)	2.59428678
91	histone mRNA metabolic process (GO:0008334)	2.58242618
92	maturation of 5.8S rRNA (GO:0000460)	2.56532822
93	mitochondrial respiratory chain complex assembly (GO:0033108)	2.56487497
94	nucleobase biosynthetic process (GO:0046112)	2.55816110
95	rRNA modification (GO:0000154)	2.55233404
96	centriole replication (GO:0007099)	2.54849407
97	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.54474657
98	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.54474657
99	neural tube formation (GO:0001841)	2.54343618
100	DNA recombination (GO:0006310)	2.54325662

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54709548
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.36969150
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.31586694
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.91549226
5	VDR_22108803_ChIP-Seq_LS180_Human	2.80645704
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.74705951
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.46426383
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.43965753
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.43620698
10	E2F7_22180533_ChIP-Seq_HELA_Human	2.35684612
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32375531
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.28189072
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26336265
14	FUS_26573619_Chip-Seq_HEK293_Human	2.19259936
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.15577553
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13783049
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11811653
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.06721891
19	EWS_26573619_Chip-Seq_HEK293_Human	2.05528329
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.05318081
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.04642928
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.00678248
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98602232
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.91498835
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85507028
26	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84791811
27	P300_19829295_ChIP-Seq_ESCs_Human	1.79352427
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78593863
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.77809314
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.77428943
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.72123213
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.70454974
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.69810591
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.63654239
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.59543434
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.57126928
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.57078834
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.57005645
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55075685
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.51407563
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51290418
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49070337
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.46185006
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45358165
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.42149546
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41010130
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40725864
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40673461
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.40332581
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40332581
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.39315440
52	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.37598188
53	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.35340017
54	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.27708866
55	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.26352679
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.25784375
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24990134
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22114663
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22114663
60	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.20156569
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19400312
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18192212
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.18165205
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15174007
65	CDX2_22108803_ChIP-Seq_LS180_Human	1.14992412
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14139252
67	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13864795
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13687304
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13447562
70	AR_25329375_ChIP-Seq_VCAP_Human	1.13204302
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13110215
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13012591
