ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.15641393
2	response to pheromone (GO:0019236)	4.82921276
3	proline transport (GO:0015824)	4.64130486
4	neural tube formation (GO:0001841)	4.51315319
5	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.28048588
6	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.28048588
7	regulation of translation, ncRNA-mediated (GO:0045974)	4.28048588
8	nucleobase catabolic process (GO:0046113)	4.20661863
9	DNA double-strand break processing (GO:0000729)	4.03515988
10	positive regulation of mitochondrial fission (GO:0090141)	3.71565941
11	DNA integration (GO:0015074)	3.65506297
12	positive regulation of developmental pigmentation (GO:0048087)	3.60156385
13	neurotransmitter-gated ion channel clustering (GO:0072578)	3.51693805
14	axonal fasciculation (GO:0007413)	3.44974015
15	cullin deneddylation (GO:0010388)	3.35950789
16	protein K11-linked deubiquitination (GO:0035871)	3.35691220
17	retinal cone cell development (GO:0046549)	3.31750313
18	presynaptic membrane assembly (GO:0097105)	3.31032553
19	presynaptic membrane organization (GO:0097090)	3.28205989
20	histone H2A acetylation (GO:0043968)	3.26867574
21	establishment of protein localization to Golgi (GO:0072600)	3.24110017
22	neuron recognition (GO:0008038)	3.18096439
23	protein targeting to Golgi (GO:0000042)	3.16042260
24	mitotic sister chromatid cohesion (GO:0007064)	3.10470313
25	glycosphingolipid biosynthetic process (GO:0006688)	3.10023490
26	gamma-aminobutyric acid transport (GO:0015812)	3.07187704
27	microtubule anchoring (GO:0034453)	3.06692942
28	central nervous system neuron axonogenesis (GO:0021955)	3.05401137
29	prenylation (GO:0097354)	3.04182037
30	protein prenylation (GO:0018342)	3.04182037
31	regulation of telomere maintenance (GO:0032204)	3.02352667
32	olfactory bulb development (GO:0021772)	3.01336561
33	protein deneddylation (GO:0000338)	2.97668064
34	central nervous system projection neuron axonogenesis (GO:0021952)	2.95685392
35	L-fucose catabolic process (GO:0042355)	2.91315549
36	fucose catabolic process (GO:0019317)	2.91315549
37	L-fucose metabolic process (GO:0042354)	2.91315549
38	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.90849964
39	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.90849964
40	establishment of nucleus localization (GO:0040023)	2.85915262
41	heparin biosynthetic process (GO:0030210)	2.85817364
42	heparin metabolic process (GO:0030202)	2.85817364
43	retinal ganglion cell axon guidance (GO:0031290)	2.83048810
44	brain morphogenesis (GO:0048854)	2.82800378
45	nucleus localization (GO:0051647)	2.81621119
46	protein polyglutamylation (GO:0018095)	2.80896537
47	neurofilament cytoskeleton organization (GO:0060052)	2.80804761
48	behavioral response to ethanol (GO:0048149)	2.80488721
49	regulation of helicase activity (GO:0051095)	2.79974660
50	negative regulation of dendrite development (GO:2000171)	2.77091923
51	histone mRNA catabolic process (GO:0071044)	2.76460775
52	keratinocyte development (GO:0003334)	2.73626556
53	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.72315005
54	vocalization behavior (GO:0071625)	2.70407129
55	negative regulation of DNA recombination (GO:0045910)	2.70353693
56	anterograde synaptic vesicle transport (GO:0048490)	2.70073386
57	regulation of pigment cell differentiation (GO:0050932)	2.62952538
58	protein K48-linked ubiquitination (GO:0070936)	2.60983718
59	intraciliary transport (GO:0042073)	2.60170760
60	regulation of development, heterochronic (GO:0040034)	2.59927662
61	regulation of mitochondrial fission (GO:0090140)	2.59700610
62	glial cell proliferation (GO:0014009)	2.58400576
63	negative regulation of neurotransmitter transport (GO:0051589)	2.57935151
64	regulation of dendritic spine morphogenesis (GO:0061001)	2.57639108
65	synapse assembly (GO:0007416)	2.56576571
66	head development (GO:0060322)	2.56312316
67	hippocampus development (GO:0021766)	2.55790347
68	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.55555554
69	limb bud formation (GO:0060174)	2.52455382
70	histone H3-K4 trimethylation (GO:0080182)	2.51488956
71	regulation of telomere maintenance via telomerase (GO:0032210)	2.50659703
72	inositol phosphate catabolic process (GO:0071545)	2.50657673
73	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49217902
74	cilium organization (GO:0044782)	2.47645759
75	intra-Golgi vesicle-mediated transport (GO:0006891)	2.47553422
76	regulation of timing of cell differentiation (GO:0048505)	2.46846471
77	regulation of axon regeneration (GO:0048679)	2.46730740
78	regulation of neuron projection regeneration (GO:0070570)	2.46730740
79	interkinetic nuclear migration (GO:0022027)	2.46449440
80	neuronal action potential propagation (GO:0019227)	2.44070654
81	glutamate receptor signaling pathway (GO:0007215)	2.42991841
82	cytoplasmic mRNA processing body assembly (GO:0033962)	2.42265309
83	retinal rod cell development (GO:0046548)	2.41375567
84	cilium assembly (GO:0042384)	2.40772826
85	kidney morphogenesis (GO:0060993)	2.40355743
86	somite rostral/caudal axis specification (GO:0032525)	2.39820257
87	protein sumoylation (GO:0016925)	2.36758008
88	sister chromatid cohesion (GO:0007062)	2.36700935
89	peptidyl-lysine trimethylation (GO:0018023)	2.36354371
90	protein localization to cilium (GO:0061512)	2.35872217
91	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.35062397
92	regulation of feeding behavior (GO:0060259)	2.32562983
93	monoubiquitinated protein deubiquitination (GO:0035520)	2.32168138
94	regulation of DNA endoreduplication (GO:0032875)	2.31290381
95	DNA damage response, detection of DNA damage (GO:0042769)	2.31202391
96	resolution of meiotic recombination intermediates (GO:0000712)	2.30745704
97	neuron cell-cell adhesion (GO:0007158)	2.30608509
98	positive regulation of mRNA processing (GO:0050685)	2.30540781
99	snRNA transcription (GO:0009301)	2.30200063
100	acrosome reaction (GO:0007340)	2.29719216

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.36832512
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.31669866
3	TAF15_26573619_Chip-Seq_HEK293_Human	3.30120299
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.27573561
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.21293854
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.10841795
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.99806778
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.95817737
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.84931327
10	FUS_26573619_Chip-Seq_HEK293_Human	2.56551216
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.56199036
12	EWS_26573619_Chip-Seq_HEK293_Human	2.43695467
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.24601866
14	P300_19829295_ChIP-Seq_ESCs_Human	2.19474202
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14436942
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.08302846
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.98370676
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.97017536
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.96271597
20	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.96244914
21	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.95000213
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94790993
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.93348288
24	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.90123869
25	VDR_22108803_ChIP-Seq_LS180_Human	1.89318874
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83445973
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.82630353
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.81524211
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.72550001
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72518468
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69081351
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68328179
33	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64931630
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64170202
35	STAT3_23295773_ChIP-Seq_U87_Human	1.58770608
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56584724
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.53325514
38	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.51278792
39	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.50387502
40	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.49858036
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.48439674
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.47767324
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47767324
