ZNF474

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)7.92702293
2left/right pattern formation (GO:0060972)7.79899814
3intraciliary transport (GO:0042073)6.98866836
4ventricular system development (GO:0021591)6.81370771
5left/right axis specification (GO:0070986)6.45240983
6cilium organization (GO:0044782)6.40356288
7cilium assembly (GO:0042384)6.24121359
8microtubule bundle formation (GO:0001578)5.72513232
9cilium morphogenesis (GO:0060271)5.40896572
10lung epithelium development (GO:0060428)5.32156668
11cellular component assembly involved in morphogenesis (GO:0010927)4.91142565
12protein localization to cilium (GO:0061512)4.90779945
13regulation of microtubule-based movement (GO:0060632)4.70632839
14microtubule-based movement (GO:0007018)4.57011933
15primary alcohol catabolic process (GO:0034310)4.52493368
16retinal rod cell development (GO:0046548)4.42245092
17cell projection assembly (GO:0030031)4.33268906
18smoothened signaling pathway (GO:0007224)3.98706829
19nonmotile primary cilium assembly (GO:0035058)3.90643402
20centriole assembly (GO:0098534)3.90369958
21vitamin transmembrane transport (GO:0035461)3.88712938
22diterpenoid biosynthetic process (GO:0016102)3.77721391
23nucleoside diphosphate phosphorylation (GO:0006165)3.70912567
24determination of left/right symmetry (GO:0007368)3.69333907
25response to xenobiotic stimulus (GO:0009410)3.68585309
26lateral ventricle development (GO:0021670)3.65362831
27terpenoid biosynthetic process (GO:0016114)3.64617120
28determination of bilateral symmetry (GO:0009855)3.61879716
29ethanol metabolic process (GO:0006067)3.56978629
30specification of symmetry (GO:0009799)3.54797907
31retinal cone cell development (GO:0046549)3.52496409
32positive regulation of oligodendrocyte differentiation (GO:0048714)3.49149640
33positive regulation of smoothened signaling pathway (GO:0045880)3.48827758
34establishment of tissue polarity (GO:0007164)3.47224407
35establishment of planar polarity (GO:0001736)3.47224407
36microtubule depolymerization (GO:0007019)3.35748722
37regulation of interleukin-5 production (GO:0032674)3.30207773
38lateral sprouting from an epithelium (GO:0060601)3.24805588
39sperm motility (GO:0030317)3.20356094
40sperm capacitation (GO:0048240)3.18369346
41neuronal stem cell maintenance (GO:0097150)3.12115753
42somite development (GO:0061053)3.11186793
43lung lobe morphogenesis (GO:0060463)3.10183209
44limb bud formation (GO:0060174)3.10106380
45neuron projection extension involved in neuron projection guidance (GO:1902284)3.04946325
46axon extension involved in axon guidance (GO:0048846)3.04946325
47glomerular epithelial cell development (GO:0072310)3.02607043
48heart looping (GO:0001947)3.02241141
49renal system development (GO:0072001)2.98470908
50pyrimidine-containing compound transmembrane transport (GO:0072531)2.97889711
51one-carbon compound transport (GO:0019755)2.95494132
52negative regulation of B cell mediated immunity (GO:0002713)2.94122813
53negative regulation of immunoglobulin mediated immune response (GO:0002890)2.94122813
54negative regulation of oligodendrocyte differentiation (GO:0048715)2.93673428
55photoreceptor cell maintenance (GO:0045494)2.91080320
56dorsal/ventral neural tube patterning (GO:0021904)2.90929765
57negative regulation of humoral immune response (GO:0002921)2.85603666
58cytoplasmic microtubule organization (GO:0031122)2.85292379
59regulation of oligodendrocyte differentiation (GO:0048713)2.85217522
60negative regulation of T cell differentiation in thymus (GO:0033085)2.83515227
61regulation of smoothened signaling pathway (GO:0008589)2.81017226
62retinoic acid metabolic process (GO:0042573)2.79625153
63negative regulation of axon guidance (GO:1902668)2.77216487
64microtubule polymerization or depolymerization (GO:0031109)2.76873986
65centriole replication (GO:0007099)2.76188749
66multicellular organismal aging (GO:0010259)2.75849132
67negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.73944455
68embryonic heart tube morphogenesis (GO:0003143)2.73668254
69cell proliferation involved in metanephros development (GO:0072203)2.69293467
