ZNF510

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a krueppel C2H2-type zinc-finger protein family member. The encoded protein is expressed in several cancer cell types and may be a biomarker for early diagnosis of these cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.80547329
2nuclear pore complex assembly (GO:0051292)5.49313431
3mitotic sister chromatid cohesion (GO:0007064)5.05995254
4nuclear pore organization (GO:0006999)4.93050001
5monoubiquitinated protein deubiquitination (GO:0035520)4.59260700
6regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.30237139
7cytoplasmic mRNA processing body assembly (GO:0033962)4.26304717
8positive regulation of microtubule polymerization (GO:0031116)4.18560607
9pore complex assembly (GO:0046931)3.76429031
10cerebral cortex radially oriented cell migration (GO:0021799)3.64290724
11phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.56174286
12histone H3-K4 trimethylation (GO:0080182)3.51484135
13negative regulation of neurotransmitter secretion (GO:0046929)3.51380062
14positive regulation of dendritic spine morphogenesis (GO:0061003)3.48091884
15positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.47709570
16pre-miRNA processing (GO:0031054)3.35770201
17peptidyl-lysine trimethylation (GO:0018023)3.32260171
18positive regulation of pseudopodium assembly (GO:0031274)3.30151697
19mitotic cytokinesis (GO:0000281)3.21518107
20regulation of RNA export from nucleus (GO:0046831)3.19155608
21mechanosensory behavior (GO:0007638)3.18002537
22regulation of pseudopodium assembly (GO:0031272)3.16512485
23histone H3-K9 methylation (GO:0051567)3.15895736
24interkinetic nuclear migration (GO:0022027)3.11667783
25regulation of histone H3-K9 methylation (GO:0051570)3.04890563
26microtubule anchoring (GO:0034453)3.03357927
27peptidyl-lysine dimethylation (GO:0018027)2.97957308
28negative regulation of microtubule depolymerization (GO:0007026)2.96180961
29histone H3-K9 modification (GO:0061647)2.92169219
30negative regulation of histone methylation (GO:0031061)2.88718377
31regulation of microtubule depolymerization (GO:0031114)2.88102722
32cytoskeleton-dependent cytokinesis (GO:0061640)2.81892293
33nucleus localization (GO:0051647)2.81732110
34establishment of nucleus localization (GO:0040023)2.81672465
35negative regulation of fibroblast apoptotic process (GO:2000270)2.73961825
36negative regulation of neurotransmitter transport (GO:0051589)2.73033414
37nerve growth factor signaling pathway (GO:0038180)2.72236070
38histone H3-K9 demethylation (GO:0033169)2.71435600
39prenylation (GO:0097354)2.70027936
40protein prenylation (GO:0018342)2.70027936
41startle response (GO:0001964)2.69942423
42histone H3-K4 methylation (GO:0051568)2.68441198
43regulation of skeletal muscle cell differentiation (GO:2001014)2.67930263
44mitotic spindle assembly checkpoint (GO:0007094)2.63828323
45establishment of protein localization to Golgi (GO:0072600)2.63129450
46regulation of sister chromatid segregation (GO:0033045)2.62202347
47regulation of mitotic sister chromatid separation (GO:0010965)2.62202347
48regulation of mitotic sister chromatid segregation (GO:0033047)2.62202347
49cytoplasmic microtubule organization (GO:0031122)2.61346302
50innervation (GO:0060384)2.60788698
51regulation of nucleobase-containing compound transport (GO:0032239)2.59555941
52peptidyl-threonine phosphorylation (GO:0018107)2.57468957
53mitotic chromosome condensation (GO:0007076)2.57243015
54mitotic spindle checkpoint (GO:0071174)2.55880702
55spindle assembly checkpoint (GO:0071173)2.55772243
56negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55720345
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55720345
58negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55720345
59negative regulation of mitotic sister chromatid separation (GO:2000816)2.55720345
60negative regulation of sister chromatid segregation (GO:0033046)2.55720345
61mitotic G2 DNA damage checkpoint (GO:0007095)2.55382287
62negative regulation of chromosome segregation (GO:0051985)2.53671429
63negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.53100422
64sister chromatid cohesion (GO:0007062)2.52009946
65glutamate receptor signaling pathway (GO:0007215)2.51152516
66peptidyl-threonine modification (GO:0018210)2.51144151
67peptidyl-lysine methylation (GO:0018022)2.50971000
68cerebral cortex development (GO:0021987)2.49853399
69nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.48827500
70DNA duplex unwinding (GO:0032508)2.47041844
71regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.46126293
72regulation of mitotic metaphase/anaphase transition (GO:0030071)2.46126293
73histone lysine methylation (GO:0034968)2.46053101
74regulation of microtubule polymerization (GO:0031113)2.44667587
75negative regulation of potassium ion transmembrane transport (GO:1901380)2.43572656
76DNA geometric change (GO:0032392)2.43525762
77protein targeting to lysosome (GO:0006622)2.43236161
78establishment of protein localization to vacuole (GO:0072666)2.43236161
79protein targeting to vacuole (GO:0006623)2.43236161
80spindle checkpoint (GO:0031577)2.42133291
81mitotic G2/M transition checkpoint (GO:0044818)2.41364445
82protein targeting to Golgi (GO:0000042)2.39769181
83neuronal action potential propagation (GO:0019227)2.39200315
84myelination in peripheral nervous system (GO:0022011)2.36447497
85peripheral nervous system axon ensheathment (GO:0032292)2.36447497
86regulation of chromosome segregation (GO:0051983)2.36339877
87regulation of histone methylation (GO:0031060)2.34639697
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.34150355
89regulation of centriole replication (GO:0046599)2.33894758
90behavioral response to cocaine (GO:0048148)2.33584310
91positive regulation of histone H3-K4 methylation (GO:0051571)2.33490920
92muscle cell cellular homeostasis (GO:0046716)2.33344270
93positive regulation of mitotic sister chromatid separation (GO:1901970)2.31943479
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.31943479
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.31943479
96regulation of NFAT protein import into nucleus (GO:0051532)2.31515460
97negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.31469608
98regulation of DNA methylation (GO:0044030)2.31339290
99ionotropic glutamate receptor signaling pathway (GO:0035235)2.31088985
100regulation of DNA endoreduplication (GO:0032875)2.30976272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.70712629
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.59253376
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.19374222
4EZH2_22144423_ChIP-Seq_EOC_Human3.08806498
5GBX2_23144817_ChIP-Seq_PC3_Human2.85437139
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.85389036
7E2F7_22180533_ChIP-Seq_HELA_Human2.76770654
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75226936
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68578603
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67188535
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.60917023
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59089058
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51839057
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.49306388
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25494375
16IGF1R_20145208_ChIP-Seq_DFB_Human2.16452783
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14979518
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.04825255
19TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.93089985
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92859382
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92797332
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90366644
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.78949992
24FUS_26573619_Chip-Seq_HEK293_Human1.76194367
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.75626440
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.71050734
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70360766
28STAT3_23295773_ChIP-Seq_U87_Human1.68664521
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67407852
30SMAD4_21799915_ChIP-Seq_A2780_Human1.67043074
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64577461
32* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63929512
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60730377