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43782139
45	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.42549979
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40944600
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40755564
48	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.40652830
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40586315
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39769981
51	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.39348494
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39226264
53	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.37496491
54	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.37407523
55	TCF4_23295773_ChIP-Seq_U87_Human	1.37305014
56	AR_25329375_ChIP-Seq_VCAP_Human	1.35529641
57	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.32657323
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32428278
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31503950
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30451820
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29750591
62	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29280477
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28329235
64	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.26014582
65	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24928348
66	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.24898804
67	P53_22387025_ChIP-Seq_ESCs_Mouse	1.24638682
68	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.24429104
69	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.24113176
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24068443
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22725014
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22725014
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21825033
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20455118
75	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.20294691
76	* VDR_23849224_ChIP-Seq_CD4+_Human	1.18931730
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18526250
78	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16873619
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15612057
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15058665
81	AR_21572438_ChIP-Seq_LNCaP_Human	1.14248677
82	BCAT_22108803_ChIP-Seq_LS180_Human	1.14080515
83	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12781032
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.12209071
85	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12194361
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10972345
87	SOX9_26525672_Chip-Seq_HEART_Mouse	1.10659601
88	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.08742845
89	KDM2B_26808549_Chip-Seq_REH_Human	1.06963982
90	P300_18555785_Chip-Seq_ESCs_Mouse	1.04953690
91	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04638442
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04588687
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01680381
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01474764
95	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.00930632
96	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00347234
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99524586
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.99282731
99	JUN_21703547_ChIP-Seq_K562_Human	0.98124366
100	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.97727687

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.43002851
2	MP0000569_abnormal_digit_pigmentation	4.35264840
3	MP0003880_abnormal_central_pattern	3.86926896
4	MP0008877_abnormal_DNA_methylation	3.05090976
5	MP0003787_abnormal_imprinting	2.88379042
6	MP0005645_abnormal_hypothalamus_physiol	2.23199574
7	MP0000778_abnormal_nervous_system	2.17332432
8	MP0004270_analgesia	2.14417998
9	MP0003890_abnormal_embryonic-extraembry	2.14350962
10	MP0003221_abnormal_cardiomyocyte_apopto	2.12770670
11	MP0003121_genomic_imprinting	2.06566552
12	MP0002822_catalepsy	2.03979983
13	MP0001984_abnormal_olfaction	2.03310682
14	MP0001188_hyperpigmentation	1.94051116
15	MP0009046_muscle_twitch	1.88682885
16	MP0001529_abnormal_vocalization	1.86859337
17	MP0002751_abnormal_autonomic_nervous	1.83481243
18	MP0002837_dystrophic_cardiac_calcinosis	1.80411669
