ZNF496

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)4.86171654
2regulation of posttranscriptional gene silencing (GO:0060147)4.86171654
3regulation of gene silencing by miRNA (GO:0060964)4.86171654
4DNA unwinding involved in DNA replication (GO:0006268)4.69207098
5pre-miRNA processing (GO:0031054)4.66415594
6paraxial mesoderm development (GO:0048339)4.64093214
7heterochromatin organization (GO:0070828)4.55085283
8nuclear pore complex assembly (GO:0051292)4.45364862
9convergent extension (GO:0060026)4.22093140
10protein-DNA complex disassembly (GO:0032986)4.11761736
11nucleosome disassembly (GO:0006337)4.11761736
12nuclear pore organization (GO:0006999)4.00990419
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.88239275
14negative regulation of histone methylation (GO:0031061)3.87136501
15DNA topological change (GO:0006265)3.62607517
16establishment of apical/basal cell polarity (GO:0035089)3.56200120
17mitotic chromosome condensation (GO:0007076)3.44393753
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.43637398
19chromatin assembly (GO:0031497)3.40605090
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40302163
21DNA replication initiation (GO:0006270)3.35251886
22DNA duplex unwinding (GO:0032508)3.34456082
23pore complex assembly (GO:0046931)3.34201186
24histone H3-K9 methylation (GO:0051567)3.32765549
25neural tube development (GO:0021915)3.30625089
26regulation of translational fidelity (GO:0006450)3.24455940
27DNA geometric change (GO:0032392)3.22991533
28regulation of RNA export from nucleus (GO:0046831)3.17389302
29regulation of histone H3-K9 methylation (GO:0051570)3.16140120
30DNA strand elongation involved in DNA replication (GO:0006271)3.15435398
31establishment of monopolar cell polarity (GO:0061162)3.15329277
32establishment or maintenance of monopolar cell polarity (GO:0061339)3.15329277
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.14316595
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.14316595
35regulation of translation, ncRNA-mediated (GO:0045974)3.14316595
36regulation of stem cell maintenance (GO:2000036)3.05623673
37DNA strand elongation (GO:0022616)3.04321718
38mitotic sister chromatid cohesion (GO:0007064)2.97936475
39sister chromatid segregation (GO:0000819)2.97188505
40regulation of DNA damage checkpoint (GO:2000001)2.92333036
41mitotic sister chromatid segregation (GO:0000070)2.87238541
42negative regulation of gene expression, epigenetic (GO:0045814)2.84674826
43positive regulation of gene expression, epigenetic (GO:0045815)2.83602845
44RNA stabilization (GO:0043489)2.82189464
45mRNA stabilization (GO:0048255)2.82189464
46DNA damage induced protein phosphorylation (GO:0006975)2.81903024
47spliceosomal tri-snRNP complex assembly (GO:0000244)2.81523242
48chromatin silencing (GO:0006342)2.80829126
49DNA conformation change (GO:0071103)2.80509105
50negative regulation of DNA repair (GO:0045738)2.79032924
51glucocorticoid receptor signaling pathway (GO:0042921)2.78222423
52generation of neurons (GO:0048699)2.77313795
53peptidyl-lysine dimethylation (GO:0018027)2.76158368
54positive regulation of SMAD protein import into nucleus (GO:0060391)2.73486396
55negative regulation of mRNA processing (GO:0050686)2.72412725
56regulation of gene silencing (GO:0060968)2.71524268
57regulation of histone H3-K4 methylation (GO:0051569)2.70435545
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70392232
59histone H3-K9 modification (GO:0061647)2.68944456
60L-serine metabolic process (GO:0006563)2.68935268
61mitotic nuclear envelope disassembly (GO:0007077)2.68177078
62negative regulation of mRNA metabolic process (GO:1903312)2.67626184
63snRNA processing (GO:0016180)2.67524075
64snRNA metabolic process (GO:0016073)2.65326289
65notochord development (GO:0030903)2.62742267
66DNA alkylation (GO:0006305)2.62622426
67DNA methylation (GO:0006306)2.62622426
68protein localization to kinetochore (GO:0034501)2.59827051
69hematopoietic stem cell differentiation (GO:0060218)2.58790557
70mRNA transport (GO:0051028)2.57808990
71negative regulation of RNA splicing (GO:0033119)2.56789574
72peptidyl-arginine omega-N-methylation (GO:0035247)2.56359419
73negative regulation of histone modification (GO:0031057)2.55563523
74telomere maintenance via semi-conservative replication (GO:0032201)2.55115705
75stress granule assembly (GO:0034063)2.54610351
76meiotic chromosome segregation (GO:0045132)2.53496972
77positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.53330756
78positive regulation of cell cycle G2/M phase transition (GO:1902751)2.53330756
79regulation of nucleobase-containing compound transport (GO:0032239)2.52575745
80cell migration in hindbrain (GO:0021535)2.52262286
81nuclear envelope disassembly (GO:0051081)2.51454534
82membrane disassembly (GO:0030397)2.51454534
83positive regulation by host of viral transcription (GO:0043923)2.50410888
84somatic stem cell division (GO:0048103)2.49857379
85histone lysine methylation (GO:0034968)2.49673404
86regulation of establishment of planar polarity (GO:0090175)2.48367048
87histone methylation (GO:0016571)2.47134257
88regulation of histone methylation (GO:0031060)2.46682593
89chromosome condensation (GO:0030261)2.46467948
90histone arginine methylation (GO:0034969)2.46168780
91regulation of NFAT protein import into nucleus (GO:0051532)2.46027147
92viral mRNA export from host cell nucleus (GO:0046784)2.45839226
93histone H4-K8 acetylation (GO:0043982)2.44105398
94histone H4-K5 acetylation (GO:0043981)2.44105398
95outer ear morphogenesis (GO:0042473)2.42319673
963-UTR-mediated mRNA stabilization (GO:0070935)2.41229572
97negative regulation of chromatin modification (GO:1903309)2.39736714
98ATP-dependent chromatin remodeling (GO:0043044)2.39314808
99protein localization to chromosome, centromeric region (GO:0071459)2.39127995
100DNA replication checkpoint (GO:0000076)2.38798335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.70334592
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.79257838
3MYC_22102868_ChIP-Seq_BL_Human3.11359785
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.84392357
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.84018018
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62314011
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60853242
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.47173453
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.47173453
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.47173453
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.41858439
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22442212
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20533410
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15102965
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10281552
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08796194
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.04873803
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.92045583
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89070594
20CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85824960
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82181871
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80195002
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75826263
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75418733
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75167859
26VDR_21846776_ChIP-Seq_THP-1_Human1.74381485
27XRN2_22483619_ChIP-Seq_HELA_Human1.72669512
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72353114
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72156558
30ZFP281_27345836_Chip-Seq_ESCs_Mouse1.71902969
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61359180
32TCF7_22412390_ChIP-Seq_EML_Mouse1.60280968
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59825443
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58243889
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57478323
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56562004
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54833011
38KDM2B_26808549_Chip-Seq_DND41_Human1.53764721
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53263813
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52404725
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50657010
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46015945
43CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.46015744
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.45801267
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45747025
46NANOG_21062744_ChIP-ChIP_HESCs_Human1.45552152
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45053105
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44234049
49KDM5A_27292631_Chip-Seq_BREAST_Human1.42798735
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42546037
51* KDM2B_26808549_Chip-Seq_K562_Human1.42246174
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41235509
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41215008
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40147652
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.39141793
56ZNF263_19887448_ChIP-Seq_K562_Human1.38963087
57CIITA_25753668_ChIP-Seq_RAJI_Human1.38238227
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.36147806
59TTF2_22483619_ChIP-Seq_HELA_Human1.35556350
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33534093
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.32776768
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32502011
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29053324
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28828616
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26532119
66* NCOR1_26117541_ChIP-Seq_K562_Human1.25446475
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24961806
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23123465
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20882749
70* CREB1_26743006_Chip-Seq_LNCaP_Human1.18740496
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17254109
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15857801
73LXR_22292898_ChIP-Seq_THP-1_Human1.15729149
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14151391
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.12284617
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11240757
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10093195
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06401846
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05496452
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.05476945
81POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04320007
82* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03941300
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03084423
84RACK7_27058665_Chip-Seq_MCF-7_Human1.02606142
85P68_20966046_ChIP-Seq_HELA_Human1.00503282
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00312569
87NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99964840
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99065149
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98771229
90TP53_22127205_ChIP-Seq_IMR90_Human0.98604680
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93900730
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92820164
93* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91157194
94KAP1_27257070_Chip-Seq_ESCs_Mouse0.91059575
95WT1_19549856_ChIP-ChIP_CCG9911_Human0.89794734
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.88969241
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88231845
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88017410
99GABP_19822575_ChIP-Seq_HepG2_Human0.87784791
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84790954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology2.74180282
2MP0010094_abnormal_chromosome_stability2.60874544
3MP0003693_abnormal_embryo_hatching2.54768995
4MP0005076_abnormal_cell_differentiation2.38631540
5MP0008057_abnormal_DNA_replication2.29211832
6MP0006292_abnormal_olfactory_placode2.22124916
7MP0010030_abnormal_orbit_morphology2.21923946
8MP0002254_reproductive_system_inflammat2.17924589
9MP0004957_abnormal_blastocyst_morpholog2.09392055
10MP0009278_abnormal_bone_marrow2.06480450
11MP0003077_abnormal_cell_cycle2.04869872
12MP0009672_abnormal_birth_weight2.04859516
13MP0008932_abnormal_embryonic_tissue1.96269736
14MP0000537_abnormal_urethra_morphology1.93221741
15MP0003705_abnormal_hypodermis_morpholog1.90686320
16MP0002396_abnormal_hematopoietic_system1.86647341
17MP0001730_embryonic_growth_arrest1.85363218
18MP0003941_abnormal_skin_development1.83172000
19MP0003890_abnormal_embryonic-extraembry1.79854012
20MP0003385_abnormal_body_wall1.77091124
21MP0002085_abnormal_embryonic_tissue1.73753281
22MP0004197_abnormal_fetal_growth/weight/1.72663230
23MP0003937_abnormal_limbs/digits/tail_de1.71462358
24MP0002084_abnormal_developmental_patter1.71079829
25MP0000428_abnormal_craniofacial_morphol1.69365309
26MP0004233_abnormal_muscle_weight1.68367825
27MP0005380_embryogenesis_phenotype1.67796302
28MP0001672_abnormal_embryogenesis/_devel1.67796302
29MP0008058_abnormal_DNA_repair1.62035722
30MP0003942_abnormal_urinary_system1.58909688
31MP0002089_abnormal_postnatal_growth/wei1.57115991
32MP0004808_abnormal_hematopoietic_stem1.55820619
33MP0003984_embryonic_growth_retardation1.55035575
34MP0003119_abnormal_digestive_system1.53273140
35MP0000350_abnormal_cell_proliferation1.52051797
36MP0001293_anophthalmia1.49285228
37MP0008007_abnormal_cellular_replicative1.48748584
38MP0002697_abnormal_eye_size1.47678094
39MP0002088_abnormal_embryonic_growth/wei1.47220216
40MP0003861_abnormal_nervous_system1.46857280
41MP0009703_decreased_birth_body1.45891273
42MP0000049_abnormal_middle_ear1.45007350
43MP0003567_abnormal_fetal_cardiomyocyte1.42848689
44MP0002080_prenatal_lethality1.37121285
45MP0001697_abnormal_embryo_size1.35041575
46MP0000678_abnormal_parathyroid_gland1.34238357
47MP0004858_abnormal_nervous_system1.33484379
48MP0010352_gastrointestinal_tract_polyps1.31711476
49MP0003935_abnormal_craniofacial_develop1.31266432
50MP0002249_abnormal_larynx_morphology1.31223873
51MP0001849_ear_inflammation1.30925602
52MP0008877_abnormal_DNA_methylation1.29914402
53MP0003122_maternal_imprinting1.28360861
54MP0002111_abnormal_tail_morphology1.23160982
55MP0002086_abnormal_extraembryonic_tissu1.22305043
56MP0003115_abnormal_respiratory_system1.20869001
57MP0001348_abnormal_lacrimal_gland1.19363773
58MP0000566_synostosis1.18721219
59MP0001286_abnormal_eye_development1.17493310
60MP0004133_heterotaxia1.17450658
61MP0000432_abnormal_head_morphology1.16210845
62MP0003123_paternal_imprinting1.14389379
63MP0002116_abnormal_craniofacial_bone1.14180419
64MP0003136_yellow_coat_color1.13816923
65MP0003283_abnormal_digestive_organ1.10487097
66MP0003121_genomic_imprinting1.08348847
67MP0000733_abnormal_muscle_development1.05539229
68MP0003646_muscle_fatigue1.05251409
69MP0002092_abnormal_eye_morphology1.05156012
70MP0001299_abnormal_eye_distance/1.05040887
71MP0008995_early_reproductive_senescence1.02730071
72MP0000778_abnormal_nervous_system1.01784071
73MP0002925_abnormal_cardiovascular_devel1.00373702
74MP0003755_abnormal_palate_morphology0.99965380
75MP0010630_abnormal_cardiac_muscle0.99299727
76MP0002653_abnormal_ependyma_morphology0.97759668
77MP0002081_perinatal_lethality0.97755291
78MP0004185_abnormal_adipocyte_glucose0.97511245
79MP0002114_abnormal_axial_skeleton0.96400526
80MP0003315_abnormal_perineum_morphology0.94406385
81MP0000534_abnormal_ureter_morphology0.89148270
82MP0002233_abnormal_nose_morphology0.88994882
83MP0000313_abnormal_cell_death0.87957961
84MP0002938_white_spotting0.87545604
85MP0010307_abnormal_tumor_latency0.87276931
86MP0000751_myopathy0.82402437
87MP0002152_abnormal_brain_morphology0.81864821
88MP0002108_abnormal_muscle_morphology0.80729665
89MP0002184_abnormal_innervation0.80156860
90MP0002210_abnormal_sex_determination0.80117763
91MP0003878_abnormal_ear_physiology0.80081054
92MP0005377_hearing/vestibular/ear_phenot0.80081054
93MP0005171_absent_coat_pigmentation0.79967407
94MP0000003_abnormal_adipose_tissue0.79733881
95MP0008961_abnormal_basal_metabolism0.78419201
96MP0003938_abnormal_ear_development0.75884628
97MP0000266_abnormal_heart_morphology0.75732412
98MP0005394_taste/olfaction_phenotype0.75442967
99MP0005499_abnormal_olfactory_system0.75442967
100MP0003943_abnormal_hepatobiliary_system0.74512631

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.37507420
2Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88911707
3Birth length less than 3rd percentile (HP:0003561)2.74825684
4Acute lymphatic leukemia (HP:0006721)2.66774264
5Patellar aplasia (HP:0006443)2.66710596
6Trigonocephaly (HP:0000243)2.61571232
7Bronchomalacia (HP:0002780)2.53155256
8Increased nuchal translucency (HP:0010880)2.52870249
9High anterior hairline (HP:0009890)2.52206504
10Chromsome breakage (HP:0040012)2.51402169
11Shallow orbits (HP:0000586)2.45497898
12Renovascular hypertension (HP:0100817)2.42645004
13Turricephaly (HP:0000262)2.40858529
14Aplasia/Hypoplasia of the patella (HP:0006498)2.36949914
15Cortical dysplasia (HP:0002539)2.36711131
16Long eyelashes (HP:0000527)2.35391460
17Flat cornea (HP:0007720)2.34409156
18Dysmetric saccades (HP:0000641)2.34124476
19Abnormality of the fingertips (HP:0001211)2.31678921
20Broad thumb (HP:0011304)2.29830988
21Hepatoblastoma (HP:0002884)2.28333259
22Urethral obstruction (HP:0000796)2.27703103
23Ectopic kidney (HP:0000086)2.24296081
24Skull defect (HP:0001362)2.21618509
25Elfin facies (HP:0004428)2.20485551
26Overriding aorta (HP:0002623)2.18267458
27Broad phalanges of the hand (HP:0009768)2.16066754
28Pointed chin (HP:0000307)2.12723958
29Insomnia (HP:0100785)2.12352612
30Abnormality of the aortic arch (HP:0012303)2.12331311
31Obsessive-compulsive behavior (HP:0000722)2.10002875
32Partial agenesis of the corpus callosum (HP:0001338)2.08059535
33Broad finger (HP:0001500)2.03719405
34Bilateral microphthalmos (HP:0007633)2.03601255
35Renal duplication (HP:0000075)2.03542991
36Abnormality of the calcaneus (HP:0008364)2.03233924
37Reticulocytopenia (HP:0001896)2.03186420
38Genetic anticipation (HP:0003743)2.01439023
39Aplasia/Hypoplasia of the sternum (HP:0006714)1.99767364
40Spina bifida occulta (HP:0003298)1.96789447
41Abnormality of cochlea (HP:0000375)1.93327745
42Protruding tongue (HP:0010808)1.90904403
43Broad distal phalanx of finger (HP:0009836)1.90037945
44Disproportionate tall stature (HP:0001519)1.89151265
45Nephroblastoma (Wilms tumor) (HP:0002667)1.86772233
46Hypoplastic ischia (HP:0003175)1.84419841
4711 pairs of ribs (HP:0000878)1.84029951
48Thin ribs (HP:0000883)1.83147827
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83094754
50Abnormality of the labia minora (HP:0012880)1.82966387
51Sandal gap (HP:0001852)1.82801293
52Absent radius (HP:0003974)1.82555673
53Choanal stenosis (HP:0000452)1.82002011
54Broad phalanx (HP:0006009)1.81680961
55Abnormal number of incisors (HP:0011064)1.80682343
56Broad face (HP:0000283)1.78111683
57Morphological abnormality of the inner ear (HP:0011390)1.77420177
58Tracheomalacia (HP:0002779)1.77279855
59Broad metatarsal (HP:0001783)1.76922013
60Heterotopia (HP:0002282)1.76490843
61Chin dimple (HP:0010751)1.75348491
62Breast hypoplasia (HP:0003187)1.75221103
63Short 4th metacarpal (HP:0010044)1.73689516
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73689516
65Bowel incontinence (HP:0002607)1.72686011
66Failure to thrive in infancy (HP:0001531)1.72683170
67Hypotelorism (HP:0000601)1.71920159
68Broad long bones (HP:0005622)1.69890884
69Cutaneous syndactyly (HP:0012725)1.69398677
70Vertebral arch anomaly (HP:0008438)1.68142734
71Ankyloglossia (HP:0010296)1.67985019
72Aplasia involving forearm bones (HP:0009822)1.67490692
73Absent forearm bone (HP:0003953)1.67490692
74Embryonal renal neoplasm (HP:0011794)1.67359152
75Abnormality of the carotid arteries (HP:0005344)1.67040484
76Ependymoma (HP:0002888)1.66938380
77Abnormality of the pubic bones (HP:0003172)1.66252908
78Abnormality of homocysteine metabolism (HP:0010919)1.65725903
79Homocystinuria (HP:0002156)1.65725903
80Atresia of the external auditory canal (HP:0000413)1.65552764
81Absent epiphyses (HP:0010577)1.65115597
82Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65115597
83Selective tooth agenesis (HP:0001592)1.64610752
84Deep palmar crease (HP:0006191)1.64575516
85Overlapping toe (HP:0001845)1.64288201
86Abnormality of the ischium (HP:0003174)1.62047737
87Meckel diverticulum (HP:0002245)1.61252862
88High pitched voice (HP:0001620)1.61053022
89Cutaneous finger syndactyly (HP:0010554)1.60684699
90Abnormality of the ileum (HP:0001549)1.60137204
91Broad palm (HP:0001169)1.60126835
92Ulnar bowing (HP:0003031)1.59214216
93Asymmetry of the thorax (HP:0001555)1.59163783
94Breast aplasia (HP:0100783)1.58929713
95Arnold-Chiari malformation (HP:0002308)1.58782822
96Duplication of thumb phalanx (HP:0009942)1.58190521
97Patellar dislocation (HP:0002999)1.57988245
98Aplasia/Hypoplasia of the breasts (HP:0010311)1.57419822
99Deviation of the thumb (HP:0009603)1.56052887
100Duplicated collecting system (HP:0000081)1.55781219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.72637750
2MAP3K104.60824953
3CDK123.46530807
4TRIB33.31332901
5CDC72.99980353
6ICK2.71638362
7SMG12.41986846
8BRD42.29715580
9FLT32.18552610
10TTK2.06476869
11LATS11.98250656
12TYRO31.95595537
13NEK21.81834942
14MKNK11.67192562
15SIK11.65844451
16MTOR1.62260556
17PKN21.60688344
18FGFR41.53103951
19LATS21.51558497
20CHEK21.49329273
21MKNK21.46760051
22CAMK1D1.43571535
23SRPK11.39486522
24PDGFRA1.36494467
25NTRK11.34634861
26RPS6KB21.31542285
27SIK21.28894051
28MAP3K71.28433182
29FGFR21.25765520
30MARK21.23501283
31PASK1.22910794
32ATR1.22309912
33BMX1.21166932
34TTN1.20979869
35CDK41.20845851
36CAMK1G1.11289702
37CDK71.07972466
38CHEK11.05378076
39NME11.04326078
40CLK11.00159210
41PRKD30.97290149
42WEE10.96868401
43BUB10.94840995
44ZAK0.91583926
45PRKD20.90458840
46CDK20.89975095
47RPS6KA20.88885971
48CDK10.83939519
49MAP2K20.83579755
50CDK80.81804129
51RPS6KA10.81032918
52RPS6KL10.75255511
53RPS6KC10.75255511
54PLK40.73002158
55PRPF4B0.71571349
56PTK60.71404676
57PLK10.71063523
58RPS6KA60.69974080
59ATM0.69363704
60STK30.68848714
61DMPK0.65546980
62GSK3B0.59325523
63CDK60.59008411
64PAK20.58230626
65MAPK150.58152955
66FGFR10.57767092
67PRKAA10.54943125
68KSR20.54556759
69AKT10.54079841
70PTK20.53476293
71TSSK60.52921543
72DYRK1B0.52237299
73ALK0.51581245
74MAPK100.51550307
75DYRK20.51173585
76AURKB0.51069673
77TAF10.51042909
78KSR10.50174698
79MAPK140.49002871
80PRKDC0.48624083
81MAPK10.48614646
82HIPK20.46501090
83MAPK80.45700513
84MAPK90.45608944
85RET0.44576014
86MAP3K80.43385347
87TGFBR10.42730170
88DYRK30.42099948
89MAP3K60.42046726
90PLK30.40721696
91CSNK1E0.38805096
92TIE10.37562514
93MET0.37450496
94EPHA20.36968890
95MATK0.36168086
96RIPK10.35696091
97PAK40.35418660
98CAMK40.35385847
99MAPK30.34780478
100MAPK110.30333719

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.11150595
2mRNA surveillance pathway_Homo sapiens_hsa030152.38305660
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36716500
4Base excision repair_Homo sapiens_hsa034102.29740105
5Spliceosome_Homo sapiens_hsa030402.14827402
6Cell cycle_Homo sapiens_hsa041102.12191152
7Lysine degradation_Homo sapiens_hsa003102.10849409
8RNA transport_Homo sapiens_hsa030131.97759086
9Mismatch repair_Homo sapiens_hsa034301.89891394
10Selenocompound metabolism_Homo sapiens_hsa004501.79867812
11Chronic myeloid leukemia_Homo sapiens_hsa052201.77475985
12Basal cell carcinoma_Homo sapiens_hsa052171.70902512
13Notch signaling pathway_Homo sapiens_hsa043301.69197220
14One carbon pool by folate_Homo sapiens_hsa006701.62475633
15MicroRNAs in cancer_Homo sapiens_hsa052061.58894414
16Non-homologous end-joining_Homo sapiens_hsa034501.55959160
17Fanconi anemia pathway_Homo sapiens_hsa034601.52171351
18Homologous recombination_Homo sapiens_hsa034401.46295114
19Nucleotide excision repair_Homo sapiens_hsa034201.45871800
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44077396
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42956864
22Adherens junction_Homo sapiens_hsa045201.41986968
23Hippo signaling pathway_Homo sapiens_hsa043901.39987899
24Colorectal cancer_Homo sapiens_hsa052101.39429067
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37347752
26Thyroid cancer_Homo sapiens_hsa052161.36479143
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.36389248
28Acute myeloid leukemia_Homo sapiens_hsa052211.33216438
29Wnt signaling pathway_Homo sapiens_hsa043101.24433021
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15997253
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14634230
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11284046
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11124268
34ErbB signaling pathway_Homo sapiens_hsa040121.04656790
35Prostate cancer_Homo sapiens_hsa052151.04347488
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04306273
37Endometrial cancer_Homo sapiens_hsa052131.03500314
38Bladder cancer_Homo sapiens_hsa052191.02865273
39Melanoma_Homo sapiens_hsa052181.02299453
40Biosynthesis of amino acids_Homo sapiens_hsa012300.99801757
41Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97834025
42Non-small cell lung cancer_Homo sapiens_hsa052230.95735753
43Vitamin B6 metabolism_Homo sapiens_hsa007500.94332105
44Basal transcription factors_Homo sapiens_hsa030220.92975524
45Melanogenesis_Homo sapiens_hsa049160.90246046
46Glioma_Homo sapiens_hsa052140.87432955
47Hedgehog signaling pathway_Homo sapiens_hsa043400.87352596
48mTOR signaling pathway_Homo sapiens_hsa041500.86207928
49Pathways in cancer_Homo sapiens_hsa052000.85116615
50AMPK signaling pathway_Homo sapiens_hsa041520.82132019
51Pancreatic cancer_Homo sapiens_hsa052120.81791259
52Axon guidance_Homo sapiens_hsa043600.80346997
53VEGF signaling pathway_Homo sapiens_hsa043700.80314118
54Viral carcinogenesis_Homo sapiens_hsa052030.79420038
55RNA degradation_Homo sapiens_hsa030180.78958668
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78719670
57Small cell lung cancer_Homo sapiens_hsa052220.77713652
58Insulin signaling pathway_Homo sapiens_hsa049100.77583573
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77417209
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77340201
61Choline metabolism in cancer_Homo sapiens_hsa052310.75059885
62TGF-beta signaling pathway_Homo sapiens_hsa043500.74446486
63p53 signaling pathway_Homo sapiens_hsa041150.74410983
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.73440192
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.72077127
66Focal adhesion_Homo sapiens_hsa045100.71826465
67Long-term depression_Homo sapiens_hsa047300.71715025
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68636536
69ECM-receptor interaction_Homo sapiens_hsa045120.67222507
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.67176746
71Tight junction_Homo sapiens_hsa045300.66838327
72Pyrimidine metabolism_Homo sapiens_hsa002400.64679373
73HTLV-I infection_Homo sapiens_hsa051660.64180591
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63933504
75RNA polymerase_Homo sapiens_hsa030200.63916281
76Renal cell carcinoma_Homo sapiens_hsa052110.63066922
77Estrogen signaling pathway_Homo sapiens_hsa049150.62774357
78Inositol phosphate metabolism_Homo sapiens_hsa005620.62529521
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.62519130
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61662561
81Gap junction_Homo sapiens_hsa045400.60505787
82Steroid biosynthesis_Homo sapiens_hsa001000.59996623
83N-Glycan biosynthesis_Homo sapiens_hsa005100.59708231
84Nicotine addiction_Homo sapiens_hsa050330.59399747
85Oocyte meiosis_Homo sapiens_hsa041140.58824923
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58135117
87Proteoglycans in cancer_Homo sapiens_hsa052050.57632453
88Hepatitis B_Homo sapiens_hsa051610.56949388
89MAPK signaling pathway_Homo sapiens_hsa040100.56276836
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54783292
91Prolactin signaling pathway_Homo sapiens_hsa049170.54238835
92Alcoholism_Homo sapiens_hsa050340.51104801
93Glucagon signaling pathway_Homo sapiens_hsa049220.50924621
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50405455
95Thyroid hormone synthesis_Homo sapiens_hsa049180.50260850
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49580085
97Dilated cardiomyopathy_Homo sapiens_hsa054140.49504699
98Type II diabetes mellitus_Homo sapiens_hsa049300.49474328
99Taste transduction_Homo sapiens_hsa047420.49425113
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48776465

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