ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.87338397
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.00243946
3	nonmotile primary cilium assembly (GO:0035058)	3.91457714
4	indolalkylamine metabolic process (GO:0006586)	3.70525270
5	pyrimidine nucleobase catabolic process (GO:0006208)	3.67727455
6	neural tube formation (GO:0001841)	3.66274923
7	gamma-aminobutyric acid transport (GO:0015812)	3.61563878
8	L-fucose catabolic process (GO:0042355)	3.56530532
9	fucose catabolic process (GO:0019317)	3.56530532
10	L-fucose metabolic process (GO:0042354)	3.56530532
11	indole-containing compound catabolic process (GO:0042436)	3.48226406
12	indolalkylamine catabolic process (GO:0046218)	3.48226406
13	tryptophan catabolic process (GO:0006569)	3.48226406
14	retinal cone cell development (GO:0046549)	3.46407105
15	reflex (GO:0060004)	3.43640920
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.40878115
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.32568973
18	detection of light stimulus involved in visual perception (GO:0050908)	3.32568973
19	kynurenine metabolic process (GO:0070189)	3.31042349
20	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.22240547
21	regulation of translation, ncRNA-mediated (GO:0045974)	3.22240547
22	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.22240547
23	postsynaptic membrane organization (GO:0001941)	3.16674089
24	response to pheromone (GO:0019236)	3.14015342
25	photoreceptor cell maintenance (GO:0045494)	3.13867807
26	presynaptic membrane assembly (GO:0097105)	3.13805568
27	kidney morphogenesis (GO:0060993)	3.11037891
28	epithelial cilium movement (GO:0003351)	3.10998610
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.10053171
30	indole-containing compound metabolic process (GO:0042430)	3.06805142
31	behavioral response to ethanol (GO:0048149)	3.05815105
32	transmission of nerve impulse (GO:0019226)	3.03566068
33	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.02358219
34	nucleobase catabolic process (GO:0046113)	3.00749384
35	protein polyglutamylation (GO:0018095)	2.95970228
36	cellular ketone body metabolic process (GO:0046950)	2.94328957
37	tryptophan metabolic process (GO:0006568)	2.93525394
38	presynaptic membrane organization (GO:0097090)	2.93290306
39	cilium morphogenesis (GO:0060271)	2.93221380
40	cilium organization (GO:0044782)	2.93083856
41	axoneme assembly (GO:0035082)	2.92291428
42	primary amino compound metabolic process (GO:1901160)	2.92122281
43	neuronal action potential (GO:0019228)	2.92086409
44	inner ear receptor stereocilium organization (GO:0060122)	2.91796677
45	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.90639241
46	sulfation (GO:0051923)	2.90570370
47	cilium assembly (GO:0042384)	2.87955005
48	serotonin metabolic process (GO:0042428)	2.87144395
49	regulation of action potential (GO:0098900)	2.83536157
50	protein localization to cilium (GO:0061512)	2.82841814
51	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.79977004
52	regulation of cilium movement (GO:0003352)	2.79736971
53	piRNA metabolic process (GO:0034587)	2.79698634
54	negative regulation of telomere maintenance (GO:0032205)	2.79553655
55	regulation of neurotransmitter uptake (GO:0051580)	2.78240055
56	cilium movement (GO:0003341)	2.78097578
57	protein localization to synapse (GO:0035418)	2.69476443
58	regulation of hippo signaling (GO:0035330)	2.68920024
59	auditory receptor cell stereocilium organization (GO:0060088)	2.68234811
60	photoreceptor cell development (GO:0042461)	2.68040229
61	startle response (GO:0001964)	2.67900411
62	ketone body metabolic process (GO:1902224)	2.66453737
63	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.62924037
64	cAMP catabolic process (GO:0006198)	2.61576708
65	cellular biogenic amine catabolic process (GO:0042402)	2.59596036
66	amine catabolic process (GO:0009310)	2.59596036
67	negative regulation of mast cell activation (GO:0033004)	2.58914187
68	platelet dense granule organization (GO:0060155)	2.58194456
69	dendritic spine morphogenesis (GO:0060997)	2.58023435
70	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.56891398
71	regulation of posttranscriptional gene silencing (GO:0060147)	2.56710914
72	regulation of gene silencing by miRNA (GO:0060964)	2.56710914
73	regulation of gene silencing by RNA (GO:0060966)	2.56710914