73	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11036302
74	TCF4_23295773_ChIP-Seq_U87_Human	1.10416633
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10238294
76	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09986796
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09940048
78	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.08903841
79	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08733103
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06181586
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06167182
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05592892
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05476993
84	STAT3_23295773_ChIP-Seq_U87_Human	1.04764948
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04273629
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02271309
87	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01983458
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01882733
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01882733
90	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01680889
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01408143
92	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01167765
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.99724765
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99392641
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99331847
96	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99083378
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98747789
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.97872675
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96512196
100	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96240199

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.41391352
2	MP0008058_abnormal_DNA_repair	3.55806671
3	MP0008057_abnormal_DNA_replication	3.26146954
4	MP0006054_spinal_hemorrhage	2.75914955
5	MP0000569_abnormal_digit_pigmentation	2.74612379
6	MP0002876_abnormal_thyroid_physiology	2.60729988
7	MP0010094_abnormal_chromosome_stability	2.47992598
8	MP0003195_calcinosis	2.36661196
9	MP0003693_abnormal_embryo_hatching	2.31566538
10	MP0005084_abnormal_gallbladder_morpholo	2.27478684
11	MP0001986_abnormal_taste_sensitivity	2.22315640
12	MP0002736_abnormal_nociception_after	2.15786102
13	MP0003567_abnormal_fetal_cardiomyocyte	2.09195329
14	MP0002254_reproductive_system_inflammat	2.07321773
15	MP0003787_abnormal_imprinting	1.97819013
16	MP0002102_abnormal_ear_morphology	1.96123486
17	MP0008007_abnormal_cellular_replicative	1.95569552
18	MP0001968_abnormal_touch/_nociception	1.86084502
19	MP0000427_abnormal_hair_cycle	1.84940288
20	MP0003718_maternal_effect	1.83196272
21	MP0005551_abnormal_eye_electrophysiolog	1.81154574
22	MP0008872_abnormal_physiological_respon	1.79741190
23	MP0003786_premature_aging	1.78048931
24	MP0005310_abnormal_salivary_gland	1.61185254
25	MP0002163_abnormal_gland_morphology	1.58714470
26	MP0005646_abnormal_pituitary_gland	1.57970623
27	MP0003806_abnormal_nucleotide_metabolis	1.56769423
28	MP0000647_abnormal_sebaceous_gland	1.52986594
29	MP0000516_abnormal_urinary_system	1.52273524
30	MP0005367_renal/urinary_system_phenotyp	1.52273524
31	MP0004215_abnormal_myocardial_fiber	1.46535911
32	MP0000383_abnormal_hair_follicle	1.45119339
33	MP0001919_abnormal_reproductive_system	1.45059684
34	MP0009697_abnormal_copulation	1.42018431
35	MP0010678_abnormal_skin_adnexa	1.41051104
36	MP0010307_abnormal_tumor_latency	1.39810463
37	MP0004957_abnormal_blastocyst_morpholog	1.39568514
38	MP0005389_reproductive_system_phenotype	1.39071640
39	MP0001764_abnormal_homeostasis	1.38687054
40	MP0003121_genomic_imprinting	1.36455024
41	MP0010352_gastrointestinal_tract_polyps	1.34704635
42	MP0006072_abnormal_retinal_apoptosis	1.30056329
43	MP0009780_abnormal_chondrocyte_physiolo	1.29352669
44	MP0004264_abnormal_extraembryonic_tissu	1.26876253
45	MP0008775_abnormal_heart_ventricle	1.23926745
46	MP0005075_abnormal_melanosome_morpholog	1.22579800
47	MP0004147_increased_porphyrin_level	1.20746972
48	MP0005379_endocrine/exocrine_gland_phen	1.20703763
49	MP0003880_abnormal_central_pattern	1.18607109
50	MP0006035_abnormal_mitochondrial_morpho	1.18101230
51	MP0000372_irregular_coat_pigmentation	1.16730986
52	MP0003077_abnormal_cell_cycle	1.14035028
53	MP0004043_abnormal_pH_regulation	1.12586798
54	MP0008995_early_reproductive_senescence	1.10153564
55	MP0003937_abnormal_limbs/digits/tail_de	1.07260428
56	MP0005253_abnormal_eye_physiology	1.05862323
57	MP0001929_abnormal_gametogenesis	1.04660608
58	MP0003111_abnormal_nucleus_morphology	1.04110954
59	MP0003950_abnormal_plasma_membrane	1.03641380
60	MP0001119_abnormal_female_reproductive	1.01680290
61	MP0000631_abnormal_neuroendocrine_gland	1.00844405
62	MP0005410_abnormal_fertilization	0.97610954
63	MP0005174_abnormal_tail_pigmentation	0.95655847
64	MP0002277_abnormal_respiratory_mucosa	0.94619653
