ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.56983999
2	fucose catabolic process (GO:0019317)	4.38535601
3	L-fucose metabolic process (GO:0042354)	4.38535601
4	L-fucose catabolic process (GO:0042355)	4.38535601
5	piRNA metabolic process (GO:0034587)	4.22589044
6	regulation of meiosis I (GO:0060631)	3.89311693
7	synapsis (GO:0007129)	3.81306939
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.75844783
9	DNA deamination (GO:0045006)	3.75684148
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.59137199
11	response to pheromone (GO:0019236)	3.40314471
12	protein-cofactor linkage (GO:0018065)	3.40184137
13	protein K6-linked ubiquitination (GO:0085020)	3.38584427
14	indolalkylamine metabolic process (GO:0006586)	3.38020585
15	indole-containing compound catabolic process (GO:0042436)	3.34798361
16	indolalkylamine catabolic process (GO:0046218)	3.34798361
17	tryptophan catabolic process (GO:0006569)	3.34798361
18	kynurenine metabolic process (GO:0070189)	3.33297404
19	replication fork processing (GO:0031297)	3.32439472
20	reciprocal meiotic recombination (GO:0007131)	3.24848813
21	reciprocal DNA recombination (GO:0035825)	3.24848813
22	recombinational repair (GO:0000725)	3.22857356
23	double-strand break repair via homologous recombination (GO:0000724)	3.21283185
24	male meiosis I (GO:0007141)	3.19836193
25	meiotic chromosome segregation (GO:0045132)	3.16174940
26	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.10808775
27	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.08403352
28	cornea development in camera-type eye (GO:0061303)	3.05905280
29	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.01515523
30	protein complex biogenesis (GO:0070271)	2.99925831
31	DNA double-strand break processing (GO:0000729)	2.99908221
32	tryptophan metabolic process (GO:0006568)	2.98944482
33	reflex (GO:0060004)	2.98927861
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.98522107
35	NADH dehydrogenase complex assembly (GO:0010257)	2.98522107
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.98522107
37	DNA methylation involved in gamete generation (GO:0043046)	2.98302042
38	neural tube formation (GO:0001841)	2.95424454
39	sulfation (GO:0051923)	2.91594515
40	platelet dense granule organization (GO:0060155)	2.90812421
41	regulation of DNA endoreduplication (GO:0032875)	2.89972439
42	positive regulation of meiosis (GO:0045836)	2.86886909
43	nonmotile primary cilium assembly (GO:0035058)	2.86233430
44	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85777141
45	retinal cone cell development (GO:0046549)	2.79185084
46	respiratory chain complex IV assembly (GO:0008535)	2.78179292
47	photoreceptor cell maintenance (GO:0045494)	2.74933113
48	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74208609
49	regulation of hippo signaling (GO:0035330)	2.73989122
50	limb bud formation (GO:0060174)	2.73277637
51	axoneme assembly (GO:0035082)	2.72604191
52	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.72262487
53	negative regulation of telomere maintenance (GO:0032205)	2.71853761
54	male meiosis (GO:0007140)	2.70734216
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70536119
56	positive regulation of meiotic cell cycle (GO:0051446)	2.69202331
57	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.68970399
58	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.68970399
59	negative regulation of mast cell activation (GO:0033004)	2.68693512
60	resolution of meiotic recombination intermediates (GO:0000712)	2.68469642
61	detection of light stimulus involved in visual perception (GO:0050908)	2.68294646
62	detection of light stimulus involved in sensory perception (GO:0050962)	2.68294646
63	indole-containing compound metabolic process (GO:0042430)	2.65671765
64	cell proliferation in forebrain (GO:0021846)	2.65412986
65	epithelial cilium movement (GO:0003351)	2.63567425
66	behavioral response to ethanol (GO:0048149)	2.61845223
67	cellular response to ATP (GO:0071318)	2.61794519
68	photoreceptor cell development (GO:0042461)	2.60049807
69	nephron epithelium morphogenesis (GO:0072088)	2.59107793
70	nephron tubule morphogenesis (GO:0072078)	2.59107793
71	cilium morphogenesis (GO:0060271)	2.58876022
72	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.58799721
73	meiosis I (GO:0007127)	2.58544615
74	negative regulation of systemic arterial blood pressure (GO:0003085)	2.56309646
75	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.55488580
76	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.54603749
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.54603749
78	auditory receptor cell stereocilium organization (GO:0060088)	2.54476966
79	centriole replication (GO:0007099)	2.53250890
80	protein polyglutamylation (GO:0018095)	2.51394169
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.50468674
82	rhodopsin mediated signaling pathway (GO:0016056)	2.50117168
83	cytochrome complex assembly (GO:0017004)	2.49750726
84	histone H2A acetylation (GO:0043968)	2.49467761
85	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.48827527
86	hindbrain development (GO:0030902)	2.48361451
87	protein K11-linked deubiquitination (GO:0035871)	2.45363633
88	somite development (GO:0061053)	2.44861939
89	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.44379220
90	regulation of action potential (GO:0098900)	2.44177028
91	cilium organization (GO:0044782)	2.41780562
92	primary amino compound metabolic process (GO:1901160)	2.41300765
93	regulation of male gonad development (GO:2000018)	2.40877128
94	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.40683135
95	pseudouridine synthesis (GO:0001522)	2.40165310
96	embryonic epithelial tube formation (GO:0001838)	2.39494624
97	negative regulation by host of viral transcription (GO:0043922)	2.38918014
98	regulation of mesoderm development (GO:2000380)	2.38425030
99	gamma-aminobutyric acid transport (GO:0015812)	2.38340108
100	isotype switching (GO:0045190)	2.38173747

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	4.07658788
2	VDR_22108803_ChIP-Seq_LS180_Human	3.62634895
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.76357574
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.72382214
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.62489387
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.56055893
7	EWS_26573619_Chip-Seq_HEK293_Human	2.55141220
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51718438
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.48370938
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.43655117
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40983908
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38840089
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.35214411
14	FUS_26573619_Chip-Seq_HEK293_Human	2.33562849
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.29942098
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.27172140
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14283342
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07641446
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.05070876
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.01520825
21	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00517704
22	P300_19829295_ChIP-Seq_ESCs_Human	1.99394718
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.97136822
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.96228084
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.95784828
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.94716286
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.93729622
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.88572846
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83931936
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76481109
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69417078
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.66205576
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.62679526
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57697312
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.57444309
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54559632
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.52852060
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51811016
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.50174634
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48020567
41	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40754159
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40497862
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40460880
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.40460880
