ZNF484

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.15641393
2response to pheromone (GO:0019236)4.82921276
3proline transport (GO:0015824)4.64130486
4neural tube formation (GO:0001841)4.51315319
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.28048588
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.28048588
7regulation of translation, ncRNA-mediated (GO:0045974)4.28048588
8nucleobase catabolic process (GO:0046113)4.20661863
9DNA double-strand break processing (GO:0000729)4.03515988
10positive regulation of mitochondrial fission (GO:0090141)3.71565941
11DNA integration (GO:0015074)3.65506297
12positive regulation of developmental pigmentation (GO:0048087)3.60156385
13neurotransmitter-gated ion channel clustering (GO:0072578)3.51693805
14axonal fasciculation (GO:0007413)3.44974015
15cullin deneddylation (GO:0010388)3.35950789
16protein K11-linked deubiquitination (GO:0035871)3.35691220
17retinal cone cell development (GO:0046549)3.31750313
18presynaptic membrane assembly (GO:0097105)3.31032553
19presynaptic membrane organization (GO:0097090)3.28205989
20histone H2A acetylation (GO:0043968)3.26867574
21establishment of protein localization to Golgi (GO:0072600)3.24110017
22neuron recognition (GO:0008038)3.18096439
23protein targeting to Golgi (GO:0000042)3.16042260
24mitotic sister chromatid cohesion (GO:0007064)3.10470313
25glycosphingolipid biosynthetic process (GO:0006688)3.10023490
26gamma-aminobutyric acid transport (GO:0015812)3.07187704
27microtubule anchoring (GO:0034453)3.06692942
28central nervous system neuron axonogenesis (GO:0021955)3.05401137
29prenylation (GO:0097354)3.04182037
30protein prenylation (GO:0018342)3.04182037
31regulation of telomere maintenance (GO:0032204)3.02352667
32olfactory bulb development (GO:0021772)3.01336561
33protein deneddylation (GO:0000338)2.97668064
34central nervous system projection neuron axonogenesis (GO:0021952)2.95685392
35L-fucose catabolic process (GO:0042355)2.91315549
36fucose catabolic process (GO:0019317)2.91315549
37L-fucose metabolic process (GO:0042354)2.91315549
38positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.90849964
39mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.90849964
40establishment of nucleus localization (GO:0040023)2.85915262
41heparin biosynthetic process (GO:0030210)2.85817364
42heparin metabolic process (GO:0030202)2.85817364
43retinal ganglion cell axon guidance (GO:0031290)2.83048810
44brain morphogenesis (GO:0048854)2.82800378
45nucleus localization (GO:0051647)2.81621119
46protein polyglutamylation (GO:0018095)2.80896537
47neurofilament cytoskeleton organization (GO:0060052)2.80804761
48behavioral response to ethanol (GO:0048149)2.80488721
49regulation of helicase activity (GO:0051095)2.79974660
50negative regulation of dendrite development (GO:2000171)2.77091923
51histone mRNA catabolic process (GO:0071044)2.76460775
52keratinocyte development (GO:0003334)2.73626556
53retrograde transport, vesicle recycling within Golgi (GO:0000301)2.72315005
54vocalization behavior (GO:0071625)2.70407129
55negative regulation of DNA recombination (GO:0045910)2.70353693
56anterograde synaptic vesicle transport (GO:0048490)2.70073386
57regulation of pigment cell differentiation (GO:0050932)2.62952538
58protein K48-linked ubiquitination (GO:0070936)2.60983718
59intraciliary transport (GO:0042073)2.60170760
60regulation of development, heterochronic (GO:0040034)2.59927662
61regulation of mitochondrial fission (GO:0090140)2.59700610
62glial cell proliferation (GO:0014009)2.58400576
63negative regulation of neurotransmitter transport (GO:0051589)2.57935151
64regulation of dendritic spine morphogenesis (GO:0061001)2.57639108
65synapse assembly (GO:0007416)2.56576571
66head development (GO:0060322)2.56312316
67hippocampus development (GO:0021766)2.55790347
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55555554
69limb bud formation (GO:0060174)2.52455382
70histone H3-K4 trimethylation (GO:0080182)2.51488956
71regulation of telomere maintenance via telomerase (GO:0032210)2.50659703
72inositol phosphate catabolic process (GO:0071545)2.50657673
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49217902
74cilium organization (GO:0044782)2.47645759
75intra-Golgi vesicle-mediated transport (GO:0006891)2.47553422
76regulation of timing of cell differentiation (GO:0048505)2.46846471
77regulation of axon regeneration (GO:0048679)2.46730740
78regulation of neuron projection regeneration (GO:0070570)2.46730740
79interkinetic nuclear migration (GO:0022027)2.46449440
80neuronal action potential propagation (GO:0019227)2.44070654
81glutamate receptor signaling pathway (GO:0007215)2.42991841
82cytoplasmic mRNA processing body assembly (GO:0033962)2.42265309
83retinal rod cell development (GO:0046548)2.41375567
84cilium assembly (GO:0042384)2.40772826
85kidney morphogenesis (GO:0060993)2.40355743
86somite rostral/caudal axis specification (GO:0032525)2.39820257
87protein sumoylation (GO:0016925)2.36758008
88sister chromatid cohesion (GO:0007062)2.36700935
89peptidyl-lysine trimethylation (GO:0018023)2.36354371
90protein localization to cilium (GO:0061512)2.35872217
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.35062397
92regulation of feeding behavior (GO:0060259)2.32562983
93monoubiquitinated protein deubiquitination (GO:0035520)2.32168138
94regulation of DNA endoreduplication (GO:0032875)2.31290381
95DNA damage response, detection of DNA damage (GO:0042769)2.31202391
96resolution of meiotic recombination intermediates (GO:0000712)2.30745704
97neuron cell-cell adhesion (GO:0007158)2.30608509
98positive regulation of mRNA processing (GO:0050685)2.30540781
99snRNA transcription (GO:0009301)2.30200063
100acrosome reaction (GO:0007340)2.29719216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1POU3F2_20337985_ChIP-ChIP_501MEL_Human3.36832512
2IGF1R_20145208_ChIP-Seq_DFB_Human3.31669866
3TAF15_26573619_Chip-Seq_HEK293_Human3.30120299
4GBX2_23144817_ChIP-Seq_PC3_Human3.27573561
5ZNF274_21170338_ChIP-Seq_K562_Hela3.21293854
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.10841795
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.99806778
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95817737
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.84931327
10FUS_26573619_Chip-Seq_HEK293_Human2.56551216
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56199036
12EWS_26573619_Chip-Seq_HEK293_Human2.43695467
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24601866
14P300_19829295_ChIP-Seq_ESCs_Human2.19474202
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.14436942
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08302846
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98370676
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97017536
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96271597
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96244914
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95000213
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94790993
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93348288
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.90123869
25VDR_22108803_ChIP-Seq_LS180_Human1.89318874
26SMAD4_21799915_ChIP-Seq_A2780_Human1.83445973
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82630353
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81524211
29ELK1_19687146_ChIP-ChIP_HELA_Human1.72550001
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.72518468
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69081351
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.68328179
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64931630
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64170202
35STAT3_23295773_ChIP-Seq_U87_Human1.58770608
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56584724
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53325514
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.51278792
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50387502
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49858036
41ER_23166858_ChIP-Seq_MCF-7_Human1.48439674
42CBP_20019798_ChIP-Seq_JUKART_Human1.47767324