74	neuron cell-cell adhesion (GO:0007158)	2.55753617
75	intraciliary transport (GO:0042073)	2.55310506
76	membrane depolarization during action potential (GO:0086010)	2.53798043
77	protein K11-linked deubiquitination (GO:0035871)	2.52771615
78	rhodopsin mediated signaling pathway (GO:0016056)	2.50315592
79	auditory behavior (GO:0031223)	2.49860469
80	somite development (GO:0061053)	2.49328527
81	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.48973287
82	neuronal action potential propagation (GO:0019227)	2.47556532
83	negative regulation of systemic arterial blood pressure (GO:0003085)	2.47541509
84	regulation of collateral sprouting (GO:0048670)	2.45881298
85	regulation of telomere maintenance (GO:0032204)	2.44236044
86	synapse assembly (GO:0007416)	2.43766819
87	cyclic nucleotide catabolic process (GO:0009214)	2.42412657
88	spinal cord motor neuron differentiation (GO:0021522)	2.41799223
89	synaptic transmission, cholinergic (GO:0007271)	2.41448587
90	retinal ganglion cell axon guidance (GO:0031290)	2.41443941
91	righting reflex (GO:0060013)	2.41170466
92	adaptation of signaling pathway (GO:0023058)	2.40830983
93	cornea development in camera-type eye (GO:0061303)	2.39308470
94	hindbrain development (GO:0030902)	2.39069828
95	negative regulation of response to food (GO:0032096)	2.38544360
96	negative regulation of appetite (GO:0032099)	2.38544360
97	tachykinin receptor signaling pathway (GO:0007217)	2.37278597
98	DNA methylation involved in gamete generation (GO:0043046)	2.36836569
99	cellular component assembly involved in morphogenesis (GO:0010927)	2.36800588
100	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.36639297

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.73112742
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.47731326
3	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.28582926
4	VDR_22108803_ChIP-Seq_LS180_Human	2.89606039
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.78006978
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.72687177
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71026111
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42361120
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.38375680
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37977733
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.36201425
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19376797
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.16432079
14	P300_19829295_ChIP-Seq_ESCs_Human	2.16143174
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.03682752
16	FUS_26573619_Chip-Seq_HEK293_Human	1.99265885
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.90105419
18	EWS_26573619_Chip-Seq_HEK293_Human	1.89831773
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85378912
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.83691965
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.81544333
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77900416
23	STAT3_23295773_ChIP-Seq_U87_Human	1.74303492
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.74052057
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.73867169
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.73081671
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72466314
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.70436150
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69094646
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.65323261
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63049455
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63049455
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.61992671
34	TCF4_23295773_ChIP-Seq_U87_Human	1.56597101
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.56400092
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56400092
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.56326444
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55613052
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54778678
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.54472057
41	* BCAT_22108803_ChIP-Seq_LS180_Human	1.54123395
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.51445730
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47432812