70regulation of interleukin-13 production (GO:0032656)2.68512027
71organelle assembly (GO:0070925)2.66083758
72tolerance induction (GO:0002507)2.63680944
73microtubule-based process (GO:0007017)2.62596914
74establishment of monopolar cell polarity (GO:0061162)2.61339502
75establishment or maintenance of monopolar cell polarity (GO:0061339)2.61339502
76establishment of apical/basal cell polarity (GO:0035089)2.60221215
77carnitine metabolic process (GO:0009437)2.55973357
78ethanol oxidation (GO:0006069)2.55678460
79aldehyde catabolic process (GO:0046185)2.51977412
80glutathione derivative metabolic process (GO:1901685)2.48072988
81glutathione derivative biosynthetic process (GO:1901687)2.48072988
82astrocyte differentiation (GO:0048708)2.47372140
83eye photoreceptor cell differentiation (GO:0001754)2.47223231
84photoreceptor cell differentiation (GO:0046530)2.47223231
85protein polyglutamylation (GO:0018095)2.45779434
86DNA integration (GO:0015074)2.43698834
87exogenous drug catabolic process (GO:0042738)2.42265298
88neuroblast proliferation (GO:0007405)2.42081520
89auditory receptor cell differentiation (GO:0042491)2.41498655
90spinal cord association neuron differentiation (GO:0021527)2.38093405
91spinal cord motor neuron differentiation (GO:0021522)2.34429398
92cell differentiation in spinal cord (GO:0021515)2.30663142
93photoreceptor cell development (GO:0042461)2.29712344
94axonemal dynein complex assembly (GO:0070286)18.3456742
95cilium or flagellum-dependent cell motility (GO:0001539)17.2206769
96cilium movement (GO:0003341)15.0199154
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.0855037
98epithelial cilium movement (GO:0003351)13.0333935
99motile cilium assembly (GO:0044458)12.6490436
100axoneme assembly (GO:0035082)10.0077553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.12071415
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73821289
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.43138516
4PIAS1_25552417_ChIP-Seq_VCAP_Human2.42033206
5DROSHA_22980978_ChIP-Seq_HELA_Human2.22754109
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13395336
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04709292
8VDR_22108803_ChIP-Seq_LS180_Human1.95293348
9* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.93622737
10POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93079763
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90066967
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84010671
13CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79215292
14TP53_18474530_ChIP-ChIP_U2OS_Human1.78145670
15TAF15_26573619_Chip-Seq_HEK293_Human1.78078122
16SMAD4_21799915_ChIP-Seq_A2780_Human1.75421259
17* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68644621
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67853727
19IGF1R_20145208_ChIP-Seq_DFB_Human1.66017335
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65891204
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65055458
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63094875
23EWS_26573619_Chip-Seq_HEK293_Human1.58790649
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58750121
25CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54424154
26ZNF274_21170338_ChIP-Seq_K562_Hela1.53881269
27AHR_22903824_ChIP-Seq_MCF-7_Human1.53207058
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52572066
29P300_19829295_ChIP-Seq_ESCs_Human1.50801666
30FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48530972
31AR_21572438_ChIP-Seq_LNCaP_Human1.44959022
32FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.43612198
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42756327
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42687456
35FUS_26573619_Chip-Seq_HEK293_Human1.41083016
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.41008089
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.40108588
38TCF4_22108803_ChIP-Seq_LS180_Human1.39642180
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38598590
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.36884203
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.34251385
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33828596
43STAT3_23295773_ChIP-Seq_U87_Human1.31427499
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28421127
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27354350
46ER_23166858_ChIP-Seq_MCF-7_Human1.26350043
47TP53_16413492_ChIP-PET_HCT116_Human1.26106041
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25612227
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24499677
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24202537
51CBP_20019798_ChIP-Seq_JUKART_Human1.23631697
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23631697
53GBX2_23144817_ChIP-Seq_PC3_Human1.22594747
54RUNX2_22187159_ChIP-Seq_PCA_Human1.21353051
55* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21339072
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20927999
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.20012091
58AR_20517297_ChIP-Seq_VCAP_Human1.19091367
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17820420
60AR_25329375_ChIP-Seq_VCAP_Human1.17570684
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17427166
62BCAT_22108803_ChIP-Seq_LS180_Human1.17279822
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17246408
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16447793
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16447793
66* TP63_23658742_ChIP-Seq_EP156T_Human1.15261466
67PHF8_20622853_ChIP-Seq_HELA_Human1.13930654
68ETV1_20927104_ChIP-Seq_GIST48_Human1.13877689
69TBL1_22424771_ChIP-Seq_293T_Human1.12835609
70RNF2_27304074_Chip-Seq_NSC_Mouse1.11989279
71PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10720789
72* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10002031
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.09783517
74FOXA1_25552417_ChIP-Seq_VCAP_Human1.09424444
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.09200547
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08868706
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08820845
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08389435
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07804452
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07804452
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06767684
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.06576090
83TCF4_23295773_ChIP-Seq_U87_Human1.06536361
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.05030959
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04105142
86CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03894503
87NFYA_21822215_ChIP-Seq_K562_Human1.03430591
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02284112
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.00843654
90SMRT_27268052_Chip-Seq_Bcells_Human1.00203080
91NFYB_21822215_ChIP-Seq_K562_Human1.00030405
92SALL1_21062744_ChIP-ChIP_HESCs_Human0.99440424
93ESR1_21235772_ChIP-Seq_MCF-7_Human0.98600397
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97978980
95CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95468351
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94452322
97SOX2_19829295_ChIP-Seq_ESCs_Human0.94134144
98NANOG_19829295_ChIP-Seq_ESCs_Human0.94134144
99RBPJ_21746931_ChIP-Seq_IB4_Human0.93848090
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.93805532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology7.67433507
2MP0003283_abnormal_digestive_organ3.97986430
3MP0001984_abnormal_olfaction3.74065571
4MP0008875_abnormal_xenobiotic_pharmacok3.68066942
5MP0008789_abnormal_olfactory_epithelium3.55767725
6MP0004133_heterotaxia3.35693416
7MP0002282_abnormal_trachea_morphology3.06186840
8MP0002638_abnormal_pupillary_reflex2.97989205
9MP0000383_abnormal_hair_follicle2.92901566
10MP0002234_abnormal_pharynx_morphology2.87791551
11MP0000566_synostosis2.71894948
12MP0005623_abnormal_meninges_morphology2.71529238
13MP0005394_taste/olfaction_phenotype2.63593594
14MP0005499_abnormal_olfactory_system2.63593594
15MP0002132_abnormal_respiratory_system2.46695187
16MP0002102_abnormal_ear_morphology2.37752206
17MP0009053_abnormal_anal_canal2.29261133
18MP0010678_abnormal_skin_adnexa2.20980281
19MP0005171_absent_coat_pigmentation2.07000191
20MP0003136_yellow_coat_color2.06517453
21MP0004043_abnormal_pH_regulation1.94203884
22MP0001293_anophthalmia1.90471446
23MP0005253_abnormal_eye_physiology1.84273799
24MP0010030_abnormal_orbit_morphology1.81795142
25MP0002277_abnormal_respiratory_mucosa1.80723877
26MP0005248_abnormal_Harderian_gland1.73656610
27MP0002233_abnormal_nose_morphology1.69657437
28MP0001346_abnormal_lacrimal_gland1.60562504
29MP0003938_abnormal_ear_development1.57014484
30MP0001529_abnormal_vocalization1.56866466
31MP0000026_abnormal_inner_ear1.47467923
32MP0006072_abnormal_retinal_apoptosis1.36115898
33MP0005391_vision/eye_phenotype1.34371028
34MP0005083_abnormal_biliary_tract1.28701179
35MP0003937_abnormal_limbs/digits/tail_de1.27919730
36MP0005551_abnormal_eye_electrophysiolog1.23411793
37MP0002928_abnormal_bile_duct1.22316492
38MP0009780_abnormal_chondrocyte_physiolo1.21250904
39MP0002160_abnormal_reproductive_system1.21076725
40MP0002249_abnormal_larynx_morphology1.19847486
41MP0000778_abnormal_nervous_system1.17878039
42MP0000049_abnormal_middle_ear1.15742419
43MP0002734_abnormal_mechanical_nocicepti1.13846465
44MP0003890_abnormal_embryonic-extraembry1.12662255
45MP0001485_abnormal_pinna_reflex1.11304648
46MP0004019_abnormal_vitamin_homeostasis1.10147228
47MP0005195_abnormal_posterior_eye1.05397432
48MP0003878_abnormal_ear_physiology1.02651807
49MP0005377_hearing/vestibular/ear_phenot1.02651807
50MP0002751_abnormal_autonomic_nervous1.02650919
51MP0002092_abnormal_eye_morphology1.00575556
52MP0000631_abnormal_neuroendocrine_gland0.99258923
53MP0006292_abnormal_olfactory_placode0.98549916
54MP0005085_abnormal_gallbladder_physiolo0.97130409
55MP0000955_abnormal_spinal_cord0.97008950
56MP0004885_abnormal_endolymph0.89065768
57MP0000613_abnormal_salivary_gland0.88773224
58MP0001486_abnormal_startle_reflex0.88374193
59MP0000467_abnormal_esophagus_morphology0.87001719
60MP0001299_abnormal_eye_distance/0.86145866
61MP0002938_white_spotting0.80905393
62MP0002752_abnormal_somatic_nervous0.79771970
63MP0002116_abnormal_craniofacial_bone0.78765009
64MP0003861_abnormal_nervous_system0.78574331
65MP0009046_muscle_twitch0.77729059
66MP0002909_abnormal_adrenal_gland0.74017118
67MP0001286_abnormal_eye_development0.73086665
68MP0002084_abnormal_developmental_patter0.72732001
69MP0002168_other_aberrant_phenotype0.71842883
70MP0002090_abnormal_vision0.71501022
71MP0006276_abnormal_autonomic_nervous0.71307287
72MP0008961_abnormal_basal_metabolism0.70252689
73MP0003942_abnormal_urinary_system0.70060019
74MP0000534_abnormal_ureter_morphology0.69811373
75MP0005220_abnormal_exocrine_pancreas0.69420900
76MP0006054_spinal_hemorrhage0.69252943
77MP0002152_abnormal_brain_morphology0.68881740
78MP0002882_abnormal_neuron_morphology0.68558321
79MP0003698_abnormal_male_reproductive0.67497391
80MP0001963_abnormal_hearing_physiology0.66663042
81MP0002572_abnormal_emotion/affect_behav0.66519249
82MP0000678_abnormal_parathyroid_gland0.64692786
83MP0003755_abnormal_palate_morphology0.62811644
84MP0001324_abnormal_eye_pigmentation0.62327013
85MP0005503_abnormal_tendon_morphology0.62178234
86MP0001765_abnormal_ion_homeostasis0.62031040
87MP0005187_abnormal_penis_morphology0.61382695
88MP0001270_distended_abdomen0.60823767
89MP0002557_abnormal_social/conspecific_i0.60388830
90MP0002067_abnormal_sensory_capabilities0.59485436
91MP0008995_early_reproductive_senescence0.59245359
92MP0002932_abnormal_joint_morphology0.58658641
93MP0002098_abnormal_vibrissa_morphology0.57537605
94MP0000681_abnormal_thyroid_gland0.55672438
95MP0003119_abnormal_digestive_system0.55089014
96MP0001929_abnormal_gametogenesis0.53418900
97MP0002109_abnormal_limb_morphology0.52185761
98MP0001905_abnormal_dopamine_level0.52175244
99MP0003115_abnormal_respiratory_system0.51608087
100MP0009745_abnormal_behavioral_response0.51361433

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.38358321
2Chronic bronchitis (HP:0004469)6.60294414
3Bronchiectasis (HP:0002110)6.56586158
4Nasal polyposis (HP:0100582)5.75391991
5Abnormality of the nasal mucosa (HP:0000433)4.70516184
6True hermaphroditism (HP:0010459)4.47981043
7Pancreatic fibrosis (HP:0100732)4.33193444
8Occipital encephalocele (HP:0002085)4.10462117
9Chronic sinusitis (HP:0011109)3.94236606
10Recurrent sinusitis (HP:0011108)3.82160936
11Abnormality of midbrain morphology (HP:0002418)3.78607976
12Molar tooth sign on MRI (HP:0002419)3.78607976
13Bronchitis (HP:0012387)3.72101329
14Pancreatic cysts (HP:0001737)3.55425994
15Infertility (HP:0000789)3.45538348
16Chronic hepatic failure (HP:0100626)3.35316590
17Cystic liver disease (HP:0006706)3.28331411
18Nephronophthisis (HP:0000090)3.21435579
19Recurrent otitis media (HP:0000403)3.14298171
20Postaxial foot polydactyly (HP:0001830)3.10800754
21Atelectasis (HP:0100750)2.98058342
22Medial flaring of the eyebrow (HP:0010747)2.92574919
23Congenital primary aphakia (HP:0007707)2.83260579
24Gait imbalance (HP:0002141)2.78702832
25Chronic otitis media (HP:0000389)2.76769816
26Male infertility (HP:0003251)2.74157295
27Abnormality of the renal medulla (HP:0100957)2.69668239
28Tubulointerstitial nephritis (HP:0001970)2.67064629
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.66836858
30Nephrogenic diabetes insipidus (HP:0009806)2.54324739
31Anencephaly (HP:0002323)2.50781591
32Congenital hepatic fibrosis (HP:0002612)2.40791902
33Sclerocornea (HP:0000647)2.30888342
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28455548
35Postaxial hand polydactyly (HP:0001162)2.24651286
36Tubular atrophy (HP:0000092)2.13588613
37Preaxial hand polydactyly (HP:0001177)2.12919796
38Male pseudohermaphroditism (HP:0000037)2.09278279
39Hyperactive renin-angiotensin system (HP:0000841)2.03685852
40Poor coordination (HP:0002370)2.01748491
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.3441779
42Abnormal ciliary motility (HP:0012262)10.5250292
43Abnormal respiratory epithelium morphology (HP:0012253)10.4635852
44Abnormal respiratory motile cilium morphology (HP:0005938)10.4635852
45Dynein arm defect of respiratory motile cilia (HP:0012255)10.4149589
46Absent/shortened dynein arms (HP:0200106)10.4149589
47Abnormal respiratory motile cilium physiology (HP:0012261)10.3958010
48Vaginal atresia (HP:0000148)1.98422640
49Genital tract atresia (HP:0001827)1.97773980
50Oculomotor apraxia (HP:0000657)1.95602585
51Furrowed tongue (HP:0000221)1.88311880
52Abnormal rod and cone electroretinograms (HP:0008323)1.85254494
53Bell-shaped thorax (HP:0001591)1.76855693
54Tubulointerstitial abnormality (HP:0001969)1.76238846
55Recurrent bronchitis (HP:0002837)1.73968583
56Short nail (HP:0001799)1.71498087
57Bile duct proliferation (HP:0001408)1.65476507
58Abnormal biliary tract physiology (HP:0012439)1.65476507
59Median cleft lip (HP:0000161)1.64949761
60Specific learning disability (HP:0001328)1.63091231
61Abnormality of dentin (HP:0010299)1.59093584
62Nephropathy (HP:0000112)1.55784898
63Decreased central vision (HP:0007663)1.48058393
64Asplenia (HP:0001746)1.46782673
65Absent frontal sinuses (HP:0002688)1.46615211
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.45401632
67Aplasia/Hypoplasia of the lens (HP:0008063)1.44520455
68Supernumerary spleens (HP:0009799)1.42323264
69Anophthalmia (HP:0000528)1.40670441
70Broad foot (HP:0001769)1.36060379
71Anosmia (HP:0000458)1.35363565
72Aganglionic megacolon (HP:0002251)1.35135540
73Prominent nasal bridge (HP:0000426)1.35126431
74Narrow forehead (HP:0000341)1.33537285
75Renal dysplasia (HP:0000110)1.32819722
76Tubulointerstitial fibrosis (HP:0005576)1.30800671
77Retinitis pigmentosa (HP:0000510)1.29928939
78Renal salt wasting (HP:0000127)1.28886038
79Holoprosencephaly (HP:0001360)1.28589007
80Tented upper lip vermilion (HP:0010804)1.26466639
81Cone-rod dystrophy (HP:0000548)1.24366271
82Abnormal drinking behavior (HP:0030082)1.23358475
83Polydipsia (HP:0001959)1.23358475
84Decreased circulating renin level (HP:0003351)1.22783914
85Maternal diabetes (HP:0009800)1.22267036
86Stage 5 chronic kidney disease (HP:0003774)1.21471630
87Asthma (HP:0002099)1.19324776
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.18703747
89Short thorax (HP:0010306)1.18352413
