ZNF473

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.33716696
2cilium or flagellum-dependent cell motility (GO:0001539)7.36704668
3cilium movement (GO:0003341)6.26362413
4motile cilium assembly (GO:0044458)6.17346909
5epithelial cilium movement (GO:0003351)5.80780879
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.37640511
7microtubule depolymerization (GO:0007019)4.96879531
8synapsis (GO:0007129)4.79748582
9regulation of cilium movement (GO:0003352)4.77236844
10centriole assembly (GO:0098534)4.67211159
11nuclear pore complex assembly (GO:0051292)4.66395977
12negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.55368145
13regulation of centriole replication (GO:0046599)4.54043370
14centriole replication (GO:0007099)4.49035338
15mitotic chromosome condensation (GO:0007076)4.30161985
16axoneme assembly (GO:0035082)4.28517763
17piRNA metabolic process (GO:0034587)4.27563958
18chromosome organization involved in meiosis (GO:0070192)4.26977903
19male meiosis I (GO:0007141)4.24289408
20chromosome condensation (GO:0030261)4.21338691
21microtubule polymerization or depolymerization (GO:0031109)4.17598983
22nuclear pore organization (GO:0006999)4.15652147
23meiotic chromosome segregation (GO:0045132)4.10787999
24DNA packaging (GO:0006323)4.04576204
25regulation of retinoic acid receptor signaling pathway (GO:0048385)3.98688049
26mitotic sister chromatid segregation (GO:0000070)3.96796939
27binding of sperm to zona pellucida (GO:0007339)3.91137148
28DNA synthesis involved in DNA repair (GO:0000731)3.81406458
29synaptonemal complex assembly (GO:0007130)3.75932339
30sister chromatid segregation (GO:0000819)3.74833726
31meiosis I (GO:0007127)3.74493417
32male meiosis (GO:0007140)3.73073229
33mitotic nuclear envelope disassembly (GO:0007077)3.71747291
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.70651632
35mitotic metaphase plate congression (GO:0007080)3.70009965
36rRNA methylation (GO:0031167)3.69238778
37metaphase plate congression (GO:0051310)3.64663951
38intraciliary transport (GO:0042073)3.63796733
39rRNA modification (GO:0000154)3.61464097
40nuclear envelope disassembly (GO:0051081)3.60823050
41membrane disassembly (GO:0030397)3.60823050
42DNA replication initiation (GO:0006270)3.50511765
43DNA strand elongation involved in DNA replication (GO:0006271)3.49948753
44left/right pattern formation (GO:0060972)3.48019946
45DNA unwinding involved in DNA replication (GO:0006268)3.46959723
46regulation of spindle organization (GO:0090224)3.46640692
47meiotic nuclear division (GO:0007126)3.45925681
48DNA strand elongation (GO:0022616)3.45887371
49sperm motility (GO:0030317)3.43768620
50synaptonemal complex organization (GO:0070193)3.43532409
51pore complex assembly (GO:0046931)3.42670394
52sperm-egg recognition (GO:0035036)3.34332735
53DNA replication checkpoint (GO:0000076)3.31756413
54sister chromatid cohesion (GO:0007062)3.29360382
55mitotic sister chromatid cohesion (GO:0007064)3.28476829
56regulation of centrosome cycle (GO:0046605)3.27448406
57protein localization to chromosome (GO:0034502)3.26602014
58protein localization to kinetochore (GO:0034501)3.26497353
59regulation of mitotic spindle organization (GO:0060236)3.23692934
60histone exchange (GO:0043486)3.22782841
61protein localization to chromosome, centromeric region (GO:0071459)3.21990950
62meiotic cell cycle process (GO:1903046)3.21299810
63CENP-A containing nucleosome assembly (GO:0034080)3.17500874
64regulation of DNA endoreduplication (GO:0032875)3.15462970
65DNA methylation involved in gamete generation (GO:0043046)3.14775734
66telomere maintenance via semi-conservative replication (GO:0032201)3.13871188
67spermatid development (GO:0007286)3.12905546
68microtubule bundle formation (GO:0001578)3.10425159
69histone H2A acetylation (GO:0043968)3.10100593
70DNA ligation (GO:0006266)3.09730317
71diterpenoid biosynthetic process (GO:0016102)3.08658143
72regulation of chromosome segregation (GO:0051983)3.08536113
73resolution of meiotic recombination intermediates (GO:0000712)3.05117712
74left/right axis specification (GO:0070986)3.03399725
75regulation of microtubule-based movement (GO:0060632)3.02402221
76chromatin remodeling at centromere (GO:0031055)2.99437405
77cilium organization (GO:0044782)2.98207563
78regulation of centrosome duplication (GO:0010824)2.96173917
79spindle checkpoint (GO:0031577)2.94382940
80ventricular system development (GO:0021591)2.93146441
81meiotic cell cycle (GO:0051321)2.92453494
82mitotic spindle checkpoint (GO:0071174)2.89188634
83cilium assembly (GO:0042384)2.87549331
84chromosome organization (GO:0051276)2.86959968
85establishment of chromosome localization (GO:0051303)2.86230999
86single strand break repair (GO:0000012)2.86191930
87chromosome segregation (GO:0007059)2.84874273
88negative regulation of chromosome segregation (GO:0051985)2.83971285
89regulation of meiosis I (GO:0060631)2.83046446
90DNA conformation change (GO:0071103)2.82604428
91protein polyglutamylation (GO:0018095)2.82133795
92attachment of spindle microtubules to kinetochore (GO:0008608)2.81870753
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80184684
94nuclear envelope organization (GO:0006998)2.80158259
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79842440
96negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79842440
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.79842440
98negative regulation of sister chromatid segregation (GO:0033046)2.79842440
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79842440
100rRNA catabolic process (GO:0016075)2.76727494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.74183298
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.05362830
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.04297034
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.03238854
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.89355040
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.78748495
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.99123892
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.91053530
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84180438
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82307909
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.68427122
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49392171
13AR_21909140_ChIP-Seq_LNCAP_Human2.41502398
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.39069949
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33391339
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29095284
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28102590
18DCP1A_22483619_ChIP-Seq_HELA_Human2.22107391
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16169654
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.11715580
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09677350
22GABP_19822575_ChIP-Seq_HepG2_Human2.08149497
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04318621
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03380067
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.00108125
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99475073
27TTF2_22483619_ChIP-Seq_HELA_Human1.99360825
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.97088689
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96694796
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95498065
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92048145
32KDM5A_27292631_Chip-Seq_BREAST_Human1.90839153
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88329295
34* VDR_23849224_ChIP-Seq_CD4+_Human1.87819419
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80236989
36ZNF274_21170338_ChIP-Seq_K562_Hela1.79182717
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79134269
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78175970
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77432890
40XRN2_22483619_ChIP-Seq_HELA_Human1.76774878
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74578155
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71051331
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67675837
44ELK1_19687146_ChIP-ChIP_HELA_Human1.61186585
45FOXP3_21729870_ChIP-Seq_TREG_Human1.59376198
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58854426
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.58090863
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55934358
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52919979
50CIITA_25753668_ChIP-Seq_RAJI_Human1.50616278
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49957136
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48654760
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48517067
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.47307008
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41660526
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37425763
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36745914
58MYC_18940864_ChIP-ChIP_HL60_Human1.33280013
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.31723949
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30165673
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24783542
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.24361224
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.24007928
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.23875032
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20207355
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18900651
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13092056
68EWS_26573619_Chip-Seq_HEK293_Human1.11057236
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10892331
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10199828
71FUS_26573619_Chip-Seq_HEK293_Human1.09647902
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09409354
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06713588
74CHD1_26751641_Chip-Seq_LNCaP_Human1.03870935
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03509613
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02566919
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01540113
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00275063
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96886902
80TFEB_21752829_ChIP-Seq_HELA_Human0.94363424
81FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93116453
82PHF8_20622853_ChIP-Seq_HELA_Human0.91624825
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.91326574
84CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88081174
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87086596
86E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87062731
87RBPJ_21746931_ChIP-Seq_IB4_Human0.85934473
88HNFA_21074721_ChIP-Seq_CACO-2_Human0.83830913
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82499335
90ETV1_20927104_ChIP-Seq_GIST48_Human0.80792413
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.80333413
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80085447
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79839473
94NFYB_21822215_ChIP-Seq_K562_Human0.76918977
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75253059
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.73678442
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71468310
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71215611
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70455625
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.69074498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.27271316
2MP0008057_abnormal_DNA_replication4.17571383
3MP0008058_abnormal_DNA_repair4.12532999
4MP0010094_abnormal_chromosome_stability3.97270946
5MP0003111_abnormal_nucleus_morphology3.48710594
6MP0003077_abnormal_cell_cycle3.46498823
7MP0001929_abnormal_gametogenesis2.93098846
8MP0004957_abnormal_blastocyst_morpholog2.91335144
9MP0003718_maternal_effect2.70417748
10MP0008877_abnormal_DNA_methylation2.69774673
11MP0002210_abnormal_sex_determination2.55230724
12MP0005410_abnormal_fertilization2.47989794
13MP0003698_abnormal_male_reproductive2.40593018
14MP0008007_abnormal_cellular_replicative2.40411378
15MP0002653_abnormal_ependyma_morphology2.39864987
16MP0002132_abnormal_respiratory_system2.17184005
17MP0008932_abnormal_embryonic_tissue2.08702651
18MP0008995_early_reproductive_senescence2.06055285
19MP0001145_abnormal_male_reproductive2.03252893
20MP0008789_abnormal_olfactory_epithelium1.98247343
21MP0002160_abnormal_reproductive_system1.93783396
22MP0000653_abnormal_sex_gland1.90861797
23MP0003786_premature_aging1.89207316
24MP0010307_abnormal_tumor_latency1.73821913
25MP0000678_abnormal_parathyroid_gland1.71187993
26MP0005499_abnormal_olfactory_system1.54114872
27MP0005394_taste/olfaction_phenotype1.54114872
28MP0002161_abnormal_fertility/fecundity1.53875397
29MP0001346_abnormal_lacrimal_gland1.51139945
30MP0000350_abnormal_cell_proliferation1.50351887
31MP0008875_abnormal_xenobiotic_pharmacok1.50065444
32MP0002084_abnormal_developmental_patter1.44560534
33MP0003890_abnormal_embryonic-extraembry1.43436875
34MP0001730_embryonic_growth_arrest1.43305233
35MP0005380_embryogenesis_phenotype1.41666191
36MP0001672_abnormal_embryogenesis/_devel1.41666191
37MP0001697_abnormal_embryo_size1.39345505
38MP0002085_abnormal_embryonic_tissue1.32437506
39MP0002080_prenatal_lethality1.31617134
40MP0005389_reproductive_system_phenotype1.22535763
41MP0000313_abnormal_cell_death1.19998419
42MP0002233_abnormal_nose_morphology1.18155713
43MP0005367_renal/urinary_system_phenotyp1.17569701
44MP0000516_abnormal_urinary_system1.17569701
45MP0001119_abnormal_female_reproductive1.16374351
46MP0005076_abnormal_cell_differentiation1.14337664
47MP0002282_abnormal_trachea_morphology1.12445976
48MP0001293_anophthalmia1.11169505
49MP0003984_embryonic_growth_retardation1.08781466
50MP0003943_abnormal_hepatobiliary_system1.07986755
51MP0003699_abnormal_female_reproductive1.07973344
52MP0005395_other_phenotype1.07005829
53MP0001984_abnormal_olfaction1.06316345
54MP0003937_abnormal_limbs/digits/tail_de1.05985183
55MP0002088_abnormal_embryonic_growth/wei1.04975428
56MP0005083_abnormal_biliary_tract1.04009547
57MP0000358_abnormal_cell_content/1.02694489
58MP0001529_abnormal_vocalization1.02385878
59MP0009697_abnormal_copulation1.02036054
60MP0006292_abnormal_olfactory_placode0.96947898
61MP0009703_decreased_birth_body0.95463934
62MP0002102_abnormal_ear_morphology0.94960249
63MP0004264_abnormal_extraembryonic_tissu0.94284889
64MP0000427_abnormal_hair_cycle0.93308452
65MP0004197_abnormal_fetal_growth/weight/0.92907934
66MP0003656_abnormal_erythrocyte_physiolo0.90923071
67MP0005623_abnormal_meninges_morphology0.90527309
68MP0003861_abnormal_nervous_system0.89146572
69MP0006035_abnormal_mitochondrial_morpho0.87943540
70MP0005670_abnormal_white_adipose0.80679751
71MP0002086_abnormal_extraembryonic_tissu0.79662550
72MP0002249_abnormal_larynx_morphology0.75709484
73MP0003935_abnormal_craniofacial_develop0.75655565
74MP0006036_abnormal_mitochondrial_physio0.74866912
75MP0004808_abnormal_hematopoietic_stem0.73709769
76MP0001188_hyperpigmentation0.72494789
77MP0001286_abnormal_eye_development0.72466784
78MP0010030_abnormal_orbit_morphology0.70916663
79MP0002234_abnormal_pharynx_morphology0.70669803
80MP0002019_abnormal_tumor_incidence0.68908402
81MP0003755_abnormal_palate_morphology0.68813674
82MP0000383_abnormal_hair_follicle0.68542461
83MP0005310_abnormal_salivary_gland0.65076342
84MP0002111_abnormal_tail_morphology0.63876284
85MP0000631_abnormal_neuroendocrine_gland0.63478074
86MP0003942_abnormal_urinary_system0.62811598
87MP0004133_heterotaxia0.62682508
88MP0000372_irregular_coat_pigmentation0.61634737
89MP0000049_abnormal_middle_ear0.59811950
90MP0003878_abnormal_ear_physiology0.59240124
91MP0005377_hearing/vestibular/ear_phenot0.59240124
92MP0002116_abnormal_craniofacial_bone0.58532199
93MP0003936_abnormal_reproductive_system0.58341506
94MP0005647_abnormal_sex_gland0.57689975
95MP0001727_abnormal_embryo_implantation0.57563092
96MP0005391_vision/eye_phenotype0.57276209
97MP0002938_white_spotting0.57083601
98MP0000534_abnormal_ureter_morphology0.56589654
99MP0005384_cellular_phenotype0.56449582
100MP0001919_abnormal_reproductive_system0.55195102

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.40752824
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.44050159
3Absent/shortened dynein arms (HP:0200106)7.44050159
4Abnormal respiratory epithelium morphology (HP:0012253)7.32014927
5Abnormal respiratory motile cilium morphology (HP:0005938)7.32014927
6Abnormal respiratory motile cilium physiology (HP:0012261)7.28066541
7Abnormal ciliary motility (HP:0012262)7.04981833
8Rhinitis (HP:0012384)6.78461329
9Chronic bronchitis (HP:0004469)5.18696698
10Bronchiectasis (HP:0002110)4.63394331
11Tubulointerstitial nephritis (HP:0001970)4.45911790
12Male infertility (HP:0003251)4.11751929
13Nasal polyposis (HP:0100582)3.78850501
14Infertility (HP:0000789)3.60662467
15Pancreatic fibrosis (HP:0100732)2.83330729
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78994016
17Abnormality of the nasal mucosa (HP:0000433)2.67384225
18Occipital encephalocele (HP:0002085)2.67031219
19Chromsome breakage (HP:0040012)2.62749376
20True hermaphroditism (HP:0010459)2.48688068
21Nephronophthisis (HP:0000090)2.37653224
22Recurrent sinusitis (HP:0011108)2.35334428
23Pancreatic cysts (HP:0001737)2.31306009
24Chronic hepatic failure (HP:0100626)2.29373490
25Atelectasis (HP:0100750)2.28757898
26Duodenal stenosis (HP:0100867)2.23877098
27Small intestinal stenosis (HP:0012848)2.23877098
28Recurrent otitis media (HP:0000403)2.21372054
29Bronchitis (HP:0012387)2.18230071
30Molar tooth sign on MRI (HP:0002419)2.16137785
31Abnormality of midbrain morphology (HP:0002418)2.16137785
32Preaxial hand polydactyly (HP:0001177)2.13216274
33Bell-shaped thorax (HP:0001591)2.11982127
34Median cleft lip (HP:0000161)2.10864802
35Postaxial foot polydactyly (HP:0001830)2.10298063
36Cystic liver disease (HP:0006706)2.10190707
37Oculomotor apraxia (HP:0000657)2.07338247
38Microvesicular hepatic steatosis (HP:0001414)2.07218578
39Tubulointerstitial abnormality (HP:0001969)2.06717169
40Sloping forehead (HP:0000340)2.05151719
41Meckel diverticulum (HP:0002245)2.04337478
42Facial cleft (HP:0002006)2.02580868
43High anterior hairline (HP:0009890)2.00771994
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.00316392
45Abnormality of the ileum (HP:0001549)1.99020651
46Abnormality of the preputium (HP:0100587)1.97886420
47Abnormal lung lobation (HP:0002101)1.97770657
48Abnormality of the lower motor neuron (HP:0002366)1.94940050
49Degeneration of anterior horn cells (HP:0002398)1.93308228
50Abnormality of the anterior horn cell (HP:0006802)1.93308228
51Medial flaring of the eyebrow (HP:0010747)1.92625953
52Upper motor neuron abnormality (HP:0002127)1.88411511
53Abnormality of the renal medulla (HP:0100957)1.87900632
54Male pseudohermaphroditism (HP:0000037)1.87651309
55Chronic sinusitis (HP:0011109)1.86052165
56Birth length less than 3rd percentile (HP:0003561)1.85488200
57Anencephaly (HP:0002323)1.84696227
58Sclerocornea (HP:0000647)1.84238231
59Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83595687
60Nephroblastoma (Wilms tumor) (HP:0002667)1.83516663
61Abnormality of chromosome stability (HP:0003220)1.83169741
62Azoospermia (HP:0000027)1.82882567
63Congenital primary aphakia (HP:0007707)1.80433008
64Aplasia/Hypoplasia of the uvula (HP:0010293)1.79104281
65Nephrogenic diabetes insipidus (HP:0009806)1.73085291
66Abnormality of the duodenum (HP:0002246)1.73014993
67Abdominal situs inversus (HP:0003363)1.71338574
68Abnormality of abdominal situs (HP:0011620)1.71338574
69Embryonal renal neoplasm (HP:0011794)1.68896385
70Abnormality of the labia minora (HP:0012880)1.67830700
71Shoulder girdle muscle weakness (HP:0003547)1.66976037
72Increased nuchal translucency (HP:0010880)1.66751733
73Abnormal spermatogenesis (HP:0008669)1.66265935
74Abnormal gallbladder physiology (HP:0012438)1.65808362
75Cholecystitis (HP:0001082)1.65808362
76Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65134589
77Hand muscle atrophy (HP:0009130)1.64719904
78CNS hypomyelination (HP:0003429)1.63472178
79Poor coordination (HP:0002370)1.63147635
80Gait imbalance (HP:0002141)1.62637683
81Abnormality of glycolysis (HP:0004366)1.62496057
82Proximal placement of thumb (HP:0009623)1.61218615
83Hyperactive renin-angiotensin system (HP:0000841)1.58187856
84Broad distal phalanx of finger (HP:0009836)1.57743560
85Ependymoma (HP:0002888)1.57365696
86Septate vagina (HP:0001153)1.56632421
87Aplasia/Hypoplasia of the earlobes (HP:0009906)1.54266984
88Absent epiphyses (HP:0010577)1.52713352
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52713352
90Squamous cell carcinoma (HP:0002860)1.48635269
91Carpal bone hypoplasia (HP:0001498)1.47796822
92Self-mutilation (HP:0000742)1.47181407
93Optic nerve coloboma (HP:0000588)1.47084231
94Short nail (HP:0001799)1.46867940
95Myelodysplasia (HP:0002863)1.45665776
96Amyotrophic lateral sclerosis (HP:0007354)1.45133599
97Poikiloderma (HP:0001029)1.44843242
98Congenital hepatic fibrosis (HP:0002612)1.43542097
99Facial hemangioma (HP:0000329)1.43520869
100Multicystic kidney dysplasia (HP:0000003)1.43478023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK43.88865488
2TTK3.86699967
3BUB13.37541919
4PNCK3.29211674
5MAPK152.88914272
6MST42.68414555
7ZAK2.68133781
8TSSK62.65966353
9WEE12.65327372
10STK162.59346185
11SRPK12.39042804
12CDC72.38957493
13BRSK22.36715949
14TRIM282.31375192
15NEK12.29781685
16BCR2.17122611
17BRD42.11598245
18EPHA22.07696090
19PLK11.99521862
20MAP4K21.96786029
21EIF2AK11.86631389
22EIF2AK31.78981662
23NME11.75798896
24PBK1.51175543
25AURKA1.50180556
26MST1R1.48680669
27CAMK1G1.47593227
28CHEK21.45694648
29ATR1.44388529
30CDK191.41404882
31BRSK11.40789882
32AKT31.36549957
33PLK31.30390473
34CHEK11.28538960
35PASK1.22870177
36PDK21.21499568
37NEK21.20956798
38CDK121.20706153
39CCNB11.20349346
40AURKB1.15239414
41CDK71.09073690
42NEK61.08697097
43MET1.01686692
44MKNK20.99710883
45MAP3K20.92974378
46TLK10.92167262
47MAP3K120.91238018
48ATM0.89569002
49STK38L0.82899893
50CDK10.79492049
51BRAF0.78974565
52PRKCI0.78167561
53CDK80.78073569
54MKNK10.75170654
55BMPR1B0.72227929
56CDK20.71529237
57VRK10.69971374
58MAP3K100.68849359
59MAP3K80.68733700
60CDK60.67648137
61EEF2K0.67180067
62PLK20.62186035
63RPS6KB20.61726980
64MUSK0.61328046
65CDK40.60482385
66SMG10.59836606
67MELK0.59757712
68DYRK30.59382688
69CLK10.57742446
70STK100.55649668
71ERBB30.55582400
72CDK30.54368554
73CAMK1D0.51271545
74MAP3K50.50640538
75TAF10.49573164
76CSNK1E0.48223581
77STK30.47576534
78LATS10.45864492
79NEK90.45444737
80KSR10.44649858
81VRK20.44359471
82STK380.44298473
83CDK90.43325558
84EIF2AK20.41236324
85PIM20.40275519
86CSNK2A20.40264901
87PTK2B0.37464804
88MTOR0.35461508
89GSK3B0.34864557
90MAPKAPK50.34231575
91STK40.34097964
92PAK10.33085764
93MAPK140.32039879
94PRKDC0.31958641
95CSNK2A10.30808305
96RPS6KA10.28426982
97RPS6KB10.27490591
98NME20.27202804
99TESK10.26033104
100AKT20.23506291

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.11549711
2Mismatch repair_Homo sapiens_hsa034303.74067823
3Base excision repair_Homo sapiens_hsa034103.43000618
4Cell cycle_Homo sapiens_hsa041103.09625171
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08882285
6RNA transport_Homo sapiens_hsa030133.02479146
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82659163
8Non-homologous end-joining_Homo sapiens_hsa034502.63082822
9Fanconi anemia pathway_Homo sapiens_hsa034602.62704135
10Basal transcription factors_Homo sapiens_hsa030222.57062414
11Homologous recombination_Homo sapiens_hsa034402.47886246
12Nucleotide excision repair_Homo sapiens_hsa034202.45382594
13Spliceosome_Homo sapiens_hsa030402.41327628
14RNA polymerase_Homo sapiens_hsa030202.25360382
15Proteasome_Homo sapiens_hsa030502.00569086
16RNA degradation_Homo sapiens_hsa030181.89514337
17mRNA surveillance pathway_Homo sapiens_hsa030151.86200484
18Pyrimidine metabolism_Homo sapiens_hsa002401.85643717
19Oocyte meiosis_Homo sapiens_hsa041141.72209523
20p53 signaling pathway_Homo sapiens_hsa041151.64290697
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63753258
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.60349040
23One carbon pool by folate_Homo sapiens_hsa006701.57473408
24beta-Alanine metabolism_Homo sapiens_hsa004101.53435119
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48374746
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46196301
27Huntingtons disease_Homo sapiens_hsa050161.40793392
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.32380107
29Glutathione metabolism_Homo sapiens_hsa004801.22467683
30Steroid biosynthesis_Homo sapiens_hsa001001.20839020
31Protein export_Homo sapiens_hsa030601.20236551
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20119074
33Purine metabolism_Homo sapiens_hsa002301.16166633
34Biosynthesis of amino acids_Homo sapiens_hsa012301.16007854
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12422884
36Phenylalanine metabolism_Homo sapiens_hsa003601.09710286
37Pyruvate metabolism_Homo sapiens_hsa006201.01499593
38Ribosome_Homo sapiens_hsa030100.98273465
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93070314
40Sulfur relay system_Homo sapiens_hsa041220.90967258
41Selenocompound metabolism_Homo sapiens_hsa004500.89992660
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88982283
43Regulation of autophagy_Homo sapiens_hsa041400.85815298
44N-Glycan biosynthesis_Homo sapiens_hsa005100.83397031
45Propanoate metabolism_Homo sapiens_hsa006400.83174267
46Lysine degradation_Homo sapiens_hsa003100.80250654
47Circadian rhythm_Homo sapiens_hsa047100.79778413
48Fatty acid biosynthesis_Homo sapiens_hsa000610.76282406
49Tyrosine metabolism_Homo sapiens_hsa003500.74609280
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69447089
51Sphingolipid metabolism_Homo sapiens_hsa006000.68789862
52Prostate cancer_Homo sapiens_hsa052150.68061438
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66857299
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.63976447
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63875468
56Chemical carcinogenesis_Homo sapiens_hsa052040.63433781
57Viral carcinogenesis_Homo sapiens_hsa052030.63264143
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63005675
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61482395
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60629183
61Folate biosynthesis_Homo sapiens_hsa007900.59525696
62Peroxisome_Homo sapiens_hsa041460.57863778
63mTOR signaling pathway_Homo sapiens_hsa041500.56394988
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56211743
65Carbon metabolism_Homo sapiens_hsa012000.55316664
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53463855
67Alcoholism_Homo sapiens_hsa050340.51596550
68Epstein-Barr virus infection_Homo sapiens_hsa051690.49357524
69Metabolic pathways_Homo sapiens_hsa011000.47796307
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46475279
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45961743
72Arginine biosynthesis_Homo sapiens_hsa002200.45242202
73TGF-beta signaling pathway_Homo sapiens_hsa043500.44309136
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40100234
75Pentose phosphate pathway_Homo sapiens_hsa000300.39407796
76Endometrial cancer_Homo sapiens_hsa052130.36084326
77Hippo signaling pathway_Homo sapiens_hsa043900.34714613
78Systemic lupus erythematosus_Homo sapiens_hsa053220.34198635
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32611283
80Colorectal cancer_Homo sapiens_hsa052100.32255203
81Adherens junction_Homo sapiens_hsa045200.31725649
82Hedgehog signaling pathway_Homo sapiens_hsa043400.30839169
83MicroRNAs in cancer_Homo sapiens_hsa052060.30235628
84Histidine metabolism_Homo sapiens_hsa003400.29246539
85Tight junction_Homo sapiens_hsa045300.28939250
86Non-small cell lung cancer_Homo sapiens_hsa052230.26034573
87Small cell lung cancer_Homo sapiens_hsa052220.26034208
88Retinol metabolism_Homo sapiens_hsa008300.25062643
89Thyroid cancer_Homo sapiens_hsa052160.23935763
90Apoptosis_Homo sapiens_hsa042100.23116629
91Fatty acid metabolism_Homo sapiens_hsa012120.22859841
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22764333
93Inositol phosphate metabolism_Homo sapiens_hsa005620.22421275
94FoxO signaling pathway_Homo sapiens_hsa040680.21926272
95Nitrogen metabolism_Homo sapiens_hsa009100.21451082
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21004298
97Caffeine metabolism_Homo sapiens_hsa002320.20337936
98Pancreatic cancer_Homo sapiens_hsa052120.20310024
99Dorso-ventral axis formation_Homo sapiens_hsa043200.19254652
100Fatty acid degradation_Homo sapiens_hsa000710.19094944

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