19	MP0005394_taste/olfaction_phenotype	1.78309896
20	MP0005499_abnormal_olfactory_system	1.78309896
21	MP0008058_abnormal_DNA_repair	1.69968849
22	MP0008789_abnormal_olfactory_epithelium	1.66768627
23	MP0005253_abnormal_eye_physiology	1.62132733
24	MP0003122_maternal_imprinting	1.59300709
25	MP0009745_abnormal_behavioral_response	1.54723554
26	MP0006072_abnormal_retinal_apoptosis	1.53721469
27	MP0001968_abnormal_touch/_nociception	1.49620639
28	MP0009697_abnormal_copulation	1.44641226
29	MP0000427_abnormal_hair_cycle	1.41944177
30	MP0005551_abnormal_eye_electrophysiolog	1.41094148
31	MP0003635_abnormal_synaptic_transmissio	1.40840851
32	MP0002272_abnormal_nervous_system	1.39794012
33	MP0001986_abnormal_taste_sensitivity	1.37326992
34	MP0002184_abnormal_innervation	1.37168661
35	MP0008057_abnormal_DNA_replication	1.36900831
36	MP0005248_abnormal_Harderian_gland	1.32394232
37	MP0001486_abnormal_startle_reflex	1.32025557
38	MP0006276_abnormal_autonomic_nervous	1.25482698
39	MP0010352_gastrointestinal_tract_polyps	1.24805107
40	MP0002063_abnormal_learning/memory/cond	1.23581041
41	MP0002734_abnormal_mechanical_nocicepti	1.23551008
42	MP0004811_abnormal_neuron_physiology	1.22076701
43	MP0006292_abnormal_olfactory_placode	1.18134445
44	MP0004924_abnormal_behavior	1.17208546
45	MP0005386_behavior/neurological_phenoty	1.17208546
46	MP0000647_abnormal_sebaceous_gland	1.15397765
47	MP0004142_abnormal_muscle_tone	1.14547333
48	MP0005187_abnormal_penis_morphology	1.13511594
49	MP0006035_abnormal_mitochondrial_morpho	1.12939252
50	MP0004859_abnormal_synaptic_plasticity	1.12398399
51	MP0005310_abnormal_salivary_gland	1.11036888
52	MP0001177_atelectasis	1.10388990
53	MP0002736_abnormal_nociception_after	1.08779185
54	MP0003937_abnormal_limbs/digits/tail_de	1.08505561
55	MP0002882_abnormal_neuron_morphology	1.07151258
56	MP0004215_abnormal_myocardial_fiber	1.06380388
57	MP0002233_abnormal_nose_morphology	1.05217909
58	MP0002067_abnormal_sensory_capabilities	1.04930140
59	MP0003119_abnormal_digestive_system	1.04649471
60	MP0000955_abnormal_spinal_cord	1.04595442
61	MP0002163_abnormal_gland_morphology	1.02764131
62	MP0005423_abnormal_somatic_nervous	1.02677161
63	MP0003718_maternal_effect	1.01812867
64	MP0002064_seizures	1.01739927
65	MP0002090_abnormal_vision	1.00742631
66	MP0003693_abnormal_embryo_hatching	1.00104343
67	MP0001286_abnormal_eye_development	1.00084009
68	MP0002572_abnormal_emotion/affect_behav	0.99051441
69	MP0000631_abnormal_neuroendocrine_gland	0.98135610
70	MP0004145_abnormal_muscle_electrophysio	0.94893496
71	MP0005174_abnormal_tail_pigmentation	0.93958566
72	MP0004197_abnormal_fetal_growth/weight/	0.93928631
73	MP0002735_abnormal_chemical_nociception	0.92698534
74	MP0003861_abnormal_nervous_system	0.92123388
75	MP0005379_endocrine/exocrine_gland_phen	0.91976130
76	MP0009703_decreased_birth_body	0.90913026
77	MP0001485_abnormal_pinna_reflex	0.89670333
78	MP0002557_abnormal_social/conspecific_i	0.89665507
79	MP0001502_abnormal_circadian_rhythm	0.89136084
80	MP0000015_abnormal_ear_pigmentation	0.87765150
81	MP0002752_abnormal_somatic_nervous	0.87690650
82	MP0002152_abnormal_brain_morphology	0.85939785
83	MP0001293_anophthalmia	0.84362497
84	MP0004134_abnormal_chest_morphology	0.83914103
85	MP0003941_abnormal_skin_development	0.83398655
86	MP0005391_vision/eye_phenotype	0.82956172
87	MP0005195_abnormal_posterior_eye	0.80566511
88	MP0001299_abnormal_eye_distance/	0.79335742
89	MP0004133_heterotaxia	0.79296429
90	MP0005367_renal/urinary_system_phenotyp	0.76692775
91	MP0000516_abnormal_urinary_system	0.76692775
92	MP0003633_abnormal_nervous_system	0.75714514
93	MP0003755_abnormal_palate_morphology	0.75658990
94	MP0002069_abnormal_eating/drinking_beha	0.74083763
95	MP0001929_abnormal_gametogenesis	0.73231867
96	MP0002095_abnormal_skin_pigmentation	0.73091755
97	MP0008995_early_reproductive_senescence	0.72006574
98	MP0002234_abnormal_pharynx_morphology	0.70834965
99	MP0002066_abnormal_motor_capabilities/c	0.70610668
100	MP0001764_abnormal_homeostasis	0.70558777

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Drooling (HP:0002307)	3.75717639
2	Progressive inability to walk (HP:0002505)	3.65007809
3	Excessive salivation (HP:0003781)	3.48090622
4	Hyperventilation (HP:0002883)	3.46191086
5	Abnormality of the labia minora (HP:0012880)	3.24411901
6	Colon cancer (HP:0003003)	3.23607675
7	Medial flaring of the eyebrow (HP:0010747)	3.20229006
8	Absent speech (HP:0001344)	3.18325732
9	Neoplasm of the adrenal cortex (HP:0100641)	3.10853808
10	Gait imbalance (HP:0002141)	3.03605537
11	Hepatoblastoma (HP:0002884)	3.02566657
12	Congenital primary aphakia (HP:0007707)	3.01147238
13	Volvulus (HP:0002580)	2.92142243
14	Nephrogenic diabetes insipidus (HP:0009806)	2.91866650
15	Genital tract atresia (HP:0001827)	2.81652367
16	Abnormal hair whorl (HP:0010721)	2.78843946
17	Intestinal atresia (HP:0011100)	2.77630261
18	Vaginal atresia (HP:0000148)	2.69971603
19	Inability to walk (HP:0002540)	2.65387540
20	Papillary thyroid carcinoma (HP:0002895)	2.62703649
21	Widely spaced teeth (HP:0000687)	2.57951959
22	Pancreatic fibrosis (HP:0100732)	2.52642300
23	Chronic hepatic failure (HP:0100626)	2.51107261
24	Tubulointerstitial nephritis (HP:0001970)	2.49372552
25	Hip dysplasia (HP:0001385)	2.48151947
26	Lissencephaly (HP:0001339)	2.48023168
27	Abnormality of the astrocytes (HP:0100707)	2.45066635
28	Astrocytoma (HP:0009592)	2.45066635
29	Febrile seizures (HP:0002373)	2.44580772
30	Aqueductal stenosis (HP:0002410)	2.43709687
31	Broad-based gait (HP:0002136)	2.34613572
32	Abnormality of the hip-girdle musculature (HP:0001445)	2.33747607
33	Abnormality of the musculature of the pelvis (HP:0001469)	2.33747607
34	Submucous cleft hard palate (HP:0000176)	2.32272190
35	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.31483340
36	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.31483340
37	Poor coordination (HP:0002370)	2.31112503
38	Glioma (HP:0009733)	2.30671461
39	Neoplasm of the adrenal gland (HP:0100631)	2.24857419
40	Fair hair (HP:0002286)	2.24829185
41	Hypsarrhythmia (HP:0002521)	2.24171088
42	Type II lissencephaly (HP:0007260)	2.23374793
43	Renal cortical cysts (HP:0000803)	2.21581559
44	Cortical dysplasia (HP:0002539)	2.20238638
45	Protruding tongue (HP:0010808)	2.18657859
46	Optic nerve hypoplasia (HP:0000609)	2.17336332
47	Retinal dysplasia (HP:0007973)	2.16666100
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.15270122
49	Molar tooth sign on MRI (HP:0002419)	2.14288638
50	Abnormality of midbrain morphology (HP:0002418)	2.14288638
51	Abnormality of the corticospinal tract (HP:0002492)	2.14252053
52	Nephronophthisis (HP:0000090)	2.14146415
53	Methylmalonic acidemia (HP:0002912)	2.13450452
54	EEG with generalized epileptiform discharges (HP:0011198)	2.12906931
55	Hypothermia (HP:0002045)	2.11347728
56	Abnormality of the metopic suture (HP:0005556)	2.10971658
57	Ulnar claw (HP:0001178)	2.10777193
58	Cupped ear (HP:0000378)	2.08329354
59	Thyroid carcinoma (HP:0002890)	2.06302672
60	Epileptiform EEG discharges (HP:0011182)	2.05637747
61	Short tibia (HP:0005736)	2.04019660
62	Abnormality of the renal cortex (HP:0011035)	2.03451809
63	Pancreatic cysts (HP:0001737)	2.00540084
64	Thyroiditis (HP:0100646)	2.00501363
65	True hermaphroditism (HP:0010459)	2.00288624
66	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.98737086
67	Postaxial foot polydactyly (HP:0001830)	1.97333602
68	Impaired vibration sensation in the lower limbs (HP:0002166)	1.96656547
69	Urinary urgency (HP:0000012)	1.95918009
70	Medulloblastoma (HP:0002885)	1.94595234
71	Abnormality of salivation (HP:0100755)	1.91808046
72	Abnormality of the renal medulla (HP:0100957)	1.89173509
73	Septo-optic dysplasia (HP:0100842)	1.89155684
74	Specific learning disability (HP:0001328)	1.86322988
75	Narrow forehead (HP:0000341)	1.85307660
76	Polyphagia (HP:0002591)	1.85257984
77	Prominent metopic ridge (HP:0005487)	1.85105320
78	Postaxial hand polydactyly (HP:0001162)	1.84527504
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84388199
80	Focal motor seizures (HP:0011153)	1.84002822
81	Neoplasm of the oral cavity (HP:0100649)	1.83997378
82	Labial hypoplasia (HP:0000066)	1.81925325
83	Abolished electroretinogram (ERG) (HP:0000550)	1.81779139
84	Oligodactyly (hands) (HP:0001180)	1.80516179
85	Progressive cerebellar ataxia (HP:0002073)	1.79508338
86	Ependymoma (HP:0002888)	1.75668518
87	Broad foot (HP:0001769)	1.74741524
88	Pelvic girdle muscle weakness (HP:0003749)	1.73685041
89	Bifid tongue (HP:0010297)	1.72445769
90	Decreased lacrimation (HP:0000633)	1.69082489
