ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.13984657
2	limb bud formation (GO:0060174)	4.09669579
3	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.96582072
4	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.96582072
5	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.96582072
6	neural tube formation (GO:0001841)	3.83172119
7	mitotic sister chromatid cohesion (GO:0007064)	3.61061813
8	embryonic foregut morphogenesis (GO:0048617)	3.55161852
9	presynaptic membrane assembly (GO:0097105)	3.53306211
10	neuron fate determination (GO:0048664)	3.50395703
11	regulation of DNA endoreduplication (GO:0032875)	3.48716522
12	olfactory bulb development (GO:0021772)	3.38778387
13	replication fork processing (GO:0031297)	3.30915689
14	somite development (GO:0061053)	3.30447769
15	regulation of meiosis I (GO:0060631)	3.29578513
16	prenylation (GO:0097354)	3.25880660
17	protein prenylation (GO:0018342)	3.25880660
18	atrial cardiac muscle cell action potential (GO:0086014)	3.21945416
19	establishment of protein localization to Golgi (GO:0072600)	3.15052652
20	microtubule anchoring (GO:0034453)	3.13040229
21	regulation of glucokinase activity (GO:0033131)	3.10615752
22	regulation of hexokinase activity (GO:1903299)	3.10615752
23	synapsis (GO:0007129)	3.10205793
24	keratinocyte development (GO:0003334)	3.09248853
25	gastrulation with mouth forming second (GO:0001702)	3.06930801
26	protein targeting to Golgi (GO:0000042)	3.05491554
27	kinetochore organization (GO:0051383)	3.05255847
28	artery development (GO:0060840)	3.04724267
29	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.03558119
30	genitalia morphogenesis (GO:0035112)	3.01629315
31	pancreas development (GO:0031016)	3.01481467
32	resolution of meiotic recombination intermediates (GO:0000712)	3.00627084
33	response to pheromone (GO:0019236)	2.95866849
34	protein K11-linked deubiquitination (GO:0035871)	2.94110522
35	cerebral cortex radially oriented cell migration (GO:0021799)	2.88174836
36	acrosome assembly (GO:0001675)	2.87865439
37	regulation of Rac protein signal transduction (GO:0035020)	2.87612377
38	histone H3-K4 trimethylation (GO:0080182)	2.86947195
39	kinetochore assembly (GO:0051382)	2.82032962
40	peptidyl-lysine trimethylation (GO:0018023)	2.81459685
41	presynaptic membrane organization (GO:0097090)	2.80971079
42	regulation of sister chromatid cohesion (GO:0007063)	2.80618890
43	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.75501369
44	intraciliary transport (GO:0042073)	2.74707518
45	postreplication repair (GO:0006301)	2.74585148
46	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.73249646
47	negative regulation of neurotransmitter secretion (GO:0046929)	2.72368540
48	cellular ketone body metabolic process (GO:0046950)	2.68963639
49	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.68897668
50	platelet dense granule organization (GO:0060155)	2.68474029
51	negative regulation of neurotransmitter transport (GO:0051589)	2.67721703
52	non-recombinational repair (GO:0000726)	2.66627156
53	double-strand break repair via nonhomologous end joining (GO:0006303)	2.66627156
54	otic vesicle formation (GO:0030916)	2.66468500
55	negative regulation of DNA recombination (GO:0045910)	2.65368252
56	embryonic digestive tract morphogenesis (GO:0048557)	2.64783752
57	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.62430936
58	centriole replication (GO:0007099)	2.62035836
59	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.62015792
60	dorsal/ventral axis specification (GO:0009950)	2.61799438
61	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.60419264
62	translesion synthesis (GO:0019985)	2.59824683
63	central nervous system projection neuron axonogenesis (GO:0021952)	2.59021665
64	double-strand break repair via homologous recombination (GO:0000724)	2.57504577
65	protein localization to microtubule cytoskeleton (GO:0072698)	2.57088090
66	recombinational repair (GO:0000725)	2.56612515
67	central nervous system neuron axonogenesis (GO:0021955)	2.55623137
68	pyrimidine nucleobase catabolic process (GO:0006208)	2.55579281
69	microtubule depolymerization (GO:0007019)	2.54040728
70	regulation of keratinocyte proliferation (GO:0010837)	2.53892674
71	positive regulation of protein autophosphorylation (GO:0031954)	2.53816273
72	retinal ganglion cell axon guidance (GO:0031290)	2.52959151
73	kidney morphogenesis (GO:0060993)	2.52495794
74	ketone body metabolic process (GO:1902224)	2.52482757
75	histone mRNA catabolic process (GO:0071044)	2.52314213
76	myelin assembly (GO:0032288)	2.51980558
77	fibroblast migration (GO:0010761)	2.51465180
78	monoubiquitinated protein deubiquitination (GO:0035520)	2.51300530
79	metaphase plate congression (GO:0051310)	2.49052619
80	sister chromatid cohesion (GO:0007062)	2.48031926
81	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.44788715
82	regulation of sulfur metabolic process (GO:0042762)	2.43413692
83	spermatid nucleus differentiation (GO:0007289)	2.43377529
84	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.42562447
85	regulation of translation, ncRNA-mediated (GO:0045974)	2.42562447
86	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.42562447
87	pre-miRNA processing (GO:0031054)	2.40752100
88	cilium morphogenesis (GO:0060271)	2.40706222
89	forebrain neuron differentiation (GO:0021879)	2.40201899
90	protein localization to Golgi apparatus (GO:0034067)	2.39603758
91	attachment of spindle microtubules to kinetochore (GO:0008608)	2.39541935
92	lactate metabolic process (GO:0006089)	2.38594802
93	histone H2A acetylation (GO:0043968)	2.38461604
94	female gonad development (GO:0008585)	2.37250728
95	DNA integration (GO:0015074)	2.35888697
96	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.35212263
97	anterior/posterior axis specification (GO:0009948)	2.33918366
98	protein K6-linked ubiquitination (GO:0085020)	2.33747898
99	interleukin-6-mediated signaling pathway (GO:0070102)	2.33616358
100	dentate gyrus development (GO:0021542)	2.33612987

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.68693601
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.27187830
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.08714191
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77982551
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.72787448
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.59412308
7	FUS_26573619_Chip-Seq_HEK293_Human	2.49815607
8	EWS_26573619_Chip-Seq_HEK293_Human	2.47789132
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.46837422
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.42578338
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34544159
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31091534
13	VDR_22108803_ChIP-Seq_LS180_Human	2.24676898
14	P300_19829295_ChIP-Seq_ESCs_Human	2.23316166
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20335747
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.13168490
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.03883448
18	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.94018138
19	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.92754738
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.85660157
21	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.84884355
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.82367605
23	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.81685663
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.80915917
25	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.80056929
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.77651558
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76775735
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72466857
29	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.71491520
30	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.68597302
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66182571
32	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63864619
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62189828
34	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.61698795
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58580468
36	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.56267142
37	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.54208051
38	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53487971
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.52108567
40	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.51648945
41	STAT3_23295773_ChIP-Seq_U87_Human	1.51373503
42	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.51015294
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.50926769
44	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.50621781
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.49508906
46	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44622747
47	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.43767301
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43685640
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41782656
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41743533
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.39522665
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39522665
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.37166630
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.37033872
55	AR_25329375_ChIP-Seq_VCAP_Human	1.35883006
56	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.35125243
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34886124
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.33380013
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.33365012
60	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.32337343
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31975003
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31730173
63	* TCF4_23295773_ChIP-Seq_U87_Human	1.28888853
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27838727
65	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.23884800
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23492600
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23339985
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.23305708
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22976184
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.22884060
71	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.22171615
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.21792838
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20801361
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19978856
75	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.19272282
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18904479
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14440208
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14440208
79	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13014770
80	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12561894
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12298302
82	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.12079982
83	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.12079982
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11302553
85	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10886477
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10291133
87	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10291133
88	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.08804560
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08219484
90	CDX2_22108803_ChIP-Seq_LS180_Human	1.06645056
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05885603
92	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.05382379
93	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.05262263
94	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04898247
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04150326
96	JUN_21703547_ChIP-Seq_K562_Human	1.03892453
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.02724980
98	TP53_16413492_ChIP-PET_HCT116_Human	1.02423431
99	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01164689
100	TBL1_22424771_ChIP-Seq_293T_Human	1.00467322

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.70636602
2	MP0008877_abnormal_DNA_methylation	3.07348420
3	MP0000569_abnormal_digit_pigmentation	2.87235872
4	MP0006292_abnormal_olfactory_placode	2.79062848
5	MP0003787_abnormal_imprinting	2.70277153
6	MP0003880_abnormal_central_pattern	2.69570380
7	MP0002102_abnormal_ear_morphology	2.60789258
8	MP0003890_abnormal_embryonic-extraembry	2.32824585
9	MP0000372_irregular_coat_pigmentation	2.28067489
10	MP0003121_genomic_imprinting	2.26664993
11	MP0005248_abnormal_Harderian_gland	2.23515588
12	MP0000516_abnormal_urinary_system	2.23497129
13	MP0005367_renal/urinary_system_phenotyp	2.23497129
14	MP0003122_maternal_imprinting	2.05138606