90Decreased testicular size (HP:0008734)1.16307750
91Optic nerve coloboma (HP:0000588)1.16187305
92Bifid scrotum (HP:0000048)1.15717835
93Multicystic kidney dysplasia (HP:0000003)1.14695267
94Abnormality of the renal cortex (HP:0011035)1.11667320
95Narrow nasal bridge (HP:0000446)1.10873096
96Abnormality of the dental pulp (HP:0006479)1.10826271
97Iris coloboma (HP:0000612)1.09341250
98Vertebral arch anomaly (HP:0008438)1.08447397
99Taurodontia (HP:0000679)1.07638630
100Abnormality of permanent molar morphology (HP:0011071)1.07638630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.56486973
2MST44.33510114
3BCR3.74053503
4EPHA22.91054880
5STK242.63816729
6EPHA32.50561056
7MAP3K42.21985476
8PNCK2.02408593
9MAP4K21.84898530
10WNK31.71408685
11STK38L1.70467805
12ERBB31.69910440
13BMPR1B1.68223832
14EPHB21.57108558
15PTK2B1.55311728
16MAPKAPK31.52989432
17CASK1.47920888
18TRIM281.37852387
19NEK91.34796591
20NME11.32757063
21IRAK11.27627719
22ERBB21.17268598
23STK391.15070507
24CDK91.04994716
25CSNK1G21.04597184
26EPHA41.02028593
27PBK0.97907238
28CSNK1A1L0.95549148
29CDK80.93465256
30MAP2K70.92817295
31TSSK60.88952845
32DYRK1B0.88170198
33FER0.86694300
34CSNK1G30.86386325
35DYRK30.84537702
36LRRK20.81673196
37MET0.81602239
38CSNK1G10.79031578
39PIM20.76941459
40FRK0.73791222
41KSR10.70676437
42MAP3K20.70482568
43GRK10.68821793
44EPHB10.68666890
45MAPK130.66203361
46RPS6KA40.64471338
47OXSR10.63536601
48PAK30.62700469
49STK100.62110732
50WNK40.61752686
51TTK0.61466405
52TGFBR10.59980787
53EIF2AK30.58907151
54ACVR1B0.57174970
55INSRR0.55142271
56MAP3K70.55125258
57NTRK20.54211550
58PRKCI0.53842295
59STK160.53097983
60NEK60.51767434
61BCKDK0.51587652
62ROCK20.50785867
63MST1R0.50612301
64DYRK1A0.49714997
65ADRBK20.49348729
66CHUK0.47414149
67PRKCE0.46234152
68MARK20.46017670
69PAK60.44676064
70AURKA0.43660113
71CAMKK20.43541482
72CAMK2A0.43504517
73LATS10.41733082
74TNIK0.41310298
75SGK4940.40160068
76SGK2230.40160068
77STK30.39704944
78DYRK20.39496336
79CAMK2G0.38783193
80MKNK10.37350227
81CDK60.36857163
82CSK0.36764163
83PINK10.35441182
84IRAK20.35244277
85ICK0.34055897
86AKT20.33964351
87TLK10.33853266
88MAP2K40.33579412
89PRKACA0.30479504
90MUSK0.30417027
91WEE10.30190790
92CSNK1A10.30165379
93EIF2AK10.29027444
94ADRBK10.28889295
95PLK20.27072701
96ROCK10.25976384
97PRKCQ0.25122360
98SGK20.24796988
99MAP3K50.24257971
100EGFR0.23306544

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.16236511
2Phenylalanine metabolism_Homo sapiens_hsa003603.68522131
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.48603365
4Chemical carcinogenesis_Homo sapiens_hsa052043.41617661
5Histidine metabolism_Homo sapiens_hsa003403.37235748
6Huntingtons disease_Homo sapiens_hsa050163.16307221
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93400705
8beta-Alanine metabolism_Homo sapiens_hsa004102.68210062
9Tyrosine metabolism_Homo sapiens_hsa003502.55736805
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.49176372
11Glutathione metabolism_Homo sapiens_hsa004802.25992495
12Basal cell carcinoma_Homo sapiens_hsa052172.17635238
13Steroid biosynthesis_Homo sapiens_hsa001002.09553210
14Caffeine metabolism_Homo sapiens_hsa002321.92107323
15Hedgehog signaling pathway_Homo sapiens_hsa043401.90626675
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87664904
17Propanoate metabolism_Homo sapiens_hsa006401.86574171
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.86172094
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82155017
20Peroxisome_Homo sapiens_hsa041461.71690553
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68434881
22Linoleic acid metabolism_Homo sapiens_hsa005911.67440792
23Retinol metabolism_Homo sapiens_hsa008301.66959618
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58420410
25Protein export_Homo sapiens_hsa030601.49234511
26ABC transporters_Homo sapiens_hsa020101.44003564
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43279759
28Butanoate metabolism_Homo sapiens_hsa006501.42498941
29Notch signaling pathway_Homo sapiens_hsa043301.34599875
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29562236
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.28693277
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20727946
33Circadian rhythm_Homo sapiens_hsa047101.17002834
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.12530813
35Fatty acid degradation_Homo sapiens_hsa000711.11685148
36Sphingolipid metabolism_Homo sapiens_hsa006001.09077538
37Tight junction_Homo sapiens_hsa045301.07768660
38Phototransduction_Homo sapiens_hsa047441.06682922
39Cocaine addiction_Homo sapiens_hsa050301.02780565
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97525390
41Hippo signaling pathway_Homo sapiens_hsa043900.95154229
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94066045
43Tryptophan metabolism_Homo sapiens_hsa003800.92757233
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91896096
45Nitrogen metabolism_Homo sapiens_hsa009100.91320991
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85357271
47Pyruvate metabolism_Homo sapiens_hsa006200.85034420
48Arginine and proline metabolism_Homo sapiens_hsa003300.79578972
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78767430
50Axon guidance_Homo sapiens_hsa043600.75855613
51Salivary secretion_Homo sapiens_hsa049700.75116457
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74950663
53Arachidonic acid metabolism_Homo sapiens_hsa005900.74479791
54PPAR signaling pathway_Homo sapiens_hsa033200.71081137
55Olfactory transduction_Homo sapiens_hsa047400.66488564
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65290081
57Oxidative phosphorylation_Homo sapiens_hsa001900.64440796
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63500759
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.60448630
60Metabolic pathways_Homo sapiens_hsa011000.59631362
61Adherens junction_Homo sapiens_hsa045200.59585939
62Nicotine addiction_Homo sapiens_hsa050330.57931337
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55786853
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52405545
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52266398
66Fatty acid elongation_Homo sapiens_hsa000620.51629185
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50182150
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49896845
69Cardiac muscle contraction_Homo sapiens_hsa042600.49363038
70Taste transduction_Homo sapiens_hsa047420.49241471
71Fatty acid metabolism_Homo sapiens_hsa012120.48756161
72Melanogenesis_Homo sapiens_hsa049160.44101827
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42685661
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39996584
75Parkinsons disease_Homo sapiens_hsa050120.39198888
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37893932
77Choline metabolism in cancer_Homo sapiens_hsa052310.35945835
78Starch and sucrose metabolism_Homo sapiens_hsa005000.33989776
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.33700383
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29946440
81Alzheimers disease_Homo sapiens_hsa050100.29436646
82TGF-beta signaling pathway_Homo sapiens_hsa043500.29393668
83Wnt signaling pathway_Homo sapiens_hsa043100.28269866
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.27373655
85Basal transcription factors_Homo sapiens_hsa030220.26532522
86Glycerolipid metabolism_Homo sapiens_hsa005610.25023460
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24720280
88Serotonergic synapse_Homo sapiens_hsa047260.22137739
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21548226
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21157181
91Dopaminergic synapse_Homo sapiens_hsa047280.20938715
92Alcoholism_Homo sapiens_hsa050340.20333298
93Amphetamine addiction_Homo sapiens_hsa050310.19095981
94cAMP signaling pathway_Homo sapiens_hsa040240.17145444
95Collecting duct acid secretion_Homo sapiens_hsa049660.16655259
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16084005
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15755929
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11785250
99Thyroid hormone synthesis_Homo sapiens_hsa049180.11114361
100Glutamatergic synapse_Homo sapiens_hsa047240.10800649

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