44	AR_25329375_ChIP-Seq_VCAP_Human	1.46653036
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42826924
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41872973
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41564085
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40432590
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39514040
50	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39325220
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38565183
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.34922689
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33805868
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33552899
55	* TCF4_22108803_ChIP-Seq_LS180_Human	1.32164944
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32092407
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32080730
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31763670
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28388822
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26781507
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24691247
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24688933
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.24649486
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23049304
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22168237
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.20944864
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20944469
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20591495
69	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.20394265
70	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.20394265
71	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20192951
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19175192
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14485838
74	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14199189
75	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10649230
76	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10640164
77	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10453766
78	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10384983
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10220708
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09906149
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09306561
82	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08608116
83	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07491843
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07311570
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06943208
86	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06595175
87	JUN_21703547_ChIP-Seq_K562_Human	1.05768254
88	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05199661
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04769280
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04464450
91	CDX2_22108803_ChIP-Seq_LS180_Human	1.03576235
92	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.03499602
93	TP53_16413492_ChIP-PET_HCT116_Human	1.03035351
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02576687
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02372549
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02372549
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01803494
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00966914
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00589127
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00409511

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.51779451
2	MP0002102_abnormal_ear_morphology	2.74281667
3	MP0005551_abnormal_eye_electrophysiolog	2.60996874
4	MP0003880_abnormal_central_pattern	2.52247545
5	MP0008877_abnormal_DNA_methylation	2.49032381
6	MP0009046_muscle_twitch	2.30162852
7	MP0001968_abnormal_touch/_nociception	2.23907864
8	MP0006292_abnormal_olfactory_placode	2.14918030
9	MP0002736_abnormal_nociception_after	2.09075026
10	MP0003195_calcinosis	2.08597588
11	MP0001984_abnormal_olfaction	2.06910843
12	MP0009745_abnormal_behavioral_response	2.05644290
13	MP0006276_abnormal_autonomic_nervous	2.02376834
14	MP0000778_abnormal_nervous_system	2.00064602
15	MP0003136_yellow_coat_color	1.98778638
16	MP0002653_abnormal_ependyma_morphology	1.97355422
17	MP0004142_abnormal_muscle_tone	1.96274328
18	MP0002272_abnormal_nervous_system	1.88126556
19	MP0001486_abnormal_startle_reflex	1.83596060
20	MP0002837_dystrophic_cardiac_calcinosis	1.75611764
21	MP0006072_abnormal_retinal_apoptosis	1.74569221
22	MP0002638_abnormal_pupillary_reflex	1.73371207
23	MP0004133_heterotaxia	1.72579146
24	MP0002572_abnormal_emotion/affect_behav	1.72024552
25	MP0001501_abnormal_sleep_pattern	1.71593775
26	MP0005253_abnormal_eye_physiology	1.68754622
27	MP0003635_abnormal_synaptic_transmissio	1.67380457
28	MP0002938_white_spotting	1.65503787
29	MP0008872_abnormal_physiological_respon	1.65328031
30	MP0000631_abnormal_neuroendocrine_gland	1.64507713
31	MP0000427_abnormal_hair_cycle	1.64182089
32	MP0004043_abnormal_pH_regulation	1.62947120
33	MP0001529_abnormal_vocalization	1.62333626
34	MP0001485_abnormal_pinna_reflex	1.62229856
35	MP0002557_abnormal_social/conspecific_i	1.61779473
36	MP0004885_abnormal_endolymph	1.61017758
37	MP0003787_abnormal_imprinting	1.55559361
38	MP0002064_seizures	1.53495083
39	MP0002735_abnormal_chemical_nociception	1.52097099
40	MP0005645_abnormal_hypothalamus_physiol	1.50955649
41	MP0002067_abnormal_sensory_capabilities	1.48752995
42	MP0003646_muscle_fatigue	1.48404805
43	MP0004145_abnormal_muscle_electrophysio	1.46347288
44	MP0002063_abnormal_learning/memory/cond	1.46268538
45	MP0003890_abnormal_embryonic-extraembry	1.44374461
46	MP0005646_abnormal_pituitary_gland	1.43336435
47	MP0005386_behavior/neurological_phenoty	1.40679335
48	MP0004924_abnormal_behavior	1.40679335
49	MP0004742_abnormal_vestibular_system	1.31894734
50	MP0004859_abnormal_synaptic_plasticity	1.31753113
51	MP0010386_abnormal_urinary_bladder	1.30067452
52	MP0003283_abnormal_digestive_organ	1.27906066
53	MP0001970_abnormal_pain_threshold	1.25526081
54	MP0001986_abnormal_taste_sensitivity	1.24470637
55	MP0002734_abnormal_mechanical_nocicepti	1.22048018
56	MP0008789_abnormal_olfactory_epithelium	1.20206799
57	MP0002752_abnormal_somatic_nervous	1.19580899
58	MP0002184_abnormal_innervation	1.19112208
59	MP0005174_abnormal_tail_pigmentation	1.19097437
60	MP0002876_abnormal_thyroid_physiology	1.18696188
61	MP0005195_abnormal_posterior_eye	1.18011755
62	MP0005499_abnormal_olfactory_system	1.17597039
63	MP0005394_taste/olfaction_phenotype	1.17597039
64	MP0002733_abnormal_thermal_nociception	1.15399013
65	MP0000955_abnormal_spinal_cord	1.14999259
66	MP0002882_abnormal_neuron_morphology	1.10896718
67	MP0002928_abnormal_bile_duct	1.10784474
68	MP0000383_abnormal_hair_follicle	1.06466229
69	MP0001905_abnormal_dopamine_level	1.04142408
70	MP0002095_abnormal_skin_pigmentation	1.02912856
71	MP0002229_neurodegeneration	1.01971292
72	MP0003119_abnormal_digestive_system	1.01517928
73	MP0000026_abnormal_inner_ear	1.00320436
74	MP0004270_analgesia	1.00209481
75	MP0002138_abnormal_hepatobiliary_system	0.98938010
76	MP0003937_abnormal_limbs/digits/tail_de	0.98772704
77	MP0001440_abnormal_grooming_behavior	0.97924655
78	MP0008875_abnormal_xenobiotic_pharmacok	0.97254069
79	MP0003011_delayed_dark_adaptation	0.96774788
80	MP0002909_abnormal_adrenal_gland	0.93541162
81	MP0002234_abnormal_pharynx_morphology	0.93538432
82	MP0003121_genomic_imprinting	0.92868605
83	MP0003122_maternal_imprinting	0.92324006
84	MP0001293_anophthalmia	0.92110611
85	MP0005423_abnormal_somatic_nervous	0.90485212
86	MP0002751_abnormal_autonomic_nervous	0.89781656
87	MP0001502_abnormal_circadian_rhythm	0.88141034
88	MP0000372_irregular_coat_pigmentation	0.87188115
89	MP0003698_abnormal_male_reproductive	0.84391992
90	MP0002822_catalepsy	0.84021928
91	MP0001963_abnormal_hearing_physiology	0.83360721
92	MP0005187_abnormal_penis_morphology	0.82789280
93	MP0000647_abnormal_sebaceous_gland	0.82574787
94	MP0000230_abnormal_systemic_arterial	0.82548454
95	MP0003137_abnormal_impulse_conducting	0.81961293
96	MP0003878_abnormal_ear_physiology	0.81499423
97	MP0005377_hearing/vestibular/ear_phenot	0.81499423
98	MP0004215_abnormal_myocardial_fiber	0.79884556
99	MP0005084_abnormal_gallbladder_morpholo	0.78984112
100	MP0005391_vision/eye_phenotype	0.78237663

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.58012170
2	Abnormality of midbrain morphology (HP:0002418)	4.39864187
3	Molar tooth sign on MRI (HP:0002419)	4.39864187
4	Pancreatic fibrosis (HP:0100732)	4.30810928
5	True hermaphroditism (HP:0010459)	4.18736577
6	Nephronophthisis (HP:0000090)	3.80099427
7	Hyperventilation (HP:0002883)	3.77597035
8	Medial flaring of the eyebrow (HP:0010747)	3.54837284
9	Abnormality of the renal medulla (HP:0100957)	3.35117534
10	Abnormality of the renal cortex (HP:0011035)	3.24848451
11	Congenital stationary night blindness (HP:0007642)	3.19044027
12	Chronic hepatic failure (HP:0100626)	3.13866274
13	Gait imbalance (HP:0002141)	3.08948136
14	Progressive cerebellar ataxia (HP:0002073)	3.05382395
15	Type II lissencephaly (HP:0007260)	2.98648438
16	Congenital primary aphakia (HP:0007707)	2.93613268
17	Cystic liver disease (HP:0006706)	2.85982617
18	Gaze-evoked nystagmus (HP:0000640)	2.82099003
19	Abolished electroretinogram (ERG) (HP:0000550)	2.81331309
20	Broad-based gait (HP:0002136)	2.78762769
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.78203258
22	Inability to walk (HP:0002540)	2.78182089
23	Nephrogenic diabetes insipidus (HP:0009806)	2.77003193
24	Febrile seizures (HP:0002373)	2.76873364
25	Genetic anticipation (HP:0003743)	2.74315017
26	Tubular atrophy (HP:0000092)	2.73206134
27	Attenuation of retinal blood vessels (HP:0007843)	2.72819001
28	Genital tract atresia (HP:0001827)	2.58863791
29	Progressive inability to walk (HP:0002505)	2.52980850
30	Pendular nystagmus (HP:0012043)	2.50092766
31	Vaginal atresia (HP:0000148)	2.48822547
32	Anencephaly (HP:0002323)	2.48042882
33	Protruding tongue (HP:0010808)	2.45084573
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.44440771
35	Keratoconus (HP:0000563)	2.44272207
36	Increased corneal curvature (HP:0100692)	2.44272207
37	Renal cortical cysts (HP:0000803)	2.40350838
38	Sclerocornea (HP:0000647)	2.37826408
39	Abnormal drinking behavior (HP:0030082)	2.37301766
40	Polydipsia (HP:0001959)	2.37301766
41	Absent speech (HP:0001344)	2.34019228
42	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.30849137
43	Abnormality of alanine metabolism (HP:0010916)	2.30849137
44	Hyperalaninemia (HP:0003348)	2.30849137
45	Congenital hepatic fibrosis (HP:0002612)	2.30257506
46	Cerebellar dysplasia (HP:0007033)	2.29318428
47	Colon cancer (HP:0003003)	2.27173166
48	Lissencephaly (HP:0001339)	2.26642621
49	Intestinal atresia (HP:0011100)	2.26235323
50	Focal motor seizures (HP:0011153)	2.24250428
51	Postaxial foot polydactyly (HP:0001830)	2.21816181
52	Drooling (HP:0002307)	2.20124570
53	Clumsiness (HP:0002312)	2.18445035
54	Oligodactyly (hands) (HP:0001180)	2.17811305
55	Optic nerve hypoplasia (HP:0000609)	2.17421767
56	Hemiparesis (HP:0001269)	2.15373646
57	Focal seizures (HP:0007359)	2.14452295
58	Postaxial hand polydactyly (HP:0001162)	2.13943386
59	Retinal dysplasia (HP:0007973)	2.13819676
60	Poor coordination (HP:0002370)	2.12178754
61	Short tibia (HP:0005736)	2.05458656
62	Abnormal biliary tract physiology (HP:0012439)	2.05266142
63	Bile duct proliferation (HP:0001408)	2.05266142
64	Fair hair (HP:0002286)	2.04456538
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.03513110
66	Decreased central vision (HP:0007663)	2.03367605
67	Male pseudohermaphroditism (HP:0000037)	2.02069536
68	Dialeptic seizures (HP:0011146)	1.99146183
69	Furrowed tongue (HP:0000221)	1.98946976
70	Epileptic encephalopathy (HP:0200134)	1.96904314
71	Preaxial hand polydactyly (HP:0001177)	1.94675472
72	Excessive salivation (HP:0003781)	1.94345211
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92014961
74	Absent/shortened dynein arms (HP:0200106)	1.92014961
75	Abnormal ciliary motility (HP:0012262)	1.90449098
76	Bony spicule pigmentary retinopathy (HP:0007737)	1.89708570
77	Stomach cancer (HP:0012126)	1.89498192
78	Abnormality of the labia minora (HP:0012880)	1.89442950
79	Polyuria (HP:0000103)	1.89052775
80	Narrow forehead (HP:0000341)	1.87984834
81	Abnormality of macular pigmentation (HP:0008002)	1.86721460
82	Pachygyria (HP:0001302)	1.85722738
83	Specific learning disability (HP:0001328)	1.83664093
84	Chorioretinal atrophy (HP:0000533)	1.82462874
85	Large for gestational age (HP:0001520)	1.80777620
86	Limb dystonia (HP:0002451)	1.79933720
87	Abnormal rod and cone electroretinograms (HP:0008323)	1.79261167
88	Dandy-Walker malformation (HP:0001305)	1.78757004
89	Atonic seizures (HP:0010819)	1.77049442
90	Polyphagia (HP:0002591)	1.76994929
91	Short foot (HP:0001773)	1.74913823
