ZNF516

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)4.26727895
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26727895
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26727895
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.26727895
5modulation by symbiont of host immune response (GO:0052553)4.26727895
6positive regulation by symbiont of host defense response (GO:0052509)4.26727895
7detection of molecule of bacterial origin (GO:0032490)4.03901746
8cellular extravasation (GO:0045123)4.02599462
9response to peptidoglycan (GO:0032494)3.86539688
10macrophage activation involved in immune response (GO:0002281)3.60146249
11leukocyte migration involved in inflammatory response (GO:0002523)3.59718655
12neutrophil mediated immunity (GO:0002446)3.43425038
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41560772
14detection of other organism (GO:0098543)3.40705765
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.29883446
16microglial cell activation (GO:0001774)3.28741579
17negative regulation of interleukin-1 production (GO:0032692)3.28449568
18detection of external biotic stimulus (GO:0098581)3.27942414
19negative regulation of cAMP-mediated signaling (GO:0043951)3.19346148
20neutrophil activation involved in immune response (GO:0002283)3.15692671
21detection of biotic stimulus (GO:0009595)3.14849361
22auditory receptor cell differentiation (GO:0042491)3.13437328
23negative regulation of interleukin-1 beta production (GO:0032691)3.07086046
24macrophage activation (GO:0042116)3.07070223
25negative regulation of alpha-beta T cell differentiation (GO:0046639)3.00200903
26detection of bacterium (GO:0016045)2.97384422
27response to host immune response (GO:0052572)2.88338857
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88338857
29negative regulation of glial cell proliferation (GO:0060253)2.86453534
30negative regulation of interleukin-12 production (GO:0032695)2.82390031
31respiratory burst (GO:0045730)2.75499388
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71953564
33response to host (GO:0075136)2.71953564
34response to host defenses (GO:0052200)2.71953564
35positive regulation of gamma-delta T cell activation (GO:0046645)2.71894195
36negative regulation of cell killing (GO:0031342)2.70845234
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70845234
38neuronal stem cell maintenance (GO:0097150)2.69891488
39neuron fate determination (GO:0048664)2.68750615
40limb bud formation (GO:0060174)2.67428174
41myeloid leukocyte mediated immunity (GO:0002444)2.67379881
42regulation of interleukin-6 biosynthetic process (GO:0045408)2.65066193
43response to muramyl dipeptide (GO:0032495)2.64645356
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64618861
45positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64534486
46regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63206775
47neutrophil activation (GO:0042119)2.63102905
48positive regulation of mast cell activation (GO:0033005)2.57364946
49positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56257163
50olfactory bulb development (GO:0021772)2.54812861
51regulation of interferon-beta biosynthetic process (GO:0045357)2.52871634
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.49730523
53establishment of nucleus localization (GO:0040023)2.45786401
54negative regulation of axon guidance (GO:1902668)2.43228161
55negative regulation of alpha-beta T cell activation (GO:0046636)2.42797285
56negative regulation of interleukin-6 production (GO:0032715)2.42122053
57negative regulation of lymphocyte mediated immunity (GO:0002707)2.41135641
58activated T cell proliferation (GO:0050798)2.40872441
59neural tube formation (GO:0001841)2.40670090
60establishment of protein localization to Golgi (GO:0072600)2.40299968
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39961732
62epithelial cell fate commitment (GO:0072148)2.33849268
63regulation of mast cell activation (GO:0033003)2.33202099
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.32748780
65negative regulation of T-helper cell differentiation (GO:0045623)2.32748780
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.26708539
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.26708539
68regulation of translation, ncRNA-mediated (GO:0045974)2.26708539
69cilium movement (GO:0003341)2.26504323
70production of molecular mediator involved in inflammatory response (GO:0002532)2.25821786
71kidney morphogenesis (GO:0060993)2.25704428
72protein targeting to Golgi (GO:0000042)2.25596065
73regulation of gamma-delta T cell activation (GO:0046643)2.24702875
74dendritic spine morphogenesis (GO:0060997)2.24309189
75histone H3-K4 trimethylation (GO:0080182)2.21628354
76regulation of mast cell degranulation (GO:0043304)2.21251987
77negative regulation of Rho protein signal transduction (GO:0035024)2.20978999
78regulation of B cell receptor signaling pathway (GO:0050855)2.20954882
79granulocyte activation (GO:0036230)2.20873901
80epithelial cilium movement (GO:0003351)2.20390399
81radial glial cell differentiation (GO:0060019)2.18978413
82neutrophil chemotaxis (GO:0030593)2.18726745
83regulation of cilium movement (GO:0003352)2.18721814
84somite development (GO:0061053)2.17303094
85axonemal dynein complex assembly (GO:0070286)2.16876467
86prostate gland growth (GO:0060736)2.15635588
87positive regulation of mast cell activation involved in immune response (GO:0033008)2.15587316
88positive regulation of mast cell degranulation (GO:0043306)2.15587316
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.15581927
90regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.15510751
91regulation of mast cell activation involved in immune response (GO:0033006)2.14997081
92myelin assembly (GO:0032288)2.14215633
93endocrine pancreas development (GO:0031018)2.14212260
94hindbrain development (GO:0030902)2.12945034
95neutrophil migration (GO:1990266)2.12736611
96myeloid cell activation involved in immune response (GO:0002275)2.11443476
97germinal center formation (GO:0002467)2.11420230
98pericardium development (GO:0060039)2.11131158
99regulation of somitogenesis (GO:0014807)2.11097749
100regulation of leukocyte degranulation (GO:0043300)2.10853737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.78877470
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20858426
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95709242
4CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84542060
5* VDR_24787735_ChIP-Seq_THP-1_Human1.76173226
6SMAD_19615063_ChIP-ChIP_OVARY_Human1.75327215
7IRF8_22096565_ChIP-ChIP_GC-B_Human1.70066588
8IRF8_27001747_Chip-Seq_BMDM_Mouse1.68597379
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63278531
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58796772
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56339955
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52771126
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52771126
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50151840
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.50064006
16GBX2_23144817_ChIP-Seq_PC3_Human1.50055107
17IRF8_21731497_ChIP-ChIP_J774_Mouse1.45262527
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44956132
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44739807
20DROSHA_22980978_ChIP-Seq_HELA_Human1.40828811
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.40621735
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39613803
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39010780
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37222703
25TP53_16413492_ChIP-PET_HCT116_Human1.35450003
26SPI1_23127762_ChIP-Seq_K562_Human1.34026416
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32949563
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32020417
29WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28930247
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28632366
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27730285
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26479314
33BCAT_22108803_ChIP-Seq_LS180_Human1.23184318
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22673573
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22665018
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22158731
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.21155911
38ZNF274_21170338_ChIP-Seq_K562_Hela1.20278772
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18886205
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18529906
41* VDR_24763502_ChIP-Seq_THP-1_Human1.17687926
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.15580786
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.10188293
44SMAD4_21799915_ChIP-Seq_A2780_Human1.09810534
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09740523
46RUNX_20019798_ChIP-Seq_JUKART_Human1.08998250
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08991469
48AHR_22903824_ChIP-Seq_MCF-7_Human1.05577271
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05566914
50* ARNT_22903824_ChIP-Seq_MCF-7_Human1.04802796
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03803010
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02747015
53* SMAD3_21741376_ChIP-Seq_HESCs_Human1.02475752
54ER_23166858_ChIP-Seq_MCF-7_Human1.02431773
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02304271
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.02192233
57STAT3_23295773_ChIP-Seq_U87_Human1.02153660
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01901579
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01222592
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.00951240
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00910747
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00779546
63RXR_22108803_ChIP-Seq_LS180_Human0.99947933
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99253133
65NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99253133
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98459556
67* RUNX2_22187159_ChIP-Seq_PCA_Human0.97431591
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97296561
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96734506
70SALL1_21062744_ChIP-ChIP_HESCs_Human0.96296222
71NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96063533
72* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95812318
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95287209
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95127304
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94579849
76* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93418562
77JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93191329
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92389838
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92238524
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92221881
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91661333
82* P300_19829295_ChIP-Seq_ESCs_Human0.91576928
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91397037
84TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91327337
85RING1B_27294783_Chip-Seq_ESCs_Mouse0.90966616
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90857426
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90787552
88P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90636119
89* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90521732
90EED_16625203_ChIP-ChIP_MESCs_Mouse0.90456691
91KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90280255
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89704957
93* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89511443
94REST_21632747_ChIP-Seq_MESCs_Mouse0.89285484
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89229794
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89073357
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89057425
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88723638
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.88355981
100SMRT_27268052_Chip-Seq_Bcells_Human0.87888474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.95552899
2MP0003724_increased_susceptibility_to3.52620206
3MP0003172_abnormal_lysosome_physiology3.19892191
4MP0003303_peritoneal_inflammation3.13356887
5MP0003122_maternal_imprinting2.90621022
6MP0003283_abnormal_digestive_organ2.74106692
7MP0005248_abnormal_Harderian_gland2.42492040
8MP0003787_abnormal_imprinting2.36993729
9MP0002653_abnormal_ependyma_morphology2.17806608
10MP0006292_abnormal_olfactory_placode2.15884949
11MP0002928_abnormal_bile_duct2.14901042
12MP0002102_abnormal_ear_morphology2.08576476
13MP0009278_abnormal_bone_marrow2.06628016
14MP0008004_abnormal_stomach_pH1.99671628
15MP0000015_abnormal_ear_pigmentation1.98810884
16MP0003436_decreased_susceptibility_to1.81920961
17MP0003195_calcinosis1.81502177
18MP0002419_abnormal_innate_immunity1.77923506
19MP0002837_dystrophic_cardiac_calcinosis1.77351605
20MP0001986_abnormal_taste_sensitivity1.69855082
21MP0003878_abnormal_ear_physiology1.62179980
22MP0005377_hearing/vestibular/ear_phenot1.62179980
23MP0003121_genomic_imprinting1.56849583
24MP0002254_reproductive_system_inflammat1.53699885
25MP0004883_abnormal_blood_vessel1.46360107
26MP0006054_spinal_hemorrhage1.44313190
27MP0003828_pulmonary_edema1.43271447
28MP0009053_abnormal_anal_canal1.39831198
29MP0005220_abnormal_exocrine_pancreas1.38864459
30MP0005174_abnormal_tail_pigmentation1.37296438
31MP0004133_heterotaxia1.35523720
32MP0001293_anophthalmia1.33149486
33MP0005367_renal/urinary_system_phenotyp1.29620098
34MP0000516_abnormal_urinary_system1.29620098
35MP0001984_abnormal_olfaction1.25177440
36MP0005397_hematopoietic_system_phenotyp1.25099018
37MP0001545_abnormal_hematopoietic_system1.25099018
38MP0000778_abnormal_nervous_system1.21701058
39MP0008260_abnormal_autophagy1.20106183
40MP0003938_abnormal_ear_development1.18747204
41MP0001835_abnormal_antigen_presentation1.17915066
42MP0001533_abnormal_skeleton_physiology1.16572290
43MP0006082_CNS_inflammation1.14823034
44MP0000631_abnormal_neuroendocrine_gland1.14772834
45MP0000685_abnormal_immune_system1.14567896
46MP0000383_abnormal_hair_follicle1.13973242
47MP0000428_abnormal_craniofacial_morphol1.13311162
48MP0005409_darkened_coat_color1.12077590
49MP0009764_decreased_sensitivity_to1.08804356
50MP0000470_abnormal_stomach_morphology1.07757756
51MP0002277_abnormal_respiratory_mucosa1.07039410
52MP0005075_abnormal_melanosome_morpholog1.05603658
53MP0005499_abnormal_olfactory_system1.04732045
54MP0005394_taste/olfaction_phenotype1.04732045
55MP0002909_abnormal_adrenal_gland1.04367094
56MP0000427_abnormal_hair_cycle1.03602237
57MP0005025_abnormal_response_to1.01677427
58MP0001958_emphysema1.00903714
59MP0004381_abnormal_hair_follicle1.00525866
60MP0002092_abnormal_eye_morphology0.99408856
61MP0003890_abnormal_embryonic-extraembry0.99382711
62MP0000566_synostosis0.96364127
63MP0001944_abnormal_pancreas_morphology0.96001185
64MP0002282_abnormal_trachea_morphology0.95843247
65MP0001324_abnormal_eye_pigmentation0.94331948
66MP0003943_abnormal_hepatobiliary_system0.92400805
67MP0003300_gastrointestinal_ulcer0.92169420
68MP0002405_respiratory_system_inflammati0.91876849
69MP0003183_abnormal_peptide_metabolism0.90539140
70MP0005076_abnormal_cell_differentiation0.90433720
71MP0004130_abnormal_muscle_cell0.87655408
72MP0002168_other_aberrant_phenotype0.87345883
73MP0001800_abnormal_humoral_immune0.86608078
74MP0005645_abnormal_hypothalamus_physiol0.86135067
75MP0008789_abnormal_olfactory_epithelium0.85573106
76MP0000767_abnormal_smooth_muscle0.85364516
77MP0002132_abnormal_respiratory_system0.84833887
78MP0002233_abnormal_nose_morphology0.83981651
79MP0002998_abnormal_bone_remodeling0.82048278
80MP0002693_abnormal_pancreas_physiology0.80603077
81MP0008961_abnormal_basal_metabolism0.79041778
82MP0005464_abnormal_platelet_physiology0.78027161
83MP0002127_abnormal_cardiovascular_syste0.76969181
84MP0002723_abnormal_immune_serum0.76015149
85MP0005164_abnormal_response_to0.75477040
86MP0003119_abnormal_digestive_system0.75399858
87MP0010678_abnormal_skin_adnexa0.74658464
88MP0008877_abnormal_DNA_methylation0.74538863
89MP0002249_abnormal_larynx_morphology0.74456318
90MP0005084_abnormal_gallbladder_morpholo0.74124644
91MP0005387_immune_system_phenotype0.73414380
92MP0001790_abnormal_immune_system0.73414380
93MP0002751_abnormal_autonomic_nervous0.73019491
94MP0003115_abnormal_respiratory_system0.72028177
95MP0002452_abnormal_antigen_presenting0.71788073
96MP0002420_abnormal_adaptive_immunity0.70865284
97MP0005381_digestive/alimentary_phenotyp0.70822685
98MP0001175_abnormal_lung_morphology0.69253432
99MP0005390_skeleton_phenotype0.68298722
100MP0005391_vision/eye_phenotype0.68247547

Predicted human phenotypes

RankGene SetZ-score
1Peritonitis (HP:0002586)5.45871789
2Elevated erythrocyte sedimentation rate (HP:0003565)4.96821854
3Recurrent gram-negative bacterial infections (HP:0005420)3.50858995
4Recurrent bacterial skin infections (HP:0005406)3.15287184
5Recurrent abscess formation (HP:0002722)3.09777902
6Myositis (HP:0100614)3.01371168
7Progressive cerebellar ataxia (HP:0002073)2.97989494
8Orchitis (HP:0100796)2.97748971
9Optic neuritis (HP:0100653)2.95582873
10Retrobulbar optic neuritis (HP:0100654)2.95582873
11Gastrointestinal infarctions (HP:0005244)2.94134764
12Dynein arm defect of respiratory motile cilia (HP:0012255)2.90149339
13Absent/shortened dynein arms (HP:0200106)2.90149339
14Eczematoid dermatitis (HP:0000976)2.78868717
15Stomatitis (HP:0010280)2.70208175
16Intestinal atresia (HP:0011100)2.60822687
17Hematochezia (HP:0002573)2.58782849
18Pancreatic fibrosis (HP:0100732)2.58281753
19Aqueductal stenosis (HP:0002410)2.46990251
20Hip dysplasia (HP:0001385)2.43658686
21Abnormality of macrophages (HP:0004311)2.43634766
22Abnormality of the peritoneum (HP:0002585)2.43414135
23Abnormal respiratory epithelium morphology (HP:0012253)2.38727520
24Abnormal respiratory motile cilium morphology (HP:0005938)2.38727520
25Recurrent cutaneous fungal infections (HP:0011370)2.37585980
26Chronic mucocutaneous candidiasis (HP:0002728)2.37585980
27Hepatoblastoma (HP:0002884)2.35854583
28Chronic hepatic failure (HP:0100626)2.35381447
29Agitation (HP:0000713)2.34915430
30Short 4th metacarpal (HP:0010044)2.32161702
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32161702
32Nephronophthisis (HP:0000090)2.30242682
33Episodic fever (HP:0001954)2.29840243
34Pancreatic cysts (HP:0001737)2.28496846
35Abnormal ciliary motility (HP:0012262)2.24735991
36Abnormality of the aortic arch (HP:0012303)2.24507249
37Disproportionate short-trunk short stature (HP:0003521)2.23699532
38Amyloidosis (HP:0011034)2.23626695
39True hermaphroditism (HP:0010459)2.22107447
40Hypochromic anemia (HP:0001931)2.21527086
41Vitreoretinal degeneration (HP:0000655)2.18952887
42Abnormality of the renal medulla (HP:0100957)2.14918158
43Hypochromic microcytic anemia (HP:0004840)2.14778378
44Hypoplastic ischia (HP:0003175)2.08800505
45Recurrent skin infections (HP:0001581)2.07994605
46Cystic liver disease (HP:0006706)2.07808388
47Oligodactyly (hands) (HP:0001180)2.05207917
48Anophthalmia (HP:0000528)2.05158321
49Abnormal hair whorl (HP:0010721)2.03736531
50Shawl scrotum (HP:0000049)2.01628914
51Abnormal pancreas size (HP:0012094)2.01598074
52Spontaneous hematomas (HP:0007420)2.00846157
53Gingivitis (HP:0000230)1.98052883
54Abnormality of the ischium (HP:0003174)1.96985431
55Abnormal respiratory motile cilium physiology (HP:0012261)1.96305466
56Keratoconjunctivitis (HP:0001096)1.94830024
57Keratoconjunctivitis sicca (HP:0001097)1.94429963
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94412230
59Difficulty running (HP:0009046)1.93258867
60Gingival bleeding (HP:0000225)1.90881414
61Tubulointerstitial nephritis (HP:0001970)1.88708426
62Hemoptysis (HP:0002105)1.87880294
63Preaxial foot polydactyly (HP:0001841)1.87873834
64Truncal obesity (HP:0001956)1.87630825
65Leukocytosis (HP:0001974)1.85976879
66Albinism (HP:0001022)1.85808261
67Recurrent fungal infections (HP:0002841)1.82767797
68Abnormality of the intervertebral disk (HP:0005108)1.82181370
69Urticaria (HP:0001025)1.81145557
70Widely spaced teeth (HP:0000687)1.77697307
71Genetic anticipation (HP:0003743)1.77122846
72Neoplasm of the heart (HP:0100544)1.76290916
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75862456
74Abnormal delayed hypersensitivity skin test (HP:0002963)1.75362244
75Chest pain (HP:0100749)1.74545668
76Hypoplastic iliac wings (HP:0002866)1.72467839
77Postaxial foot polydactyly (HP:0001830)1.70793797
78Medial flaring of the eyebrow (HP:0010747)1.70197986
79Broad toe (HP:0001837)1.69533496
80Down-sloping shoulders (HP:0200021)1.69260866
81Abnormality of the fingertips (HP:0001211)1.64550666
82Abnormality of the 4th metacarpal (HP:0010012)1.64462743
83Postaxial hand polydactyly (HP:0001162)1.63154685
84Growth hormone deficiency (HP:0000824)1.62278471
85Rhinitis (HP:0012384)1.62277293
86Tented upper lip vermilion (HP:0010804)1.59912971
87Broad hallux (HP:0010055)1.59441373
88Wide anterior fontanel (HP:0000260)1.59056507
89Midline defect of the nose (HP:0004122)1.58679745
90Mediastinal lymphadenopathy (HP:0100721)1.58091635
91Papillary thyroid carcinoma (HP:0002895)1.57510487
92Downturned corners of mouth (HP:0002714)1.56907368
93Vasculitis (HP:0002633)1.55345626
94Testicular neoplasm (HP:0010788)1.54649109
95High anterior hairline (HP:0009890)1.54622885
96Hypoplasia of the maxilla (HP:0000327)1.54508749
97Exotropia (HP:0000577)1.54428370
98Thickened calvaria (HP:0002684)1.54149339
99Congenital hepatic fibrosis (HP:0002612)1.53875162
100Abnormality of incisor morphology (HP:0011063)1.53128747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.41427822
2FGFR22.31483998
3BLK2.13378812
4IRAK41.98590831
5FES1.89835574
6TNK21.83604986
7EPHB21.81262149
8BMPR1B1.81046146
9MAP2K31.79301363
10WNK31.75017924
11STK111.71711371
12TYK21.66627668
13CSK1.56142791
14MARK21.56023244
15MAP2K41.55780431
16MAP3K71.55417518
17FGFR31.51680644
18RIPK41.45848816
19PRKD21.43239601
20SGK21.32001493
21YES11.31149569
22KIT1.28173622
23MAPK151.26045654
24HCK1.20341378
25INSRR1.18822517
26IRAK11.16494599
27MAP3K41.15738007
28CAMK1G1.11061799
29CSF1R1.10443686
30BTK1.10139439
31FGR1.08004268
32NLK1.04334976
33ACVR1B1.03330451
34MAP3K21.01955768
35PIK3CG1.00474565
36PAK30.98850362
37BRD40.98212258
38DYRK1B0.97828158
39CAMK1D0.93609614
40SGK30.93168519
41MAP3K60.93056743
42AKT30.91303807
43TNIK0.91180659
44RPS6KA20.91158714
45WNK10.90509436
46ADRBK20.89367157
47PTK2B0.89149781
48PKN20.88886210
49EPHB10.88736228
50RPS6KC10.88358489
51RPS6KL10.88358489
52RPS6KA60.87726598
53LYN0.85246939
54MAPK70.83701644
55PINK10.82156434
56TAOK10.82151111
57IKBKE0.81373490
58MAP4K10.80965679
59SGK4940.79883017
60SGK2230.79883017
61DMPK0.78395594
62CHUK0.77321510
63CAMK40.76800894
64GRK60.75746165
65ZAP700.74455893
66KSR10.74328509
67TGFBR20.74118194
68NTRK20.73683944
69GRK10.73579563
70PRKAA20.71274334
71MARK30.69162669
72CDK190.69063710
73JAK10.67654521
74SYK0.67382874
75TEC0.67151688
76DYRK30.66401557
77SIK20.65906315
78JAK20.65427336
79PRKCZ0.65082007
80IRAK20.64800592
81SIK10.62065867
82ERBB20.60089188
83LCK0.59713273
84TAOK30.58719828
85MAP4K20.58312745
86MATK0.56118508
87RET0.55397758
88PKN10.55333632
89EPHA30.55293421
90MAP3K110.54586755
91CDC42BPA0.53630784
92HIPK20.53399556
93MAP3K30.52792097
94SIK30.52382526
95MAPK130.50966951
96PDGFRB0.50641883
97GRK70.49875055
98CASK0.49322384
99ADRBK10.48894072
100PRKAA10.48575993

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.22042677
2Osteoclast differentiation_Homo sapiens_hsa043802.05832536
3Notch signaling pathway_Homo sapiens_hsa043301.76464647
4Staphylococcus aureus infection_Homo sapiens_hsa051501.70017260
5Type II diabetes mellitus_Homo sapiens_hsa049301.65552353
6Leishmaniasis_Homo sapiens_hsa051401.64930122
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59436379
8Hedgehog signaling pathway_Homo sapiens_hsa043401.54065968
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52981965
10Dorso-ventral axis formation_Homo sapiens_hsa043201.44497820
11Tuberculosis_Homo sapiens_hsa051521.43862644
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43200266
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35547871
14Basal cell carcinoma_Homo sapiens_hsa052171.33311037
15Other glycan degradation_Homo sapiens_hsa005111.32075499
16mTOR signaling pathway_Homo sapiens_hsa041501.30722844
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30258969
18B cell receptor signaling pathway_Homo sapiens_hsa046621.29488526
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24852154
20Regulation of autophagy_Homo sapiens_hsa041401.21095172
21Malaria_Homo sapiens_hsa051441.19758600
22FoxO signaling pathway_Homo sapiens_hsa040681.15175828
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15048561
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14402535
25Prolactin signaling pathway_Homo sapiens_hsa049171.09692283
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09679330
27Endometrial cancer_Homo sapiens_hsa052131.04433657
28Chemokine signaling pathway_Homo sapiens_hsa040621.04415745
29Acute myeloid leukemia_Homo sapiens_hsa052211.03969604
30Colorectal cancer_Homo sapiens_hsa052101.03944274
31Platelet activation_Homo sapiens_hsa046111.03322901
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02936797
33Jak-STAT signaling pathway_Homo sapiens_hsa046300.99942540
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99730704
35Choline metabolism in cancer_Homo sapiens_hsa052310.98713851
36Glycosaminoglycan degradation_Homo sapiens_hsa005310.98131756
37Phospholipase D signaling pathway_Homo sapiens_hsa040720.96833921
38Neurotrophin signaling pathway_Homo sapiens_hsa047220.96449196
39Axon guidance_Homo sapiens_hsa043600.94157682
40Phagosome_Homo sapiens_hsa041450.92822049
41Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92126126
42Legionellosis_Homo sapiens_hsa051340.89628235
43Renal cell carcinoma_Homo sapiens_hsa052110.88033780
44Inositol phosphate metabolism_Homo sapiens_hsa005620.87536048
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85165542
46Insulin resistance_Homo sapiens_hsa049310.83584581
47Non-small cell lung cancer_Homo sapiens_hsa052230.82570009
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82563585
49Lysosome_Homo sapiens_hsa041420.81886109
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.81027170
51TNF signaling pathway_Homo sapiens_hsa046680.80344064
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80058357
53Toxoplasmosis_Homo sapiens_hsa051450.78664644
54Amoebiasis_Homo sapiens_hsa051460.78422096
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.77934234
56Rap1 signaling pathway_Homo sapiens_hsa040150.73948411
57Influenza A_Homo sapiens_hsa051640.73669891
58VEGF signaling pathway_Homo sapiens_hsa043700.73010581
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72966800
60cAMP signaling pathway_Homo sapiens_hsa040240.72815203
61GnRH signaling pathway_Homo sapiens_hsa049120.72709962
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72692426
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72602861
64Long-term depression_Homo sapiens_hsa047300.68741475
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68607379
66Hepatitis C_Homo sapiens_hsa051600.67825539
67Hepatitis B_Homo sapiens_hsa051610.67543739
68Insulin secretion_Homo sapiens_hsa049110.67267046
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66982902
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66563688
71Measles_Homo sapiens_hsa051620.65735262
72MAPK signaling pathway_Homo sapiens_hsa040100.65014236
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64883596
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64725470
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63761055
76African trypanosomiasis_Homo sapiens_hsa051430.63680824
77Cholinergic synapse_Homo sapiens_hsa047250.63633104
78Oxytocin signaling pathway_Homo sapiens_hsa049210.63202973
79Pertussis_Homo sapiens_hsa051330.62550741
80ErbB signaling pathway_Homo sapiens_hsa040120.62340396
81Pancreatic cancer_Homo sapiens_hsa052120.61602968
82T cell receptor signaling pathway_Homo sapiens_hsa046600.61552313
83Lysine degradation_Homo sapiens_hsa003100.61163993
84Prostate cancer_Homo sapiens_hsa052150.60975345
85Chronic myeloid leukemia_Homo sapiens_hsa052200.60802030
86Phototransduction_Homo sapiens_hsa047440.60264218
87Complement and coagulation cascades_Homo sapiens_hsa046100.60116160
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59493690
89Type I diabetes mellitus_Homo sapiens_hsa049400.59299851
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.59167760
91Estrogen signaling pathway_Homo sapiens_hsa049150.58870519
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58364351
93Insulin signaling pathway_Homo sapiens_hsa049100.57968021
94Cocaine addiction_Homo sapiens_hsa050300.57638996
95Wnt signaling pathway_Homo sapiens_hsa043100.55974438
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55622915
97AMPK signaling pathway_Homo sapiens_hsa041520.54387843
98Circadian entrainment_Homo sapiens_hsa047130.54302370
99Melanogenesis_Homo sapiens_hsa049160.54217347
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53813029

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