ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	5.56674632
2	chaperone-mediated protein complex assembly (GO:0051131)	5.39545299
3	multicellular organism reproduction (GO:0032504)	5.37442893
4	acrosome reaction (GO:0007340)	4.83930161
5	meiotic chromosome segregation (GO:0045132)	4.64805386
6	rRNA methylation (GO:0031167)	4.50254918
7	meiosis I (GO:0007127)	4.44632469
8	rRNA modification (GO:0000154)	4.40655078
9	protein targeting to Golgi (GO:0000042)	4.35457799
10	synapsis (GO:0007129)	4.28701634
11	establishment of protein localization to Golgi (GO:0072600)	4.24961571
12	male meiosis (GO:0007140)	4.14028513
13	piRNA metabolic process (GO:0034587)	4.12238481
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.97179643
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.97179643
16	fusion of sperm to egg plasma membrane (GO:0007342)	3.89357983
17	binding of sperm to zona pellucida (GO:0007339)	3.86620079
18	behavioral response to nicotine (GO:0035095)	3.80094897
19	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.77376792
20	sperm-egg recognition (GO:0035036)	3.69382427
21	DNA double-strand break processing (GO:0000729)	3.67808455
22	protein localization to Golgi apparatus (GO:0034067)	3.66220228
23	regulation of meiosis I (GO:0060631)	3.65580233
24	reproduction (GO:0000003)	3.65231926
25	positive regulation of catecholamine secretion (GO:0033605)	3.58020076
26	regulation of acrosome reaction (GO:0060046)	3.56667375
27	gonadal mesoderm development (GO:0007506)	3.50691029
28	positive regulation of prostaglandin secretion (GO:0032308)	3.36048453
29	protein polyglutamylation (GO:0018095)	3.35206666
30	calcium ion-dependent exocytosis (GO:0017156)	3.31138157
31	spermatid development (GO:0007286)	3.29500222
32	single fertilization (GO:0007338)	3.28782686
33	microtubule depolymerization (GO:0007019)	3.27918657
34	sperm motility (GO:0030317)	3.26704451
35	seminiferous tubule development (GO:0072520)	3.26099323
36	oocyte development (GO:0048599)	3.25159518
37	histone H2A monoubiquitination (GO:0035518)	3.19103948
38	resolution of meiotic recombination intermediates (GO:0000712)	3.12268769
39	cell-cell recognition (GO:0009988)	3.08042781
40	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	21.0113315
41	epithelial cilium movement (GO:0003351)	2.98972269
42	positive regulation of meiosis (GO:0045836)	2.96158478
43	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.95048230
44	heart contraction (GO:0060047)	2.95017638
45	heart process (GO:0003015)	2.95017638
46	regulation of female gonad development (GO:2000194)	2.94259923
47	plasma membrane fusion (GO:0045026)	2.93601597
48	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.90180239
49	positive regulation of meiotic cell cycle (GO:0051446)	2.89338597
50	regulation of glucokinase activity (GO:0033131)	2.88143995
51	regulation of hexokinase activity (GO:1903299)	2.88143995
52	microtubule polymerization or depolymerization (GO:0031109)	2.87131547
53	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.84586489
54	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.82058278
55	positive regulation of ligase activity (GO:0051351)	2.81222777
56	regulation of action potential (GO:0098900)	2.79771680
57	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.78514609
58	fertilization (GO:0009566)	2.78184444
59	retinal cone cell development (GO:0046549)	2.75991757
60	DNA catabolic process, exonucleolytic (GO:0000738)	2.75705054
61	histone mRNA metabolic process (GO:0008334)	2.74810895
62	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.73318907
63	histone H3-K9 demethylation (GO:0033169)	2.73141782
64	chromosome organization involved in meiosis (GO:0070192)	2.72397721
65	reciprocal meiotic recombination (GO:0007131)	2.72337386
66	reciprocal DNA recombination (GO:0035825)	2.72337386
67	regulation of prostaglandin secretion (GO:0032306)	2.72263591
68	proteasome assembly (GO:0043248)	2.70442686
69	exogenous drug catabolic process (GO:0042738)	2.70130150
70	protein localization to cilium (GO:0061512)	2.69490274
71	meiotic cell cycle process (GO:1903046)	2.69424243
72	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.68140340
73	meiotic nuclear division (GO:0007126)	2.67731830
74	termination of RNA polymerase III transcription (GO:0006386)	2.66916404