34EWS_26573619_Chip-Seq_HEK293_Human1.57402207
35YAP1_20516196_ChIP-Seq_MESCs_Mouse1.56564356
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56102186
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52975211
38TP53_16413492_ChIP-PET_HCT116_Human1.51258075
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50920240
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48223472
41P300_19829295_ChIP-Seq_ESCs_Human1.46714077
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44765054
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42527912
44SOX9_26525672_Chip-Seq_HEART_Mouse1.41306195
45* SMAD3_21741376_ChIP-Seq_EPCs_Human1.40857411
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40388966
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.39884014
48* TCF4_23295773_ChIP-Seq_U87_Human1.39521089
49TAF15_26573619_Chip-Seq_HEK293_Human1.38855135
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35803226
51TBX3_20139965_ChIP-Seq_ESCs_Mouse1.33609776
52TBX3_20139965_ChIP-Seq_MESCs_Mouse1.33160558
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32096196
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.32087868
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28773210
56SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28097914
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.25138331
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.24430038
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.23224754
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22247861
61FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22238439
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22082276
63ER_23166858_ChIP-Seq_MCF-7_Human1.20373798
64AR_21572438_ChIP-Seq_LNCaP_Human1.18618323
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18292129
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15287400
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.14739708
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14166151
69ZNF274_21170338_ChIP-Seq_K562_Hela1.12993147
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11866412
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10606239
72STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10546017
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10109736
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.09634240
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.08476677
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08177002
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.07846066
78* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07325755
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.06903856
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06795240
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06795240
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06165329
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04993692
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03157632
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02664605
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01837460
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01750022
88GF1B_26923725_Chip-Seq_HPCs_Mouse1.01126306
89AR_21909140_ChIP-Seq_LNCAP_Human1.00385564
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99952268
91AHR_22903824_ChIP-Seq_MCF-7_Human0.99497058
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98040267
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.97089259
94P53_22387025_ChIP-Seq_ESCs_Mouse0.96560255
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95140603
96RXR_22108803_ChIP-Seq_LS180_Human0.92657896
97RARB_27405468_Chip-Seq_BRAIN_Mouse0.92485745
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92078793
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91527888
100ELK1_19687146_ChIP-ChIP_HELA_Human0.90878938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.69090581
2MP0010352_gastrointestinal_tract_polyps4.50422125
3MP0005248_abnormal_Harderian_gland3.67907504
4MP0004145_abnormal_muscle_electrophysio3.14745914
5MP0005187_abnormal_penis_morphology2.91699499
6MP0002009_preneoplasia2.69209163
7MP0003868_abnormal_feces_composition2.67952667
8MP0004134_abnormal_chest_morphology2.66708087
9MP0002396_abnormal_hematopoietic_system2.55835204
10MP0003787_abnormal_imprinting2.18391342
11MP0010307_abnormal_tumor_latency2.14255727
12MP0003303_peritoneal_inflammation2.05942566
13MP0003890_abnormal_embryonic-extraembry2.00583222
14MP0008877_abnormal_DNA_methylation1.98224170
15MP0000462_abnormal_digestive_system1.92107547
16MP0004885_abnormal_endolymph1.85087617
17MP0000569_abnormal_digit_pigmentation1.74943771
18MP0000428_abnormal_craniofacial_morphol1.72142185
19MP0008058_abnormal_DNA_repair1.70907557
20MP0000778_abnormal_nervous_system1.69118491
21MP0000465_gastrointestinal_hemorrhage1.66585777
22MP0004270_analgesia1.54047622
23MP0003385_abnormal_body_wall1.53237177
24MP0003111_abnormal_nucleus_morphology1.41251954
25MP0004957_abnormal_blastocyst_morpholog1.38695068
26MP0003077_abnormal_cell_cycle1.37425110
27MP0009703_decreased_birth_body1.36361477
28MP0003119_abnormal_digestive_system1.34393834
29MP0001486_abnormal_startle_reflex1.32555300
30MP0001177_atelectasis1.32317927
31MP0004197_abnormal_fetal_growth/weight/1.31644452
32MP0003635_abnormal_synaptic_transmissio1.29205977
33MP0010094_abnormal_chromosome_stability1.29177601
34MP0003121_genomic_imprinting1.28863044
35MP0004233_abnormal_muscle_weight1.28194875
36MP0001984_abnormal_olfaction1.23872640
37MP0000631_abnormal_neuroendocrine_gland1.19798232
38MP0009046_muscle_twitch1.16990830
39MP0008569_lethality_at_weaning1.14141415
40MP0000647_abnormal_sebaceous_gland1.13067254
41MP0001299_abnormal_eye_distance/1.09891584
42MP0002084_abnormal_developmental_patter1.08960489
43MP0000537_abnormal_urethra_morphology1.08612276
44MP0006292_abnormal_olfactory_placode1.07889699
45MP0003937_abnormal_limbs/digits/tail_de1.05557778
46MP0010234_abnormal_vibrissa_follicle1.05239696
47MP0001672_abnormal_embryogenesis/_devel1.05144875
48MP0005380_embryogenesis_phenotype1.05144875
49MP0004859_abnormal_synaptic_plasticity1.05067224
50MP0002063_abnormal_learning/memory/cond1.04247047
51MP0003122_maternal_imprinting1.03568495
52MP0004811_abnormal_neuron_physiology1.03113290
53MP0008932_abnormal_embryonic_tissue1.01881310
54MP0003880_abnormal_central_pattern1.01809115
55MP0002177_abnormal_outer_ear0.98173157
56MP0003935_abnormal_craniofacial_develop0.97312447
57MP0000350_abnormal_cell_proliferation0.96873852
58MP0005499_abnormal_olfactory_system0.95821231
59MP0005394_taste/olfaction_phenotype0.95821231
60MP0003861_abnormal_nervous_system0.95623664
61MP0001730_embryonic_growth_arrest0.95587504
62MP0009745_abnormal_behavioral_response0.92838327
63MP0005423_abnormal_somatic_nervous0.91922652
64MP0002067_abnormal_sensory_capabilities0.91266402
65MP0002095_abnormal_skin_pigmentation0.91157780
66MP0003567_abnormal_fetal_cardiomyocyte0.90043420
67MP0002152_abnormal_brain_morphology0.89835463
68MP0003984_embryonic_growth_retardation0.89452500
69MP0002088_abnormal_embryonic_growth/wei0.87269204
70MP0002086_abnormal_extraembryonic_tissu0.86798909
71MP0002233_abnormal_nose_morphology0.84188085
72MP0002734_abnormal_mechanical_nocicepti0.84079683
73MP0003633_abnormal_nervous_system0.84071563
74MP0009672_abnormal_birth_weight0.82930792
75MP0003221_abnormal_cardiomyocyte_apopto0.82531309
76MP0003634_abnormal_glial_cell0.81293117
77MP0004084_abnormal_cardiac_muscle0.80900471
78MP0004185_abnormal_adipocyte_glucose0.80506382
79MP0002085_abnormal_embryonic_tissue0.79750364
80MP0005386_behavior/neurological_phenoty0.77657300
81MP0004924_abnormal_behavior0.77657300
82MP0003115_abnormal_respiratory_system0.77492238
83MP0002184_abnormal_innervation0.77074013
84MP0001697_abnormal_embryo_size0.77046180
85MP0002092_abnormal_eye_morphology0.76402421
86MP0002697_abnormal_eye_size0.74883963
87MP0002081_perinatal_lethality0.74333589
88MP0003631_nervous_system_phenotype0.73506390
89MP0000955_abnormal_spinal_cord0.73027651
90MP0000377_abnormal_hair_follicle0.72373421
91MP0002882_abnormal_neuron_morphology0.71845262
92MP0001293_anophthalmia0.71590595
93MP0004808_abnormal_hematopoietic_stem0.70784069
94MP0003632_abnormal_nervous_system0.69422652
95MP0001943_abnormal_respiration0.67519839
96MP0002064_seizures0.67359794
97MP0008789_abnormal_olfactory_epithelium0.66662904
98MP0005621_abnormal_cell_physiology0.66515930
99MP0004036_abnormal_muscle_relaxation0.64947045
100MP0000733_abnormal_muscle_development0.64470241

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)6.78153803
2Medulloblastoma (HP:0002885)5.87147453
3Hepatoblastoma (HP:0002884)5.80355028
4Colon cancer (HP:0003003)5.23834839
5Subacute progressive viral hepatitis (HP:0006572)5.18193986
6Neoplasm of the adrenal cortex (HP:0100641)4.63238944
7Thyroid carcinoma (HP:0002890)4.55789593
8Glioma (HP:0009733)4.35677583
9Abnormality of the astrocytes (HP:0100707)3.87459369
10Astrocytoma (HP:0009592)3.87459369
11Viral hepatitis (HP:0006562)3.52188460
12Stomach cancer (HP:0012126)3.49859512
13Neoplasm of the oral cavity (HP:0100649)3.44106344
14Transitional cell carcinoma of the bladder (HP:0006740)3.32092976
15Leiomyosarcoma (HP:0100243)3.30170308
16Uterine leiomyosarcoma (HP:0002891)3.30170308
17Epidermoid cyst (HP:0200040)3.19901223
18Neoplasm of the small intestine (HP:0100833)3.18800993
19Focal motor seizures (HP:0011153)3.15654880
20Acute lymphatic leukemia (HP:0006721)3.13210130
21Bladder neoplasm (HP:0009725)3.12697315
22Bladder carcinoma (HP:0002862)3.12697315
23Hyperventilation (HP:0002883)3.12250846
24Volvulus (HP:0002580)2.99329829
25Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.92084561
26Gastrointestinal carcinoma (HP:0002672)2.89680125
27Malignant gastrointestinal tract tumors (HP:0006749)2.89680125
28Rhabdomyosarcoma (HP:0002859)2.88433779
29Poor eye contact (HP:0000817)2.77361330
30Protruding tongue (HP:0010808)2.70211344
31Micronodular cirrhosis (HP:0001413)2.64319968
32Heterotopia (HP:0002282)2.62994421
33Deep philtrum (HP:0002002)2.43780887
34Neoplasm of the thyroid gland (HP:0100031)2.35198418
35Abnormal social behavior (HP:0012433)2.28324904
36Impaired social interactions (HP:0000735)2.28324904
37Truncal ataxia (HP:0002078)2.24706274
38Fibrous tissue neoplasm (HP:0012316)2.23368570
39Neuroectodermal neoplasm (HP:0030061)2.20932672
40Neuroepithelial neoplasm (HP:0030063)2.20932672
41Nervous tissue neoplasm (HP:0030060)2.20932672
42Anal stenosis (HP:0002025)2.18580696
43Difficulty running (HP:0009046)2.18408774
44Dysmetric saccades (HP:0000641)2.17005598
45Neoplasm of the adrenal gland (HP:0100631)2.16882143
46Fibroma (HP:0010614)2.15709318
47Malignant neoplasm of the central nervous system (HP:0100836)2.14736054
48Drooling (HP:0002307)2.14176667
49Hamartoma (HP:0010566)2.04915052
50Uterine neoplasm (HP:0010784)2.04802907
51Abnormality of chromosome segregation (HP:0002916)2.04415554
52Febrile seizures (HP:0002373)2.02487039
53Neoplasm of striated muscle (HP:0009728)2.02324946
54Embryonal neoplasm (HP:0002898)2.00348256
55Vertebral arch anomaly (HP:0008438)1.99835801
56Gaze-evoked nystagmus (HP:0000640)1.99791420
57Excessive salivation (HP:0003781)1.99214777
58Cubitus valgus (HP:0002967)1.97784119
59Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96951445
60Atonic seizures (HP:0010819)1.94532188
61Chromsome breakage (HP:0040012)1.91624877
62Increased number of teeth (HP:0011069)1.91068157
63Renal cell carcinoma (HP:0005584)1.89084867
64Neoplasm of the colon (HP:0100273)1.84972164
65Short chin (HP:0000331)1.84793856
66Pheochromocytoma (HP:0002666)1.84658825
67Oligodactyly (hands) (HP:0001180)1.82843233
68Termporal pattern (HP:0011008)1.80600833
69Insidious onset (HP:0003587)1.80600833
70Hepatocellular carcinoma (HP:0001402)1.80351155
71Focal seizures (HP:0007359)1.79576298
72Clitoromegaly (HP:0000057)1.78449302
73Macroorchidism (HP:0000053)1.76205821
74Asymmetry of the thorax (HP:0001555)1.76074701
75Decreased lacrimation (HP:0000633)1.75610805
76Global brain atrophy (HP:0002283)1.75293799
77Urinary urgency (HP:0000012)1.75248194
78Obsessive-compulsive behavior (HP:0000722)1.73931794
79Freckling (HP:0001480)1.73229382
80Neoplasm of the peripheral nervous system (HP:0100007)1.72817158
81Turricephaly (HP:0000262)1.72408486
82Intestinal polyposis (HP:0200008)1.70334998
83B lymphocytopenia (HP:0010976)1.67124408
84Hepatitis (HP:0012115)1.66758965
85Abnormality of the left ventricular outflow tract (HP:0011103)1.66744293
86Subaortic stenosis (HP:0001682)1.66744293
87Nephroblastoma (Wilms tumor) (HP:0002667)1.65464509
88Impaired vibration sensation in the lower limbs (HP:0002166)1.65380440
89Hemiparesis (HP:0001269)1.64554464
90Low anterior hairline (HP:0000294)1.63942712
91Renal cortical cysts (HP:0000803)1.63516276
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62920113
93Narrow palate (HP:0000189)1.62838997
94Abnormal biliary tract morphology (HP:0012440)1.62648443
95Abnormality of chromosome stability (HP:0003220)1.62529003
96Long nose (HP:0003189)1.62340758
97Lower limb muscle weakness (HP:0007340)1.61448827
98Cafe-au-lait spot (HP:0000957)1.61052672
99Intestinal atresia (HP:0011100)1.60983225
100Intestinal polyp (HP:0005266)1.60298117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.36702985
2MAP3K43.18313506
3BRD43.08191144
4CSNK1A1L2.77001931
5BCR2.69369800
6PNCK2.60319297
7CSNK1G12.49774409
8CSNK1G32.47979439
9CSNK1G22.33386678
10TNIK2.16388976
11CDK121.98904638
12CAMK1G1.97870592
13MARK11.87542670
14SGK21.86712473
15AKT31.75284977
16CAMKK21.67574863
17YES11.66616542
18LATS11.59646906
19FRK1.55863228
20ERBB31.51938508
21SCYL21.51611574
22MAP2K71.46117547
23MAP3K101.43678323
24NEK61.43515175
25SGK31.31331514
26SGK2231.29473958
27SGK4941.29473958
28STK38L1.28532723
29CDK61.26294175
30WNK11.25491136
31INSRR1.22819488
32NEK91.21545026
33NTRK31.17703009
34MKNK21.15640827
35CAMK1D1.15609804
36MAP3K21.12475608
37STK31.09817449
38STK41.09563307
39OBSCN1.07807865
40PIK3CA0.99842373
41TTK0.99161568
42MKNK10.96383910
43FGFR30.95185653
44PASK0.94162930
45PRPF4B0.93283099
46MARK20.92960317
47CDC70.92698725
48MAP2K40.92382295
49RAF10.91148781
50NLK0.90031241
51LATS20.88247894
52FGFR20.86378700
53UHMK10.82791037
54DMPK0.81890093
55KSR10.80178151
56CSNK1D0.79701259
57PKN20.75937217
58ATM0.75475229
59PDGFRA0.75305600
60SGK10.71941824
61MELK0.70197608
62ACVR1B0.70167288
63MAP3K70.69908080
64KSR20.69884452
65RET0.68902226
66MAPK100.68712003
67SRPK10.67003039
68CAMK40.66055820
69MAP3K60.64565415
70TAF10.64276295
71NUAK10.62398351
72CAMKK10.61927966
73FGFR10.61889241
74NTRK20.61212956
75STK380.59910150
76DYRK1A0.59464098
77STK240.59138433
78RPS6KB10.58963402
79TSSK60.58465641
80ATR0.56423769
81CSNK1E0.55839237
82CHEK10.55260992
83EPHA40.54494358
84EEF2K0.53611874
85MINK10.52708873
86CLK10.51552594
87PRKDC0.50465291
88CDK50.48714178
89CDK20.47755018
90GSK3B0.47714831
91MAP2K10.46582742
92PRKAA10.44973131
93MTOR0.44572530
94LMTK20.43287355
95TRIM280.43132262
96WNK30.42203164
97RPS6KA40.42106423
98CDK10.41059653
99CDK30.40785775
100RPS6KA30.39096903

Predicted pathways (KEGG)

RankGene SetZ-score
1Endometrial cancer_Homo sapiens_hsa052132.58507091
2Colorectal cancer_Homo sapiens_hsa052102.34866988
3Phosphatidylinositol signaling system_Homo sapiens_hsa040701.76529923
4Long-term potentiation_Homo sapiens_hsa047201.72630826
5Inositol phosphate metabolism_Homo sapiens_hsa005621.70273352
6Nicotine addiction_Homo sapiens_hsa050331.69208168
7Non-small cell lung cancer_Homo sapiens_hsa052231.59262425
8Chronic myeloid leukemia_Homo sapiens_hsa052201.54536281
9Adherens junction_Homo sapiens_hsa045201.52315729
10Thyroid hormone signaling pathway_Homo sapiens_hsa049191.50265147
11mTOR signaling pathway_Homo sapiens_hsa041501.42836193
12ErbB signaling pathway_Homo sapiens_hsa040121.40281973
13Dorso-ventral axis formation_Homo sapiens_hsa043201.38755740
14Glioma_Homo sapiens_hsa052141.38396713
15Cell cycle_Homo sapiens_hsa041101.37311370
16Lysine degradation_Homo sapiens_hsa003101.36927474
17Thyroid cancer_Homo sapiens_hsa052161.36818158
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36632951
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33263875
20FoxO signaling pathway_Homo sapiens_hsa040681.32250641
21MicroRNAs in cancer_Homo sapiens_hsa052061.32246052
22Glutamatergic synapse_Homo sapiens_hsa047241.31076482
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29939961
24GABAergic synapse_Homo sapiens_hsa047271.29193320
25Pancreatic cancer_Homo sapiens_hsa052121.26497513
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26303837
27mRNA surveillance pathway_Homo sapiens_hsa030151.25540796
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22268301
29Renal cell carcinoma_Homo sapiens_hsa052111.21313864
30Prostate cancer_Homo sapiens_hsa052151.19489934
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18606766
32Dopaminergic synapse_Homo sapiens_hsa047281.18289268
33Basal transcription factors_Homo sapiens_hsa030221.17209637
34Type II diabetes mellitus_Homo sapiens_hsa049301.15233952
35Oocyte meiosis_Homo sapiens_hsa041141.14732029
36Prolactin signaling pathway_Homo sapiens_hsa049171.10710169
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.07314130
38Estrogen signaling pathway_Homo sapiens_hsa049151.06454296
39Cholinergic synapse_Homo sapiens_hsa047251.05129375
40Choline metabolism in cancer_Homo sapiens_hsa052311.05007243
41Acute myeloid leukemia_Homo sapiens_hsa052211.04402989
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04058210
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02750973
44Non-homologous end-joining_Homo sapiens_hsa034501.02690802
45Wnt signaling pathway_Homo sapiens_hsa043101.02032640
46Alcoholism_Homo sapiens_hsa050341.01820192
47Circadian rhythm_Homo sapiens_hsa047101.00397693
48Gap junction_Homo sapiens_hsa045401.00351251
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00271580
50Oxytocin signaling pathway_Homo sapiens_hsa049210.99550786
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99286491
52Melanoma_Homo sapiens_hsa052180.99052204
53Long-term depression_Homo sapiens_hsa047300.97994221
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95103349
55Insulin signaling pathway_Homo sapiens_hsa049100.91045960
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90579485
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89982978
58AMPK signaling pathway_Homo sapiens_hsa041520.88848432
59Morphine addiction_Homo sapiens_hsa050320.88274820
60Circadian entrainment_Homo sapiens_hsa047130.88089632
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87829689
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86037658
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85607047
64Dilated cardiomyopathy_Homo sapiens_hsa054140.84044853
65Hippo signaling pathway_Homo sapiens_hsa043900.81032092
66Mismatch repair_Homo sapiens_hsa034300.80644573
67RNA degradation_Homo sapiens_hsa030180.79881942
68Basal cell carcinoma_Homo sapiens_hsa052170.79424438
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.78890076
70Amphetamine addiction_Homo sapiens_hsa050310.78642038
71cAMP signaling pathway_Homo sapiens_hsa040240.76987978
72Fatty acid biosynthesis_Homo sapiens_hsa000610.76889304
73Taste transduction_Homo sapiens_hsa047420.76004102
74RNA transport_Homo sapiens_hsa030130.74885011
75Nucleotide excision repair_Homo sapiens_hsa034200.74460128
76Renin secretion_Homo sapiens_hsa049240.73427120
77Propanoate metabolism_Homo sapiens_hsa006400.72653883
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.72202856
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71980084
80GnRH signaling pathway_Homo sapiens_hsa049120.71972343
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.71664655
82Small cell lung cancer_Homo sapiens_hsa052220.71402229
83Viral carcinogenesis_Homo sapiens_hsa052030.67451719
84Pancreatic secretion_Homo sapiens_hsa049720.66084790
85Gastric acid secretion_Homo sapiens_hsa049710.65167611
86Fanconi anemia pathway_Homo sapiens_hsa034600.64947863
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64854827
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64689320
89Thyroid hormone synthesis_Homo sapiens_hsa049180.64162753
90Proteoglycans in cancer_Homo sapiens_hsa052050.64047315
91Pathways in cancer_Homo sapiens_hsa052000.63786395
92Rap1 signaling pathway_Homo sapiens_hsa040150.63374242
93MAPK signaling pathway_Homo sapiens_hsa040100.63269666
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62667212
95Tight junction_Homo sapiens_hsa045300.62651949
96Insulin secretion_Homo sapiens_hsa049110.62145312
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62049590
98Ras signaling pathway_Homo sapiens_hsa040140.61721931
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60520937
100p53 signaling pathway_Homo sapiens_hsa041150.60435093

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