91	Short foot (HP:0001773)	1.69040691
92	Shoulder girdle muscle weakness (HP:0003547)	1.68902222
93	Inappropriate behavior (HP:0000719)	1.68365736
94	Micropenis (HP:0000054)	1.65342900
95	Small hand (HP:0200055)	1.63989476
96	Abnormality of vitamin B metabolism (HP:0004340)	1.63960082
97	Generalized hypopigmentation of hair (HP:0011358)	1.63938752
98	Hypoplastic pelvis (HP:0008839)	1.62456182
99	Hemiparesis (HP:0001269)	1.61798511
100	Hypoplastic female external genitalia (HP:0012815)	1.61687801

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.91478535
2	TRIM28	3.88429733
3	BCR	3.78107135
4	FRK	3.54415579
5	MAP3K4	3.20116393
6	WNK3	2.93504670
7	CASK	2.62207453
8	EPHA4	2.56665939
9	MARK1	2.40216314
10	ERBB3	2.34800078
11	MAP2K7	2.25414577
12	BRD4	2.23794772
13	CSNK1G2	2.14618841
14	MAPK13	2.14359768
15	CSNK1G3	2.02998469
16	CSNK1A1L	2.01686260
17	AKT3	1.95039776
18	CSNK1G1	1.93768486
19	EIF2AK3	1.86498261
20	MKNK2	1.80048917
21	BMPR1B	1.58744546
22	NTRK3	1.50932777
23	EPHA3	1.50051516
24	ZAK	1.43742977
25	RPS6KA4	1.31164011
26	NUAK1	1.30417465
27	ADRBK2	1.23126275
28	STK38L	1.19311355
29	DYRK3	1.19260287
30	DYRK2	1.16611973
31	TSSK6	1.14528513
32	MKNK1	1.13304873
33	PLK3	1.11008425
34	SRPK1	1.10296103
35	PLK2	1.08582090
36	SGK2	1.07899780
37	TNIK	1.07621424
38	PAK3	1.02918126
39	MINK1	0.99461053
40	VRK1	0.97387239
41	PRKCE	0.93361023
42	BRSK2	0.90083166
43	FGFR2	0.85046495
44	ACVR1B	0.84151871
45	MAP2K4	0.84001218
46	EIF2AK1	0.77893803
47	OXSR1	0.76056550
48	PNCK	0.74734622
49	NLK	0.74295536
50	SIK3	0.73354181
51	SGK223	0.70814188
52	SGK494	0.70814188
53	BCKDK	0.68905056
54	INSRR	0.68240904
55	ATM	0.63338083
56	GRK1	0.62961096
57	NEK6	0.61988126
58	YES1	0.60880669
59	CSNK1D	0.59965939
60	OBSCN	0.59722863
61	DYRK1A	0.59141218
62	CDK5	0.56912041
63	PLK1	0.56525739
64	NTRK2	0.56184341
65	FER	0.56055018
66	UHMK1	0.54539910
67	PRKCG	0.53321650
68	IRAK1	0.51686438
69	TTK	0.50195560
70	STK39	0.48667946
71	IRAK2	0.47879407
72	MAP3K5	0.47607880
73	PIK3CA	0.45205306
74	CSNK1E	0.43813611
75	RPS6KA5	0.42222507
76	CSNK1A1	0.41680766
77	CAMK2A	0.41331133
78	CDK19	0.37900412
79	CAMK4	0.37072531
80	EGFR	0.36773942
81	MST4	0.36145020
82	PLK4	0.35724742
83	PRKCZ	0.34637380
84	ERBB4	0.31789284
85	ATR	0.31587986
86	PRKACB	0.31286501
87	CDK6	0.31283286
88	EIF2AK2	0.31232303
89	NEK1	0.29310798
90	CHUK	0.29123851
91	CAMKK2	0.28798198
92	CDK3	0.28363100
93	STK11	0.27120771
94	STK24	0.27008443
95	CAMK1G	0.26053134
96	GRK7	0.25831801
97	PRKG1	0.25099400
98	SGK3	0.25066818
99	FGFR1	0.24687023
100	CAMK2B	0.24268251

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.37976466
2	Protein export_Homo sapiens_hsa03060	2.66828261
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63646259
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.51748788
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.48377497
6	Circadian rhythm_Homo sapiens_hsa04710	2.34676848
7	Basal transcription factors_Homo sapiens_hsa03022	2.26069477
8	Phototransduction_Homo sapiens_hsa04744	2.25815275
9	Butanoate metabolism_Homo sapiens_hsa00650	2.12509212
10	Taste transduction_Homo sapiens_hsa04742	2.08548412
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.01774236
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.96692164
13	RNA degradation_Homo sapiens_hsa03018	1.94742764
14	GABAergic synapse_Homo sapiens_hsa04727	1.93132735
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.92450354
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.90356588
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.81615567
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.80188164
19	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.77667705
20	Propanoate metabolism_Homo sapiens_hsa00640	1.71983400
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64621981
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.63635564
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57920689
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.55666377
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53425101
26	Regulation of autophagy_Homo sapiens_hsa04140	1.52180364
27	Circadian entrainment_Homo sapiens_hsa04713	1.40434434
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.37007765
29	RNA transport_Homo sapiens_hsa03013	1.37002876
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.36899678
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35694370
32	Morphine addiction_Homo sapiens_hsa05032	1.33771884
33	Long-term depression_Homo sapiens_hsa04730	1.27455737
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24149066
35	mRNA surveillance pathway_Homo sapiens_hsa03015	1.21779809
36	RNA polymerase_Homo sapiens_hsa03020	1.19791090
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19637620
38	Amphetamine addiction_Homo sapiens_hsa05031	1.18118282
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.13791738
40	Oocyte meiosis_Homo sapiens_hsa04114	1.05527769
41	Alcoholism_Homo sapiens_hsa05034	1.00207095
42	Cocaine addiction_Homo sapiens_hsa05030	0.99203461
43	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.93513602
44	Peroxisome_Homo sapiens_hsa04146	0.92615603
45	Insulin secretion_Homo sapiens_hsa04911	0.90569663
46	Axon guidance_Homo sapiens_hsa04360	0.90238650
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85821311
48	Cell cycle_Homo sapiens_hsa04110	0.84999152
49	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.84458136
50	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81419366
51	Type II diabetes mellitus_Homo sapiens_hsa04930	0.80824134
52	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78497460
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.76614129
54	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.76258540
55	Serotonergic synapse_Homo sapiens_hsa04726	0.74311769
56	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.73921951
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73821640
58	p53 signaling pathway_Homo sapiens_hsa04115	0.72779910
59	Fatty acid elongation_Homo sapiens_hsa00062	0.71135816
60	Renin secretion_Homo sapiens_hsa04924	0.68972774
61	Mismatch repair_Homo sapiens_hsa03430	0.68840215
62	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.68177818
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67316822
64	Colorectal cancer_Homo sapiens_hsa05210	0.67028130
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63840027
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.63288735
67	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.62732936
68	Spliceosome_Homo sapiens_hsa03040	0.62720635
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.60803478
70	Wnt signaling pathway_Homo sapiens_hsa04310	0.60528530
71	Olfactory transduction_Homo sapiens_hsa04740	0.58704209
72	Folate biosynthesis_Homo sapiens_hsa00790	0.58523831
73	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58145311
74	FoxO signaling pathway_Homo sapiens_hsa04068	0.58135501
75	Nucleotide excision repair_Homo sapiens_hsa03420	0.57978066
76	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.54725617
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.54296512
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53233803
79	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53168608
80	Cholinergic synapse_Homo sapiens_hsa04725	0.51073993
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47790255
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47746490
83	Homologous recombination_Homo sapiens_hsa03440	0.46038888
84	mTOR signaling pathway_Homo sapiens_hsa04150	0.43462670
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.42998266
86	Lysine degradation_Homo sapiens_hsa00310	0.40547177
87	Adherens junction_Homo sapiens_hsa04520	0.39324258
88	Tight junction_Homo sapiens_hsa04530	0.36659992
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35050577
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34957481
91	Purine metabolism_Homo sapiens_hsa00230	0.34570588
92	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.31946418
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.31815606
94	Nitrogen metabolism_Homo sapiens_hsa00910	0.30406082
95	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.28740726
96	Melanoma_Homo sapiens_hsa05218	0.28033688
97	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.26901815
98	MicroRNAs in cancer_Homo sapiens_hsa05206	0.26773275
99	Huntingtons disease_Homo sapiens_hsa05016	0.25526187
100	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.25431672

ZNF484

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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