ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	very-low-density lipoprotein particle assembly (GO:0034379)	6.25845669
2	negative regulation of fibrinolysis (GO:0051918)	6.25414380
3	urea metabolic process (GO:0019627)	6.06776166
4	regulation of fibrinolysis (GO:0051917)	5.92375217
5	urea cycle (GO:0000050)	5.86272757
6	plasma lipoprotein particle assembly (GO:0034377)	5.61120396
7	nitrogen cycle metabolic process (GO:0071941)	5.50297474
8	epoxygenase P450 pathway (GO:0019373)	5.44469868
9	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	5.40422405
10	regulation of bile acid biosynthetic process (GO:0070857)	5.39682358
11	regulation of cholesterol esterification (GO:0010872)	5.26435992
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.20280581
13	L-phenylalanine metabolic process (GO:0006558)	5.20280581
14	cellular glucuronidation (GO:0052695)	5.15997335
15	L-phenylalanine catabolic process (GO:0006559)	5.15873413
16	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.15873413
17	peptidyl-glutamic acid carboxylation (GO:0017187)	5.15651488
18	protein carboxylation (GO:0018214)	5.15651488
19	regulation of protein activation cascade (GO:2000257)	5.09211927
20	protein-lipid complex assembly (GO:0065005)	5.07719567
21	intestinal absorption (GO:0050892)	5.01790342
22	negative regulation of cholesterol transport (GO:0032375)	4.98865213
23	negative regulation of sterol transport (GO:0032372)	4.98865213
24	glucuronate metabolic process (GO:0019585)	4.98205626
25	uronic acid metabolic process (GO:0006063)	4.98205626
26	proline metabolic process (GO:0006560)	4.79151672
27	regulation of complement activation (GO:0030449)	4.76447069
28	macromolecular complex remodeling (GO:0034367)	4.74607363
29	plasma lipoprotein particle remodeling (GO:0034369)	4.74607363
30	protein-lipid complex remodeling (GO:0034368)	4.74607363
31	glyoxylate metabolic process (GO:0046487)	4.69305595
32	intestinal cholesterol absorption (GO:0030299)	4.66278835
33	cholesterol efflux (GO:0033344)	4.64805668
34	NADH metabolic process (GO:0006734)	4.60154031
35	phospholipid efflux (GO:0033700)	4.55939850
36	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.51096234
37	fat-soluble vitamin biosynthetic process (GO:0042362)	4.49747406
38	positive regulation of triglyceride lipase activity (GO:0061365)	4.46470871
39	positive regulation of lipoprotein lipase activity (GO:0051006)	4.46470871
40	regulation of cholesterol homeostasis (GO:2000188)	4.43423730
41	plasma lipoprotein particle organization (GO:0071827)	4.40396318
42	drug catabolic process (GO:0042737)	4.39032098
43	exogenous drug catabolic process (GO:0042738)	4.38580451
44	ethanol oxidation (GO:0006069)	4.32886369
45	high-density lipoprotein particle remodeling (GO:0034375)	4.25337990
46	low-density lipoprotein particle remodeling (GO:0034374)	4.22116640
47	protein-lipid complex subunit organization (GO:0071825)	4.18585203
48	complement activation, alternative pathway (GO:0006957)	4.17879248
49	regulation of triglyceride catabolic process (GO:0010896)	4.16159250
50	blood coagulation, intrinsic pathway (GO:0007597)	4.14319631
51	drug metabolic process (GO:0017144)	4.13061828
52	fibrinolysis (GO:0042730)	4.09483661
53	bile acid and bile salt transport (GO:0015721)	4.07241127
54	angiotensin maturation (GO:0002003)	4.07182871
55	bile acid metabolic process (GO:0008206)	4.00736665
56	triglyceride homeostasis (GO:0070328)	3.95328213
57	acylglycerol homeostasis (GO:0055090)	3.95328213
58	serine family amino acid biosynthetic process (GO:0009070)	3.89300795
59	acute-phase response (GO:0006953)	3.87735250
60	glycine metabolic process (GO:0006544)	3.86502758
61	arginine metabolic process (GO:0006525)	3.81208023
62	reverse cholesterol transport (GO:0043691)	3.79714506
63	glutamine family amino acid biosynthetic process (GO:0009084)	3.79265581
64	complement activation, classical pathway (GO:0006958)	3.77637394
65	flavonoid metabolic process (GO:0009812)	3.69864758
66	diacylglycerol metabolic process (GO:0046339)	3.65788976
67	cholesterol homeostasis (GO:0042632)	3.65783474
68	omega-hydroxylase P450 pathway (GO:0097267)	3.64450234
69	negative regulation of blood coagulation (GO:0030195)	3.63462248
70	negative regulation of hemostasis (GO:1900047)	3.63462248
71	proline biosynthetic process (GO:0006561)	3.63195981
72	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.62851192
73	regulation of plasminogen activation (GO:0010755)	3.62224546
74	phenylpropanoid metabolic process (GO:0009698)	3.61095446
75	sterol homeostasis (GO:0055092)	3.60680355
76	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.56680541
77	plasma lipoprotein particle clearance (GO:0034381)	3.55649783
78	lipoprotein metabolic process (GO:0042157)	3.54121979
79	hormone catabolic process (GO:0042447)	3.53501842
80	protein activation cascade (GO:0072376)	3.51990099
81	serine family amino acid catabolic process (GO:0009071)	3.50773274
82	ethanol metabolic process (GO:0006067)	3.49646435
83	fructose metabolic process (GO:0006000)	3.42723507
84	negative regulation of coagulation (GO:0050819)	3.38980363
85	complement activation (GO:0006956)	3.35387577
86	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.30206572
87	drug transmembrane transport (GO:0006855)	3.29861342
88	polyketide metabolic process (GO:0030638)	3.29455631
89	doxorubicin metabolic process (GO:0044598)	3.29455631
90	daunorubicin metabolic process (GO:0044597)	3.29455631
91	negative regulation of wound healing (GO:0061045)	3.22342213
92	serine family amino acid metabolic process (GO:0009069)	3.20654468
93	positive regulation of lipid catabolic process (GO:0050996)	3.20616728
94	heme transport (GO:0015886)	3.18251033
95	glutamate metabolic process (GO:0006536)	3.13982458
96	maintenance of gastrointestinal epithelium (GO:0030277)	3.13368942
97	regulation of cholesterol metabolic process (GO:0090181)	3.12291282
98	drug transport (GO:0015893)	3.10803495
99	regulation of humoral immune response (GO:0002920)	3.09454129
100	bile acid biosynthetic process (GO:0006699)	3.08306144

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	7.34454254
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	4.36740669
3	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.95383691
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.92011147
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.35865908
6	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.19940345
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.08160034
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.97930599
9	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.89863922
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.55116784
11	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.49514557
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.38071672
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.10534953
14	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.09698072
15	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.92626144
16	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.91192522
17	LXR_22292898_ChIP-Seq_THP-1_Human	1.88476940
18	GATA6_25053715_ChIP-Seq_YYC3_Human	1.84207171
19	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.83135882
20	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.80003180
21	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.74159102
22	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.72533433
23	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.69563569
24	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.67102931
25	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.62384855
26	GATA4_25053715_ChIP-Seq_YYC3_Human	1.61989244
27	RACK7_27058665_Chip-Seq_MCF-7_Human	1.53370184
28	AR_21909140_ChIP-Seq_LNCAP_Human	1.53047950
29	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.51871677
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.51191676
31	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.46641899
32	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.43039175
33	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.42703576
34	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38054876
35	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.36426988
36	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.35329064
37	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.35098887
38	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.29424476
39	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.28464289
40	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.26423260
41	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.23884568
42	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.23372141
43	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.22344066
44	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.21408846
45	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.19556917
46	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.19085641
47	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.18929280
48	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.17683544
49	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.16844872
50	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.16498128
51	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.14977062
52	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.14875384
53	BCOR_27268052_Chip-Seq_Bcells_Human	1.14836770
54	SOX2_20726797_ChIP-Seq_SW620_Human	1.14601770
55	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13821147
56	CLOCK_20551151_ChIP-Seq_293T_Human	1.13040954
57	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.10734533
58	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.09631330
59	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.08371364
60	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.08179948
61	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.07550725
62	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.07515056
63	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.06614290
64	P68_20966046_ChIP-Seq_HELA_Human	1.03173727
65	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.02695378
66	VDR_21846776_ChIP-Seq_THP-1_Human	1.02491063
67	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.02165265
68	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.01262766
69	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00312672
70	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.99042199
71	SA1_27219007_Chip-Seq_Bcells_Human	0.98777263
72	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.98772297
73	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.98736429
74	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.98025181
75	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.98023079
76	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.97909974
77	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.95042768
78	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.92803904
79	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.92763046
80	SMC4_20622854_ChIP-Seq_HELA_Human	0.92359496
81	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.91505906
82	MYC_22102868_ChIP-Seq_BL_Human	0.89992362
83	PHF8_20622854_ChIP-Seq_HELA_Human	0.89767928
84	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.89522281
85	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.88653514
86	ATF3_27146783_Chip-Seq_COLON_Human	0.88533925
87	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.88365602
88	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.88065146
89	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.87941522
90	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.86599676
91	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.85965314
92	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.85931326
93	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.85724232
94	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.85690237
95	BCL6_27268052_Chip-Seq_Bcells_Human	0.85176975
96	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.85121307
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.84945788
98	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.84733185
99	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.83657022
100	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.82286198

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.80845356
2	MP0005360_urolithiasis	7.68006805
3	MP0005365_abnormal_bile_salt	5.10580761
4	MP0005085_abnormal_gallbladder_physiolo	4.90419214
5	MP0001666_abnormal_nutrient_absorption	3.97221664
6	MP0005451_abnormal_body_composition	3.29279730
7	MP0003195_calcinosis	3.27506391
8	MP0008875_abnormal_xenobiotic_pharmacok	2.98421071
9	MP0009840_abnormal_foam_cell	2.94108788
10	MP0003868_abnormal_feces_composition	2.80885728
11	MP0010329_abnormal_lipoprotein_level	2.68163528
12	MP0002138_abnormal_hepatobiliary_system	2.60010065
13	MP0003252_abnormal_bile_duct	2.51494927
14	MP0003806_abnormal_nucleotide_metabolis	2.47776815
15	MP0004019_abnormal_vitamin_homeostasis	2.23061862
16	MP0010234_abnormal_vibrissa_follicle	2.19209854
17	MP0005332_abnormal_amino_acid	2.11239318
18	MP0004264_abnormal_extraembryonic_tissu	1.93086259
19	MP0005058_abnormal_lysosome_morphology	1.85010423
20	MP0000609_abnormal_liver_physiology	1.70552862
21	MP0001764_abnormal_homeostasis	1.66552875
22	MP0000566_synostosis	1.62988450
23	MP0009697_abnormal_copulation	1.54925477
24	MP0002118_abnormal_lipid_homeostasis	1.50086799
25	MP0003183_abnormal_peptide_metabolism	1.36792198
26	MP0002876_abnormal_thyroid_physiology	1.32681798
27	MP0005319_abnormal_enzyme/_coenzyme	1.32357904
28	MP0009643_abnormal_urine_homeostasis	1.29612961
29	MP0003718_maternal_effect	1.29053938
30	MP0003191_abnormal_cellular_cholesterol	1.28902965
31	MP0005636_abnormal_mineral_homeostasis	1.24431473
32	MP0002132_abnormal_respiratory_system	1.17232263
33	MP0005408_hypopigmentation	1.16337155
34	MP0002089_abnormal_postnatal_growth/wei	1.15026659
35	MP0009333_abnormal_splenocyte_physiolog	1.14353743
36	MP0010155_abnormal_intestine_physiology	1.09014023
37	MP0009379_abnormal_foot_pigmentation	1.07842117
38	MP0003172_abnormal_lysosome_physiology	1.03286359
39	MP0002796_impaired_skin_barrier	1.01050119
40	MP0005584_abnormal_enzyme/coenzyme_acti	1.00257193
41	MP0003693_abnormal_embryo_hatching	0.99982486
42	MP0008260_abnormal_autophagy	0.95941589
43	MP0000598_abnormal_liver_morphology	0.95870502
44	MP0003879_abnormal_hair_cell	0.93978371
45	MP0000477_abnormal_intestine_morphology	0.93496472
46	MP0005670_abnormal_white_adipose	0.92707267
47	MP0000604_amyloidosis	0.89108380
48	MP0005257_abnormal_intraocular_pressure	0.87552807
49	MP0009642_abnormal_blood_homeostasis	0.85548390
50	MP0010352_gastrointestinal_tract_polyps	0.85363459
51	MP0001915_intracranial_hemorrhage	0.82427682
52	MP0004957_abnormal_blastocyst_morpholog	0.80273073
53	MP0003866_abnormal_defecation	0.79468064
54	MP0000678_abnormal_parathyroid_gland	0.79164985
55	MP0008469_abnormal_protein_level	0.78073152
56	MP0004782_abnormal_surfactant_physiolog	0.77148977
57	MP0001730_embryonic_growth_arrest	0.76085488
58	MP0000490_abnormal_crypts_of	0.75684103
59	MP0003123_paternal_imprinting	0.73771328
60	MP0001765_abnormal_ion_homeostasis	0.72483789
61	MP0001756_abnormal_urination	0.70635003
62	MP0003186_abnormal_redox_activity	0.68876258
63	MP0005501_abnormal_skin_physiology	0.67456613
64	MP0002136_abnormal_kidney_physiology	0.67015848
65	MP0005395_other_phenotype	0.66450471
66	MP0005464_abnormal_platelet_physiology	0.65961143
67	MP0001664_abnormal_digestion	0.65743674
68	MP0002098_abnormal_vibrissa_morphology	0.65283531
69	MP0005166_decreased_susceptibility_to	0.63754968
70	MP0003453_abnormal_keratinocyte_physiol	0.63107034
71	MP0004858_abnormal_nervous_system	0.62636741
72	MP0003329_amyloid_beta_deposits	0.61419025
73	MP0009115_abnormal_fat_cell	0.61228851
74	MP0005023_abnormal_wound_healing	0.59704782
75	MP0005409_darkened_coat_color	0.59264536
76	MP0003567_abnormal_fetal_cardiomyocyte	0.58920499
77	MP0000858_altered_metastatic_potential	0.56725119
78	MP0005076_abnormal_cell_differentiation	0.53729582
79	MP0002971_abnormal_brown_adipose	0.53702357
80	MP0001663_abnormal_digestive_system	0.51588534
81	MP0002166_altered_tumor_susceptibility	0.49277668
82	MP0005376_homeostasis/metabolism_phenot	0.48102751
83	MP0001845_abnormal_inflammatory_respons	0.47767087
84	MP0005381_digestive/alimentary_phenotyp	0.46273336
85	MP0000462_abnormal_digestive_system	0.45868386
86	MP0003303_peritoneal_inflammation	0.45332468
87	MP0005377_hearing/vestibular/ear_phenot	0.44302847
88	MP0003878_abnormal_ear_physiology	0.44302847
89	MP0003638_abnormal_response/metabolism_	0.44155210
90	MP0003122_maternal_imprinting	0.44021084
91	MP0005666_abnormal_adipose_tissue	0.43496163
92	MP0001661_extended_life_span	0.43121766
93	MP0002086_abnormal_extraembryonic_tissu	0.42485099
94	MP0002078_abnormal_glucose_homeostasis	0.42413421
95	MP0004185_abnormal_adipocyte_glucose	0.42400549
96	MP0008004_abnormal_stomach_pH	0.42315022
97	MP0006036_abnormal_mitochondrial_physio	0.41291014
98	MP0001881_abnormal_mammary_gland	0.40874545
99	MP0003315_abnormal_perineum_morphology	0.39618637
100	MP0003436_decreased_susceptibility_to	0.39057746

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	8.26484243
2	Abnormality of monocarboxylic acid metabolism (HP:0010996)	7.36853234
3	Hypobetalipoproteinemia (HP:0003563)	6.31703479
4	Prolonged partial thromboplastin time (HP:0003645)	5.92517988
5	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.30543231
6	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.26774903
7	Complement deficiency (HP:0004431)	5.11787203
8	Systemic lupus erythematosus (HP:0002725)	5.06010240
9	Xanthomatosis (HP:0000991)	4.45780299
10	Abnormality of complement system (HP:0005339)	4.41268467
11	Abnormality of pyrimidine metabolism (HP:0004353)	4.25122291
12	Joint hemorrhage (HP:0005261)	4.22505298
13	Hemorrhage of the eye (HP:0011885)	4.19347431
14	Intrahepatic cholestasis (HP:0001406)	3.93858428
15	Glomerulonephritis (HP:0000099)	3.91064466
16	Conjugated hyperbilirubinemia (HP:0002908)	3.86590399
17	Hypolipoproteinemia (HP:0010981)	3.71401897
18	Hydroxyprolinuria (HP:0003080)	3.42446248
19	Abnormality of proline metabolism (HP:0010907)	3.42446248
20	Malnutrition (HP:0004395)	3.41262106
21	Fat malabsorption (HP:0002630)	3.37143761
22	Abnormality of the common coagulation pathway (HP:0010990)	3.19858355
23	Hyperammonemia (HP:0001987)	3.09798607
24	Hyperglycinuria (HP:0003108)	3.03910180
25	Abnormal tarsal ossification (HP:0008369)	2.94224641
26	Abnormality of serine family amino acid metabolism (HP:0010894)	2.89242626
27	Abnormality of glycine metabolism (HP:0010895)	2.89242626
28	Hypercholesterolemia (HP:0003124)	2.83743375
29	Widely patent fontanelles and sutures (HP:0004492)	2.81211077
30	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.78847331
31	Rickets (HP:0002748)	2.76626030
32	Abnormality of urine glucose concentration (HP:0011016)	2.72046958
33	Glycosuria (HP:0003076)	2.72046958
34	Hyperglycinemia (HP:0002154)	2.71237518
35	Generalized aminoaciduria (HP:0002909)	2.70974852
36	Reduced antithrombin III activity (HP:0001976)	2.64233426
37	Proximal tubulopathy (HP:0000114)	2.64032800
38	Abnormality of carpal bone ossification (HP:0006257)	2.62545424
39	Ileus (HP:0002595)	2.59532674
40	Hypophosphatemic rickets (HP:0004912)	2.58011456
41	Hyperphosphaturia (HP:0003109)	2.54819857
42	Abnormality of nucleobase metabolism (HP:0010932)	2.53974424
43	Flat acetabular roof (HP:0003180)	2.53044333
44	Hyperlipoproteinemia (HP:0010980)	2.49282990
45	Osteomalacia (HP:0002749)	2.49038980
46	Abnormal urine phosphate concentration (HP:0012599)	2.48157655
47	Nephritis (HP:0000123)	2.43784758
48	Spontaneous abortion (HP:0005268)	2.33697613
49	Acanthocytosis (HP:0001927)	2.29939495
50	Purpura (HP:0000979)	2.29433914
51	Vascular calcification (HP:0004934)	2.28509375
52	Hypophosphatemia (HP:0002148)	2.25869669
53	Steatorrhea (HP:0002570)	2.22882967
54	Cholecystitis (HP:0001082)	2.22585311
55	Abnormal gallbladder physiology (HP:0012438)	2.22585311
56	Increased serum pyruvate (HP:0003542)	2.21972812
57	Delayed epiphyseal ossification (HP:0002663)	2.16954428
58	Hypoalphalipoproteinemia (HP:0003233)	2.16038083
59	Wide cranial sutures (HP:0010537)	2.15708816
60	Abnormality of alkaline phosphatase activity (HP:0004379)	2.15334061
61	Abnormality of glycolysis (HP:0004366)	2.12858404
62	Abnormal enzyme/coenzyme activity (HP:0012379)	2.11782578
63	Abnormality of vitamin metabolism (HP:0100508)	2.11516032
64	Delayed CNS myelination (HP:0002188)	2.10518316
65	Nausea (HP:0002018)	2.08584582
66	Abnormality of the intrinsic pathway (HP:0010989)	2.06226492
67	Myocardial infarction (HP:0001658)	2.05377584
68	Elevated alkaline phosphatase (HP:0003155)	2.04584589
69	Hepatocellular carcinoma (HP:0001402)	2.03875071
70	Recurrent gram-negative bacterial infections (HP:0005420)	2.02883890
71	Alkalosis (HP:0001948)	2.01147593
72	Gingival bleeding (HP:0000225)	2.00679797
73	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.00211711
74	Abnormality of the Achilles tendon (HP:0005109)	1.99379106
75	Hypotension (HP:0002615)	1.96209602
76	Abnormality of serum amino acid levels (HP:0003112)	1.95123070
77	Paraparesis (HP:0002385)	1.93547351
78	Abnormal ossification of hand bones (HP:0005921)	1.93264777
79	Hypoglycemic coma (HP:0001325)	1.92045517
80	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91384091
81	Gout (HP:0001997)	1.89076221
82	Vaginal fistula (HP:0004320)	1.88950137
83	Menorrhagia (HP:0000132)	1.88257656
84	Cardiovascular calcification (HP:0011915)	1.87443172
85	Increased serum ferritin (HP:0003281)	1.87201550
86	Irritability (HP:0000737)	1.86622624
87	Metabolic acidosis (HP:0001942)	1.85172754
88	Epidermoid cyst (HP:0200040)	1.84125195
89	Vacuolated lymphocytes (HP:0001922)	1.82976994
90	Abnormal hand bone ossification (HP:0010660)	1.82484928
91	Renal tubular dysfunction (HP:0000124)	1.78728288
92	Abdominal distention (HP:0003270)	1.77312418
93	Abnormality of purine metabolism (HP:0004352)	1.75531651
94	Renal tubular acidosis (HP:0001947)	1.75142784
95	Thrombophlebitis (HP:0004418)	1.73556665
96	Abnormal foot bone ossification (HP:0010675)	1.72831175
97	Nephrolithiasis (HP:0000787)	1.71928153
98	Lower limb hyperreflexia (HP:0002395)	1.69732629
99	Abnormality of the lumbar spine (HP:0100712)	1.68849569
100	Pancreatitis (HP:0001733)	1.68292414

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR4	4.95068126
2	MST1R	4.50880576
3	LMTK2	3.79953616
4	ERN1	3.59064594
5	RIPK1	2.94548829
6	EPHA2	2.72672343
7	ICK	2.60801726
8	WNK4	2.58353161
9	IRAK3	2.47768646
10	SMG1	2.43274253
11	STK39	2.27450726
12	TRIB3	2.06901203
13	ACVR1B	2.00155315
14	PRPF4B	1.91569223
15	FGFR3	1.89448867
16	CDK12	1.87655809
17	SIK1	1.77889232
18	PRKG2	1.74161276
19	MET	1.71378964
20	NME1	1.63702188
21	TESK2	1.58726129
22	PBK	1.53159859
23	MAP3K1	1.52327985
24	MAP3K10	1.47066653
25	PIK3CA	1.36266097
26	MATK	1.34141762
27	MAPK11	1.31422066
28	STK24	1.24129356
29	TAOK2	1.22263855
30	NME2	1.19533870
31	EEF2K	1.18727840
32	TYRO3	1.15856347
33	KSR2	1.14382295
34	PAK4	1.14246673
35	MAP3K3	1.12504690
36	MAP3K8	1.12377776
37	DDR2	1.02541662
38	TYK2	0.96532024
39	PDPK1	0.92598842
40	MAP3K2	0.87041836
41	OXSR1	0.86074965
42	STK16	0.83219351
43	CDK7	0.81823471
44	PDK2	0.79263568
45	MAP3K9	0.78575460
46	FGR	0.77864044
47	BMX	0.77371226
48	PTK6	0.77348082
49	PDGFRA	0.76161117
50	CDC42BPA	0.75687720
51	MAP2K2	0.74656484
52	CDK6	0.74586306
53	LATS2	0.73935151
54	DYRK1B	0.73624652
55	EIF2AK1	0.73052114
56	TAOK1	0.72291383
57	MAP2K3	0.71500939
58	ERBB2	0.64220110
59	MAP3K6	0.63349782
60	CSF1R	0.62341268
61	PRKAA2	0.61829318
62	MAP3K12	0.61332382
63	MAP3K11	0.58508869
64	CDK4	0.56834402
65	CDK8	0.53874243
66	WNK1	0.53266969
67	MAP3K13	0.50502606
68	PDK1	0.49950892
69	MAP2K6	0.49222034
70	ZAP70	0.48971548
71	TTK	0.47807734
72	SCYL2	0.45627970
73	MAP4K1	0.44157140
74	GRK6	0.42818015
75	NEK1	0.42724109
76	RET	0.42441912
77	PKN2	0.41507635
78	FGFR1	0.39855196
79	MTOR	0.39349618
80	PRKACG	0.39217128
81	TBK1	0.38856445
82	NEK2	0.36925831
83	ARAF	0.36520239
84	EPHB2	0.35986758
85	TESK1	0.35049519
86	PTK2	0.34999376
87	MELK	0.32341286
88	AKT3	0.32315837
89	MAP3K5	0.31922560
90	CSNK2A2	0.29902033
91	AKT2	0.27422780
92	ALK	0.27006166
93	SRC	0.26811794
94	MAP3K14	0.25657138
95	CSNK2A1	0.25454399
96	RPS6KB1	0.25394847
97	MAPKAPK2	0.25263235
98	PHKG1	0.24031747
99	PHKG2	0.24031747
100	AURKB	0.23791318

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.55676846
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.23773278
3	Arginine biosynthesis_Homo sapiens_hsa00220	3.04016562
4	Complement and coagulation cascades_Homo sapiens_hsa04610	3.00209138
5	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.90720143
6	Caffeine metabolism_Homo sapiens_hsa00232	2.73631108
7	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.63309438
8	Retinol metabolism_Homo sapiens_hsa00830	2.54093353
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.53440117
10	Fat digestion and absorption_Homo sapiens_hsa04975	2.47228073
11	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.45687477
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.41661692
13	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.40527932
14	Chemical carcinogenesis_Homo sapiens_hsa05204	2.26138442
15	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.25006151
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.16501744
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.11175187
18	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.02279231
19	Fatty acid degradation_Homo sapiens_hsa00071	1.99519804
20	Phenylalanine metabolism_Homo sapiens_hsa00360	1.90457835
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.84269135
22	Bile secretion_Homo sapiens_hsa04976	1.83888951
23	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.83141506
24	Histidine metabolism_Homo sapiens_hsa00340	1.80669874
25	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.78980350
26	Sulfur metabolism_Homo sapiens_hsa00920	1.78967849
27	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.73425834
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.73082170
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.69899975
30	Arginine and proline metabolism_Homo sapiens_hsa00330	1.67204562
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.59488170
32	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.55573889
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.54403618
34	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.51655971
35	Galactose metabolism_Homo sapiens_hsa00052	1.41085531
36	Renin-angiotensin system_Homo sapiens_hsa04614	1.40570114
37	Other glycan degradation_Homo sapiens_hsa00511	1.37282236
38	Folate biosynthesis_Homo sapiens_hsa00790	1.35663349
39	Carbon metabolism_Homo sapiens_hsa01200	1.30890051
40	Tyrosine metabolism_Homo sapiens_hsa00350	1.30168611
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.27334103
42	Pyruvate metabolism_Homo sapiens_hsa00620	1.26920135
43	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.24369128
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.20178436
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.11569347
46	Fatty acid metabolism_Homo sapiens_hsa01212	1.10483094
47	Peroxisome_Homo sapiens_hsa04146	1.10427311
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.09584514
49	Mineral absorption_Homo sapiens_hsa04978	1.05187854
50	Linoleic acid metabolism_Homo sapiens_hsa00591	1.04991673
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98806950
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97603598
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96736850
54	Sulfur relay system_Homo sapiens_hsa04122	0.89720200
55	Butanoate metabolism_Homo sapiens_hsa00650	0.88807572
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88568659
57	Pentose phosphate pathway_Homo sapiens_hsa00030	0.82798473
58	Glutathione metabolism_Homo sapiens_hsa00480	0.80460973
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.72708024
60	Fatty acid elongation_Homo sapiens_hsa00062	0.72065571
61	One carbon pool by folate_Homo sapiens_hsa00670	0.67857689
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65001282
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64610463
64	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.64090740
65	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.62264907
66	Propanoate metabolism_Homo sapiens_hsa00640	0.60707058
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55950784
68	Metabolic pathways_Homo sapiens_hsa01100	0.53711662
69	Prion diseases_Homo sapiens_hsa05020	0.49156172
70	ABC transporters_Homo sapiens_hsa02010	0.45586083
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44457698
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.38706400
73	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37129083
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36982120
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.36461167
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.35666053
77	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.33718018
78	Lysine degradation_Homo sapiens_hsa00310	0.32313168
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32243583
80	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.26959819
81	Insulin resistance_Homo sapiens_hsa04931	0.25344404
82	Pertussis_Homo sapiens_hsa05133	0.23859516
83	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.22865426
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.22075745
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.19911488
86	Ribosome_Homo sapiens_hsa03010	0.19581049
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.13185901
88	Glucagon signaling pathway_Homo sapiens_hsa04922	0.12646935
89	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.11456516
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.11339927
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.10664861
92	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.07092941
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.05927098
94	Base excision repair_Homo sapiens_hsa03410	0.02929048
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.00827095
96	Ether lipid metabolism_Homo sapiens_hsa00565	-0.0357626
97	Nitrogen metabolism_Homo sapiens_hsa00910	-0.0258179
98	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.0191461
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	-0.0155707
100	Adipocytokine signaling pathway_Homo sapiens_hsa04920	-0.0057389

ZNF511-PRAP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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