65	MP0002234_abnormal_pharynx_morphology	0.94095842
66	MP0001177_atelectasis	0.93264087
67	MP0003943_abnormal_hepatobiliary_system	0.92195327
68	MP0008875_abnormal_xenobiotic_pharmacok	0.90870584
69	MP0002160_abnormal_reproductive_system	0.89021925
70	MP0002210_abnormal_sex_determination	0.88621370
71	MP0005395_other_phenotype	0.87719219
72	MP0010234_abnormal_vibrissa_follicle	0.87235432
73	MP0000653_abnormal_sex_gland	0.86811337
74	MP0002098_abnormal_vibrissa_morphology	0.86462997
75	MP0005671_abnormal_response_to	0.85918746
76	MP0002938_white_spotting	0.85711275
77	MP0003890_abnormal_embryonic-extraembry	0.83619716
78	MP0009703_decreased_birth_body	0.83533690
79	MP0001346_abnormal_lacrimal_gland	0.79519136
80	MP0005332_abnormal_amino_acid	0.77040938
81	MP0002233_abnormal_nose_morphology	0.75615469
82	MP0001145_abnormal_male_reproductive	0.73240567
83	MP0003252_abnormal_bile_duct	0.73215133
84	MP0001984_abnormal_olfaction	0.73075859
85	MP0005266_abnormal_metabolism	0.71823736
86	MP0000538_abnormal_urinary_bladder	0.69566017
87	MP0003868_abnormal_feces_composition	0.67467749
88	MP0008789_abnormal_olfactory_epithelium	0.67407142
89	MP0003698_abnormal_male_reproductive	0.66778856
90	MP0002095_abnormal_skin_pigmentation	0.64486453
91	MP0003941_abnormal_skin_development	0.64454535
92	MP0005636_abnormal_mineral_homeostasis	0.63903023
93	MP0004019_abnormal_vitamin_homeostasis	0.63303226
94	MP0002138_abnormal_hepatobiliary_system	0.63083838
95	MP0001697_abnormal_embryo_size	0.63020803
96	MP0009765_abnormal_xenobiotic_induced	0.62974566
97	MP0001727_abnormal_embryo_implantation	0.62750584
98	MP0003119_abnormal_digestive_system	0.62254433
99	MP0001501_abnormal_sleep_pattern	0.61882072
100	MP0003936_abnormal_reproductive_system	0.60707868

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.71185796
2	Volvulus (HP:0002580)	3.69678224
3	Colon cancer (HP:0003003)	3.46314268
4	True hermaphroditism (HP:0010459)	3.12520810
5	Pancreatic fibrosis (HP:0100732)	3.03592583
6	Autoimmune hemolytic anemia (HP:0001890)	3.03134982
7	Stomach cancer (HP:0012126)	2.99445083
8	Abnormal biliary tract physiology (HP:0012439)	2.83495279
9	Bile duct proliferation (HP:0001408)	2.83495279
10	Abnormality of B cell number (HP:0010975)	2.81828105
11	Abnormality of chromosome stability (HP:0003220)	2.80284905
12	Abnormality of the ileum (HP:0001549)	2.76387838
13	Abnormality of midbrain morphology (HP:0002418)	2.73636886
14	Molar tooth sign on MRI (HP:0002419)	2.73636886
15	Progressive inability to walk (HP:0002505)	2.63440959
16	Congenital stationary night blindness (HP:0007642)	2.59921043
17	Glioma (HP:0009733)	2.57323612
18	Ependymoma (HP:0002888)	2.53459492
19	Medial flaring of the eyebrow (HP:0010747)	2.47438596
20	Meckel diverticulum (HP:0002245)	2.46477403
21	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.45588818
22	B lymphocytopenia (HP:0010976)	2.43355401
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.43243278
24	Absent/shortened dynein arms (HP:0200106)	2.43243278
25	Hyperventilation (HP:0002883)	2.43126027
26	Astrocytoma (HP:0009592)	2.41691978
27	Abnormality of the astrocytes (HP:0100707)	2.41691978
28	Abnormality of the preputium (HP:0100587)	2.39244883
29	Abolished electroretinogram (ERG) (HP:0000550)	2.37528557
30	Abnormality of T cell number (HP:0011839)	2.35125969
31	Autoimmune thrombocytopenia (HP:0001973)	2.34887894
32	Thyroiditis (HP:0100646)	2.33771963
33	Chronic hepatic failure (HP:0100626)	2.33689343
34	Hypothermia (HP:0002045)	2.32126395
35	Intestinal atresia (HP:0011100)	2.31400483
36	Abnormality of the renal cortex (HP:0011035)	2.30556346
37	Nephrogenic diabetes insipidus (HP:0009806)	2.29350052
38	Nephronophthisis (HP:0000090)	2.20266397
39	Pendular nystagmus (HP:0012043)	2.17925231
40	Abnormality of the renal medulla (HP:0100957)	2.16622969
41	Chromsome breakage (HP:0040012)	2.13134286
42	Tubular atrophy (HP:0000092)	2.13065541
43	Stenosis of the external auditory canal (HP:0000402)	2.06810397
44	Aplasia/hypoplasia of the uterus (HP:0008684)	2.06526747
45	Severe combined immunodeficiency (HP:0004430)	2.06205772
46	Polydipsia (HP:0001959)	2.03918295
47	Abnormal drinking behavior (HP:0030082)	2.03918295
48	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.99150420
49	Nephroblastoma (Wilms tumor) (HP:0002667)	1.98864156
50	Hypoplasia of the uterus (HP:0000013)	1.98841048
51	Medulloblastoma (HP:0002885)	1.97810211
52	Hepatocellular necrosis (HP:0001404)	1.97214080
53	Thyroid-stimulating hormone excess (HP:0002925)	1.95812147
54	Sloping forehead (HP:0000340)	1.94993496
55	Increased CSF lactate (HP:0002490)	1.94730380
56	Biliary tract neoplasm (HP:0100574)	1.94656595
57	Abnormal lung lobation (HP:0002101)	1.94035880
58	Eosinophilia (HP:0001880)	1.93397691
59	Cystic liver disease (HP:0006706)	1.92896422
60	Abnormal biliary tract morphology (HP:0012440)	1.92384513
61	Embryonal renal neoplasm (HP:0011794)	1.91155619
62	Clubbing of toes (HP:0100760)	1.89766869
63	3-Methylglutaconic aciduria (HP:0003535)	1.89669329
64	Sclerocornea (HP:0000647)	1.88822460
65	Male pseudohermaphroditism (HP:0000037)	1.88314242
66	Neoplasm of the adrenal cortex (HP:0100641)	1.87113803
67	Congenital primary aphakia (HP:0007707)	1.85924340
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84890372
69	Abnormality of eosinophils (HP:0001879)	1.84506469
70	Supernumerary spleens (HP:0009799)	1.81293835
71	Genital tract atresia (HP:0001827)	1.79432062
72	Rhabdomyosarcoma (HP:0002859)	1.78352731
73	Pancreatic islet-cell hyperplasia (HP:0004510)	1.77979800
74	Inability to walk (HP:0002540)	1.77616125
75	Type II lissencephaly (HP:0007260)	1.77558276
76	Vaginal atresia (HP:0000148)	1.77504175
77	Increased serum lactate (HP:0002151)	1.77407992
78	Abnormality of the pons (HP:0007361)	1.76467274
79	Ketoacidosis (HP:0001993)	1.73995104
80	T lymphocytopenia (HP:0005403)	1.72314158
81	Hepatic necrosis (HP:0002605)	1.71112979
82	Gait imbalance (HP:0002141)	1.70826325
83	Methylmalonic acidemia (HP:0002912)	1.70795388
84	Duodenal stenosis (HP:0100867)	1.70067897
85	Small intestinal stenosis (HP:0012848)	1.70067897
86	Ketosis (HP:0001946)	1.69373326
87	Cupped ear (HP:0000378)	1.69092149
88	Delayed CNS myelination (HP:0002188)	1.69079871
89	Breast carcinoma (HP:0003002)	1.68843265
90	Lipid accumulation in hepatocytes (HP:0006561)	1.68812409
91	Polyuria (HP:0000103)	1.67864687
92	Mitochondrial inheritance (HP:0001427)	1.67747518
93	Combined immunodeficiency (HP:0005387)	1.65928153
94	Congenital, generalized hypertrichosis (HP:0004540)	1.65814482
95	Small hand (HP:0200055)	1.65321000
96	Congenital hepatic fibrosis (HP:0002612)	1.64831913
97	Neoplasm of the small intestine (HP:0100833)	1.64531852
98	Neoplasm of the adrenal gland (HP:0100631)	1.63459468
99	Lissencephaly (HP:0001339)	1.63303287
100	Large for gestational age (HP:0001520)	1.62969589

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	3.91734655
2	FRK	3.74031071
3	TRIM28	3.50058090
4	TAOK3	3.32747259
5	NUAK1	3.01457303
6	TNIK	2.80383175
7	MST4	2.41289715
8	BRSK2	2.39399528
9	BCR	2.31325964
10	ACVR1B	2.30840702
11	WNK3	2.24398668
12	BMPR1B	2.18303165
13	ADRBK2	2.06633900
14	STK39	1.86700022
15	ERBB3	1.81336029
16	ZAK	1.79551706
17	STK38L	1.73765208
18	BUB1	1.71543087
19	WNK4	1.69236412
20	INSRR	1.64723092
21	OXSR1	1.61502678
22	MAP4K2	1.61245582
23	PNCK	1.58927749
24	WEE1	1.56953676
25	SRPK1	1.51513619
26	GRK1	1.50256110
27	MAP3K12	1.45464714
28	PBK	1.45055532
29	TXK	1.41186621
30	TSSK6	1.38038290
31	MAP3K4	1.37694863
32	MKNK2	1.37676660
33	EIF2AK1	1.30582546
34	PLK3	1.28002840
35	PLK4	1.25440564
36	STK3	1.24678171
37	BRD4	1.17450733
38	NLK	1.16136342
39	STK16	1.15170355
40	EIF2AK2	1.09322614
41	PLK2	1.06847695
42	LATS1	1.05132484
43	TTK	1.04432374
44	MAP3K14	0.99894688
45	ERBB4	0.99833877
46	NEK1	0.97236395
47	PINK1	0.95564117
48	TEC	0.90527687
49	CAMKK2	0.85915772
50	TGFBR1	0.80897154
51	VRK2	0.80783265
52	VRK1	0.78495730
53	TLK1	0.77601771
54	CSNK1G1	0.73344518
55	IKBKB	0.72062794
56	MKNK1	0.69281067
57	BCKDK	0.68724123
58	PLK1	0.67512170
59	ATR	0.66159950
60	MAPK13	0.66068357
61	ATM	0.62799245
62	ADRBK1	0.60477804
63	PRKCE	0.58258686
64	TRPM7	0.58225375
65	SIK3	0.57111916
66	AKT3	0.52156696
67	MAP2K6	0.51285089
68	PRKCQ	0.50935222
69	CSNK1A1L	0.50917517
70	TAF1	0.50717861
71	FGFR1	0.50512548
72	CSNK1G3	0.50503947
73	MAP2K7	0.49744837
74	CASK	0.48039649
75	IKBKE	0.47016396
76	ABL1	0.44959795
77	MUSK	0.44812015
78	PAK3	0.43577428
79	PRKCI	0.43098899
80	PIK3CA	0.39342342
81	CDC7	0.38752479
82	CSNK1G2	0.38672396
83	CHUK	0.38177801
84	AURKB	0.37362189
85	CSNK1A1	0.35468428
86	ITK	0.34670060
87	PRKCG	0.33344979
88	STK10	0.31492110
89	FER	0.29568363
90	PDK2	0.28508261
91	IGF1R	0.26841158
92	BRSK1	0.24860436
93	CCNB1	0.24691239
94	FGR	0.24281902
95	PRKACB	0.23941345
96	MELK	0.21821309
97	CHEK1	0.21660202
98	YES1	0.21648933
99	BMPR2	0.20921389
100	CSNK1D	0.20903670

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.39284892
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.31810580
3	Proteasome_Homo sapiens_hsa03050	3.15805261
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.14616649
5	Protein export_Homo sapiens_hsa03060	2.90349054
6	Mismatch repair_Homo sapiens_hsa03430	2.86335472
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.61482605
8	Basal transcription factors_Homo sapiens_hsa03022	2.60638742
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.16506165
10	Propanoate metabolism_Homo sapiens_hsa00640	2.15686755
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13958287
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07711742
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.05823922
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.05301457
15	Selenocompound metabolism_Homo sapiens_hsa00450	2.03545000
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.02299378
17	RNA degradation_Homo sapiens_hsa03018	1.95918545
18	Butanoate metabolism_Homo sapiens_hsa00650	1.78858533
19	Phototransduction_Homo sapiens_hsa04744	1.76684456
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.69212009
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.67788164
22	RNA polymerase_Homo sapiens_hsa03020	1.66454636
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.65727415
24	One carbon pool by folate_Homo sapiens_hsa00670	1.60104106
25	DNA replication_Homo sapiens_hsa03030	1.57423362
26	RNA transport_Homo sapiens_hsa03013	1.53977245
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.51313776
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42418614
29	Caffeine metabolism_Homo sapiens_hsa00232	1.35854953
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.26904132
31	Sulfur metabolism_Homo sapiens_hsa00920	1.26883023
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.21784348
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.19328745
34	Regulation of autophagy_Homo sapiens_hsa04140	1.16403194
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.16375844
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10947500
37	Oxidative phosphorylation_Homo sapiens_hsa00190	1.06119983
38	Spliceosome_Homo sapiens_hsa03040	1.04436537
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.02883397
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.02177615
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00970443
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00000235
43	Purine metabolism_Homo sapiens_hsa00230	0.98908210
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98589367
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96278987
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95893160
47	Base excision repair_Homo sapiens_hsa03410	0.93832157
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93354484
49	p53 signaling pathway_Homo sapiens_hsa04115	0.92629563
50	Cell cycle_Homo sapiens_hsa04110	0.87879408
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87532824
52	Fatty acid elongation_Homo sapiens_hsa00062	0.86787933
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85872230
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84602655
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82052803
56	Parkinsons disease_Homo sapiens_hsa05012	0.81071769
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80448923
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74771654
59	Peroxisome_Homo sapiens_hsa04146	0.74202037
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73709939
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72883670
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68544252
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68388225
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67753735
65	Retinol metabolism_Homo sapiens_hsa00830	0.67650896
66	Glutathione metabolism_Homo sapiens_hsa00480	0.66810024
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56853661
68	Circadian rhythm_Homo sapiens_hsa04710	0.56842837
69	Olfactory transduction_Homo sapiens_hsa04740	0.56783657
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56353343
71	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.56166312
72	Fatty acid degradation_Homo sapiens_hsa00071	0.55963087
73	Metabolic pathways_Homo sapiens_hsa01100	0.55832693
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.55549106
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48831219
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.47653734
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44920900
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43995709
79	Taste transduction_Homo sapiens_hsa04742	0.43969830
80	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.43091645
81	Mineral absorption_Homo sapiens_hsa04978	0.41784018
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41670331
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41084932
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39527418
85	Huntingtons disease_Homo sapiens_hsa05016	0.39424945
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38313071
87	Allograft rejection_Homo sapiens_hsa05330	0.37988307
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.37337424
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36752038
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36032760
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.33812377
92	Type I diabetes mellitus_Homo sapiens_hsa04940	0.33279666
93	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.31639038
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31442231
95	Oocyte meiosis_Homo sapiens_hsa04114	0.30440200
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29417537
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.28420634
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.24835717
99	Measles_Homo sapiens_hsa05162	0.24687391
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.24558911

ZNF468

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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