92	Astigmatism (HP:0000483)	1.73102816
93	Hypothermia (HP:0002045)	1.71611312
94	Tubulointerstitial abnormality (HP:0001969)	1.71429549
95	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.71320542
96	Abnormal respiratory epithelium morphology (HP:0012253)	1.68860807
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.68860807
98	Septo-optic dysplasia (HP:0100842)	1.68183233
99	Congenital, generalized hypertrichosis (HP:0004540)	1.66475760
100	Highly arched eyebrow (HP:0002553)	1.65165954

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.65455583
2	BMPR1B	3.48492636
3	CASK	2.86074793
4	ADRBK2	2.66892569
5	WNK3	2.65421195
6	MAP3K4	2.62866878
7	ZAK	2.56104640
8	MAP4K2	2.46241284
9	NUAK1	2.40291630
10	MARK1	2.11936357
11	INSRR	2.11779666
12	GRK1	1.98736259
13	ACVR1B	1.94569680
14	MAPK13	1.89080984
15	WNK4	1.77936061
16	PINK1	1.70845143
17	LATS1	1.62870524
18	MAP2K7	1.57034519
19	PAK3	1.54946288
20	STK38L	1.48688106
21	TAOK3	1.47226953
22	TRIM28	1.42802728
23	DAPK2	1.40530228
24	NTRK3	1.38895473
25	TNIK	1.38642955
26	BCR	1.32191774
27	NTRK2	1.31110908
28	PLK2	1.29381990
29	PNCK	1.24235435
30	TGFBR1	1.23878066
31	EPHA4	1.22453634
32	MUSK	1.18030372
33	OXSR1	1.17959010
34	MKNK2	1.16758662
35	STK39	1.14978371
36	PRKCE	1.05007299
37	TLK1	1.03956961
38	CAMKK2	1.03927511
39	PRKCG	1.02424571
40	DYRK2	1.01764492
41	CSNK1G2	1.00032720
42	ADRBK1	0.98670453
43	FGFR2	0.89096923
44	AKT3	0.86999983
45	CSNK1G1	0.85051440
46	CSNK1A1L	0.77684654
47	TIE1	0.76763386
48	CSNK1G3	0.74152182
49	PTK2B	0.70935538
50	STK3	0.68404801
51	PIK3CA	0.68312891
52	CAMK2A	0.67231526
53	EPHB2	0.66937736
54	BCKDK	0.64085208
55	SGK2	0.63924602
56	TXK	0.63636526
57	OBSCN	0.57870996
58	SGK494	0.56576233
59	SGK223	0.56576233
60	STK11	0.54709211
61	DYRK1A	0.54275221
62	PKN1	0.53108230
63	CSNK1D	0.52643344
64	PHKG1	0.52640978
65	PHKG2	0.52640978
66	MINK1	0.50283458
67	SIK2	0.50275606
68	CAMK1	0.49886859
69	PRKACA	0.49238660
70	WNK1	0.49129090
71	ERBB3	0.48063018
72	VRK1	0.47921839
73	MKNK1	0.47652413
74	PLK3	0.47443409
75	MAP2K4	0.47400905
76	TEC	0.45920288
77	PAK6	0.44211192
78	MAPK15	0.42457238
79	PIK3CG	0.41933784
80	STK16	0.41184355
81	PRKCQ	0.39419676
82	TNK2	0.38910399
83	PRKG1	0.38804167
84	ERBB2	0.38121490
85	CAMK1G	0.38072856
86	CDK5	0.37411504
87	BRSK2	0.36810185
88	PRKCH	0.36237941
89	CSNK1A1	0.35999076
90	CDK19	0.35497332
91	NEK2	0.35427826
92	PLK4	0.35333531
93	CDK3	0.35289209
94	PRKCZ	0.35265795
95	STK38	0.35100143
96	FER	0.34107106
97	PRKAA1	0.33950097
98	NLK	0.33526765
99	PRKCA	0.32325764
100	TAF1	0.32087383

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.16360179
2	Nicotine addiction_Homo sapiens_hsa05033	2.97841916
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.57552119
4	Butanoate metabolism_Homo sapiens_hsa00650	2.52225779
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44132934
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42420896
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38939037
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.27263971
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.18516139
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03222047
11	Morphine addiction_Homo sapiens_hsa05032	1.91278584
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.90994895
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88306297
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.86449714
15	Taste transduction_Homo sapiens_hsa04742	1.84852839
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.76004897
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69663159
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.69633753
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.61998046
20	GABAergic synapse_Homo sapiens_hsa04727	1.57257678
21	Protein export_Homo sapiens_hsa03060	1.56719138
22	Caffeine metabolism_Homo sapiens_hsa00232	1.55566539
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50833530
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.50518958
25	Circadian entrainment_Homo sapiens_hsa04713	1.49427064
26	Glutamatergic synapse_Homo sapiens_hsa04724	1.46218155
27	Insulin secretion_Homo sapiens_hsa04911	1.45157173
28	Basal transcription factors_Homo sapiens_hsa03022	1.43316726
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.42981402
30	Olfactory transduction_Homo sapiens_hsa04740	1.41667109
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.34435209
32	ABC transporters_Homo sapiens_hsa02010	1.32286140
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.30847654
34	Propanoate metabolism_Homo sapiens_hsa00640	1.29973430
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29607153
36	Serotonergic synapse_Homo sapiens_hsa04726	1.28816392
37	Homologous recombination_Homo sapiens_hsa03440	1.28298642
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26223483
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25080816
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21218302
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17466442
42	Regulation of autophagy_Homo sapiens_hsa04140	1.09742260
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.09487418
44	Cocaine addiction_Homo sapiens_hsa05030	1.08332471
45	Dopaminergic synapse_Homo sapiens_hsa04728	1.05353862
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03063370
47	Calcium signaling pathway_Homo sapiens_hsa04020	1.02500750
48	Peroxisome_Homo sapiens_hsa04146	1.01794994
49	Salivary secretion_Homo sapiens_hsa04970	0.98002768
50	Parkinsons disease_Homo sapiens_hsa05012	0.95852342
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95130246
52	Retinol metabolism_Homo sapiens_hsa00830	0.93702965
53	RNA polymerase_Homo sapiens_hsa03020	0.93306686
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.91025393
55	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.90258376
56	RNA degradation_Homo sapiens_hsa03018	0.84322017
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84246245
58	Histidine metabolism_Homo sapiens_hsa00340	0.82891208
59	Amphetamine addiction_Homo sapiens_hsa05031	0.82685526
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81280080
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79419303
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79351589
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78058062
64	Long-term depression_Homo sapiens_hsa04730	0.77200008
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76770659
66	Cholinergic synapse_Homo sapiens_hsa04725	0.73558001
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.71696094
68	Huntingtons disease_Homo sapiens_hsa05016	0.70530025
69	Circadian rhythm_Homo sapiens_hsa04710	0.69184391
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.68796885
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65679329
72	Axon guidance_Homo sapiens_hsa04360	0.62625345
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61072931
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59923889
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57974993
76	Gastric acid secretion_Homo sapiens_hsa04971	0.57212687
77	Basal cell carcinoma_Homo sapiens_hsa05217	0.57168729
78	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.50399665
79	Alzheimers disease_Homo sapiens_hsa05010	0.49600679
80	Lysine degradation_Homo sapiens_hsa00310	0.49320293
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.48845717
82	One carbon pool by folate_Homo sapiens_hsa00670	0.48767639
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48663005
84	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.48433214
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45884824
86	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.44710919
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.44200320
88	Metabolic pathways_Homo sapiens_hsa01100	0.43519169
89	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43101424
90	Renin secretion_Homo sapiens_hsa04924	0.42638827
91	Purine metabolism_Homo sapiens_hsa00230	0.41488161
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.40216967
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.40216076
94	Mineral absorption_Homo sapiens_hsa04978	0.37363075
95	Asthma_Homo sapiens_hsa05310	0.35284043
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.34263147
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.30967663
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30027704
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.29131473
100	Ras signaling pathway_Homo sapiens_hsa04014	0.29078287

ZNF470

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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