ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.84784304
2	L-fucose catabolic process (GO:0042355)	4.36347446
3	fucose catabolic process (GO:0019317)	4.36347446
4	L-fucose metabolic process (GO:0042354)	4.36347446
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.03739035
6	kidney morphogenesis (GO:0060993)	3.98049506
7	response to pheromone (GO:0019236)	3.94181068
8	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.73112720
9	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.73112720
10	regulation of translation, ncRNA-mediated (GO:0045974)	3.73112720
11	DNA deamination (GO:0045006)	3.59498922
12	indole-containing compound catabolic process (GO:0042436)	3.54491908
13	indolalkylamine catabolic process (GO:0046218)	3.54491908
14	tryptophan catabolic process (GO:0006569)	3.54491908
15	gamma-aminobutyric acid transport (GO:0015812)	3.49648146
16	urinary tract smooth muscle contraction (GO:0014848)	3.46161715
17	negative regulation of telomere maintenance (GO:0032205)	3.42715358
18	cellular ketone body metabolic process (GO:0046950)	3.42213411
19	kynurenine metabolic process (GO:0070189)	3.39664391
20	indolalkylamine metabolic process (GO:0006586)	3.38042949
21	neural tube formation (GO:0001841)	3.32207316
22	peristalsis (GO:0030432)	3.28113195
23	atrial cardiac muscle cell action potential (GO:0086014)	3.26926124
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.25612900
25	neuronal action potential (GO:0019228)	3.20746674
26	primary amino compound metabolic process (GO:1901160)	3.16509228
27	regulation of gene silencing by RNA (GO:0060966)	3.16172399
28	regulation of posttranscriptional gene silencing (GO:0060147)	3.16172399
29	regulation of gene silencing by miRNA (GO:0060964)	3.16172399
30	serotonin metabolic process (GO:0042428)	3.15835209
31	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14307243
32	postsynaptic membrane organization (GO:0001941)	3.14052920
33	sulfation (GO:0051923)	3.12285150
34	epithelial cilium movement (GO:0003351)	3.09599704
35	positive regulation of CREB transcription factor activity (GO:0032793)	3.08452515
36	ketone body metabolic process (GO:1902224)	3.03353836
37	indole-containing compound metabolic process (GO:0042430)	3.02001319
38	detection of light stimulus involved in visual perception (GO:0050908)	2.99473270
39	detection of light stimulus involved in sensory perception (GO:0050962)	2.99473270
40	protein polyglutamylation (GO:0018095)	2.98787232
41	regulation of hippo signaling (GO:0035330)	2.95161102
42	nonmotile primary cilium assembly (GO:0035058)	2.93726595
43	cornea development in camera-type eye (GO:0061303)	2.92323845
44	tryptophan metabolic process (GO:0006568)	2.89454072
45	presynaptic membrane assembly (GO:0097105)	2.87337527
46	piRNA metabolic process (GO:0034587)	2.84981457
47	nucleobase catabolic process (GO:0046113)	2.81433601
48	negative regulation of interleukin-1 beta production (GO:0032691)	2.81328350
49	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.79866158
50	cilium or flagellum-dependent cell motility (GO:0001539)	2.78533487
51	regulation of action potential (GO:0098900)	2.74952776
52	spinal cord motor neuron differentiation (GO:0021522)	2.73149666
53	reflex (GO:0060004)	2.72099650
54	negative regulation of mast cell activation (GO:0033004)	2.71408471
55	regulation of telomere maintenance (GO:0032204)	2.70315920
56	cilium movement (GO:0003341)	2.68823375
57	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.68277853
58	behavioral response to ethanol (GO:0048149)	2.66233054
59	regulation of microtubule-based movement (GO:0060632)	2.66008718
60	neuron cell-cell adhesion (GO:0007158)	2.65681329
61	interkinetic nuclear migration (GO:0022027)	2.64981377
62	regulation of mesoderm development (GO:2000380)	2.63402800
63	rRNA catabolic process (GO:0016075)	2.62972478
64	phasic smooth muscle contraction (GO:0014821)	2.61012308
65	negative regulation of systemic arterial blood pressure (GO:0003085)	2.59187325
66	negative regulation of interleukin-1 production (GO:0032692)	2.57811793
67	multicellular organism reproduction (GO:0032504)	2.56572677
68	axoneme assembly (GO:0035082)	2.56433215
69	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.56347600
70	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.55157636
71	regulation of respiratory system process (GO:0044065)	2.52186973
72	membrane depolarization during action potential (GO:0086010)	2.50997138
73	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.50659599
74	platelet dense granule organization (GO:0060155)	2.50612785
75	musculoskeletal movement (GO:0050881)	2.48644369
76	multicellular organismal movement (GO:0050879)	2.48644369
77	presynaptic membrane organization (GO:0097090)	2.47830543
78	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47452845
79	cilium organization (GO:0044782)	2.46886025
80	rhodopsin mediated signaling pathway (GO:0016056)	2.46721516
81	DNA methylation involved in gamete generation (GO:0043046)	2.45832745
82	amine catabolic process (GO:0009310)	2.45636483
83	cellular biogenic amine catabolic process (GO:0042402)	2.45636483
84	regulation of cilium movement (GO:0003352)	2.45443803
85	cAMP catabolic process (GO:0006198)	2.43962688
86	positive regulation of defense response to virus by host (GO:0002230)	2.42694086
87	cilium morphogenesis (GO:0060271)	2.42528902
88	action potential (GO:0001508)	2.41837156
89	endoderm formation (GO:0001706)	2.40968894
90	cytidine metabolic process (GO:0046087)	2.40118964
91	cytidine catabolic process (GO:0006216)	2.40118964
92	cytidine deamination (GO:0009972)	2.40118964
93	cilium assembly (GO:0042384)	2.39688851
94	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.39358606
95	transmission of nerve impulse (GO:0019226)	2.38716685
96	positive regulation of action potential (GO:0045760)	2.38465938
97	vocalization behavior (GO:0071625)	2.37878748
98	positive regulation of guanylate cyclase activity (GO:0031284)	2.37319717
99	auditory behavior (GO:0031223)	2.36872530
100	synaptic transmission, cholinergic (GO:0007271)	2.36776405

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.84680549
2	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.74774053
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.12409721
4	VDR_22108803_ChIP-Seq_LS180_Human	2.98378248
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.86043876
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.67020479
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50061020
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20785128
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18516091
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09425989
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.05630894
12	TAF15_26573619_Chip-Seq_HEK293_Human	1.93657029
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.90616075
14	P300_19829295_ChIP-Seq_ESCs_Human	1.87382806
15	EWS_26573619_Chip-Seq_HEK293_Human	1.85758822
16	FUS_26573619_Chip-Seq_HEK293_Human	1.84452906
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.83702910
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.79737681
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.74300732
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.73179261
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72577356
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.72162828
23	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69720005
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.69720005
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69348697
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69319501
27	STAT3_23295773_ChIP-Seq_U87_Human	1.68538940
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60775523
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.59488327
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58767964
31	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57646719
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56618813
33	TCF4_23295773_ChIP-Seq_U87_Human	1.55428807
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54339882
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52346133
36	DROSHA_22980978_ChIP-Seq_HELA_Human	1.51633585
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.50600209
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.50069692
39	AR_25329375_ChIP-Seq_VCAP_Human	1.49815105
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.49267145
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47519420
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.47271410
43	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.42316648
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41772533
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40292845
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39170189
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36084899
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.34766471
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34478382
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34017505
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32968545
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.32959109
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32959109
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.31408934
55	GATA1_22025678_ChIP-Seq_K562_Human	1.28830901
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28643188
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24930577
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24393261
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.24061865
60	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.22404183
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21862410
62	TP53_16413492_ChIP-PET_HCT116_Human	1.20722650
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19029587
64	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.18797036
65	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.18319946
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18109323
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.17528525
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16838077
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16581073
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16581073
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16534776
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15452097
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14837708
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14666391
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14666391
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13884213
77	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13426415
78	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12845850
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10397418
80	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.10071230
81	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10049694
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08932682
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08419965
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07719770
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06791063
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05932650
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05371368
88	KDM2B_26808549_Chip-Seq_REH_Human	1.05133839
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04546211
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04118032
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04077255
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03835861
93	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.03602625
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03372778
95	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02870146
96	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.01745266
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01726943
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01708908
99	NCOR_22424771_ChIP-Seq_293T_Human	1.01498846
100	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00281454

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.49597624
2	MP0003646_muscle_fatigue	3.07993966
3	MP0003195_calcinosis	2.97696913
4	MP0004147_increased_porphyrin_level	2.77179467
5	MP0008877_abnormal_DNA_methylation	2.61519760
6	MP0002735_abnormal_chemical_nociception	2.40834957
7	MP0009046_muscle_twitch	2.34045335
8	MP0004043_abnormal_pH_regulation	2.31093212
9	MP0005551_abnormal_eye_electrophysiolog	2.29529506
10	MP0002102_abnormal_ear_morphology	2.26179562
11	MP0009745_abnormal_behavioral_response	2.24561704
12	MP0001968_abnormal_touch/_nociception	2.15470931
13	MP0008872_abnormal_physiological_respon	2.13775211
14	MP0004885_abnormal_endolymph	2.11968039
15	MP0004142_abnormal_muscle_tone	2.01571293
16	MP0003787_abnormal_imprinting	1.91543172
17	MP0005645_abnormal_hypothalamus_physiol	1.88026623
18	MP0002272_abnormal_nervous_system	1.87487728
19	MP0001501_abnormal_sleep_pattern	1.87225004
20	MP0002837_dystrophic_cardiac_calcinosis	1.84621209
21	MP0001486_abnormal_startle_reflex	1.82868357
22	MP0003136_yellow_coat_color	1.82574731
23	MP0001485_abnormal_pinna_reflex	1.78583603
24	MP0005167_abnormal_blood-brain_barrier	1.78452926
25	MP0002638_abnormal_pupillary_reflex	1.75605077
26	MP0003880_abnormal_central_pattern	1.75481477
27	MP0002064_seizures	1.69630353
28	MP0004742_abnormal_vestibular_system	1.64774976
29	MP0000427_abnormal_hair_cycle	1.60478912
30	MP0001986_abnormal_taste_sensitivity	1.55268817
31	MP0004133_heterotaxia	1.54383109
32	MP0001970_abnormal_pain_threshold	1.53921537
33	MP0006276_abnormal_autonomic_nervous	1.52935505
34	MP0002876_abnormal_thyroid_physiology	1.52575956
35	MP0005386_behavior/neurological_phenoty	1.51911379
36	MP0004924_abnormal_behavior	1.51911379
37	MP0002736_abnormal_nociception_after	1.51239428
38	MP0002572_abnormal_emotion/affect_behav	1.51224170
39	MP0005174_abnormal_tail_pigmentation	1.49865659
40	MP0002733_abnormal_thermal_nociception	1.49640010
41	MP0005253_abnormal_eye_physiology	1.48195009
42	MP0003635_abnormal_synaptic_transmissio	1.48142302
43	MP0002067_abnormal_sensory_capabilities	1.46780755
44	MP0002653_abnormal_ependyma_morphology	1.45515922
45	MP0002063_abnormal_learning/memory/cond	1.41589795
46	MP0006292_abnormal_olfactory_placode	1.39707285
47	MP0005646_abnormal_pituitary_gland	1.38235498
48	MP0004130_abnormal_muscle_cell	1.37329455
49	MP0003890_abnormal_embryonic-extraembry	1.37002219
50	MP0002557_abnormal_social/conspecific_i	1.35385145
51	MP0002734_abnormal_mechanical_nocicepti	1.31105863
52	MP0000631_abnormal_neuroendocrine_gland	1.24788674
53	MP0008875_abnormal_xenobiotic_pharmacok	1.24461446
54	MP0000778_abnormal_nervous_system	1.22684191
55	MP0002928_abnormal_bile_duct	1.17757803
56	MP0001984_abnormal_olfaction	1.17233722
57	MP0004145_abnormal_muscle_electrophysio	1.15020356
58	MP0006072_abnormal_retinal_apoptosis	1.13696343
59	MP0000230_abnormal_systemic_arterial	1.11294587
60	MP0010386_abnormal_urinary_bladder	1.10905868
61	MP0003137_abnormal_impulse_conducting	1.10325548
62	MP0000383_abnormal_hair_follicle	1.10288463
63	MP0002938_white_spotting	1.06357287
64	MP0005195_abnormal_posterior_eye	1.01047219
65	MP0003878_abnormal_ear_physiology	1.00612720
66	MP0005377_hearing/vestibular/ear_phenot	1.00612720
67	MP0001440_abnormal_grooming_behavior	0.95995757
68	MP0002095_abnormal_skin_pigmentation	0.95688584
69	MP0005423_abnormal_somatic_nervous	0.94858907
70	MP0003011_delayed_dark_adaptation	0.90858367
71	MP0005448_abnormal_energy_balance	0.89587922
72	MP0001529_abnormal_vocalization	0.88203438
73	MP0002160_abnormal_reproductive_system	0.87940879
74	MP0000372_irregular_coat_pigmentation	0.87771274
75	MP0005389_reproductive_system_phenotype	0.87056482
76	MP0003119_abnormal_digestive_system	0.86611151
77	MP0002229_neurodegeneration	0.85442660
78	MP0008995_early_reproductive_senescence	0.85105060
79	MP0002752_abnormal_somatic_nervous	0.84719808
80	MP0000026_abnormal_inner_ear	0.82785441
81	MP0003283_abnormal_digestive_organ	0.82710438
82	MP0001502_abnormal_circadian_rhythm	0.82290750
83	MP0008961_abnormal_basal_metabolism	0.80078014
84	MP0002822_catalepsy	0.79877506
85	MP0002184_abnormal_innervation	0.78777915
86	MP0004215_abnormal_myocardial_fiber	0.78693374
87	MP0002882_abnormal_neuron_morphology	0.78405320
88	MP0005084_abnormal_gallbladder_morpholo	0.78362107
89	MP0001963_abnormal_hearing_physiology	0.77847152
90	MP0005410_abnormal_fertilization	0.77371307
91	MP0003633_abnormal_nervous_system	0.77058665
92	MP0001905_abnormal_dopamine_level	0.77053029
93	MP0005085_abnormal_gallbladder_physiolo	0.76965664
94	MP0003718_maternal_effect	0.76301349
95	MP0002277_abnormal_respiratory_mucosa	0.76154966
96	MP0002751_abnormal_autonomic_nervous	0.73687552
97	MP0001324_abnormal_eye_pigmentation	0.73227271
98	MP0003698_abnormal_male_reproductive	0.72637282
99	MP0000538_abnormal_urinary_bladder	0.72165029
100	MP0003252_abnormal_bile_duct	0.71834590

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	5.30510781
2	Pancreatic cysts (HP:0001737)	4.67991364
3	Hyperventilation (HP:0002883)	4.34367525
4	Abnormality of midbrain morphology (HP:0002418)	4.27594950
5	Molar tooth sign on MRI (HP:0002419)	4.27594950
6	Pancreatic fibrosis (HP:0100732)	4.15230342
7	True hermaphroditism (HP:0010459)	3.96501404
8	Congenital stationary night blindness (HP:0007642)	3.94229305
9	Nephronophthisis (HP:0000090)	3.79647488
10	Genetic anticipation (HP:0003743)	3.58797606
11	Type II lissencephaly (HP:0007260)	3.43362502
12	Abnormality of the renal medulla (HP:0100957)	3.37640521
13	Inability to walk (HP:0002540)	3.29695614
14	Protruding tongue (HP:0010808)	3.26820454
15	Chronic hepatic failure (HP:0100626)	3.18903520
16	Abnormality of the renal cortex (HP:0011035)	3.18898907
17	Progressive cerebellar ataxia (HP:0002073)	3.18413017
18	Patellar aplasia (HP:0006443)	3.13325699
19	Breast hypoplasia (HP:0003187)	3.06341397
20	Cystic liver disease (HP:0006706)	2.92796858
21	Aplasia/Hypoplasia of the patella (HP:0006498)	2.92033001
22	Attenuation of retinal blood vessels (HP:0007843)	2.91979439
23	Broad-based gait (HP:0002136)	2.83973072
24	Medial flaring of the eyebrow (HP:0010747)	2.83903461
25	Large for gestational age (HP:0001520)	2.83719934
26	Clumsiness (HP:0002312)	2.78854248
27	Progressive inability to walk (HP:0002505)	2.69615782
28	Lissencephaly (HP:0001339)	2.69578364
29	Gaze-evoked nystagmus (HP:0000640)	2.69091639
30	Abnormality of alanine metabolism (HP:0010916)	2.69027226
31	Hyperalaninemia (HP:0003348)	2.69027226
32	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.69027226
33	Tubular atrophy (HP:0000092)	2.61461809
34	Pendular nystagmus (HP:0012043)	2.54468472
35	Gait imbalance (HP:0002141)	2.49670805
36	Abolished electroretinogram (ERG) (HP:0000550)	2.48689830
37	Furrowed tongue (HP:0000221)	2.44940754
38	Chorioretinal atrophy (HP:0000533)	2.38833195
39	Stomach cancer (HP:0012126)	2.37197551
40	Congenital primary aphakia (HP:0007707)	2.34813725
41	Abnormal drinking behavior (HP:0030082)	2.32561307
42	Polydipsia (HP:0001959)	2.32561307
43	Increased corneal curvature (HP:0100692)	2.30743013
44	Keratoconus (HP:0000563)	2.30743013
45	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.29941003
46	Fair hair (HP:0002286)	2.28495334
47	Febrile seizures (HP:0002373)	2.26595431
48	Absent/shortened dynein arms (HP:0200106)	2.25912123
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.25912123
50	Decreased circulating renin level (HP:0003351)	2.24247992
51	Absent speech (HP:0001344)	2.21248325
52	Anencephaly (HP:0002323)	2.21148639
53	Sclerocornea (HP:0000647)	2.18206733
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.17700185
55	Widely spaced teeth (HP:0000687)	2.16609009
56	Congenital, generalized hypertrichosis (HP:0004540)	2.15406016
57	Cerebellar dysplasia (HP:0007033)	2.14305758
58	Concave nail (HP:0001598)	2.14213791
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.14213283
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.14213283
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12128600
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.11077702
63	Nephrogenic diabetes insipidus (HP:0009806)	2.10174500
64	Hemiparesis (HP:0001269)	2.07784349
65	Abnormality of the pons (HP:0007361)	2.07723065
66	Congenital hepatic fibrosis (HP:0002612)	2.07307196
67	Congenital sensorineural hearing impairment (HP:0008527)	2.04439038
68	Microretrognathia (HP:0000308)	2.02252520
69	Decreased central vision (HP:0007663)	2.01708858
70	Genital tract atresia (HP:0001827)	2.00198977
71	Male pseudohermaphroditism (HP:0000037)	1.95469008
72	Abnormal ciliary motility (HP:0012262)	1.94220517
73	Hypoplasia of the pons (HP:0012110)	1.93220688
74	Vaginal atresia (HP:0000148)	1.93002359
75	Drooling (HP:0002307)	1.92481480
76	Polyuria (HP:0000103)	1.91037901
77	Retinal dysplasia (HP:0007973)	1.90683562
78	Pachygyria (HP:0001302)	1.90538426
79	Abnormal biliary tract physiology (HP:0012439)	1.89349996
80	Bile duct proliferation (HP:0001408)	1.89349996
81	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.89144779
82	Poor coordination (HP:0002370)	1.87974324
83	Renal cortical cysts (HP:0000803)	1.86713811
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.85874530
85	Generalized hypopigmentation of hair (HP:0011358)	1.85474809
86	Focal seizures (HP:0007359)	1.81200254
87	Partial agenesis of the corpus callosum (HP:0001338)	1.80408432
88	Focal motor seizures (HP:0011153)	1.78200936
89	Excessive salivation (HP:0003781)	1.77393826
90	Bulbous nose (HP:0000414)	1.76888626
91	Optic nerve hypoplasia (HP:0000609)	1.76787275
92	Bony spicule pigmentary retinopathy (HP:0007737)	1.75686101
93	Scrotal hypoplasia (HP:0000046)	1.73344117
94	Dyskinesia (HP:0100660)	1.72686935
95	Severe muscular hypotonia (HP:0006829)	1.70486984
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.68690131
97	Postaxial foot polydactyly (HP:0001830)	1.67818068
98	Abnormality of the renal collecting system (HP:0004742)	1.67204612
99	Dandy-Walker malformation (HP:0001305)	1.65959408
100	Hypoplastic labia majora (HP:0000059)	1.64694965

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.62166195
2	ACVR1B	4.93140308
3	BMPR1B	4.19874096
4	ADRBK2	3.18390633
5	CASK	3.03530793
6	TLK1	2.53016763
7	DAPK2	2.50810698
8	ZAK	2.25005089
9	INSRR	2.21601054
10	TAOK3	2.07772401
11	TGFBR1	2.02349435
12	GRK1	1.96392569
13	WNK3	1.95494618
14	CAMKK2	1.91176979
15	MAPK13	1.88754958
16	WNK4	1.76191649
17	PINK1	1.68488010
18	MAP3K4	1.63283704
19	MAP4K2	1.55615238
20	CAMKK1	1.50692075
21	MARK1	1.47308144
22	SIK2	1.47185048
23	ADRBK1	1.42472254
24	TXK	1.34936091
25	NUAK1	1.34846069
26	PNCK	1.26895137
27	NTRK2	1.24145717
28	MKNK2	1.22824035
29	NTRK3	1.19061122
30	CAMK1D	1.14965478
31	TNIK	1.13822215
32	OXSR1	1.08436845
33	PTK2B	1.01994087
34	PAK3	0.97410222
35	MAPK15	0.92612728
36	MAP2K7	0.88041413
37	MAP2K6	0.87791843
38	CAMK1G	0.86059301
39	STK38L	0.85603266
40	NEK2	0.83125116
41	PRKCG	0.79165561
42	PIK3CA	0.78715110
43	CAMK1	0.78709184
44	TIE1	0.75722119
45	SGK2	0.75180821
46	DYRK2	0.73714511
47	AKT3	0.71007511
48	PRKCE	0.69218155
49	CAMK2A	0.66479852
50	TEC	0.66025954
51	STK39	0.65893787
52	PKN1	0.64997749
53	CAMK4	0.62872388
54	MAP3K7	0.61241847
55	IKBKB	0.59717823
56	CHUK	0.59563397
57	STK11	0.59436363
58	PRKCQ	0.58750969
59	MAP2K1	0.56505918
60	SGK223	0.55582724
61	SGK494	0.55582724
62	WNK1	0.54905184
63	RPS6KA5	0.53558060
64	EPHA3	0.50191921
65	SYK	0.49684152
66	RPS6KA6	0.48536157
67	MELK	0.47849605
68	TYRO3	0.46632482
69	MAP2K4	0.44985524
70	PRKCZ	0.44590053
71	PIK3CG	0.44245973
72	PRKAA2	0.44146924
73	NME1	0.44052553
74	OBSCN	0.44026039
75	NLK	0.43535056
76	ITK	0.43482977
77	TNK2	0.42128683
78	PRKACA	0.40463442
79	PRKCH	0.39950703
80	FGFR2	0.38819683
81	KIT	0.38593457
82	MAP4K1	0.38062663
83	IRAK1	0.37540821
84	BRSK2	0.36705295
85	MKNK1	0.35668529
86	MAPKAPK3	0.35125793
87	PRKAA1	0.34894095
88	MAPKAPK5	0.34120123
89	PHKG1	0.33641559
90	PHKG2	0.33641559
91	GRK7	0.33402090
92	IKBKE	0.32717469
93	DYRK1A	0.32438406
94	TRPM7	0.31904125
95	SGK1	0.31296178
96	CSNK1G2	0.30871558
97	PLK2	0.30728747
98	CSNK1D	0.29931285
99	MUSK	0.29924461
100	CSNK1A1	0.28635212

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.97109161
2	Nicotine addiction_Homo sapiens_hsa05033	2.89331143
3	Phototransduction_Homo sapiens_hsa04744	2.89253778
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.84448480
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.62931546
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.59537546
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.34037836
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26710265
9	Butanoate metabolism_Homo sapiens_hsa00650	2.25300121
10	ABC transporters_Homo sapiens_hsa02010	2.01506390
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00254604
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.99445680
13	Ether lipid metabolism_Homo sapiens_hsa00565	1.95884378
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.86698012
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.80499554
16	Morphine addiction_Homo sapiens_hsa05032	1.74705403
17	Taste transduction_Homo sapiens_hsa04742	1.72716108
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72586336
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.69982510
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.49087647
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.48377006
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.48014276
23	Olfactory transduction_Homo sapiens_hsa04740	1.44182569
24	Circadian entrainment_Homo sapiens_hsa04713	1.43598162
25	GABAergic synapse_Homo sapiens_hsa04727	1.42545094
26	Caffeine metabolism_Homo sapiens_hsa00232	1.42161022
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.39723834
28	Serotonergic synapse_Homo sapiens_hsa04726	1.39444962
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.39192833
30	Insulin secretion_Homo sapiens_hsa04911	1.33551472
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.30505379
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20998107
33	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.19304495
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.13908886
35	Homologous recombination_Homo sapiens_hsa03440	1.09724805
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03508656
37	Long-term depression_Homo sapiens_hsa04730	1.03507783
38	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03373374
39	Basal transcription factors_Homo sapiens_hsa03022	1.03200820
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02957819
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.99199999
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97546080
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95110475
44	Salivary secretion_Homo sapiens_hsa04970	0.91669379
45	Oxidative phosphorylation_Homo sapiens_hsa00190	0.90513679
46	Histidine metabolism_Homo sapiens_hsa00340	0.90403024
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88956202
48	Cocaine addiction_Homo sapiens_hsa05030	0.88010141
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.85438701
50	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.84978558
51	Cholinergic synapse_Homo sapiens_hsa04725	0.82334363
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79733564
53	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.79108429
54	Asthma_Homo sapiens_hsa05310	0.77754731
55	Peroxisome_Homo sapiens_hsa04146	0.74531819
56	Retinol metabolism_Homo sapiens_hsa00830	0.72454795
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71987190
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71902855
59	Regulation of autophagy_Homo sapiens_hsa04140	0.71609018
60	Amphetamine addiction_Homo sapiens_hsa05031	0.70585581
61	Graft-versus-host disease_Homo sapiens_hsa05332	0.70523799
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70274341
63	Gastric acid secretion_Homo sapiens_hsa04971	0.69582630
64	Primary immunodeficiency_Homo sapiens_hsa05340	0.69541519
65	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.69488677
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67129915
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.66949249
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.66917187
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65174357
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63765528
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.63715944
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61688931
73	RNA degradation_Homo sapiens_hsa03018	0.61414425
74	Circadian rhythm_Homo sapiens_hsa04710	0.60559178
75	RNA polymerase_Homo sapiens_hsa03020	0.60405231
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.59430632
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58752343
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58390848
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58327599
80	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56751306
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.54943853
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.50971055
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.50031303
84	Parkinsons disease_Homo sapiens_hsa05012	0.48862435
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47929689
86	Propanoate metabolism_Homo sapiens_hsa00640	0.47297321
87	Mineral absorption_Homo sapiens_hsa04978	0.46995975
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45002302
89	Allograft rejection_Homo sapiens_hsa05330	0.43113123
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.42994400
91	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.40391832
92	Pancreatic secretion_Homo sapiens_hsa04972	0.39606670
93	Axon guidance_Homo sapiens_hsa04360	0.39458793
94	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38947940
95	Protein export_Homo sapiens_hsa03060	0.38557715
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38539581
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37632932
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.36178967
99	MAPK signaling pathway_Homo sapiens_hsa04010	0.35574381
100	Alzheimers disease_Homo sapiens_hsa05010	0.34453124

ZNF506

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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