ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.80910756
2	epithelial cilium movement (GO:0003351)	5.76576036
3	axonemal dynein complex assembly (GO:0070286)	5.63845392
4	cilium movement (GO:0003341)	5.38274896
5	cilium or flagellum-dependent cell motility (GO:0001539)	4.58180266
6	platelet dense granule organization (GO:0060155)	4.44861433
7	regulation of cilium movement (GO:0003352)	4.42706456
8	axoneme assembly (GO:0035082)	4.37505178
9	protein localization to cilium (GO:0061512)	4.28241963
10	preassembly of GPI anchor in ER membrane (GO:0016254)	4.14242150
11	adaptation of signaling pathway (GO:0023058)	4.04297373
12	behavioral response to nicotine (GO:0035095)	3.95979000
13	DNA deamination (GO:0045006)	3.89679426
14	intraciliary transport (GO:0042073)	3.86077925
15	neural tube formation (GO:0001841)	3.82315316
16	response to pheromone (GO:0019236)	3.81178108
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.67720308
18	L-fucose catabolic process (GO:0042355)	3.62199766
19	fucose catabolic process (GO:0019317)	3.62199766
20	L-fucose metabolic process (GO:0042354)	3.62199766
21	GPI anchor metabolic process (GO:0006505)	3.53087929
22	respiratory chain complex IV assembly (GO:0008535)	3.51902327
23	retinal cone cell development (GO:0046549)	3.51635207
24	protein polyglutamylation (GO:0018095)	3.49995883
25	cilium organization (GO:0044782)	3.47397870
26	motile cilium assembly (GO:0044458)	3.42443414
27	cilium assembly (GO:0042384)	3.37222977
28	cilium morphogenesis (GO:0060271)	3.33599971
29	sperm motility (GO:0030317)	3.32679527
30	centriole replication (GO:0007099)	3.32042840
31	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.31875307
32	regulation of neurotransmitter uptake (GO:0051580)	3.29856618
33	GPI anchor biosynthetic process (GO:0006506)	3.23367101
34	photoreceptor cell maintenance (GO:0045494)	3.22605127
35	multicellular organism reproduction (GO:0032504)	3.19724635
36	cell wall macromolecule catabolic process (GO:0016998)	3.13763495
37	indolalkylamine metabolic process (GO:0006586)	3.07978885
38	cellular ketone body metabolic process (GO:0046950)	3.06760912
39	detection of light stimulus involved in sensory perception (GO:0050962)	3.02423341
40	detection of light stimulus involved in visual perception (GO:0050908)	3.02423341
41	keratinocyte development (GO:0003334)	2.93800159
42	tryptophan catabolic process (GO:0006569)	2.88380795
43	indole-containing compound catabolic process (GO:0042436)	2.88380795
44	indolalkylamine catabolic process (GO:0046218)	2.88380795
45	cytochrome complex assembly (GO:0017004)	2.84430475
46	C-terminal protein lipidation (GO:0006501)	2.83953082
47	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.82528176
48	ketone body metabolic process (GO:1902224)	2.82155474
49	C-terminal protein amino acid modification (GO:0018410)	2.81899226
50	sulfation (GO:0051923)	2.81256008
51	amine catabolic process (GO:0009310)	2.81005827
52	cellular biogenic amine catabolic process (GO:0042402)	2.81005827
53	gamma-aminobutyric acid transport (GO:0015812)	2.80868599
54	cell wall macromolecule metabolic process (GO:0044036)	2.79268069
55	mannosylation (GO:0097502)	2.78380696
56	ubiquinone biosynthetic process (GO:0006744)	2.76518250
57	nonmotile primary cilium assembly (GO:0035058)	2.76068830
58	protein complex biogenesis (GO:0070271)	2.74240900
59	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.72998736
60	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.72998736
61	NADH dehydrogenase complex assembly (GO:0010257)	2.72998736
62	piRNA metabolic process (GO:0034587)	2.72276387
63	neuron fate determination (GO:0048664)	2.69858822
64	cytidine metabolic process (GO:0046087)	2.67229442
65	cytidine catabolic process (GO:0006216)	2.67229442
66	cytidine deamination (GO:0009972)	2.67229442
67	peptidyl-histidine modification (GO:0018202)	2.66437471
68	transmission of nerve impulse (GO:0019226)	2.61707216
69	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.61667925
70	behavioral response to ethanol (GO:0048149)	2.60286693
71	regulation of microtubule-based movement (GO:0060632)	2.60150469
72	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.59132436
73	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.59132436
74	cellular component assembly involved in morphogenesis (GO:0010927)	2.57961046
75	axon ensheathment in central nervous system (GO:0032291)	2.55293257
76	central nervous system myelination (GO:0022010)	2.55293257
77	ubiquinone metabolic process (GO:0006743)	2.54094915
78	smoothened signaling pathway (GO:0007224)	2.53570749
79	proline transport (GO:0015824)	2.52010144
80	male meiosis (GO:0007140)	2.50485202
81	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.50444513
82	dopamine transport (GO:0015872)	2.50118928
83	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49874145
84	S-adenosylmethionine metabolic process (GO:0046500)	2.48286627
85	neuronal action potential (GO:0019228)	2.47800937
86	determination of left/right symmetry (GO:0007368)	2.47646575
87	regulation of oligodendrocyte differentiation (GO:0048713)	2.47255547
88	parental behavior (GO:0060746)	2.47250469
89	synaptic transmission, cholinergic (GO:0007271)	2.45076916
90	water-soluble vitamin biosynthetic process (GO:0042364)	2.42634876
91	left/right axis specification (GO:0070986)	2.42344873
92	glycolipid biosynthetic process (GO:0009247)	2.42174106
93	protein K11-linked deubiquitination (GO:0035871)	2.41981001
94	kynurenine metabolic process (GO:0070189)	2.40942047
95	exogenous drug catabolic process (GO:0042738)	2.40779473
96	mitochondrial respiratory chain complex assembly (GO:0033108)	2.40503336
97	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.39976926
98	protein-cofactor linkage (GO:0018065)	2.37035005
99	somite development (GO:0061053)	2.36328209
100	embryonic epithelial tube formation (GO:0001838)	2.36160579

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54505619
2	VDR_22108803_ChIP-Seq_LS180_Human	3.35299072
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.86186976
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70400723
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.59104653
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.44717699
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37579773
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33663193
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31095789
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29244716
11	FUS_26573619_Chip-Seq_HEK293_Human	2.25101329
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23743760
13	P300_19829295_ChIP-Seq_ESCs_Human	2.12296515
14	EWS_26573619_Chip-Seq_HEK293_Human	2.11947898
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10093584
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.97377909
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90984625
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81242577
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.79667366
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.77068741
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76184921
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76085012
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.75471402
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.70645408
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67325510
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.66766107
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64499446
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60673128
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.54837482
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54837482
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52153692
32	AR_25329375_ChIP-Seq_VCAP_Human	1.51044247
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.50843202
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49281471
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49281471
36	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49012166
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48811050
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48804200
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47155297
40	STAT3_23295773_ChIP-Seq_U87_Human	1.46965363
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46556099
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.42089492
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39052619
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38601195
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.37695078
46	TCF4_23295773_ChIP-Seq_U87_Human	1.37510727
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36073085
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36073085
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34711566
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34306795
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34306795
52	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32778262
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32107132
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31886173
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31814411
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31586591
57	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31216141
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30759148
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30063608
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28789894
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.24504382
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.23001412
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22576735
64	* CDX2_22108803_ChIP-Seq_LS180_Human	1.22453127
65	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.20793778
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20756115
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19048113
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18233572
69	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.18143788
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.17965117
71	AR_20517297_ChIP-Seq_VCAP_Human	1.17758615
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17289851
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17159003
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16542738
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15662709
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15541843
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14539419
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14360909
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.12421184
80	GATA3_26560356_Chip-Seq_TH2_Human	1.10996524
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10943176
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10887260
83	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10404306
84	NCOR_22424771_ChIP-Seq_293T_Human	1.09617830
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09396214
86	JUN_21703547_ChIP-Seq_K562_Human	1.08874870
87	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.08086475
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03895820
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03260827
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02378949
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.99959266
92	* HOXB7_26014856_ChIP-Seq_BT474_Human	0.99475161
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99230797
94	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98952796
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.98853132
96	VDR_23849224_ChIP-Seq_CD4+_Human	0.98698997
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.98606494
98	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98140535
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97353714
100	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96612574

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.95473560
2	MP0003195_calcinosis	2.67964205
3	MP0003136_yellow_coat_color	2.50907417
4	MP0002102_abnormal_ear_morphology	2.39626857
5	MP0006292_abnormal_olfactory_placode	2.39554633
6	MP0005551_abnormal_eye_electrophysiolog	2.33087129
7	MP0003646_muscle_fatigue	2.27688685
8	MP0002653_abnormal_ependyma_morphology	2.27450260
9	MP0004043_abnormal_pH_regulation	2.25264787
10	MP0001986_abnormal_taste_sensitivity	2.18724276
11	MP0005645_abnormal_hypothalamus_physiol	2.11516044
12	MP0008875_abnormal_xenobiotic_pharmacok	2.09093519
13	MP0008872_abnormal_physiological_respon	2.07950324
14	MP0000569_abnormal_digit_pigmentation	2.07007156
15	MP0005174_abnormal_tail_pigmentation	1.99120975
16	MP0006072_abnormal_retinal_apoptosis	1.97638866
17	MP0008995_early_reproductive_senescence	1.94273908
18	MP0001968_abnormal_touch/_nociception	1.87666741
19	MP0003011_delayed_dark_adaptation	1.85397843
20	MP0005253_abnormal_eye_physiology	1.78200753
21	MP0000372_irregular_coat_pigmentation	1.77871014
22	MP0002638_abnormal_pupillary_reflex	1.76874176
23	MP0002163_abnormal_gland_morphology	1.74806146
24	MP0004885_abnormal_endolymph	1.73836983
25	MP0009046_muscle_twitch	1.68869613
26	MP0002876_abnormal_thyroid_physiology	1.68466600
27	MP0002736_abnormal_nociception_after	1.66017639
28	MP0002928_abnormal_bile_duct	1.65757651
29	MP0005410_abnormal_fertilization	1.64309278
30	MP0004142_abnormal_muscle_tone	1.61921527
31	MP0009745_abnormal_behavioral_response	1.59484284
32	MP0005646_abnormal_pituitary_gland	1.58431184
33	MP0001984_abnormal_olfaction	1.58115289
34	MP0002837_dystrophic_cardiac_calcinosis	1.54747013
35	MP0003878_abnormal_ear_physiology	1.52643782
36	MP0005377_hearing/vestibular/ear_phenot	1.52643782
37	MP0002234_abnormal_pharynx_morphology	1.52374032
38	MP0002272_abnormal_nervous_system	1.51009224
39	MP0002277_abnormal_respiratory_mucosa	1.47652984
40	MP0000631_abnormal_neuroendocrine_gland	1.47192911
41	MP0005084_abnormal_gallbladder_morpholo	1.39242573
42	MP0001486_abnormal_startle_reflex	1.31937614
43	MP0000516_abnormal_urinary_system	1.31347055
44	MP0005367_renal/urinary_system_phenotyp	1.31347055
45	MP0005379_endocrine/exocrine_gland_phen	1.28480444
46	MP0001485_abnormal_pinna_reflex	1.26324820
47	MP0000427_abnormal_hair_cycle	1.24310571
48	MP0001501_abnormal_sleep_pattern	1.22748009
49	MP0004133_heterotaxia	1.22257995
50	MP0005389_reproductive_system_phenotype	1.22139469
51	MP0008057_abnormal_DNA_replication	1.19840648
52	MP0001919_abnormal_reproductive_system	1.16596148
53	MP0009764_decreased_sensitivity_to	1.16057576
54	MP0010368_abnormal_lymphatic_system	1.09655399
55	MP0001764_abnormal_homeostasis	1.09426389
56	MP0002938_white_spotting	1.09055839
57	MP0001970_abnormal_pain_threshold	1.08573004
58	MP0000015_abnormal_ear_pigmentation	1.08207285
59	MP0003718_maternal_effect	1.08158570
60	MP0008789_abnormal_olfactory_epithelium	1.06852947
61	MP0005195_abnormal_posterior_eye	1.02194311
62	MP0001929_abnormal_gametogenesis	1.01888844
63	MP0002095_abnormal_skin_pigmentation	1.00001523
64	MP0002751_abnormal_autonomic_nervous	0.99933143
65	MP0004742_abnormal_vestibular_system	0.99697186
66	MP0002572_abnormal_emotion/affect_behav	0.98107672
67	MP0006276_abnormal_autonomic_nervous	0.97976107
68	MP0000026_abnormal_inner_ear	0.94396122
69	MP0003786_premature_aging	0.93619482
70	MP0002735_abnormal_chemical_nociception	0.93072510
71	MP0003698_abnormal_male_reproductive	0.93007252
72	MP0001905_abnormal_dopamine_level	0.92587165
73	MP0001324_abnormal_eye_pigmentation	0.89240266
74	MP0003724_increased_susceptibility_to	0.88879892
75	MP0005075_abnormal_melanosome_morpholog	0.87144246
76	MP0003880_abnormal_central_pattern	0.86552303
77	MP0004145_abnormal_muscle_electrophysio	0.85279324
78	MP0008058_abnormal_DNA_repair	0.84593290
79	MP0002160_abnormal_reproductive_system	0.82296776
80	MP0001293_anophthalmia	0.81361100
81	MP0002557_abnormal_social/conspecific_i	0.80592855
82	MP0002067_abnormal_sensory_capabilities	0.79043046
83	MP0002282_abnormal_trachea_morphology	0.78322898
84	MP0005671_abnormal_response_to	0.78134233
85	MP0001440_abnormal_grooming_behavior	0.76562294
86	MP0005085_abnormal_gallbladder_physiolo	0.76548786
87	MP0010386_abnormal_urinary_bladder	0.76218041
88	MP0000230_abnormal_systemic_arterial	0.75998213
89	MP0005167_abnormal_blood-brain_barrier	0.75439118
90	MP0001963_abnormal_hearing_physiology	0.75106841
91	MP0002229_neurodegeneration	0.74548633
92	MP0003787_abnormal_imprinting	0.74047942
93	MP0004147_increased_porphyrin_level	0.73405851
94	MP0002064_seizures	0.72863485
95	MP0002752_abnormal_somatic_nervous	0.71945904
96	MP0003122_maternal_imprinting	0.71873945
97	MP0001529_abnormal_vocalization	0.70264608
98	MP0005423_abnormal_somatic_nervous	0.68662608
99	MP0000653_abnormal_sex_gland	0.66885066
100	MP0004883_abnormal_blood_vessel	0.66661824

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.02648560
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.91152368
3	Absent/shortened dynein arms (HP:0200106)	4.91152368
4	True hermaphroditism (HP:0010459)	4.65012259
5	Abnormal respiratory motile cilium morphology (HP:0005938)	4.53922338
6	Abnormal respiratory epithelium morphology (HP:0012253)	4.53922338