15	MP0002234_abnormal_pharynx_morphology	2.03803304
16	MP0006072_abnormal_retinal_apoptosis	1.97258462
17	MP0006054_spinal_hemorrhage	1.96582064
18	MP0000778_abnormal_nervous_system	1.95465873
19	MP0008789_abnormal_olfactory_epithelium	1.94081501
20	MP0008058_abnormal_DNA_repair	1.82894980
21	MP0002233_abnormal_nose_morphology	1.82505049
22	MP0002938_white_spotting	1.81545198
23	MP0005394_taste/olfaction_phenotype	1.77771661
24	MP0005499_abnormal_olfactory_system	1.77771661
25	MP0003937_abnormal_limbs/digits/tail_de	1.74987710
26	MP0010094_abnormal_chromosome_stability	1.74412155
27	MP0003119_abnormal_digestive_system	1.70313969
28	MP0005253_abnormal_eye_physiology	1.67546502
29	MP0006276_abnormal_autonomic_nervous	1.65032191
30	MP0001293_anophthalmia	1.59161111
31	MP0003385_abnormal_body_wall	1.54224188
32	MP0003567_abnormal_fetal_cardiomyocyte	1.53706370
33	MP0009697_abnormal_copulation	1.49088918
34	MP0005187_abnormal_penis_morphology	1.42873186
35	MP0003755_abnormal_palate_morphology	1.42387986
36	MP0008995_early_reproductive_senescence	1.40111183
37	MP0001984_abnormal_olfaction	1.38899689
38	MP0004215_abnormal_myocardial_fiber	1.36809538
39	MP0002751_abnormal_autonomic_nervous	1.34352846
40	MP0005174_abnormal_tail_pigmentation	1.34046023
41	MP0001286_abnormal_eye_development	1.28863508
42	MP0001529_abnormal_vocalization	1.23212629
43	MP0000428_abnormal_craniofacial_morphol	1.19090775
44	MP0005551_abnormal_eye_electrophysiolog	1.17694267
45	MP0003935_abnormal_craniofacial_develop	1.14022455
46	MP0005391_vision/eye_phenotype	1.12624477
47	MP0004885_abnormal_endolymph	1.11790357
48	MP0003195_calcinosis	1.07630868
49	MP0000631_abnormal_neuroendocrine_gland	1.05083893
50	MP0002837_dystrophic_cardiac_calcinosis	1.04217679
51	MP0000427_abnormal_hair_cycle	1.01954662
52	MP0001324_abnormal_eye_pigmentation	1.01540668
53	MP0002177_abnormal_outer_ear	1.00834785
54	MP0005084_abnormal_gallbladder_morpholo	1.00580171
55	MP0000647_abnormal_sebaceous_gland	1.00459841
56	MP0002127_abnormal_cardiovascular_syste	0.97391144
57	MP0002084_abnormal_developmental_patter	0.96347357
58	MP0001929_abnormal_gametogenesis	0.93138173
59	MP0001299_abnormal_eye_distance/	0.92860924
60	MP0009703_decreased_birth_body	0.92489329
61	MP0010030_abnormal_orbit_morphology	0.91475290
62	MP0001485_abnormal_pinna_reflex	0.91392900
63	MP0003938_abnormal_ear_development	0.91195320
64	MP0001188_hyperpigmentation	0.90770480
65	MP0002009_preneoplasia	0.90118767
66	MP0009053_abnormal_anal_canal	0.89872298
67	MP0004142_abnormal_muscle_tone	0.89036708
68	MP0003861_abnormal_nervous_system	0.88940653
69	MP0002210_abnormal_sex_determination	0.88352207
70	MP0002111_abnormal_tail_morphology	0.87935954
71	MP0003786_premature_aging	0.87293322
72	MP0002184_abnormal_innervation	0.86927574
73	MP0001879_abnormal_lymphatic_vessel	0.86464104
74	MP0001119_abnormal_female_reproductive	0.85786298
75	MP0000613_abnormal_salivary_gland	0.85477285
76	MP0000653_abnormal_sex_gland	0.85331866
77	MP0000383_abnormal_hair_follicle	0.84733245
78	MP0005195_abnormal_posterior_eye	0.84318408
79	MP0010678_abnormal_skin_adnexa	0.83785397
80	MP0003077_abnormal_cell_cycle	0.82699197
81	MP0002163_abnormal_gland_morphology	0.81726970
82	MP0000049_abnormal_middle_ear	0.81598638
83	MP0004957_abnormal_blastocyst_morpholog	0.80427236
84	MP0000537_abnormal_urethra_morphology	0.80001155
85	MP0003137_abnormal_impulse_conducting	0.79533789
86	MP0004197_abnormal_fetal_growth/weight/	0.79320293
87	MP0001145_abnormal_male_reproductive	0.78939442
88	MP0004133_heterotaxia	0.78698521
89	MP0004924_abnormal_behavior	0.77837704
90	MP0005386_behavior/neurological_phenoty	0.77837704
91	MP0000432_abnormal_head_morphology	0.77330844
92	MP0004145_abnormal_muscle_electrophysio	0.77299173
93	MP0010352_gastrointestinal_tract_polyps	0.76486058
94	MP0002109_abnormal_limb_morphology	0.74989850
95	MP0003221_abnormal_cardiomyocyte_apopto	0.74509510
96	MP0004085_abnormal_heartbeat	0.74422219
97	MP0002736_abnormal_nociception_after	0.73822339
98	MP0001697_abnormal_embryo_size	0.73655058
99	MP0002090_abnormal_vision	0.73375835
100	MP0005171_absent_coat_pigmentation	0.73216913

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	4.86670352
2	Intestinal atresia (HP:0011100)	3.28245693
3	Papillary thyroid carcinoma (HP:0002895)	3.10177546
4	Hyperventilation (HP:0002883)	2.76246016
5	Thyroiditis (HP:0100646)	2.70631052
6	Abnormality of the metopic suture (HP:0005556)	2.68044668
7	Abnormality of the labia minora (HP:0012880)	2.67438449
8	Chronic hepatic failure (HP:0100626)	2.60896216
9	Neoplasm of the adrenal cortex (HP:0100641)	2.56735478
10	Aqueductal stenosis (HP:0002410)	2.51293891
11	True hermaphroditism (HP:0010459)	2.47620450
12	Long clavicles (HP:0000890)	2.44770087
13	Oligodactyly (hands) (HP:0001180)	2.38445973
14	Thyroid carcinoma (HP:0002890)	2.38109424
15	Prominent metopic ridge (HP:0005487)	2.36175716
16	Medial flaring of the eyebrow (HP:0010747)	2.35882339
17	Drooling (HP:0002307)	2.34092088
18	Colon cancer (HP:0003003)	2.33001007
19	Hypoplastic iliac wings (HP:0002866)	2.32381094
20	Methylmalonic acidemia (HP:0002912)	2.32066519
21	Ectopic kidney (HP:0000086)	2.31072272
22	Rhabdomyosarcoma (HP:0002859)	2.30683347
23	Tubulointerstitial nephritis (HP:0001970)	2.30327385
24	Pancreatic cysts (HP:0001737)	2.29715864
25	Hypothermia (HP:0002045)	2.25139031
26	Pancreatic islet-cell hyperplasia (HP:0004510)	2.19077676
27	Abnormality of midbrain morphology (HP:0002418)	2.16427626
28	Molar tooth sign on MRI (HP:0002419)	2.16427626
29	Abnormality of the astrocytes (HP:0100707)	2.15952333
30	Astrocytoma (HP:0009592)	2.15952333
31	Congenital primary aphakia (HP:0007707)	2.15606854
32	Genital tract atresia (HP:0001827)	2.15557817
33	Nephronophthisis (HP:0000090)	2.11573678
34	Hepatoblastoma (HP:0002884)	2.11546171
35	Excessive salivation (HP:0003781)	2.10237754
36	Abnormal lung lobation (HP:0002101)	2.09565729
37	Glioma (HP:0009733)	2.09253217
38	Pancreatic fibrosis (HP:0100732)	2.09080621
39	Gait imbalance (HP:0002141)	2.08507769
40	Vaginal atresia (HP:0000148)	2.08215661
41	Renal hypoplasia (HP:0000089)	2.06289360
42	Narrow forehead (HP:0000341)	2.04310425
43	Hypoplastic labia majora (HP:0000059)	2.04091748
44	Medulloblastoma (HP:0002885)	2.04013768
45	Nephrogenic diabetes insipidus (HP:0009806)	2.03783961
46	Abnormality of the ischium (HP:0003174)	2.03776075
47	Hip dysplasia (HP:0001385)	2.03603487
48	Abnormality of chromosome stability (HP:0003220)	1.99575658
49	Abnormality of the renal medulla (HP:0100957)	1.98907454
50	Hypoplastic pelvis (HP:0008839)	1.97693325
51	Abnormal hair whorl (HP:0010721)	1.96222305
52	Labial hypoplasia (HP:0000066)	1.94382667
53	Gonadotropin excess (HP:0000837)	1.94107426
54	Absent speech (HP:0001344)	1.91838373
55	Abnormality of the renal cortex (HP:0011035)	1.91114080
56	Abnormal pancreas size (HP:0012094)	1.90909079
57	Micropenis (HP:0000054)	1.89713946
58	Optic nerve hypoplasia (HP:0000609)	1.89392703
59	Truncal obesity (HP:0001956)	1.89171865
60	Cystic hygroma (HP:0000476)	1.87891449
61	Ependymoma (HP:0002888)	1.87439806
62	Thin upper lip vermilion (HP:0000219)	1.87133425
63	Embryonal renal neoplasm (HP:0011794)	1.86396372
64	Gastrointestinal atresia (HP:0002589)	1.86265074
65	Curly hair (HP:0002212)	1.84842280
66	Abnormality of vitamin B metabolism (HP:0004340)	1.83495870
67	Cupped ear (HP:0000378)	1.83293633
68	Nephroblastoma (Wilms tumor) (HP:0002667)	1.82409688
69	Abnormality of the labia majora (HP:0012881)	1.82311494
70	Poor coordination (HP:0002370)	1.81880980
71	Hypoplastic ischia (HP:0003175)	1.81352593
72	Bifid tongue (HP:0010297)	1.80232612
73	Postaxial hand polydactyly (HP:0001162)	1.79933378
74	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.78561831
75	Small hand (HP:0200055)	1.77634128
76	Hyperinsulinemic hypoglycemia (HP:0000825)	1.73485820
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.73224456
78	Renal cortical cysts (HP:0000803)	1.72318775
79	Disproportionate short-trunk short stature (HP:0003521)	1.70244661
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69744118
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.68888798
82	Hypoplastic female external genitalia (HP:0012815)	1.68830651
83	Gastroesophageal reflux (HP:0002020)	1.67631028
84	Sloping forehead (HP:0000340)	1.67481818
85	Neoplasm of the oral cavity (HP:0100649)	1.66454723
86	Abnormality of the duodenum (HP:0002246)	1.64813152
87	Choroideremia (HP:0001139)	1.64664587
88	Downturned corners of mouth (HP:0002714)	1.64375300
89	Biliary tract neoplasm (HP:0100574)	1.63807294
90	Hypoglycemic seizures (HP:0002173)	1.63341461
91	Chorioretinal atrophy (HP:0000533)	1.62139040
92	Abnormal biliary tract morphology (HP:0012440)	1.61508682
93	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.61337387
94	Hypoplasia of the fovea (HP:0007750)	1.61337387
95	Neoplasm of striated muscle (HP:0009728)	1.61184803
96	Postaxial foot polydactyly (HP:0001830)	1.58820724
97	Scrotal hypoplasia (HP:0000046)	1.57973303
98	Tented upper lip vermilion (HP:0010804)	1.57922560
99	Astigmatism (HP:0000483)	1.57816590
100	Broad-based gait (HP:0002136)	1.57475487

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.86891774
2	TRIM28	3.24543607
3	WNK3	3.10115972
4	ERBB3	2.76292059
5	CASK	2.68403679
6	PNCK	2.53840990
7	MKNK2	2.38371213
8	ACVR1B	2.32656408
9	TNIK	2.29724170
10	MARK1	2.25356368
11	MAP3K4	2.12400627
12	BMPR1B	2.05464942
13	WEE1	1.91693571
14	NUAK1	1.89937233
15	EPHA4	1.89163550
16	EIF2AK3	1.81011982
17	MST4	1.80766823
18	AKT3	1.79051809
19	BRSK2	1.78548671
20	BCR	1.76737940
21	MAPK13	1.69447698
22	PLK2	1.63940714
23	PLK4	1.63244318
24	MKNK1	1.59400251
25	TAF1	1.53866402
26	MAP3K9	1.50085902
27	NLK	1.41220009
28	MAP4K2	1.35829038
29	PLK3	1.32602446
30	FGFR2	1.30400526
31	STK39	1.24610949
32	PAK3	1.24481644
33	INSRR	1.24035424
34	CCNB1	1.18075237
35	FER	1.16384324
36	BRD4	1.14464402
37	STK3	1.06847648
38	GRK1	1.04854749
39	CSNK1G1	1.04659043
40	MAP2K7	1.01958884
41	TSSK6	1.00799309
42	TGFBR1	0.98643174
43	ZAK	0.94958546
44	SIK3	0.91250929
45	SRPK1	0.89079562
46	YES1	0.87821195
47	CSNK1G2	0.85921199
48	NEK1	0.84647267
49	KSR1	0.84485474
50	EPHA3	0.82380283
51	SGK2	0.81930536
52	PINK1	0.77455336
53	BUB1	0.72402258
54	CSNK1A1L	0.72366098
55	OBSCN	0.72328773
56	PIK3CG	0.71127652
57	PRKCE	0.70645480
58	STK38L	0.70172381
59	CAMK1G	0.68643007
60	PRKD3	0.67682372
61	FGFR1	0.67188357
62	CSNK1G3	0.66835911
63	PASK	0.65950837
64	PLK1	0.61422048
65	ATM	0.60526166
66	EIF2AK1	0.59367337
67	TTK	0.56561209
68	LATS1	0.53836716
69	PRKCG	0.53377829
70	BMPR2	0.52601060
71	ROCK1	0.51854457
72	MAP3K2	0.51344233
73	PKN1	0.50447298
74	EPHB2	0.50377940
75	FLT3	0.49248214
76	DYRK2	0.48017709
77	NEK9	0.47515376
78	MINK1	0.46307057
79	NTRK3	0.44185132
80	TGFBR2	0.43045907
81	EIF2AK2	0.42138043
82	PBK	0.41761486
83	STK10	0.40221177
84	OXSR1	0.40115460
85	TEC	0.38616629
86	CHEK2	0.35498266
87	BRSK1	0.34103911
88	MAP2K4	0.32075344
89	ERBB4	0.31971991
90	FGFR3	0.31807533
91	TIE1	0.30830695
92	VRK1	0.30163099
93	CHEK1	0.27471978
94	PRKAA1	0.26816920
95	EGFR	0.26611113
96	SGK3	0.26476989
97	CSNK1D	0.26427919
98	ATR	0.26354041
99	SGK223	0.25664754
100	SGK494	0.25664754

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.41961646
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.40503579
3	Propanoate metabolism_Homo sapiens_hsa00640	2.98375692
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.83903270
5	Basal transcription factors_Homo sapiens_hsa03022	2.77687249
6	Protein export_Homo sapiens_hsa03060	2.47411358
7	Butanoate metabolism_Homo sapiens_hsa00650	2.33170672
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.21710544
9	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.04040516
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.95478027
11	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.85097148
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.82802200
13	RNA degradation_Homo sapiens_hsa03018	1.80824146
14	RNA transport_Homo sapiens_hsa03013	1.72345503
15	Cell cycle_Homo sapiens_hsa04110	1.68180513
16	Homologous recombination_Homo sapiens_hsa03440	1.68006467
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.66737768
18	Oocyte meiosis_Homo sapiens_hsa04114	1.65604406
19	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.62467329
20	Basal cell carcinoma_Homo sapiens_hsa05217	1.58573524
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.56940230
22	Regulation of autophagy_Homo sapiens_hsa04140	1.49563619
23	Wnt signaling pathway_Homo sapiens_hsa04310	1.47465307
24	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.42931996
25	Hippo signaling pathway_Homo sapiens_hsa04390	1.41262992
26	Phototransduction_Homo sapiens_hsa04744	1.38963817
27	Circadian rhythm_Homo sapiens_hsa04710	1.30269085
28	p53 signaling pathway_Homo sapiens_hsa04115	1.29117548
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25282674
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.21494174
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.17305022
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.16573375
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.14770759
34	Nicotine addiction_Homo sapiens_hsa05033	1.13924313
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.12774333
36	Olfactory transduction_Homo sapiens_hsa04740	1.12602145
37	Adherens junction_Homo sapiens_hsa04520	1.09924938
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.08566871
39	Mismatch repair_Homo sapiens_hsa03430	1.05162708
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03181610
41	Selenocompound metabolism_Homo sapiens_hsa00450	0.94925528
42	Taste transduction_Homo sapiens_hsa04742	0.93439559
43	Lysine degradation_Homo sapiens_hsa00310	0.90491592
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88495125
45	Tight junction_Homo sapiens_hsa04530	0.88105932
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83654974
47	Axon guidance_Homo sapiens_hsa04360	0.82889750
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.81933250
49	FoxO signaling pathway_Homo sapiens_hsa04068	0.79454225
50	MicroRNAs in cancer_Homo sapiens_hsa05206	0.76629740
51	Melanogenesis_Homo sapiens_hsa04916	0.75073583
52	Fatty acid elongation_Homo sapiens_hsa00062	0.74925782
53	Dopaminergic synapse_Homo sapiens_hsa04728	0.72637591
54	Colorectal cancer_Homo sapiens_hsa05210	0.72560164
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66108080
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64871851
57	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.62949828
58	Circadian entrainment_Homo sapiens_hsa04713	0.62128525
59	Long-term depression_Homo sapiens_hsa04730	0.56932166
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.55092632
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54332931
62	Prostate cancer_Homo sapiens_hsa05215	0.53577616
63	Melanoma_Homo sapiens_hsa05218	0.51898745
64	Peroxisome_Homo sapiens_hsa04146	0.50468893
65	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49166929
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.49105569
67	Alcoholism_Homo sapiens_hsa05034	0.46882894
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45450327
69	Serotonergic synapse_Homo sapiens_hsa04726	0.45118918
70	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.44599800
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43454811
72	Caffeine metabolism_Homo sapiens_hsa00232	0.43382595
73	Insulin secretion_Homo sapiens_hsa04911	0.43128861
74	GABAergic synapse_Homo sapiens_hsa04727	0.42428976
75	Renin secretion_Homo sapiens_hsa04924	0.42297665
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.41933270
77	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40931553
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.40029356
79	Amphetamine addiction_Homo sapiens_hsa05031	0.40021906
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.39581441
81	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.38258622
82	Rap1 signaling pathway_Homo sapiens_hsa04015	0.36042088
83	Spliceosome_Homo sapiens_hsa03040	0.35911174
84	Morphine addiction_Homo sapiens_hsa05032	0.35323269
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.34449363
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34160472
87	Type II diabetes mellitus_Homo sapiens_hsa04930	0.33296765
88	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.32006710
89	RNA polymerase_Homo sapiens_hsa03020	0.31511434
90	Endometrial cancer_Homo sapiens_hsa05213	0.31389078
91	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.29886547
92	Prolactin signaling pathway_Homo sapiens_hsa04917	0.28908671
93	Ras signaling pathway_Homo sapiens_hsa04014	0.27951156
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27873987
95	Gap junction_Homo sapiens_hsa04540	0.27830664
96	Linoleic acid metabolism_Homo sapiens_hsa00591	0.27464104
97	Long-term potentiation_Homo sapiens_hsa04720	0.26747221
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.26720876
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.26536044
100	One carbon pool by folate_Homo sapiens_hsa00670	0.26292982

ZNF518B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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