ZNF507

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.99579410
2nuclear pore organization (GO:0006999)6.26017039
3mitotic sister chromatid cohesion (GO:0007064)6.09361262
4pore complex assembly (GO:0046931)4.90934229
5pre-miRNA processing (GO:0031054)4.79955458
6regulation of RNA export from nucleus (GO:0046831)4.48386617
7sister chromatid segregation (GO:0000819)4.13407507
8monoubiquitinated protein deubiquitination (GO:0035520)4.10180561
9mitotic sister chromatid segregation (GO:0000070)3.94446652
10mitotic chromosome condensation (GO:0007076)3.93853539
11cytoplasmic mRNA processing body assembly (GO:0033962)3.87867031
12DNA unwinding involved in DNA replication (GO:0006268)3.85495363
13negative regulation of DNA repair (GO:0045738)3.69489571
14protein localization to chromosome, centromeric region (GO:0071459)3.60884306
15regulation of nucleobase-containing compound transport (GO:0032239)3.60746063
16protein localization to kinetochore (GO:0034501)3.58143657
17regulation of DNA damage checkpoint (GO:2000001)3.56916211
18negative regulation of histone methylation (GO:0031061)3.55756466
19negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.55383038
20regulation of DNA endoreduplication (GO:0032875)3.53264475
21sister chromatid cohesion (GO:0007062)3.51151314
22positive regulation of mitotic sister chromatid separation (GO:1901970)3.50997076
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50997076
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50997076
25negative regulation of cell cycle G2/M phase transition (GO:1902750)3.44745646
26DNA duplex unwinding (GO:0032508)3.35287691
27DNA geometric change (GO:0032392)3.29320783
28mitotic nuclear envelope disassembly (GO:0007077)3.28517519
29membrane disassembly (GO:0030397)3.27550781
30nuclear envelope disassembly (GO:0051081)3.27550781
31glucocorticoid receptor signaling pathway (GO:0042921)3.12834643
32non-recombinational repair (GO:0000726)3.10319586
33double-strand break repair via nonhomologous end joining (GO:0006303)3.10319586
34positive regulation of chromosome segregation (GO:0051984)3.09545022
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06928279
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.06928279
37regulation of translation, ncRNA-mediated (GO:0045974)3.06928279
38regulation of histone H3-K27 methylation (GO:0061085)2.99171700
39interkinetic nuclear migration (GO:0022027)2.99026662
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95705429
41DNA replication checkpoint (GO:0000076)2.93683660
42histone H3-K4 trimethylation (GO:0080182)2.92121024
43regulation of centriole replication (GO:0046599)2.91904960
44heterochromatin organization (GO:0070828)2.90959143
45NLS-bearing protein import into nucleus (GO:0006607)2.86868902
46positive regulation of cell cycle checkpoint (GO:1901978)2.85080467
47DNA conformation change (GO:0071103)2.83844950
48nuclear envelope organization (GO:0006998)2.81080779
49dosage compensation (GO:0007549)2.80853634
50V(D)J recombination (GO:0033151)2.80674131
51ribosome assembly (GO:0042255)2.80520484
52regulation of histone methylation (GO:0031060)2.80376805
53DNA topological change (GO:0006265)2.77895145
54positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.77622138
55peptidyl-lysine trimethylation (GO:0018023)2.76885682
56regulation of NFAT protein import into nucleus (GO:0051532)2.74477879
57regulation of sister chromatid cohesion (GO:0007063)2.74470076
58regulation of histone H3-K4 methylation (GO:0051569)2.74210931
59histone H4-K16 acetylation (GO:0043984)2.73618159
60regulation of mitotic spindle organization (GO:0060236)2.73407673
61regulation of sister chromatid segregation (GO:0033045)2.71271146
62regulation of mitotic sister chromatid separation (GO:0010965)2.71271146
63regulation of mitotic sister chromatid segregation (GO:0033047)2.71271146
64histone H3-K4 methylation (GO:0051568)2.71127750
65mitotic metaphase plate congression (GO:0007080)2.70552756
66negative regulation of mRNA processing (GO:0050686)2.70188818
67phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.69907910
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68786018
69regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68786018
70meiotic chromosome segregation (GO:0045132)2.67434119
71DNA synthesis involved in DNA repair (GO:0000731)2.66643534
72spindle checkpoint (GO:0031577)2.66520866
73attachment of spindle microtubules to kinetochore (GO:0008608)2.65957265
74nucleus organization (GO:0006997)2.65476957
75regulation of histone H3-K9 methylation (GO:0051570)2.65216950
76histone H3-K36 demethylation (GO:0070544)2.64638138
77microtubule anchoring (GO:0034453)2.63968747
78regulation of chromosome segregation (GO:0051983)2.63786789
79negative regulation of mRNA metabolic process (GO:1903312)2.63690457
80N-terminal protein amino acid acetylation (GO:0006474)2.63648162
81regulation of pigment cell differentiation (GO:0050932)2.63620528
82DNA replication initiation (GO:0006270)2.63383002
83peptidyl-lysine methylation (GO:0018022)2.63144190
84mRNA transport (GO:0051028)2.62987263
85protein localization to chromosome (GO:0034502)2.62567963
86regulation of spindle organization (GO:0090224)2.61161385
87RNA stabilization (GO:0043489)2.61007679
88mRNA stabilization (GO:0048255)2.61007679
89histone-serine phosphorylation (GO:0035404)2.60495299
90histone lysine methylation (GO:0034968)2.59329749
91negative regulation of chromosome segregation (GO:0051985)2.57581408
92nucleus localization (GO:0051647)2.57478100
93corticosteroid receptor signaling pathway (GO:0031958)2.54268725
94regulation of centrosome duplication (GO:0010824)2.54146113
95kinetochore organization (GO:0051383)2.52972093
96establishment of nucleus localization (GO:0040023)2.51832177
97positive regulation of macroautophagy (GO:0016239)2.50440478
98peptidyl-lysine dimethylation (GO:0018027)2.50294668
99mitotic spindle checkpoint (GO:0071174)2.49851129
100regulation of cell cycle checkpoint (GO:1901976)2.48790760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.62904128
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.03833411
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10403006
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.91991897
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.83545235
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78322124
7AR_21909140_ChIP-Seq_LNCAP_Human2.74454310
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63975360
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.58722877
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55046101
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.26117048
12YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22660810
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15817389
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14991860
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.10978507
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06109913
17FUS_26573619_Chip-Seq_HEK293_Human2.02539285
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99733491
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.97807894
20EWS_26573619_Chip-Seq_HEK293_Human1.95613751
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95496851
22* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.87750234
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.84797407
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.82965811
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.77018241
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.73265004
27PKCTHETA_26484144_Chip-Seq_BREAST_Human1.68254921
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64377322
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58042354
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54548513
31CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54037112
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52785427
33* CHD1_26751641_Chip-Seq_LNCaP_Human1.52304241
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50508617
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48919425
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48258249
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45672550
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43573911
39ELK1_19687146_ChIP-ChIP_HELA_Human1.42459526
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39490239
41MYC_22102868_ChIP-Seq_BL_Human1.38503668
42* CIITA_25753668_ChIP-Seq_RAJI_Human1.38083637
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33679011
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.26995260
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21436553
46KDM5A_27292631_Chip-Seq_BREAST_Human1.20239830
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20140670
48SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20124192
49* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13153552
50* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12791921
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12045992
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11607455
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11464589
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10960931
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10374649
56TAF15_26573619_Chip-Seq_HEK293_Human1.09914996
57TTF2_22483619_ChIP-Seq_HELA_Human1.09651836
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07849985
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07601480
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07324822
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07038001
62AR_21572438_ChIP-Seq_LNCaP_Human1.04000312
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02348304
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01722670
65SOX9_26525672_Chip-Seq_HEART_Mouse1.00882880
66FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00651014
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99932150
68* STAT3_23295773_ChIP-Seq_U87_Human0.99152661
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98335677
70CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97952829
71NANOG_21062744_ChIP-ChIP_HESCs_Human0.97897043
72DCP1A_22483619_ChIP-Seq_HELA_Human0.97765910
73PIAS1_25552417_ChIP-Seq_VCAP_Human0.96616380
74TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96546717
75FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95553939
76TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95316128
77YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93802361
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91838532
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91064693
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90866230
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90293702
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89686002
83GF1B_26923725_Chip-Seq_HPCs_Mouse0.88393460
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87076028
85XRN2_22483619_ChIP-Seq_HELA_Human0.87025303
86NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86542087
87* FOXO3_23340844_ChIP-Seq_DLD1_Human0.84726114
88ISL1_27105846_Chip-Seq_CPCs_Mouse0.84472585
89TP53_16413492_ChIP-PET_HCT116_Human0.83769457
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82973968
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82588509
92GATA1_22025678_ChIP-Seq_K562_Human0.79584106
93VDR_23849224_ChIP-Seq_CD4+_Human0.79540990
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.79445898
95BRD4_25478319_ChIP-Seq_HGPS_Human0.78987295
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78889960
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.77518878
98* TFEB_21752829_ChIP-Seq_HELA_Human0.77252848
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76753382
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75724327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.36471765
2MP0010094_abnormal_chromosome_stability3.27066466
3MP0002009_preneoplasia3.24654284
4MP0003111_abnormal_nucleus_morphology3.03569730
5MP0003077_abnormal_cell_cycle2.67443849
6MP0010352_gastrointestinal_tract_polyps2.37367178
7MP0004957_abnormal_blastocyst_morpholog2.36341744
8MP0008058_abnormal_DNA_repair2.24573255
9MP0003890_abnormal_embryonic-extraembry2.23163980
10MP0003693_abnormal_embryo_hatching2.14352952
11MP0002396_abnormal_hematopoietic_system2.07025646
12MP0001730_embryonic_growth_arrest1.91204848
13MP0005187_abnormal_penis_morphology1.87255254
14MP0005076_abnormal_cell_differentiation1.83019827
15MP0009697_abnormal_copulation1.78723059
16MP0000350_abnormal_cell_proliferation1.77185564
17MP0001672_abnormal_embryogenesis/_devel1.74668974
18MP0005380_embryogenesis_phenotype1.74668974
19MP0003984_embryonic_growth_retardation1.74071373
20MP0005409_darkened_coat_color1.71459029
21MP0002084_abnormal_developmental_patter1.70710847
22MP0001188_hyperpigmentation1.69190358
23MP0002088_abnormal_embryonic_growth/wei1.68942853
24MP0008007_abnormal_cellular_replicative1.64837380
25MP0010307_abnormal_tumor_latency1.60879533
26MP0001697_abnormal_embryo_size1.58291483
27MP0008932_abnormal_embryonic_tissue1.57380416
28MP0003937_abnormal_limbs/digits/tail_de1.57118810
29MP0004197_abnormal_fetal_growth/weight/1.54371136
30MP0000566_synostosis1.51648698
31MP0002085_abnormal_embryonic_tissue1.47149223
32MP0009672_abnormal_birth_weight1.43142546
33MP0002086_abnormal_extraembryonic_tissu1.42692577
34MP0009703_decreased_birth_body1.42538103
35MP0004185_abnormal_adipocyte_glucose1.39694940
36MP0000537_abnormal_urethra_morphology1.39660163
37MP0000569_abnormal_digit_pigmentation1.38926477
38MP0000428_abnormal_craniofacial_morphol1.36714412
39MP0005623_abnormal_meninges_morphology1.35938976
40MP0004808_abnormal_hematopoietic_stem1.35897769
41MP0002080_prenatal_lethality1.27253305
42MP0001346_abnormal_lacrimal_gland1.26634650
43MP0003941_abnormal_skin_development1.23830455
44MP0002697_abnormal_eye_size1.23117701
45MP0003935_abnormal_craniofacial_develop1.21301397
46MP0002249_abnormal_larynx_morphology1.16474426
47MP0003943_abnormal_hepatobiliary_system1.16447715
48MP0001286_abnormal_eye_development1.16386983
49MP0000383_abnormal_hair_follicle1.16302674
50MP0010678_abnormal_skin_adnexa1.10626376
51MP0004233_abnormal_muscle_weight1.08510334
52MP0001293_anophthalmia1.07723911
53MP0003567_abnormal_fetal_cardiomyocyte1.07327926
54MP0000733_abnormal_muscle_development1.04670903
55MP0003385_abnormal_body_wall1.04458939
56MP0000003_abnormal_adipose_tissue1.03470440
57MP0008961_abnormal_basal_metabolism1.02956569
58MP0000432_abnormal_head_morphology1.02842923
59MP0003221_abnormal_cardiomyocyte_apopto1.01916067
60MP0001299_abnormal_eye_distance/0.98686814
61MP0002092_abnormal_eye_morphology0.98554049
62MP0003861_abnormal_nervous_system0.97942041
63MP0001661_extended_life_span0.95024427
64MP0008877_abnormal_DNA_methylation0.94912938
65MP0003115_abnormal_respiratory_system0.94383699
66MP0002166_altered_tumor_susceptibility0.93833605
67MP0002160_abnormal_reproductive_system0.93323577
68MP0003942_abnormal_urinary_system0.92575282
69MP0003755_abnormal_palate_morphology0.90659909
70MP0002114_abnormal_axial_skeleton0.90429649
71MP0004134_abnormal_chest_morphology0.90138170
72MP0003786_premature_aging0.89450586
73MP0002081_perinatal_lethality0.87070654
74MP0002108_abnormal_muscle_morphology0.86570873
75MP0000313_abnormal_cell_death0.83328058
76MP0002938_white_spotting0.83213304
77MP0002925_abnormal_cardiovascular_devel0.82500562
78MP0002233_abnormal_nose_morphology0.82338527
79MP0010630_abnormal_cardiac_muscle0.82268587
80MP0003718_maternal_effect0.82234306
81MP0004264_abnormal_extraembryonic_tissu0.78530111
82MP0005174_abnormal_tail_pigmentation0.77391043
83MP0005621_abnormal_cell_physiology0.76782484
84MP0000516_abnormal_urinary_system0.76777131
85MP0005367_renal/urinary_system_phenotyp0.76777131
86MP0006292_abnormal_olfactory_placode0.75308490
87MP0001915_intracranial_hemorrhage0.74439078
88MP0002177_abnormal_outer_ear0.74311819
89MP0000534_abnormal_ureter_morphology0.73662290
90MP0003119_abnormal_digestive_system0.72313781
91MP0002111_abnormal_tail_morphology0.72216932
92MP0001340_abnormal_eyelid_morphology0.71164835
93MP0009250_abnormal_appendicular_skeleto0.70985188
94MP0000266_abnormal_heart_morphology0.68723792
95MP0003763_abnormal_thymus_physiology0.68233595
96MP0010030_abnormal_orbit_morphology0.67463725
97MP0002210_abnormal_sex_determination0.67336814
98MP0002116_abnormal_craniofacial_bone0.66530544
99MP0000703_abnormal_thymus_morphology0.64804919
100MP0001145_abnormal_male_reproductive0.63940271

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.70556479
2Papillary thyroid carcinoma (HP:0002895)3.42950903
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40842126
4Volvulus (HP:0002580)3.05940356
5Hepatoblastoma (HP:0002884)3.02616019
6Abnormality of the fingertips (HP:0001211)2.91138993
7Medulloblastoma (HP:0002885)2.82487335
8Nephroblastoma (Wilms tumor) (HP:0002667)2.77349597
9Facial hemangioma (HP:0000329)2.75480057
10Birth length less than 3rd percentile (HP:0003561)2.65991109
11Septate vagina (HP:0001153)2.64585355
12Abnormality of chromosome stability (HP:0003220)2.64062496
13Embryonal renal neoplasm (HP:0011794)2.59743238
14Acute myeloid leukemia (HP:0004808)2.58814569
15Neonatal hypoglycemia (HP:0001998)2.54898820
16Long eyelashes (HP:0000527)2.48573185
17Heterotopia (HP:0002282)2.40678473
18Truncal obesity (HP:0001956)2.39112489
19High anterior hairline (HP:0009890)2.38513945
20Astrocytoma (HP:0009592)2.34134787
21Abnormality of the astrocytes (HP:0100707)2.34134787
22Dysmetric saccades (HP:0000641)2.31039796
23Rhabdomyosarcoma (HP:0002859)2.29691416
24Aplasia/Hypoplasia of the sternum (HP:0006714)2.28577180
25Neoplasm of the adrenal cortex (HP:0100641)2.26381636
26Narrow palate (HP:0000189)2.25786509
27Hypoplastic labia majora (HP:0000059)2.25404768
28Prominent nose (HP:0000448)2.25089427
29Ectopic kidney (HP:0000086)2.24532822
30Abnormality of chromosome segregation (HP:0002916)2.21765236
31Abnormality of the labia majora (HP:0012881)2.21316563
32Deep philtrum (HP:0002002)2.21036809
33Sandal gap (HP:0001852)2.20455657
34Anal stenosis (HP:0002025)2.18859796
35Cafe-au-lait spot (HP:0000957)2.16831449
36Increased nuchal translucency (HP:0010880)2.15894083
37Low anterior hairline (HP:0000294)2.11200338
38Neoplasm of striated muscle (HP:0009728)2.11046014
39Abnormality of the phalanges of the hallux (HP:0010057)2.10040798
40Overlapping toe (HP:0001845)2.09194082
41Glioma (HP:0009733)2.07992767
42Abnormality of the distal phalanx of the thumb (HP:0009617)2.07815016
43Urethral obstruction (HP:0000796)2.07253462
44Abnormality of the nasal septum (HP:0000419)2.06380763
45Midline defect of the nose (HP:0004122)2.04512356
46Long clavicles (HP:0000890)2.03497436
47Cubitus valgus (HP:0002967)2.03419942
48Thyroid carcinoma (HP:0002890)2.00027873
49Obsessive-compulsive behavior (HP:0000722)1.98552295
50Lip pit (HP:0100267)1.97658069
51Abnormal pancreas size (HP:0012094)1.96752757
52Embryonal neoplasm (HP:0002898)1.96255782
53Vertebral arch anomaly (HP:0008438)1.94401202
54Cystic hygroma (HP:0000476)1.93920805
55Abnormality of the labia minora (HP:0012880)1.91425559
56Aplasia/Hypoplasia of the uvula (HP:0010293)1.90566401
57Abnormality of cochlea (HP:0000375)1.88104246
58Ependymoma (HP:0002888)1.88025775
59Gastrointestinal carcinoma (HP:0002672)1.87895297
60Malignant gastrointestinal tract tumors (HP:0006749)1.87895297
61Persistence of primary teeth (HP:0006335)1.86878897
62Capillary hemangiomas (HP:0005306)1.84660710
63Myelodysplasia (HP:0002863)1.83787914
64Colon cancer (HP:0003003)1.82360907
65Absent radius (HP:0003974)1.80365295
66Overgrowth (HP:0001548)1.79140982
67Macroorchidism (HP:0000053)1.78283283
68Proximal placement of thumb (HP:0009623)1.77676636
69Abnormality of the preputium (HP:0100587)1.77615981
70Abnormality of the parietal bone (HP:0002696)1.77425557
71Abnormality of the left ventricular outflow tract (HP:0011103)1.76103138
72Subaortic stenosis (HP:0001682)1.76103138
73Meckel diverticulum (HP:0002245)1.75981529
74Neoplasm of the oral cavity (HP:0100649)1.75720437
75Deviation of the thumb (HP:0009603)1.75532529
76Abnormal hair whorl (HP:0010721)1.75490171
77Subacute progressive viral hepatitis (HP:0006572)1.72417531
78Germ cell neoplasia (HP:0100728)1.72143571
79Curly hair (HP:0002212)1.71930050
80Submucous cleft hard palate (HP:0000176)1.68048846
81Facial cleft (HP:0002006)1.67819749
82Hypoplasia of the maxilla (HP:0000327)1.67722238
83Hypospadias (HP:0000047)1.66448141
84Transitional cell carcinoma of the bladder (HP:0006740)1.65338364
85Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64784875
86Abnormal number of incisors (HP:0011064)1.63917230
87Thick eyebrow (HP:0000574)1.63170430
88Sloping forehead (HP:0000340)1.63090133
89Abnormality of the ileum (HP:0001549)1.62355600
90Absent forearm bone (HP:0003953)1.62104054
91Aplasia involving forearm bones (HP:0009822)1.62104054
92Abnormality of homocysteine metabolism (HP:0010919)1.61157818
93Homocystinuria (HP:0002156)1.61157818
94Small intestinal stenosis (HP:0012848)1.61051337
95Duodenal stenosis (HP:0100867)1.61051337
96Gastroesophageal reflux (HP:0002020)1.60419367
97Smooth philtrum (HP:0000319)1.59775150
98Trigonocephaly (HP:0000243)1.59655747
99Uterine leiomyosarcoma (HP:0002891)1.58975984
100Leiomyosarcoma (HP:0100243)1.58975984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.35546659
2BRD43.77686582
3CDC72.99545285
4MAP3K102.76156411
5LATS12.71769522
6CAMK1G2.65700220
7AKT32.51659058
8MKNK22.45324124
9CAMK1D2.28576672
10SRPK12.25942750
11BRSK22.23032617
12EEF2K2.06545476
13MKNK11.94872830
14ICK1.88136485
15TTK1.75477535
16PNCK1.68380900
17STK38L1.50613407
18PASK1.49669149
19BUB11.45342729
20TNIK1.45289496
21MELK1.40108248
22ATR1.38639082
23WNK11.38208593
24NLK1.36712220
25CHEK11.30115283
26SGK21.28794128
27PLK41.25930305
28MTOR1.22201584
29CDK61.18921559
30WEE11.18086235
31TAF11.17789388
32FGFR21.17277447
33FRK1.15791016
34ATM1.15231407
35TRIB31.13674730
36STK31.13419731
37EIF2AK31.11156768
38CHEK21.08702374
39FGFR31.04402837
40RPS6KB21.04269167
41SMG11.03711043
42FGFR11.00730545
43NEK11.00092297
44SGK30.98839017
45STK40.94482012
46YES10.91465160
47AURKB0.88152571
48CDK70.87217405
49PLK10.87168883
50CDK20.85235426
51BRSK10.84706675
52CDK10.83468892
53SCYL20.82932269
54NUAK10.81562932
55CDK40.79926496
56TSSK60.77213385
57ACVR1B0.76841491
58CDK30.74976499
59EIF2AK10.74479133
60PBK0.73892965
61KSR10.73541573
62PDGFRA0.73411872
63NEK20.72956283
64MAPK110.72945009
65PLK30.72812171
66RAF10.72699757
67SGK2230.70351375
68SGK4940.70351375
69ERBB30.69910393
70DMPK0.69559723
71MAP3K90.67942094
72MAP3K40.66774994
73BMPR1B0.65385873
74KSR20.65003805
75PRKAA10.63796950
76EIF2AK20.63303507
77MAPK100.62716355
78GSK3B0.62645275
79CAMK40.56279332
80NEK90.56206082
81MAPK140.55994558
82MAP3K70.55388826
83PRKDC0.53993167
84PDGFRB0.52552785
85PIM10.52359798
86CSNK1E0.51054649
87RPS6KB10.50891414
88MAP3K20.49923173
89CDK90.48572076
90PRKAA20.48490441
91SGK10.47948707
92STK380.47337525
93TRPM70.47013557
94TRIM280.45667960
95OBSCN0.44856929
96STK390.43598353
97CSNK1D0.39945229
98MAPK80.39541871
99FGFR40.39147545
100AKT10.37689491

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.91776498
2Cell cycle_Homo sapiens_hsa041102.70722944
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47223936
4Lysine degradation_Homo sapiens_hsa003102.35125933
5mRNA surveillance pathway_Homo sapiens_hsa030152.34503482
6DNA replication_Homo sapiens_hsa030302.27726485
7Mismatch repair_Homo sapiens_hsa034302.23596786
8RNA transport_Homo sapiens_hsa030132.17772987
9Fanconi anemia pathway_Homo sapiens_hsa034601.92930956
10Spliceosome_Homo sapiens_hsa030401.81836550
11Adherens junction_Homo sapiens_hsa045201.79532031
12Homologous recombination_Homo sapiens_hsa034401.77326018
13MicroRNAs in cancer_Homo sapiens_hsa052061.75228836
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71381299
15Prostate cancer_Homo sapiens_hsa052151.70167781
16Colorectal cancer_Homo sapiens_hsa052101.69881735
17Thyroid cancer_Homo sapiens_hsa052161.66532833
18Non-small cell lung cancer_Homo sapiens_hsa052231.59985515
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.59926099
20Chronic myeloid leukemia_Homo sapiens_hsa052201.59093353
21Endometrial cancer_Homo sapiens_hsa052131.55867666
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.49743216
23One carbon pool by folate_Homo sapiens_hsa006701.48705689
24RNA degradation_Homo sapiens_hsa030181.42954513
25Basal transcription factors_Homo sapiens_hsa030221.42735183
26Circadian rhythm_Homo sapiens_hsa047101.42569155
27Nucleotide excision repair_Homo sapiens_hsa034201.34826321
28FoxO signaling pathway_Homo sapiens_hsa040681.34693514
29Pancreatic cancer_Homo sapiens_hsa052121.32689882
30mTOR signaling pathway_Homo sapiens_hsa041501.31827549
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30031426
32Small cell lung cancer_Homo sapiens_hsa052221.29895422
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29483068
34Renal cell carcinoma_Homo sapiens_hsa052111.21761249
35Glioma_Homo sapiens_hsa052141.21548569
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19934540
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18493649
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17890204
39Selenocompound metabolism_Homo sapiens_hsa004501.17772075
40Hippo signaling pathway_Homo sapiens_hsa043901.16002284
41p53 signaling pathway_Homo sapiens_hsa041151.15555376
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14631540
43TGF-beta signaling pathway_Homo sapiens_hsa043501.14597377
44Oocyte meiosis_Homo sapiens_hsa041141.14034689
45Inositol phosphate metabolism_Homo sapiens_hsa005621.13650804
46Hedgehog signaling pathway_Homo sapiens_hsa043401.11026595
47Wnt signaling pathway_Homo sapiens_hsa043101.05148544
48Basal cell carcinoma_Homo sapiens_hsa052171.03341463
49ErbB signaling pathway_Homo sapiens_hsa040121.03174962
50Viral carcinogenesis_Homo sapiens_hsa052030.97839904
51AMPK signaling pathway_Homo sapiens_hsa041520.95174762
52Melanoma_Homo sapiens_hsa052180.94079380
53Long-term potentiation_Homo sapiens_hsa047200.91879681
54Dorso-ventral axis formation_Homo sapiens_hsa043200.91207414
55Type II diabetes mellitus_Homo sapiens_hsa049300.90276753
56Acute myeloid leukemia_Homo sapiens_hsa052210.87960148
57Choline metabolism in cancer_Homo sapiens_hsa052310.87308687
58RNA polymerase_Homo sapiens_hsa030200.83919242
59Insulin signaling pathway_Homo sapiens_hsa049100.83488865
60Base excision repair_Homo sapiens_hsa034100.77173276
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75114400
62Tight junction_Homo sapiens_hsa045300.74548835
63Glucagon signaling pathway_Homo sapiens_hsa049220.74360876
64Proteoglycans in cancer_Homo sapiens_hsa052050.72854894
65Pathways in cancer_Homo sapiens_hsa052000.72756488
66Fatty acid biosynthesis_Homo sapiens_hsa000610.71649627
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.71367177
68Alcoholism_Homo sapiens_hsa050340.69330193
69Prolactin signaling pathway_Homo sapiens_hsa049170.67779384
70Hepatitis B_Homo sapiens_hsa051610.66523826
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65251695
72HTLV-I infection_Homo sapiens_hsa051660.61125020
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.60679335
74Melanogenesis_Homo sapiens_hsa049160.58812766
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58597556
76Gap junction_Homo sapiens_hsa045400.57868646
77Long-term depression_Homo sapiens_hsa047300.57325431
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57128423
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55814935
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.55493635
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54176146
82Propanoate metabolism_Homo sapiens_hsa006400.53302358
83Notch signaling pathway_Homo sapiens_hsa043300.52940549
84Insulin resistance_Homo sapiens_hsa049310.50466332
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50025944
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49788403
87Estrogen signaling pathway_Homo sapiens_hsa049150.49161702
88Focal adhesion_Homo sapiens_hsa045100.48022345
89Bladder cancer_Homo sapiens_hsa052190.42162963
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41862307
91Epstein-Barr virus infection_Homo sapiens_hsa051690.39925023
92T cell receptor signaling pathway_Homo sapiens_hsa046600.39453815
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.39367856
94Pyrimidine metabolism_Homo sapiens_hsa002400.39321103
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38545004
96Purine metabolism_Homo sapiens_hsa002300.37599464
97B cell receptor signaling pathway_Homo sapiens_hsa046620.37325588
98MAPK signaling pathway_Homo sapiens_hsa040100.34311327
99Rap1 signaling pathway_Homo sapiens_hsa040150.32274233
100Thyroid hormone synthesis_Homo sapiens_hsa049180.32111878

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