ZNF518A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Numerous transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.70080801
2mitotic sister chromatid cohesion (GO:0007064)3.93479693
3synapsis (GO:0007129)3.80377241
4resolution of meiotic recombination intermediates (GO:0000712)3.67628661
5nuclear pore complex assembly (GO:0051292)3.60671425
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.58193378
7regulation of translation, ncRNA-mediated (GO:0045974)3.58193378
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.58193378
9nuclear pore organization (GO:0006999)3.49806456
10pre-miRNA processing (GO:0031054)3.45062614
11neural tube formation (GO:0001841)3.41650388
12male meiosis (GO:0007140)3.39869485
13regulation of meiosis I (GO:0060631)3.39391336
14intraciliary transport (GO:0042073)3.36135242
15otic vesicle formation (GO:0030916)3.35834726
16regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.35506038
17intra-S DNA damage checkpoint (GO:0031573)3.27189201
18mRNA cleavage (GO:0006379)3.24856632
19kidney morphogenesis (GO:0060993)3.17977623
20histone exchange (GO:0043486)3.16087948
21epithelial cilium movement (GO:0003351)3.14994078
22regulation of acyl-CoA biosynthetic process (GO:0050812)3.14090741
23histone H3-K36 demethylation (GO:0070544)3.11809789
24piRNA metabolic process (GO:0034587)3.07031454
25peptidyl-lysine trimethylation (GO:0018023)3.02314650
26presynaptic membrane assembly (GO:0097105)2.99538676
27regulation of protein glycosylation (GO:0060049)2.97172781
28regulation of mitotic spindle checkpoint (GO:1903504)2.96707285
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96707285
30establishment of protein localization to Golgi (GO:0072600)2.95292997
31acrosome assembly (GO:0001675)2.95198125
32replication fork processing (GO:0031297)2.91077847
33chromatin remodeling at centromere (GO:0031055)2.90431064
34genitalia morphogenesis (GO:0035112)2.88746680
35centriole replication (GO:0007099)2.88666393
36microtubule anchoring (GO:0034453)2.88400303
37monoubiquitinated protein deubiquitination (GO:0035520)2.88266260
38centriole assembly (GO:0098534)2.87652277
39gene silencing by RNA (GO:0031047)2.87179952
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83892571
41negative regulation of DNA-dependent DNA replication (GO:2000104)2.80763548
42regulation of centriole replication (GO:0046599)2.79588928
43sister chromatid cohesion (GO:0007062)2.79359825
44regulation of posttranscriptional gene silencing (GO:0060147)2.79264519
45regulation of gene silencing by miRNA (GO:0060964)2.79264519
46regulation of gene silencing by RNA (GO:0060966)2.79264519
47protein localization to cilium (GO:0061512)2.76431758
48paraxial mesoderm development (GO:0048339)2.75937250
49somite rostral/caudal axis specification (GO:0032525)2.75679829
50histone H2A acetylation (GO:0043968)2.75444321
51regulation of phosphoprotein phosphatase activity (GO:0043666)2.74926618
52regulation of centrosome duplication (GO:0010824)2.73335111
53meiotic chromosome segregation (GO:0045132)2.72399455
54protein targeting to Golgi (GO:0000042)2.71405709
55regulation of histone H3-K9 methylation (GO:0051570)2.70753783
56regulation of coenzyme metabolic process (GO:0051196)2.68084748
57regulation of cofactor metabolic process (GO:0051193)2.68084748
58CENP-A containing nucleosome assembly (GO:0034080)2.66479757
59regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.65301789
60double-strand break repair via nonhomologous end joining (GO:0006303)2.63876562
61non-recombinational repair (GO:0000726)2.63876562
62N-terminal protein amino acid acetylation (GO:0006474)2.62970001
63negative regulation of DNA recombination (GO:0045910)2.62428717
64cilium movement (GO:0003341)2.61063704
65DNA integration (GO:0015074)2.59238013
66regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59201368
67cilium organization (GO:0044782)2.58959036
68positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.57935082
69positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.57935082
70positive regulation of mitotic sister chromatid separation (GO:1901970)2.57935082
71L-fucose catabolic process (GO:0042355)2.57898724
72fucose catabolic process (GO:0019317)2.57898724
73L-fucose metabolic process (GO:0042354)2.57898724
74V(D)J recombination (GO:0033151)2.57525370
75regulation of pigment cell differentiation (GO:0050932)2.57408802
76cilium assembly (GO:0042384)2.57176244
77cytoplasmic mRNA processing body assembly (GO:0033962)2.54088814
78DNA methylation involved in gamete generation (GO:0043046)2.53343328
79positive regulation of histone H3-K4 methylation (GO:0051571)2.53072289
80presynaptic membrane organization (GO:0097090)2.51353028
81regulation of sulfur metabolic process (GO:0042762)2.50337912
82histone mRNA catabolic process (GO:0071044)2.50065718
83cilium or flagellum-dependent cell motility (GO:0001539)2.49920265
84embryonic foregut morphogenesis (GO:0048617)2.47566299
85phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47299968
86dorsal/ventral axis specification (GO:0009950)2.46593194
87spindle checkpoint (GO:0031577)2.45446883
88positive regulation of developmental pigmentation (GO:0048087)2.45352892
89pancreas development (GO:0031016)2.44688651
90retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44195638
91male sex determination (GO:0030238)2.43249152
92DNA ligation (GO:0006266)2.43070521
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.42739371
94double-strand break repair via homologous recombination (GO:0000724)2.41929888
95ventricular system development (GO:0021591)2.41887919
96pore complex assembly (GO:0046931)2.41760986
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41621239
98limb bud formation (GO:0060174)2.40656149
99cilium morphogenesis (GO:0060271)2.39927826
100kinetochore organization (GO:0051383)2.39022669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.01239869
2IGF1R_20145208_ChIP-Seq_DFB_Human3.51824743
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.47459133
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.28146564
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.98594129
6GBX2_23144817_ChIP-Seq_PC3_Human2.77512746
7FUS_26573619_Chip-Seq_HEK293_Human2.74991437
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.71233677
9ZNF274_21170338_ChIP-Seq_K562_Hela2.49177476
10EWS_26573619_Chip-Seq_HEK293_Human2.40615383
11VDR_22108803_ChIP-Seq_LS180_Human2.39868610
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33763506
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25417496
14TAF15_26573619_Chip-Seq_HEK293_Human2.25132176
15P300_19829295_ChIP-Seq_ESCs_Human2.21837177
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20205494
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02952403
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.94535149
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92984187
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91441540
21E2F7_22180533_ChIP-Seq_HELA_Human1.89116595
22ER_23166858_ChIP-Seq_MCF-7_Human1.85571567
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84558030
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81494231
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80640586
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80548546
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78572255
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77330011
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76338967
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.67278985
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65776296
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65776296
33BCAT_22108803_ChIP-Seq_LS180_Human1.59972328
34STAT3_23295773_ChIP-Seq_U87_Human1.59774687
35CBP_20019798_ChIP-Seq_JUKART_Human1.59720688
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59720688
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58120444
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.57147286
39* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57057834
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.54487553
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52707708
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51361218
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51033089
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46897311
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46607192
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45111946
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43792315
48TCF4_23295773_ChIP-Seq_U87_Human1.43605229
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43236843
50IRF1_19129219_ChIP-ChIP_H3396_Human1.39119793
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36811526
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33835040
53ELK1_19687146_ChIP-ChIP_HELA_Human1.32796916
54RUNX2_22187159_ChIP-Seq_PCA_Human1.30806373
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.30256026
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28438238
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.26719804
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26400202
59AR_25329375_ChIP-Seq_VCAP_Human1.25021804
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23932328
61TCF4_22108803_ChIP-Seq_LS180_Human1.22987456
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22825628
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20100615
64CDX2_22108803_ChIP-Seq_LS180_Human1.17454421
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15002555
66AR_21572438_ChIP-Seq_LNCaP_Human1.14824101
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14333647
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14015864
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13438795
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10429356
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10238952
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08976690
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.08725452
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07546870
75AR_21909140_ChIP-Seq_LNCAP_Human1.04786789
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04606591
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04409361
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.03683013
79SOX2_19829295_ChIP-Seq_ESCs_Human1.03024684
80NANOG_19829295_ChIP-Seq_ESCs_Human1.03024684
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.02736314
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.02606227
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.02081270
84P53_22387025_ChIP-Seq_ESCs_Mouse1.01105024
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.00030946
86MYC_18940864_ChIP-ChIP_HL60_Human0.99383068
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.99041150
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98321386
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97705349
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97291459
91RNF2_27304074_Chip-Seq_NSC_Mouse0.97287839
92P300_18555785_Chip-Seq_ESCs_Mouse0.96995127
93SMAD4_21741376_ChIP-Seq_EPCs_Human0.96942535
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96080982
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.95998393
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95416323
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.93618386
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.93478620
99AHR_22903824_ChIP-Seq_MCF-7_Human0.93306393
100TBL1_22424771_ChIP-Seq_293T_Human0.93084766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.31346658
2MP0008877_abnormal_DNA_methylation3.76818461
3MP0003890_abnormal_embryonic-extraembry3.26790271
4MP0003787_abnormal_imprinting2.59524132
5MP0003122_maternal_imprinting2.55998473
6MP0003121_genomic_imprinting2.39277749
7MP0006072_abnormal_retinal_apoptosis2.39119827
8MP0000569_abnormal_digit_pigmentation2.26849872
9MP0010094_abnormal_chromosome_stability2.19057719
10MP0009697_abnormal_copulation2.16513443
11MP0001188_hyperpigmentation2.08128207
12MP0001984_abnormal_olfaction2.00261018
13MP0002102_abnormal_ear_morphology1.97415748
14MP0005248_abnormal_Harderian_gland1.85780091
15MP0008058_abnormal_DNA_repair1.81803788
16MP0006292_abnormal_olfactory_placode1.79632668
17MP0002233_abnormal_nose_morphology1.78819256
18MP0002009_preneoplasia1.77632594
19MP0002160_abnormal_reproductive_system1.72598624
20MP0003937_abnormal_limbs/digits/tail_de1.71991115
21MP0001529_abnormal_vocalization1.69111927
22MP0000631_abnormal_neuroendocrine_gland1.64698193
23MP0003567_abnormal_fetal_cardiomyocyte1.59212897
24MP0000566_synostosis1.58174385
25MP0005646_abnormal_pituitary_gland1.57709547
26MP0001929_abnormal_gametogenesis1.55356363
27MP0003315_abnormal_perineum_morphology1.52099893
28MP0001293_anophthalmia1.50979419
29MP0005394_taste/olfaction_phenotype1.49598266
30MP0005499_abnormal_olfactory_system1.49598266
31MP0005645_abnormal_hypothalamus_physiol1.46526185
32MP0005253_abnormal_eye_physiology1.43505688
33MP0000383_abnormal_hair_follicle1.41399192
34MP0010678_abnormal_skin_adnexa1.38634774
35MP0005187_abnormal_penis_morphology1.38036873
36MP0003698_abnormal_male_reproductive1.35421150
37MP0003195_calcinosis1.33954413
38MP0002210_abnormal_sex_determination1.28760856
39MP0003119_abnormal_digestive_system1.24539216
40MP0001145_abnormal_male_reproductive1.23810731
41MP0002938_white_spotting1.22016346
42MP0000653_abnormal_sex_gland1.20599447
43MP0008789_abnormal_olfactory_epithelium1.20524549
44MP0000427_abnormal_hair_cycle1.19432939
45MP0001286_abnormal_eye_development1.16660151
46MP0003136_yellow_coat_color1.15088282
47MP0002084_abnormal_developmental_patter1.11101845
48MP0005391_vision/eye_phenotype1.09711458
49MP0005075_abnormal_melanosome_morpholog1.09555614
50MP0005551_abnormal_eye_electrophysiolog1.09129834
51MP0003943_abnormal_hepatobiliary_system1.08775511
52MP0003077_abnormal_cell_cycle1.08686134
53MP0001485_abnormal_pinna_reflex1.07362904
54MP0004133_heterotaxia1.07185738
55MP0008004_abnormal_stomach_pH1.06632925
56MP0003693_abnormal_embryo_hatching1.06453485
57MP0005174_abnormal_tail_pigmentation1.04703606
58MP0004197_abnormal_fetal_growth/weight/1.03909123
59MP0002837_dystrophic_cardiac_calcinosis1.03826329
60MP0000516_abnormal_urinary_system1.03539085
61MP0005367_renal/urinary_system_phenotyp1.03539085
62MP0002751_abnormal_autonomic_nervous1.01961339
63MP0009703_decreased_birth_body1.01464687
64MP0005410_abnormal_fertilization0.99328976
65MP0003718_maternal_effect0.99247243
66MP0002822_catalepsy0.99027798
67MP0000647_abnormal_sebaceous_gland0.97917677
68MP0000778_abnormal_nervous_system0.97338526
69MP0005220_abnormal_exocrine_pancreas0.96406267
70MP0003935_abnormal_craniofacial_develop0.95907240
71MP0002638_abnormal_pupillary_reflex0.95646049
72MP0003385_abnormal_body_wall0.95499344
73MP0008995_early_reproductive_senescence0.94408189
74MP0004215_abnormal_myocardial_fiber0.94339769
75MP0001486_abnormal_startle_reflex0.93459536
76MP0004957_abnormal_blastocyst_morpholog0.93375721
77MP0003938_abnormal_ear_development0.88506386
78MP0002697_abnormal_eye_size0.88387675
79MP0005389_reproductive_system_phenotype0.87851581
80MP0008007_abnormal_cellular_replicative0.87791248
81MP0010234_abnormal_vibrissa_follicle0.87291855
82MP0004264_abnormal_extraembryonic_tissu0.84996248
83MP0002127_abnormal_cardiovascular_syste0.84560967
84MP0010386_abnormal_urinary_bladder0.83408167
85MP0001697_abnormal_embryo_size0.82841066
86MP0005647_abnormal_sex_gland0.82713668
87MP0001177_atelectasis0.82508988
88MP0000428_abnormal_craniofacial_morphol0.82437417
89MP0005380_embryogenesis_phenotype0.79383093
90MP0001672_abnormal_embryogenesis/_devel0.79383093
91MP0002088_abnormal_embryonic_growth/wei0.79193815
92MP0002184_abnormal_innervation0.78094220
93MP0001324_abnormal_eye_pigmentation0.78043452
94MP0003123_paternal_imprinting0.77554337
95MP0002092_abnormal_eye_morphology0.77279754
96MP0004134_abnormal_chest_morphology0.77214678
97MP0001661_extended_life_span0.76270897
98MP0003984_embryonic_growth_retardation0.76222973
99MP0001666_abnormal_nutrient_absorption0.75183839
100MP0002928_abnormal_bile_duct0.74596284

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.30127484
2Hepatoblastoma (HP:0002884)3.25175080
3Abnormality of the labia minora (HP:0012880)3.24537982
4Papillary thyroid carcinoma (HP:0002895)3.16810392
5Abnormality of chromosome stability (HP:0003220)2.74913201
6Colon cancer (HP:0003003)2.73103256
7Chronic hepatic failure (HP:0100626)2.70776453
8Facial hemangioma (HP:0000329)2.69939130
9Intestinal atresia (HP:0011100)2.66930716
10Pancreatic cysts (HP:0001737)2.60030762
11Chromsome breakage (HP:0040012)2.59860619
12True hermaphroditism (HP:0010459)2.59290934
13Type II lissencephaly (HP:0007260)2.47266707
14Medial flaring of the eyebrow (HP:0010747)2.42376839
15Sex reversal (HP:0012245)2.42052926
16Abnormal sex determination (HP:0012244)2.42052926
17Hypothermia (HP:0002045)2.38426650
18Medulloblastoma (HP:0002885)2.34005059
19Thyroiditis (HP:0100646)2.32680465
20Pancreatic fibrosis (HP:0100732)2.31010858
21Thyroid carcinoma (HP:0002890)2.30618993
22Molar tooth sign on MRI (HP:0002419)2.29389615
23Abnormality of midbrain morphology (HP:0002418)2.29389615
24Nephroblastoma (Wilms tumor) (HP:0002667)2.28268576
25Tubulointerstitial nephritis (HP:0001970)2.27183733
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.25435711
27Embryonal renal neoplasm (HP:0011794)2.25231459
28Genital tract atresia (HP:0001827)2.24008132
29Poor coordination (HP:0002370)2.22416798
30Aqueductal stenosis (HP:0002410)2.20891498
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19903645
32Vaginal atresia (HP:0000148)2.18388671
33High anterior hairline (HP:0009890)2.18371340
34Neoplasm of the oral cavity (HP:0100649)2.17070514
35Abnormality of the ileum (HP:0001549)2.16817954
36Male pseudohermaphroditism (HP:0000037)2.16047889
37Nephronophthisis (HP:0000090)2.15316451
38Rhabdomyosarcoma (HP:0002859)2.14065185
39Median cleft lip (HP:0000161)2.13549959
40Meckel diverticulum (HP:0002245)2.13222701
41Congenital primary aphakia (HP:0007707)2.12527795
42Abnormal lung lobation (HP:0002101)2.12213512
43Hypoglycemic seizures (HP:0002173)2.07976197
44Pancreatic islet-cell hyperplasia (HP:0004510)2.07738141
45Sloping forehead (HP:0000340)2.07628057
46Abnormal biliary tract morphology (HP:0012440)2.07085970
47Abnormal pancreas size (HP:0012094)2.04647444
48Abnormal hair whorl (HP:0010721)2.03920532
49Neoplasm of the adrenal cortex (HP:0100641)2.03904701
50Enlarged kidneys (HP:0000105)2.03873540
51Capillary hemangiomas (HP:0005306)2.02637942
52Gait imbalance (HP:0002141)2.02199895
53Abnormality of the renal medulla (HP:0100957)1.99894368
54Protruding tongue (HP:0010808)1.97243870
55Hyperglycinemia (HP:0002154)1.96093582
56Retinal dysplasia (HP:0007973)1.96020042
57Abnormality of the renal cortex (HP:0011035)1.95588107
58Biliary tract neoplasm (HP:0100574)1.94503323
59Gaze-evoked nystagmus (HP:0000640)1.93654832
60Nephrogenic diabetes insipidus (HP:0009806)1.92335897
61Gonadal dysgenesis (HP:0000133)1.90601538
62Ectopic kidney (HP:0000086)1.89184345
63Hyperinsulinemic hypoglycemia (HP:0000825)1.87035980
64Bifid tongue (HP:0010297)1.86134522
65Gastrointestinal atresia (HP:0002589)1.85169257
66Postaxial hand polydactyly (HP:0001162)1.83830301
67Growth hormone deficiency (HP:0000824)1.83809938
68Cupped ear (HP:0000378)1.83626347
69Renal cortical cysts (HP:0000803)1.83493639
70Renal hypoplasia (HP:0000089)1.83330176
71Cerebellar dysplasia (HP:0007033)1.82596827
72Cystic liver disease (HP:0006706)1.82320180
73Glioma (HP:0009733)1.80768497
74Calf muscle hypertrophy (HP:0008981)1.78743850
75Astrocytoma (HP:0009592)1.78714717
76Abnormality of the astrocytes (HP:0100707)1.78714717
77Absent radius (HP:0003974)1.77547736
78Acute myeloid leukemia (HP:0004808)1.76275637
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.75767448
80Vitreoretinal degeneration (HP:0000655)1.74759946
81Acute lymphatic leukemia (HP:0006721)1.74741430
82Postaxial foot polydactyly (HP:0001830)1.74014220
83Dandy-Walker malformation (HP:0001305)1.73819244
84Optic nerve hypoplasia (HP:0000609)1.73219216
85Neoplasm of striated muscle (HP:0009728)1.72508198
86Oligodactyly (hands) (HP:0001180)1.72160733
87Clubbing of toes (HP:0100760)1.71428189
88Decreased lacrimation (HP:0000633)1.71285591
89Degeneration of the lateral corticospinal tracts (HP:0002314)1.70669173
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70669173
91Abnormal biliary tract physiology (HP:0012439)1.70583880
92Bile duct proliferation (HP:0001408)1.70583880
93Abnormality of the duodenum (HP:0002246)1.69880293
94Duodenal stenosis (HP:0100867)1.69866646
95Small intestinal stenosis (HP:0012848)1.69866646
96Scrotal hypoplasia (HP:0000046)1.69464410
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.68789063
98Febrile seizures (HP:0002373)1.65124941
99Curly hair (HP:0002212)1.65114555
100Truncal obesity (HP:0001956)1.64935333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.99758310
2PINK13.84207845
3ACVR1B2.64977469
4WNK32.62357515
5BMPR1B2.59231405
6TNIK2.48089193
7FGFR22.43714942
8STK38L2.37328952
9EIF2AK32.04790543
10MKNK22.04594864
11LATS12.04504636
12ZAK1.99143168
13MAP4K21.96411466
14CASK1.80792656
15MAP3K41.79714199
16PNCK1.78556832
17MKNK11.73294886
18MARK31.58967881
19STK391.58269077
20NEK21.55913990
21NLK1.54083289
22BRD41.53059919
23PLK41.51517725
24NUAK11.50985880
25BCR1.43458873
26CSNK1G11.40251574
27WEE11.33953579
28MST41.33847988
29CDK191.31385196
30CSNK1A1L1.29504994
31STK31.28083922
32MAP2K71.27743751
33CDC71.26825381
34OBSCN1.24369083
35TRIM281.22250889
36CSNK1G21.20824339
37BRSK21.19684984
38CSNK1G31.15412163
39CDK31.12368931
40ERBB31.06485230
41FGFR31.05761480
42AKT31.04935714
43FGFR11.03488057
44TGFBR11.02819007
45SRPK11.02791482
46TTK1.02613351
47MAP3K101.02111510
48PLK31.01370071
49TAF10.99825914
50OXSR10.97213351
51PKN20.97109252
52ATM0.96617216
53PASK0.95096022
54STK240.92272501
55DYRK30.91941012
56MAPK130.91459172
57SGK20.80124294
58TSSK60.79739065
59GRK10.79718777
60SGK2230.73368800
61SGK4940.73368800
62NTRK30.73102861
63ATR0.73026507
64MAP3K20.72521123
65FLT30.71739900
66PLK10.71701955
67RPS6KB10.69081580
68VRK10.66581700
69WNK10.65426579
70PAK30.64140747
71MELK0.62103974
72CAMK1G0.61922643
73KSR10.59184570
74DYRK20.58499037
75NTRK20.56873356
76PBK0.55298708
77PIK3CA0.52980140
78RPS6KA40.52347459
79WNK40.50817243
80YES10.49276053
81PRKCQ0.47734285
82RPS6KA50.47478689
83CSNK1E0.46271632
84CSNK1D0.45348403
85TEC0.45117893
86EGFR0.43472719
87CHEK10.42494859
88TLK10.41858127
89PRKCE0.37259236
90AURKB0.36592288
91EPHA40.36351615
92PLK20.35924920
93FGR0.33761437
94ADRBK20.33518056
95NEK10.33516144
96CHEK20.33218283
97SGK10.33156387
98CSNK1A10.32409663
99CDK10.32331114
100PRKG10.32310674

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.76143035
2Propanoate metabolism_Homo sapiens_hsa006402.75048365
3Fanconi anemia pathway_Homo sapiens_hsa034602.66180840
4Basal transcription factors_Homo sapiens_hsa030222.43044141
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.42384473
6Butanoate metabolism_Homo sapiens_hsa006502.32181230
7RNA degradation_Homo sapiens_hsa030182.25140251
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19566618
9Protein export_Homo sapiens_hsa030602.07165219
10Olfactory transduction_Homo sapiens_hsa047401.97166545
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91022325
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90948012
13Homologous recombination_Homo sapiens_hsa034401.80761246
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75746296
15mRNA surveillance pathway_Homo sapiens_hsa030151.75520150
16Hedgehog signaling pathway_Homo sapiens_hsa043401.73907188
17RNA transport_Homo sapiens_hsa030131.65263308
18Dorso-ventral axis formation_Homo sapiens_hsa043201.62873523
19Mismatch repair_Homo sapiens_hsa034301.58546963
20TGF-beta signaling pathway_Homo sapiens_hsa043501.50685056
21Oocyte meiosis_Homo sapiens_hsa041141.48027286
22Nitrogen metabolism_Homo sapiens_hsa009101.46397876
23Circadian rhythm_Homo sapiens_hsa047101.44753116
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42965135
25Phototransduction_Homo sapiens_hsa047441.40257687
26Steroid biosynthesis_Homo sapiens_hsa001001.37132210
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34288791
28Cell cycle_Homo sapiens_hsa041101.31691553
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30470048
30Alcoholism_Homo sapiens_hsa050341.26692635
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25971647
32Selenocompound metabolism_Homo sapiens_hsa004501.22813458
33Taste transduction_Homo sapiens_hsa047421.21022727
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17421359
35Lysine degradation_Homo sapiens_hsa003101.16351269
36Regulation of autophagy_Homo sapiens_hsa041401.14981662
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13559400
38Nucleotide excision repair_Homo sapiens_hsa034201.10535927
39Systemic lupus erythematosus_Homo sapiens_hsa053221.09761587
40Wnt signaling pathway_Homo sapiens_hsa043101.08605827
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.08009337
42Gap junction_Homo sapiens_hsa045401.01192034
43DNA replication_Homo sapiens_hsa030300.99754289
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98577943
45ABC transporters_Homo sapiens_hsa020100.92403801
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91882075
47Basal cell carcinoma_Homo sapiens_hsa052170.91134487
48Retinol metabolism_Homo sapiens_hsa008300.89581997
49Nicotine addiction_Homo sapiens_hsa050330.87718237
50Chemical carcinogenesis_Homo sapiens_hsa052040.84871424
51Vitamin digestion and absorption_Homo sapiens_hsa049770.83536346
52Fatty acid degradation_Homo sapiens_hsa000710.81255202
53Peroxisome_Homo sapiens_hsa041460.74080538
54beta-Alanine metabolism_Homo sapiens_hsa004100.72712957
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.72185983
56Tryptophan metabolism_Homo sapiens_hsa003800.71931080
57Hippo signaling pathway_Homo sapiens_hsa043900.71919672
58Vitamin B6 metabolism_Homo sapiens_hsa007500.71839344
59Fatty acid metabolism_Homo sapiens_hsa012120.70341561
60Renin secretion_Homo sapiens_hsa049240.70065326
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69560536
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67467208
63Glucagon signaling pathway_Homo sapiens_hsa049220.65585670
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65064126
65Amphetamine addiction_Homo sapiens_hsa050310.63695822
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63348082
67Circadian entrainment_Homo sapiens_hsa047130.63327250
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62641450
69p53 signaling pathway_Homo sapiens_hsa041150.61847195
70Purine metabolism_Homo sapiens_hsa002300.60337093
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59760108
72Inositol phosphate metabolism_Homo sapiens_hsa005620.59381756
73One carbon pool by folate_Homo sapiens_hsa006700.59356511
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58598892
75Dopaminergic synapse_Homo sapiens_hsa047280.58361161
76Spliceosome_Homo sapiens_hsa030400.57370345
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57114189
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54905716
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54287392
80Endometrial cancer_Homo sapiens_hsa052130.52629909
81Ether lipid metabolism_Homo sapiens_hsa005650.52366852
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52345669
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52129291
84FoxO signaling pathway_Homo sapiens_hsa040680.51917761
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50666222
86RNA polymerase_Homo sapiens_hsa030200.49411728
87Adherens junction_Homo sapiens_hsa045200.49217640
88Pyruvate metabolism_Homo sapiens_hsa006200.49172996
89Insulin secretion_Homo sapiens_hsa049110.48916314
90Prostate cancer_Homo sapiens_hsa052150.48639267
91Caffeine metabolism_Homo sapiens_hsa002320.46564329
92Glutamatergic synapse_Homo sapiens_hsa047240.43883928
93Histidine metabolism_Homo sapiens_hsa003400.43363332
94Tight junction_Homo sapiens_hsa045300.40683951
95Linoleic acid metabolism_Homo sapiens_hsa005910.40494340
96Salivary secretion_Homo sapiens_hsa049700.40184645
97Base excision repair_Homo sapiens_hsa034100.39671480
98Glycerolipid metabolism_Homo sapiens_hsa005610.39574689
99Colorectal cancer_Homo sapiens_hsa052100.38215795
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37672876

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »