ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.95263504
2	neural tube formation (GO:0001841)	4.53052989
3	behavioral response to ethanol (GO:0048149)	3.89799563
4	DNA double-strand break processing (GO:0000729)	3.89107546
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.72323510
6	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.71609335
7	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.71609335
8	regulation of translation, ncRNA-mediated (GO:0045974)	3.71609335
9	regulation of hippo signaling (GO:0035330)	3.69388130
10	tryptophan catabolic process (GO:0006569)	3.66490349
11	indole-containing compound catabolic process (GO:0042436)	3.66490349
12	indolalkylamine catabolic process (GO:0046218)	3.66490349
13	regulation of posttranscriptional gene silencing (GO:0060147)	3.63382637
14	regulation of gene silencing by miRNA (GO:0060964)	3.63382637
15	regulation of gene silencing by RNA (GO:0060966)	3.63382637
16	replication fork processing (GO:0031297)	3.62078686
17	kynurenine metabolic process (GO:0070189)	3.58269960
18	indolalkylamine metabolic process (GO:0006586)	3.50590713
19	protein localization to cilium (GO:0061512)	3.31222241
20	centriole replication (GO:0007099)	3.31089015
21	recombinational repair (GO:0000725)	3.28504364
22	double-strand break repair via homologous recombination (GO:0000724)	3.28159852
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.17857367
24	response to pheromone (GO:0019236)	3.13213764
25	tryptophan metabolic process (GO:0006568)	3.12710822
26	fucose catabolic process (GO:0019317)	3.11311781
27	L-fucose metabolic process (GO:0042354)	3.11311781
28	L-fucose catabolic process (GO:0042355)	3.11311781
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.08193458
30	monoubiquitinated protein deubiquitination (GO:0035520)	3.08139880
31	positive regulation of developmental pigmentation (GO:0048087)	3.06172365
32	protein K11-linked deubiquitination (GO:0035871)	3.02532808
33	reciprocal meiotic recombination (GO:0007131)	2.97022203
34	reciprocal DNA recombination (GO:0035825)	2.97022203
35	presynaptic membrane assembly (GO:0097105)	2.96936372
36	microtubule anchoring (GO:0034453)	2.92850257
37	detection of light stimulus involved in sensory perception (GO:0050962)	2.92656828
38	detection of light stimulus involved in visual perception (GO:0050908)	2.92656828
39	reflex (GO:0060004)	2.92262763
40	photoreceptor cell maintenance (GO:0045494)	2.89925853
41	limb bud formation (GO:0060174)	2.88309043
42	regulation of pigment cell differentiation (GO:0050932)	2.87646941
43	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.87620735
44	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.87528220
45	prenylation (GO:0097354)	2.85613688
46	protein prenylation (GO:0018342)	2.85613688
47	retinal cone cell development (GO:0046549)	2.83625525
48	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.82205556
49	meiotic chromosome segregation (GO:0045132)	2.80222897
50	nonmotile primary cilium assembly (GO:0035058)	2.78328038
51	microtubule polymerization or depolymerization (GO:0031109)	2.76815461
52	cilium morphogenesis (GO:0060271)	2.75829321
53	kidney morphogenesis (GO:0060993)	2.75706381
54	regulation of sarcomere organization (GO:0060297)	2.75418248
55	somite development (GO:0061053)	2.74930928
56	signal peptide processing (GO:0006465)	2.74316453
57	pyrimidine nucleobase catabolic process (GO:0006208)	2.72514569
58	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.72244188
59	microtubule depolymerization (GO:0007019)	2.70076944
60	cilium organization (GO:0044782)	2.67922594
61	indole-containing compound metabolic process (GO:0042430)	2.66357551
62	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.65828217
63	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.65828217
64	cilium assembly (GO:0042384)	2.64009471
65	transmission of nerve impulse (GO:0019226)	2.63543263
66	inner ear receptor stereocilium organization (GO:0060122)	2.61471827
67	microtubule organizing center organization (GO:0031023)	2.59884997
68	presynaptic membrane organization (GO:0097090)	2.59558299
69	postsynaptic membrane organization (GO:0001941)	2.59151738
70	epithelial cilium movement (GO:0003351)	2.57294808
71	intraciliary transport (GO:0042073)	2.57263692
72	gamma-aminobutyric acid transport (GO:0015812)	2.56550580
73	sympathetic nervous system development (GO:0048485)	2.55233063
74	regulation of centrosome duplication (GO:0010824)	2.54566972
75	oxidative demethylation (GO:0070989)	2.54482000
76	tachykinin receptor signaling pathway (GO:0007217)	2.54233792
77	limb development (GO:0060173)	2.51605004
78	appendage development (GO:0048736)	2.51605004
79	regulation of centriole replication (GO:0046599)	2.51382867
80	regulation of DNA endoreduplication (GO:0032875)	2.51318147
81	centrosome organization (GO:0051297)	2.51067981
82	interkinetic nuclear migration (GO:0022027)	2.50196945
83	sulfation (GO:0051923)	2.49630722
84	histone H3-K9 methylation (GO:0051567)	2.48909190
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.48044086
86	protein K48-linked deubiquitination (GO:0071108)	2.47835021
87	neuronal action potential (GO:0019228)	2.46803027
88	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.46289617
89	olfactory bulb development (GO:0021772)	2.43643550
90	cilium movement (GO:0003341)	2.43464910
91	regulation of telomere maintenance (GO:0032204)	2.43176075
92	resolution of meiotic recombination intermediates (GO:0000712)	2.40993169
93	cellular response to sterol (GO:0036315)	2.40514714
94	spinal cord motor neuron differentiation (GO:0021522)	2.40166879
95	central nervous system neuron axonogenesis (GO:0021955)	2.40159346
96	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.38834671
97	regulation of mitotic spindle checkpoint (GO:1903504)	2.38834671
98	cornea development in camera-type eye (GO:0061303)	2.37954221
99	regulation of meiosis I (GO:0060631)	2.37797876
100	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.37411905

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.37350742
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.37215199
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.22668148
4	VDR_22108803_ChIP-Seq_LS180_Human	2.87587446
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.86501117
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.78321016
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.73043357
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.67147868
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64246197
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55871433
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.46567484
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.45786294
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.45314267
14	FUS_26573619_Chip-Seq_HEK293_Human	2.41581309
15	EWS_26573619_Chip-Seq_HEK293_Human	2.40244516
16	P300_19829295_ChIP-Seq_ESCs_Human	2.19720385
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11628138
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08730905
19	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08210074
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.06920878
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.97361853
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.95411804
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.87360808
24	STAT3_23295773_ChIP-Seq_U87_Human	1.85970365
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.82170978
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75967316
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.73757246
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69057917
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67675538
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.65768371
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65768371
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62007118
33	TCF4_23295773_ChIP-Seq_U87_Human	1.61487148
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60715522
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.59064090
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.55600228
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.54660657
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.53130750
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53130750
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.52973342
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50888971
42	AR_25329375_ChIP-Seq_VCAP_Human	1.49239329
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.46354461
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46309571
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45342579
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45296487
47	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.42501403
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42119865
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37208497
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36752700
51	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36523300
52	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.32975851
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32542278
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.31439658
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30995504
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30398371
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27446835
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26719104
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26491921
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26367285
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24842346
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23771342
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22998726
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.19111516
65	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.19032819
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.18935614
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18822432
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18821500
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17978360
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17389322
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16655263
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16655263
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16491566
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16313036
75	TP53_16413492_ChIP-PET_HCT116_Human	1.13602319
76	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13325552
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12478498
78	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10520217
79	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.09175306
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08875454
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06753333
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06314680
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.04769387
84	E2F7_22180533_ChIP-Seq_HELA_Human	1.04450512
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.04205524
86	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03424824
87	KDM2B_26808549_Chip-Seq_REH_Human	1.03291210
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02653600
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02438025
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02218207
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01472926
92	ELK1_19687146_ChIP-ChIP_HELA_Human	0.99856704
93	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98491287
94	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95333034
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95131331
96	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.94828385
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94337999
98	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93808460
99	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.93643137
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.93394367

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.47831912
2	MP0000569_abnormal_digit_pigmentation	3.04026590
3	MP0003880_abnormal_central_pattern	2.64530771
4	MP0004043_abnormal_pH_regulation	2.49142242
5	MP0006292_abnormal_olfactory_placode	2.48442910
6	MP0008877_abnormal_DNA_methylation	2.45116095
7	MP0009046_muscle_twitch	2.21626811
8	MP0005551_abnormal_eye_electrophysiolog	2.17120358
9	MP0002102_abnormal_ear_morphology	2.10028501
10	MP0001968_abnormal_touch/_nociception	2.00480843
11	MP0003195_calcinosis	1.97732732
12	MP0003646_muscle_fatigue	1.92858405
13	MP0003787_abnormal_imprinting	1.91698996
14	MP0009745_abnormal_behavioral_response	1.89840168
15	MP0000631_abnormal_neuroendocrine_gland	1.89360527
16	MP0003136_yellow_coat_color	1.86688121
17	MP0006072_abnormal_retinal_apoptosis	1.82540541
18	MP0010094_abnormal_chromosome_stability	1.81019193
19	MP0005646_abnormal_pituitary_gland	1.80602797
20	MP0002736_abnormal_nociception_after	1.78634008
21	MP0008058_abnormal_DNA_repair	1.78336237
22	MP0003890_abnormal_embryonic-extraembry	1.75301417
23	MP0005253_abnormal_eye_physiology	1.72975164
24	MP0009697_abnormal_copulation	1.68721907
25	MP0001501_abnormal_sleep_pattern	1.66905902
26	MP0001485_abnormal_pinna_reflex	1.66711947
27	MP0001486_abnormal_startle_reflex	1.65073005
28	MP0002735_abnormal_chemical_nociception	1.60024945
29	MP0006276_abnormal_autonomic_nervous	1.59756687
30	MP0001984_abnormal_olfaction	1.57998626
31	MP0002938_white_spotting	1.57833766
32	MP0000778_abnormal_nervous_system	1.55763355
33	MP0000427_abnormal_hair_cycle	1.54669884
34	MP0002638_abnormal_pupillary_reflex	1.50507915
35	MP0002064_seizures	1.45349387
36	MP0002272_abnormal_nervous_system	1.44357363
37	MP0001529_abnormal_vocalization	1.43733826
38	MP0005645_abnormal_hypothalamus_physiol	1.42608936
39	MP0003635_abnormal_synaptic_transmissio	1.41425922
40	MP0002653_abnormal_ependyma_morphology	1.40352575
41	MP0004147_increased_porphyrin_level	1.38115327
42	MP0002572_abnormal_emotion/affect_behav	1.37690300
43	MP0004133_heterotaxia	1.35475602
44	MP0004145_abnormal_muscle_electrophysio	1.35055536
45	MP0003121_genomic_imprinting	1.33214583
46	MP0004142_abnormal_muscle_tone	1.31772352
47	MP0003718_maternal_effect	1.28396919
48	MP0008872_abnormal_physiological_respon	1.26940476
49	MP0002751_abnormal_autonomic_nervous	1.24960227
50	MP0004924_abnormal_behavior	1.23698356
51	MP0005386_behavior/neurological_phenoty	1.23698356
52	MP0003937_abnormal_limbs/digits/tail_de	1.23238867
53	MP0005174_abnormal_tail_pigmentation	1.22980222
54	MP0002557_abnormal_social/conspecific_i	1.22510786
55	MP0002067_abnormal_sensory_capabilities	1.22296907
56	MP0002063_abnormal_learning/memory/cond	1.19836793
57	MP0003119_abnormal_digestive_system	1.18806768
58	MP0000383_abnormal_hair_follicle	1.16865085
59	MP0001293_anophthalmia	1.14930591
60	MP0002234_abnormal_pharynx_morphology	1.14086926
61	MP0001188_hyperpigmentation	1.09844846
62	MP0004885_abnormal_endolymph	1.09706654
63	MP0005423_abnormal_somatic_nervous	1.09063484
64	MP0004742_abnormal_vestibular_system	1.07646552
65	MP0008789_abnormal_olfactory_epithelium	1.07256469
66	MP0002184_abnormal_innervation	1.04659116
67	MP0002734_abnormal_mechanical_nocicepti	1.02956131
68	MP0002822_catalepsy	1.02867800
69	MP0003698_abnormal_male_reproductive	1.00707209
70	MP0002752_abnormal_somatic_nervous	1.00615230
71	MP0005195_abnormal_posterior_eye	0.98988079
72	MP0000372_irregular_coat_pigmentation	0.98852572
73	MP0001970_abnormal_pain_threshold	0.98691932
74	MP0002928_abnormal_bile_duct	0.98482867
75	MP0002837_dystrophic_cardiac_calcinosis	0.96653950
76	MP0002733_abnormal_thermal_nociception	0.96462836
77	MP0005499_abnormal_olfactory_system	0.95108570
78	MP0005394_taste/olfaction_phenotype	0.95108570
79	MP0001986_abnormal_taste_sensitivity	0.92979225
80	MP0004859_abnormal_synaptic_plasticity	0.92332099
81	MP0002095_abnormal_skin_pigmentation	0.91274396
82	MP0002882_abnormal_neuron_morphology	0.90397464
83	MP0005391_vision/eye_phenotype	0.87403114
84	MP0001929_abnormal_gametogenesis	0.87154087
85	MP0004270_analgesia	0.86584302
86	MP0004215_abnormal_myocardial_fiber	0.86233046
87	MP0008961_abnormal_basal_metabolism	0.85540796
88	MP0000955_abnormal_spinal_cord	0.85236529
89	MP0001963_abnormal_hearing_physiology	0.85008123
90	MP0002152_abnormal_brain_morphology	0.81366207
91	MP0005187_abnormal_penis_morphology	0.81193227
92	MP0002210_abnormal_sex_determination	0.81128091
93	MP0003861_abnormal_nervous_system	0.81001472
94	MP0000647_abnormal_sebaceous_gland	0.80686341
95	MP0000026_abnormal_inner_ear	0.78660985
96	MP0008995_early_reproductive_senescence	0.77925909
97	MP0000049_abnormal_middle_ear	0.74377038
98	MP0001177_atelectasis	0.74019921
99	MP0001286_abnormal_eye_development	0.73864238
100	MP0000653_abnormal_sex_gland	0.73746755

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.23863450
2	Pancreatic cysts (HP:0001737)	4.13525756
3	Pancreatic fibrosis (HP:0100732)	3.79939645
4	True hermaphroditism (HP:0010459)	3.57755076
5	Nephronophthisis (HP:0000090)	3.44285484
6	Abnormality of midbrain morphology (HP:0002418)	3.40978424
7	Molar tooth sign on MRI (HP:0002419)	3.40978424
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.13435511
9	Abnormality of the renal medulla (HP:0100957)	3.12388630
10	Gaze-evoked nystagmus (HP:0000640)	3.08665429
11	Genetic anticipation (HP:0003743)	3.01710485
12	Congenital stationary night blindness (HP:0007642)	3.01038643
13	Chromsome breakage (HP:0040012)	2.96033077
14	Chronic hepatic failure (HP:0100626)	2.95930380
15	Medial flaring of the eyebrow (HP:0010747)	2.95616936
16	Progressive cerebellar ataxia (HP:0002073)	2.93025466
17	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.84583532
18	Broad-based gait (HP:0002136)	2.82450233
19	Cystic liver disease (HP:0006706)	2.79563877
20	Protruding tongue (HP:0010808)	2.78878826
21	Abnormality of the renal cortex (HP:0011035)	2.78496920
22	Febrile seizures (HP:0002373)	2.65755237
23	Gait imbalance (HP:0002141)	2.62652676
24	Attenuation of retinal blood vessels (HP:0007843)	2.59782107
25	Congenital primary aphakia (HP:0007707)	2.56047626
26	Colon cancer (HP:0003003)	2.51583669
27	Patellar aplasia (HP:0006443)	2.47419604
28	Clumsiness (HP:0002312)	2.42938970
29	Meckel diverticulum (HP:0002245)	2.41681513
30	Abnormality of the ileum (HP:0001549)	2.40518189
31	Abnormality of chromosome stability (HP:0003220)	2.38992393
32	Birth length less than 3rd percentile (HP:0003561)	2.36853663
33	Genital tract atresia (HP:0001827)	2.35300998
34	Absent speech (HP:0001344)	2.31792207
35	Inability to walk (HP:0002540)	2.31297578
36	Vaginal atresia (HP:0000148)	2.30646390
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.28655336
38	Abnormality of alanine metabolism (HP:0010916)	2.28655336
39	Hyperalaninemia (HP:0003348)	2.28655336
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.28274309
41	Type II lissencephaly (HP:0007260)	2.27899184
42	Nephrogenic diabetes insipidus (HP:0009806)	2.27788533
43	Aplasia/Hypoplasia of the patella (HP:0006498)	2.26210097
44	Abolished electroretinogram (ERG) (HP:0000550)	2.26187778
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.24413453
46	Oligodactyly (hands) (HP:0001180)	2.21335007
47	Abnormality of the labia minora (HP:0012880)	2.20683564
48	Clubbing of toes (HP:0100760)	2.19895315
49	Lissencephaly (HP:0001339)	2.19466967
50	Ectopic kidney (HP:0000086)	2.17735745
51	Pendular nystagmus (HP:0012043)	2.16680298
52	Progressive inability to walk (HP:0002505)	2.16513044
53	Postaxial foot polydactyly (HP:0001830)	2.15781475
54	Anencephaly (HP:0002323)	2.13770725
55	Abnormal biliary tract physiology (HP:0012439)	2.13235713
56	Bile duct proliferation (HP:0001408)	2.13235713
57	Sloping forehead (HP:0000340)	2.12515375
58	Cerebellar dysplasia (HP:0007033)	2.11624931
59	Fair hair (HP:0002286)	2.11353865
60	Intestinal atresia (HP:0011100)	2.11148933
61	Sclerocornea (HP:0000647)	2.10630384
62	Poor coordination (HP:0002370)	2.10328844
63	Astigmatism (HP:0000483)	2.08240463
64	Drooling (HP:0002307)	2.05087911
65	Tubular atrophy (HP:0000092)	2.02735319
66	Widely spaced teeth (HP:0000687)	2.00853751
67	Focal motor seizures (HP:0011153)	1.98701635
68	Focal seizures (HP:0007359)	1.97870878
69	Bony spicule pigmentary retinopathy (HP:0007737)	1.92168260
70	Volvulus (HP:0002580)	1.91990845
71	Dialeptic seizures (HP:0011146)	1.91984297
72	Small hand (HP:0200055)	1.91525556
73	Preaxial hand polydactyly (HP:0001177)	1.90288725
74	Congenital hepatic fibrosis (HP:0002612)	1.89842427
75	Dandy-Walker malformation (HP:0001305)	1.89597553
76	Optic nerve hypoplasia (HP:0000609)	1.89285584
77	Abnormality of the preputium (HP:0100587)	1.88618384
78	Abnormality of the renal collecting system (HP:0004742)	1.87866486
79	Cupped ear (HP:0000378)	1.86933695
80	Stomach cancer (HP:0012126)	1.86363760
81	Abnormal drinking behavior (HP:0030082)	1.85231184
82	Polydipsia (HP:0001959)	1.85231184
83	Duplicated collecting system (HP:0000081)	1.83911330
84	Postaxial hand polydactyly (HP:0001162)	1.82022245
85	Renal cortical cysts (HP:0000803)	1.81976628
86	Absent/shortened dynein arms (HP:0200106)	1.81267465
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81267465
88	Excessive salivation (HP:0003781)	1.80400902
89	Small intestinal stenosis (HP:0012848)	1.79758008
90	Duodenal stenosis (HP:0100867)	1.79758008
91	Chorioretinal atrophy (HP:0000533)	1.78393906
92	Abnormality of the carotid arteries (HP:0005344)	1.77894728
93	Abnormality of the pons (HP:0007361)	1.77596285
94	Short foot (HP:0001773)	1.76315122
95	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76267619
96	Highly arched eyebrow (HP:0002553)	1.75878321
97	Preaxial foot polydactyly (HP:0001841)	1.75625594
98	Increased corneal curvature (HP:0100692)	1.74678576
99	Keratoconus (HP:0000563)	1.74678576
100	Furrowed tongue (HP:0000221)	1.72756619

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.48200764
2	BMPR1B	3.05778494
3	ACVR1B	2.91140063
4	NUAK1	2.87676779
5	LATS1	2.82565131
6	MAP4K2	2.34839082
7	ZAK	2.32288403
8	MKNK2	2.17963480
9	WNK3	2.13458269
10	ADRBK2	2.10071341
11	MAP3K4	2.01983449
12	CASK	1.99769121
13	CDC7	1.96502422
14	MAPK13	1.76926892
15	BRSK2	1.75406061
16	TNIK	1.70180104
17	GRK1	1.55771578
18	AKT3	1.45244006
19	STK38L	1.44732176
20	MKNK1	1.44668602
21	TLK1	1.39806912
22	PLK4	1.35945253
23	INSRR	1.35530913
24	OXSR1	1.28164153
25	EPHA4	1.26630597
26	TAOK3	1.26000871
27	NTRK3	1.21545731
28	WEE1	1.20449015
29	MARK1	1.13733284
30	DAPK2	1.12904308
31	PINK1	1.11314143
32	CAMKK2	1.11145565
33	STK39	1.09865230
34	CAMK1D	1.08269334
35	MAP2K7	1.05347337
36	PLK2	1.05009931
37	TGFBR1	1.03602584
38	STK3	1.03175106
39	IRAK1	0.96276092
40	FGFR2	0.95232417
41	CAMK1G	0.93654067
42	WNK4	0.93297852
43	TRIM28	0.92815250
44	BRD4	0.89650654
45	VRK1	0.89198531
46	PAK3	0.86680767
47	PNCK	0.86379139
48	ADRBK1	0.83365696
49	CCNB1	0.82925919
50	SIK2	0.79079903
51	NTRK2	0.78575594
52	ATR	0.78383673
53	BCR	0.77102369
54	PLK3	0.76178045
55	NLK	0.76004855
56	PRKCG	0.75093099
57	SGK2	0.72743677
58	PIK3CA	0.72512321
59	ERBB3	0.70034409
60	DYRK2	0.69628457
61	PLK1	0.66564666
62	CAMK1	0.64406563
63	CHEK2	0.64370935
64	CDK3	0.63139819
65	PRKCE	0.62063342
66	NEK2	0.61816549
67	CSNK1A1L	0.60811940
68	CSNK1G2	0.59790690
69	TEC	0.59200814
70	CSNK1G1	0.58133762
71	IRAK2	0.58004681
72	ATM	0.55956401
73	CAMK4	0.55480260
74	EIF2AK3	0.54092629
75	TIE1	0.49660727
76	OBSCN	0.49208978
77	PKN1	0.48669538
78	STK11	0.47781739
79	MELK	0.47645300
80	TAF1	0.47635250
81	SGK223	0.47275808
82	SGK494	0.47275808
83	CAMK2A	0.46849339
84	SRPK1	0.45025374
85	CSNK1D	0.43376701
86	CSNK1G3	0.42949218
87	DYRK1A	0.38487385
88	PTK2B	0.37873606
89	PRKAA2	0.36326274
90	PRKAA1	0.36163548
91	BRSK1	0.35305071
92	MAP2K4	0.34069089
93	WNK1	0.33089267
94	DYRK3	0.32055439
95	MAP3K7	0.31901669
96	CDK1	0.31646851
97	MAP2K6	0.31540475
98	CSNK1A1	0.30577946
99	PIK3CG	0.30534766
100	ERBB2	0.30399308

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.14157961
2	Homologous recombination_Homo sapiens_hsa03440	3.08975728
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.92953777
4	Phototransduction_Homo sapiens_hsa04744	2.56909256
5	Butanoate metabolism_Homo sapiens_hsa00650	2.30928169
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.24504384
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.22129190
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.12520138
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.04148141
10	Basal transcription factors_Homo sapiens_hsa03022	1.98207544
11	Taste transduction_Homo sapiens_hsa04742	1.97558125
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87103037
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.83870026
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82899216
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81035796
16	Morphine addiction_Homo sapiens_hsa05032	1.73423659
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.73095230
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.68229601
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.56733152
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56090266
21	Propanoate metabolism_Homo sapiens_hsa00640	1.53285539
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.53236803
23	Mismatch repair_Homo sapiens_hsa03430	1.52609570
24	Olfactory transduction_Homo sapiens_hsa04740	1.47552723
25	GABAergic synapse_Homo sapiens_hsa04727	1.43252003
26	Circadian entrainment_Homo sapiens_hsa04713	1.41271534
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.39102680
28	RNA polymerase_Homo sapiens_hsa03020	1.36434411
29	ABC transporters_Homo sapiens_hsa02010	1.31978670
30	Lysine degradation_Homo sapiens_hsa00310	1.30627349
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.28151772
32	RNA degradation_Homo sapiens_hsa03018	1.22636690
33	One carbon pool by folate_Homo sapiens_hsa00670	1.16210135
34	Serotonergic synapse_Homo sapiens_hsa04726	1.13743822
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.11344980
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10851691
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10743502
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08873383
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07878950
40	Insulin secretion_Homo sapiens_hsa04911	1.07733592
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07282738
42	Calcium signaling pathway_Homo sapiens_hsa04020	1.05948697
43	Salivary secretion_Homo sapiens_hsa04970	1.04832473
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01049868
45	DNA replication_Homo sapiens_hsa03030	1.00462869
46	Cell cycle_Homo sapiens_hsa04110	1.00128205
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99096423
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.96182891
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.95706685
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93726134
51	Caffeine metabolism_Homo sapiens_hsa00232	0.90062058
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.88783523
53	Retinol metabolism_Homo sapiens_hsa00830	0.87853038
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87499932
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86463367
56	Long-term depression_Homo sapiens_hsa04730	0.83204394
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.82681669
58	Regulation of autophagy_Homo sapiens_hsa04140	0.82237978
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81147933
60	Histidine metabolism_Homo sapiens_hsa00340	0.80374476
61	Cholinergic synapse_Homo sapiens_hsa04725	0.77650290
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.76880162
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.73096346
64	Purine metabolism_Homo sapiens_hsa00230	0.72803521
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72798167
66	Circadian rhythm_Homo sapiens_hsa04710	0.71244021
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70747832
68	RNA transport_Homo sapiens_hsa03013	0.69962826
69	Protein export_Homo sapiens_hsa03060	0.68867070
70	Base excision repair_Homo sapiens_hsa03410	0.68518088
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.66800067
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.64933738
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.62699567
74	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.62622298
75	Cocaine addiction_Homo sapiens_hsa05030	0.62266497
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.61554428
77	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60488248
78	Amphetamine addiction_Homo sapiens_hsa05031	0.59695632
79	Oocyte meiosis_Homo sapiens_hsa04114	0.59509149
80	Gastric acid secretion_Homo sapiens_hsa04971	0.59444373
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58755151
82	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.58450743
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.57463760
84	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.57320112
85	Peroxisome_Homo sapiens_hsa04146	0.55339472
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52252461
87	mRNA surveillance pathway_Homo sapiens_hsa03015	0.50943624
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50598042
89	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48695540
90	Renin secretion_Homo sapiens_hsa04924	0.48137503
91	Alcoholism_Homo sapiens_hsa05034	0.47181989
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45849314
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.44232822
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41442365
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40681902
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39905698
97	Huntingtons disease_Homo sapiens_hsa05016	0.39301114
98	p53 signaling pathway_Homo sapiens_hsa04115	0.37335336
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33807630
100	Wnt signaling pathway_Homo sapiens_hsa04310	0.31778546

ZNF519

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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