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47767324
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.43782139
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42549979
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40944600
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40755564
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40652830
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.40586315
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39769981
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39348494
52IRF1_19129219_ChIP-ChIP_H3396_Human1.39226264
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.37496491
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.37407523
55TCF4_23295773_ChIP-Seq_U87_Human1.37305014
56AR_25329375_ChIP-Seq_VCAP_Human1.35529641
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.32657323
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32428278
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31503950
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30451820
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29750591
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29280477
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28329235
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26014582
65* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24928348
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24898804
67P53_22387025_ChIP-Seq_ESCs_Mouse1.24638682
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24429104
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.24113176
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24068443
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22725014
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22725014
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.21825033
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20455118
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.20294691
76* VDR_23849224_ChIP-Seq_CD4+_Human1.18931730
77RUNX2_22187159_ChIP-Seq_PCA_Human1.18526250
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.16873619
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15612057
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.15058665
81AR_21572438_ChIP-Seq_LNCaP_Human1.14248677
82BCAT_22108803_ChIP-Seq_LS180_Human1.14080515
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12781032
84TP53_22573176_ChIP-Seq_HFKS_Human1.12209071
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12194361
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10972345
87SOX9_26525672_Chip-Seq_HEART_Mouse1.10659601
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08742845
89KDM2B_26808549_Chip-Seq_REH_Human1.06963982
90P300_18555785_Chip-Seq_ESCs_Mouse1.04953690
91RNF2_27304074_Chip-Seq_NSC_Mouse1.04638442
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.04588687
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01680381
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.01474764
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00930632
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00347234
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.99524586
98TCF4_22108803_ChIP-Seq_LS180_Human0.99282731
99JUN_21703547_ChIP-Seq_K562_Human0.98124366
100SOX2_18555785_Chip-Seq_ESCs_Mouse0.97727687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.43002851
2MP0000569_abnormal_digit_pigmentation4.35264840
3MP0003880_abnormal_central_pattern3.86926896
4MP0008877_abnormal_DNA_methylation3.05090976
5MP0003787_abnormal_imprinting2.88379042
6MP0005645_abnormal_hypothalamus_physiol2.23199574
7MP0000778_abnormal_nervous_system2.17332432
8MP0004270_analgesia2.14417998
9MP0003890_abnormal_embryonic-extraembry2.14350962
10MP0003221_abnormal_cardiomyocyte_apopto2.12770670
11MP0003121_genomic_imprinting2.06566552
12MP0002822_catalepsy2.03979983
13MP0001984_abnormal_olfaction2.03310682
14MP0001188_hyperpigmentation1.94051116
15MP0009046_muscle_twitch1.88682885
16MP0001529_abnormal_vocalization1.86859337
17MP0002751_abnormal_autonomic_nervous1.83481243
18MP0002837_dystrophic_cardiac_calcinosis1.80411669
19MP0005394_taste/olfaction_phenotype1.78309896
20MP0005499_abnormal_olfactory_system1.78309896
21MP0008058_abnormal_DNA_repair1.69968849
22MP0008789_abnormal_olfactory_epithelium1.66768627
23MP0005253_abnormal_eye_physiology1.62132733
24MP0003122_maternal_imprinting1.59300709
25MP0009745_abnormal_behavioral_response1.54723554
26MP0006072_abnormal_retinal_apoptosis1.53721469
27MP0001968_abnormal_touch/_nociception1.49620639
28MP0009697_abnormal_copulation1.44641226
29MP0000427_abnormal_hair_cycle1.41944177
30MP0005551_abnormal_eye_electrophysiolog1.41094148
31MP0003635_abnormal_synaptic_transmissio1.40840851
32MP0002272_abnormal_nervous_system1.39794012
33MP0001986_abnormal_taste_sensitivity1.37326992
34MP0002184_abnormal_innervation1.37168661
35MP0008057_abnormal_DNA_replication1.36900831
36MP0005248_abnormal_Harderian_gland1.32394232
37MP0001486_abnormal_startle_reflex1.32025557
38MP0006276_abnormal_autonomic_nervous1.25482698
39MP0010352_gastrointestinal_tract_polyps1.24805107
40MP0002063_abnormal_learning/memory/cond1.23581041
41MP0002734_abnormal_mechanical_nocicepti1.23551008
42MP0004811_abnormal_neuron_physiology1.22076701
43MP0006292_abnormal_olfactory_placode1.18134445
44MP0004924_abnormal_behavior1.17208546
45MP0005386_behavior/neurological_phenoty1.17208546
46MP0000647_abnormal_sebaceous_gland1.15397765
47MP0004142_abnormal_muscle_tone1.14547333
48MP0005187_abnormal_penis_morphology1.13511594
49MP0006035_abnormal_mitochondrial_morpho1.12939252
50MP0004859_abnormal_synaptic_plasticity1.12398399
51MP0005310_abnormal_salivary_gland1.11036888
52MP0001177_atelectasis1.10388990
53MP0002736_abnormal_nociception_after1.08779185
54MP0003937_abnormal_limbs/digits/tail_de1.08505561
55MP0002882_abnormal_neuron_morphology1.07151258
56MP0004215_abnormal_myocardial_fiber1.06380388
57MP0002233_abnormal_nose_morphology1.05217909
58MP0002067_abnormal_sensory_capabilities1.04930140
59MP0003119_abnormal_digestive_system1.04649471
60MP0000955_abnormal_spinal_cord1.04595442
61MP0002163_abnormal_gland_morphology1.02764131
62MP0005423_abnormal_somatic_nervous1.02677161
63MP0003718_maternal_effect1.01812867
64MP0002064_seizures1.01739927
65MP0002090_abnormal_vision1.00742631
66MP0003693_abnormal_embryo_hatching1.00104343
67MP0001286_abnormal_eye_development1.00084009
68MP0002572_abnormal_emotion/affect_behav0.99051441
69MP0000631_abnormal_neuroendocrine_gland0.98135610
70MP0004145_abnormal_muscle_electrophysio0.94893496
71MP0005174_abnormal_tail_pigmentation0.93958566
72MP0004197_abnormal_fetal_growth/weight/0.93928631
73MP0002735_abnormal_chemical_nociception0.92698534
74MP0003861_abnormal_nervous_system0.92123388
75MP0005379_endocrine/exocrine_gland_phen0.91976130
76MP0009703_decreased_birth_body0.90913026
77MP0001485_abnormal_pinna_reflex0.89670333
78MP0002557_abnormal_social/conspecific_i0.89665507
79MP0001502_abnormal_circadian_rhythm0.89136084
80MP0000015_abnormal_ear_pigmentation0.87765150
81MP0002752_abnormal_somatic_nervous0.87690650
82MP0002152_abnormal_brain_morphology0.85939785
83MP0001293_anophthalmia0.84362497
84MP0004134_abnormal_chest_morphology0.83914103
85MP0003941_abnormal_skin_development0.83398655
86MP0005391_vision/eye_phenotype0.82956172
87MP0005195_abnormal_posterior_eye0.80566511
88MP0001299_abnormal_eye_distance/0.79335742
89MP0004133_heterotaxia0.79296429
90MP0005367_renal/urinary_system_phenotyp0.76692775
91MP0000516_abnormal_urinary_system0.76692775
92MP0003633_abnormal_nervous_system0.75714514
93MP0003755_abnormal_palate_morphology0.75658990
94MP0002069_abnormal_eating/drinking_beha0.74083763
95MP0001929_abnormal_gametogenesis0.73231867
96MP0002095_abnormal_skin_pigmentation0.73091755
97MP0008995_early_reproductive_senescence0.72006574
98MP0002234_abnormal_pharynx_morphology0.70834965
99MP0002066_abnormal_motor_capabilities/c0.70610668
100MP0001764_abnormal_homeostasis0.70558777

Predicted human phenotypes

RankGene SetZ-score
1Drooling (HP:0002307)3.75717639
2Progressive inability to walk (HP:0002505)3.65007809
3Excessive salivation (HP:0003781)3.48090622
4Hyperventilation (HP:0002883)3.46191086
5Abnormality of the labia minora (HP:0012880)3.24411901
6Colon cancer (HP:0003003)3.23607675
7Medial flaring of the eyebrow (HP:0010747)3.20229006
8Absent speech (HP:0001344)3.18325732
9Neoplasm of the adrenal cortex (HP:0100641)3.10853808
10Gait imbalance (HP:0002141)3.03605537
11Hepatoblastoma (HP:0002884)3.02566657
12Congenital primary aphakia (HP:0007707)3.01147238
13Volvulus (HP:0002580)2.92142243
14Nephrogenic diabetes insipidus (HP:0009806)2.91866650
15Genital tract atresia (HP:0001827)2.81652367
16Abnormal hair whorl (HP:0010721)2.78843946
17Intestinal atresia (HP:0011100)2.77630261
18Vaginal atresia (HP:0000148)2.69971603
19Inability to walk (HP:0002540)2.65387540
20Papillary thyroid carcinoma (HP:0002895)2.62703649
21Widely spaced teeth (HP:0000687)2.57951959
22Pancreatic fibrosis (HP:0100732)2.52642300
23Chronic hepatic failure (HP:0100626)2.51107261
24Tubulointerstitial nephritis (HP:0001970)2.49372552
25Hip dysplasia (HP:0001385)2.48151947
26Lissencephaly (HP:0001339)2.48023168
27Abnormality of the astrocytes (HP:0100707)2.45066635
28Astrocytoma (HP:0009592)2.45066635
29Febrile seizures (HP:0002373)2.44580772
30Aqueductal stenosis (HP:0002410)2.43709687
31Broad-based gait (HP:0002136)2.34613572
32Abnormality of the hip-girdle musculature (HP:0001445)2.33747607
33Abnormality of the musculature of the pelvis (HP:0001469)2.33747607
34Submucous cleft hard palate (HP:0000176)2.32272190
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31483340
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.31483340
37Poor coordination (HP:0002370)2.31112503
38Glioma (HP:0009733)2.30671461
39Neoplasm of the adrenal gland (HP:0100631)2.24857419
40Fair hair (HP:0002286)2.24829185
41Hypsarrhythmia (HP:0002521)2.24171088
42Type II lissencephaly (HP:0007260)2.23374793
43Renal cortical cysts (HP:0000803)2.21581559
44Cortical dysplasia (HP:0002539)2.20238638
45Protruding tongue (HP:0010808)2.18657859
46Optic nerve hypoplasia (HP:0000609)2.17336332
47Retinal dysplasia (HP:0007973)2.16666100
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.15270122
49Molar tooth sign on MRI (HP:0002419)2.14288638
50Abnormality of midbrain morphology (HP:0002418)2.14288638
51Abnormality of the corticospinal tract (HP:0002492)2.14252053
52Nephronophthisis (HP:0000090)2.14146415
53Methylmalonic acidemia (HP:0002912)2.13450452
54EEG with generalized epileptiform discharges (HP:0011198)2.12906931
55Hypothermia (HP:0002045)2.11347728
56Abnormality of the metopic suture (HP:0005556)2.10971658
57Ulnar claw (HP:0001178)2.10777193
58Cupped ear (HP:0000378)2.08329354
59Thyroid carcinoma (HP:0002890)2.06302672
60Epileptiform EEG discharges (HP:0011182)2.05637747
61Short tibia (HP:0005736)2.04019660
62Abnormality of the renal cortex (HP:0011035)2.03451809
63Pancreatic cysts (HP:0001737)2.00540084
64Thyroiditis (HP:0100646)2.00501363
65True hermaphroditism (HP:0010459)2.00288624
66Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98737086
67Postaxial foot polydactyly (HP:0001830)1.97333602
68Impaired vibration sensation in the lower limbs (HP:0002166)1.96656547
69Urinary urgency (HP:0000012)1.95918009
70Medulloblastoma (HP:0002885)1.94595234
71Abnormality of salivation (HP:0100755)1.91808046
72Abnormality of the renal medulla (HP:0100957)1.89173509
73Septo-optic dysplasia (HP:0100842)1.89155684
74Specific learning disability (HP:0001328)1.86322988
75Narrow forehead (HP:0000341)1.85307660
76Polyphagia (HP:0002591)1.85257984
77Prominent metopic ridge (HP:0005487)1.85105320
78Postaxial hand polydactyly (HP:0001162)1.84527504
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84388199
80Focal motor seizures (HP:0011153)1.84002822
81Neoplasm of the oral cavity (HP:0100649)1.83997378
82Labial hypoplasia (HP:0000066)1.81925325
83Abolished electroretinogram (ERG) (HP:0000550)1.81779139
84Oligodactyly (hands) (HP:0001180)1.80516179
85Progressive cerebellar ataxia (HP:0002073)1.79508338
86Ependymoma (HP:0002888)1.75668518
87Broad foot (HP:0001769)1.74741524
88Pelvic girdle muscle weakness (HP:0003749)1.73685041
89Bifid tongue (HP:0010297)1.72445769
90Decreased lacrimation (HP:0000633)1.69082489
91Short foot (HP:0001773)1.69040691
92Shoulder girdle muscle weakness (HP:0003547)1.68902222
93Inappropriate behavior (HP:0000719)1.68365736
94Micropenis (HP:0000054)1.65342900
95Small hand (HP:0200055)1.63989476
96Abnormality of vitamin B metabolism (HP:0004340)1.63960082
97Generalized hypopigmentation of hair (HP:0011358)1.63938752
98Hypoplastic pelvis (HP:0008839)1.62456182
99Hemiparesis (HP:0001269)1.61798511
100Hypoplastic female external genitalia (HP:0012815)1.61687801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.91478535
2TRIM283.88429733
3BCR3.78107135
4FRK3.54415579
5MAP3K43.20116393
6WNK32.93504670
7CASK2.62207453
8EPHA42.56665939
9MARK12.40216314
10ERBB32.34800078
11MAP2K72.25414577
12BRD42.23794772
13CSNK1G22.14618841
14MAPK132.14359768
15CSNK1G32.02998469
16CSNK1A1L2.01686260
17AKT31.95039776
18CSNK1G11.93768486
19EIF2AK31.86498261
20MKNK21.80048917
21BMPR1B1.58744546
22NTRK31.50932777
23EPHA31.50051516
24ZAK1.43742977
25RPS6KA41.31164011
26NUAK11.30417465
27ADRBK21.23126275
28STK38L1.19311355
29DYRK31.19260287
30DYRK21.16611973
31TSSK61.14528513
32MKNK11.13304873
33PLK31.11008425
34SRPK11.10296103
35PLK21.08582090
36SGK21.07899780
37TNIK1.07621424
38PAK31.02918126
39MINK10.99461053
40VRK10.97387239
41PRKCE0.93361023
42BRSK20.90083166
43FGFR20.85046495
44ACVR1B0.84151871
45MAP2K40.84001218
46EIF2AK10.77893803
47OXSR10.76056550
48PNCK0.74734622
49NLK0.74295536
50SIK30.73354181
51SGK2230.70814188
52SGK4940.70814188
53BCKDK0.68905056
54INSRR0.68240904
55ATM0.63338083
56GRK10.62961096
57NEK60.61988126
58YES10.60880669
59CSNK1D0.59965939
60OBSCN0.59722863
61DYRK1A0.59141218
62CDK50.56912041
63PLK10.56525739
64NTRK20.56184341
65FER0.56055018
66UHMK10.54539910
67PRKCG0.53321650
68IRAK10.51686438
69TTK0.50195560
70STK390.48667946
71IRAK20.47879407
72MAP3K50.47607880
73PIK3CA0.45205306
74CSNK1E0.43813611
75RPS6KA50.42222507
76CSNK1A10.41680766
77CAMK2A0.41331133
78CDK190.37900412
79CAMK40.37072531
80EGFR0.36773942
81MST40.36145020
82PLK40.35724742
83PRKCZ0.34637380
84ERBB40.31789284
85ATR0.31587986
86PRKACB0.31286501
87CDK60.31283286
88EIF2AK20.31232303
89NEK10.29310798
90CHUK0.29123851
91CAMKK20.28798198
92CDK30.28363100
93STK110.27120771
94STK240.27008443
95CAMK1G0.26053134
96GRK70.25831801
97PRKG10.25099400
98SGK30.25066818
99FGFR10.24687023
100CAMK2B0.24268251

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.37976466
2Protein export_Homo sapiens_hsa030602.66828261
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63646259
4Steroid biosynthesis_Homo sapiens_hsa001002.51748788
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48377497
6Circadian rhythm_Homo sapiens_hsa047102.34676848
7Basal transcription factors_Homo sapiens_hsa030222.26069477
8Phototransduction_Homo sapiens_hsa047442.25815275
9Butanoate metabolism_Homo sapiens_hsa006502.12509212
10Taste transduction_Homo sapiens_hsa047422.08548412
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.01774236
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96692164
13RNA degradation_Homo sapiens_hsa030181.94742764
14GABAergic synapse_Homo sapiens_hsa047271.93132735
15Selenocompound metabolism_Homo sapiens_hsa004501.92450354
16Non-homologous end-joining_Homo sapiens_hsa034501.90356588
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81615567
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80188164
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77667705
20Propanoate metabolism_Homo sapiens_hsa006401.71983400
21Fanconi anemia pathway_Homo sapiens_hsa034601.64621981
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.63635564
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57920689
24Glutamatergic synapse_Homo sapiens_hsa047241.55666377
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53425101
26Regulation of autophagy_Homo sapiens_hsa041401.52180364
27Circadian entrainment_Homo sapiens_hsa047131.40434434
28Dopaminergic synapse_Homo sapiens_hsa047281.37007765
29RNA transport_Homo sapiens_hsa030131.37002876
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36899678
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35694370
32Morphine addiction_Homo sapiens_hsa050321.33771884
33Long-term depression_Homo sapiens_hsa047301.27455737
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24149066
35mRNA surveillance pathway_Homo sapiens_hsa030151.21779809
36RNA polymerase_Homo sapiens_hsa030201.19791090
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19637620
38Amphetamine addiction_Homo sapiens_hsa050311.18118282
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13791738
40Oocyte meiosis_Homo sapiens_hsa041141.05527769
41Alcoholism_Homo sapiens_hsa050341.00207095
42Cocaine addiction_Homo sapiens_hsa050300.99203461
43Vitamin B6 metabolism_Homo sapiens_hsa007500.93513602
44Peroxisome_Homo sapiens_hsa041460.92615603
45Insulin secretion_Homo sapiens_hsa049110.90569663
46Axon guidance_Homo sapiens_hsa043600.90238650
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85821311
48Cell cycle_Homo sapiens_hsa041100.84999152
49TGF-beta signaling pathway_Homo sapiens_hsa043500.84458136
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81419366
51Type II diabetes mellitus_Homo sapiens_hsa049300.80824134
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78497460
53Ether lipid metabolism_Homo sapiens_hsa005650.76614129
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76258540
55Serotonergic synapse_Homo sapiens_hsa047260.74311769
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73921951
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.73821640
58p53 signaling pathway_Homo sapiens_hsa041150.72779910
59Fatty acid elongation_Homo sapiens_hsa000620.71135816
60Renin secretion_Homo sapiens_hsa049240.68972774
61Mismatch repair_Homo sapiens_hsa034300.68840215
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68177818
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.67316822
64Colorectal cancer_Homo sapiens_hsa052100.67028130
65Collecting duct acid secretion_Homo sapiens_hsa049660.63840027
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63288735
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62732936
68Spliceosome_Homo sapiens_hsa030400.62720635
69Fatty acid metabolism_Homo sapiens_hsa012120.60803478
70Wnt signaling pathway_Homo sapiens_hsa043100.60528530
71Olfactory transduction_Homo sapiens_hsa047400.58704209
72Folate biosynthesis_Homo sapiens_hsa007900.58523831
73Synaptic vesicle cycle_Homo sapiens_hsa047210.58145311
74FoxO signaling pathway_Homo sapiens_hsa040680.58135501
75Nucleotide excision repair_Homo sapiens_hsa034200.57978066
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54725617
77Hippo signaling pathway_Homo sapiens_hsa043900.54296512
78Sphingolipid metabolism_Homo sapiens_hsa006000.53233803
79Inositol phosphate metabolism_Homo sapiens_hsa005620.53168608
80Cholinergic synapse_Homo sapiens_hsa047250.51073993
81Hedgehog signaling pathway_Homo sapiens_hsa043400.47790255
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47746490
83Homologous recombination_Homo sapiens_hsa034400.46038888
84mTOR signaling pathway_Homo sapiens_hsa041500.43462670
85cAMP signaling pathway_Homo sapiens_hsa040240.42998266
86Lysine degradation_Homo sapiens_hsa003100.40547177
87Adherens junction_Homo sapiens_hsa045200.39324258
88Tight junction_Homo sapiens_hsa045300.36659992
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.35050577
90Systemic lupus erythematosus_Homo sapiens_hsa053220.34957481
91Purine metabolism_Homo sapiens_hsa002300.34570588
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31946418
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31815606
94Nitrogen metabolism_Homo sapiens_hsa009100.30406082
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28740726
96Melanoma_Homo sapiens_hsa052180.28033688
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.26901815
98MicroRNAs in cancer_Homo sapiens_hsa052060.26773275
99Huntingtons disease_Homo sapiens_hsa050160.25526187
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25431672

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