ZNF517

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.97126924
2behavioral response to nicotine (GO:0035095)4.37963783
3nucleobase catabolic process (GO:0046113)4.05192984
4neurotransmitter-gated ion channel clustering (GO:0072578)3.93259831
5axoneme assembly (GO:0035082)3.63966324
6nonmotile primary cilium assembly (GO:0035058)3.63111981
7water-soluble vitamin biosynthetic process (GO:0042364)3.57956265
8nephron tubule morphogenesis (GO:0072078)3.48776778
9nephron epithelium morphogenesis (GO:0072088)3.48776778
10postsynaptic membrane organization (GO:0001941)3.37321096
11intestinal cholesterol absorption (GO:0030299)3.29729041
12secondary heart field specification (GO:0003139)3.28978150
13heart field specification (GO:0003128)3.28978150
14snRNA transcription (GO:0009301)3.14375737
15negative regulation of sodium ion transport (GO:0010766)3.13202231
16opioid receptor signaling pathway (GO:0038003)3.12159359
17C4-dicarboxylate transport (GO:0015740)3.01546661
18body morphogenesis (GO:0010171)3.00718750
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00231577
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.97029366
21neuromuscular process controlling posture (GO:0050884)2.95519426
22cellular anion homeostasis (GO:0030002)2.91520810
23presynaptic membrane organization (GO:0097090)2.87225522
24synaptic transmission, cholinergic (GO:0007271)2.86651316
25startle response (GO:0001964)2.85496985
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83942892
27positive regulation of dendritic spine morphogenesis (GO:0061003)2.80947714
28positive regulation of CREB transcription factor activity (GO:0032793)2.80827469
29regulation of triglyceride biosynthetic process (GO:0010866)2.79075284
30peristalsis (GO:0030432)2.78545347
31regulation of male gonad development (GO:2000018)2.78496593
32neuronal action potential propagation (GO:0019227)2.75409628
33regulation of synapse maturation (GO:0090128)2.75085516
34gamma-aminobutyric acid transport (GO:0015812)2.74343970
35protein localization to cilium (GO:0061512)2.73925608
36regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72643757
37high-density lipoprotein particle remodeling (GO:0034375)2.72025661
38negative regulation of macroautophagy (GO:0016242)2.71274297
39reverse cholesterol transport (GO:0043691)2.71081846
40specification of organ identity (GO:0010092)2.70408093
41neuromuscular synaptic transmission (GO:0007274)2.69673843
42presynaptic membrane assembly (GO:0097105)2.69200525
43phosphatidylinositol 3-kinase signaling (GO:0014065)2.69199103
44positive regulation of synapse maturation (GO:0090129)2.68145475
45detection of light stimulus involved in visual perception (GO:0050908)2.67958145
46detection of light stimulus involved in sensory perception (GO:0050962)2.67958145
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.67620464
48sulfate transmembrane transport (GO:1902358)2.67445743
49iron-sulfur cluster assembly (GO:0016226)2.66306224
50metallo-sulfur cluster assembly (GO:0031163)2.66306224
51renal tubule morphogenesis (GO:0061333)2.65001375
52cell migration in hindbrain (GO:0021535)2.63785062
53protein carboxylation (GO:0018214)2.63334870
54peptidyl-glutamic acid carboxylation (GO:0017187)2.63334870
55mechanosensory behavior (GO:0007638)2.62155629
56neuronal action potential (GO:0019228)2.61362624
57activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.60921581
58protein polyglutamylation (GO:0018095)2.60669155
59negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57701330
60regulation of timing of cell differentiation (GO:0048505)2.56521328
61fucose catabolic process (GO:0019317)2.56079775
62L-fucose metabolic process (GO:0042354)2.56079775
63L-fucose catabolic process (GO:0042355)2.56079775
64plasma lipoprotein particle remodeling (GO:0034369)2.54742848
65protein-lipid complex remodeling (GO:0034368)2.54742848
66macromolecular complex remodeling (GO:0034367)2.54742848
67cellular response to ATP (GO:0071318)2.52465784
68auditory behavior (GO:0031223)2.51675330
69protein localization to synapse (GO:0035418)2.50688077
70dendritic spine morphogenesis (GO:0060997)2.49519120
71low-density lipoprotein particle remodeling (GO:0034374)2.49355871
72peptidyl-glutamic acid modification (GO:0018200)2.48142090
73synapse assembly (GO:0007416)2.47489154
74auditory receptor cell stereocilium organization (GO:0060088)2.47338174
75regulation of glycogen (starch) synthase activity (GO:2000465)2.45614800
76primary amino compound metabolic process (GO:1901160)2.45486671
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.45445156
78calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44295754
79positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.42338311
80indolalkylamine metabolic process (GO:0006586)2.42266120
81negative regulation of cell cycle arrest (GO:0071157)2.41131960
82valine metabolic process (GO:0006573)2.39130467
83membrane depolarization during action potential (GO:0086010)2.37666272
84positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.36975591
85phasic smooth muscle contraction (GO:0014821)2.35278708
86embryonic body morphogenesis (GO:0010172)2.35160187
87establishment of mitochondrion localization (GO:0051654)2.34168468
88synaptic transmission, glutamatergic (GO:0035249)2.30012597
89phosphatidylcholine biosynthetic process (GO:0006656)2.29961552
90inositol phosphate catabolic process (GO:0071545)2.29715875
91neuron cell-cell adhesion (GO:0007158)2.29443537
92triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.29399014
93neuron recognition (GO:0008038)2.29049632
94cholesterol efflux (GO:0033344)2.28547260
95cornea development in camera-type eye (GO:0061303)2.27733634
96axonal fasciculation (GO:0007413)2.27486105
97lung epithelium development (GO:0060428)2.26621812
98sex determination (GO:0007530)2.25400434
99positive regulation of glycogen biosynthetic process (GO:0045725)2.24665740
100preassembly of GPI anchor in ER membrane (GO:0016254)2.22829110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09637843
2GBX2_23144817_ChIP-Seq_PC3_Human3.34977496
3* ZNF274_21170338_ChIP-Seq_K562_Hela3.31832235
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45658139
5DROSHA_22980978_ChIP-Seq_HELA_Human2.39093127
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20548100
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15915220
8REST_21632747_ChIP-Seq_MESCs_Mouse2.11475128
9VDR_22108803_ChIP-Seq_LS180_Human2.09257053
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02313940
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.00475021
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90414925
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75693174
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71575419
15REST_18959480_ChIP-ChIP_MESCs_Mouse1.71101169
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68841576
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.64390325
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61696917
19IGF1R_20145208_ChIP-Seq_DFB_Human1.61515878
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61183520
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58142172
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55674856
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54005055
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53485561
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53235273
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.51451448
27ERA_21632823_ChIP-Seq_H3396_Human1.49058119
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48943755
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48221368
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.42954560
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42873872
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40399340
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39845306
34* MYC_19829295_ChIP-Seq_ESCs_Human1.36632884
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35104614
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.32971740
37RNF2_27304074_Chip-Seq_NSC_Mouse1.29788776
38OCT4_20526341_ChIP-Seq_ESCs_Human1.29525858
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28864309
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27953065