75	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.66916404
76	ribonucleoprotein complex disassembly (GO:0032988)	2.66885309
77	intra-S DNA damage checkpoint (GO:0031573)	2.66313656
78	DNA deamination (GO:0045006)	2.64816478
79	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.64643921
80	preassembly of GPI anchor in ER membrane (GO:0016254)	2.64310911
81	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.63115123
82	mitochondrial fission (GO:0000266)	2.62112772
83	spermatogenesis (GO:0007283)	2.61845029
84	male gamete generation (GO:0048232)	2.61162963
85	alkaloid metabolic process (GO:0009820)	2.60328684
86	protein K6-linked ubiquitination (GO:0085020)	2.56747994
87	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.56731433
88	gamete generation (GO:0007276)	2.55770921
89	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.54085282
90	regulation of cellular amino acid metabolic process (GO:0006521)	2.51956318
91	histone H2A ubiquitination (GO:0033522)	2.50790248
92	oxidative demethylation (GO:0070989)	2.49532736
93	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.49495708
94	negative regulation of ligase activity (GO:0051352)	2.49495708
95	transcription from mitochondrial promoter (GO:0006390)	2.49493151
96	meiotic cell cycle (GO:0051321)	2.49296692
97	autophagic vacuole assembly (GO:0000045)	2.46697986
98	protein-cofactor linkage (GO:0018065)	2.43933195
99	N-glycan processing (GO:0006491)	2.40369174
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	17.7648888

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.44102929
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.36479301
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75466428
4	VDR_22108803_ChIP-Seq_LS180_Human	3.48061783
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.28557931
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.26445189
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17202124
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60570834
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57952254
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.43552604
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.14311207
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12827156
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.12407321
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06997092
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92585282
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91751375
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.90434578
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88565285
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.85112098
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.81681543
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.71061688
22	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.64520124
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63024410
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.63023172
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62282153
26	RBPJ_21746931_ChIP-Seq_IB4_Human	1.61627141
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.61458084
28	ETV1_20927104_ChIP-Seq_GIST48_Human	1.60767555
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59886449
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.59288388
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.57492869
32	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.57195244
33	* ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.56832895
34	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.52292647
35	P300_19829295_ChIP-Seq_ESCs_Human	1.51406220
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.50615854
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.50062841
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44709797
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.42146152
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.39746838
41	FUS_26573619_Chip-Seq_HEK293_Human	1.39361215
42	NFYB_21822215_ChIP-Seq_K562_Human	1.36956704
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.36648984
44	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35996145
45	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.35169492
46	HOXB7_26014856_ChIP-Seq_BT474_Human	1.34845187