7	Pancreatic cysts (HP:0001737)	4.47781559
8	Abnormal respiratory motile cilium physiology (HP:0012261)	4.42122010
9	Abnormal ciliary motility (HP:0012262)	4.30152829
10	Pancreatic fibrosis (HP:0100732)	4.16204437
11	Molar tooth sign on MRI (HP:0002419)	3.78197115
12	Abnormality of midbrain morphology (HP:0002418)	3.78197115
13	Rhinitis (HP:0012384)	3.58082800
14	Nephronophthisis (HP:0000090)	3.49493896
15	Tubulointerstitial nephritis (HP:0001970)	3.39342871
16	Medial flaring of the eyebrow (HP:0010747)	3.27683643
17	Chronic hepatic failure (HP:0100626)	3.23805635
18	Congenital stationary night blindness (HP:0007642)	3.03276351
19	Abnormality of the renal medulla (HP:0100957)	2.93968520
20	Congenital primary aphakia (HP:0007707)	2.85932020
21	Gait imbalance (HP:0002141)	2.85734102
22	Cystic liver disease (HP:0006706)	2.79865820
23	Chronic bronchitis (HP:0004469)	2.76892251
24	Bronchiectasis (HP:0002110)	2.74920796
25	Hyperventilation (HP:0002883)	2.70234619
26	Decreased central vision (HP:0007663)	2.69552395
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.67244798
28	Nephrogenic diabetes insipidus (HP:0009806)	2.63292395
29	Male pseudohermaphroditism (HP:0000037)	2.60615170
30	Abnormality of the renal cortex (HP:0011035)	2.54520853
31	Sclerocornea (HP:0000647)	2.50659263
32	Abolished electroretinogram (ERG) (HP:0000550)	2.49230012
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.47368923
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.45048781
35	Occipital encephalocele (HP:0002085)	2.44982312
36	Type II lissencephaly (HP:0007260)	2.44878869
37	Attenuation of retinal blood vessels (HP:0007843)	2.36621050
38	Large for gestational age (HP:0001520)	2.33917923
39	Concave nail (HP:0001598)	2.33444561
40	Tubular atrophy (HP:0000092)	2.32064573
41	Gaze-evoked nystagmus (HP:0000640)	2.29199897
42	Postaxial foot polydactyly (HP:0001830)	2.28985776
43	Genital tract atresia (HP:0001827)	2.27651840
44	Progressive cerebellar ataxia (HP:0002073)	2.26180521
45	Methylmalonic acidemia (HP:0002912)	2.25285045
46	Vaginal atresia (HP:0000148)	2.24896971
47	Inability to walk (HP:0002540)	2.17311116
48	Furrowed tongue (HP:0000221)	2.17061858
49	Stomach cancer (HP:0012126)	2.16033937
50	Polydipsia (HP:0001959)	2.13489280
51	Abnormal drinking behavior (HP:0030082)	2.13489280
52	Anencephaly (HP:0002323)	2.09726778
53	Abnormality of macular pigmentation (HP:0008002)	2.06468027
54	Chronic sinusitis (HP:0011109)	2.03285194
55	Congenital hepatic fibrosis (HP:0002612)	2.02938114
56	Acute necrotizing encephalopathy (HP:0006965)	2.02028904
57	Stomatitis (HP:0010280)	2.00387005
58	Renal cortical cysts (HP:0000803)	1.96948854
59	Bronchitis (HP:0012387)	1.95673542
60	Febrile seizures (HP:0002373)	1.95248325
61	Congenital, generalized hypertrichosis (HP:0004540)	1.94761501
62	Poor coordination (HP:0002370)	1.94609872
63	Hepatocellular necrosis (HP:0001404)	1.93020970
64	Postaxial hand polydactyly (HP:0001162)	1.90494083
65	Optic nerve hypoplasia (HP:0000609)	1.89982091
66	Progressive macrocephaly (HP:0004481)	1.88217234
67	Bile duct proliferation (HP:0001408)	1.87957768
68	Abnormal biliary tract physiology (HP:0012439)	1.87957768
69	Tubulointerstitial abnormality (HP:0001969)	1.87487927
70	Ketoacidosis (HP:0001993)	1.85685196
71	Acute encephalopathy (HP:0006846)	1.84726575
72	Mitochondrial inheritance (HP:0001427)	1.84434471
73	Keratoconus (HP:0000563)	1.83491582
74	Increased corneal curvature (HP:0100692)	1.83491582
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.82300909
76	Cerebellar dysplasia (HP:0007033)	1.81783358
77	Fair hair (HP:0002286)	1.80822727
78	Methylmalonic aciduria (HP:0012120)	1.79641709
79	Hepatic necrosis (HP:0002605)	1.78135089
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77822362
81	Bony spicule pigmentary retinopathy (HP:0007737)	1.77497669
82	Thyroiditis (HP:0100646)	1.77186958
83	Optic disc pallor (HP:0000543)	1.76688798
84	Hyperglycinemia (HP:0002154)	1.74683347
85	Increased CSF lactate (HP:0002490)	1.73616637
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73540645
87	Focal motor seizures (HP:0011153)	1.73069367
88	Septo-optic dysplasia (HP:0100842)	1.72864023
89	Broad-based gait (HP:0002136)	1.71006150
90	Clumsiness (HP:0002312)	1.70441914
91	Absent speech (HP:0001344)	1.70214908
92	Hypoproteinemia (HP:0003075)	1.70194957
93	Hemiparesis (HP:0001269)	1.69537350
94	Progressive inability to walk (HP:0002505)	1.69361996
95	Abnormal mitochondria in muscle tissue (HP:0008316)	1.68410609
96	Narrow forehead (HP:0000341)	1.67397297
97	Atonic seizures (HP:0010819)	1.67038384
98	Infertility (HP:0000789)	1.66348830
99	Retinitis pigmentosa (HP:0000510)	1.65386673
100	Polyuria (HP:0000103)	1.64534202

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.40125834
2	ADRBK2	3.12246363
3	MAP4K2	3.06651618
4	WNK4	2.76451246
5	MAPK13	2.45262197
6	WNK3	2.35751378
7	STK24	2.28174728
8	BMPR1B	2.27931317
9	MAPK15	2.26564941
10	TIE1	2.21548401
11	GRK1	2.20036025
12	STK39	2.19299500
13	PINK1	2.17623406
14	ZAK	2.12169453
15	INSRR	2.10902325
16	PNCK	1.99811928
17	NUAK1	1.85493107
18	MST4	1.80154963
19	CASK	1.69792741
20	TEC	1.67147157
21	TRIM28	1.48839515
22	ACVR1B	1.44251765
23	TLK1	1.33357008
24	TAOK3	1.24856053
25	STK38L	1.22679897
26	MAP3K12	1.22001338
27	WNK1	1.17758659
28	MKNK2	1.12489718
29	PAK3	1.11180930
30	OXSR1	1.08807793
31	PRKCE	1.08746697
32	VRK1	1.07025396
33	BCR	1.06798554
34	TXK	1.06660973
35	MAPKAPK3	1.05340872
36	MAP3K4	1.05103774
37	ERBB3	1.02907395
38	PRKCQ	1.00032438
39	ADRBK1	0.99208245
40	PTK2B	0.99034485
41	AKT3	0.91842569
42	KIT	0.88965125
43	PLK2	0.87784878
44	PIK3CA	0.87727387
45	CSNK1G3	0.84585638
46	CSNK1G2	0.83965704
47	BMPR2	0.83927288
48	CSNK1G1	0.81971131
49	WEE1	0.79459030
50	DYRK2	0.76997451
51	NTRK3	0.76944001
52	DAPK2	0.74680319
53	TNIK	0.74470189
54	PRKCG	0.73114161
55	TNK2	0.69506998
56	ITK	0.67948664
57	BCKDK	0.67491046
58	IKBKB	0.66802636
59	CSNK1A1L	0.66517289
60	PLK4	0.66423101
61	EIF2AK3	0.64656982
62	MAP3K2	0.62848856
63	BRSK2	0.61247321
64	MARK3	0.59897619
65	GRK6	0.56603200
66	TGFBR1	0.53575833
67	PLK3	0.52997687
68	MKNK1	0.52938210
69	MAP2K7	0.51026302
70	JAK3	0.47712514
71	PRKACA	0.46529704
72	CCNB1	0.46525439
73	SYK	0.46410757
74	IKBKE	0.43907585
75	EPHA4	0.43574567
76	ABL1	0.42438342
77	PKN1	0.39529802
78	PIK3CG	0.39480878
79	PHKG1	0.39373716
80	PHKG2	0.39373716
81	DYRK3	0.39213782
82	FGFR2	0.38652351
83	CAMKK2	0.36788614
84	EPHA3	0.36153288
85	PRKCI	0.36022692
86	IGF1R	0.35840280
87	PRKCA	0.35365034
88	PRKG1	0.34344150
89	VRK2	0.34202408
90	CAMK2A	0.34133990
91	STK16	0.32333842
92	LYN	0.32158823
93	STK3	0.31983816
94	SGK2	0.31969332
95	MINK1	0.31283933
96	RPS6KA5	0.30563426
97	FER	0.30364666
98	PRKCZ	0.30239286
99	DYRK1A	0.28829500
100	CSNK1A1	0.27770662

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.95322254
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.65221604
3	Protein export_Homo sapiens_hsa03060	2.64711182
4	Phototransduction_Homo sapiens_hsa04744	2.45122899
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.30878512
6	Asthma_Homo sapiens_hsa05310	2.14576774
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10359935
8	Butanoate metabolism_Homo sapiens_hsa00650	2.04380635
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.03000224
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.89995879
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89563236
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89358184
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.87349676
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.83932399
15	Regulation of autophagy_Homo sapiens_hsa04140	1.78459340
16	Propanoate metabolism_Homo sapiens_hsa00640	1.76848965
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73795591
18	Allograft rejection_Homo sapiens_hsa05330	1.71199392
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.62373708
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59046706
21	Parkinsons disease_Homo sapiens_hsa05012	1.56738674
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.56642363
23	Basal transcription factors_Homo sapiens_hsa03022	1.56023565
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.55836025
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.55720474
26	Peroxisome_Homo sapiens_hsa04146	1.55421523
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.55239602
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.53934949
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51656170
30	Homologous recombination_Homo sapiens_hsa03440	1.51297808
31	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.41596566
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39294456
33	Olfactory transduction_Homo sapiens_hsa04740	1.36907595
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.35356203
35	Huntingtons disease_Homo sapiens_hsa05016	1.30913911
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30595959
37	Caffeine metabolism_Homo sapiens_hsa00232	1.29221119
38	Nicotine addiction_Homo sapiens_hsa05033	1.28158145
39	Primary immunodeficiency_Homo sapiens_hsa05340	1.27054118
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.26656533
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.22215640
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.20967392
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.19937880
44	Taste transduction_Homo sapiens_hsa04742	1.18401805
45	Non-homologous end-joining_Homo sapiens_hsa03450	1.18259461
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12972405
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.11620909
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10112631
49	Ether lipid metabolism_Homo sapiens_hsa00565	1.09626240
50	Retinol metabolism_Homo sapiens_hsa00830	1.09458195
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08580376
52	RNA polymerase_Homo sapiens_hsa03020	1.04910468
53	Morphine addiction_Homo sapiens_hsa05032	0.96952417
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.95531122
55	Proteasome_Homo sapiens_hsa03050	0.93115390
56	Alzheimers disease_Homo sapiens_hsa05010	0.91990085
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91149118
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89919655
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87906429
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87596301
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.86262044
62	Salivary secretion_Homo sapiens_hsa04970	0.84666734
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80542406
64	RNA degradation_Homo sapiens_hsa03018	0.78065607
65	ABC transporters_Homo sapiens_hsa02010	0.77429483
66	Circadian entrainment_Homo sapiens_hsa04713	0.73448558
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.72050088
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70737458
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70626777
70	Glutathione metabolism_Homo sapiens_hsa00480	0.68548048
71	GABAergic synapse_Homo sapiens_hsa04727	0.68429546
72	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.63818222
73	Serotonergic synapse_Homo sapiens_hsa04726	0.63535272
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61118305
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.60195663
76	Insulin secretion_Homo sapiens_hsa04911	0.58744488
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57640150
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57032597
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56417122
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55988425
81	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.54860771
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52911692
83	African trypanosomiasis_Homo sapiens_hsa05143	0.52573515
84	Purine metabolism_Homo sapiens_hsa00230	0.52442873
85	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.52038428
86	Metabolic pathways_Homo sapiens_hsa01100	0.51958684
87	Fatty acid degradation_Homo sapiens_hsa00071	0.49749073
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.49595363
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48875940
90	Circadian rhythm_Homo sapiens_hsa04710	0.48610250
91	Fatty acid elongation_Homo sapiens_hsa00062	0.46379865
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.43982397
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.40230321
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.39436434
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38508148
96	Histidine metabolism_Homo sapiens_hsa00340	0.35730554
97	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35538797
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.34770005
99	Mineral absorption_Homo sapiens_hsa04978	0.33435871
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.31043291

ZNF487

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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