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.27344156
42AR_21572438_ChIP-Seq_LNCaP_Human1.27274190
43RAC3_21632823_ChIP-Seq_H3396_Human1.26523991
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25535142
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.24743149
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24224048
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21412533
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21278301
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.19585397
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19308011
51BCAT_22108803_ChIP-Seq_LS180_Human1.19219543
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19199340
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17959255
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16910587
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15666551
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15666551
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.15386915
58TP53_22573176_ChIP-Seq_HFKS_Human1.11559380
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11496981
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11280891
61FOXH1_21741376_ChIP-Seq_ESCs_Human1.11186955
62CTCF_27219007_Chip-Seq_Bcells_Human1.09779925
63TCF4_23295773_ChIP-Seq_U87_Human1.09627410
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09302070
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09302070
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09105605
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08149428
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04745006
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03574647
70ER_23166858_ChIP-Seq_MCF-7_Human1.02812262
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99711044
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98591987
73P68_20966046_ChIP-Seq_HELA_Human0.98343138
74* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97950215
75* E2F1_20622854_ChIP-Seq_HELA_Human0.97910608
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96770950
77* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96667835
78EED_16625203_ChIP-ChIP_MESCs_Mouse0.96344668
79TAF2_19829295_ChIP-Seq_ESCs_Human0.96293928
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96117694
81* PHF8_20622854_ChIP-Seq_HELA_Human0.95782040
82HOXB7_26014856_ChIP-Seq_BT474_Human0.95556155
83HNF4A_19822575_ChIP-Seq_HepG2_Human0.93318170
84P53_21459846_ChIP-Seq_SAOS-2_Human0.92415003
85OCT4_19829295_ChIP-Seq_ESCs_Human0.91635864
86RARB_24833708_ChIP-Seq_LIVER_Mouse0.90762149
87NCOR_22424771_ChIP-Seq_293T_Human0.90434815
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90101247
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89175049
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88124776
91NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87572725
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86429350
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.85910880
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.84879131
95* FOXP1_21924763_ChIP-Seq_HESCs_Human0.84806010
96RING1B_27294783_Chip-Seq_ESCs_Mouse0.84776440
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.84753546
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84298470
99* AR_19668381_ChIP-Seq_PC3_Human0.83562553
100P300_19829295_ChIP-Seq_ESCs_Human0.83213968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.35516442
2MP0003195_calcinosis3.32938125
3MP0005499_abnormal_olfactory_system2.75994702
4MP0005394_taste/olfaction_phenotype2.75994702
5MP0008789_abnormal_olfactory_epithelium2.68425649
6MP0005360_urolithiasis2.65289115
7MP0002909_abnormal_adrenal_gland2.41844477
8MP0000566_synostosis2.33662258
9MP0005551_abnormal_eye_electrophysiolog2.20290350
10MP0003787_abnormal_imprinting2.16322580
11MP0005365_abnormal_bile_salt2.11830589
12MP0003646_muscle_fatigue2.11072882
13MP0001968_abnormal_touch/_nociception2.09244049
14MP0004859_abnormal_synaptic_plasticity2.02810372
15MP0008875_abnormal_xenobiotic_pharmacok1.95043262
16MP0004133_heterotaxia1.89346766
17MP0009745_abnormal_behavioral_response1.87542500
18MP0009046_muscle_twitch1.84852870
19MP0005423_abnormal_somatic_nervous1.82112049
20MP0006292_abnormal_olfactory_placode1.79825370
21MP0003121_genomic_imprinting1.76926285
22MP0005646_abnormal_pituitary_gland1.76142865
23MP0010329_abnormal_lipoprotein_level1.74619471
24MP0003880_abnormal_central_pattern1.67932346
25MP0003172_abnormal_lysosome_physiology1.66354109
26MP0002837_dystrophic_cardiac_calcinosis1.66184338
27MP0001486_abnormal_startle_reflex1.65955529
28MP0002064_seizures1.64103786
29MP0005379_endocrine/exocrine_gland_phen1.63288420
30MP0002557_abnormal_social/conspecific_i1.60274286
31MP0003635_abnormal_synaptic_transmissio1.55558554
32MP0004270_analgesia1.55339381
33MP0002572_abnormal_emotion/affect_behav1.54762305
34MP0002638_abnormal_pupillary_reflex1.53839645
35MP0002254_reproductive_system_inflammat1.50815945
36MP0001984_abnormal_olfaction1.49128192
37MP0001529_abnormal_vocalization1.46377063
38MP0002063_abnormal_learning/memory/cond1.44702440
39MP0002938_white_spotting1.43611991
40MP0008877_abnormal_DNA_methylation1.41497392
41MP0002272_abnormal_nervous_system1.41122349
42MP0004043_abnormal_pH_regulation1.39475436
43MP0000631_abnormal_neuroendocrine_gland1.38671502
44MP0001501_abnormal_sleep_pattern1.30984281
45MP0000778_abnormal_nervous_system1.28882389
46MP0009780_abnormal_chondrocyte_physiolo1.26940066
47MP0002876_abnormal_thyroid_physiology1.22026310
48MP0006276_abnormal_autonomic_nervous1.20474104
49MP0008872_abnormal_physiological_respon1.20220128
50MP0001970_abnormal_pain_threshold1.19938400
51MP0002733_abnormal_thermal_nociception1.19074537
52MP0000639_abnormal_adrenal_gland1.16858072
53MP0002184_abnormal_innervation1.16365454
54MP0001986_abnormal_taste_sensitivity1.08777243
55MP0004924_abnormal_behavior1.06302177
56MP0005386_behavior/neurological_phenoty1.06302177
57MP0003123_paternal_imprinting1.05914902
58MP0000427_abnormal_hair_cycle1.05450166
59MP0005253_abnormal_eye_physiology1.05303962
60MP0002089_abnormal_postnatal_growth/wei1.04025530
61MP0002734_abnormal_mechanical_nocicepti1.03861281
62MP0005645_abnormal_hypothalamus_physiol1.03283297
63MP0001270_distended_abdomen1.02039912
64MP0002067_abnormal_sensory_capabilities1.01383054
65MP0006072_abnormal_retinal_apoptosis1.00893380
66MP0002735_abnormal_chemical_nociception0.99596386
67MP0004885_abnormal_endolymph0.98669310
68MP0000955_abnormal_spinal_cord0.98561167
69MP0001502_abnormal_circadian_rhythm0.98482807
70MP0002736_abnormal_nociception_after0.97446327
71MP0000538_abnormal_urinary_bladder0.97059073
72MP0002229_neurodegeneration0.96790828
73MP0001324_abnormal_eye_pigmentation0.95715550
74MP0002249_abnormal_larynx_morphology0.95175482
75MP0010386_abnormal_urinary_bladder0.93216400
76MP0004142_abnormal_muscle_tone0.92482955
77MP0002234_abnormal_pharynx_morphology0.91527520
78MP0004742_abnormal_vestibular_system0.91027451
79MP0002882_abnormal_neuron_morphology0.90047033
80MP0003567_abnormal_fetal_cardiomyocyte0.88961633
81MP0002752_abnormal_somatic_nervous0.88689597
82MP0003136_yellow_coat_color0.88628558
83MP0005085_abnormal_gallbladder_physiolo0.87944879
84MP0005670_abnormal_white_adipose0.86981835
85MP0002693_abnormal_pancreas_physiology0.85327245
86MP0002102_abnormal_ear_morphology0.85130264
87MP0005195_abnormal_posterior_eye0.83696378
88MP0003938_abnormal_ear_development0.82456191
89MP0001348_abnormal_lacrimal_gland0.82292653
90MP0000026_abnormal_inner_ear0.81952548
91MP0002233_abnormal_nose_morphology0.78245889
92MP0003633_abnormal_nervous_system0.76749637
93MP0002751_abnormal_autonomic_nervous0.75758615
94MP0002822_catalepsy0.74392617
95MP0004130_abnormal_muscle_cell0.74186470
96MP0002152_abnormal_brain_morphology0.73220891
97MP0005083_abnormal_biliary_tract0.72148887
98MP0003252_abnormal_bile_duct0.71147848
99MP0005332_abnormal_amino_acid0.71129825
100MP0002118_abnormal_lipid_homeostasis0.70738951

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.68090133
2Nephronophthisis (HP:0000090)3.56083513
3Joint hemorrhage (HP:0005261)3.33167597
4Deep venous thrombosis (HP:0002625)3.18095892
5Epileptic encephalopathy (HP:0200134)3.16859229
6Focal seizures (HP:0007359)3.08126957
7Tubular atrophy (HP:0000092)3.07652968
8Pancreatic cysts (HP:0001737)3.05170311
9Lymphangioma (HP:0100764)3.03628656
10Abnormality of midbrain morphology (HP:0002418)2.95445306
11Molar tooth sign on MRI (HP:0002419)2.95445306
12Abnormality of the renal cortex (HP:0011035)2.91887900
13Abnormality of the renal medulla (HP:0100957)2.87697294
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.87133503
15Broad-based gait (HP:0002136)2.86774380
16Focal motor seizures (HP:0011153)2.82466235
17Rectal prolapse (HP:0002035)2.76228244
18Congenital stationary night blindness (HP:0007642)2.67407557
19Prolonged partial thromboplastin time (HP:0003645)2.65893100
20Type II lissencephaly (HP:0007260)2.64489172
21Attenuation of retinal blood vessels (HP:0007843)2.52765915
22Bony spicule pigmentary retinopathy (HP:0007737)2.50466232
23Pendular nystagmus (HP:0012043)2.48183920
24Abnormal rod and cone electroretinograms (HP:0008323)2.48039171
25Vitreoretinal degeneration (HP:0000655)2.44889644
26Hypochromic anemia (HP:0001931)2.40680939
27Medial flaring of the eyebrow (HP:0010747)2.33847245
28Genetic anticipation (HP:0003743)2.33838246
29Gait imbalance (HP:0002141)2.32707770
30Concave nail (HP:0001598)2.31747668
31Severe muscular hypotonia (HP:0006829)2.30157205
32Lissencephaly (HP:0001339)2.26634474
33Stomatitis (HP:0010280)2.26366104
34Hyperglycinuria (HP:0003108)2.23448855
35Dialeptic seizures (HP:0011146)2.21569197
36Cerebellar dysplasia (HP:0007033)2.15978195
37Abolished electroretinogram (ERG) (HP:0000550)2.14758049
38Ketosis (HP:0001946)2.14724638
39Amblyopia (HP:0000646)2.12479619
40True hermaphroditism (HP:0010459)2.10832057
41Epidermoid cyst (HP:0200040)2.10479066
42Clumsiness (HP:0002312)2.08113353
43Agitation (HP:0000713)2.04709993
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04133093
45Absent speech (HP:0001344)2.03250044
46Cystic liver disease (HP:0006706)2.03185179
47Febrile seizures (HP:0002373)2.02733962
48Status epilepticus (HP:0002133)2.01398205
49Absent epiphyses (HP:0010577)2.01149807
50Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01149807
51Congenital primary aphakia (HP:0007707)2.00580438
52Vaginal fistula (HP:0004320)2.00099433
53Broad alveolar ridges (HP:0000187)1.99878796
54Abnormality of serine family amino acid metabolism (HP:0010894)1.96194185
55Abnormality of glycine metabolism (HP:0010895)1.96194185
56Hepatoblastoma (HP:0002884)1.95911235
57Hyperglycinemia (HP:0002154)1.94325629
58Pachygyria (HP:0001302)1.93584616
59Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93459988
60Renovascular hypertension (HP:0100817)1.93287126
61Abnormality of the aortic arch (HP:0012303)1.92658613
62Abnormal pupillary function (HP:0007686)1.91684067
63Hypothermia (HP:0002045)1.91597721
64Polydipsia (HP:0001959)1.88715503
65Abnormal drinking behavior (HP:0030082)1.88715503
66Progressive cerebellar ataxia (HP:0002073)1.87290674
67Abnormality of the pubic bones (HP:0003172)1.85832693
68Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85462047
69Renal hypoplasia (HP:0000089)1.85029054
70Hemiparesis (HP:0001269)1.82888730
71Anencephaly (HP:0002323)1.81701596
72Retinal atrophy (HP:0001105)1.81529890
73Xanthomatosis (HP:0000991)1.81198935
74Ketoacidosis (HP:0001993)1.78345793
75Abnormality of the vitreous humor (HP:0004327)1.78095658
76Pancreatic fibrosis (HP:0100732)1.77190692
77Rib fusion (HP:0000902)1.76156310
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.75115276
79Nephrogenic diabetes insipidus (HP:0009806)1.74880722
80Genital tract atresia (HP:0001827)1.74617646
81Methylmalonic aciduria (HP:0012120)1.73907260
82Hyperlipoproteinemia (HP:0010980)1.73032002
83Increased neuronal autofluorescent lipopigment (HP:0002074)1.69095070
84Stage 5 chronic kidney disease (HP:0003774)1.67107975
85Hypoplastic ischia (HP:0003175)1.65650072
86Vaginal atresia (HP:0000148)1.65568097
87Increased intramyocellular lipid droplets (HP:0012240)1.65454354
88Hypophosphatemic rickets (HP:0004912)1.65088397
89Disproportionate short-trunk short stature (HP:0003521)1.65048750
90Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64981683
91Abnormality of polysaccharide metabolism (HP:0011012)1.64981683
92Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64981683
93Anophthalmia (HP:0000528)1.64970378
94Retinal dysplasia (HP:0007973)1.63436059
95Inability to walk (HP:0002540)1.61988763
96Asplenia (HP:0001746)1.61263150
97Abnormality of the femoral head (HP:0003368)1.60461428
98Oligodontia (HP:0000677)1.60082788
99Keratoconus (HP:0000563)1.59610543
100Increased corneal curvature (HP:0100692)1.59610543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.35202682
2TNK23.31404402
3WNK42.81979329
4WNK32.65658277
5MARK12.65076258
6MAP4K22.52613691
7FGFR22.37632182
8NUAK12.34590581
9NTRK32.29304061
10INSRR2.21076178
11CASK2.17569663
12ADRBK22.11696469
13SIK21.98377361
14LATS11.97206760
15DYRK21.91224418
16MAP2K61.81755547
17MAP2K21.75109311
18PHKG21.71662526
19PHKG11.71662526
20NTRK21.71113620
21MAPK131.70889910
22MAP3K41.65512451
23EPHA41.63040829
24MAP3K71.51859903
25FGFR41.46316513
26PRKD31.44049309
27DYRK1A1.43523036
28TLK11.43291869
29PIK3CA1.42917068
30SIK11.33985808
31CDC42BPA1.25719071
32STK38L1.20651203
33GRK11.11306986
34DYRK1B1.08616667
35PKN21.04474309
36DAPK21.01541274
37PKN10.99412569
38MAP2K10.99017081
39BRSK10.98158239
40SGK2230.97524601
41SGK4940.97524601
42PRKCG0.96103813
43PAK30.94152322
44PINK10.91658857
45PRKCZ0.91385592
46TYRO30.87317943
47PRKAA10.84122220
48STK160.84001561
49ERBB20.83533788
50BCKDK0.82001841
51TRIB30.81538704
52CAMK1D0.81535670
53NME10.81369582
54FGFR30.80464654
55CCNB10.75932746
56CAMK10.74344649
57BRD40.74263679
58MAP2K40.72669450
59NEK90.69479172
60ICK0.68881122
61CAMK40.67021083
62CAMKK10.63431830
63STK110.63267707
64PRKD20.61259412
65CSNK1D0.60139525
66MUSK0.59732123
67STK390.57337564
68MAPK150.53313471
69RET0.53307137
70PRKCI0.53128039
71LIMK10.51666589
72ITK0.50836388
73MARK20.50181329
74HIPK20.49969301
75ERBB30.49417084
76STK380.48139056
77ADRBK10.47074065
78CAMK2A0.47011318
79PRKAA20.45688650
80CDK50.45397370
81GRK50.45301228
82PRKCE0.44822630
83MAPK120.43631640
84FGFR10.43310495
85PRKACA0.42669882
86CSNK1G30.42228203
87ROCK10.41746661
88CSNK1A1L0.41597303
89WNK10.41356890
90TNIK0.41338553
91SGK10.41141305
92OXSR10.40263787
93FER0.39594050
94CAMK1G0.39009173
95CAMK2B0.38534325
96CSNK1G10.37408002
97MINK10.37255850
98PLK40.35028550
99PRKG10.34413681
100CHUK0.34203354

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.04213920
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39494954
3Vitamin B6 metabolism_Homo sapiens_hsa007502.29059838
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.29008251
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15177814
6Phototransduction_Homo sapiens_hsa047442.14481825
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.13004899
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01543049
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.99981141
10Nicotine addiction_Homo sapiens_hsa050331.99712469
11Propanoate metabolism_Homo sapiens_hsa006401.97423010
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95998320
13Butanoate metabolism_Homo sapiens_hsa006501.94574501
14Complement and coagulation cascades_Homo sapiens_hsa046101.93751355
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.86078472
16Steroid biosynthesis_Homo sapiens_hsa001001.81772173
17ABC transporters_Homo sapiens_hsa020101.79019711
18Lysine degradation_Homo sapiens_hsa003101.73539535
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69017128
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65574170
21Linoleic acid metabolism_Homo sapiens_hsa005911.58511486
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.58418461
23Taste transduction_Homo sapiens_hsa047421.56186927
24Fat digestion and absorption_Homo sapiens_hsa049751.52068400
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42817632
26Sphingolipid metabolism_Homo sapiens_hsa006001.37187606
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35298342
28Insulin secretion_Homo sapiens_hsa049111.28555460
29Asthma_Homo sapiens_hsa053101.27281741
30Glutamatergic synapse_Homo sapiens_hsa047241.23443193
31Circadian entrainment_Homo sapiens_hsa047131.22841330
32Ether lipid metabolism_Homo sapiens_hsa005651.19172862
33Nitrogen metabolism_Homo sapiens_hsa009101.19030285
34Morphine addiction_Homo sapiens_hsa050321.18758974
35Staphylococcus aureus infection_Homo sapiens_hsa051501.16610240
36beta-Alanine metabolism_Homo sapiens_hsa004101.14921134
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12591233
38Regulation of autophagy_Homo sapiens_hsa041401.11193830
39Type I diabetes mellitus_Homo sapiens_hsa049401.10883771
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09339385
41GABAergic synapse_Homo sapiens_hsa047271.07483930
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06132165
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02191340
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.99892582
45Tryptophan metabolism_Homo sapiens_hsa003800.97574121
46Peroxisome_Homo sapiens_hsa041460.95582734
47Ovarian steroidogenesis_Homo sapiens_hsa049130.93793894
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93496214
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92595696
50Calcium signaling pathway_Homo sapiens_hsa040200.91125960
51Cholinergic synapse_Homo sapiens_hsa047250.90714353
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89838663
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89389819
54Olfactory transduction_Homo sapiens_hsa047400.88137439
55Other glycan degradation_Homo sapiens_hsa005110.83835039
56Graft-versus-host disease_Homo sapiens_hsa053320.83565680
57Glycerolipid metabolism_Homo sapiens_hsa005610.81789440
58Fatty acid metabolism_Homo sapiens_hsa012120.81667967
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79621465
60Axon guidance_Homo sapiens_hsa043600.79097242
61Dopaminergic synapse_Homo sapiens_hsa047280.75505338
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.73803758
63Renin secretion_Homo sapiens_hsa049240.70924908
64Autoimmune thyroid disease_Homo sapiens_hsa053200.70044750
65Arginine and proline metabolism_Homo sapiens_hsa003300.69211253
66Allograft rejection_Homo sapiens_hsa053300.68343707
67Type II diabetes mellitus_Homo sapiens_hsa049300.67581106
68cAMP signaling pathway_Homo sapiens_hsa040240.65734919
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63659318
70mTOR signaling pathway_Homo sapiens_hsa041500.62447202
71Choline metabolism in cancer_Homo sapiens_hsa052310.61516986
72Glucagon signaling pathway_Homo sapiens_hsa049220.61450785
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61242105
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60920100
75Histidine metabolism_Homo sapiens_hsa003400.60307520
76Chemical carcinogenesis_Homo sapiens_hsa052040.59681040
77PPAR signaling pathway_Homo sapiens_hsa033200.57354669
78AMPK signaling pathway_Homo sapiens_hsa041520.56515739
79Inositol phosphate metabolism_Homo sapiens_hsa005620.56067543
80Sulfur relay system_Homo sapiens_hsa041220.55452387
81Circadian rhythm_Homo sapiens_hsa047100.55210986
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55129761
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54253440
84VEGF signaling pathway_Homo sapiens_hsa043700.53369292
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51632409
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50233874
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50144734
88Fatty acid degradation_Homo sapiens_hsa000710.49438742
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49364797
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49123351
91Cocaine addiction_Homo sapiens_hsa050300.48968022
92Salivary secretion_Homo sapiens_hsa049700.44927781
93Basal cell carcinoma_Homo sapiens_hsa052170.44548858
94Serotonergic synapse_Homo sapiens_hsa047260.44314043
95Caffeine metabolism_Homo sapiens_hsa002320.43612269
96Insulin resistance_Homo sapiens_hsa049310.43349775
97Arachidonic acid metabolism_Homo sapiens_hsa005900.42941779
98Bile secretion_Homo sapiens_hsa049760.42657795
99Vitamin digestion and absorption_Homo sapiens_hsa049770.41788597
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.39990472

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