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34065259
48	PHF8_20622853_ChIP-Seq_HELA_Human	1.33509730
49	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32397082
50	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.30990301
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29782459
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.29652329
53	TBL1_22424771_ChIP-Seq_293T_Human	1.29233068
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26240267
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26240267
56	GBX2_23144817_ChIP-Seq_PC3_Human	1.23082547
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.21977223
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.21724268
59	EWS_26573619_Chip-Seq_HEK293_Human	1.21294107
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.21113490
61	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.20474567
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19915418
63	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.19914562
64	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.19173616
65	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.18805264
66	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.17353293
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.17242289
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17242289
69	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.16127464
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15397835
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15263135
72	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.14444064
73	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.14444064
74	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.14444064
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13994658
76	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.13934993
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13671684
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13480508
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.13331898
80	NCOR_22424771_ChIP-Seq_293T_Human	1.12044217
81	TTF2_22483619_ChIP-Seq_HELA_Human	1.11394675
82	AR_25329375_ChIP-Seq_VCAP_Human	1.11148949
83	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.10684494
84	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10040883
85	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.08570167
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06032424
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05742069
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05099329
89	GATA3_26560356_Chip-Seq_TH1_Human	1.03812200
90	HTT_18923047_ChIP-ChIP_STHdh_Human	1.03699755
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01611741
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01392674
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01392674
94	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.01032000
95	NFYA_21822215_ChIP-Seq_K562_Human	1.00222881
96	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00008072
97	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.99923602
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99806391
99	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99109541
100	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.99044102

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.35486047
2	MP0006292_abnormal_olfactory_placode	3.32835426
3	MP0005410_abnormal_fertilization	3.21136333
4	MP0008877_abnormal_DNA_methylation	2.80553961
5	MP0003646_muscle_fatigue	2.76211711
6	MP0005645_abnormal_hypothalamus_physiol	2.70419865
7	MP0001929_abnormal_gametogenesis	2.50803603
8	MP0003787_abnormal_imprinting	2.48638145
9	MP0010386_abnormal_urinary_bladder	2.46626641
10	MP0003718_maternal_effect	2.35658991
11	MP0001986_abnormal_taste_sensitivity	2.33383874
12	MP0006276_abnormal_autonomic_nervous	2.31889426
13	MP0005499_abnormal_olfactory_system	2.31559985
14	MP0005394_taste/olfaction_phenotype	2.31559985
15	MP0002210_abnormal_sex_determination	2.27672473
16	MP0008789_abnormal_olfactory_epithelium	2.15060213
17	MP0001968_abnormal_touch/_nociception	2.00760541
18	MP0008995_early_reproductive_senescence	2.00210929
19	MP0002102_abnormal_ear_morphology	1.99246185
20	MP0005423_abnormal_somatic_nervous	1.94874656
21	MP0003698_abnormal_male_reproductive	1.91545975
