ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tryptophan catabolic process (GO:0006569)	4.62405999
2	indole-containing compound catabolic process (GO:0042436)	4.62405999
3	indolalkylamine catabolic process (GO:0046218)	4.62405999
4	indolalkylamine metabolic process (GO:0006586)	4.45012796
5	kynurenine metabolic process (GO:0070189)	4.28708585
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.28573495
7	behavioral response to ethanol (GO:0048149)	4.25037682
8	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.24440200
9	tryptophan metabolic process (GO:0006568)	3.86634657
10	behavioral response to nicotine (GO:0035095)	3.84841009
11	cilium or flagellum-dependent cell motility (GO:0001539)	3.74423907
12	L-fucose catabolic process (GO:0042355)	3.66283755
13	fucose catabolic process (GO:0019317)	3.66283755
14	L-fucose metabolic process (GO:0042354)	3.66283755
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.58081297
16	detection of light stimulus involved in visual perception (GO:0050908)	3.58081297
17	reflex (GO:0060004)	3.48592460
18	gamma-aminobutyric acid transport (GO:0015812)	3.39153542
19	regulation of hippo signaling (GO:0035330)	3.38571084
20	amine catabolic process (GO:0009310)	3.38446120
21	cellular biogenic amine catabolic process (GO:0042402)	3.38446120
22	indole-containing compound metabolic process (GO:0042430)	3.37784550
23	neural tube formation (GO:0001841)	3.37635453
24	signal peptide processing (GO:0006465)	3.34717575
25	neuronal action potential propagation (GO:0019227)	3.33878668
26	monoubiquitinated protein deubiquitination (GO:0035520)	3.29962607
27	photoreceptor cell maintenance (GO:0045494)	3.27040379
28	negative regulation of mast cell activation (GO:0033004)	3.23972983
29	membrane depolarization during action potential (GO:0086010)	3.22956399
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.21189225
31	auditory receptor cell stereocilium organization (GO:0060088)	3.16543395
32	piRNA metabolic process (GO:0034587)	3.14745045
33	neuronal action potential (GO:0019228)	3.10601260
34	serotonin metabolic process (GO:0042428)	3.10035873
35	primary amino compound metabolic process (GO:1901160)	3.03372001
36	establishment of protein localization to Golgi (GO:0072600)	3.01210953
37	cellular ketone body metabolic process (GO:0046950)	3.00562142
38	regulation of establishment of cell polarity (GO:2000114)	3.00211615
39	transmission of nerve impulse (GO:0019226)	2.98101591
40	positive regulation of developmental pigmentation (GO:0048087)	2.97780294
41	snRNA transcription (GO:0009301)	2.94774497
42	cellular response to sterol (GO:0036315)	2.93629739
43	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.93095270
44	negative regulation of sodium ion transport (GO:0010766)	2.92893649
45	inner ear receptor stereocilium organization (GO:0060122)	2.90858560
46	postsynaptic membrane organization (GO:0001941)	2.88343122
47	regulation of pigment cell differentiation (GO:0050932)	2.87947368
48	regulation of action potential (GO:0098900)	2.87331004
49	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.87318393
50	tachykinin receptor signaling pathway (GO:0007217)	2.85360022
51	central nervous system neuron axonogenesis (GO:0021955)	2.84074569
52	retinal cone cell development (GO:0046549)	2.84023151
53	regulation of gene silencing by RNA (GO:0060966)	2.77225341
54	regulation of posttranscriptional gene silencing (GO:0060147)	2.77225341
55	regulation of gene silencing by miRNA (GO:0060964)	2.77225341
56	thyroid hormone metabolic process (GO:0042403)	2.76992738
57	regulation of sarcomere organization (GO:0060297)	2.73397035
58	benzene-containing compound metabolic process (GO:0042537)	2.73001356
59	startle response (GO:0001964)	2.71778454
60	protein K48-linked deubiquitination (GO:0071108)	2.71709991
61	oxidative demethylation (GO:0070989)	2.71615694
62	regulation of neurotransmitter uptake (GO:0051580)	2.70594392
63	cilium morphogenesis (GO:0060271)	2.69903006
64	ketone body metabolic process (GO:1902224)	2.67449942
65	pyrimidine nucleobase catabolic process (GO:0006208)	2.67154627
66	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.66443816
67	regulation of translation, ncRNA-mediated (GO:0045974)	2.66443816
68	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.66443816
69	protein K11-linked deubiquitination (GO:0035871)	2.65844895
70	axoneme assembly (GO:0035082)	2.65011723
71	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.64962311
72	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.64920184
73	presynaptic membrane assembly (GO:0097105)	2.64601401
74	central nervous system projection neuron axonogenesis (GO:0021952)	2.63692693
75	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.62669560
76	sex differentiation (GO:0007548)	2.60261631
77	cilium movement (GO:0003341)	2.59281562
78	negative regulation of cAMP-mediated signaling (GO:0043951)	2.57785568
79	response to pheromone (GO:0019236)	2.56242461
80	DNA methylation involved in gamete generation (GO:0043046)	2.56164282
81	epithelial cilium movement (GO:0003351)	2.56054874
82	synaptic transmission, glutamatergic (GO:0035249)	2.54785939
83	interkinetic nuclear migration (GO:0022027)	2.54146240
84	cilium organization (GO:0044782)	2.53901291
85	auditory behavior (GO:0031223)	2.53570202
86	limb development (GO:0060173)	2.53382838
87	appendage development (GO:0048736)	2.53382838
88	NAD biosynthetic process (GO:0009435)	2.52675883
89	opioid receptor signaling pathway (GO:0038003)	2.51468851
90	glutamate receptor signaling pathway (GO:0007215)	2.51199757
91	cAMP catabolic process (GO:0006198)	2.49293900
92	regulation of acrosome reaction (GO:0060046)	2.48672118
93	cilium assembly (GO:0042384)	2.48372305
94	nonmotile primary cilium assembly (GO:0035058)	2.47838201
95	sulfation (GO:0051923)	2.47476966
96	regulation of collateral sprouting (GO:0048670)	2.44875090
97	aromatic amino acid family catabolic process (GO:0009074)	2.43100568
98	protein localization to synapse (GO:0035418)	2.43069320
99	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.42997116
100	presynaptic membrane organization (GO:0097090)	2.42662786

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.66723572
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.35303273
3	VDR_22108803_ChIP-Seq_LS180_Human	3.18241026
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.90926437
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.86057041
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71558480
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69014910
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57844680
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.46789935
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40895636
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.40370973
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.26000153
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.17096220
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.05574740
15	P300_19829295_ChIP-Seq_ESCs_Human	2.04293773
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98085906
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95718886
18	STAT3_23295773_ChIP-Seq_U87_Human	1.93692638
19	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.91118816
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.88417196
21	FUS_26573619_Chip-Seq_HEK293_Human	1.86498695
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.82445540
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.80716695
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.79915681
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.76408311
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.76128873
27	TCF4_23295773_ChIP-Seq_U87_Human	1.75955098
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71095892
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.71095892
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.71004209
31	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70044978
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68443574
33	EWS_26573619_Chip-Seq_HEK293_Human	1.67901214
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65291556
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.60971696
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.59693922
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.59354838
38	AR_25329375_ChIP-Seq_VCAP_Human	1.56373926
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55468068
40	DROSHA_22980978_ChIP-Seq_HELA_Human	1.54476029
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.51200926
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51200926
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50566794
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44899367
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44626879
46	TP53_16413492_ChIP-PET_HCT116_Human	1.42903337
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40904006
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38514193
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37936079
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.37644434
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35314059
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.35165244
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34894219
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33083580
55	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30403334
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.30290075
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30174207
58	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.27574983
59	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.26138689
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25431299
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22935214
62	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22413951
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22400915
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22026086
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20501938
66	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.19929454
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18021181
68	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17800527
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17637538
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17298306
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16922209
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16922209
73	RXR_22108803_ChIP-Seq_LS180_Human	1.15712096
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14925860
75	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.14779282
76	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.14404286
77	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.13384640
78	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.13383227
79	KDM2B_26808549_Chip-Seq_REH_Human	1.11414906
80	AHR_22903824_ChIP-Seq_MCF-7_Human	1.10749425
81	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.10670225
82	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10034730
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09708630
84	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09300095
85	TP53_22573176_ChIP-Seq_HFKS_Human	1.08978888
86	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.08359435
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.08338903
88	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07377016
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07060284
90	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06518629
91	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06398329
92	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05971620
93	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04791211
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00458144
95	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.99586155
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.99442421
97	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.99244591
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98941619
99	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97781761
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96885517

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.11975713
2	MP0001968_abnormal_touch/_nociception	3.05363171
3	MP0003195_calcinosis	2.91254521
4	MP0009046_muscle_twitch	2.87876147
5	MP0005551_abnormal_eye_electrophysiolog	2.64896598
6	MP0003646_muscle_fatigue	2.58276354
7	MP0002736_abnormal_nociception_after	2.56970312
8	MP0001501_abnormal_sleep_pattern	2.56463997
9	MP0003787_abnormal_imprinting	2.41635068
10	MP0008877_abnormal_DNA_methylation	2.41232248
11	MP0001486_abnormal_startle_reflex	2.29537921
12	MP0009745_abnormal_behavioral_response	2.28997749
13	MP0002735_abnormal_chemical_nociception	2.17148934
14	MP0003136_yellow_coat_color	2.04540712
15	MP0006276_abnormal_autonomic_nervous	2.03692660
16	MP0002272_abnormal_nervous_system	1.96989509
17	MP0008057_abnormal_DNA_replication	1.89809324
18	MP0005646_abnormal_pituitary_gland	1.86736888
19	MP0003880_abnormal_central_pattern	1.86059672
20	MP0004043_abnormal_pH_regulation	1.80812215
21	MP0002876_abnormal_thyroid_physiology	1.75153511
22	MP0003635_abnormal_synaptic_transmissio	1.73011999
23	MP0002064_seizures	1.70038632
24	MP0000427_abnormal_hair_cycle	1.69925507
25	MP0002572_abnormal_emotion/affect_behav	1.69593378
26	MP0001986_abnormal_taste_sensitivity	1.69275259
27	MP0001485_abnormal_pinna_reflex	1.66439622
28	MP0001984_abnormal_olfaction	1.63327296
29	MP0008872_abnormal_physiological_respon	1.62924923
30	MP0005253_abnormal_eye_physiology	1.60981318
31	MP0004142_abnormal_muscle_tone	1.59605638
32	MP0001970_abnormal_pain_threshold	1.58325092
33	MP0002067_abnormal_sensory_capabilities	1.54275157
34	MP0003950_abnormal_plasma_membrane	1.54226164
35	MP0002102_abnormal_ear_morphology	1.54097751
36	MP0002733_abnormal_thermal_nociception	1.52204773
37	MP0004885_abnormal_endolymph	1.51989146
38	MP0005386_behavior/neurological_phenoty	1.49392280
39	MP0004924_abnormal_behavior	1.49392280
40	MP0002837_dystrophic_cardiac_calcinosis	1.48403692
41	MP0002063_abnormal_learning/memory/cond	1.45800669
42	MP0002557_abnormal_social/conspecific_i	1.39041941
43	MP0010386_abnormal_urinary_bladder	1.38247733
44	MP0005645_abnormal_hypothalamus_physiol	1.37564953
45	MP0004145_abnormal_muscle_electrophysio	1.36584395
46	MP0004859_abnormal_synaptic_plasticity	1.36519120
47	MP0000778_abnormal_nervous_system	1.35355230
48	MP0006072_abnormal_retinal_apoptosis	1.32455774
49	MP0002638_abnormal_pupillary_reflex	1.31847982
50	MP0005174_abnormal_tail_pigmentation	1.31110375
51	MP0002734_abnormal_mechanical_nocicepti	1.30754898
52	MP0003045_fibrosis	1.28638139
53	MP0004742_abnormal_vestibular_system	1.24731035
54	MP0003633_abnormal_nervous_system	1.24522699
55	MP0000631_abnormal_neuroendocrine_gland	1.23910735
56	MP0005423_abnormal_somatic_nervous	1.22676115
57	MP0000383_abnormal_hair_follicle	1.22208075
58	MP0003252_abnormal_bile_duct	1.16387320
59	MP0000230_abnormal_systemic_arterial	1.12093360
60	MP0004147_increased_porphyrin_level	1.11692063
61	MP0000372_irregular_coat_pigmentation	1.09797916
62	MP0004130_abnormal_muscle_cell	1.08698704
63	MP0002928_abnormal_bile_duct	1.08666303
64	MP0003121_genomic_imprinting	1.08410067
65	MP0002229_neurodegeneration	1.07141553
66	MP0001440_abnormal_grooming_behavior	1.04612852
67	MP0002653_abnormal_ependyma_morphology	1.01222556
68	MP0003879_abnormal_hair_cell	1.01105094
69	MP0002168_other_aberrant_phenotype	1.00984487
70	MP0002138_abnormal_hepatobiliary_system	0.99632166
71	MP0002938_white_spotting	0.98158293
72	MP0002882_abnormal_neuron_morphology	0.97786038
73	MP0005195_abnormal_posterior_eye	0.97693507
74	MP0002752_abnormal_somatic_nervous	0.97672526
75	MP0009780_abnormal_chondrocyte_physiolo	0.96688884
76	MP0001963_abnormal_hearing_physiology	0.93783772
77	MP0003890_abnormal_embryonic-extraembry	0.93574308
78	MP0005171_absent_coat_pigmentation	0.92974675
79	MP0002184_abnormal_innervation	0.91801660
80	MP0000955_abnormal_spinal_cord	0.91082990
81	MP0002095_abnormal_skin_pigmentation	0.90748160
82	MP0005410_abnormal_fertilization	0.90664927
83	MP0004215_abnormal_myocardial_fiber	0.90178542
84	MP0003631_nervous_system_phenotype	0.89724628
85	MP0005670_abnormal_white_adipose	0.88812613
86	MP0003698_abnormal_male_reproductive	0.88526530
87	MP0000538_abnormal_urinary_bladder	0.88211122
88	MP0005377_hearing/vestibular/ear_phenot	0.87446255
89	MP0003878_abnormal_ear_physiology	0.87446255
90	MP0003137_abnormal_impulse_conducting	0.87090550
91	MP0006054_spinal_hemorrhage	0.86025147
92	MP0000026_abnormal_inner_ear	0.83034741
93	MP0006292_abnormal_olfactory_placode	0.79743801
94	MP0005167_abnormal_blood-brain_barrier	0.79334903
95	MP0004085_abnormal_heartbeat	0.78804549
96	MP0004270_analgesia	0.78589528
97	MP0004133_heterotaxia	0.78304625
98	MP0005187_abnormal_penis_morphology	0.75811786
99	MP0008875_abnormal_xenobiotic_pharmacok	0.74827432
100	MP0005395_other_phenotype	0.74799781

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.91561545
2	Genetic anticipation (HP:0003743)	4.65821831
3	Pancreatic cysts (HP:0001737)	4.65452882
4	Gaze-evoked nystagmus (HP:0000640)	4.37319599
5	True hermaphroditism (HP:0010459)	4.27555864
6	Pancreatic fibrosis (HP:0100732)	4.22382921
7	Progressive cerebellar ataxia (HP:0002073)	4.00797012
8	Molar tooth sign on MRI (HP:0002419)	3.85254619
9	Abnormality of midbrain morphology (HP:0002418)	3.85254619
10	Nephronophthisis (HP:0000090)	3.34598661
11	Protruding tongue (HP:0010808)	3.32726607
12	Congenital stationary night blindness (HP:0007642)	3.31269163
13	Cystic liver disease (HP:0006706)	3.27881329
14	Focal seizures (HP:0007359)	3.25465469
15	Chronic hepatic failure (HP:0100626)	3.24579395
16	Focal motor seizures (HP:0011153)	3.23089047
17	Febrile seizures (HP:0002373)	3.19367803
18	Abnormality of the renal cortex (HP:0011035)	3.18015992
19	Attenuation of retinal blood vessels (HP:0007843)	3.17644233
20	Medial flaring of the eyebrow (HP:0010747)	3.14010375
21	Abnormality of the renal medulla (HP:0100957)	3.13494069
22	Type II lissencephaly (HP:0007260)	3.00818022
23	Broad-based gait (HP:0002136)	2.86209270
24	Absent speech (HP:0001344)	2.83041775
25	Thyroid-stimulating hormone excess (HP:0002925)	2.81909412
26	Clumsiness (HP:0002312)	2.78186480
27	Gait imbalance (HP:0002141)	2.77786830
28	Tubular atrophy (HP:0000092)	2.75193600
29	Cerebellar dysplasia (HP:0007033)	2.73956301
30	Dialeptic seizures (HP:0011146)	2.69288963
31	Increased corneal curvature (HP:0100692)	2.67201929
32	Keratoconus (HP:0000563)	2.67201929
33	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.61180350
34	Bony spicule pigmentary retinopathy (HP:0007737)	2.61000700
35	Congenital primary aphakia (HP:0007707)	2.59293430
36	Fair hair (HP:0002286)	2.57343520
37	Inability to walk (HP:0002540)	2.56382947
38	Abolished electroretinogram (ERG) (HP:0000550)	2.55618570
39	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.40544190
40	Large for gestational age (HP:0001520)	2.39608446
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.37255644
42	Nephrogenic diabetes insipidus (HP:0009806)	2.36572211
43	Absence seizures (HP:0002121)	2.35799574
44	Abnormal drinking behavior (HP:0030082)	2.34473569
45	Polydipsia (HP:0001959)	2.34473569
46	Sclerocornea (HP:0000647)	2.33674367
47	Progressive inability to walk (HP:0002505)	2.33671258
48	Furrowed tongue (HP:0000221)	2.30995067
49	Genital tract atresia (HP:0001827)	2.30028763
50	Congenital hepatic fibrosis (HP:0002612)	2.29879842
51	Hemiparesis (HP:0001269)	2.27148981
52	Congenital sensorineural hearing impairment (HP:0008527)	2.26414881
53	Intestinal atresia (HP:0011100)	2.24210324
54	Volvulus (HP:0002580)	2.23957170
55	Vaginal atresia (HP:0000148)	2.21771216
56	Hypoplastic ischia (HP:0003175)	2.20406048
57	Lissencephaly (HP:0001339)	2.18700419
58	Pendular nystagmus (HP:0012043)	2.16026104
59	Anencephaly (HP:0002323)	2.15192608
60	Poor coordination (HP:0002370)	2.14499694
61	Abnormal rod and cone electroretinograms (HP:0008323)	2.13547172
62	Atonic seizures (HP:0010819)	2.13094017
63	Abnormality of the ischium (HP:0003174)	2.12730489
64	Central scotoma (HP:0000603)	2.11138797
65	Male pseudohermaphroditism (HP:0000037)	2.06744282
66	Widely spaced teeth (HP:0000687)	2.05669436
67	Decreased central vision (HP:0007663)	2.04267740
68	Drooling (HP:0002307)	2.03453404
69	Postaxial foot polydactyly (HP:0001830)	2.02184419
70	Generalized hypopigmentation of hair (HP:0011358)	2.01984096
71	Urinary bladder sphincter dysfunction (HP:0002839)	1.99577282
72	Short foot (HP:0001773)	1.97943941
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97532489
74	Absent/shortened dynein arms (HP:0200106)	1.97532489
75	Renal cortical cysts (HP:0000803)	1.97026553
76	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.94670347
77	Dysmetric saccades (HP:0000641)	1.91953265
78	Tented upper lip vermilion (HP:0010804)	1.91901410
79	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.91162701
80	Stomach cancer (HP:0012126)	1.88410505
81	Bile duct proliferation (HP:0001408)	1.87151666
82	Abnormal biliary tract physiology (HP:0012439)	1.87151666
83	Abnormality of macular pigmentation (HP:0008002)	1.87150002
84	Decreased circulating renin level (HP:0003351)	1.84304432
85	Highly arched eyebrow (HP:0002553)	1.84248487
86	Retinitis pigmentosa (HP:0000510)	1.83097992
87	Preaxial foot polydactyly (HP:0001841)	1.81993475
88	Tubulointerstitial nephritis (HP:0001970)	1.81319318
89	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81221145
90	Chorioretinal atrophy (HP:0000533)	1.80190245
91	Small hand (HP:0200055)	1.80056911
92	Hypoplasia of the pons (HP:0012110)	1.79918835
93	Excessive salivation (HP:0003781)	1.79828737
94	Epileptic encephalopathy (HP:0200134)	1.79762608
95	Oligodactyly (hands) (HP:0001180)	1.79373149
96	Polyuria (HP:0000103)	1.78557182
97	Tubulointerstitial abnormality (HP:0001969)	1.76951772
98	Abnormal ciliary motility (HP:0012262)	1.76559121
99	Astigmatism (HP:0000483)	1.76056006
100	Preaxial hand polydactyly (HP:0001177)	1.75024143

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	9.23527103
2	ACVR1B	3.22574070
3	ADRBK2	3.18737052
4	BMPR1B	2.95386859
5	CASK	2.79223525
6	NTRK3	2.33147040
7	GRK1	2.03536139
8	WNK3	2.02225232
9	MAPK13	1.98275120
10	PINK1	1.91226541
11	MKNK2	1.89018758
12	MARK1	1.71143697
13	NUAK1	1.66576945
14	OXSR1	1.62493266
15	INSRR	1.57836900
16	MAP4K2	1.57334696
17	MAP3K4	1.41915755
18	STK38L	1.37997767
19	TNIK	1.36779517
20	TAOK3	1.35884831
21	ADRBK1	1.26584060
22	PNCK	1.25073759
23	AKT3	1.23765604
24	PAK3	1.16976266
25	STK39	1.12930744
26	DAPK2	1.09644728
27	ZAK	1.09309400
28	TGFBR1	1.07291339
29	EPHA4	1.05934593
30	PIK3CG	1.04903893
31	PRKCG	1.00090460
32	PRKCE	0.96737892
33	NTRK2	0.85798505
34	PTK2B	0.84153873
35	LATS1	0.82574105
36	FER	0.78240582
37	WNK4	0.77051855
38	TNK2	0.75912036
39	PKN1	0.75183653
40	PIK3CA	0.74854177
41	CAMK1G	0.74807845
42	SGK2	0.74045096
43	MKNK1	0.73152025
44	PLK2	0.70995675
45	TEC	0.69856659
46	CAMK2A	0.69711299
47	FGFR2	0.68407154
48	STK3	0.67910321
49	CDK19	0.67891971
50	CSNK1G1	0.67553369
51	CSNK1A1L	0.67050013
52	CSNK1G2	0.66138107
53	MAPK15	0.60550722
54	MAP3K7	0.60047744
55	PRKAA2	0.59285285
56	CAMK1	0.57148236
57	SIK2	0.57109689
58	OBSCN	0.56823815
59	STK38	0.56560591
60	PHKG2	0.55048158
61	PHKG1	0.55048158
62	TIE1	0.52999206
63	CAMKK2	0.52459379
64	NLK	0.50276378
65	CSNK1G3	0.49350075
66	PRKCH	0.48791658
67	TXK	0.48479258
68	ERBB2	0.47710863
69	CAMK1D	0.46950971
70	PRKAA1	0.46825859
71	MAP2K7	0.46721310
72	STK11	0.44827951
73	CSNK1D	0.44746064
74	SGK1	0.44668493
75	IRAK1	0.42756639
76	BCR	0.42325480
77	KIT	0.42263043
78	DYRK1A	0.42017194
79	SGK223	0.41262240
80	SGK494	0.41262240
81	DYRK2	0.40175959
82	MARK3	0.39827101
83	MAP2K1	0.39209632
84	PRKACA	0.39185339
85	BRSK2	0.37547719
86	MAPKAPK5	0.36464400
87	TLK1	0.36419392
88	MUSK	0.36339898
89	CSNK1A1	0.36273198
90	CAMK4	0.35866356
91	CDK3	0.35124181
92	PRKG1	0.35050197
93	TRPM7	0.34992326
94	CDK5	0.34206237
95	PRKACB	0.33867403
96	EPHA3	0.32339456
97	PRKCZ	0.32316255
98	TRIM28	0.31111714
99	PRKCA	0.29562207
100	MINK1	0.28664269

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.85419638
2	Phototransduction_Homo sapiens_hsa04744	2.77428806
3	Butanoate metabolism_Homo sapiens_hsa00650	2.67116278
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34063020
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.33195780
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.28958540
7	ABC transporters_Homo sapiens_hsa02010	2.22442936
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.18699851
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.16155864
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.15902882
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.08995393
12	Taste transduction_Homo sapiens_hsa04742	1.97929826
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.96564280
14	Morphine addiction_Homo sapiens_hsa05032	1.86473388
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.81157211
16	Olfactory transduction_Homo sapiens_hsa04740	1.79410781
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.77995978
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.75609297
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.73589252
20	Circadian entrainment_Homo sapiens_hsa04713	1.71100395
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.64891934
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59575714
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.58469278
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.54191201
25	Insulin secretion_Homo sapiens_hsa04911	1.44409911
26	Salivary secretion_Homo sapiens_hsa04970	1.43978294
27	Glycerolipid metabolism_Homo sapiens_hsa00561	1.43712801
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41806835
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41256576
30	GABAergic synapse_Homo sapiens_hsa04727	1.40361143
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38303099
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.37980200
33	Histidine metabolism_Homo sapiens_hsa00340	1.33281275
34	Serotonergic synapse_Homo sapiens_hsa04726	1.31135386
35	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.29821143
36	Calcium signaling pathway_Homo sapiens_hsa04020	1.28123753
37	Homologous recombination_Homo sapiens_hsa03440	1.25733257
38	Caffeine metabolism_Homo sapiens_hsa00232	1.25334402
39	Propanoate metabolism_Homo sapiens_hsa00640	1.23216873
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20397713
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18698509
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16991517
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.15520704
44	Retinol metabolism_Homo sapiens_hsa00830	1.13931500
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12623196
46	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.12037151
47	Long-term depression_Homo sapiens_hsa04730	1.05156566
48	Lysine degradation_Homo sapiens_hsa00310	1.01834499
49	Gastric acid secretion_Homo sapiens_hsa04971	0.98104949
50	Dopaminergic synapse_Homo sapiens_hsa04728	0.95658554
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.94010838
52	Cholinergic synapse_Homo sapiens_hsa04725	0.92698493
53	cAMP signaling pathway_Homo sapiens_hsa04024	0.91460098
54	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.88384135
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85686901
56	Sphingolipid metabolism_Homo sapiens_hsa00600	0.85462565
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82486272
58	Cocaine addiction_Homo sapiens_hsa05030	0.82315949
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81860577
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78564583
61	Renin secretion_Homo sapiens_hsa04924	0.76947487
62	Pancreatic secretion_Homo sapiens_hsa04972	0.73792724
63	Amphetamine addiction_Homo sapiens_hsa05031	0.73366501
64	Peroxisome_Homo sapiens_hsa04146	0.72548835
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71781015
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71555639
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.70659411
68	Fatty acid degradation_Homo sapiens_hsa00071	0.70154660
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.68662552
70	Circadian rhythm_Homo sapiens_hsa04710	0.66939831
71	Regulation of autophagy_Homo sapiens_hsa04140	0.61403711
72	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.58571659
73	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.57950679
74	Bile secretion_Homo sapiens_hsa04976	0.54359922
75	Basal transcription factors_Homo sapiens_hsa03022	0.54104944
76	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.50697518
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.46070094
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.45657633
79	Type II diabetes mellitus_Homo sapiens_hsa04930	0.44726566
80	Mineral absorption_Homo sapiens_hsa04978	0.43717783
81	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43197365
82	Axon guidance_Homo sapiens_hsa04360	0.41891369
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.41673088
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36326423
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.35516788
86	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.35506987
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34732377
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.34227624
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33918822
90	Ras signaling pathway_Homo sapiens_hsa04014	0.33378406
91	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.31905502
92	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.31642657
93	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.29042196
94	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.28017999
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.27281720
96	Platelet activation_Homo sapiens_hsa04611	0.26989638
97	One carbon pool by folate_Homo sapiens_hsa00670	0.26275326
98	Estrogen signaling pathway_Homo sapiens_hsa04915	0.25804221
99	MAPK signaling pathway_Homo sapiens_hsa04010	0.24932247
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.23486852

ZNF471

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »