ZNF511

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.32097794
2ribosomal small subunit assembly (GO:0000028)5.09072392
3ribosomal small subunit biogenesis (GO:0042274)5.08640864
4regulation of mitochondrial translation (GO:0070129)5.00330387
5viral transcription (GO:0019083)4.83635068
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.76012864
7translational termination (GO:0006415)4.61932205
8translational elongation (GO:0006414)4.33990601
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27064934
10ribosomal large subunit biogenesis (GO:0042273)4.16270026
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.16037337
12cotranslational protein targeting to membrane (GO:0006613)4.06058280
13protein maturation by protein folding (GO:0022417)4.05172441
14protein targeting to ER (GO:0045047)4.03987295
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00981229
16proteasome assembly (GO:0043248)4.00048796
17ATP synthesis coupled proton transport (GO:0015986)3.98943341
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.98943341
19formation of translation preinitiation complex (GO:0001731)3.97524766
20pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.95502402
21pyrimidine nucleotide catabolic process (GO:0006244)3.91989383
22maturation of SSU-rRNA (GO:0030490)3.86899175
23viral life cycle (GO:0019058)3.85710646
24protein localization to endoplasmic reticulum (GO:0070972)3.85390349
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.84595895
26DNA strand elongation involved in DNA replication (GO:0006271)3.83403254
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.78944778
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78294350
29establishment of integrated proviral latency (GO:0075713)3.78020945
30negative regulation of ligase activity (GO:0051352)3.72227989
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72227989
32ribonucleoprotein complex biogenesis (GO:0022613)3.71436908
33DNA strand elongation (GO:0022616)3.70660240
34translational initiation (GO:0006413)3.69463712
35chaperone-mediated protein transport (GO:0072321)3.68968913
36cellular protein complex disassembly (GO:0043624)3.68400073
37oxidative phosphorylation (GO:0006119)3.67159734
38establishment of viral latency (GO:0019043)3.65671850
39metallo-sulfur cluster assembly (GO:0031163)3.60288889
40iron-sulfur cluster assembly (GO:0016226)3.60288889
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58875788
42telomere maintenance via semi-conservative replication (GO:0032201)3.58695539
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58273362
44translation (GO:0006412)3.57842338
45deoxyribonucleotide catabolic process (GO:0009264)3.57445982
46protein complex biogenesis (GO:0070271)3.56907695
47base-excision repair, AP site formation (GO:0006285)3.54484260
48protein targeting to mitochondrion (GO:0006626)3.53687256
49nuclear envelope reassembly (GO:0031468)3.52845790
50mitotic nuclear envelope reassembly (GO:0007084)3.52845790
51pseudouridine synthesis (GO:0001522)3.52057352
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51972628
53cellular component biogenesis (GO:0044085)3.50884357
54deoxyribose phosphate catabolic process (GO:0046386)3.49820031
55DNA unwinding involved in DNA replication (GO:0006268)3.48933932
56mitochondrial respiratory chain complex assembly (GO:0033108)3.47622792
57purine nucleotide salvage (GO:0032261)3.47297793
58guanosine-containing compound biosynthetic process (GO:1901070)3.46139134
59pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.41050180
60negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.40955381
61protein complex disassembly (GO:0043241)3.38771180
62establishment of protein localization to mitochondrion (GO:0072655)3.32743934
63regulation of cellular amino acid metabolic process (GO:0006521)3.31714826
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30343526
65pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.27105560
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24883671
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24883671
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24099211
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24099211
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24099211
71macromolecular complex disassembly (GO:0032984)3.22565864
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21614220
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21269556
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.21269556
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20802695
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20802695
77respiratory electron transport chain (GO:0022904)3.20194609
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18594351
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.18594351
80NADH dehydrogenase complex assembly (GO:0010257)3.18594351
81deoxyribose phosphate biosynthetic process (GO:0046385)3.18080593
822-deoxyribonucleotide biosynthetic process (GO:0009265)3.18080593
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17865385
84ribosome biogenesis (GO:0042254)3.15885462
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.14210380
86nucleotide salvage (GO:0043173)3.14150936
87IMP biosynthetic process (GO:0006188)3.13725882
88mitochondrial calcium ion transport (GO:0006851)3.12987135
89electron transport chain (GO:0022900)3.11932306
90GTP biosynthetic process (GO:0006183)3.09713654
91positive regulation of ligase activity (GO:0051351)3.09641763
92protein localization to mitochondrion (GO:0070585)3.09241654
93purine nucleobase biosynthetic process (GO:0009113)3.09033820
94peptidyl-arginine omega-N-methylation (GO:0035247)3.08277704
95UTP biosynthetic process (GO:0006228)3.06860176
96histone arginine methylation (GO:0034969)3.06703363
97rRNA modification (GO:0000154)3.04991208
98rRNA processing (GO:0006364)3.03096417
99nucleobase-containing small molecule interconversion (GO:0015949)3.01417326
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01057645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.48302482
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89826509
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.74474501
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45469748
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.40721217
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11857809
7MYC_18358816_ChIP-ChIP_MESCs_Mouse3.08427129
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84717787
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.82296825
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76580058
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.70143281
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58893021
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.58702993
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58173395
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50419029
16XRN2_22483619_ChIP-Seq_HELA_Human2.48776286
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.47887511
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42721336
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40839983
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33307991
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30338419
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24795058
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22701102
24GABP_19822575_ChIP-Seq_HepG2_Human2.17891839
25DCP1A_22483619_ChIP-Seq_HELA_Human2.16624780
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07655267
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06755042
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.03483937
29FOXP3_21729870_ChIP-Seq_TREG_Human1.93538562
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92130002
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91881753
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.89228997
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85262336
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84736057
35TTF2_22483619_ChIP-Seq_HELA_Human1.82103993
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79727643
37VDR_23849224_ChIP-Seq_CD4+_Human1.78891204
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78374874
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77092679
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76886337
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.67849762
42VDR_21846776_ChIP-Seq_THP-1_Human1.64868573
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64469091
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.63388303
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59926143
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57922841
47ZNF263_19887448_ChIP-Seq_K562_Human1.51551144
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51291292
49* KDM5A_27292631_Chip-Seq_BREAST_Human1.49036648
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48569355
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47968544
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46208311
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41050042
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40401351
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40301898
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38881628
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38311974
58CIITA_25753668_ChIP-Seq_RAJI_Human1.35782454
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34913842
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34776971
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33119179
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31988080
63MYC_22102868_ChIP-Seq_BL_Human1.30518259
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.30502570
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29753264
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.29628497
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29071072
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28131190
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28115829
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21947693
71FOXP1_21924763_ChIP-Seq_HESCs_Human1.21771069
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21701946
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20082234
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19650693
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17980062
76ELK1_19687146_ChIP-ChIP_HELA_Human1.12594857
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11785426
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09670112
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08004676
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06690309
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03329555
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02061125
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01809778
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.00949263
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99793215
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99280922
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98296694
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97529168
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.97143718
90P68_20966046_ChIP-Seq_HELA_Human0.96681530
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96674759
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96381323
93CTCF_26484167_Chip-Seq_Bcells_Mouse0.96369241
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95455516
95LXR_22292898_ChIP-Seq_THP-1_Human0.94540932
96MYC_18940864_ChIP-ChIP_HL60_Human0.94451943
97TFEB_21752829_ChIP-Seq_HELA_Human0.94271046
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94267715
99BCL6_27268052_Chip-Seq_Bcells_Human0.93210122
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.93171279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.98943642
2MP0010094_abnormal_chromosome_stability3.67072857
3MP0003111_abnormal_nucleus_morphology3.59547296
4MP0003806_abnormal_nucleotide_metabolis3.51287306
5MP0004957_abnormal_blastocyst_morpholog3.39855665
6MP0008058_abnormal_DNA_repair3.10165690
7MP0008932_abnormal_embryonic_tissue3.08625791
8MP0003077_abnormal_cell_cycle3.07694597
9MP0006036_abnormal_mitochondrial_physio3.04888447
10MP0008007_abnormal_cellular_replicative2.67316610
11MP0006035_abnormal_mitochondrial_morpho2.57108575
12MP0010030_abnormal_orbit_morphology2.53571459
13MP0003186_abnormal_redox_activity2.49884067
14MP0003786_premature_aging2.21301271
15MP0009697_abnormal_copulation1.99381062
16MP0005451_abnormal_body_composition1.98774379
17MP0005075_abnormal_melanosome_morpholog1.97802904
18MP0008260_abnormal_autophagy1.94399557
19MP0001730_embryonic_growth_arrest1.81609141
20MP0004147_increased_porphyrin_level1.75322362
21MP0003718_maternal_effect1.68504159
22MP0000750_abnormal_muscle_regeneration1.67157710
23MP0000490_abnormal_crypts_of1.65433548
24MP0000358_abnormal_cell_content/1.62561553
25MP0000350_abnormal_cell_proliferation1.59798724
26MP0000313_abnormal_cell_death1.57422504
27MP0009333_abnormal_splenocyte_physiolog1.55466638
28MP0008789_abnormal_olfactory_epithelium1.55199958
29MP0008995_early_reproductive_senescence1.47659189
30MP0001727_abnormal_embryo_implantation1.47646047
31MP0000537_abnormal_urethra_morphology1.44386333
32MP0002163_abnormal_gland_morphology1.44299830
33MP0000749_muscle_degeneration1.39460035
34MP0003315_abnormal_perineum_morphology1.36150828
35MP0009379_abnormal_foot_pigmentation1.34357554
36MP0001293_anophthalmia1.31967968
37MP0002653_abnormal_ependyma_morphology1.31522469
38MP0005058_abnormal_lysosome_morphology1.31078171
39MP0002877_abnormal_melanocyte_morpholog1.31031008
40MP0002019_abnormal_tumor_incidence1.30184885
41MP0005501_abnormal_skin_physiology1.27973717
42MP0009278_abnormal_bone_marrow1.27433605
43MP0000372_irregular_coat_pigmentation1.25291801
44MP0002132_abnormal_respiratory_system1.23208303
45MP0001873_stomach_inflammation1.21855481
46MP0002080_prenatal_lethality1.21317326
47MP0004185_abnormal_adipocyte_glucose1.19910139
48MP0001764_abnormal_homeostasis1.18112036
49MP0003123_paternal_imprinting1.12695902
50MP0003646_muscle_fatigue1.12082410
51MP0006292_abnormal_olfactory_placode1.11802229
52MP0001672_abnormal_embryogenesis/_devel1.10602795
53MP0005380_embryogenesis_phenotype1.10602795
54MP0005330_cardiomyopathy1.08405024
55MP0001697_abnormal_embryo_size1.06945027
56MP0005408_hypopigmentation1.05731183
57MP0004233_abnormal_muscle_weight0.99782477
58MP0005394_taste/olfaction_phenotype0.99096657
59MP0005499_abnormal_olfactory_system0.99096657
60MP0001849_ear_inflammation0.96720547
61MP0002085_abnormal_embryonic_tissue0.95679042
62MP0001529_abnormal_vocalization0.94193281
63MP0002210_abnormal_sex_determination0.93837656
64MP0000747_muscle_weakness0.92571009
65MP0001346_abnormal_lacrimal_gland0.91898802
66MP0003984_embryonic_growth_retardation0.91735577
67MP0000678_abnormal_parathyroid_gland0.89048889
68MP0001853_heart_inflammation0.87687110
69MP0002088_abnormal_embryonic_growth/wei0.84945717
70MP0000751_myopathy0.82820901
71MP0002095_abnormal_skin_pigmentation0.81737294
72MP0001145_abnormal_male_reproductive0.80964162
73MP0003763_abnormal_thymus_physiology0.80786460
74MP0000703_abnormal_thymus_morphology0.80597564
75MP0009053_abnormal_anal_canal0.78794075
76MP0003221_abnormal_cardiomyocyte_apopto0.78406238
77MP0004858_abnormal_nervous_system0.77527902
78MP0000049_abnormal_middle_ear0.76488650
79MP0002234_abnormal_pharynx_morphology0.76049810
80MP0002722_abnormal_immune_system0.75646388
81MP0000015_abnormal_ear_pigmentation0.75541367
82MP0001661_extended_life_span0.75265598
83MP0001881_abnormal_mammary_gland0.75154510
84MP0002111_abnormal_tail_morphology0.72693007
85MP0000653_abnormal_sex_gland0.72618552
86MP0002429_abnormal_blood_cell0.71782641
87MP0002796_impaired_skin_barrier0.71746826
88MP0008057_abnormal_DNA_replication0.69945318
89MP0005464_abnormal_platelet_physiology0.69902412
90MP0002160_abnormal_reproductive_system0.68740570
91MP0002249_abnormal_larynx_morphology0.68314652
92MP0002398_abnormal_bone_marrow0.67525056
93MP0000516_abnormal_urinary_system0.67435311
94MP0005367_renal/urinary_system_phenotyp0.67435311
95MP0001119_abnormal_female_reproductive0.66391263
96MP0005319_abnormal_enzyme/_coenzyme0.66198481
97MP0000759_abnormal_skeletal_muscle0.65719857
98MP0005266_abnormal_metabolism0.65527747
99MP0001929_abnormal_gametogenesis0.65405073
100MP0000343_altered_response_to0.65389328

Predicted human phenotypes

RankGene SetZ-score
1Increased intramyocellular lipid droplets (HP:0012240)4.81680066
2Abnormal mitochondria in muscle tissue (HP:0008316)4.77486626
3Increased muscle lipid content (HP:0009058)4.60808431
4Mitochondrial inheritance (HP:0001427)4.58954184
5Hepatocellular necrosis (HP:0001404)4.54283850
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.52966557
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.52966557
8Acute necrotizing encephalopathy (HP:0006965)4.33037786
9Lipid accumulation in hepatocytes (HP:0006561)4.24856474
10Increased hepatocellular lipid droplets (HP:0006565)4.09412401
11Abnormality of cells of the erythroid lineage (HP:0012130)4.07005999
12Increased CSF lactate (HP:0002490)4.04026606
13Acute encephalopathy (HP:0006846)3.99598977
14Abnormal number of erythroid precursors (HP:0012131)3.97763585
15Hepatic necrosis (HP:0002605)3.96592975
16Reticulocytopenia (HP:0001896)3.91312167
17Ragged-red muscle fibers (HP:0003200)3.78923378
18Renal Fanconi syndrome (HP:0001994)3.60173160
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.45504859
20Microvesicular hepatic steatosis (HP:0001414)3.39363976
21IgM deficiency (HP:0002850)3.39251621
22Exercise intolerance (HP:0003546)3.38871013
23Lactic acidosis (HP:0003128)3.28348686
24Increased serum lactate (HP:0002151)3.25881226
25Type I transferrin isoform profile (HP:0003642)3.25387720
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.24681527
27Aplastic anemia (HP:0001915)3.19413997
28Progressive muscle weakness (HP:0003323)3.17606804
29Testicular atrophy (HP:0000029)3.15449317
30Progressive macrocephaly (HP:0004481)3.12628839
31Cerebral edema (HP:0002181)3.03124365
32Respiratory difficulties (HP:0002880)3.00209476
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.95788394
34Macrocytic anemia (HP:0001972)2.93652411
35Microretrognathia (HP:0000308)2.70978506
36Rhabdomyolysis (HP:0003201)2.66529308
37Respiratory failure (HP:0002878)2.59183575
38Abnormal protein glycosylation (HP:0012346)2.59177716
39Abnormal glycosylation (HP:0012345)2.59177716
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59177716
41Abnormal protein N-linked glycosylation (HP:0012347)2.59177716
42Dicarboxylic aciduria (HP:0003215)2.57974617
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57974617
44Myoglobinuria (HP:0002913)2.54921083
45Broad distal phalanx of finger (HP:0009836)2.52464784
46Exertional dyspnea (HP:0002875)2.52449283
47Abnormality of glycolysis (HP:0004366)2.51312054
48Pancytopenia (HP:0001876)2.50014183
49Increased serum pyruvate (HP:0003542)2.42710611
50Pallor (HP:0000980)2.40962487
51Rough bone trabeculation (HP:0100670)2.40257465
52Reduced antithrombin III activity (HP:0001976)2.36538588
53Cerebral palsy (HP:0100021)2.36399676
54Muscle fiber atrophy (HP:0100295)2.30349400
55Opisthotonus (HP:0002179)2.29049065
56Multiple enchondromatosis (HP:0005701)2.12475201
573-Methylglutaconic aciduria (HP:0003535)2.03952995
58Abnormality of reticulocytes (HP:0004312)2.01924098
59Methylmalonic aciduria (HP:0012120)1.98835718
60Lethargy (HP:0001254)1.98457839
61Hypoplastic pelvis (HP:0008839)1.96865688
62Gout (HP:0001997)1.95638679
63Emotional lability (HP:0000712)1.94161574
64Hepatosplenomegaly (HP:0001433)1.88054957
65Abnormal trabecular bone morphology (HP:0100671)1.87575698
66Leukodystrophy (HP:0002415)1.87105052
67IgA deficiency (HP:0002720)1.86978018
68Abnormality of the anterior horn cell (HP:0006802)1.85090856
69Degeneration of anterior horn cells (HP:0002398)1.85090856
70Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82872161
71B lymphocytopenia (HP:0010976)1.81730240
72Myopathic facies (HP:0002058)1.81519807
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80552819
74Death in infancy (HP:0001522)1.80425283
75Abnormal number of incisors (HP:0011064)1.79569318
76Abnormal gallbladder physiology (HP:0012438)1.75576187
77Cholecystitis (HP:0001082)1.75576187
78Nemaline bodies (HP:0003798)1.74306353
79Hypergonadotropic hypogonadism (HP:0000815)1.73796901
80Type 2 muscle fiber atrophy (HP:0003554)1.73609687
81Facial cleft (HP:0002006)1.73410531
82Muscle stiffness (HP:0003552)1.72878822
83Cleft eyelid (HP:0000625)1.72062868
84Abnormality of renal resorption (HP:0011038)1.71886642
85Aplasia/hypoplasia of the uterus (HP:0008684)1.70838053
86Vertebral compression fractures (HP:0002953)1.68970175
87Selective tooth agenesis (HP:0001592)1.68675933
88Progressive microcephaly (HP:0000253)1.68666240
89Increased IgM level (HP:0003496)1.67603084
90Neutropenia (HP:0001875)1.67588346
91Hypertensive crisis (HP:0100735)1.66407652
92Abnormality of T cell physiology (HP:0011840)1.66335528
93Hyperammonemia (HP:0001987)1.66239409
94Exercise-induced muscle cramps (HP:0003710)1.66234922
95Prolonged neonatal jaundice (HP:0006579)1.64213071
96Abnormality of the preputium (HP:0100587)1.64139819
97CNS demyelination (HP:0007305)1.62512228
98Hyperglycinemia (HP:0002154)1.61598527
99Chromsome breakage (HP:0040012)1.59469975
100Hyperphosphaturia (HP:0003109)1.56661779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.36281379
2NME24.71328435
3TESK23.89569268
4BUB13.69246538
5BCKDK3.42642772
6IRAK32.54334750
7CDC72.23000756
8VRK12.16749906
9TESK12.15146298
10SMG12.13023666
11ARAF2.11450121
12STK162.08134532
13NEK12.05546624
14SRPK12.03361723
15ZAK2.02460885
16KDR1.92300977
17SCYL21.92158606
18MAP3K111.77262567
19PIM21.71741458
20PBK1.57932724
21FES1.57074459
22LIMK11.55882131
23CDK191.45184589
24AURKA1.41342835
25NME11.40802561
26TLK11.35972792
27NUAK11.35205702
28TAF11.32223663
29TAOK21.32017645
30TTK1.30186485
31BRAF1.27394059
32CHEK21.21867778
33ERN11.18887988
34CSNK1G31.11987219
35ABL21.11162785
36CDK81.08468633
37DAPK11.08331081
38ILK1.07971930
39ATR1.07882916
40CDK71.03528485
41BRSK11.01055856
42AURKB0.96216518
43PLK10.93796514
44LRRK20.92924098
45CSNK1G10.90400523
46DYRK30.89048276
47EIF2AK10.85425683
48TRIB30.84991567
49CSNK1A1L0.83608497
50PAK10.81598926
51PAK40.80982142
52EPHA20.79174467
53PLK30.78413652
54PASK0.75966277
55MAP2K70.74248851
56MAP3K80.72264045
57PRKCI0.71706190
58RPS6KB20.67940234
59RPS6KA50.66810620
60MAP2K30.66065120
61TBK10.66020718
62MAP4K20.65682833
63TRIM280.62760587
64CDK40.62672563
65MAPKAPK30.61231586
66CCNB10.60582295
67PLK40.58656749
68CSNK1G20.58291846
69RPS6KA40.57071265
70DAPK30.54809768
71IRAK20.54047265
72CHEK10.53827526
73CSNK2A10.52979832
74RAF10.52880306
75MAPK110.52009938
76NEK20.51561862
77CSNK2A20.51544280
78WEE10.50780613
79PRPF4B0.50612493
80STK40.44981636
81DYRK20.43947330
82AKT20.43908957
83MOS0.42360737
84PRKD30.41688912
85PDK20.41493794
86TSSK60.36454291
87EIF2AK20.36435514
88OBSCN0.34845084
89BMX0.34017878
90FER0.32307054
91CDK11A0.32249580
92BRSK20.29223625
93MAP3K100.28298922
94CDK20.25775365
95CDK140.25643482
96MAP4K10.25616595
97CDK150.24155790
98IKBKB0.22814138
99PIM10.22606554
100STK100.22473377

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.54679973
2Proteasome_Homo sapiens_hsa030504.26545724
3DNA replication_Homo sapiens_hsa030304.18973190
4Base excision repair_Homo sapiens_hsa034103.27526947
5Oxidative phosphorylation_Homo sapiens_hsa001903.00592738
6Parkinsons disease_Homo sapiens_hsa050122.87802602
7Sulfur relay system_Homo sapiens_hsa041222.78300998
8Mismatch repair_Homo sapiens_hsa034302.76742518
9Pyrimidine metabolism_Homo sapiens_hsa002402.43335130
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40319018
11RNA polymerase_Homo sapiens_hsa030202.38291282
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29321636
13Huntingtons disease_Homo sapiens_hsa050162.07724000
14Nucleotide excision repair_Homo sapiens_hsa034202.07394122
15Homologous recombination_Homo sapiens_hsa034402.07122035
16Spliceosome_Homo sapiens_hsa030401.99498993
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99407623
18Biosynthesis of amino acids_Homo sapiens_hsa012301.82358127
19Alzheimers disease_Homo sapiens_hsa050101.70402311
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68266512
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68254145
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68176568
23RNA transport_Homo sapiens_hsa030131.64960257
24Pentose phosphate pathway_Homo sapiens_hsa000301.63888166
25Fanconi anemia pathway_Homo sapiens_hsa034601.61792801
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61575531
27Carbon metabolism_Homo sapiens_hsa012001.59737401
28Folate biosynthesis_Homo sapiens_hsa007901.52544144
29Fatty acid elongation_Homo sapiens_hsa000621.43129565
30One carbon pool by folate_Homo sapiens_hsa006701.33865313
31Glutathione metabolism_Homo sapiens_hsa004801.27675059
32Purine metabolism_Homo sapiens_hsa002301.27418176
33Fructose and mannose metabolism_Homo sapiens_hsa000511.26419161
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.25479341
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17449318
36Pyruvate metabolism_Homo sapiens_hsa006201.14946211
37Cell cycle_Homo sapiens_hsa041101.13755006
38Galactose metabolism_Homo sapiens_hsa000521.13336848
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13042540
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08999457
41Non-homologous end-joining_Homo sapiens_hsa034501.03249024
42Primary immunodeficiency_Homo sapiens_hsa053400.97765180
43RNA degradation_Homo sapiens_hsa030180.96314002
44Basal transcription factors_Homo sapiens_hsa030220.95645794
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95303259
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94879688
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93843945
48Cardiac muscle contraction_Homo sapiens_hsa042600.93116590
49Sulfur metabolism_Homo sapiens_hsa009200.85175436
50N-Glycan biosynthesis_Homo sapiens_hsa005100.85169916
51Metabolic pathways_Homo sapiens_hsa011000.78736553
52Protein export_Homo sapiens_hsa030600.69497270
53Selenocompound metabolism_Homo sapiens_hsa004500.67168863
54p53 signaling pathway_Homo sapiens_hsa041150.66096277
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63637315
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63058366
57Peroxisome_Homo sapiens_hsa041460.62445103
58mRNA surveillance pathway_Homo sapiens_hsa030150.61941863
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60096748
60Epstein-Barr virus infection_Homo sapiens_hsa051690.59660847
61Systemic lupus erythematosus_Homo sapiens_hsa053220.59129573
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.56731752
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49483889
64Fatty acid metabolism_Homo sapiens_hsa012120.46970242
65Arginine and proline metabolism_Homo sapiens_hsa003300.46128947
66Steroid biosynthesis_Homo sapiens_hsa001000.45955414
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45904532
68Phenylalanine metabolism_Homo sapiens_hsa003600.45360060
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.44930558
70Vitamin B6 metabolism_Homo sapiens_hsa007500.44089624
71Propanoate metabolism_Homo sapiens_hsa006400.41313591
72Bladder cancer_Homo sapiens_hsa052190.37524157
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36357282
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36354773
75Alcoholism_Homo sapiens_hsa050340.34932561
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.34411405
77Viral carcinogenesis_Homo sapiens_hsa052030.32809407
78HTLV-I infection_Homo sapiens_hsa051660.32163876
79Herpes simplex infection_Homo sapiens_hsa051680.30238764
80Shigellosis_Homo sapiens_hsa051310.28852628
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27865171
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27022371
83Regulation of autophagy_Homo sapiens_hsa041400.25482267
84Tyrosine metabolism_Homo sapiens_hsa003500.24393440
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23325252
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22242445
87Apoptosis_Homo sapiens_hsa042100.22059492
88Vibrio cholerae infection_Homo sapiens_hsa051100.19449321
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17259650
90Fatty acid degradation_Homo sapiens_hsa000710.14784392
91Oocyte meiosis_Homo sapiens_hsa041140.14173053
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12867340
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12711795
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.09039925
95Legionellosis_Homo sapiens_hsa051340.07815696
96Basal cell carcinoma_Homo sapiens_hsa052170.07600251
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07044108
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.06989117
99Antigen processing and presentation_Homo sapiens_hsa046120.06074707
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.04361296

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