ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.67270645
2	regulation of meiosis I (GO:0060631)	4.64627878
3	presynaptic membrane assembly (GO:0097105)	4.19061021
4	piRNA metabolic process (GO:0034587)	4.15505743
5	DNA double-strand break processing (GO:0000729)	3.90858774
6	somite rostral/caudal axis specification (GO:0032525)	3.87915888
7	synapsis (GO:0007129)	3.85103550
8	retinal cone cell development (GO:0046549)	3.77652731
9	peptidyl-histidine modification (GO:0018202)	3.69713979
10	presynaptic membrane organization (GO:0097090)	3.58603197
11	glycine transport (GO:0015816)	3.53035739
12	DNA methylation involved in gamete generation (GO:0043046)	3.51138304
13	positive regulation of meiosis (GO:0045836)	3.46094775
14	gamma-aminobutyric acid transport (GO:0015812)	3.45595678
15	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.39918067
16	cilium morphogenesis (GO:0060271)	3.31127735
17	regulation of DNA methylation (GO:0044030)	3.28322941
18	cullin deneddylation (GO:0010388)	3.27418220
19	nonmotile primary cilium assembly (GO:0035058)	3.25768894
20	male meiosis (GO:0007140)	3.25411886
21	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.23207682
22	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.23207682
23	positive regulation of meiotic cell cycle (GO:0051446)	3.19662480
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16398222
25	intraciliary transport (GO:0042073)	3.16028288
26	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.12028034
27	neural tube formation (GO:0001841)	3.06762854
28	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.05639065
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.00203760
30	protein-cofactor linkage (GO:0018065)	2.97264253
31	respiratory chain complex IV assembly (GO:0008535)	2.95950992
32	L-fucose catabolic process (GO:0042355)	2.95252522
33	fucose catabolic process (GO:0019317)	2.95252522
34	L-fucose metabolic process (GO:0042354)	2.95252522
35	neuron fate determination (GO:0048664)	2.95204612
36	L-methionine salvage (GO:0071267)	2.94972082
37	L-methionine biosynthetic process (GO:0071265)	2.94972082
38	amino acid salvage (GO:0043102)	2.94972082
39	regulation of male gonad development (GO:2000018)	2.93598607
40	spermatid nucleus differentiation (GO:0007289)	2.89765167
41	polyol catabolic process (GO:0046174)	2.88866604
42	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.86603037
43	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.86603037
44	resolution of meiotic recombination intermediates (GO:0000712)	2.83235156
45	centriole replication (GO:0007099)	2.80064432
46	regulation of feeding behavior (GO:0060259)	2.79991885
47	regulation of cilium movement (GO:0003352)	2.79783749
48	inner ear receptor stereocilium organization (GO:0060122)	2.77465324
49	replication fork processing (GO:0031297)	2.77055818
50	regulation of acrosome reaction (GO:0060046)	2.73557827
51	lactate metabolic process (GO:0006089)	2.71656447
52	intra-S DNA damage checkpoint (GO:0031573)	2.71136302
53	meiotic cell cycle (GO:0051321)	2.70615600
54	head development (GO:0060322)	2.70268420
55	recombinational repair (GO:0000725)	2.67814197
56	male meiosis I (GO:0007141)	2.67782349
57	photoreceptor cell maintenance (GO:0045494)	2.67692958
58	cerebral cortex radially oriented cell migration (GO:0021799)	2.67448522
59	negative regulation of mast cell activation (GO:0033004)	2.66722487
60	double-strand break repair via homologous recombination (GO:0000724)	2.66286952
61	methionine biosynthetic process (GO:0009086)	2.64539517
62	microtubule anchoring (GO:0034453)	2.63779524
63	methionine metabolic process (GO:0006555)	2.62575069
64	DNA integration (GO:0015074)	2.62059424
65	protein deneddylation (GO:0000338)	2.61985833
66	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.61909395
67	reciprocal meiotic recombination (GO:0007131)	2.58798509
68	reciprocal DNA recombination (GO:0035825)	2.58798509
69	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.58663736
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.58663736
71	NADH dehydrogenase complex assembly (GO:0010257)	2.58663736
72	acrosome assembly (GO:0001675)	2.57127464
73	kinetochore organization (GO:0051383)	2.56963138
74	epithelial cilium movement (GO:0003351)	2.54699695
75	neuron cell-cell adhesion (GO:0007158)	2.51190273
76	postsynaptic membrane organization (GO:0001941)	2.49065557
77	regulation of action potential (GO:0098900)	2.48645125
78	cilium organization (GO:0044782)	2.48294267
79	regulation of helicase activity (GO:0051095)	2.48268069
80	attachment of spindle microtubules to kinetochore (GO:0008608)	2.47187384
81	protein polyglutamylation (GO:0018095)	2.46500954
82	cilium assembly (GO:0042384)	2.45991468
83	outer ear morphogenesis (GO:0042473)	2.45713760
84	positive regulation of mitochondrial fission (GO:0090141)	2.43427899
85	vocalization behavior (GO:0071625)	2.40290071
86	auditory receptor cell stereocilium organization (GO:0060088)	2.37193713
87	regulation of development, heterochronic (GO:0040034)	2.36475025
88	chromosome organization involved in meiosis (GO:0070192)	2.35764118
89	limb bud formation (GO:0060174)	2.35445272
90	protein complex biogenesis (GO:0070271)	2.33874004
91	pyrimidine nucleobase catabolic process (GO:0006208)	2.33151404
92	photoreceptor cell development (GO:0042461)	2.32590500
93	regulation of DNA endoreduplication (GO:0032875)	2.32229097
94	peptidyl-lysine trimethylation (GO:0018023)	2.31345142
95	positive regulation of gastrulation (GO:2000543)	2.30209440
96	meiotic chromosome segregation (GO:0045132)	2.29275530
97	regulation of hexokinase activity (GO:1903299)	2.29171778
98	regulation of glucokinase activity (GO:0033131)	2.29171778
99	tachykinin receptor signaling pathway (GO:0007217)	2.28720011
100	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.28180395

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.83167595
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.28558261
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.16420164
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.04348987
5	VDR_22108803_ChIP-Seq_LS180_Human	2.96939317
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.82415280
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77084734
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71751747
9	FUS_26573619_Chip-Seq_HEK293_Human	2.70763611
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.65767180
11	EWS_26573619_Chip-Seq_HEK293_Human	2.53228063
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44231567
13	P300_19829295_ChIP-Seq_ESCs_Human	2.23104097
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.21653024
15	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00886801
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94946713
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92451338
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.92116254
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.85301131
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.82173596
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.81175870
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79344371
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.78659880
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77231527
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76117355
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.74052668
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72916078
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71665015
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.71164204
30	* MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66213497
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.65303325
32	* IRF1_19129219_ChIP-ChIP_H3396_Human	1.63220050
33	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60469934
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59360601
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.58971451
36	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56836150
37	STAT3_23295773_ChIP-Seq_U87_Human	1.56539060
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54229438
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51394045
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.50763153
41	AR_25329375_ChIP-Seq_VCAP_Human	1.49446033
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49107859
43	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.45491216
44	TCF4_23295773_ChIP-Seq_U87_Human	1.42317511
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41383514
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39297760
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.39278540
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38593206
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.37208054
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35383410
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.35123489
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.34326830
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32108661
54	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.31917387
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30860042
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30674981
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.30674981
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28912875
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27478376
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.26119419
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25834936
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25834936
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22472801
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21878551
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21878551
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20127770
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19865362
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17670553
69	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16265401
70	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.16222544
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14847545
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14467409
73	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13989623
74	JUN_21703547_ChIP-Seq_K562_Human	1.13831313
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12321235
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12094708
77	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12070172
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.11776748
79	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11620249
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10374950
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09592748
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.09147116
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08019714
84	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06723671
85	VDR_23849224_ChIP-Seq_CD4+_Human	1.06148797
86	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.05487417
87	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04934493
88	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04254571
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99721915
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98120752
91	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97596755
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.97266752
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96415251
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96173632
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94838850
96	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.94488160
97	REST_21632747_ChIP-Seq_MESCs_Mouse	0.93033278
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92270983
99	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91217402
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91148644

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.16963646
2	MP0006292_abnormal_olfactory_placode	3.01652585
3	MP0008058_abnormal_DNA_repair	2.97567282
4	MP0003718_maternal_effect	2.57006331
5	MP0009780_abnormal_chondrocyte_physiolo	2.34104515
6	MP0008789_abnormal_olfactory_epithelium	2.31455505
7	MP0002102_abnormal_ear_morphology	2.28594675
8	MP0002234_abnormal_pharynx_morphology	2.08145071
9	MP0003890_abnormal_embryonic-extraembry	2.03995318
10	MP0006054_spinal_hemorrhage	2.01065503
11	MP0005551_abnormal_eye_electrophysiolog	1.96506106
12	MP0004043_abnormal_pH_regulation	1.95856711
13	MP0004142_abnormal_muscle_tone	1.94519269
14	MP0004133_heterotaxia	1.84998678
15	MP0001986_abnormal_taste_sensitivity	1.81095224
16	MP0001486_abnormal_startle_reflex	1.79859694
17	MP0003567_abnormal_fetal_cardiomyocyte	1.76232576
18	MP0000049_abnormal_middle_ear	1.75822456
19	MP0000647_abnormal_sebaceous_gland	1.74324878
20	MP0003787_abnormal_imprinting	1.73790861
21	MP0000631_abnormal_neuroendocrine_gland	1.73353006
22	MP0003121_genomic_imprinting	1.72607134
23	MP0005394_taste/olfaction_phenotype	1.70522017
24	MP0005499_abnormal_olfactory_system	1.70522017
25	MP0008995_early_reproductive_senescence	1.61754537
26	MP0003136_yellow_coat_color	1.61655147
27	MP0002837_dystrophic_cardiac_calcinosis	1.59833739
28	MP0000427_abnormal_hair_cycle	1.52068198
29	MP0008057_abnormal_DNA_replication	1.51758222
30	MP0000383_abnormal_hair_follicle	1.50305438
31	MP0003119_abnormal_digestive_system	1.49957945
32	MP0004885_abnormal_endolymph	1.47401505
33	MP0001501_abnormal_sleep_pattern	1.45762090
34	MP0009745_abnormal_behavioral_response	1.41250074
35	MP0002233_abnormal_nose_morphology	1.40857929
36	MP0006072_abnormal_retinal_apoptosis	1.39819232
37	MP0010094_abnormal_chromosome_stability	1.37074925
38	MP0004145_abnormal_muscle_electrophysio	1.36276476
39	MP0003755_abnormal_palate_morphology	1.36027201
40	MP0002736_abnormal_nociception_after	1.34009508
41	MP0005187_abnormal_penis_morphology	1.32207149
42	MP0005379_endocrine/exocrine_gland_phen	1.31666310
43	MP0002272_abnormal_nervous_system	1.30935864
44	MP0008961_abnormal_basal_metabolism	1.29957124
45	MP0006276_abnormal_autonomic_nervous	1.29332370
46	MP0003937_abnormal_limbs/digits/tail_de	1.28593274
47	MP0002735_abnormal_chemical_nociception	1.28295964
48	MP0003880_abnormal_central_pattern	1.25026339
49	MP0005253_abnormal_eye_physiology	1.23359051
50	MP0003283_abnormal_digestive_organ	1.22492464
51	MP0002210_abnormal_sex_determination	1.21658491
52	MP0001929_abnormal_gametogenesis	1.18613336
53	MP0001188_hyperpigmentation	1.17429112
54	MP0002876_abnormal_thyroid_physiology	1.16442901
55	MP0001968_abnormal_touch/_nociception	1.16012456
56	MP0000653_abnormal_sex_gland	1.15906403
57	MP0000778_abnormal_nervous_system	1.15595572
58	MP0001529_abnormal_vocalization	1.13428656
59	MP0004134_abnormal_chest_morphology	1.11623333
60	MP0001293_anophthalmia	1.10651993
61	MP0004215_abnormal_myocardial_fiber	1.09496009
62	MP0002734_abnormal_mechanical_nocicepti	1.09126351
63	MP0009046_muscle_twitch	1.08483721
64	MP0001984_abnormal_olfaction	1.08271048
65	MP0002928_abnormal_bile_duct	1.08181283
66	MP0003635_abnormal_synaptic_transmissio	1.05678473
67	MP0002638_abnormal_pupillary_reflex	1.04788006
68	MP0010678_abnormal_skin_adnexa	1.03807663
69	MP0003698_abnormal_male_reproductive	1.03245710
70	MP0002751_abnormal_autonomic_nervous	1.03141710
71	MP0002163_abnormal_gland_morphology	1.03013138
72	MP0002572_abnormal_emotion/affect_behav	1.01387846
73	MP0004147_increased_porphyrin_level	1.00709173
74	MP0004924_abnormal_behavior	1.00659510
75	MP0005386_behavior/neurological_phenoty	1.00659510
76	MP0002653_abnormal_ependyma_morphology	0.99061028
77	MP0005084_abnormal_gallbladder_morpholo	0.98105512
78	MP0009250_abnormal_appendicular_skeleto	0.97688105
79	MP0002938_white_spotting	0.97624060
80	MP0004270_analgesia	0.95176666
81	MP0003385_abnormal_body_wall	0.93561627
82	MP0002557_abnormal_social/conspecific_i	0.93204845
83	MP0000462_abnormal_digestive_system	0.93190103
84	MP0001145_abnormal_male_reproductive	0.93097841
85	MP0005248_abnormal_Harderian_gland	0.92071922
86	MP0002095_abnormal_skin_pigmentation	0.91657381
87	MP0001286_abnormal_eye_development	0.91299432
88	MP0003938_abnormal_ear_development	0.90237499
89	MP0001299_abnormal_eye_distance/	0.89444522
90	MP0000566_synostosis	0.89171374
91	MP0000013_abnormal_adipose_tissue	0.85712624
92	MP0005195_abnormal_posterior_eye	0.85440259
93	MP0005646_abnormal_pituitary_gland	0.84997555
94	MP0003786_premature_aging	0.83555610
95	MP0002752_abnormal_somatic_nervous	0.83335903
96	MP0000026_abnormal_inner_ear	0.81764143
97	MP0003646_muscle_fatigue	0.81749504
98	MP0002177_abnormal_outer_ear	0.80635881
99	MP0000613_abnormal_salivary_gland	0.80581096
100	MP0001119_abnormal_female_reproductive	0.79974438

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.95399546
2	Pancreatic fibrosis (HP:0100732)	3.76391401
3	Colon cancer (HP:0003003)	3.53862068
4	Pancreatic cysts (HP:0001737)	3.48916538
5	Molar tooth sign on MRI (HP:0002419)	3.41825450
6	Abnormality of midbrain morphology (HP:0002418)	3.41825450
7	Medial flaring of the eyebrow (HP:0010747)	3.40263936
8	True hermaphroditism (HP:0010459)	3.33647314
9	Nephronophthisis (HP:0000090)	3.27701436
10	Gait imbalance (HP:0002141)	3.07514103
11	Supernumerary spleens (HP:0009799)	3.05439689
12	Congenital primary aphakia (HP:0007707)	3.03447441
13	Nephrogenic diabetes insipidus (HP:0009806)	2.97994393
14	Abnormality of the labia minora (HP:0012880)	2.89928749
15	Volvulus (HP:0002580)	2.87607683
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.79576530
17	Chronic hepatic failure (HP:0100626)	2.76618229
18	Calf muscle hypertrophy (HP:0008981)	2.76383707
19	Abnormality of the renal medulla (HP:0100957)	2.75118695
20	Bile duct proliferation (HP:0001408)	2.67614379
21	Abnormal biliary tract physiology (HP:0012439)	2.67614379
22	Progressive macrocephaly (HP:0004481)	2.57809404
23	Protruding tongue (HP:0010808)	2.57197266
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.57029370
25	Acute necrotizing encephalopathy (HP:0006965)	2.55754134
26	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.51831177
27	Muscle hypertrophy of the lower extremities (HP:0008968)	2.47829377
28	Genital tract atresia (HP:0001827)	2.47359502
29	Attenuation of retinal blood vessels (HP:0007843)	2.43754599
30	Intestinal atresia (HP:0011100)	2.42829199
31	Broad-based gait (HP:0002136)	2.37400282
32	Aplasia/hypoplasia of the uterus (HP:0008684)	2.37170522
33	Vaginal atresia (HP:0000148)	2.36395182
34	Acute encephalopathy (HP:0006846)	2.34924306
35	Papillary thyroid carcinoma (HP:0002895)	2.33626713
36	Methylmalonic acidemia (HP:0002912)	2.33163537
37	Median cleft lip (HP:0000161)	2.29884921
38	Hepatocellular necrosis (HP:0001404)	2.24521507
39	Shoulder girdle muscle weakness (HP:0003547)	2.17223986
40	Congenital stationary night blindness (HP:0007642)	2.17099660
41	Sclerocornea (HP:0000647)	2.14303878
42	Atonic seizures (HP:0010819)	2.13175270
43	Medulloblastoma (HP:0002885)	2.12778920
44	Stomach cancer (HP:0012126)	2.12286537
45	Cystic liver disease (HP:0006706)	2.10814189
46	Increased CSF lactate (HP:0002490)	2.10382479
47	Absent speech (HP:0001344)	2.10194695
48	Hyperglycinemia (HP:0002154)	2.08067654
49	Narrow forehead (HP:0000341)	2.07174152
50	Neoplasm of the oral cavity (HP:0100649)	2.07012091
51	Mitochondrial inheritance (HP:0001427)	2.05905599
52	Drooling (HP:0002307)	2.02711509
53	Abnormality of the renal cortex (HP:0011035)	1.99595773
54	Hypoplastic labia majora (HP:0000059)	1.99349680
55	Abnormal mitochondria in muscle tissue (HP:0008316)	1.98871599
56	CNS hypomyelination (HP:0003429)	1.97815943
57	Bony spicule pigmentary retinopathy (HP:0007737)	1.95105463
58	Asplenia (HP:0001746)	1.94386649
59	Congenital hepatic fibrosis (HP:0002612)	1.94329043
60	Gaze-evoked nystagmus (HP:0000640)	1.93123988
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.92621604
62	Hepatic necrosis (HP:0002605)	1.91792464
63	Abnormality of the musculature of the pelvis (HP:0001469)	1.91278005
64	Abnormality of the hip-girdle musculature (HP:0001445)	1.91278005
65	Poor coordination (HP:0002370)	1.90377472
66	Split foot (HP:0001839)	1.89437716
67	Septo-optic dysplasia (HP:0100842)	1.88689746
68	Male pseudohermaphroditism (HP:0000037)	1.86939174
69	Unsteady gait (HP:0002317)	1.84244656
70	Anencephaly (HP:0002323)	1.84160975
71	Sloping forehead (HP:0000340)	1.83630783
72	Pendular nystagmus (HP:0012043)	1.82354026
73	Hyperglycinuria (HP:0003108)	1.82288992
74	Furrowed tongue (HP:0000221)	1.80232702
75	Rhabdomyosarcoma (HP:0002859)	1.80223239
76	Abnormality of the labia majora (HP:0012881)	1.80059057
77	Decreased testicular size (HP:0008734)	1.79753817
78	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79400061
79	Excessive salivation (HP:0003781)	1.78240382
80	Postaxial foot polydactyly (HP:0001830)	1.76599904
81	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.74360085
82	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.74360085
83	Abnormality of the metopic suture (HP:0005556)	1.74323039
84	Adrenal hypoplasia (HP:0000835)	1.74291710
85	Tubular atrophy (HP:0000092)	1.73172663
86	Abnormality of vitamin B metabolism (HP:0004340)	1.72774388
87	Aplasia/Hypoplasia of the lens (HP:0008063)	1.72545478
88	Astigmatism (HP:0000483)	1.71908762
89	Postaxial hand polydactyly (HP:0001162)	1.71455812
90	Thyroid carcinoma (HP:0002890)	1.71056142
91	Hemiparesis (HP:0001269)	1.69557396
92	Glioma (HP:0009733)	1.67221872
93	Abnormality of glycine metabolism (HP:0010895)	1.66125369
94	Abnormality of serine family amino acid metabolism (HP:0010894)	1.66125369
95	Cerebral edema (HP:0002181)	1.65574664
96	Broad foot (HP:0001769)	1.65430564
97	Abnormal lung lobation (HP:0002101)	1.63919221
98	Widely spaced teeth (HP:0000687)	1.63918100
99	Optic disc pallor (HP:0000543)	1.62990650
100	Absent septum pellucidum (HP:0001331)	1.62820962

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.29931918
2	FRK	3.15893196
3	TNIK	2.97067793
4	MAP3K4	2.62155928
5	ACVR1B	2.35761575
6	PINK1	2.22513949
7	BRSK2	2.15450023
8	STK38L	2.11671227
9	WNK3	2.06805592
10	GRK1	1.92488056
11	EIF2AK3	1.91552089
12	BMPR1B	1.86638856
13	PNCK	1.86398232
14	NUAK1	1.73759070
15	MAPK13	1.72369942
16	CCNB1	1.69825272
17	NEK1	1.60339927
18	MAP2K7	1.55851649
19	MKNK2	1.53490695
20	BRD4	1.47776058
21	CSNK1G1	1.43689703
22	MAP4K2	1.40193977
23	ADRBK2	1.39473376
24	PHKG1	1.37041957
25	PHKG2	1.37041957
26	CSNK1G2	1.28366348
27	ZAK	1.26488659
28	MARK1	1.18779646
29	SRPK1	1.10024259
30	CSNK1G3	1.09090819
31	PLK3	1.08289672
32	PRKCE	1.08028811
33	AKT3	1.05514341
34	MAP3K9	1.02221414
35	NLK	1.01906022
36	STK16	1.01628668
37	MAP2K4	1.00147773
38	ERBB3	0.98576079
39	CSNK1A1L	0.97383969
40	MKNK1	0.97180923
41	PAK3	0.95129672
42	PLK2	0.93292948
43	INSRR	0.92733846
44	TRIM28	0.92240723
45	TGFBR1	0.92042563
46	EIF2AK1	0.89170636
47	OBSCN	0.88688251
48	MAP3K6	0.87883144
49	WEE1	0.87369428
50	TTK	0.86836061
51	PRKCG	0.86525113
52	FLT3	0.85352701
53	NTRK2	0.85097781
54	VRK1	0.84652554
55	MET	0.83842223
56	CDC7	0.83322128
57	SGK2	0.83297132
58	RPS6KA4	0.81386876
59	EPHA4	0.80331104
60	ARAF	0.78928399
61	BRAF	0.78079082
62	TAF1	0.77467182
63	FGFR2	0.74915310
64	PLK1	0.74009646
65	DYRK2	0.73693907
66	BUB1	0.70609903
67	BCR	0.70076873
68	BRSK1	0.69606390
69	WNK4	0.65994180
70	STK39	0.65690919
71	STK3	0.65045995
72	ATM	0.62437660
73	PRKCI	0.59458732
74	PASK	0.59130146
75	PRKG1	0.55264529
76	PLK4	0.55246130
77	FGFR1	0.54898024
78	MST4	0.53241222
79	DYRK3	0.52733111
80	NTRK3	0.52420983
81	CSNK1E	0.51810170
82	NEK6	0.48536468
83	MUSK	0.46998867
84	PRKACB	0.46832688
85	SGK223	0.46266900
86	SGK494	0.46266900
87	TSSK6	0.44914260
88	PKN1	0.44219525
89	PIK3CA	0.44040103
90	ADRBK1	0.42545798
91	CAMKK2	0.42465578
92	PRKD3	0.42175741
93	PRKACA	0.40801901
94	CDK19	0.39418403
95	CSNK1D	0.39376126
96	NEK2	0.38617967
97	EIF2AK2	0.37501183
98	KSR1	0.36022534
99	MATK	0.35257811
100	OXSR1	0.35120306

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	2.88975691
2	Non-homologous end-joining_Homo sapiens_hsa03450	2.77852496
3	Nicotine addiction_Homo sapiens_hsa05033	2.54150049
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47437071
5	Phototransduction_Homo sapiens_hsa04744	2.45259188
6	Homologous recombination_Homo sapiens_hsa03440	2.38467759
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37448873
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23802637
9	Propanoate metabolism_Homo sapiens_hsa00640	2.23169369
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.22644191
11	Caffeine metabolism_Homo sapiens_hsa00232	2.12569459
12	Protein export_Homo sapiens_hsa03060	1.96262226
13	RNA degradation_Homo sapiens_hsa03018	1.94781379
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.91568171
15	Mismatch repair_Homo sapiens_hsa03430	1.90865959
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.90532239
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.76720827
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.65843414
19	RNA polymerase_Homo sapiens_hsa03020	1.63870815
20	RNA transport_Homo sapiens_hsa03013	1.62946082
21	Butanoate metabolism_Homo sapiens_hsa00650	1.54922641
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.54770039
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.54164653
24	Parkinsons disease_Homo sapiens_hsa05012	1.53364603
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.53273847
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47135085
27	Circadian rhythm_Homo sapiens_hsa04710	1.41827589
28	Taste transduction_Homo sapiens_hsa04742	1.41559875
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33870390
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.33705789
31	One carbon pool by folate_Homo sapiens_hsa00670	1.31538034
32	Huntingtons disease_Homo sapiens_hsa05016	1.25006147
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21386983
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20293956
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.17238673
36	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.15522535
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.13875454
38	Base excision repair_Homo sapiens_hsa03410	1.13550093
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12453042
40	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.09682012
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08816006
42	Proteasome_Homo sapiens_hsa03050	1.06939606
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06881064
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04140602
45	Basal cell carcinoma_Homo sapiens_hsa05217	0.98034551
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95096575
47	Peroxisome_Homo sapiens_hsa04146	0.93156931
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.92533215
49	GABAergic synapse_Homo sapiens_hsa04727	0.90938527
50	Purine metabolism_Homo sapiens_hsa00230	0.90761192
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89647540
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88299061
53	Alzheimers disease_Homo sapiens_hsa05010	0.85955225
54	Insulin secretion_Homo sapiens_hsa04911	0.85343756
55	Cell cycle_Homo sapiens_hsa04110	0.85233317
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.82815690
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82722779
58	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.82414416
59	Olfactory transduction_Homo sapiens_hsa04740	0.81526385
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80714972
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.80642386
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80423715
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.79202945
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78933885
65	mRNA surveillance pathway_Homo sapiens_hsa03015	0.77451906
66	Oocyte meiosis_Homo sapiens_hsa04114	0.77066477
67	Regulation of autophagy_Homo sapiens_hsa04140	0.76413316
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75106630
69	Retinol metabolism_Homo sapiens_hsa00830	0.73842695
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73673776
71	Long-term depression_Homo sapiens_hsa04730	0.72974047
72	Morphine addiction_Homo sapiens_hsa05032	0.70600499
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.70161501
74	Serotonergic synapse_Homo sapiens_hsa04726	0.69686711
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68129813
76	Spliceosome_Homo sapiens_hsa03040	0.66906012
77	Folate biosynthesis_Homo sapiens_hsa00790	0.63814142
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.63431983
79	Metabolic pathways_Homo sapiens_hsa01100	0.63182717
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.62494427
81	Circadian entrainment_Homo sapiens_hsa04713	0.61087542
82	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.58268321
83	p53 signaling pathway_Homo sapiens_hsa04115	0.57931200
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57636012
85	DNA replication_Homo sapiens_hsa03030	0.56347905
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55929525
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55906667
88	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.52061267
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.51677370
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51429247
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51170035
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.50348712
93	Amphetamine addiction_Homo sapiens_hsa05031	0.48168720
94	Sulfur metabolism_Homo sapiens_hsa00920	0.47128217
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.46116589
96	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.44574440
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44341988
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42505590
99	Glutathione metabolism_Homo sapiens_hsa00480	0.41732905
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.38685378

ZNF502

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »