ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	branching involved in labyrinthine layer morphogenesis (GO:0060670)	6.67347238
2	behavioral response to nicotine (GO:0035095)	4.87472178
3	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	4.74895174
4	positive regulation of oligodendrocyte differentiation (GO:0048714)	4.34218496
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.25277866
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.25277866
7	NADH dehydrogenase complex assembly (GO:0010257)	4.25277866
8	presynaptic membrane assembly (GO:0097105)	4.21258789
9	DNA deamination (GO:0045006)	4.09213828
10	spindle assembly involved in mitosis (GO:0090307)	4.05030395
11	prostate gland growth (GO:0060736)	4.03076051
12	response to lipoprotein particle (GO:0055094)	4.01846310
13	negative regulation of telomerase activity (GO:0051974)	3.91689358
14	mitochondrion morphogenesis (GO:0070584)	3.87480894
15	somite development (GO:0061053)	3.78951115
16	presynaptic membrane organization (GO:0097090)	3.68348772
17	positive regulation of mitochondrial fission (GO:0090141)	3.66804523
18	negative regulation of Rho protein signal transduction (GO:0035024)	3.64386940
19	sulfation (GO:0051923)	3.61014207
20	response to pheromone (GO:0019236)	3.57234475
21	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.51148777
22	cell proliferation in forebrain (GO:0021846)	3.40337438
23	regulation of inositol phosphate biosynthetic process (GO:0010919)	3.40057309
24	regulation of collateral sprouting (GO:0048670)	3.38298436
25	anterior/posterior axis specification, embryo (GO:0008595)	3.37909349
26	synapsis (GO:0007129)	3.36757446
27	protein complex biogenesis (GO:0070271)	3.36406648
28	peristalsis (GO:0030432)	3.32260758
29	positive regulation of fatty acid oxidation (GO:0046321)	3.31884982
30	serine family amino acid catabolic process (GO:0009071)	3.28197431
31	spinal cord development (GO:0021510)	3.27865018
32	indolalkylamine metabolic process (GO:0006586)	3.25860182
33	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.25155460
34	lung-associated mesenchyme development (GO:0060484)	3.19376456
35	regulation of translation, ncRNA-mediated (GO:0045974)	3.18691047
36	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.18691047
37	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.18691047
38	response to caffeine (GO:0031000)	3.18262129
39	negative regulation of mast cell activation (GO:0033004)	3.17083442
40	indole-containing compound catabolic process (GO:0042436)	3.15823334
41	indolalkylamine catabolic process (GO:0046218)	3.15823334
42	tryptophan catabolic process (GO:0006569)	3.15823334
43	centrosome duplication (GO:0051298)	3.13667301
44	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	3.13293709
45	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12860817
46	regulation of sequestering of triglyceride (GO:0010889)	3.12557371
47	hindbrain development (GO:0030902)	3.10865209
48	cilium or flagellum-dependent cell motility (GO:0001539)	3.07269252
49	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.98667882
50	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.98667882
51	peripheral nervous system axon ensheathment (GO:0032292)	2.92542881
52	myelination in peripheral nervous system (GO:0022011)	2.92542881
53	fucose catabolic process (GO:0019317)	2.92406242
54	L-fucose metabolic process (GO:0042354)	2.92406242
55	L-fucose catabolic process (GO:0042355)	2.92406242
56	regulation of energy homeostasis (GO:2000505)	2.91077174
57	neuronal action potential (GO:0019228)	2.90820573
58	gamma-aminobutyric acid transport (GO:0015812)	2.90017766
59	inner cell mass cell proliferation (GO:0001833)	2.87999891
60	protein polyglutamylation (GO:0018095)	2.86342061
61	interkinetic nuclear migration (GO:0022027)	2.86264830
62	regulation of mitochondrial fission (GO:0090140)	2.84513253
63	flavonoid metabolic process (GO:0009812)	2.82302351
64	kynurenine metabolic process (GO:0070189)	2.80736929
65	regulation of cell proliferation involved in kidney development (GO:1901722)	2.80071334
66	negative regulation of systemic arterial blood pressure (GO:0003085)	2.79791505
67	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.74937032
68	regulation of telomerase activity (GO:0051972)	2.74052427
69	indole-containing compound metabolic process (GO:0042430)	2.73628123
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.72324011
71	detection of light stimulus involved in visual perception (GO:0050908)	2.72324011
72	regulation of posttranscriptional gene silencing (GO:0060147)	2.68857911
73	regulation of gene silencing by miRNA (GO:0060964)	2.68857911
74	regulation of gene silencing by RNA (GO:0060966)	2.68857911
75	regulation of hippo signaling (GO:0035330)	2.68780932
76	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.67573715
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.67048770
78	cellular response to ATP (GO:0071318)	2.66201556
79	postsynaptic membrane organization (GO:0001941)	2.65564872
80	serotonin metabolic process (GO:0042428)	2.65230345
81	negative regulation of astrocyte differentiation (GO:0048712)	2.65086439
82	regulation of action potential (GO:0098900)	2.65073015
83	neural tube formation (GO:0001841)	2.62311977
84	primary amino compound metabolic process (GO:1901160)	2.62201242
85	tryptophan metabolic process (GO:0006568)	2.61739162
86	white fat cell differentiation (GO:0050872)	2.61690082
87	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.60200429
88	organ growth (GO:0035265)	2.59116170
89	limb development (GO:0060173)	2.56714675
90	appendage development (GO:0048736)	2.56714675
91	dentate gyrus development (GO:0021542)	2.53864431
92	monoubiquitinated protein deubiquitination (GO:0035520)	2.53228007
93	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.49151370
94	lateral sprouting from an epithelium (GO:0060601)	2.46830010
95	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.45938031
96	kidney morphogenesis (GO:0060993)	2.44064880
97	action potential (GO:0001508)	2.43524776
98	phasic smooth muscle contraction (GO:0014821)	2.43434420
99	negative regulation of DNA biosynthetic process (GO:2000279)	2.41901623
100	ventricular septum development (GO:0003281)	2.40620963

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.17007731
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.45052749
3	* ZNF274_21170338_ChIP-Seq_K562_Hela	2.98925031
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80446545
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56892395
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55839630
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.53384128
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50135074
9	FUS_26573619_Chip-Seq_HEK293_Human	2.42666065
10	VDR_22108803_ChIP-Seq_LS180_Human	2.40415507
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30141749
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.21363477
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.20354961
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.17756979
15	EWS_26573619_Chip-Seq_HEK293_Human	2.06842509
16	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06744060
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.05596380
18	P300_19829295_ChIP-Seq_ESCs_Human	2.02132037
19	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.95113965
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.90159096
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.89561517
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.89237259
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.82172315
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.81871374
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77308576
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.65297560
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.63815998
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63162165
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62638905
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61766989
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60559443
32	STAT3_23295773_ChIP-Seq_U87_Human	1.59906548
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.59594774
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56562421
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56441359
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.54991873
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51708315
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50613528
39	TCF4_23295773_ChIP-Seq_U87_Human	1.47655915
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45691651
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.45634154
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.44194540
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41489045
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40209278
45	AR_25329375_ChIP-Seq_VCAP_Human	1.39028505
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38737785
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37881477
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37788768
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37788768
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33410241
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31533202
52	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.29075484
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27639225
54	* MYC_18940864_ChIP-ChIP_HL60_Human	1.27413568
55	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.27342227
56	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26789789
57	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25559525
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25285780
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.24507034
60	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.24372322
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24096677
62	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23356698
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.22612063
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22612063
65	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.21366340
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21012850
67	AR_21572438_ChIP-Seq_LNCaP_Human	1.20891111
68	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20696202
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20463959
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19003306
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17371972
72	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16473539
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16427558
74	AHR_22903824_ChIP-Seq_MCF-7_Human	1.15783039
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14740782
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14443983
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12656851
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12612107
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11551257
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10236873
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09897602
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09897602
83	DROSHA_22980978_ChIP-Seq_HELA_Human	1.08938594
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08027688
85	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07218922
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.05464616
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04976479
88	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.04627091
89	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04237390
90	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.04140948
91	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03052985
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03004231
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02055947
94	TP53_22573176_ChIP-Seq_HFKS_Human	1.01905179
95	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01449024
96	NCOR_22424771_ChIP-Seq_293T_Human	1.00662862
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00356936
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99528646
99	RXR_22108803_ChIP-Seq_LS180_Human	0.98333320
100	JUN_21703547_ChIP-Seq_K562_Human	0.98270775

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	3.40256657
2	MP0002653_abnormal_ependyma_morphology	3.13639079
3	MP0001485_abnormal_pinna_reflex	3.10649841
4	MP0000569_abnormal_digit_pigmentation	2.97428928
5	MP0008877_abnormal_DNA_methylation	2.60660997
6	MP0000516_abnormal_urinary_system	2.43714004
7	MP0005367_renal/urinary_system_phenotyp	2.43714004
8	MP0003315_abnormal_perineum_morphology	2.37372219
9	MP0006292_abnormal_olfactory_placode	2.32954333
10	MP0005646_abnormal_pituitary_gland	2.29377936
11	MP0000049_abnormal_middle_ear	2.10382394
12	MP0009046_muscle_twitch	2.06502153
13	MP0002102_abnormal_ear_morphology	2.01696134
14	MP0003890_abnormal_embryonic-extraembry	2.00837241
15	MP0003119_abnormal_digestive_system	1.95288618
16	MP0002160_abnormal_reproductive_system	1.92925228
17	MP0003787_abnormal_imprinting	1.85983553
18	MP0000631_abnormal_neuroendocrine_gland	1.81498387
19	MP0002735_abnormal_chemical_nociception	1.78107116
20	MP0001968_abnormal_touch/_nociception	1.75046436
21	MP0000013_abnormal_adipose_tissue	1.73740413
22	MP0009745_abnormal_behavioral_response	1.69427031
23	MP0008872_abnormal_physiological_respon	1.69002528
24	MP0004130_abnormal_muscle_cell	1.67512058
25	MP0002837_dystrophic_cardiac_calcinosis	1.65675122
26	MP0005551_abnormal_eye_electrophysiolog	1.65280172
27	MP0003195_calcinosis	1.63091208
28	MP0002272_abnormal_nervous_system	1.59445553
29	MP0005174_abnormal_tail_pigmentation	1.57308885
30	MP0002138_abnormal_hepatobiliary_system	1.56907121
31	MP0006072_abnormal_retinal_apoptosis	1.54447460
32	MP0004885_abnormal_endolymph	1.53899296
33	MP0000778_abnormal_nervous_system	1.51958827
34	MP0004133_heterotaxia	1.51784784
35	MP0003635_abnormal_synaptic_transmissio	1.48753603
36	MP0003880_abnormal_central_pattern	1.47155578
37	MP0002751_abnormal_autonomic_nervous	1.44857267
38	MP0003937_abnormal_limbs/digits/tail_de	1.43304981
39	MP0003693_abnormal_embryo_hatching	1.42806815
40	MP0005389_reproductive_system_phenotype	1.41781582
41	MP0003724_increased_susceptibility_to	1.41732574
42	MP0003646_muscle_fatigue	1.41300691
43	MP0002572_abnormal_emotion/affect_behav	1.40449813
44	MP0002876_abnormal_thyroid_physiology	1.37673934
45	MP0006276_abnormal_autonomic_nervous	1.36644969
46	MP0004142_abnormal_muscle_tone	1.34210811
47	MP0003718_maternal_effect	1.33291284
48	MP0005253_abnormal_eye_physiology	1.31945975
49	MP0003136_yellow_coat_color	1.30524630
50	MP0002064_seizures	1.29197440
51	MP0009053_abnormal_anal_canal	1.23955405
52	MP0000383_abnormal_hair_follicle	1.23228709
53	MP0001486_abnormal_startle_reflex	1.21290591
54	MP0001986_abnormal_taste_sensitivity	1.21089159
55	MP0002638_abnormal_pupillary_reflex	1.19635289
56	MP0004145_abnormal_muscle_electrophysio	1.19296769
57	MP0002063_abnormal_learning/memory/cond	1.19129316
58	MP0005645_abnormal_hypothalamus_physiol	1.17250059
59	MP0005195_abnormal_posterior_eye	1.16967662
60	MP0001440_abnormal_grooming_behavior	1.12069263
61	MP0002928_abnormal_bile_duct	1.11749584
62	MP0003121_genomic_imprinting	1.11220351
63	MP0002557_abnormal_social/conspecific_i	1.08055633
64	MP0003283_abnormal_digestive_organ	1.07290356
65	MP0001963_abnormal_hearing_physiology	1.05236985
66	MP0000427_abnormal_hair_cycle	1.05179677
67	MP0002067_abnormal_sensory_capabilities	1.04932145
68	MP0003567_abnormal_fetal_cardiomyocyte	1.03634005
69	MP0002938_white_spotting	1.02308081
70	MP0002733_abnormal_thermal_nociception	0.97033078
71	MP0001661_extended_life_span	0.96079202
72	MP0001970_abnormal_pain_threshold	0.95818609
73	MP0002282_abnormal_trachea_morphology	0.94839163
74	MP0002736_abnormal_nociception_after	0.94728673
75	MP0002095_abnormal_skin_pigmentation	0.93669622
76	MP0004742_abnormal_vestibular_system	0.91888560
77	MP0003938_abnormal_ear_development	0.90847238
78	MP0004924_abnormal_behavior	0.89877808
79	MP0005386_behavior/neurological_phenoty	0.89877808
80	MP0002752_abnormal_somatic_nervous	0.88759429
81	MP0002734_abnormal_mechanical_nocicepti	0.88001641
82	MP0002882_abnormal_neuron_morphology	0.86544252
83	MP0000955_abnormal_spinal_cord	0.85084059
84	MP0000015_abnormal_ear_pigmentation	0.85008580
85	MP0001501_abnormal_sleep_pattern	0.84615718
86	MP0005084_abnormal_gallbladder_morpholo	0.84563930
87	MP0004043_abnormal_pH_regulation	0.83382094
88	MP0003936_abnormal_reproductive_system	0.82649239
89	MP0001188_hyperpigmentation	0.82461411
90	MP0009765_abnormal_xenobiotic_induced	0.82445712
91	MP0002152_abnormal_brain_morphology	0.81648746
92	MP0003011_delayed_dark_adaptation	0.77148944
93	MP0001293_anophthalmia	0.76910759
94	MP0000230_abnormal_systemic_arterial	0.75727885
95	MP0002184_abnormal_innervation	0.75427818
96	MP0003122_maternal_imprinting	0.75377659
97	MP0001919_abnormal_reproductive_system	0.75156433
98	MP0009384_cardiac_valve_regurgitation	0.73716356
99	MP0004185_abnormal_adipocyte_glucose	0.73247606
100	MP0008995_early_reproductive_senescence	0.73099961

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Short 1st metacarpal (HP:0010034)	4.98371798
2	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	4.98371798
3	Stenosis of the external auditory canal (HP:0000402)	4.56749057
4	Abnormality of the 1st metacarpal (HP:0010009)	4.36797667
5	Ectopic kidney (HP:0000086)	4.16642062
6	Carpal bone hypoplasia (HP:0001498)	3.54835119
7	Pancreatic cysts (HP:0001737)	3.53326427
8	Abnormality of the renal collecting system (HP:0004742)	3.42080446
9	Short hallux (HP:0010109)	3.35031010
10	Pancreatic fibrosis (HP:0100732)	3.33435092
11	Short phalanx of the thumb (HP:0009660)	3.32457558
12	True hermaphroditism (HP:0010459)	3.25281072
13	Absent thumb (HP:0009777)	3.22624803
14	Duplicated collecting system (HP:0000081)	3.20717825
15	Rectal fistula (HP:0100590)	3.16504061
16	Rectovaginal fistula (HP:0000143)	3.16504061
17	Aplasia/Hypoplasia of the hallux (HP:0008362)	3.15062133
18	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.05917487
19	Abnormality of midbrain morphology (HP:0002418)	3.05008338
20	Molar tooth sign on MRI (HP:0002419)	3.05008338
21	Genetic anticipation (HP:0003743)	2.99325395
22	Fused cervical vertebrae (HP:0002949)	2.98220525
23	Congenital stationary night blindness (HP:0007642)	2.93267495
24	Nephronophthisis (HP:0000090)	2.91091139
25	Progressive cerebellar ataxia (HP:0002073)	2.86404002
26	Pendular nystagmus (HP:0012043)	2.80775121
27	Intestinal fistula (HP:0100819)	2.76614758
28	Abolished electroretinogram (ERG) (HP:0000550)	2.73360980
29	Abnormality of DNA repair (HP:0003254)	2.72728495
30	Chromsome breakage (HP:0040012)	2.71956605
31	Absent radius (HP:0003974)	2.69397188
32	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.66727793
33	Absent forearm bone (HP:0003953)	2.63031527
34	Aplasia involving forearm bones (HP:0009822)	2.63031527
35	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.62380997
36	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.58621273
37	Vaginal fistula (HP:0004320)	2.47817532
38	Hyperventilation (HP:0002883)	2.42201812
39	Abnormality of the renal medulla (HP:0100957)	2.40946695
40	Tachypnea (HP:0002789)	2.40378999
41	Optic nerve coloboma (HP:0000588)	2.38479464
42	Abnormality of the parathyroid morphology (HP:0011766)	2.36499122
43	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.32384715
44	Horseshoe kidney (HP:0000085)	2.27597902
45	Cystic liver disease (HP:0006706)	2.27429182
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.27135471
47	Congenital sensorineural hearing impairment (HP:0008527)	2.25865421
48	Osteomalacia (HP:0002749)	2.25542851
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.19976452
50	Absent/shortened dynein arms (HP:0200106)	2.19976452
51	Gaze-evoked nystagmus (HP:0000640)	2.19810572
52	Broad-based gait (HP:0002136)	2.18694052
53	Abnormality of the carotid arteries (HP:0005344)	2.18661383
54	Short thumb (HP:0009778)	2.16793631
55	Synostosis of carpal bones (HP:0005048)	2.15111607
56	Chronic hepatic failure (HP:0100626)	2.14291872
57	Preaxial foot polydactyly (HP:0001841)	2.12981263
58	Abnormal respiratory epithelium morphology (HP:0012253)	2.12789903
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12789903
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.12764273
61	Febrile seizures (HP:0002373)	2.12540296
62	Chorioretinal atrophy (HP:0000533)	2.10711224
63	Oligomenorrhea (HP:0000876)	2.09918299
64	Reticulocytopenia (HP:0001896)	2.07581763
65	Keratoconus (HP:0000563)	2.05725114
66	Increased corneal curvature (HP:0100692)	2.05725114
67	Abnormality of the nasal septum (HP:0000419)	2.04346489
68	Protruding tongue (HP:0010808)	2.03303400
69	Abnormality of alanine metabolism (HP:0010916)	2.02193410
70	Hyperalaninemia (HP:0003348)	2.02193410
71	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02193410
72	Meckel diverticulum (HP:0002245)	2.01378771
73	Triphalangeal thumb (HP:0001199)	2.01209268
74	Abnormality of the ileum (HP:0001549)	1.96483465
75	Inability to walk (HP:0002540)	1.96348659
76	Clumsiness (HP:0002312)	1.95904542
77	Status epilepticus (HP:0002133)	1.92001896
78	Short humerus (HP:0005792)	1.91089879
79	Medial flaring of the eyebrow (HP:0010747)	1.90211178
80	Sclerocornea (HP:0000647)	1.88921716
81	Maternal diabetes (HP:0009800)	1.88285617
82	Severe muscular hypotonia (HP:0006829)	1.87420665
83	Abnormality of chromosome stability (HP:0003220)	1.86878419
84	Clubbing of toes (HP:0100760)	1.82143417
85	Aplasia/hypoplasia of the humerus (HP:0006507)	1.82051398
86	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.82013547
87	Furrowed tongue (HP:0000221)	1.81951715
88	Neoplasm of the oral cavity (HP:0100649)	1.81925599
89	Morphological abnormality of the middle ear (HP:0008609)	1.80700504
90	Attenuation of retinal blood vessels (HP:0007843)	1.80477231
91	Tented upper lip vermilion (HP:0010804)	1.80052227
92	Esotropia (HP:0000565)	1.79460517
93	Preaxial hand polydactyly (HP:0001177)	1.78637896
94	Aplasia/Hypoplasia of the patella (HP:0006498)	1.78461932
95	Acute necrotizing encephalopathy (HP:0006965)	1.77751663
96	Anencephaly (HP:0002323)	1.77645903
97	Abnormality of the renal cortex (HP:0011035)	1.77582821
98	Chronic otitis media (HP:0000389)	1.74850376
99	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.70897098
100	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.70279543

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.72126930
2	GRK1	3.98084667
3	ADRBK2	3.26879297
4	CASK	3.24530940
5	BMPR1B	3.07860780
6	ACVR1B	2.42616074
7	WNK3	2.30508810
8	MAP3K4	2.22133799
9	MAPK13	2.15684133
10	PINK1	2.14618852
11	TLK1	2.05318500
12	INSRR	2.02317109
13	ZAK	1.87437850
14	TAOK3	1.68509082
15	MAP2K7	1.68111245
16	NUAK1	1.67615783
17	CDC7	1.64990884
18	MKNK2	1.52429167
19	MARK1	1.48863091
20	MAP4K2	1.39656755
21	CDK9	1.38885305
22	NTRK3	1.37860612
23	DYRK2	1.28532919
24	TNIK	1.28414562
25	OXSR1	1.17839344
26	DYRK3	1.12108639
27	DAPK2	1.12031674
28	WNK4	1.11535032
29	MAP2K1	1.05825851
30	PLK2	1.00109181
31	SGK2	0.99375328
32	PAK3	0.96465198
33	ADRBK1	0.95619824
34	CDK19	0.95465661
35	PRKCG	0.95453609
36	PIK3CA	0.95442294
37	CSNK1G2	0.88893159
38	TRIM28	0.86909499
39	PRKCE	0.85649913
40	SGK494	0.85607360
41	SGK223	0.85607360
42	CSNK1G1	0.82824710
43	NTRK2	0.82437988
44	TAF1	0.82309477
45	STK39	0.78273397
46	CSNK1A1L	0.78043784
47	CAMKK2	0.77200735
48	PLK4	0.76041172
49	NLK	0.75248803
50	ATR	0.72443967
51	TEC	0.71748736
52	TGFBR1	0.69456861
53	CSNK1G3	0.68195546
54	DYRK1A	0.67697433
55	RPS6KA5	0.66929848
56	STK38L	0.65577870
57	PKN1	0.64921503
58	PNCK	0.62690522
59	OBSCN	0.62662677
60	FGFR2	0.62105537
61	CSNK1A1	0.61021939
62	EPHA4	0.60943590
63	VRK1	0.60786511
64	CAMK2A	0.60155406
65	CDK3	0.58617045
66	SIK2	0.58584020
67	CSNK1D	0.57081274
68	SYK	0.56187313
69	STK11	0.55719726
70	MAP2K4	0.55407898
71	BCR	0.54403002
72	CAMK1	0.53239567
73	MKNK1	0.52364872
74	PRKACA	0.51340465
75	BRSK2	0.50775790
76	CDK5	0.50345698
77	TIE1	0.48691676
78	SGK1	0.48552393
79	NEK2	0.48477403
80	MUSK	0.47656024
81	STK16	0.45616452
82	EPHA3	0.45330286
83	WNK1	0.44597458
84	PRKAA1	0.42175522
85	CAMK4	0.42006502
86	ATM	0.41865770
87	MAPK15	0.40546408
88	ERBB2	0.40130337
89	PLK1	0.39812244
90	FLT3	0.39154703
91	RPS6KA6	0.37664309
92	TXK	0.37104459
93	STK38	0.37060279
94	PRKAA2	0.36971709
95	MAP3K7	0.36577374
96	GSK3B	0.36542035
97	RPS6KB1	0.36294848
98	PHKG1	0.34029937
99	PHKG2	0.34029937
100	PRKCZ	0.33499952

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.16928049
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.94023032
3	Phototransduction_Homo sapiens_hsa04744	2.79216579
4	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.48159477
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23766465
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.22268875
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15465512
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.05451606
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.04746984
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.03600951
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.98457031
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.95174725
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.93372097
14	Homologous recombination_Homo sapiens_hsa03440	1.90925570
15	Taste transduction_Homo sapiens_hsa04742	1.86962795
16	Butanoate metabolism_Homo sapiens_hsa00650	1.84773312
17	Morphine addiction_Homo sapiens_hsa05032	1.78731546
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.63013855
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.61491850
20	Renin-angiotensin system_Homo sapiens_hsa04614	1.57366471
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.54354278
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49548589
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.48059590
24	RNA degradation_Homo sapiens_hsa03018	1.47128862
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.46229406
26	GABAergic synapse_Homo sapiens_hsa04727	1.45385395
27	RNA polymerase_Homo sapiens_hsa03020	1.44036724
28	Circadian entrainment_Homo sapiens_hsa04713	1.42545323
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42233545
30	Olfactory transduction_Homo sapiens_hsa04740	1.39984132
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.26983129
32	ABC transporters_Homo sapiens_hsa02010	1.26624616
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26165420
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.19740868
35	Serotonergic synapse_Homo sapiens_hsa04726	1.19666584
36	Insulin secretion_Homo sapiens_hsa04911	1.18441279
37	Basal transcription factors_Homo sapiens_hsa03022	1.16361997
38	Basal cell carcinoma_Homo sapiens_hsa05217	1.12060358
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09772184
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08955163
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.08048720
42	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03779082
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03414241
44	Retinol metabolism_Homo sapiens_hsa00830	1.01604894
45	Calcium signaling pathway_Homo sapiens_hsa04020	1.01044141
46	Caffeine metabolism_Homo sapiens_hsa00232	0.93960818
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91881025
48	Histidine metabolism_Homo sapiens_hsa00340	0.89841963
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.89374614
50	Axon guidance_Homo sapiens_hsa04360	0.89337193
51	Sulfur metabolism_Homo sapiens_hsa00920	0.87442994
52	Alzheimers disease_Homo sapiens_hsa05010	0.87209374
53	Regulation of autophagy_Homo sapiens_hsa04140	0.86905577
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86659195
55	Huntingtons disease_Homo sapiens_hsa05016	0.85446468
56	Cholinergic synapse_Homo sapiens_hsa04725	0.84491283
57	Salivary secretion_Homo sapiens_hsa04970	0.82840534
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82357658
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80057681
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.79716561
61	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.78126561
62	Cocaine addiction_Homo sapiens_hsa05030	0.77182714
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76947240
64	Parkinsons disease_Homo sapiens_hsa05012	0.76813276
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76232519
66	Long-term depression_Homo sapiens_hsa04730	0.74261767
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72634872
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.70204196
69	Alcoholism_Homo sapiens_hsa05034	0.67144500
70	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.66985062
71	Peroxisome_Homo sapiens_hsa04146	0.66872464
72	Primary immunodeficiency_Homo sapiens_hsa05340	0.66621283
73	Propanoate metabolism_Homo sapiens_hsa00640	0.66407798
74	Type II diabetes mellitus_Homo sapiens_hsa04930	0.66093817
75	Amphetamine addiction_Homo sapiens_hsa05031	0.64976559
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.64713830
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63418215
78	Renin secretion_Homo sapiens_hsa04924	0.63276979
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62360393
80	Gastric acid secretion_Homo sapiens_hsa04971	0.61113597
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59708126
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59346207
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59226607
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56946487
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.53487466
86	Asthma_Homo sapiens_hsa05310	0.53145752
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.52873767
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.51249542
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48687282
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.48445385
91	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.43247031
92	Protein export_Homo sapiens_hsa03060	0.43241645
93	Melanoma_Homo sapiens_hsa05218	0.43071101
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42705430
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.40888706
96	Lysine degradation_Homo sapiens_hsa00310	0.40183608
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.36771254
98	Circadian rhythm_Homo sapiens_hsa04710	0.33419142
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32948789
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.32298497

ZNF493

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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