22	MP0003136_yellow_coat_color	1.79037233
23	MP0002638_abnormal_pupillary_reflex	1.77657910
24	MP0000569_abnormal_digit_pigmentation	1.73504209
25	MP0002160_abnormal_reproductive_system	1.71889432
26	MP0005389_reproductive_system_phenotype	1.70583808
27	MP0000653_abnormal_sex_gland	1.65414117
28	MP0004782_abnormal_surfactant_physiolog	1.64909900
29	MP0002272_abnormal_nervous_system	1.64013967
30	MP0008058_abnormal_DNA_repair	1.63678276
31	MP0008872_abnormal_physiological_respon	1.60503884
32	MP0001177_atelectasis	1.59484920
33	MP0001764_abnormal_homeostasis	1.57922067
34	MP0003806_abnormal_nucleotide_metabolis	1.57651816
35	MP0005379_endocrine/exocrine_gland_phen	1.56505606
36	MP0001145_abnormal_male_reproductive	1.56452503
37	MP0004142_abnormal_muscle_tone	1.49748485
38	MP0001529_abnormal_vocalization	1.49066480
39	MP0005451_abnormal_body_composition	1.46589572
40	MP0002735_abnormal_chemical_nociception	1.46245028
41	MP0004957_abnormal_blastocyst_morpholog	1.43603616
42	MP0006072_abnormal_retinal_apoptosis	1.42581102
43	MP0001919_abnormal_reproductive_system	1.38637674
44	MP0002736_abnormal_nociception_after	1.36316641
45	MP0003786_premature_aging	1.36251415
46	MP0005647_abnormal_sex_gland	1.35641551
47	MP0003693_abnormal_embryo_hatching	1.34133673
48	MP0001293_anophthalmia	1.33340624
49	MP0008875_abnormal_xenobiotic_pharmacok	1.29767285
50	MP0001119_abnormal_female_reproductive	1.28791702
51	MP0003123_paternal_imprinting	1.27798901
52	MP0005551_abnormal_eye_electrophysiolog	1.27322890
53	MP0003121_genomic_imprinting	1.26735698
54	MP0000372_irregular_coat_pigmentation	1.24995798
55	MP0002277_abnormal_respiratory_mucosa	1.24384178
56	MP0004145_abnormal_muscle_electrophysio	1.23939196
57	MP0001970_abnormal_pain_threshold	1.20549478
58	MP0000631_abnormal_neuroendocrine_gland	1.19644257
59	MP0002161_abnormal_fertility/fecundity	1.17606496
60	MP0001905_abnormal_dopamine_level	1.16098046
61	MP0003186_abnormal_redox_activity	1.15317936
62	MP0003195_calcinosis	1.13279220
63	MP0009745_abnormal_behavioral_response	1.12863824
64	MP0010094_abnormal_chromosome_stability	1.11974629
65	MP0002295_abnormal_pulmonary_circulatio	1.09772138
66	MP0004215_abnormal_myocardial_fiber	1.08317252
67	MP0000049_abnormal_middle_ear	1.07233441
68	MP0005253_abnormal_eye_physiology	1.03280534
69	MP0000427_abnormal_hair_cycle	1.00714846
70	MP0002095_abnormal_skin_pigmentation	0.99690889
71	MP0001486_abnormal_startle_reflex	0.99560863
72	MP0000778_abnormal_nervous_system	0.97027868
73	MP0000538_abnormal_urinary_bladder	0.96274789
74	MP0009046_muscle_twitch	0.95940394
75	MP0001440_abnormal_grooming_behavior	0.94490095
76	MP0002557_abnormal_social/conspecific_i	0.93627693
77	MP0002653_abnormal_ependyma_morphology	0.93325424
78	MP0002733_abnormal_thermal_nociception	0.91657155
79	MP0001984_abnormal_olfaction	0.90038080
80	MP0002067_abnormal_sensory_capabilities	0.86505323
81	MP0002163_abnormal_gland_morphology	0.84637366
82	MP0002254_reproductive_system_inflammat	0.82516602
83	MP0001485_abnormal_pinna_reflex	0.82388640
84	MP0003699_abnormal_female_reproductive	0.82089296
85	MP0002572_abnormal_emotion/affect_behav	0.81066636
86	MP0005075_abnormal_melanosome_morpholog	0.77818331
87	MP0005174_abnormal_tail_pigmentation	0.77723683
88	MP0008932_abnormal_embryonic_tissue	0.77604039
89	MP0005408_hypopigmentation	0.76614467
90	MP0001664_abnormal_digestion	0.76257702
91	MP0002734_abnormal_mechanical_nocicepti	0.76163701
92	MP0001756_abnormal_urination	0.74087234
93	MP0002837_dystrophic_cardiac_calcinosis	0.73675820
94	MP0006036_abnormal_mitochondrial_physio	0.71604658
95	MP0009379_abnormal_foot_pigmentation	0.71381791
96	MP0002822_catalepsy	0.69337880
97	MP0004742_abnormal_vestibular_system	0.66221827
98	MP0001963_abnormal_hearing_physiology	0.65433712
99	MP0003115_abnormal_respiratory_system	0.64359954
100	MP0000015_abnormal_ear_pigmentation	0.58769825

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Concave nail (HP:0001598)	4.58572559
2	Dyschromatopsia (HP:0007641)	3.26458487
3	Central scotoma (HP:0000603)	3.24669460
4	Scotoma (HP:0000575)	3.21450392
5	Hypophosphatemic rickets (HP:0004912)	3.21061488
6	Nephronophthisis (HP:0000090)	3.11562541
7	Abolished electroretinogram (ERG) (HP:0000550)	3.06577966
8	Severe visual impairment (HP:0001141)	2.99926236