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.40228811
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39683028
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39683028
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38689201
49	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.37288706
50	STAT3_23295773_ChIP-Seq_U87_Human	1.36086307
51	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35561048
52	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.34802572
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34288529
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34288529
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34187976
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33959675
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31533310
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31244471
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31185096
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30423102
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29232934
62	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28348139
63	AR_25329375_ChIP-Seq_VCAP_Human	1.28282658
64	TCF4_23295773_ChIP-Seq_U87_Human	1.28059637
65	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27881708
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24846922
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.23725108
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19152700
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18928391
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18928391
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18877764
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17903206
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17750348
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17280738
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16851684
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.13896062
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13210940
78	NCOR_22424771_ChIP-Seq_293T_Human	1.12119762
79	AR_20517297_ChIP-Seq_VCAP_Human	1.11903871
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11040054
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09630081
82	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08915529
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08466176
84	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.07778174
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06841000
86	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04441134
87	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.04333563
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04293793
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00988303
90	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98241435
91	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.97526028
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96175442
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96036642
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96024635
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95493200
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94017854
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93741923
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.93434113
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93107906
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.92598614

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.98377204
2	MP0002102_abnormal_ear_morphology	2.70797951
3	MP0005551_abnormal_eye_electrophysiolog	2.55315585
4	MP0003136_yellow_coat_color	2.39093333
5	MP0001485_abnormal_pinna_reflex	2.32853731
6	MP0001968_abnormal_touch/_nociception	2.31756048
7	MP0006292_abnormal_olfactory_placode	2.28691438
8	MP0004885_abnormal_endolymph	2.27651252
9	MP0003195_calcinosis	2.18595993
10	MP0008872_abnormal_physiological_respon	2.15557335
11	MP0002837_dystrophic_cardiac_calcinosis	2.11938530
12	MP0005084_abnormal_gallbladder_morpholo	2.03753421
13	MP0001986_abnormal_taste_sensitivity	2.03261742
14	MP0002736_abnormal_nociception_after	1.99545355
15	MP0004147_increased_porphyrin_level	1.97690528
16	MP0006072_abnormal_retinal_apoptosis	1.97383271
17	MP0003011_delayed_dark_adaptation	1.97279654
18	MP0002876_abnormal_thyroid_physiology	1.94861847
19	MP0000569_abnormal_digit_pigmentation	1.89670200
20	MP0002160_abnormal_reproductive_system	1.82139945
21	MP0002638_abnormal_pupillary_reflex	1.80310913
22	MP0005253_abnormal_eye_physiology	1.78460334
23	MP0005646_abnormal_pituitary_gland	1.76136400
24	MP0003646_muscle_fatigue	1.72953840
25	MP0000372_irregular_coat_pigmentation	1.72274016
26	MP0004742_abnormal_vestibular_system	1.71541130
27	MP0002938_white_spotting	1.70364698
28	MP0010094_abnormal_chromosome_stability	1.69215989
29	MP0000631_abnormal_neuroendocrine_gland	1.66437516
30	MP0002653_abnormal_ependyma_morphology	1.64785082
31	MP0005645_abnormal_hypothalamus_physiol	1.63363506
32	MP0009745_abnormal_behavioral_response	1.60898855
33	MP0005389_reproductive_system_phenotype	1.60271249
34	MP0010386_abnormal_urinary_bladder	1.58159894
35	MP0000427_abnormal_hair_cycle	1.51432495
36	MP0008058_abnormal_DNA_repair	1.49091699
37	MP0008875_abnormal_xenobiotic_pharmacok	1.46505130
38	MP0003880_abnormal_central_pattern	1.44055543
39	MP0001529_abnormal_vocalization	1.43878147
40	MP0002138_abnormal_hepatobiliary_system	1.42883097
41	MP0003718_maternal_effect	1.40801298
42	MP0002735_abnormal_chemical_nociception	1.38612081
43	MP0004142_abnormal_muscle_tone	1.38505828
44	MP0002751_abnormal_autonomic_nervous	1.38224234
45	MP0004133_heterotaxia	1.35709691
46	MP0002272_abnormal_nervous_system	1.33645717
47	MP0003890_abnormal_embryonic-extraembry	1.32843112
48	MP0001919_abnormal_reproductive_system	1.31143986
49	MP0002928_abnormal_bile_duct	1.30914524
50	MP0002163_abnormal_gland_morphology	1.28924387
51	MP0009046_muscle_twitch	1.28114619
52	MP0001501_abnormal_sleep_pattern	1.28105079
53	MP0005174_abnormal_tail_pigmentation	1.25261427
54	MP0001486_abnormal_startle_reflex	1.19813078
55	MP0005377_hearing/vestibular/ear_phenot	1.18058126
56	MP0003878_abnormal_ear_physiology	1.18058126
57	MP0002210_abnormal_sex_determination	1.16361834
58	MP0002277_abnormal_respiratory_mucosa	1.16278451
59	MP0004215_abnormal_myocardial_fiber	1.11483096
60	MP0001929_abnormal_gametogenesis	1.09994902
61	MP0003693_abnormal_embryo_hatching	1.09557920
62	MP0005379_endocrine/exocrine_gland_phen	1.04939191
63	MP0000383_abnormal_hair_follicle	1.04737344
64	MP0005171_absent_coat_pigmentation	1.02769879
65	MP0000049_abnormal_middle_ear	1.00597249
66	MP0004043_abnormal_pH_regulation	0.99978321
67	MP0005195_abnormal_posterior_eye	0.99590232
68	MP0003787_abnormal_imprinting	0.98529221
69	MP0001145_abnormal_male_reproductive	0.98444583
70	MP0004145_abnormal_muscle_electrophysio	0.97456511
71	MP0000653_abnormal_sex_gland	0.97118074
72	MP0000026_abnormal_inner_ear	0.96933627
73	MP0003698_abnormal_male_reproductive	0.96848228
74	MP0002064_seizures	0.96098045
75	MP0005367_renal/urinary_system_phenotyp	0.94728054
76	MP0000516_abnormal_urinary_system	0.94728054
77	MP0002095_abnormal_skin_pigmentation	0.94712563
78	MP0003937_abnormal_limbs/digits/tail_de	0.94406288
79	MP0002067_abnormal_sensory_capabilities	0.92065046
80	MP0008775_abnormal_heart_ventricle	0.90912643
81	MP0001970_abnormal_pain_threshold	0.89679637
82	MP0003283_abnormal_digestive_organ	0.89203602
83	MP0002733_abnormal_thermal_nociception	0.89049798
84	MP0005386_behavior/neurological_phenoty	0.88026266
85	MP0004924_abnormal_behavior	0.88026266
86	MP0000647_abnormal_sebaceous_gland	0.87693678
87	MP0002184_abnormal_innervation	0.87334981
88	MP0005085_abnormal_gallbladder_physiolo	0.87294367
89	MP0000538_abnormal_urinary_bladder	0.86578585
90	MP0002572_abnormal_emotion/affect_behav	0.86205364
91	MP0006276_abnormal_autonomic_nervous	0.85500005
92	MP0008057_abnormal_DNA_replication	0.84924380
93	MP0002752_abnormal_somatic_nervous	0.84703749
94	MP0002557_abnormal_social/conspecific_i	0.83518508
95	MP0001963_abnormal_hearing_physiology	0.83218428
96	MP0002234_abnormal_pharynx_morphology	0.82084246
97	MP0008789_abnormal_olfactory_epithelium	0.82017403
98	MP0002734_abnormal_mechanical_nocicepti	0.81864329
99	MP0008995_early_reproductive_senescence	0.81602387
100	MP0001873_stomach_inflammation	0.80174841

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.36564013
2	Abnormality of midbrain morphology (HP:0002418)	4.02483011
3	Molar tooth sign on MRI (HP:0002419)	4.02483011
4	Pancreatic fibrosis (HP:0100732)	4.01904885
5	True hermaphroditism (HP:0010459)	3.94902378
6	Congenital stationary night blindness (HP:0007642)	3.51290818
7	Type II lissencephaly (HP:0007260)	3.32986919
8	Nephronophthisis (HP:0000090)	3.31374683
9	Attenuation of retinal blood vessels (HP:0007843)	2.91321794
10	Pendular nystagmus (HP:0012043)	2.90913113
11	Medial flaring of the eyebrow (HP:0010747)	2.87092797
12	Abnormality of the renal cortex (HP:0011035)	2.85311990
13	Chronic hepatic failure (HP:0100626)	2.84457015
14	Abnormality of the renal medulla (HP:0100957)	2.80872003
15	Abolished electroretinogram (ERG) (HP:0000550)	2.77005508
16	Cystic liver disease (HP:0006706)	2.61170897
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.48423657
18	Sclerocornea (HP:0000647)	2.48383560
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.47130753
20	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.47001159
21	Tubular atrophy (HP:0000092)	2.45892019
22	Abnormality of the ileum (HP:0001549)	2.44047673
23	Patellar aplasia (HP:0006443)	2.43164309
24	Stomach cancer (HP:0012126)	2.39465039
25	Meckel diverticulum (HP:0002245)	2.38927508
26	Congenital, generalized hypertrichosis (HP:0004540)	2.37327233
27	Aplasia/Hypoplasia of the patella (HP:0006498)	2.37155128
28	Increased corneal curvature (HP:0100692)	2.34412845
29	Keratoconus (HP:0000563)	2.34412845
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.33554781
31	Concave nail (HP:0001598)	2.32574541
32	Abnormality of the labia minora (HP:0012880)	2.31707475
33	Gaze-evoked nystagmus (HP:0000640)	2.25924194
34	Volvulus (HP:0002580)	2.25772702
35	Hypoplasia of the pons (HP:0012110)	2.24022583
36	Abnormality of the pons (HP:0007361)	2.23497756
37	Anencephaly (HP:0002323)	2.22123683
38	Decreased central vision (HP:0007663)	2.19335787
39	Oligodactyly (hands) (HP:0001180)	2.17659694
40	Retinal dysplasia (HP:0007973)	2.17161957
41	Male pseudohermaphroditism (HP:0000037)	2.16558045
42	Congenital primary aphakia (HP:0007707)	2.15939545
43	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.14378513
44	Renal cortical cysts (HP:0000803)	2.13475862
45	Optic nerve hypoplasia (HP:0000609)	2.12766019
46	Gait imbalance (HP:0002141)	2.12705739
47	Abnormal drinking behavior (HP:0030082)	2.12550631
48	Polydipsia (HP:0001959)	2.12550631
49	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.12463154
50	Hypothermia (HP:0002045)	2.12265690
51	Cerebellar dysplasia (HP:0007033)	2.11904535
52	Congenital hepatic fibrosis (HP:0002612)	2.10961440
53	Postaxial foot polydactyly (HP:0001830)	2.07717129
54	Hyperventilation (HP:0002883)	2.07686046
55	Genital tract atresia (HP:0001827)	2.07587131
56	Small hand (HP:0200055)	2.05784467
57	Acute necrotizing encephalopathy (HP:0006965)	2.04781298
58	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.03825945
59	Furrowed tongue (HP:0000221)	2.03779157
60	Abnormality of chromosome stability (HP:0003220)	2.00914462
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.00328888
62	Chromsome breakage (HP:0040012)	1.99692530
63	Large for gestational age (HP:0001520)	1.97281007
64	Lissencephaly (HP:0001339)	1.97098484
65	Increased CSF lactate (HP:0002490)	1.97029076
66	Vaginal atresia (HP:0000148)	1.95239158
67	Nephrogenic diabetes insipidus (HP:0009806)	1.95003524
68	Progressive inability to walk (HP:0002505)	1.94402216
69	Absent thumb (HP:0009777)	1.93778696
70	Abnormality of B cell number (HP:0010975)	1.93343449
71	Short tibia (HP:0005736)	1.93076374
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.92971216
73	Postaxial hand polydactyly (HP:0001162)	1.92885656
74	Ectopic kidney (HP:0000086)	1.91236561
75	Abnormality of alanine metabolism (HP:0010916)	1.91017708
76	Hyperalaninemia (HP:0003348)	1.91017708
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.91017708
78	Mitochondrial inheritance (HP:0001427)	1.90678334
79	Clubbing of toes (HP:0100760)	1.90320978
80	Aplasia/hypoplasia of the uterus (HP:0008684)	1.88034763
81	Progressive macrocephaly (HP:0004481)	1.86542280
82	Birth length less than 3rd percentile (HP:0003561)	1.86261241
83	Sloping forehead (HP:0000340)	1.85948292
84	Septo-optic dysplasia (HP:0100842)	1.84998333
85	Abnormality of the preputium (HP:0100587)	1.84532824
86	Inability to walk (HP:0002540)	1.82248412
87	Astigmatism (HP:0000483)	1.80738995
88	3-Methylglutaconic aciduria (HP:0003535)	1.80164832
89	Lipid accumulation in hepatocytes (HP:0006561)	1.79843873
90	Preaxial hand polydactyly (HP:0001177)	1.79334876
91	Intestinal atresia (HP:0011100)	1.78935589
92	Progressive cerebellar ataxia (HP:0002073)	1.77889095
93	Bony spicule pigmentary retinopathy (HP:0007737)	1.77622055
94	Acute encephalopathy (HP:0006846)	1.74184896
95	Bile duct proliferation (HP:0001408)	1.73269840
96	Abnormal biliary tract physiology (HP:0012439)	1.73269840
97	Asplenia (HP:0001746)	1.72017663
98	Congenital sensorineural hearing impairment (HP:0008527)	1.71459643
99	Polyuria (HP:0000103)	1.71231922
100	Chorioretinal atrophy (HP:0000533)	1.69329406

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.15798080
2	BMPR1B	4.10385526
3	ACVR1B	3.16891225
4	ADRBK2	3.00249275
5	WNK3	2.77597087
6	PNCK	2.60153152
7	ZAK	2.55166483
8	TLK1	2.37132112
9	GRK1	2.11124892
10	MAP4K2	2.09694255
11	NUAK1	1.98809549
12	CASK	1.98052006
13	MKNK2	1.96920474
14	TSSK6	1.84790668
15	PINK1	1.84483535
16	TGFBR1	1.82367542
17	WNK4	1.79590221
18	STK39	1.59762717
19	INSRR	1.56240615
20	VRK1	1.44090089
21	WEE1	1.42028314
22	OXSR1	1.40769866
23	PLK4	1.36545287
24	MAPK15	1.36167326
25	MAPK13	1.35049841
26	FGFR2	1.34893014
27	TNIK	1.25688100
28	MAP3K4	1.16038177
29	TAOK3	1.12646261
30	CDK8	1.12557008
31	BRSK2	1.06906534
32	EIF2AK3	1.05154939
33	MKNK1	1.03796976
34	PLK3	1.03220852
35	PRKCE	1.00838133
36	BUB1	1.00022513
37	ADRBK1	0.97215411
38	DAPK2	0.96223219
39	TXK	0.93222039
40	BCKDK	0.92627479
41	CAMKK2	0.87869354
42	CDC7	0.87098110
43	TIE1	0.85424473
44	DYRK2	0.84763460
45	TAF1	0.84339965
46	MST4	0.84013283
47	PRKCG	0.83504695
48	PLK2	0.81639197
49	PAK3	0.79433943
50	MAP2K6	0.75686516
51	CSNK1G1	0.74922007
52	TRIM28	0.73343107
53	CCNB1	0.72890143
54	PKN1	0.72048576
55	RPS6KA5	0.70576888
56	CSNK1G2	0.70494274
57	PIK3CA	0.69273084
58	EPHA4	0.66439397
59	IRAK1	0.66373967
60	ATR	0.65647483
61	TEC	0.64967811
62	PLK1	0.64289888
63	CHEK2	0.62880829
64	STK38L	0.61812829
65	MUSK	0.61595245
66	VRK2	0.58455344
67	CSNK1G3	0.55145979
68	NTRK2	0.54585417
69	PASK	0.52477896
70	NME1	0.52476573
71	MAPKAPK5	0.52402953
72	NTRK3	0.50795653
73	STK3	0.47138454
74	ATM	0.46872468
75	MAP2K7	0.46742418
76	CSNK1A1	0.46609401
77	IKBKB	0.45883765
78	PRKCI	0.45823360
79	PTK2B	0.45088211
80	CAMK2A	0.44970268
81	TTK	0.43538399
82	ERBB3	0.43508680
83	CDK3	0.42331776
84	PRKCQ	0.41328518
85	PRKACA	0.41137408
86	CAMK1	0.40675871
87	SRPK1	0.39232680
88	RPS6KA4	0.39135124
89	NLK	0.38697537
90	CSNK1A1L	0.38563068
91	STK11	0.38265603
92	MARK1	0.37341392
93	MAPKAPK3	0.36648291
94	PHKG2	0.35924402
95	PHKG1	0.35924402
96	CSNK1D	0.33869388
97	AURKB	0.33699339
98	ERBB2	0.32231957
99	CSNK2A1	0.31214480
100	NEK1	0.30944619

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	2.85497434
2	Phototransduction_Homo sapiens_hsa04744	2.84217338
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.57384061
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.42793855
5	Basal transcription factors_Homo sapiens_hsa03022	2.30075180
6	One carbon pool by folate_Homo sapiens_hsa00670	2.18809392
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.14606310
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14121516
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.12670296
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.11800437
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.11219380
12	Protein export_Homo sapiens_hsa03060	2.11058861
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10572720
14	RNA polymerase_Homo sapiens_hsa03020	2.05176906
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.92548664
16	Caffeine metabolism_Homo sapiens_hsa00232	1.88851057
17	Butanoate metabolism_Homo sapiens_hsa00650	1.88477248
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87981840
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.86190990
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85489553
21	Nicotine addiction_Homo sapiens_hsa05033	1.85385838
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73618924
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.68741545
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.60719913
25	RNA degradation_Homo sapiens_hsa03018	1.55994986
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52958470
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.50927792
28	Parkinsons disease_Homo sapiens_hsa05012	1.49472427
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.45846838
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.35355720
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.27831933
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.26494612
33	Taste transduction_Homo sapiens_hsa04742	1.21549390
34	Huntingtons disease_Homo sapiens_hsa05016	1.14074468
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13663560
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08833050
37	Propanoate metabolism_Homo sapiens_hsa00640	1.08134387
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.07939432
39	Mismatch repair_Homo sapiens_hsa03430	1.07226655
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06285301
41	Regulation of autophagy_Homo sapiens_hsa04140	1.02272159
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01825608
43	Olfactory transduction_Homo sapiens_hsa04740	0.99882220
44	Retinol metabolism_Homo sapiens_hsa00830	0.98826394
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.88098165
46	Morphine addiction_Homo sapiens_hsa05032	0.87036024
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.85897681
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84058894
49	DNA replication_Homo sapiens_hsa03030	0.83050146
50	Alzheimers disease_Homo sapiens_hsa05010	0.82682460
51	Proteasome_Homo sapiens_hsa03050	0.82556278
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.81618400
53	RNA transport_Homo sapiens_hsa03013	0.80667610
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80364624
55	ABC transporters_Homo sapiens_hsa02010	0.79736312
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79509662
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79205004
58	Peroxisome_Homo sapiens_hsa04146	0.79020632
59	Purine metabolism_Homo sapiens_hsa00230	0.78671992
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78582771
61	Insulin secretion_Homo sapiens_hsa04911	0.75380010
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75289725
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74100073
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73388615
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73187321
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70795595
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68968278
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67187912
69	GABAergic synapse_Homo sapiens_hsa04727	0.66299618
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65886043
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62539913
72	Serotonergic synapse_Homo sapiens_hsa04726	0.62469196
73	Folate biosynthesis_Homo sapiens_hsa00790	0.60252632
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.59193582
75	Ribosome_Homo sapiens_hsa03010	0.58293348
76	Circadian entrainment_Homo sapiens_hsa04713	0.57319885
77	Metabolic pathways_Homo sapiens_hsa01100	0.57078277
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56672954
79	Histidine metabolism_Homo sapiens_hsa00340	0.55919415
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.55810613
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.54921054
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54756952
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.54491966
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.52325410
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52322911
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51761052
87	Base excision repair_Homo sapiens_hsa03410	0.51596688
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51577302
89	Sulfur metabolism_Homo sapiens_hsa00920	0.50927924
90	Spliceosome_Homo sapiens_hsa03040	0.49320531
91	p53 signaling pathway_Homo sapiens_hsa04115	0.49068616
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47816283
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46430690
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45631950
95	Mineral absorption_Homo sapiens_hsa04978	0.44163533
96	Salivary secretion_Homo sapiens_hsa04970	0.40938332
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39011137
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.37997502
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.36819569
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36272604

ZNF492

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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