9	Limb hypertonia (HP:0002509)	2.98766290
10	Abnormal rod and cone electroretinograms (HP:0008323)	2.96717028
11	Male infertility (HP:0003251)	2.95616950
12	Abnormality of midbrain morphology (HP:0002418)	2.92358275
13	Molar tooth sign on MRI (HP:0002419)	2.92358275
14	Tubulointerstitial nephritis (HP:0001970)	2.81742302
15	Methylmalonic acidemia (HP:0002912)	2.70524658
16	Hypoplasia of the fovea (HP:0007750)	2.70435865
17	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.70435865
18	Acute encephalopathy (HP:0006846)	2.65065684
19	Abnormality of the renal medulla (HP:0100957)	2.60382084
20	Abnormality of the fovea (HP:0000493)	2.59228729
21	Delayed CNS myelination (HP:0002188)	2.56750671
22	Congenital, generalized hypertrichosis (HP:0004540)	2.55473619
23	Medial flaring of the eyebrow (HP:0010747)	2.54743431
24	Mitochondrial inheritance (HP:0001427)	2.49647725
25	Increased CSF lactate (HP:0002490)	2.47966816
26	Attenuation of retinal blood vessels (HP:0007843)	2.43888730
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.43107968
28	Chronic hepatic failure (HP:0100626)	2.42921016
29	Absent/shortened dynein arms (HP:0200106)	2.40560406
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.40560406
31	Acute necrotizing encephalopathy (HP:0006965)	2.38642920
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36202829
33	Abdominal situs inversus (HP:0003363)	2.35418450
34	Abnormality of abdominal situs (HP:0011620)	2.35418450
35	Hyperglycinemia (HP:0002154)	2.34755023
36	Methylmalonic aciduria (HP:0012120)	2.31815978
37	Horizontal nystagmus (HP:0000666)	2.30252907
38	Male pseudohermaphroditism (HP:0000037)	2.27380154
39	Hyperphosphaturia (HP:0003109)	2.26629215
40	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.26167006
41	Pendular nystagmus (HP:0012043)	2.26010975
42	Carpal bone hypoplasia (HP:0001498)	2.23633050
43	Abnormality of vitamin B metabolism (HP:0004340)	2.23095946
44	Renal Fanconi syndrome (HP:0001994)	2.20948939
45	Pancreatic cysts (HP:0001737)	2.19141169
46	Increased hepatocellular lipid droplets (HP:0006565)	2.18545786
47	Constricted visual fields (HP:0001133)	2.14879880
48	Hepatocellular necrosis (HP:0001404)	2.14789525
49	Tubular atrophy (HP:0000092)	2.13310343
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.12575489
51	Abnormality of dental color (HP:0011073)	2.11385088
52	Horseshoe kidney (HP:0000085)	2.08032826
53	Rib fusion (HP:0000902)	2.07816967
54	Volvulus (HP:0002580)	2.04619170
55	Barrel-shaped chest (HP:0001552)	2.03464730
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03140617
57	Abnormality of alanine metabolism (HP:0010916)	2.03140617
58	Hyperalaninemia (HP:0003348)	2.03140617
59	Respiratory failure (HP:0002878)	2.03010489
60	Hepatic necrosis (HP:0002605)	2.02790992
61	Nephrogenic diabetes insipidus (HP:0009806)	2.02773285
62	3-Methylglutaconic aciduria (HP:0003535)	2.00886431
63	Febrile seizures (HP:0002373)	2.00847701
64	Lipid accumulation in hepatocytes (HP:0006561)	1.99446139
65	Abnormality of serum amino acid levels (HP:0003112)	1.99432920
66	Progressive macrocephaly (HP:0004481)	1.98025888
67	True hermaphroditism (HP:0010459)	1.96868884
68	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95770162
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95137793
70	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.95049705
71	Absent epiphyses (HP:0010577)	1.95049705
72	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.93858383
73	Septo-optic dysplasia (HP:0100842)	1.93623954
74	Optic disc pallor (HP:0000543)	1.93378095
75	Lactic acidosis (HP:0003128)	1.93222132
76	Hypoproteinemia (HP:0003075)	1.91976929
77	Congenital stationary night blindness (HP:0007642)	1.91868654
78	Pancreatic fibrosis (HP:0100732)	1.91730903
79	Increased serum lactate (HP:0002151)	1.91351850
80	Abnormality of macular pigmentation (HP:0008002)	1.90992395
81	Tubulointerstitial abnormality (HP:0001969)	1.90080596
82	Poor suck (HP:0002033)	1.88695261
83	Porencephaly (HP:0002132)	1.88529777
84	Median cleft lip (HP:0000161)	1.88009579
85	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86836154
86	Abnormal ciliary motility (HP:0012262)	1.85736988
87	Proximal tubulopathy (HP:0000114)	1.85179573
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84110607
89	Abnormal respiratory epithelium morphology (HP:0012253)	1.84110607
90	Woolly hair (HP:0002224)	1.82829462
91	Decreased central vision (HP:0007663)	1.81987306
92	Rhinitis (HP:0012384)	1.81922824
93	Congenital primary aphakia (HP:0007707)	1.81792509
94	Abnormal drinking behavior (HP:0030082)	1.81577916
95	Polydipsia (HP:0001959)	1.81577916
96	Glycosuria (HP:0003076)	1.79727887
97	Abnormality of urine glucose concentration (HP:0011016)	1.79727887
98	Abnormal number of incisors (HP:0011064)	1.79307416
99	Optic nerve hypoplasia (HP:0000609)	1.78524123
100	Birth length less than 3rd percentile (HP:0003561)	1.78104835

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	3.49691618
2	TRIM28	3.43617028
3	CASK	3.29317590
4	STK38L	3.25045761
5	SRPK1	2.86926365
6	TESK2	2.81684349
7	FRK	2.78620836
8	STK16	2.67015661
9	CDK19	2.57998889
10	CLK1	2.55304785
11	MAP3K12	2.52172247
12	BUB1	2.18793180
13	LIMK1	1.99146045
14	WNK3	1.87571657
15	TLK1	1.83450507
16	TESK1	1.79655958
17	PDK2	1.78254994
18	WNK4	1.77692243
19	PLK1	1.68952397
20	MAP3K11	1.68492630
21	INSRR	1.65253646
22	MST4	1.58804047
23	BRSK2	1.48891246
24	EIF2AK3	1.47263965
25	KDR	1.44308112
26	GRK1	1.43180778
27	STK39	1.27480617
28	ABL2	1.27123509
29	NTRK3	1.19097439
30	PINK1	1.17541558
31	MAP2K7	1.17251590
32	ACVR1B	1.14770997
33	AURKA	1.14207692
34	PLK3	1.12588517
35	OXSR1	1.09139061
36	VRK1	1.06328622
37	NUAK1	1.05202919
38	PLK2	1.04957749
39	WEE1	1.04402245
40	MAP3K4	1.00482064
41	ADRBK2	0.99980610
42	DYRK3	0.99441564
43	MAP3K2	0.97180814
44	ZAK	0.96730784
45	EPHA4	0.95128575
46	PIK3CG	0.89915073
47	NEK1	0.89811287
48	PRKCE	0.85886324
49	MAPK13	0.84169291
50	PNCK	0.79752617
51	STK3	0.76018553
52	VRK2	0.75342647
53	GRK7	0.75005581
54	AURKB	0.73453881
55	PKN1	0.70870618
56	PRKCG	0.70453644
57	IRAK2	0.68878151
58	BCR	0.67993932
59	NEK6	0.66917468
60	TAOK3	0.66637842
61	TNIK	0.65769609
62	BRSK1	0.62443509
63	MYLK	0.62429276
64	PAK3	0.61832255
65	BMPR1B	0.60534486
66	NME1	0.60533368
67	ATR	0.58577294
68	MARK1	0.58204222
69	BCKDK	0.57070884
70	STK24	0.56746279
71	DYRK2	0.55646212
72	TTK	0.51310225
73	MAP3K5	0.50529987
74	CSNK2A2	0.50392430
75	CSNK1G1	0.48400452
76	CSNK2A1	0.47599868
77	CHEK1	0.46653517
78	RPS6KA5	0.40396479
79	TIE1	0.39999575
80	ERBB3	0.39589595
81	MAP4K2	0.39536597
82	PRKACA	0.38970556
83	CAMK2A	0.34709654
84	ATM	0.33748214
85	CDK7	0.33474620
86	BMPR2	0.31735771
87	PBK	0.31509371
88	PRKG1	0.30156561
89	EIF2AK1	0.30055132
90	CSNK1G2	0.29364593
91	ABL1	0.29106876
92	PRKCA	0.28731055
93	OBSCN	0.28579092
94	CSNK1G3	0.26862948
95	ADRBK1	0.26322194
96	IGF1R	0.26260287
97	MARK3	0.25648053
98	PRKACB	0.24366063
99	EGFR	0.24053963
100	CDK1	0.23109259

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.85445642
2	Proteasome_Homo sapiens_hsa03050	3.86852343
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.79112726
4	Regulation of autophagy_Homo sapiens_hsa04140	2.71988916
5	RNA polymerase_Homo sapiens_hsa03020	2.69241851
6	Parkinsons disease_Homo sapiens_hsa05012	2.60933829
7	Basal transcription factors_Homo sapiens_hsa03022	2.55686638
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.48837904
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.40612946
10	Protein export_Homo sapiens_hsa03060	2.35544392
11	RNA transport_Homo sapiens_hsa03013	2.22328809
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03298190
13	Huntingtons disease_Homo sapiens_hsa05016	2.03212338
14	Ribosome_Homo sapiens_hsa03010	2.00170682
15	Fatty acid elongation_Homo sapiens_hsa00062	1.82307924
16	Butanoate metabolism_Homo sapiens_hsa00650	1.74933433
17	Propanoate metabolism_Homo sapiens_hsa00640	1.70037852
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.65850884
19	Homologous recombination_Homo sapiens_hsa03440	1.60811097
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.59290359
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.57743206
22	Mismatch repair_Homo sapiens_hsa03430	1.55791025
23	Folate biosynthesis_Homo sapiens_hsa00790	1.54469020
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.54036030
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53248467
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52725701
27	Olfactory transduction_Homo sapiens_hsa04740	1.51148538
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50681007
29	Spliceosome_Homo sapiens_hsa03040	1.45734064
30	Alzheimers disease_Homo sapiens_hsa05010	1.43388407
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43354714
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32167496
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28772895
34	DNA replication_Homo sapiens_hsa03030	1.22482761
35	Nicotine addiction_Homo sapiens_hsa05033	1.19238811
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.18988637
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16513050
38	Taste transduction_Homo sapiens_hsa04742	1.13828381
39	Asthma_Homo sapiens_hsa05310	1.13448252
40	Phototransduction_Homo sapiens_hsa04744	1.12002868
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.11584895
42	RNA degradation_Homo sapiens_hsa03018	1.08475965
43	Cell cycle_Homo sapiens_hsa04110	1.04733455
44	Oocyte meiosis_Homo sapiens_hsa04114	0.96513806
45	Antigen processing and presentation_Homo sapiens_hsa04612	0.93212181
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.92086818
47	p53 signaling pathway_Homo sapiens_hsa04115	0.89917706
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88902642
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87349915
50	Allograft rejection_Homo sapiens_hsa05330	0.86785747
51	Retinol metabolism_Homo sapiens_hsa00830	0.85832593
52	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.84441884
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83524016
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.79835741
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79338810
56	Graft-versus-host disease_Homo sapiens_hsa05332	0.77191386
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74097535
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.72955409
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.70889506
60	Purine metabolism_Homo sapiens_hsa00230	0.69671304
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64270061
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.63098255
63	GABAergic synapse_Homo sapiens_hsa04727	0.61348000
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.61215696
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59972307
66	Peroxisome_Homo sapiens_hsa04146	0.59749706
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59024896
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.56605543
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56578957
70	Serotonergic synapse_Homo sapiens_hsa04726	0.56044238
71	Metabolic pathways_Homo sapiens_hsa01100	0.55436544
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.53397017
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.51908572
74	Morphine addiction_Homo sapiens_hsa05032	0.51007360
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.50051366
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49946512
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49171690
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47726202
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44781453
80	Viral myocarditis_Homo sapiens_hsa05416	0.43976456
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42508545
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39245842
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39058928
84	Base excision repair_Homo sapiens_hsa03410	0.37654960
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.37519891
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36098977
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34567739
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.32028751
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.31028603
90	Circadian entrainment_Homo sapiens_hsa04713	0.29229772
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27575390
92	Nitrogen metabolism_Homo sapiens_hsa00910	0.25624703
93	One carbon pool by folate_Homo sapiens_hsa00670	0.24569885
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.23759119
95	Fatty acid degradation_Homo sapiens_hsa00071	0.22638845
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.20503874
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.19349942
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.19000801
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.18958504
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.18369273

ZNF479

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »